Shikha Tiwari

@sageuniversity.edu.in

Associate Professor, School of Sciences and CLAS Bhopal
Sanjeev Agrawal Global Educational University Bhopal

Shikha Tiwari


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https://researchid.co/shikhatiwari

RESEARCH, TEACHING, or OTHER INTERESTS

Multidisciplinary, Biotechnology, General Biochemistry, Genetics and Molecular Biology, Cancer Research
10

Scopus Publications

236

Scholar Citations

8

Scholar h-index

6

Scholar i10-index

Scopus Publications

  • Volatile biomarker signature of onion infected with Aspergillus niger and Aspergillus flavus under postharvest storage
    Shikha Tiwari, Jamna Prasad Gujar, Adinath Kate, Manoj Kumar Tripathi, Bharat Modhera, Debabandya Mohapatra
    Journal of Food Measurement and Characterization, 2026
  • miRNA genetic variations associated with the predisposition of oral squamous cell carcinoma in central Indian population
    Shikha Tiwari, Ritu Pandey, Vinay Kumar, Saikat Das, Vikas Gupta, Rajeev Nema, Ashok Kumar
    Non Coding RNA Research, 2024
    The disease burden of Oral Squamous Cell Carcinoma (OSCC) is rising day-by-day and is expected to rise 62 % through 2035. The chewing of tobacco, areca nut, and betel leaf, poor oral hygiene, and chronic infection are common risk factors of OSCC, but genetic and epigenetic factors also contribute equally. MicroRNAs (miRNAs) are comprised of small, non-coding endogenous RNA that regulate a plethora of biological activities by targeting messenger RNA through degradation or inhibition. Single Nucleotide Polymorphisms (SNPs) in miRNA genes can regulate the development and progression of OSCC. The present study aimed to determine the association between SNPs in miRNA genes (miRSNPs) with the risk of OSCC. A case-control study involving 225 histo-pathologically confirmed OSCC cases and 225 healthy controls was conducted, where 25 miRSNPs were analyzed by iPLEX MassArray analysis. A SNP rs12220909 in MIR4293 showed a highly protective effect (CC vs GG, OR = 0.0431, 95%CI = 0.005–0.323, p = 3e-6). Whereas three SNPs, namely, rs4705342 in MIR143 (CC vs TT, OR = 2.25, 95%CI = 2.00–2.53, p = 0.0008), rs531564 in MIR124 (CC vs GG, OR = 24.18, 95%CI = 3.22–181.37, p = 3e-6), and rs3746444 in MIR499 (AA vs GG, OR = 2.01, 95%CI = 1.32–3.05, p = 0.001) were significantly associated with a higher risk of OSCC. Additionally, NanoString-based nCounter miRNA expression profiling revealed that miR-499a (Log2FC = −1.07), and miR-143 (Log2FC = −1.56) were aberrantly expressed in OSCC tissue. Taken together, the above miSNPs may contribute to the high incidence of OSCC in central India. However, further studies with large cohorts and ethnic stratification are required to validate our findings.
  • METABOLIC ENGINEERING OF PLANT VOLATILES IN FRUITS AND VEGETABLES FOR POSTHARVEST QUALITY ENHANCEMENT
    Bioengineered Fruit and Vegetables Trends in Postharvest Quality Improvement, 2024
  • MicroRNA-based clinical trials for head and neck cancer
    Rajesh Kumar, Shikha Tiwari, Seetha Harilal
    Diagnostic Prognostic and Therapeutic Role of Micrornas in Head and Neck Cancer, 2024
  • Natural and genetically-modified animal models to investigate pulmonary and extrapulmonary manifestations of COVID-19
    Shikha Tiwari, Garima Goel, Ashok Kumar
    International Reviews of Immunology, 2024
    Coronavirus disease-19 (COVID-19), a pandemic caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), is a primarily respiratory tract disease. Suitable animal models for COVID-19 are required to study various aspects of pathogenesis, drug discovery, effective and safe vaccine development. Several laboratory animals including, non-human primates, hamsters, ferrets, transgenic mice, and zebrafish, have been used and proven their significance experimentally. Currently available animal models of SARS-CoV-2 can be broadly classified into two categories 1) natural animal models 2) genetically-modified that exhibit different degrees of susceptibility of SARS-CoV-2, tissue damage in respiratory and other organ systems. Not all the available animal models mimic COVID-19-like phenotype completely. Therefore, understanding various aspects of COVID-19 requires different animal models. In this review article, we provide an update on the immune response and clinical manifestations observed in naturally occurring and genetically-modified animals of COVID-19. We then review the transmission, viral replication, lung pathology, immunological aspects, and extrapulmonary phenotypes observed in various animal models. In the end, we put forth our perspective on the anticipated uses, disadvantages, and limitations of each type of animal model.
  • Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck Cancer
    Diagnostic Prognostic and Therapeutic Role of Micrornas in Head and Neck Cancer, 2024
  • MicroRNA expression profiling for disease progression assessment
    Shikha Tiwari, Ashok Kumar, Vinay Kumar, Payal Sharma
    Diagnostic Prognostic and Therapeutic Role of Micrornas in Head and Neck Cancer, 2024
  • Development of microRNA as prognostic markers in head and neck cancer
    Teeshyo Bhattacharya, Shikha Tiwari, Arijit Nandi, Wei-Yu Lin, Somasundaram Arumugam
    Diagnostic Prognostic and Therapeutic Role of Micrornas in Head and Neck Cancer, 2024
  • Association of Single Nucleotide Polymorphisms in KCNA10 and SLC13A3 Genes with the Susceptibility to Chronic Kidney Disease of Unknown Etiology in Central Indian Patients
    Ravita Kumari, Shikha Tiwari, Mahendra Atlani, Athira Anirudhan, Sudhir K. Goel, Ashok Kumar
    Biochemical Genetics, 2023
  • Association of single nucleotide polymorphism miRNA-146a (rs2910164) with increased predisposition to oral squamous cell carcinoma in central India population
    Shikha Tiwari, Ritu Pandey, Vinay Kumar, Saikat Das, Vikas Gupta, Supriya Vishwakarma, Rajeev Nema, Tulasi Sindhuja, Sana Hashmi, Ashok Kumar
    Cancer Biomarkers, 2023
    BACKGROUND: miRNAs play a crucial role in the genesis of cancer, either as tumor suppressor genes or as oncogenes. Single Nucleotide Polymorphisms (SNPs) in the seed region of microRNAs (miRNAs) can dysregulate their levels in the tissues and thereby affect carcinogenesis. The association of SNP in miR-146a (rs2910164) with the risk of oral squamous cell carcinoma (OSCC) has not been understood. OBJECTIVE: In the present study, we have determined the association and functional significance of miR-146a (rs2910164) SNP with susceptibility to OSCC predisposition. METHODS: In the present case-control study, we enrolled 430 subjects from central India (215 OSCC cases and 215 healthy controls). We performed genotyping by Kompetitive Allele Specific PCR (KASP), and their correlation with OSCC susceptibility was analyzed. miRNA expression profiling in tumor tissues and adjacent normal tissues from six OSCC patients was done by a NanoString n-Counter-based assay. Subsequently, gene ontology and pathway analysis were performed with FunRich version 3.13. RESULTS: The CC genotype of rs2910164 miR-146a was significantly associated with the increased risk for OSCC (CC vs GC, OR = 2.62; 95% CI: 1.48–4.66; p value = 0.001). However, the GC genotype was protective with GC vs CC (OR = 0.38, 95%CI =0.21–0.67, p-value = 0.001), and GC vs GG (OR = 0.58, 95%CI = 0.37–0.89, p-value = 0.01). CONCLUSION: Our finding suggests that SNP rs2910164 of miR-146a may be a genetic risk factor for OSCC susceptibility in the Central India population. However, more extensive multicenter studies are required to validate these findings.

RECENT SCHOLAR PUBLICATIONS

  • Volatile biomarker signature of onion infected with Aspergillus niger and Aspergillus flavus under postharvest storage
    S Tiwari, JP Gujar, A Kate, MK Tripathi, B Modhera, D Mohapatra
    Journal of Food Measurement and Characterization, 1-12 , 2026
    2026
  • microRNA Modulation: A Promising Combination Therapy for Cancer
    S Tiwari, D Bhatia, AK Yadav
    Springer Nature , 2026
    2026
    Citations: 1
  • Development of Resistance in Tumor for the Available Conventional Therapies
    P Sharma, J Sharma, B Nayak, S Tiwari, A Kumar
    microRNA Modulation: A Promising Combination Therapy for Cancer, 181-207 , 2026
    2026
  • Clinical Trials and Patent Updates of miRNA Therapy in Cancer
    R Mukherjee, A Tyagi, S Tiwari, A Arora
    microRNA Modulation: A Promising Combination Therapy for Cancer, 351-369 , 2026
    2026
    Citations: 1
  • Combination of miRNA and Photodynamic and Photothermal Anti-cancer Therapy
    P Sharma, S Tiwari
    microRNA Modulation: A Promising Combination Therapy for Cancer, 321-331 , 2026
    2026
  • Diagnosing resistant microbial community via nanohybrids: a brief crosstalk
    AK Yadav, D Verma, P Agarwal, S Tiwari, D Bhatia
    Nanodiagnostics to Identify and Detect Microbial Infections and … , 2026
    2026
  • miRNA genetic variations associated with the predisposition of oral squamous cell carcinoma in central Indian population
    S Tiwari, R Pandey, V Kumar, S Das, V Gupta, R Nema, A Kumar
    Non-Coding Rna Research 9 (4), 1333-1341 , 2024
    2024
    Citations: 5
  • Metabolic Engineering of Plant Volatiles in Fruits and Vegetables for Postharvest Quality Enhancement
    S Tiwari, P Bhatele
    Bioengineered Fruit and Vegetables, 307-328 , 2024
    2024
    Citations: 1
  • Glioblastoma Multiforme miRNA based Comprehensive Study to Validate Phytochemicals for Effective Treatment against Deadly Tumour through In Silico Evaluation
    RB Khan, S Tiwari, A Jarkharya, A Tiwari, R Chowdhary, A Shrivastava
    MicroRNA 13 (3), 240-250 , 2024
    2024
    Citations: 1
  • Diagnostic, prognostic, and therapeutic role of MicroRNAs in head and neck cancer
    A Kumar, N Arya, S Tiwari, R Khan
    Elsevier , 2024
    2024
    Citations: 4
  • MicroRNA expression profiling for disease progression assessment
    S Tiwari, A Kumar, V Kumar, P Sharma
    Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck … , 2024
    2024
  • MicroRNA-based clinical trials for head and neck cancer
    R Kumar, S Tiwari, S Harilal
    Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck … , 2024
    2024
    Citations: 4
  • Development of microRNA as prognostic markers in head and neck cancer
    T Bhattacharya, S Tiwari, A Nandi, WY Lin, S Arumugam
    Diagnostic, prognostic, and therapeutic role of microRNAs in head and neck … , 2024
    2024
    Citations: 4
  • Association of single nucleotide polymorphisms in KCNA10 and SLC13A3 genes with the susceptibility to chronic kidney disease of unknown etiology in central Indian patients
    R Kumari, S Tiwari, M Atlani, A Anirudhan, SK Goel, A Kumar
    Biochemical Genetics 61 (4), 1548-1566 , 2023
    2023
    Citations: 15
  • Spotting of Volatile Signatures through GC-MS Analysis of Bacterial and Fungal Infections in Stored Potatoes ( Solanum tuberosum L.)
    A Kate, S Tiwari, JP Gujar, B Modhera, MK Tripathi, H Ray, A Ghosh, ...
    Foods 12 (10), 2083 , 2023
    2023
    Citations: 11
  • Association of single nucleotide polymorphism miRNA-146a (rs2910164) with increased predisposition to oral squamous cell carcinoma in central India population
    S Tiwari, R Pandey, V Kumar, S Das, V Gupta, S Vishwakarma, R Nema, ...
    Cancer Biomarkers 38 (2), 203-214 , 2023
    2023
    Citations: 3
  • Electronic Nose for Fresh Produce Quality
    A Kate, S Tiwari, D Mohapatra
    Nondestructive Quality Assessment Techniques for Fresh Fruits and Vegetables … , 2022
    2022
    Citations: 1
  • Natural and genetically-modified animal models to investigate pulmonary and extrapulmonary manifestations of COVID-19
    GGAK Shikha Tiwari
    International Reviews of Immunology , 2022
    2022
    Citations: 11
  • Development of electronic nose for early spoilage detection of potato and onion during post-harvest storage
    A Ghosh, TK Ghosh, S Das, H Ray, D Mohapatra, B Modhera, D Ghosh, ...
    Materials NanoScience 9 (2), 101-114 , 2022
    2022
    Citations: 23
  • Biological relevance of VOCs emanating from red onions infected with Erwinia (Pectobacterium) carotovora under different storage conditions
    S Tiwari, U Goswami, A Kate, B Modhera, MK Tripathi, D Mohapatra
    Postharvest Biology and Technology 184, 111761 , 2022
    2022
    Citations: 9

MOST CITED SCHOLAR PUBLICATIONS

  • Volatile organic compounds (VOCs): Biomarkers for quality management of horticultural commodities during storage through e-sensing
    S Tiwari, A Kate, D Mohapatra, MK Tripathi, H Ray, A Akuli, A Ghosh, ...
    Trends in Food Science & Technology 106, 417-433 , 2020
    2020
    Citations: 110
  • Development of electronic nose for early spoilage detection of potato and onion during post-harvest storage
    A Ghosh, TK Ghosh, S Das, H Ray, D Mohapatra, B Modhera, D Ghosh, ...
    Materials NanoScience 9 (2), 101-114 , 2022
    2022
    Citations: 23
  • Association of single nucleotide polymorphisms in KCNA10 and SLC13A3 genes with the susceptibility to chronic kidney disease of unknown etiology in central Indian patients
    R Kumari, S Tiwari, M Atlani, A Anirudhan, SK Goel, A Kumar
    Biochemical Genetics 61 (4), 1548-1566 , 2023
    2023
    Citations: 15
  • Spotting of Volatile Signatures through GC-MS Analysis of Bacterial and Fungal Infections in Stored Potatoes ( Solanum tuberosum L.)
    A Kate, S Tiwari, JP Gujar, B Modhera, MK Tripathi, H Ray, A Ghosh, ...
    Foods 12 (10), 2083 , 2023
    2023
    Citations: 11
  • Natural and genetically-modified animal models to investigate pulmonary and extrapulmonary manifestations of COVID-19
    GGAK Shikha Tiwari
    International Reviews of Immunology , 2022
    2022
    Citations: 11
  • Isolation and characterization of phosphorus solubilizing bacteria from manganese mining area of Balaghat and Chhindwara
    S Dixit, KK AppuKuttan, R Shrivastava
    Current Science, 500-504 , 2017
    2017
    Citations: 11
  • Biological relevance of VOCs emanating from red onions infected with Erwinia (Pectobacterium) carotovora under different storage conditions
    S Tiwari, U Goswami, A Kate, B Modhera, MK Tripathi, D Mohapatra
    Postharvest Biology and Technology 184, 111761 , 2022
    2022
    Citations: 9
  • Study of human allergic milk whey protein from different mammalian species using computational method
    SJ Dixit, AK Kk, K Singh
    Bioinformation 8 (21), 1035 , 2012
    2012
    Citations: 9
  • Genetic characterization of sulphur and iron oxidizing bacteria in manganese mining area of Balaghat and Chhindwara, Madhya Pradesh, India.
    SJ Dixit, AK KK, RM Shrivastava
    Indian Journal of Biotechnology 17 (4) , 2018
    2018
    Citations: 8
  • miRNA genetic variations associated with the predisposition of oral squamous cell carcinoma in central Indian population
    S Tiwari, R Pandey, V Kumar, S Das, V Gupta, R Nema, A Kumar
    Non-Coding Rna Research 9 (4), 1333-1341 , 2024
    2024
    Citations: 5
  • Diagnostic, prognostic, and therapeutic role of MicroRNAs in head and neck cancer
    A Kumar, N Arya, S Tiwari, R Khan
    Elsevier , 2024
    2024
    Citations: 4
  • MicroRNA-based clinical trials for head and neck cancer
    R Kumar, S Tiwari, S Harilal
    Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck … , 2024
    2024
    Citations: 4
  • Development of microRNA as prognostic markers in head and neck cancer
    T Bhattacharya, S Tiwari, A Nandi, WY Lin, S Arumugam
    Diagnostic, prognostic, and therapeutic role of microRNAs in head and neck … , 2024
    2024
    Citations: 4
  • Artificial Neural Network Based Data Mining Approach for Human Heart Disease Prediction
    S Dixit, KK Appukuttan
    International Journal of Computer Engineering and Technology 5 (6), 136-142 , 2014
    2014
    Citations: 4
  • Association of single nucleotide polymorphism miRNA-146a (rs2910164) with increased predisposition to oral squamous cell carcinoma in central India population
    S Tiwari, R Pandey, V Kumar, S Das, V Gupta, S Vishwakarma, R Nema, ...
    Cancer Biomarkers 38 (2), 203-214 , 2023
    2023
    Citations: 3
  • microRNA Modulation: A Promising Combination Therapy for Cancer
    S Tiwari, D Bhatia, AK Yadav
    Springer Nature , 2026
    2026
    Citations: 1
  • Clinical Trials and Patent Updates of miRNA Therapy in Cancer
    R Mukherjee, A Tyagi, S Tiwari, A Arora
    microRNA Modulation: A Promising Combination Therapy for Cancer, 351-369 , 2026
    2026
    Citations: 1
  • Metabolic Engineering of Plant Volatiles in Fruits and Vegetables for Postharvest Quality Enhancement
    S Tiwari, P Bhatele
    Bioengineered Fruit and Vegetables, 307-328 , 2024
    2024
    Citations: 1
  • Glioblastoma Multiforme miRNA based Comprehensive Study to Validate Phytochemicals for Effective Treatment against Deadly Tumour through In Silico Evaluation
    RB Khan, S Tiwari, A Jarkharya, A Tiwari, R Chowdhary, A Shrivastava
    MicroRNA 13 (3), 240-250 , 2024
    2024
    Citations: 1
  • Electronic Nose for Fresh Produce Quality
    A Kate, S Tiwari, D Mohapatra
    Nondestructive Quality Assessment Techniques for Fresh Fruits and Vegetables … , 2022
    2022
    Citations: 1