Dr. Balwan Singh

@kiet.edu

Assistant Professor Pharmaceutics
KIET School of Pharmacy, KIET Group of Institutions, Delhi-NCR Ghaziabad UP India

Dr. Balwan Singh


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https://researchid.co/scorpiobalwan

EDUCATION

M Pharm., PhD (Pharmaceutical Sciences)

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacy, Pharmaceutical Science, Drug Discovery, General Pharmacology, Toxicology and Pharmaceutics
11

Scopus Publications

60

Scholar Citations

5

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • QbD-Driven Development and Evaluation of EGCG-Loaded Transfersomal Gel for Non-Melanoma Skin Carcinoma
    Singh B, Nanda S, and
    International Journal of Drug Delivery Technology, 2025
    The most common type of cancer is non-melanoma skin cancer (NMSC), necessitating the development of non-invasive and novel method of treatment. The current research study is focused on the design, development, and evaluation of a transfersomal gel loaded with epigallocatechin-3-gallate (EGCG), a bioactive compound with significant anti-cancer properties. After establishing anticancer properties of EGCG using cell lines and in silico studies, transfersomes were formulated using Box-Behnken Design (BBD). Optimization was done with three factors and three levels The optimized transfersomal gel exhibited significant physicochemical characteristics. Smaller V.S., improved Z.P. and high EE facilitated enhanced skin penetration as proved by in vitro and ex vivo studies using porcine skin. These findings demonstrated the potential of transfersomal formulation in enhancing the transdermal delivery of EGCG, paving the way for effective approaches for managing
  • Introduction to Nature's Arsenal: Harnessing Natural Compounds in Cancer Research
    Nature S Arsenal Against Cancer Harnessing the Power of Natural Compounds for Treatment and Prevention, 2024
  • The Future of Natural Compounds in Cancer Therapy: Promises and Prospects
    Nature S Arsenal Against Cancer Harnessing the Power of Natural Compounds for Treatment and Prevention, 2024
  • Immunomodulatory Potential of Natural Compounds in Cancer Immunity
    Nature S Arsenal Against Cancer Harnessing the Power of Natural Compounds for Treatment and Prevention, 2024
  • Lipid nanocarriers for pulmonary drug delivery
    Lipid Based Nanocarriers for Drug Delivery, 2024
  • Comparison Study of Aloin-Curcumin Nanoparticles by Taking 2 Different Ratios and Analyses by Using Drug Design Experimental Study
    Rishika . Chauhan, Balwan . Singh, Ram . Dayal, Anuj Malik . Malik
    International Journal of Drug Delivery Technology, 2024
    Numerous chemopreventive drugs like aloin and curcumin have demonstrated potential effects in cancer treatment; however, their efficacy is limited by low bioavailability. Thus, the primary goal of this research was to formulate a unique method by using the herbal drugs synergistically and improve the bioavailability of these anticancer drugs here, using the nanoprecipitation method for two well-active constituents of known natural herbal compounds. Aloin (AL)-curcumin (CUR) were co-loaded into polymeric nanoparticles made of poly (D, L-lactide-co-glycolide) and surfactant-polyvinyl alcohol, with the experiment’s response being evaluated using Stat-Ease software. To create dual-loaded nanoparticles containing aloin and curcumin, using different ratios sand optimizing the best formulation. (60:120). For aloin curcumin, optimize the better formulation with controlled release formulation having less than 100 nm size of particle and drug entrapment was 86.09% while for (60:60) of aloin -curcumin having 99.1 nm particle size of drug and encapsulation efficiency was 72.05%.
  • Oxalis corniculata and Ficus religiosa mitigates rotenone-induced Parkinson’s disease in Swiss Albino mice: Mechanistic insights and therapeutic potential
    Praveen Kumar, Himanshu Sachdeva, Sunishtha Kalra, Balwan Singh, Ram Dayal, et al.
    Journal of Applied Pharmaceutical Science, 2024
    Parkinson’s disease (PD) is a neurodegenerative disorder distinguished by the presence of progressive deterioration of the nervous system and is prevalent among the elderly population. The pathological hallmark of PD involves the accumulation of the protein alpha-synuclein and neuronal inflammation, which leads to the degeneration of dopaminergic (DAergic) neurons. In the present study, neuroprotective effect of combinational extract of Ficus religiosa (F. religiosa) and Oxalis corniculata (O. corniculata) L. in a mouse PD model. By giving Rotenone (ROT) on alternate days subcutaneously for 21 days, a disease model was generated. Extracts were administered individually as well as in combination orally 1 hour before ROT (1.5 mg/kg, s.c.) administration. On day 22nd, after sacrificing of animals neurochemical assays [total protein content (TPC), malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), nitrite (NO)], neurotransmitter analysis, and histology of the brain were performed. Results of the study showed a significant increase in the level of TPC, CAT, SOD, GSH, and dopamine in substantia nigra and a significant reduction of MDA, NO, and glutamate after administration of F. religiosa and O. corniculata in combination (200 + 500 mg/kg, p.o.) in a ROT induced model. This study demonstrated that a combination of F. religiosa and O. corniculata improved motor symptoms and reduced dopaminergic neuron death in mice challenged with ROT.
  • Pharmacokinetic Study of Aloin Nanoparticulate: Enhanced Oral Formulation Bioavailability
    Rishika Chauhan, Balwan Singh, MP Singh, Anuj Malik
    International Journal of Pharmaceutical Quality Assurance, 2024
    This research aimed to prepare and assess an aloin nanoparticle that might increase its oral bioavailability. Utilizing the nanoprecipitation process, aloin Poly lactic-co-glycolic acid (PLGA) nanoparticulate was formulated and studied for the best strategy based on their characteristics and in-vitro release. The aloin nanoparticle stability research was evaluated at room temperature for a duration of three months. Additionally, pharmacokinetic (PK) tests were analyzed by using various parameters and experiments done by taking female wistar albino rats, with weights of approximately (150–200 gm). The animal was appropriately given the proper housing according to the protocol and placed in a period of twelve hours day and night. The drug was administered for 72 hours at a dosage of 10 mg/kg. of all the aloin nanoformulations developed, the one with the best size of particles was 98.5 nm with an entanglement efficacy of 98.09%. The results show that when compared to pure aloin, aloin PLGA nanoparticulate has a higher bioavailability.
  • Formulation and Evaluation of Self-Emulsifying Drug Delivery Systems for Candesartan Cilexetil
    Balwan Singh, Manish Sharma
    International Journal of Pharmaceutical Sciences and Nanotechnology, 2022
    Introduction: Candesartan cilexetil is an angiotensin receptor blocker prescribed for hypertension management. However the drug belonging to BCS class II has low solubility and in turn low bioavailability. Lipid-based drug delivery systems are gaining wide attention in the field of pharmaceutical formulations owing to their potential to enhance the solubility of poorly aqueous soluble drugs.
 Objective: “Present” work aimed to formulate and evaluate Candesartan cilexetil loaded Self-emulsifying drug delivery systems (SEDDS) as a potential antihypertensive drug delivery system by improving its solubility
 Methods: Formulation of drug incorporated SEDDS was carried out using various oils, surfactants, and cosurfactants. Preliminary solubility studies in these excipients were performed followed by the construction of a Pseudoternary phase diagram for optimization of all three excipient concentrations. After this, SEDDS of Candesartan were formulated and evaluated for clarity, phase separation, drug content, % transmittance, globule size, freeze-thaw, in vitro dissolution studies, and particle size analyses.
 Results: Observation from preliminary solubility studies resulted in the selection of Acrosyl k-160 (oil phase), Labrafac PG (surfactant), and Transcutol-P (co-surfactant). A pseudo ternary phase diagram was constructed to optimize the concentration ranges of chosen oil, surfactant, and co-surfactant. In total twelve formulations were prepared and evaluated for various parameters. FTIR analysis indicated negligible drug excipient interaction. CF11 was identified as the optimal formulation based on the particle size of an average of about 50.2nm, drug content (98.66%), and in vitro release profile, with a drug release of 99.41±5.79 % after one hour. The formulations were also put through thirty-day thermodynamic stability studies and were found to be stable
 Conclusion: SEDDS can be formulated to improve the dissolution and oral bioavailability of the poorly water-soluble drug Candesartan, according to the findings of this study.
  • Formulation and evaluation of delayed release capsule of dimethyl fumarate with novel technology
    International Journal of Pharmaceutical Research, 2019
  • Dissolution enhancement: Dissolution enhancement through factorally designed porous solid dispersions
    Drug Development and Delivery, 2015

RECENT SCHOLAR PUBLICATIONS

  • The Steroid Solution? Navigating the Complex Role of Corticosteroids in Healing Wounds
    S Gautam, P Gupta, A Tiwari, R Kumar, B Singh
    2025
    Citations: 1
  • Phytopharmacological Insights into Ricinus communis: A Comprehensive Overview.
    SN Pandey, P Kumar, H Verma, S Durgapal, B Singh
    Pharmacognosy Research 17 (2) , 2025
    2025
    Citations: 1
  • Understanding Psoriasis: A Holistic Examination of A Complex Cutaneous Disorder
    P Gupta, B Sati, S Mehta, P Sharma, B Singh, S Sharma
    Journal of Neonatal Surgery 14 (26s), 1011 , 2025
    2025
  • A Perspective on Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis: A Surging Health Issue
    R Bhaskar, M Ola, R Patil, V Wagh, B Singh
    2025
  • Future of Natural Compounds in Cancer Therapy: Promises and Prospects
    K Srivastava, N., Valecha, P., Lal, S., Singh, B. \& Nagarajan
    Nature's Arsenal Against Cancer: Harnessing The Power Of Natural Compounds … , 2024
    2024
  • Introduction to Nature's Arsenal: Harnessing Natural Compounds in Cancer Research
    K Mehta, S., Singh, B., Rastogi, R. \& Nagarajan
    Nature's Arsenal Against Cancer: Harnessing The Power Of Natural Compounds … , 2024
    2024
  • Immunomodulatory Potential of Natural Compounds in Cancer Immunity
    V Singh, B., Varshney, C., Kalia, K., Srivastava, N., Singh, A., Nagarajan ...
    Harnessing the Power of Natural Compounds For Treatment And Prevention 1 … , 2024
    2024
  • Assessing the Protective Effects of PC-1 Formulation on Ethanol-Induced Gastric Ulcer Model in Wistar Rats: A Comprehensive Study
    BSMK Vijul Kumar Choudhary1, Shardendu Kumar Mishra1* Garima Kapoor2 Shubham ...
    Oriental Journal of Chemistry 40 (5), 1269-1280 , 2024
    2024
  • Oxalis corniculata and Ficus religiosa mitigates rotenone-induced Parkinson’s disease in Swiss Albino mice: Mechanistic insights and therapeutic potential
    P Kumar, H Sachdeva, S Kalra, B Singh, R Dayal, G Singh
    Journal of Applied Pharmaceutical Science 14 (6), 253-262 , 2024
    2024
    Citations: 6
  • DESIGN, DEVELOPMENT AND BIOLOGICAL EVALUATION OF NIFEDIPINE-LOADED ORAL FILM IN THE MANAGEMENT OF CARDIOVASCULAR DISEASES.
    R Bhaskar, RM Parjane, M Ola, B Singh, N Srivastava, R Dayal
    Biochemical & Cellular Archives 24 (1) , 2024
    2024
    Citations: 1
  • PHARMACOLOGICAL POTENTIAL OF LEMONGRASS OIL: A SYSTEMATIC REVIEW AND META ANALYSIS.
    T Chaudhary, C Varshney, A Khan, B Singh, S Jainer, AK Tiwari, ...
    Biochemical & Cellular Archives 24 (1) , 2024
    2024
    Citations: 5
  • Pharmacokinetic Study of Aloin Nanoparticulate: Enhanced Oral Formulation Bioavailability
    R Chauhan, B Singh, MP Singh, A Malik
    IJPQA 15 (1), 94-100 , 2024
    2024
    Citations: 3
  • Solid Dispersion Approach For Improving Dissolution And Solubility Of Telmisartan Orally Disintegrating Tablets
    V Sharma, B Singh, A Pathak, A Bhardwaj
    2024
  • Lipid Nanocarriers for Pulmonary Drug Delivery
    H Sachdeva, S Kalra, B Singh, P Kumar, G Singh
    Lipid Based Nanocarriers for Drug Delivery, 205 , 2024
    2024
  • Comparison Study of Aloin-Curcumin Nanoparticles by Taking 2 Different Ratios and Analyses by Using Drug Design Experimental Study
    R Chauhan, B Singh, R Dayal, A Malik
    Technology 14 (3), 1377-1383 , 2024
    2024
    Citations: 2
  • Spanlastics: An innovative formulation strategy in pharmaceutical drug delivery
    A Khan, C Varshney, T Chaudhary, B Singh, K Nagarajan
    World J Pharmceut Res 12 (20), 219-34 , 2023
    2023
    Citations: 7
  • Targeting Trauma-Induced Endocannabinoid System Dysfunction: A Novel Neuroprotective Approach For Traumatic Brain Injury
    GS Praveen Kumar1, Sunishtha Kalra1, Himanshu Sachdeva1, Balwan Singh2 ...
    Latin American Journal of Pharmacy 42 (3), 1562-1578 , 2023
    2023
  • Neuroprotective Effects Of Garcinia Morella And Ficus Religiosa Extract Against Rotenone-Induced Mouse Model Of Parkinson's In Swiss Albino Mice
    GS Manish Yadav1, Sunishtha Kalra1, Himanshu Sachdeva1, Balwan Singh1,2 ...
    Latin American Journal of Pharmacy 42 (3), 1579-1591 , 2023
    2023
  • EGCG: RECENT FORMULATION DEVELOPMENTS, CHALLENGES AND OPPORTUNITIES
    KN Balwan Singh, Sanju Nanda, Noopur Srivastava, Kamini Kalia
    European Chemical Bulletin 12 (6), 1651-1660 , 2023
    2023
  • REVIEW ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM: TREATMENT OF HELICOBACTER PYLORI INFECTIONS
    2 Aarati Maurya1 , N. G. Raghavendra Rao1 *, Anuj Pathak1 , Balwan Singh1 ...
    Eur. Chem. Bull. 2023 12 ((Regular Issue 4)), 1176 – 1195 , 2023
    2023

MOST CITED SCHOLAR PUBLICATIONS

  • The future of non-invasive ways to treat cancer
    SS Imam
    Int J Pharm Sci& Res2021 12 (8), 4684-96 , 2021
    2021
    Citations: 23
  • Spanlastics: An innovative formulation strategy in pharmaceutical drug delivery
    A Khan, C Varshney, T Chaudhary, B Singh, K Nagarajan
    World J Pharmceut Res 12 (20), 219-34 , 2023
    2023
    Citations: 7
  • Oxalis corniculata and Ficus religiosa mitigates rotenone-induced Parkinson’s disease in Swiss Albino mice: Mechanistic insights and therapeutic potential
    P Kumar, H Sachdeva, S Kalra, B Singh, R Dayal, G Singh
    Journal of Applied Pharmaceutical Science 14 (6), 253-262 , 2024
    2024
    Citations: 6
  • Unlocking radiance: the dynamic duo of flaxseeds and aloe vera in hair mask for bioactive brilliance
    N Tyagi, A Tyagi, R Rastogi, B Singh, K Nagarajan
    Proteins 22, 29-22 , 2023
    2023
    Citations: 6
  • PHARMACOLOGICAL POTENTIAL OF LEMONGRASS OIL: A SYSTEMATIC REVIEW AND META ANALYSIS.
    T Chaudhary, C Varshney, A Khan, B Singh, S Jainer, AK Tiwari, ...
    Biochemical & Cellular Archives 24 (1) , 2024
    2024
    Citations: 5
  • Pharmacokinetic Study of Aloin Nanoparticulate: Enhanced Oral Formulation Bioavailability
    R Chauhan, B Singh, MP Singh, A Malik
    IJPQA 15 (1), 94-100 , 2024
    2024
    Citations: 3
  • Comparison Study of Aloin-Curcumin Nanoparticles by Taking 2 Different Ratios and Analyses by Using Drug Design Experimental Study
    R Chauhan, B Singh, R Dayal, A Malik
    Technology 14 (3), 1377-1383 , 2024
    2024
    Citations: 2
  • Formulation and Evaluation of Delayed Release Capsule of Dimethyl Fumarate with Novel Technology
    RK Anjali Kumari, Balwan Singh
    International Journal of Pharmaceutical Research 11 (4), 745-753 , 2019
    2019
    Citations: 2
  • Pyrazoline synthesis through a chalcone intermediate
    MH Ramanpreet walia, Balwan Singh
    International Journal of Drug Regulatory Affairs 2 ((4)), 59-62 , 2014
    2014
    Citations: 2
  • The Steroid Solution? Navigating the Complex Role of Corticosteroids in Healing Wounds
    S Gautam, P Gupta, A Tiwari, R Kumar, B Singh
    2025
    Citations: 1
  • Phytopharmacological Insights into Ricinus communis: A Comprehensive Overview.
    SN Pandey, P Kumar, H Verma, S Durgapal, B Singh
    Pharmacognosy Research 17 (2) , 2025
    2025
    Citations: 1
  • DESIGN, DEVELOPMENT AND BIOLOGICAL EVALUATION OF NIFEDIPINE-LOADED ORAL FILM IN THE MANAGEMENT OF CARDIOVASCULAR DISEASES.
    R Bhaskar, RM Parjane, M Ola, B Singh, N Srivastava, R Dayal
    Biochemical & Cellular Archives 24 (1) , 2024
    2024
    Citations: 1
  • Formulation and Evaluation of Self-Emulsifying Drug Delivery Systems for Candesartan Cilexetil
    MS Balwan Singh*
    International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN … , 2022
    2022
    Citations: 1
  • Understanding Psoriasis: A Holistic Examination of A Complex Cutaneous Disorder
    P Gupta, B Sati, S Mehta, P Sharma, B Singh, S Sharma
    Journal of Neonatal Surgery 14 (26s), 1011 , 2025
    2025
  • A Perspective on Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis: A Surging Health Issue
    R Bhaskar, M Ola, R Patil, V Wagh, B Singh
    2025
  • Future of Natural Compounds in Cancer Therapy: Promises and Prospects
    K Srivastava, N., Valecha, P., Lal, S., Singh, B. \& Nagarajan
    Nature's Arsenal Against Cancer: Harnessing The Power Of Natural Compounds … , 2024
    2024
  • Introduction to Nature's Arsenal: Harnessing Natural Compounds in Cancer Research
    K Mehta, S., Singh, B., Rastogi, R. \& Nagarajan
    Nature's Arsenal Against Cancer: Harnessing The Power Of Natural Compounds … , 2024
    2024
  • Immunomodulatory Potential of Natural Compounds in Cancer Immunity
    V Singh, B., Varshney, C., Kalia, K., Srivastava, N., Singh, A., Nagarajan ...
    Harnessing the Power of Natural Compounds For Treatment And Prevention 1 … , 2024
    2024
  • Assessing the Protective Effects of PC-1 Formulation on Ethanol-Induced Gastric Ulcer Model in Wistar Rats: A Comprehensive Study
    BSMK Vijul Kumar Choudhary1, Shardendu Kumar Mishra1* Garima Kapoor2 Shubham ...
    Oriental Journal of Chemistry 40 (5), 1269-1280 , 2024
    2024
  • Solid Dispersion Approach For Improving Dissolution And Solubility Of Telmisartan Orally Disintegrating Tablets
    V Sharma, B Singh, A Pathak, A Bhardwaj
    2024