Alceu Totti Silveira Junior
@usp.br
Scopus Publications
- Fast pH-Driven Solubilization Method of Realgar (As4S4) to Reduce the Toxicity of Arsenic [As(III)] for Medicinal Purposes
Bojana Lucic, Douglas Santana Franciscato, Helton Pereira Nogueira, Lara Gallucci, Alceu Totti Silveira Junior, et al.
Advanced Science, 2025
Acute promyelocytic leukemia (APL) accounts for 5–15% of acute myeloid leukemia cases. It is typically characterized by the (15;17) chromosomal translocation, producing the pathogenic retinoic acid receptor (RAR) alpha/promyelocytic leukemia (PML) fusion protein. Recently, remission of APL has been achieved using the first chemotherapy‐independent oral drug regimen in anticancer therapy, consisting of all‐trans retinoic acid (targeting RARalpha) and the arsenic sulfide realgar (targeting PML). However, clinical adoption of realgar and the characterization of its active breakdown products have been hampered by its poor solubility. Here, a scalable pH/temperature‐based process is described that partially mimics gut transition, achieving fast and reproducible solubilization of realgar. Six different spectroscopic and spectrometric techniques are employed to investigate solubilized realgar. Furthermore, it is shown that solubilized realgar targets PML, displaying wider in vitro therapeutic indices and lower off‐target effects than arsenic trioxide, the current APL standard of care. Moreover, in line with evidence of an interplay between PML and HIV persistence, solubilized realgar can disrupt HIV latency, the main barrier to an HIV/AIDS cure, in CD4 T cells of people living with HIV. These findings may open avenues for streamlining realgar solubilization and designing less toxic, orally administrable arsenic‐based therapies. - Unraveling the spectroscopic/electrochemical behavior of a tetraruthenated zinctetrapyridylporphyrazine complex
Marcos M. Toyama, Sergio H. Toma, Lucas C. V. Rodrigues, Luca Blois, Hermi F. Brito, et al.
Journal of Porphyrins and Phthalocyanines, 2025
A comparison of the chemistry of the tetraruthenated zinctetrapyridilporphyrin and zinctetrapyridylporphyrazine species has been performed, aiming to improve the understanding of the electronic coupling (or back-bonding) between the macrocyclic center and the peripheral [Ru(bipy)2Cl][Formula: see text] complexes. In the case of the supramolecular tetrapyridylporphyrins, the bridging pyridyl groups are located at the meso-carbon position so that their rotational properties decrease the electronic coupling between the peripheral complexes and the porphyrin center. However, in the tetrapyridylporphyrazine system, the interaction with [Formula: see text]-backbonding Ru(II) complexes is greatly enhanced because the pyridyl groups are fused into the macrocyclic ring with stronger electron acceptor properties. Consequently, the fluorescence emission from the porphyrazine center can be directly pumped from the peripheral complexes by exciting in the Ru[Formula: see text]ZnTPyPz([Formula: see text]*) MLCT band, in contrast with the analogous porphyrin species. The electrochemical behavior of the ZnTRuPyPz complex exhibits the characteristic redox waves of [Ru[Formula: see text](bipy)2Cl] at 1.00 V, showing a 0.080 V increase in comparison with the ZnTRuPyP complex, consistent with stronger [Formula: see text]-back bonding interactions with the porphyrazine center. This observation was also corroborated by the pronounced spectroelectrochemical changes in the porphyrazine Q bands induced by the oxidation of the peripheral ruthenium complexes to Ru(III). The spectroscopic and electrochemical results indicate that the porphyrazines can be better than the porphyrins for developing electronically conjugated supramolecular systems. - New insights on the Jacobsite mineral from Bahia and related synthetic manganese-ferrite nanoparticles
LUCAS F. QUARTAROLLI, FERNANDO M. DE MELO, JOANIEL M. MARTINS, ALCEU T. SILVEIRA-JUNIOR, MARCELO NAKAMURA, et al.
Anais Da Academia Brasileira De Ciencias, 2024 - Improving the lithium recovery using leached beta-spodumene residues processed by magnetic nanohydrometallurgy
Lucas F. Quartarolli, Bruno B.N.S. Brandão, Alceu T. Silveira- Júnior, Marcelo Nakamura, Henrique E. Toma
Minerals Engineering, 2022 - Overcoming lithium analysis difficulties with a simple colorimetric/spectrophotometric method
Lucas F. Quartarolli, Alceu T. Silveira, Henrique E. Toma
Analytical Methods, 2021
The analytical determination of lithium ions can be performed colorimetrically with a smartphone. - Accessibility and strength of H-acceptor hydroxyls of ordered mesoporous silicas probed by pyridine donor
Mayara R. Alves, Mateus F. Paiva, Pablo T. A. Campos, Elon F. de Freitas, Maria Clara H. Clemente, et al.
Journal of Porous Materials, 2021
Ordered mesoporous silica (OMS) is an important and useful material for a variety of applications, including catalysis, adsorption, sensing and controlled drug delivery. The surface chemistry and the silanol groups on OMS pores are key properties for the potential modification and application of this material. This research aimed to synthesize (using standard protocols) and differentiate the accessibility and strength of the H-acceptor Si–OH from FDU-12, SBA-16, MCM-41 and SBA-15 by pyridine (Py) donor, where the first two have cubic pore structures and the last two have hexagonal pore structures. Donor–acceptor properties were assessed by calculation of the surface Si–OH densities by thermogravimetry (TG), H2O-TPD/MS, and 29Si MAS and CP/MAS NMR. The nature of the Si–OH groups on these materials was determined to be hydrogen-bonding sites using FT-IR spectroscopy of Py adsorption. The reactivity of these silanol groups was probed by Py-TG and slurry microcalorimetry of Py adsorption in cyclohexane. Differences in accessibility and reactivity were discussed considering the total potential sites on the surface (nOH) versus the actual sites that can react with the Py molecule (nPy). By using microcalorimetry, it was possible to quantitatively distinguish the strength of the sites: The acidity order was approximately the same as the relative amount of silanol groups (Si–OH) and Py on the surface of the OMS materials (αPy): FDU-12 > MCM-41 ≥ SBA-16 > SBA-15. - Langmuir Isotherms for Functionalized Superparamagnetic Nanoparticles with Cobalt(II) Ions Based on Zeta Potentials
Felipe F. Kaid, Alceu T. Silveira-Junior, Henrique E. Toma
ACS Applied Nano Materials, 2020 - Zeolite-SPION nanocomposite for ammonium and heavy metals removal from wastewater
Helton Nogueira, Sergio Toma, Alceu Silveira Jr., Koiti Araki
Journal of the Brazilian Chemical Society, 2020
Minimizing the emission of industrial effluents and realizing the recovery/extraction of key elements such as the rare earths from low concentration solutions, or during water decontamination processes, are some of the biggest challenges of modern society. Accordingly, the preparation and characterization of a low cost recyclable and reusable superparamagnetic iron oxide nanoparticles (SPION)/zeolite nanocomposite (Zmag) is described, and the possibility of their use for removal of heavy metals and ammonium/ammonia is discussed, generating water whose quality is in compliance with the more strict modern environmental laws. Such materials are suitable for realization of a more efficient dispersion method for adsorption in combination with magnetically aided concentration/separation processes for removal of contaminants. In fact, Zmag was shown to efficiently remove Pb and Hg, as well as NH4 from water, generating effluents that can be directly disposed in water bodies according to the current environmental law requirements, as stated by EPA (North America Environmental Protection Agency). That nanocomposite material has a competitive production cost and allowed a cutback in the nitrogen (NH3) content from 300 mg L (diluted slurry source) to less than 36 mg L. Furthermore, Zmag demonstrated high capacity to concentrate and recover in a cyclic way La. - On the Amazing Reactivity of the Ranelate Ion: New Applications of an Old Antiosporotic Drug
Julio C. Rocha, Luca M. Sihn, Mayara K. Uchiyama, Marcos A. Ribeiro, Maurício P. Franco, et al.
Chemistryselect, 2019 - Magnetic behavior of superparamagnetic nanoparticles containing chelated transition metal ions
Fernando M. Melo, Alceu T. Silveira, Lucas F. Quartarolli, Felipe F. Kaid, Daniel R. Cornejo, et al.
Journal of Magnetism and Magnetic Materials, 2019 - Efficient Cr(VI) removal from wastewater by activated carbon superparamagnetic composites
Helton P. Nogueira, Sergio H. Toma, Alceu T. Silveira, Alexandrina A.C. Carvalho, Alexandre M. Fioroto, et al.
Microchemical Journal, 2019 - Raman studies of bis(phenylterpyrazine)iron(II) and supramolecular species with pentacyanidoferrate(II) ions
Ana Mangoni, Bruno Brandão, Jorge Shinohara, Alceu Silveira, Marcelo Nakamura, et al.
Quimica Nova, 2019 - Green processing of strategic elements based on magnetic nanohydrometallurgy
Ulisses Condomitti, Sabrina Almeida, Alceu Silveira, Fernando de Melo, Henrique Toma
Journal of the Brazilian Chemical Society, 2018 - Bisphenol-A electronalysis employing carbon coated superparamagnetic nanoparticles for adsorption and magnetic concentration onto screen-printed electrodes
Ulisses Condomitti, Alceu T. Silveira Junior, João V. Mattioni, Leonardo H. Hasimoto, Henrique E. Toma
Journal of Electroanalytical Chemistry, 2017 - Introducing Environmental and Sustainable Chemistry Topics Using a Nanotechnology Approach: Removing Hazardous Metal Ions by Means of Humic-Acid-Modified Superparamagnetic Nanoparticles
Delmárcio Gomes da Silva, Fernando Menegatti de Melo, Alceu Totti Silveira, Bruno Constancio da Cruz, Caio Cesar Pestana Prado, et al.
Journal of Chemical Education, 2016 - Silver recovery using electrochemically active magnetite coated carbon particles
Ulisses Condomitti, Alceu T. Silveira, George W. Condomitti, Sergio H. Toma, K. Araki, et al.
Hydrometallurgy, 2014 - Magnetic nanohydrometallurgy: A promising nanotechnological approach for metal production and recovery using functionalized superparamagnetic nanoparticles
Ulisses Condomitti, Andre Zuin, Alceu T. Silveira, Koiti Araki, Henrique E. Toma
Hydrometallurgy, 2012 - Superparamagnetic carbon electrodes: A versatile approach for performing magnetic coupled electrochemical analysis of mercury ions
Ulisses Condomitti, Andre Zuin, Alceu T. Silveira, Sergio H. Toma, Koiti Araki, et al.
Electroanalysis, 2011 - Direct use of superparamagnetic nanoparticles as electrode modifiers for the analysis of mercury ions from aqueous solution and crude petroleum samples
Ulisses Condomitti, Andre Zuin, Alceu T. Silveira, Koiti Araki, Henrique E. Toma
Journal of Electroanalytical Chemistry, 2011
RECENT SCHOLAR PUBLICATIONS
- Designing Magnetic Nanoparticles with Polydopamine and Folic Acid for the Capture of Strategic Metals and Drug Delivery
FMF Lemos, NMPS Ricardo, GR Ramos, JV Mattioni, AL Hennemann, ...
Journal of Nanoparticle Research 27 (12), 326 , 2025
2025
Citations: 1 - Unraveling the spectroscopic/electrochemical behavior of a tetraruthenated zinctetrapyridylporphyrazine complex
MM Toyama, SH Toma, LCV Rodrigues, L Blois, HF Brito, ...
Journal of Porphyrins and Phthalocyanines 29 (01n02), 84-92 , 2025
2025
Citations: 1 - Improving the lithium recovery using leached beta-spodumene residues processed by magnetic nanohydrometallurgy
LF Quartarolli, BBNS Brandão, AT Silveira-Júnior, M Nakamura, HE Toma
Minerals Engineering 186, 107747 , 2022
2022
Citations: 16 - Experimental data for green synthesis of Zn-abietate complex from natural resin
JS Correa, JO Primo, C Bittencourt, DFL Horsth, E Radovanovic, ...
Data in Brief 40, 107776 , 2022
2022
Citations: 6 - Ecofriendly synthesis of Zn-abietate pigment derived from Pinus elliott resin and their antibacterial activity against S. aureus and E. coli
J Correa, J de Oliveira Primo, C Bittencourt, D Horsth, E Radovanovic, ...
Dyes and Pigments 197 , 2022
2022 - Ecofriendly synthesis of Zn-abietate complex derived from Pinus elliottii resin and its application as an antibacterial pigment against S. aureus and E. coli
JS Correa, JO Primo, C Bittencourt, DFL Horsth, E Radovanovic, ...
Dyes and Pigments 197, 109946 , 2022
2022
Citations: 7 - Overcoming lithium analysis difficulties with a simple colorimetric/spectrophotometric method
LF Quartarolli, AT Silveira, HE Toma
Analytical Methods 13 (32), 3627-3631 , 2021
2021
Citations: 8 - Accessibility and strength of H-acceptor hydroxyls of ordered mesoporous silicas probed by pyridine donor
MR Alves, MF Paiva, PTA Campos, EF de Freitas, MCH Clemente, ...
Journal of Porous Materials 28 (2), 323-335 , 2021
2021
Citations: 15 - Synthesis and characterization of GO-H 3 BO 3 composite for improving single-sensor impedimetric olfaction
MFP Da Silva, EJP Souza, ATS Junior, MR Cavallari, LG Paterno, ...
Journal of Materials Science: Materials in Electronics 31 (17), 14443-14453 , 2020
2020
Citations: 5 - Uso de Nanopartículas Superparamagnéticas na Revelação de mpressões Dígito-Papilares Latentes
U Condomitti, E Cavalcante, P Pacheco, ATS Junior, HE Toma
Brazilian Journal of Forensic Sciences, Medical Law and Bioethics 9 (3), 282-291 , 2020
2020 - Zeolite-SPION nanocomposite for ammonium and heavy metals removal from wastewater
HP Nogueira, SH Toma, AT Silveira Jr, K Araki
Journal of the Brazilian Chemical Society 31, 2342-2350 , 2020
2020
Citations: 15 - On the amazing reactivity of the ranelate ion: new applications of an old antiosporotic drug
JC Rocha, LM Sihn, MK Uchiyama, MA Ribeiro, MP Franco, AAC Braga, ...
ChemistrySelect 4 (47), 13926-13931 , 2019
2019
Citations: 11 - Langmuir Isotherms for Functionalized Superparamagnetic Nanoparticles with Cobalt (II) Ions Based on Zeta Potentials
FF Kaid, AT Totti Silveira Junior, HE Toma
ACS Applied Nano Materials , 2019
2019
Citations: 14 - Magnetic behavior of superparamagnetic nanoparticles containing chelated transition metal ions
FM Melo, AT Silveira, LF Quartarolli, FF Kaid, DR Cornejo, HE Toma
Journal of Magnetism and Magnetic Materials 487, 165324 , 2019
2019
Citations: 26 - Efficient Cr (VI) removal from wastewater by activated carbon superparamagnetic composites
HP Nogueira, SH Toma, AT Silveira, AAC Carvalho, AM Fioroto, K Araki
Microchemical Journal 149, 104025 , 2019
2019
Citations: 32 - RAMAN STUDIES OF BIS (PHENYLTERPYRAZINE) IRON (II) AND SUPRAMOLECULAR SPECIES WITH PENTACYANIDOFERRATE (II) IONS
AP Mangoni, BBNS Brandão, JS Shinohara, AT Silveira, M Nakamura, ...
Química Nova 42 (9), 1020-1028 , 2019
2019
Citations: 8 - Process for obtaining nanocomposites, nanocomposite, method of capture and retrieval of a solubilized and/or dispersed material in organic or inorganic medium, method of …
K Araki, UC EPAMINO, ATS JUNIOR, SH TOMA, HE TOMA
US Patent 10,086,358 , 2018
2018
Citations: 1 - Green processing of strategic elements based on magnetic nanohydrometallurgy
U Condomitti, SN Almeida, AT Silveira Jr, FM Melo, HE Toma
Journal of the Brazilian Chemical Society 29 (5), 948-959 , 2018
2018
Citations: 27 - Bisphenol-A electronalysis employing carbon coated superparamagnetic nanoparticles for adsorption and magnetic concentration onto screen-printed electrodes
U Condomitti, ATS Junior, JV Mattioni, LH Hasimoto, HE Toma
Journal of Electroanalytical Chemistry 799, 299-303 , 2017
2017
Citations: 5 - Carbono modificado com nanopartículas superparamagnéticas como materiais estratégicos em Química Analítica e Ambiental
AT Silveira Junior
Universidade de São Paulo , 2017
2017
Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
- Magnetic nanohydrometallurgy: A promising nanotechnological approach for metal production and recovery using functionalized superparamagnetic nanoparticles
U Condomitti, A Zuin, AT Silveira, K Araki, HE Toma
Hydrometallurgy 125, 148-151 , 2012
2012
Citations: 52 - Silver recovery using electrochemically active magnetite coated carbon particles
U Condomitti, AT Silveira, GW Condomitti, SH Toma, K Araki, HE Toma
Hydrometallurgy 147, 241-245 , 2014
2014
Citations: 42 - Efficient Cr (VI) removal from wastewater by activated carbon superparamagnetic composites
HP Nogueira, SH Toma, AT Silveira, AAC Carvalho, AM Fioroto, K Araki
Microchemical Journal 149, 104025 , 2019
2019
Citations: 32 - Green processing of strategic elements based on magnetic nanohydrometallurgy
U Condomitti, SN Almeida, AT Silveira Jr, FM Melo, HE Toma
Journal of the Brazilian Chemical Society 29 (5), 948-959 , 2018
2018
Citations: 27 - Magnetic behavior of superparamagnetic nanoparticles containing chelated transition metal ions
FM Melo, AT Silveira, LF Quartarolli, FF Kaid, DR Cornejo, HE Toma
Journal of Magnetism and Magnetic Materials 487, 165324 , 2019
2019
Citations: 26 - Direct use of superparamagnetic nanoparticles as electrode modifiers for the analysis of mercury ions from aqueous solution and crude petroleum samples
U Condomitti, A Zuin, AT Silveira, K Araki, HE Toma
Journal of Electroanalytical Chemistry 661 (1), 72-76 , 2011
2011
Citations: 23 - Superparamagnetic carbon electrodes: a versatile approach for performing magnetic coupled electrochemical analysis of mercury ions
U Condomitti, A Zuin, AT Silveira, SH Toma, K Araki, HE Toma
Electroanalysis 23 (11), 2569-2573 , 2011
2011
Citations: 19 - Introducing environmental and sustainable chemistry topics using a nanotechnology approach: removing hazardous metal ions by means of humic-acid-modified superparamagnetic …
DG da Silva, FM de Melo, AT Silveira Jr, BC da Cruz, CCP Prado, ...
Journal of Chemical Education 93 (11), 1929-1934 , 2016
2016
Citations: 18 - Improving the lithium recovery using leached beta-spodumene residues processed by magnetic nanohydrometallurgy
LF Quartarolli, BBNS Brandão, AT Silveira-Júnior, M Nakamura, HE Toma
Minerals Engineering 186, 107747 , 2022
2022
Citations: 16 - Accessibility and strength of H-acceptor hydroxyls of ordered mesoporous silicas probed by pyridine donor
MR Alves, MF Paiva, PTA Campos, EF de Freitas, MCH Clemente, ...
Journal of Porous Materials 28 (2), 323-335 , 2021
2021
Citations: 15 - Zeolite-SPION nanocomposite for ammonium and heavy metals removal from wastewater
HP Nogueira, SH Toma, AT Silveira Jr, K Araki
Journal of the Brazilian Chemical Society 31, 2342-2350 , 2020
2020
Citations: 15 - Langmuir Isotherms for Functionalized Superparamagnetic Nanoparticles with Cobalt (II) Ions Based on Zeta Potentials
FF Kaid, AT Totti Silveira Junior, HE Toma
ACS Applied Nano Materials , 2019
2019
Citations: 14 - On the amazing reactivity of the ranelate ion: new applications of an old antiosporotic drug
JC Rocha, LM Sihn, MK Uchiyama, MA Ribeiro, MP Franco, AAC Braga, ...
ChemistrySelect 4 (47), 13926-13931 , 2019
2019
Citations: 11 - Overcoming lithium analysis difficulties with a simple colorimetric/spectrophotometric method
LF Quartarolli, AT Silveira, HE Toma
Analytical Methods 13 (32), 3627-3631 , 2021
2021
Citations: 8 - RAMAN STUDIES OF BIS (PHENYLTERPYRAZINE) IRON (II) AND SUPRAMOLECULAR SPECIES WITH PENTACYANIDOFERRATE (II) IONS
AP Mangoni, BBNS Brandão, JS Shinohara, AT Silveira, M Nakamura, ...
Química Nova 42 (9), 1020-1028 , 2019
2019
Citations: 8 - Ecofriendly synthesis of Zn-abietate complex derived from Pinus elliottii resin and its application as an antibacterial pigment against S. aureus and E. coli
JS Correa, JO Primo, C Bittencourt, DFL Horsth, E Radovanovic, ...
Dyes and Pigments 197, 109946 , 2022
2022
Citations: 7 - Experimental data for green synthesis of Zn-abietate complex from natural resin
JS Correa, JO Primo, C Bittencourt, DFL Horsth, E Radovanovic, ...
Data in Brief 40, 107776 , 2022
2022
Citations: 6 - Synthesis and characterization of GO-H 3 BO 3 composite for improving single-sensor impedimetric olfaction
MFP Da Silva, EJP Souza, ATS Junior, MR Cavallari, LG Paterno, ...
Journal of Materials Science: Materials in Electronics 31 (17), 14443-14453 , 2020
2020
Citations: 5 - Bisphenol-A electronalysis employing carbon coated superparamagnetic nanoparticles for adsorption and magnetic concentration onto screen-printed electrodes
U Condomitti, ATS Junior, JV Mattioni, LH Hasimoto, HE Toma
Journal of Electroanalytical Chemistry 799, 299-303 , 2017
2017
Citations: 5 - Designing Magnetic Nanoparticles with Polydopamine and Folic Acid for the Capture of Strategic Metals and Drug Delivery
FMF Lemos, NMPS Ricardo, GR Ramos, JV Mattioni, AL Hennemann, ...
Journal of Nanoparticle Research 27 (12), 326 , 2025
2025
Citations: 1
