Lidawani Lambuk

@ukm.edu.my

Lecturer, Program of Optometry and Vision Science
Universiti Kebangsaan Malaysia

Lidawani Lambuk


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https://researchid.co/lidawanilambuk

RESEARCH INTERESTS

Ocular pharmacology
27

Scopus Publications

603

Scholar Citations

13

Scholar h-index

15

Scholar i10-index

Scopus Publications

  • Nanotherapeutic potential in glaucoma associated ocular cancers
    Lidawani Lambuk, Muhammad Zulfiqah Sadikan, Mohd Aizuddin Mohd Lazaldin, Fatmawati Lambuk, Ramlah Kadir, Norzila Ismail, Rohimah Mohamud
    Discover Oncology, 2026
    Glaucoma-associated ocular cancers, including uveal melanoma and retinoblastoma, share overlapping pathological mechanisms that complicate diagnosis and treatment. Conventional imaging techniques, such as optical coherence tomography, often fail to distinguish glaucomatous neurodegeneration from tumour-induced damage, while standard chemotherapy and radiotherapy may exacerbate glaucoma progression. These diagnostic and therapeutic challenges highlight the urgent need for integrated management strategies. Recent advances in nanotechnology offer innovative solutions, with nanotherapeutics enabling targeted drug delivery, enhanced imaging contrast, and combined diagnostic–therapeutic (“theranostic”) capabilities. Various nanoparticle platforms have shown promise in improving ocular drug bioavailability, precision targeting, and real-time disease monitoring. This review synthesizes current progress in nanomedicine for glaucoma-associated cancers, emphasizing multifunctional nanoparticles that concurrently support tumour suppression and neuroprotection. Despite encouraging preclinical findings, significant challenges remain, including limited penetration across ocular barriers, uncertain long-term biocompatibility, and complex regulatory requirements. Continued interdisciplinary research integrating nanotechnology with gene editing and vector-based delivery systems may pave the way for personalized, vision-preserving therapies that redefine the treatment paradigm for glaucoma-associated ocular malignancies.
  • Prevalence and risk factors of hepatitis B vaccine non-response in hemodialysis patients: a narrative review
    Nor A Nordin, Muhammad Z Sadikan, Lidawani Lambuk, Fatmawati Lambuk, Aina AM Noor, Rohimah Mohamud, Nik HHN Hashim
    Journal of Infection in Developing Countries, 2026
    Hepatitis B virus (HBV) infection poses a significant threat to public health, with hemodialysis patients facing an exceptionally high risk due to their compromised immune systems and exposure to blood products. While vaccination is the cornerstone of HBV prevention, hemodialysis patients often exhibit inadequate immune responses to the vaccine, jeopardizing their protection. This narrative review comprehensively evaluates the prevalence of non-response to HBV vaccination among hemodialysis patients and identifies associated factors. Drawing on data from various sources, the review analyzes demographics, clinical characteristics, and vaccination protocols to shed light on the critical determinants of vaccine failure. The analysis reveals significant variability in vaccine response rates among hemodialysis patients, with factors such as age, comorbidities, dialysis duration, and nutritional status playing pivotal roles. Additionally, vaccine type, dosage, and administration schedule influence immunogenicity. The findings provide critical insights into optimizing HBV vaccination strategies for hemodialysis non-responders by identifying underlying risk factors, thereby contributing to enhanced public health outcomes.
  • Role of dendritic cells and B cells in the skin of imiquimod (IMQ)-induced psoriasis-like mouse model
    Aina Akmal Mohd Noor, Lidawani Lambuk, Farizan Ahmad, Maryam Azlan, Norhanani Mohd Redzwan
    Peerj, 2026
    Background Psoriasis is a chronic inflammatory skin disease traditionally characterized by T cell-mediated immune responses. However, dendritic cells (DCs) and B cells also contribute to immune regulation in psoriasis. Their role in disease progression remains underexplored. Methods This study utilized an imiquimod (IMQ)-induced psoriasis-like mouse model to investigate DC and B cell dynamics at different stages of disease progression (day 3, day 5 and day 7). Skin lesions were evaluated using the Psoriasis Area and Severity Index (PASI) and histological analysis. Flow cytometry was performed to assess the expression of CD11c + MHCII + DCs and CD19 + CD38 + B cells, while gene expression analysis using reverse transcriptase polymerase chain reaction (RT-PCR) of CD11c, H2-Aa, B cell activating factor (BAFF), interleukin (IL)-10, IL-6 and CXCR5 was conducted to elucidate immune modulation within the psoriasis skin microenvironment. Results IMQ application induced progressive skin thickening, erythema and scaling, with PASI scores significantly increased at day 7 compared to controls ( p = 0.002), reflecting pronounced inflammation. Histological analysis revealed epidermal hyperplasia, hyperkeratosis and dermal immune cell infiltration. Skin CD11c + MHCII + DCs were significantly elevated at day 3 ( p < 0.01), corresponding with upregulation of CD11c and H2-Aa genes, while CD19 + CD38 + B cells expanded at later stages, peaking at day 7 ( p < 0.0001), associated with increased BAFF , IL-10 , IL-6 and CXCR5 expression. A reduction in circulating B cells was observed alongside increased skin infiltration, suggesting a possible redistribution associated with inflammation. Conclusion Early DC activation corresponded with the initiation phase of inflammation, while the later expansion of B cells appeared to coincide with sustained inflammatory activity and disease progression. The coordinated presence of DCs and B cells in the skin microenvironment may influence disease severity and pathogenesis, which could provide fundamental insights for future investigations into potential therapeutic strategies.
  • Navigating the landscape of hepatitis B virus reactivation in HBsAg-positive and HBsAg-negative resolved infections: Current insights and future directions
    Lidawani Lambuk, Aina Akmal Mohd Noor, Fatmawati Lambuk, Tuan Noorkorina Tuan Kub, Muhammad Zulfiqah Sadikan, Norhayati Yusop, Rohimah Mohamud, Nik Haszroel Hysham Nik Hashim
    American Journal of the Medical Sciences, 2026
  • Understanding the link between lipid and ocular disorders for effective therapy
    Muhammad Zulfiqah Sadikan, Haryati Ahmad Hairi, Lidawani Lambuk
    Archives of Medical Science, 2026
    Cholesterol is an essential lipid for cellular integrity and metabolic homeostasis; however, dysregulated cholesterol metabolism is increasingly recognized as a key contributor to multiple ocular diseases. Beyond its established role in cardiovascular pathology, emerging evidence implicates altered lipoprotein balance, impaired cholesterol transport, and lipid-driven inflammation in the pathogenesis of age-related macular degeneration, retinal vascular diseases, cataracts, and glaucoma. This review integrates current knowledge on cholesterol synthesis, transport, and regulation with ocular-specific mechanisms, emphasizing the differential roles of low-density lipoprotein, high-density lipoprotein, and triglyceride-rich lipoproteins. Key molecular pathways, including the mevalonate-SREBP axis, ABCA1/ABCG1-mediated reverse cholesterol transport, VEGF-driven angiogenesis, oxidative stress signaling, and inflammatory cascades, are critically discussed. Clinical and translational implications are highlighted, particularly the potential ocular benefits of lipid-modulating therapies such as statins, fenofibrate, and antioxidant supplementation. Understanding cholesterol as a modifiable determinant of ocular health may enable integrated preventive strategies and guide future therapeutic innovation in vision-threatening diseases.
  • Nutraceuticals of Phoenix dactylifera L.: Physicochemistry, Nutritional Value and Therapeutic Potential
    Mohd Nizam Lani, Muhammad Fazel, Muhamad Razin Razali, Mohd Rajak, Abiramy Krishnan, Arashidatul Ismail, Mohd Mohd Lazaldin, Lidawani Lambuk, Rohimah Mohamud, Muhamad Yahaya, Izuddin Abu
    Drug Design Development and Therapy, 2026
    Abstract: Phoenix dactylifera L. (date palm) is a widely cultivated fruit tree valued for its nutritional richness and diverse bioactive profile. This review aimed to critically synthesize current evidence of physicochemical characteristics, nutrient composition, and pharmacological potential of date palm fruits, seeds, and leaves. Relevant literature was retrieved from PubMed, Scopus, ScienceDirect, and Google Scholar, with emphasis on extraction methodologies, nutritional attributes, phytochemical constituents, therapeutics properties, and translational relevance. Date palm products are rich in carbohydrates, dietary fiber, essential minerals, and phenolic and flavonoid compounds, such as gallic acid, catechin, quercetin, and ferulic acid, which underpin their antioxidant and anti-inflammatory properties. Experimental studies further suggest potential antimicrobial, antihyperlipidemic, antidiabetic, anticancer, anti-arthritic, neuroprotective, hepatoprotective, and gastroprotective effects. Notably, date seeds, often discarded as agricultural by-products, also exhibit substantial polyphenol content and antioxidant capacity, supporting their potential value in nutraceutical applications. However, the majority of reported biological effects are derived from in vitro and in vivo models, with limited and heterogeneous clinical evidence. Although accumulating preclinical findings highlight the functional and therapeutic promise of P. dactylifera L. important gaps remain regarding extract standardization, bioavailability, dose-response relationships, safety profiling, and clinical efficacy. Addressing these challenges is essential to facilitate evidence-based development of sustainable date palm-derived functional foods, dietary supplements, and potential pharmaceutical applications. Keywords: Phoenix dactylifera L., date palm, nutraceutical, therapeutic potential, bioactive compounds
  • Molecular Mechanisms of Vitamin E in Ocular Neurodegenerative Disorders: An Update on the Emerging Evidence and Therapeutic Implications
    Muhammad Zulfiqah Sadikan, Lidawani Lambuk, Nurhidayah Reshidan, Haryati Ahmad Hairi, Afiqq Aiman Abd Ghapor, Rohimah Mohamud, Nurul Alimah Abdul Nasir
    Journal of Ocular Pharmacology and Therapeutics, 2025
    Vitamin E is renowned for its potent antioxidant properties, crucial for shielding cells against oxidative stress and damage. Deficiency in this vitamin can lead to various health issues, including neurodegenerative diseases, due to its pivotal role in preserving cell membrane integrity and combating cellular oxidative damage. While its importance for overall health, including neurodegeneration, is acknowledged, the specific correlation between vitamin E deficiency and distinct ocular neurodegenerative disorders need to be further explored. This review delves into the molecular mechanisms of vitamin E in ocular neurodegenerative disorders; diabetic retinopathy, age-related macular degeneration, glaucoma, and cataracts, and emphasising the therapeutic implications drawn from existing evidence. Relationship between vitamin E and ocular neurodegenerative disorders is widely researched on, with its primary protective mechanisms attributed to its antioxidant and anti-inflammatory properties. However, studies on the supplementation of vitamin E among human subjects present mixed results, suggesting its complexities and variability depending on factors such as the specific disorder, disease stage, genetic differences, and form of vitamin E utilized. In conclusion, while vitamin E holds promise in mitigating ocular neurodegeneration through its antioxidant and anti-inflammatory properties, its supplementation's efficacy remains nuanced and context dependent. More research works are essential to elucidate its precise role and therapeutic potential in combating various ocular neurodegenerative disorders.
  • Liposomal topical drug administration surpasses alternative methods in glaucoma therapeutics: a novel paradigm for enhanced treatment
    Nor Asyikin Nordin, Muhammad Zulfiqah Sadikan, Lidawani Lambuk, Sabarisah Hashim, Syahira Airuddin, Nur-Azida Mohd Nasir, Rohimah Mohamud, Jamal Ibrahim, Ramlah Kadir
    Journal of Pharmacy and Pharmacology, 2025
    Objectives Glaucoma is a leading cause of permanent blindness. Despite therapeutic advancements, glaucoma management remains challenging due to limitations of conventional drug delivery, primarily topical eye drops, resulting in suboptimal outcomes and a global surge in cases. To address these issues, liposomal drug delivery has emerged as a promising approach. Key findings This review explores the potential of liposomal-based medications, with a particular focus on topical administration as a superior alternative to enhance therapeutic efficacy and improve patient compliance compared to existing treatments. This writing delves into the therapeutic prospects of liposomal formulations across different administration routes, as evidenced by ongoing clinical trials. Additionally, critical aspects of liposomal production and market strategies are discussed herein. Summary By overcoming ocular barriers and optimizing drug delivery, liposomal topical administration holds the key to significantly improving glaucoma treatment outcomes.
  • Age-Related Macular Degeneration Pathophysiology and Therapeutic Potential of Tocotrienols: An Update
    Muhammad Zulfiqah Sadikan, Lidawani Lambuk, Nur Hidayah Reshidan, Nurliyana Ain Abdul Ghani, Azral Ismawy Ahmad, Mohd Saleh Ahmad Kamal, Mohd Aizuddin Mohd Lazaldin, Haryati Ahmad Hairi, Rohimah Mohamud, Nurul Alimah Abdul Nasir
    Journal of Ocular Pharmacology and Therapeutics, 2025
    Age-related macular degeneration (AMD) poses a significant threat to visual health among the elderly, necessitating urgent preventive measures as the global population ages. Extensive research has implicated oxidative stress (OS)-induced retinal damage as a primary contributor to AMD pathogenesis, prompting investigations into potential therapeutic interventions. Among the various nutrients studied for their potential in AMD risk reduction, antioxidants have shown promise, with initial findings from the Age-Related Eye Disease Study suggesting a correlation between antioxidant supplementation and decreased AMD progression. This article explores the scientific foundation supporting the therapeutic efficacy of tocotrienol-rich fraction (TRF) as a viable candidate for slowing AMD progression, based on interventional studies. AMD is characterized by OS, inflammation, dysregulated lipid metabolism, and angiogenesis, all of which TRF purportedly addresses through its potent anti-inflammatory, lipid-lowering, antiangiogenic, and antioxidant properties. The review underscores TRF's promising attributes, aiming to deepen understanding of AMD pathogenesis and advocate for TRF-based pharmacological interventions to enhance therapeutic outcomes. Given the pressing need for effective AMD treatments, TRF represents a promising avenue for intervention, offering hope for improved vision outcomes and enhanced quality of life for individuals affected by this debilitating condition.
  • Molecular Impact of Magnesium-Mediated Immune Regulation in Diseases
    Muhammad Zulfiqah Sadikan, Lidawani Lambuk, Haryati Ahmad Hairi, Rohimah Mohamud
    Scientifica, 2025
    Magnesium (Mg) is a crucial mineral that is required for maintaining many of the physiological processes, including immune regulation. The immune system is a protective strategy against pathogenic infection, allergic reaction and tumour development. Dysregulation of immune functions results in different pathological conditions, including autoimmune disease, allergic diseases and infectious diseases. Mg plays a role in the modulation of immune responses through the regulation of the activation, proliferation and differentiation of immune cells. Moreover, research has shown that Mg participates in the treatment and prevention of different diseases, so it may serve as a therapeutic drug. Mg immunoregulatory activity and its applications in prevention and treatment of immune‐related disorders are discussed herein. Immunosuppression, reduced phagocytosis and suppressed natural killer cell function were associated with low concentrations of Mg, and these are critical for protection against viruses. Mg further affects inflammatory cytokine release and modulation of NF‐κB, a key immune signalling cascade. Evidence corroborates that supplementation with Mg might alleviate symptoms of immune diseases like SLE, bronchial asthma, inflammatory bowel disease and microbial infection. However, it is critical to conduct trials for establishing optimum dosing paradigms as well as the long‐term impact of Mg supplementation in the frame of immune disease.
  • Towards understanding the role of nanomedicine in targeting TNFR2 in rheumatoid arthritis
    Fatmawati Lambuk, Nor Asyikin Nordin, Ali Mussa, Lidawani Lambuk, Suhana Ahmad, Rosline Hassan, Ramlah Kadir, Rohimah Mohamud, Nurul Khaiza Yahya
    Immunology, 2024
  • Diabetic retinopathy: a comprehensive update on in vivo, in vitro and ex vivo experimental models
    Muhammad Zulfiqah Sadikan, Nurul Alimah Abdul Nasir, Lidawani Lambuk, Rohimah Mohamud, Nur Hidayah Reshidan, Evon Low, Saiful Anuar Singar, Awis Sukarni Mohmad Sabere, Igor Iezhitsa, Renu Agarwal
    BMC Ophthalmology, 2023
  • Progress in biomedical applications using sustainable nanoparticles
    Lidawani Lambuk, Suhana Ahmad, Siti Khatijah Abdul Razak, Ros Akmal Mohd Idris, Rohimah Mohamud
    Sustainable Material for Biomedical Engineering Application, 2023
  • The effect of palm oil-derived tocotrienol-rich fraction in preserving normal retinal vascular diameter in streptozotocin-induced diabetic rats
    Nurliyana Ain Abdul Ghani, Nurul Alimah Abdul Nasir, Lidawani Lambuk, Muhammad Zulfiqah Sadikan, Renu Agarwal, Norlina Ramli
    Graefe S Archive for Clinical and Experimental Ophthalmology, 2023
  • Growth factors and their receptors: multitasking functionality in health and disease
    Mohd Aizuddin Mohd Lazaldin, Lidawani Lambuk, Suhana Ahmad, Rohimah Mohamud
    Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders, 2023
  • Efficacy and Safety of Nab-Paclitaxel in Metastatic Gastric Cancer: A Meta-Analysis
    Suhana Ahmad, Lidawani Lambuk, Naveed Ahmed, Ali Mussa, Vincent Tee, Ros Akmal Mohd Idris, Nur Fazimah Sahran, Yean Yean Chan, Rosline Hassan, Yeong Yeh Lee, Rohimah Mohamud
    Nanomedicine, 2023
  • Nanoparticles for the treatment of glaucoma-associated neuroinflammation
    Lidawani Lambuk, Nurfatihah Azlyna Ahmad Suhaimi, Muhammad Zulfiqah Sadikan, Azliana Jusnida Ahmad Jafri, Suhana Ahmad, Nurul Alimah Abdul Nasir, Vuk Uskoković, Ramlah Kadir, Rohimah Mohamud
    Eye and Vision, 2022
  • Brain-Derived Neurotrophic Factor-Mediated Neuroprotection in Glaucoma: A Review of Current State of the Art
    Lidawani Lambuk, Mohd Aizuddin Mohd Lazaldin, Suhana Ahmad, Igor Iezhitsa, Renu Agarwal, Vuk Uskoković, Rohimah Mohamud
    Frontiers in Pharmacology, 2022
  • Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma
    Lidawani Lambuk, Suhana Ahmad, Muhammad Zulfiqah Sadikan, Nor Asyikin Nordin, Ramlah Kadir, Nurul Alimah Abdul Nasir, Xin Chen, Jennifer Boer, Magdalena Plebanski, Rohimah Mohamud
    Frontiers in Immunology, 2022
  • Applications of Alginate-Based Nanomaterials in Enhancing the Therapeutic Effects of Bee Products
    Mohammad A. I. Al-Hatamleh, Walhan Alshaer, Ma’mon M. Hatmal, Lidawani Lambuk, Naveed Ahmed, Mohd Zulkifli Mustafa, Siew Chun Low, Juhana Jaafar, Khalid Ferji, Jean-Luc Six, Vuk Uskoković, Rohimah Mohamud
    Frontiers in Molecular Biosciences, 2022
  • The role of TNFR2+ Tregs in COVID-19: An overview and a potential therapeutic strategy
    Suhana Ahmad, Ma'mon M. Hatmal, Lidawani Lambuk, Mohammad A.I. Al-Hatamleh, Walhan Alshaer, Rohimah Mohamud
    Life Sciences, 2021
  • Magnesium acetyltaurate prevents retinal damage and visual impairment in rats through suppression of NMDA-induced upregulation of NF-κB, p53 and AP-1 (c-Jun/c-Fos)
    Igor Iezhitsa, Lidawani Lambuk, Renu Agarwal, Puneet Agarwal, Anna Peresypkina, Anna Pobeda, NafeezaMohd Ismail
    Neural Regeneration Research, 2021
  • ANTIAPOPTOTIC EFFECT OF TAURINE AGAINST NMDA-INDUCED RETINAL EXCITOTOXICITY IN RATS
    Lidawani Lambuk, Igor Iezhitsa, Renu Agarwal, Nor Salmah Bakar, Puneet Agarwal, Nafeeza Mohd Ismail
    Neurotoxicology, 2019
  • Dose-dependent effects of NMDA on retinal and optic nerve morphology in rats
    L. Lambuk, A. Jafri, I. Iezhitsa, R. Agarwal, N. S. Bakar, Puneet Agarwal, Aimy Abdullah, N. Ismail
    International Journal of Ophthalmology, 2019
  • Neuroprotective Effect of Magnesium Acetyltaurate Against NMDA-Induced Excitotoxicity in Rat Retina
    Lidawani Lambuk, Azliana Jusnida Ahmad Jafri, Natasha Najwa Nor Arfuzir, Igor Iezhitsa, Renu Agarwal, Khairul Nizam Bin Rozali, Puneet Agarwal, Nor Salmah Bakar, Methil Kannan Kutty, Ahmad Pauzi Md. Yusof, Anna Krasilnikova, Alexander Spasov, Alexander Ozerov, Nafeeza Mohd Ismail
    Neurotoxicity Research, 2017
  • Protective effect of magnesium acetyltaurate against NMDA-induced retinal damage involves restoration of minerals and trace elements homeostasis
    Azliana Jusnida Ahmad Jafri, Natasha Najwa Nor Arfuzir, Lidawani Lambuk, Igor Iezhitsa, Renu Agarwal, Puneet Agarwal, Norhafiza Razali, Anna Krasilnikova, Maria Kharitonova, Vasily Demidov, Evgeny Serebryansky, Anatoly Skalny, Alexander Spasov, Ahmad Pauzi Md. Yusof, Nafeeza Mohd Ismail
    Journal of Trace Elements in Medicine and Biology, 2017
  • Protective effect of magnesium acetyltaurate against endothelin-induced retinal and optic nerve injury
    N.N.N. Arfuzir, L. Lambuk, A.J.A. Jafri, R. Agarwal, I. Iezhitsa, S. Sidek, P. Agarwal, N.S. Bakar, M.K Kutty, A.P.Md. Yusof, A. Krasilnikova, A. Spasov, A. Ozerov, N. Mohd Ismail
    Neuroscience, 2016

RECENT SCHOLAR PUBLICATIONS

  • Nutraceuticals of Phoenix dactylifera L .: Physicochemistry, Nutritional Value and Therapeutic Potential
    MN Lani, MF Fazel, MR Razali, MAA Rajak, A Krishnan, AA Ismail, ...
    Drug Design, Development and Therapy, 583862 , 2026
    2026
  • Prevalence and risk factors of hepatitis B vaccine non-response in hemodialysis patients: a narrative review
    NA Nordin, MZ Sadikan, L Lambuk, F Lambuk, AAM Noor, R Mohamud, ...
    The Journal of Infection in Developing Countries 20 (04), 494-505 , 2026
    2026
  • Role of dendritic cells and B cells in the skin of imiquimod (IMQ)-induced psoriasis-like mouse model
    AAM Noor, L Lambuk, F Ahmad, M Azlan, NM Redzwan
    PeerJ 14, e20974 , 2026
    2026
  • Nanotherapeutic potential in glaucoma associated ocular cancers
    L Lambuk, MZ Sadikan, MA Mohd Lazaldin, F Lambuk, R Kadir, N Ismail, ...
    Discover Oncology , 2026
    2026
  • Understanding the link between lipid and ocular disorders for effective therapy
    MZ Sadikan, HA Hairi, L Lambuk
    Archives of Medical Science , 2026
    2026
  • Navigating the landscape of hepatitis B virus reactivation in HBsAg-positive and HBsAg-negative resolved infections: Current insights and future directions
    L Lambuk, AAM Noor, F Lambuk, TNT Kub, MZ Sadikan, N Yusop, ...
    The American Journal of the Medical Sciences , 2025
    2025
  • UNDERSTANDING THE LINK BETWEEN CHOLESTEROL AND OCULAR DISORDERS FOR EFFECTIVE THERAPY.
    MZ Sadikan, L Lambuk, HA Hairi, R Mohamud
    International E-Journal of Science, Medicine & Education 19 , 2025
    2025
  • Age-Related Macular Degeneration Pathophysiology and Therapeutic Potential of Tocotrienols: An Update
    MZ Sadikan, L Lambuk, NH Reshidan, NA Abdul Ghani, AI Ahmad, ...
    Journal of Ocular Pharmacology and Therapeutics 41 (3), 150-161 , 2025
    2025
    Citations: 3
  • Molecular mechanisms of vitamin E in ocular neurodegenerative disorders: an update on the emerging evidence and therapeutic implications
    MZ Sadikan, L Lambuk, N Reshidan, H Ahmad Hairi, AA Abd Ghapor, ...
    Journal of Ocular Pharmacology and Therapeutics 41 (3), 89-100 , 2025
    2025
    Citations: 6
  • Liposomal topical drug administration surpasses alternative methods in glaucoma therapeutics: a novel paradigm for enhanced treatment
    NA Nordin, MZ Sadikan, L Lambuk, S Hashim, S Airuddin, NA Mohd Nasir, ...
    Journal of Pharmacy and Pharmacology 77 (4), 475-491 , 2025
    2025
    Citations: 7
  • Molecular Impact of Magnesium‐Mediated Immune Regulation in Diseases
    MZ Sadikan, L Lambuk, HA Hairi, R Mohamud
    Scientifica 2025 (1), 4211238 , 2025
    2025
    Citations: 5
  • Towards understanding the role of nanomedicine in targeting TNFR2 in rheumatoid arthritis
    F Lambuk, NA Nordin, A Mussa, L Lambuk, S Ahmad, R Hassan, R Kadir, ...
    Immunology 173 (4), 622-633 , 2024
    2024
    Citations: 2
  • Diabetic retinopathy: a comprehensive update on in vivo, in vitro and ex vivo experimental models
    MZ Sadikan, NA Abdul Nasir, L Lambuk, R Mohamud, NH Reshidan, ...
    BMC ophthalmology 23 (1), 421 , 2023
    2023
    Citations: 38
  • Efficacy and safety of nab-paclitaxel in metastatic gastric cancer: a meta-analysis
    S Ahmad, L Lambuk, N Ahmed, A Mussa, V Tee, RA Mohd Idris, ...
    Nanomedicine 18 (24), 1733-1744 , 2023
    2023
    Citations: 14
  • Progress in biomedical applications using sustainable nanoparticles
    L Lambuk, S Ahmad, SK Abdul Razak, RA Mohd Idris, R Mohamud
    Sustainable Material for Biomedical Engineering Application, 207-238 , 2023
    2023
    Citations: 3
  • The effect of palm oil-derived tocotrienol-rich fraction in preserving normal retinal vascular diameter in streptozotocin-induced diabetic rats
    NA Abdul Ghani, NA Abdul Nasir, L Lambuk, MZ Sadikan, R Agarwal, ...
    Graefe's Archive for Clinical and Experimental Ophthalmology 261 (6), 1587-1596 , 2023
    2023
    Citations: 13
  • Growth factors and their receptors: multitasking functionality in health and disease
    MAM Lazaldin, L Lambuk, S Ahmad, R Mohamud
    Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders … , 2023
    2023
    Citations: 1
  • Nanoparticles for the treatment of glaucoma-associated neuroinflammation
    L Lambuk, NAA Suhaimi, MZ Sadikan, AJA Jafri, S Ahmad, NAA Nasir, ...
    Eye and Vision 9 (1), 26 , 2022
    2022
    Citations: 31
  • Brain-derived neurotrophic factor-mediated neuroprotection in glaucoma: a review of current state of the art
    L Lambuk, MA Mohd Lazaldin, S Ahmad, I Iezhitsa, R Agarwal, ...
    Frontiers in Pharmacology 13, 875662 , 2022
    2022
    Citations: 77
  • Targeting differential roles of tumor necrosis factor receptors as a therapeutic strategy for glaucoma
    L Lambuk, S Ahmad, MZ Sadikan, NA Nordin, R Kadir, NAA Nasir, ...
    Frontiers in Immunology 13, 857812 , 2022
    2022
    Citations: 17

MOST CITED SCHOLAR PUBLICATIONS

  • Neuroprotective effect of magnesium acetyltaurate against NMDA-induced excitotoxicity in rat retina
    L Lambuk, AJA Jafri, NNN Arfuzir, I Iezhitsa, R Agarwal, KNB Rozali, ...
    Neurotoxicity Research 31 (1), 31-45 , 2017
    2017
    Citations: 87
  • Brain-derived neurotrophic factor-mediated neuroprotection in glaucoma: a review of current state of the art
    L Lambuk, MA Mohd Lazaldin, S Ahmad, I Iezhitsa, R Agarwal, ...
    Frontiers in Pharmacology 13, 875662 , 2022
    2022
    Citations: 77
  • Applications of alginate-based nanomaterials in enhancing the therapeutic effects of bee products
    MAI Al-Hatamleh, W Alshaer, MM Hatmal, L Lambuk, N Ahmed, ...
    Frontiers in Molecular Biosciences 9, 865833 , 2022
    2022
    Citations: 60
  • Protective effect of magnesium acetyltaurate against endothelin-induced retinal and optic nerve injury
    NNN Arfuzir, L Lambuk, AJA Jafri, R Agarwal, I Iezhitsa, S Sidek, ...
    Neuroscience 325, 153-164 , 2016
    2016
    Citations: 45
  • Dose-dependent effects of NMDA on retinal and optic nerve morphology in rats
    L Lambuk, AJA Jafri, I Iezhitsa, R Agarwal, NS Bakar, P Agarwal, ...
    International journal of ophthalmology 12 (5), 746 , 2019
    2019
    Citations: 42
  • Antiapoptotic effect of taurine against NMDA-induced retinal excitotoxicity in rats
    L Lambuk, I Iezhitsa, R Agarwal, NS Bakar, P Agarwal, NM Ismail
    Neurotoxicology 70, 62-71 , 2019
    2019
    Citations: 40
  • Diabetic retinopathy: a comprehensive update on in vivo, in vitro and ex vivo experimental models
    MZ Sadikan, NA Abdul Nasir, L Lambuk, R Mohamud, NH Reshidan, ...
    BMC ophthalmology 23 (1), 421 , 2023
    2023
    Citations: 38
  • Magnesium acetyltaurate prevents retinal damage and visual impairment in rats through suppression of NMDA-induced upregulation of NF-κB, p53 and AP-1 (c-Jun/c-Fos)
    L Lambuk, I Iezhitsa, R Agarwal, P Agarwal, A Peresypkina, A Pobeda, ...
    Neural Regeneration Research 16 (11), 2330-2344 , 2021
    2021
    Citations: 38
  • Protective effect of magnesium acetyltaurate against NMDA-induced retinal damage involves restoration of minerals and trace elements homeostasis
    AJA Jafri, NNN Arfuzir, L Lambuk, I Iezhitsa, R Agarwal, P Agarwal, ...
    Journal of Trace Elements in Medicine and Biology 39, 147-154 , 2017
    2017
    Citations: 36
  • Nanoparticles for the treatment of glaucoma-associated neuroinflammation
    L Lambuk, NAA Suhaimi, MZ Sadikan, AJA Jafri, S Ahmad, NAA Nasir, ...
    Eye and Vision 9 (1), 26 , 2022
    2022
    Citations: 31
  • Targeting differential roles of tumor necrosis factor receptors as a therapeutic strategy for glaucoma
    L Lambuk, S Ahmad, MZ Sadikan, NA Nordin, R Kadir, NAA Nasir, ...
    Frontiers in Immunology 13, 857812 , 2022
    2022
    Citations: 17
  • The role of TNFR2+ Tregs in COVID-19: an overview and a potential therapeutic strategy
    S Ahmad, MH Ma'mon, L Lambuk, MAI Al-Hatamleh, W Alshaer, ...
    Life sciences 286, 120063 , 2021
    2021
    Citations: 17
  • Efficacy and safety of nab-paclitaxel in metastatic gastric cancer: a meta-analysis
    S Ahmad, L Lambuk, N Ahmed, A Mussa, V Tee, RA Mohd Idris, ...
    Nanomedicine 18 (24), 1733-1744 , 2023
    2023
    Citations: 14
  • The effect of palm oil-derived tocotrienol-rich fraction in preserving normal retinal vascular diameter in streptozotocin-induced diabetic rats
    NA Abdul Ghani, NA Abdul Nasir, L Lambuk, MZ Sadikan, R Agarwal, ...
    Graefe's Archive for Clinical and Experimental Ophthalmology 261 (6), 1587-1596 , 2023
    2023
    Citations: 13
  • The use of Fiji image J as an image analysis tool for measuring retinal vessel diameter in rodent model of diabetic retinopathy
    MZ Sadikan, NAA Nasir, NAA Ghani, L Lambuk, IN Iezhitsa, R Agarwal
    Asian Journal of Medicine and Biomedicine 5 (1), 61-66 , 2021
    2021
    Citations: 13
  • Liposomal topical drug administration surpasses alternative methods in glaucoma therapeutics: a novel paradigm for enhanced treatment
    NA Nordin, MZ Sadikan, L Lambuk, S Hashim, S Airuddin, NA Mohd Nasir, ...
    Journal of Pharmacy and Pharmacology 77 (4), 475-491 , 2025
    2025
    Citations: 7
  • Molecular mechanisms of vitamin E in ocular neurodegenerative disorders: an update on the emerging evidence and therapeutic implications
    MZ Sadikan, L Lambuk, N Reshidan, H Ahmad Hairi, AA Abd Ghapor, ...
    Journal of Ocular Pharmacology and Therapeutics 41 (3), 89-100 , 2025
    2025
    Citations: 6
  • Applications of alginate-based nanomaterials in enhancing the therapeutic effects of bee products. Front Mol Biosci
    M Al-Hatamleh, W Alshaer, M Hatmal, L Lambuk, N Ahmed, MZ Mustafa, ...
    2022
    Citations: 6
  • Molecular Impact of Magnesium‐Mediated Immune Regulation in Diseases
    MZ Sadikan, L Lambuk, HA Hairi, R Mohamud
    Scientifica 2025 (1), 4211238 , 2025
    2025
    Citations: 5
  • Age-Related Macular Degeneration Pathophysiology and Therapeutic Potential of Tocotrienols: An Update
    MZ Sadikan, L Lambuk, NH Reshidan, NA Abdul Ghani, AI Ahmad, ...
    Journal of Ocular Pharmacology and Therapeutics 41 (3), 150-161 , 2025
    2025
    Citations: 3