@klescoph.org
Associate Professor Department of Pharmacognosy
KLE COLLEGE OF PHARMACY
M.Pharm in Pharmacognosy
Screening of herbal drugs for their potential pharmacological and therapeutical applications
Scopus Publications
GulabS Shinde, RavindraV Karadi, AjayS Khedkar, PravinJ Dere, YuvarajD Mandavkar, and PallaviR Khalure
BRNSS Publication Hub
R.V. Karadi, M.B. Palkar, E.N. Gaviraj, N.B. Gadge, V.S. Mannur, and K.R. Alagawadi
Informa UK Limited
In spite of tremendous advances in the field of medicine, there is no truly satisfactory drug for the treatment of renal calculi. In the present study, the efficacy of the root bark of Moringa oleifera Lam. (Moringaceae) as an antiurolithiatic agent was investigated using an experimentally induced urolithiatic rat model. Hyperoxaluria was induced in rats using 0.75% ethylene glycol in water. Aqueous (AqE) (200 mg kg− 1 body weight) and alcoholic extracts (AlcE) (200 mg kg− 1 body weight) of the root bark of M. oleifera were given orally in curative and preventive regimens over a period of 28 days. Both the extracts significantly (P < 0.001) lowered the urinary excretion and kidney retention levels of oxalate, calcium and phosphate. Moreover, elevated serum levels of urea nitrogen, creatinine and uric acid were significantly (P < 0.001) reduced by the extracts. The results were comparable with the standard drug, cystone (750 mg kg− 1 body weight). The reduction of stone forming constituents in urine and their decreased kidney retention reduces the solubility product of crystallizing salts such as calcium oxalate and calcium phosphate, which could contribute to the antiurolithiatic property of root bark of M. oleifera.
Ravindra V. Karadi, Navneet B. Gadge, K.R. Alagawadi, and Rudraprabhu V. Savadi
Elsevier BV
VI Hukkeri, CV Nagathan, RV Karadi, and BS Patil
OMICS Publishing Group
Qualitative chemical tests confirmed the presence of phytosterols, glycosides, tannins, and amino acids in the various leaf extracts of Moringa oleifera Lam., whereas its seed extracts showed the presence of phytosterols, glycosides, phenolic compounds, carbohydrates and amino acids. The ethanolic and ethyl acetate extracts of seeds showed significant antipyretic activity in rats, whereas ethyl acetate extract of dried leaves showed significant wound healing activity (10% extracts in the form of ointment) on excision, incision and dead space (granuloma) wound models in rats.