zeinab karimi

@medilam.ac.ir

Tuberculosis and Lung Diseases Research Center, Ilam University of Medical Sciences
Ilam University of Medical Sciences

zeinab karimi


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https://researchid.co/zeinab.karimi05

EDUCATION

Ph.D. in Medical Virology

RESEARCH, TEACHING, or OTHER INTERESTS

Virology, Immunology, Infectious Diseases, Immunology and Microbiology
7

Scopus Publications

52

Scholar Citations

3

Scholar h-index

3

Scholar i10-index

Scopus Publications

  • Economic evaluation of direct oral anticoagulants (DOACs) for venous thromboembolism with different etiologies: a systematic review
    Fereshte Karimi, Soheila Rajaie, Samad Azari, Mohammad Saeid Abbaszadeh, Zeinab Karimi
    Health Economics Review, 2026
    BACKGROUND: Venous thromboembolism (VTE) imposes significant clinical and economic burdens. While direct oral anticoagulants (DOACs) offer favorable efficacy and safety, their cost-effectiveness across diverse VTE etiologies remains incompletely synthesized. OBJECTIVE: To systematically evaluate the cost-effectiveness of DOACs versus comparators for VTE management stratified by etiology. METHODS: A PRISMA-compliant systematic search was conducted in MEDLINE, Web of Science, Scopus, and NHS EED (2020–2025). Economic evaluations reporting cost-effectiveness or cost-utility outcomes were included. Study quality was assessed using the Drummond checklist. RESULTS: Twenty studies were included (9 CAT, 3 post-surgical, 6 hospitalized VTE, 2 COVID-19). DOACs were cost-effective or dominant in 18/20 studies. For cancer-associated thrombosis (CAT), DOACs dominated LMWHs and were cost-effective versus placebo (ICERs: ,794–1,947/QALY). DOACs were also dominant for post-surgical prophylaxis and in general hospitalized VTE (ICERs: -,862/QALY to 25.68/QALY), while rivaroxaban was cost-effective for post-COVID-19 prophylaxis (ICER: ,386/QALY). CONCLUSION: DOACs, particularly apixaban and rivaroxaban, are an economically dominant strategy for VTE across most etiologies. Their adoption as a first-line therapy can improve patient outcomes while significantly reducing healthcare costs.
  • Respiratory Viral Coinfections: Impacts on Virus Replication and Host Immune Response
    Fariba Shokri, Abas Gheisoori, Abas Maleki, Shima Izadi Dakhrabadi, Azra Kenarkoohi, Shahab Falahi, Ali Nazari, Jalil Feizi, Zeinab Karimi
    Turkish Journal of Immunology, 2026
  • Acceptance and the willingness to pay for human papilloma virus (HPV) vaccine: A systematic review
    Soheila Rajaie, Sara Emamgholipour, Samad Azari, Zeinab Karimi, Fereshte Karimi
    Human Vaccines and Immunotherapeutics, 2026
    Human papillomavirus (HPV) is a major global health concern due to its link to cervical and other cancers. Although HPV vaccination is highly effective, acceptance and willingness to pay (WTP) differ widely across populations. This review summarizes global evidence from 2015-2025. A systematic search of PubMed, Scopus, CENTRAL, Web of Science, and Google Scholar was conducted in 2025 following PRISMA guidelines. Studies reporting data on knowledge, acceptance, attitudes, and WTP across any population were included. Quality assessment used ISPOR checklists, and data were synthesized in Excel 2019. Thirty-five studies met inclusion criteria, with China and Nigeria contributing most. WTP ranged from 52.68% in lower-middle-income countries to 65.38% in low-income countries. Mean WTP was highest in upper-middle-income settings. Knowledge, positive attitudes, socioeconomic status, and trust increased WTP, while cost remained the primary barrier. Improving affordability, awareness, and policy support is essential to enhance global HPV.
  • Metabolomics Study on Vitamin D Effect in Immune Cells Metabolism Against Influenza Virus
    Zeinab Karimi, Talat Mokhtari Azad, Afsaneh Arefi Oskouie, Sayed Mahdi Marashi, Fatemeh Ajaminejad, Farhad Rezaei
    Indian Journal of Clinical Biochemistry, 2025
  • SARS-CoV-2 in brief: From virus to prevention
    Hassan Karami, Zeinab Karimi, Negin Karami
    Osong Public Health and Research Perspectives, 2022
    The recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a highly transmissible virus with a likely animal origin, has posed major and unprecedented challenges to millions of lives across the affected nations of the world. This outbreak first occurred in China, and despite massive regional and global attempts shortly thereafter, it spread to other countries and caused millions of deaths worldwide. This review presents key information about the characteristics of SARS-CoV-2 and its associated disease (namely, coronavirus disease 2019) and briefly discusses the origin of the virus. Herein, we also briefly summarize the strategies used against viral spread and transmission.
  • The effect of influenza virus on the metabolism of peripheral blood mononuclear cells with a metabolomics approach
    Zeinab Karimi, Afsaneh A. Oskouie, Farhad Rezaei, Fatemeh Ajaminejad, Sayed M. Marashi, Talat‐Mokhtari Azad
    Journal of Medical Virology, 2022
    Respiratory viruses have led to many deaths and hospitalizations per year in the world. The influenza virus is one of the most important respiratory viruses. Recently, metabolic studies in viral infections have been widely studied by scientists. Metabolomics states the metabolites present in a living organism under certain conditions. In this study, peripheral blood mononuclear cells were spinoculated using a virus produced by the Madin‐Darby canine kidney cell culture system, and cells were harvested following spinoculation by the influenza virus. Isolation of peripheral blood mononuclear cells was performed by Ficoll‐Paque density gradient centrifugation. Metabolites were extracted using organic and water approaches. Metabolic profiling was performed by a nontargeted technique using liquid chromatography with tandem mass spectrometry. Multivariate analysis methods were used to determine the main variables. the metabolic pathways involved were determined using databases. Results of the present study showed changes in biosynthesis pathways such as lipids, polyamines, catecholamines, and vitamins. Findings also showed that it is possible to explain the process of inflammation caused by the influenza virus by studying the metabolism of immune cells.
  • Proposed Pathway Linking Respiratory Infections with Depression
    Zeinab Karimi, Maryam Chenari, Farhad Rezaie, Shima Karimi, Najmeh Parhizgari, Talat Mokhtari-Azad
    Clinical Psychopharmacology and Neuroscience, 2022
    Depression is one of the most important causes of disability and loss of useful life of people around the world. Acute respiratory infection caused a large number of severe illnesses and deaths of the world and most of these due to viral infections, which is estimated more than 80% of respiratory infections. Detection of viruses by immune pathogen recognition receptors activates the intracellular signaling cascade and eventually cause produces interferons. Inflammatory process begins with secretion of interferons and the expression of interferon-stimulated genes. One of the most important of these genes is indoleamine-pyrrole 2,3-dioxygenase (IDO), which plays a major role in tryptophan catabolism. IDO is an intracellular monomeric enzyme that is also responsible for breaking down and consuming tryptophan in the Kynurenine pathway. Increased inflammation has been linked to decrease tryptophan concentrations and increase kynurenine levels. We tried to explain the role of inflammation by viral respiratory infections in causing depression.

RECENT SCHOLAR PUBLICATIONS

  • Acceptance and the willingness to pay for human papilloma virus (HPV) vaccine: A systematic review
    S Rajaie, S Emamgholipour, S Azari, Z Karimi, F Karimi
    Human Vaccines & Immunotherapeutics 22 (1), 2609345 , 2026
    2026
  • Respiratory Viral Coinfections: Impacts on Virus Replication and Host Immune Response
    F Shokri, A Gheisoori, A Maleki, SI Dakhrabadi, A Kenarkoohi, S Falahi, ...
    Turk J Immunol 14 (1), 6-14 , 2026
    2026
    Citations: 1
  • Economic evaluation of direct oral anticoagulants (DOACs) for venous thromboembolism with different etiologies: a systematic review
    F Karimi, S Rajaie, S Azari, MS Abbaszadeh, Z Karimi
    Health Economics Review , 2026
    2026
  • Mass Gatherings Health Management in Arbaeen-Iran: A Successful Model for Infectious Disease Control in Global Mass Gatherings
    F Hemmati, A Rashidi, J Sadeghifar, A Kenarkoohi, Z Karimi, S Falahi
    2026
    Citations: 1
  • Metabolomics Study on Vitamin D Effect in Immune Cells Metabolism Against Influenza Virus
    Z Karimi, T Mokhtari Azad, A Arefi Oskouie, SM Marashi, F Ajaminejad, ...
    Indian Journal of Clinical Biochemistry, 1-11 , 2025
    2025
  • SARS-CoV-2 in brief: from virus to prevention
    H Karami, Z Karimi, N Karami
    Osong Public Health and Research Perspectives 13 (6), 394 , 2022
    2022
    Citations: 16
  • The effect of influenza virus on the metabolism of peripheral blood mononuclear cells with a metabolomics approach
    Z Karimi, AA Oskouie, F Rezaei, F Ajaminejad, SM Marashi, TM Azad
    Journal of Medical Virology 94 (9), 4383-4392 , 2022
    2022
    Citations: 10
  • Proposed pathway linking respiratory infections with depression
    Z Karimi, M Chenari, F Rezaie, S Karimi, N Parhizgari, T Mokhtari-Azad
    Clinical Psychopharmacology and Neuroscience 20 (2), 199 , 2022
    2022
    Citations: 24
  • SARS-CoV-2 as emerging disease: preventive instructions and review of literature
    M Chenari, Z Karimi, MHK Niya
    International Journal of Tropical Medicine, 103-108 , 2020
    2020

MOST CITED SCHOLAR PUBLICATIONS

  • Proposed pathway linking respiratory infections with depression
    Z Karimi, M Chenari, F Rezaie, S Karimi, N Parhizgari, T Mokhtari-Azad
    Clinical Psychopharmacology and Neuroscience 20 (2), 199 , 2022
    2022
    Citations: 24
  • SARS-CoV-2 in brief: from virus to prevention
    H Karami, Z Karimi, N Karami
    Osong Public Health and Research Perspectives 13 (6), 394 , 2022
    2022
    Citations: 16
  • The effect of influenza virus on the metabolism of peripheral blood mononuclear cells with a metabolomics approach
    Z Karimi, AA Oskouie, F Rezaei, F Ajaminejad, SM Marashi, TM Azad
    Journal of Medical Virology 94 (9), 4383-4392 , 2022
    2022
    Citations: 10
  • Respiratory Viral Coinfections: Impacts on Virus Replication and Host Immune Response
    F Shokri, A Gheisoori, A Maleki, SI Dakhrabadi, A Kenarkoohi, S Falahi, ...
    Turk J Immunol 14 (1), 6-14 , 2026
    2026
    Citations: 1
  • Mass Gatherings Health Management in Arbaeen-Iran: A Successful Model for Infectious Disease Control in Global Mass Gatherings
    F Hemmati, A Rashidi, J Sadeghifar, A Kenarkoohi, Z Karimi, S Falahi
    2026
    Citations: 1
  • Acceptance and the willingness to pay for human papilloma virus (HPV) vaccine: A systematic review
    S Rajaie, S Emamgholipour, S Azari, Z Karimi, F Karimi
    Human Vaccines & Immunotherapeutics 22 (1), 2609345 , 2026
    2026
  • Economic evaluation of direct oral anticoagulants (DOACs) for venous thromboembolism with different etiologies: a systematic review
    F Karimi, S Rajaie, S Azari, MS Abbaszadeh, Z Karimi
    Health Economics Review , 2026
    2026
  • Metabolomics Study on Vitamin D Effect in Immune Cells Metabolism Against Influenza Virus
    Z Karimi, T Mokhtari Azad, A Arefi Oskouie, SM Marashi, F Ajaminejad, ...
    Indian Journal of Clinical Biochemistry, 1-11 , 2025
    2025
  • SARS-CoV-2 as emerging disease: preventive instructions and review of literature
    M Chenari, Z Karimi, MHK Niya
    International Journal of Tropical Medicine, 103-108 , 2020
    2020