Koteswara Rao Yerra

Scopus Publications

Cinnamaldehyde inhibits the NLRP3 inflammasome and inflammatory response by reducing oxidative stress in Neisseria gonorrhoeae-infected macrophages
Kuo-Feng Hua, Hsiao-Wen Chiu, Miao-Mei Chen, Wei-Ting Wong, Wen-Chiuan Tsai, et al.
Journal of Traditional and Complementary Medicine, 2026
Enhancing Antibiotic Effect by Photodynamic: The Case of Klebsiella pneumoniae
Koteswara Rao Yerra, Vanderlei S. Bagnato
Antibiotics, 2025
Background: The effect of antibiotics can be severely affected by external factors. Combining the oxidative impact of photodynamic therapy with antibiotics is largely unexplored, which may result in positive results with great impact on clinical applications. In particular, that can be relevant in the case of antibiotic resistance. Objectives: In this study, we examined the effects of aPDT using the photosensitizers (PSs), methylene blue (MB) or Photodithazine (PDZ), both alone and in combination with the antibiotics ciprofloxacin (CIP), gentamicin (GEN), and ceftriaxone (CEF), against the Gram-negative bacterium Klebsiella pneumoniae. Methods: A standard suspension of K. pneumoniae was subjected to PDT with varying doses of MB and PDZ solutions, using a 75 mW/cm2 LED emitting at 660 nm with an energy of 15 J/cm2. The MICs of CIP, GEN, and CEF were determined using the broth dilution method. We also tested the photosensitizers MB or PDZ as potentiating agents for synergistic combinations with antibiotics CIP, GEN, and CEF against K. pneumoniae. Results: The results showed that MB was more effective in inhibiting survival and killing K. pneumoniae compared to PDZ. The tested antibiotics CIP, GEN, and CEF suppressed bacterial growth (as shown by reduced MIC values) and effectively killed K. pneumoniae (reduced Log CFU/mL). While antibiotic treatment or aPDT alone showed a moderate effect (1 Log10 to 2 Log10 CFU reduction) on killing K. pneumoniae, the combination therapy significantly increased bacterial death, resulting in a ≥3 Log10 to 6 Log10 CFU reduction. Conclusions: Our study indicates that pre-treating bacteria with PDT makes them more susceptible to antibiotics and could serve as an alternative for treating local infections caused by resistant bacteria or even reduce the required antibiotic dosage. This work explores numerous possible combinations of PDT and antibiotics, emphasizing their interdependence in controlling infections and the unique properties each PS-antibiotic combination offers. Clinical application for the combination is a promising reality since both are individually already adopted in clinical use.
Combined Antibiotic and Photodynamic Therapies in Pseudomonas aeruginosa: From Synergy to Antagonism
Amanda C. Zangirolami, Koteswara Rao Yerra, Vladislav V. Yakovlev, Kate C. Blanco, Vanderlei S. Bagnato
Antibiotics, 2024
Background: Antibiotics remain the most effective option for combating infections. However, the situation has shifted from ideal to concerning, as bacterial resistance to antibiotics is increasing in both prevalence and strength. Objectives: This study explores the synergistic/antagonistic potential of combining antibiotic and photodynamic therapy (PDT) against Pseudomonas aeruginosa. Methods: We conducted in vitro experiments to observe the effect of the sequential application of antibiotics and photodynamic therapy with a time interval between them. The antibiotics used were ciprofloxacin, ceftriaxone, and gentamicin, and Photodithazine was employed as the photosensitizer, with the PDT performed at different light doses of 660 nm radiation. Results: The combined effect was highly dependent on the antibiotic. While for gentamicin, the combination of antibiotic and PDT treatment was always synergistic, for ciprofloxacin, it could be severely antagonistic. Each antibiotic exhibited a distinctive pattern of interaction with PDT. Gentamicin resulted in the largest enhancement in bactericidal activity combined with PDT, requiring lower antibiotic concentrations to achieve significant bacterial reduction. Ceftriaxone’s bactericidal action was less influenced by PDT intensity, maintaining a stable efficacy regardless of different PDT dosages. Conversely, the outcome of ciprofloxacin was highly dependent on the antibiotic concentration changing from synergic to antagonistic action. Conclusions: The findings advocate for the development of treatment protocols that combine antibiotics and PDT and necessitate the establishment of the criterion for the dosage and periodicity of administration of such combination protocols. The demonstrated results open the doors wide to new applications and opportunities to combat infectious diseases through the combined use of photodynamic therapy and antibiotics.
Exploring Candesartan, an angiotensin II receptor antagonist, as a novel inhibitor of NLRP3 inflammasome: alleviating inflammation in Neisseria gonorrhoeae infection
Wen-Yu Lin, Jin-Lian Tsui, Hsiao-Wen Chiu, Wei-Ting Wong, Chun‑Hsien Wu, et al.
BMC Infectious Diseases, 2024
The Biosynthetic Gene Cluster of Mushroom-Derived Antrocin Encodes Two Dual-Functional Haloacid Dehalogenase-like Terpene Cyclases
Tzu‐Ho Chen, Chien‐Ting Chen, Chi‐Fang Lee, Rou‐Jie Huang, Kuan‐Lin Chen, et al.
Angewandte Chemie International Edition, 2023
(−)‐Antrocin (1), produced by the medicinal mushroom Antrodia cinnamomea, is a potent antiproliferative compound. The biosynthetic gene cluster of 1 was identified, and the pathway was characterized by heterologous expression. We characterized a haloacid dehalogenase‐like terpene cyclase AncC that biosynthesizes the drimane‐type sesquiterpene (+)‐albicanol (2) from farnesyl pyrophosphate (FPP). Biochemical characterization of AncC, including kinetic studies and mutagenesis, demonstrated the functions of two domains: a terpene cyclase (TC) and a pyrophosphatase (PPase). The TC domain first cyclizes FPP to albicanyl pyrophosphate, and the PPase domain then removes the pyrophosphate to form 2. Intriguingly, AncA (94 % sequence identity to AncC), in the same gene cluster, converts FPP into (R)‐trans‐γ‐monocyclofarnesol instead of 2. Notably, Y283/F375 in the TC domain of AncA serve as a gatekeeper in controlling the formation of a cyclofarnesoid rather than a drimane‐type scaffold.
Antioxidant activities of underexplored Chinese medicinal plant parts and their effect against high glucose-induced modulation of fibronectin expression
B Sridharan, Y X Zhong, Y K Rao, Y M Tzeng, M J Lee
Iop Conference Series Earth and Environmental Science, 2021
Diabetes has been a long-standing disorder and its management has been challenging various medical and research experts for several decades because of its complex causative factors and pathophysiological processes leading to complications. Medicinal plants have been explored in several countries and traditional Chinese medicine is one of the well-recognized alternative treatment methods. In this study, we have chosen some of the underexplored plant parts of Chinese medicinal herbs and analyzed their antioxidant activity and ability to modulate the expression of fibronectin during high glucose conditions. Extraction of the plant materials with different solvent led to 17 extracts and among which, 3 extracts (2, 12 & 17) were observed to render more than 50 μg/ml vitamin C equivalents of DPPH free radical scavenging ability and 2 of them (2 & 17) showed more than 25 μg/ml of vitamin C equivalents of ferric ion reducing power. Based on the antioxidant activity and comparison of their total phenolic content, we used extracts 2 & 17 to check their effect on fibronectin expression in MES-13 cells under high sugar conditions. We observed that both extracts showed a significant reduction of fibronectin expression compared to untreated cells with high glucose levels. The expression was much lesser than the normal untreated, normal sugar supplemented cells and this was not observed in vitamin C supplemented cells. In conclusion, crude extracts containing a group of phenolic compounds have shown significant effects against fibronectin expression leading to reduced ECM deposition and tissue fibrosis. Further exploration might provide insights into the exact mechanism and checkpoints of the extract that can successfully reduce diabetes-induced renal complications.
Synthetic 4-Hydroxy Auxarconjugatin B, a Novel Autophagy Inducer, Attenuates Gouty Inflammation by Inhibiting the NLRP3 Inflammasome
Chih-Yu Hsieh, Lan-Hui Li, Yulin Lam, Zhanxiong Fang, Chin Heng Gan, et al.
Cells, 2020
Gouty arthritis results from the generation of uric acid crystals within the joints. These uric acid crystals activate the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome, which is involved in chronic inflammatory diseases, including gouty arthritis. This study identified the polyenylpyrrole derivative 4-hydroxy auxarconjugatin B (4-HAB), a novel autophagy inducer, which attenuated uric acid crystals-mediated activation of the NLRP3 inflammasome in vitro and in vivo. 4-HAB dose-dependently reduced the release of interleukin (IL)-1β, IL-18, active caspase-1 and apoptosis-associated speck-like protein (ASC) in uric acid crystals-activated macrophages. In a mechanistic study, 4-HAB was shown to inhibit uric acid crystals-induced mitochondrial damage, lysosomal rupture and ASC oligomerization. Additionally, 4-HAB inhibited the NLRP3 inflammasome through Sirt1-dependent autophagy induction. Furthermore, the anti-inflammatory properties of 4-HAB were confirmed in a mouse model of uric acid crystals-mediated peritonitis by the reduced levels of neutrophil influx, IL-1β, active caspase-1, IL-6 and MCP-1 in lavage fluids. In conclusion, 4-HAB attenuates gouty inflammation, in part by attenuating activation of the NLRP3 inflammasome through the Sirt1/autophagy induction pathway.
Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome
Hsiao-Wen Chiu, Lan-Hui Li, Chih-Yu Hsieh, Yerra Koteswara Rao, Fang-Hsin Chen, et al.
Scientific Reports, 2019
The NLRP3 inflammasome promotes the pathogenesis of metabolic, neurodegenerative and infectious diseases. Increasing evidences show that the NLRP3 inflammasome is a promising therapeutic target in inflammatory diseases. Glucosamine is widely used as a dietary supplement to promote the health of cartilage tissue and is expected to exert anti-inflammatory activity in joint inflammation, which is a nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome-associated complication. Here, we investigated whether GlcN inhibits the NLRP3 inflammasome and dissected the underlying molecular mechanisms. We found that GlcN suppressed the NLRP3 inflammasome in mouse and human macrophages. A mechanistic study revealed that GlcN inhibited the expression of NLRP3 and IL-1β precursor by reducing reactive oxygen species generation and NF-κB activation in lipopolysaccharide-activated macrophages. GlcN also suppressed mitochondrial reactive oxygen species generation and mitochondrial integrity loss in NLRP3-activated macrophages. Additionally, GlcN disrupted NLRP3 inflammasome assembly by inhibiting NLRP3 binding to PKR, NEK7 and ASC. Furthermore, oral administration of GlcN reduced peritoneal neutrophils influx and lavage fluids concentrations of IL-1β, IL-6 MCP-1 and TNF-α in uric acid crystal-injected mice. These results indicated that GlcN might be a novel dietary supplement for the amelioration of NLRP3 inflammasome-associated complications.
Mechanistic insight into the attenuation of gouty inflammation by Taiwanese green propolis via inhibition of the NLRP3 inflammasome
Chih‐Yu Hsieh, Lan‐Hui Li, Yerra Koteswara Rao, Tz‐Chuen Ju, Yu‐Shin Nai, et al.
Journal of Cellular Physiology, 2019
Dysregulation of NACHT, LRR, and PYD domains‐containing protein 3 (NLRP3) inflammasome is involved in many chronic inflammatory diseases, including gouty arthritis. Activation of the NLRP3 inflammasome requires priming and activation signals: the priming signal controls the expression of NLRP3 and interleukin (IL)‐1β precursor (proIL‐1β), while the activation signal leads to the assembly of the NLRP3 inflammasome and to caspase‐1 activation. Here, we reported the effects of the alcoholic extract of Taiwanese green propolis (TGP) on the NLRP3 inflammasome in vitro and in vivo. TGP inhibited proIL‐1β expression by reducing nuclear factor kappa B activation and reactive oxygen species (ROS) production in lipopolysaccharide‐activated macrophages. Additionally, TGP also suppressed the activation signal by reducing mitochondrial damage, ROS production, lysosomal rupture, c‐Jun N‐terminal kinases 1/2 phosphorylation and apoptosis‐associated speck‐like protein oligomerization. Furthermore, we found that TGP inhibited the NLRP3 inflammasome partially via autophagy induction. In the in vivo mouse model of uric acid crystal‐induced peritonitis, TGP attenuated the peritoneal recruitment of neutrophils, and the levels of IL‐1β, active caspase‐1, IL‐6 and monocyte chemoattractant protein‐1 in lavage ﬂuids. As a proof of principle, in this study, we purified a known compound, propolin G, from TGP and identified this compound as a potential inhibitor of the NLRP3 inflammasome. Our results indicated that TGP might be useful for ameliorating gouty inflammation via inhibition of the NLRP3 inflammasome.
Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells
Han-Ying Wu, Feng-Ling Yang, Lan-Hui Li, Yerra Koteswara Rao, Tz-Chuen Ju, et al.
Scientific Reports, 2018
As part of our ongoing search for novel therapeutic structures from microorganism, the chemical examination of marine fungus Phoma sp. resulted in the isolation of ergosterol, ergosterol peroxide (EP), and 9,11-dehydroergosterol peroxide (DEP). The bioassay results demonstrated that the three isolates reduced the viability of various cancer cells, with EP being highest in human lung cancer cell line A549 cells. EP induced caspase-dependent apoptosis through mitochondrial damage in A549 cells. Additionally, EP-induced ROS generation and apoptosis were attenuated by ROS-generating enzymes inhibitors and antioxidant N-acetylcysteine, indicated that ROS played an important role in EP-mediated apoptosis in A549 cells. Furthermore, it was observed that EP induced ROS-dependent autophagy, which attenuated apoptosis in A549 cells. On the other hand, EP reduced the LPS/ATP-induced proliferation and migration of A549 cells through attenuated NLRP3 inflammasome activity. Additionally, EP showed synergistic cytotoxic effect with antitumor drug Sorafenib in A549 cell viability inhibition. Furthermore, Micro-Western Array and Western blot analyses demonstrated that the protein levels of EGFR, HSP27, MEK5, AKT1, mTOR, Smad2, Smad3, TAB1, NF-κB, and HIF1-α decreased, while the levels of p-p38α, p-ERK1/2, p-JNK, fibronectin and p27 increased. Collectively, the results of this study demonstrated that EP might be useful to develop a therapeutic candidate for lung cancer complications.
Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome
Wei-Ting Wong, Lan-Hui Li, Yerra Koteswara Rao, Shih-Ping Yang, Shu-Meng Cheng, et al.
Frontiers in Immunology, 2018
In vitro production of echioidinin, 7-O-methywogonin from callus cultures of Andrographis lineata and their cytotoxicity on cancer cells
Arifullah Mohammed, Kishore K. Chiruvella, Yerra Koteswara Rao, Madamanchi Geethangili, Sathees C. Raghavan, et al.
Plos One, 2015
4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype
Tung-Cheng Chang, Chi-Tai Yeh, Bamodu Oluwaseun Adebayo, Ying-Chin Lin, Li Deng, et al.
Toxicology and Applied Pharmacology, 2015
A cyclohexadepsipeptide from entomogenous fungi Metarhizium anisopliae inhibits the Helicobacter pylori induced pathogenesis through attenuation of vacuolating cytotoxin-A activity
Min-Chuan Kao, Yerra Koteswara Rao, Yu-Wen Hsieh, Shih-Hsien Weng, Tzu-Li Lu, et al.
Process Biochemistry, 2015
Purification of kavalactones from Alpinia zerumbet and their protective actions against hydrogen peroxide-induced cytotoxicity in PC12 cells
Yerra Koteswara Rao, Hui-Nung Shih, Yi-Ching Lee, Wen-Tai Cheng, Hui-Chin Hung, et al.
Journal of Bioscience and Bioengineering, 2014
Destruxin B inhibits hepatocellular carcinoma cell growth through modulation of the Wnt/β-catenin signaling pathway and epithelial-mesenchymal transition
Thanh-Tuan Huynh, Yerra Koteswara Rao, Wei-Hwa Lee, Hsin-An Chen, T. Do-Quyen Le, et al.
Toxicology in Vitro, 2014
3,3',4',5'-tetramethoxychalcone inhibits human oral cancer cell proliferation and migration via p53-mediated mitochondrial-dependent apoptosis
Anticancer Research, 2014
A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells
Chi-Tai Yeh, Wen-Chien Huang, Yerra Koteswara Rao, Min Ye, Wei-Hwa Lee, et al.
Carcinogenesis, 2013
Development of a high performance liquid chromatography method for the quantitative determination of bioactive triterpenoids in the extracts of Antrodia camphorata
Yerra Koteswara Rao, Madamanchi Geethangili, Yew-Min Tzeng
Analytical Methods, 2013
Ovatodiolide inhibits the maturation of allergen-induced bone marrow-derived dendritic cells and induction of Th2 cell differentiation
Yerra Koteswara Rao, Yu-Ching Chen, Shih-Hua Fang, Chih-Ho Lai, Madamanchi Geethangili, et al.
International Immunopharmacology, 2013
Inhibition of helicobacter pylori CagA-induced pathogenesis by methylantcinate B from Antrodia camphorata
Chun-Jung Lin, Yerra Koteswara Rao, Chiu-Lien Hung, Chun-Lung Feng, Hsien-Yuan Lane, et al.
Evidence Based Complementary and Alternative Medicine, 2013
Aqueous extract of Anisomeles indica and its purified compound exerts anti-metastatic activity through inhibition of NF-κB/AP-1-dependent MMP-9 activation in human breast cancer MCF-7 cells
Ya-Fan Liao, Yerra Koteswara Rao, Yew-Min Tzeng
Food and Chemical Toxicology, 2012
Anticancer effects of eleven triterpenoids derived from Antrodia camphorata
Anticancer Research, 2012
Antibacterial activities of Anisomeles indica constituents and their inhibition effect on Helicobacter pylori-induced inflammation in human gastric epithelial cells
Yerra Koteswara Rao, Hsiu-Man Lien, Yu-Hsin Lin, Yuan-Man Hsu, Chi-Tai Yeh, et al.
Food Chemistry, 2012
Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging
Chi-Tai Yeh, Yerra Koteswara Rao, Min Ye, Wen-Shi Wu, Tung-Chen Chang, et al.
Toxicology and Applied Pharmacology, 2012
Effects of andrographolide and 14-deoxy-11,12-didehydroandrographolide on cultured primary astrocytes and PC12 cells
Yew-Min Tzeng, Yi-Ching Lee, Wen-Tai Cheng, Hui-Nung Shih, Huang-chi Wang, et al.
Life Sciences, 2012
Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway
Yun-Chih Hsieh, Yerra Koteswara Rao, Jacqueline Whang-Peng, Chi-Ying F. Huang, Song-Kun Shyue, et al.
Journal of Agricultural and Food Chemistry, 2011
Insulin-mimetic action of rhoifolin and cosmosiin isolated from citrus grandis (L.) osbeck leaves: Enhanced adiponectin secretion and insulin receptor phosphorylation in 3T3-L1 cells
Yerra Koteswara Rao, Meng-Jen Lee, Keru Chen, Yi-Ching Lee, Wen-Shi Wu, et al.
Evidence Based Complementary and Alternative Medicine, 2011
Identification of antrocin from antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB-231 cells
Yerra Koteswara Rao, Alexander T. H. Wu, Madamanchi Geethangili, Ming-Te Huang, Wan-Ju Chao, et al.
Chemical Research in Toxicology, 2011
Chalcone HTMC causes in vitro selective cytotoxicity, cell-cycle G 1 phase arrest through p53-dependent pathway in human lung adenocarcinoma A549 cells, and in vivo tumor growth suppression
Yerra Koteswara Rao, Te-Yu Kao, Jiunn-Liang Ko, Yew-Min Tzeng
Bioorganic and Medicinal Chemistry Letters, 2010
Andrographolide and 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata attenuate high glucose-induced fibrosis and apoptosis in murine renal mesangeal cell lines
Meng-Jen Lee, Yerra Koteswara Rao, Keru Chen, Yi-Ching Lee, Yi-Shuan Chung, et al.
Journal of Ethnopharmacology, 2010
Identification of small molecule inhibitors of telomerase activity through transcriptional regulation of hTERT and calcium induction pathway in human lung adenocarcinoma A549 cells
Yerra Koteswara Rao, Te-Yu Kao, Ming-Fang Wu, Jiunn-Liang Ko, Yew-Min Tzeng
Bioorganic and Medicinal Chemistry, 2010
Methylantcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway
Wan-Chi Tsai, Yerra Koteswara Rao, Shih-Shen Lin, Ming-Yung Chou, Yi-Ting Shen, et al.
Bioorganic and Medicinal Chemistry Letters, 2010
Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells
Chih-Ho Lai, Yerra Koteswara Rao, Shih-Hua Fang, Yu-Ting Sing, Yew-Min Tzeng
Bioorganic and Medicinal Chemistry Letters, 2010
Constituents isolated from Cordyceps militaris suppress enhanced inflammatory mediator's production and human cancer cell proliferation
Yerra Koteswara Rao, Shih-Hua Fang, Wen-Shi Wu, Yew-Min Tzeng
Journal of Ethnopharmacology, 2010
Methyl antcinate a from antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and bax-triggered mitochondrial pathway
Yun-Chih Hsieh, Yerra Koteswara Rao, Chun-Chi Wu, Chi-Ying F. Huang, Madamanchi Geethangili, et al.
Chemical Research in Toxicology, 2010
Inhibitory effect of Antrodia camphorata constituents on the Helicobacter pylori-associated gastric inflammation
Madamanchi Geethangili, Shih-Hua Fang, Chih-Ho Lai, Yerra Koteswara Rao, Hsiu-Man Lien, et al.
Food Chemistry, 2010
Synthesis and biological evaluation of 3′,4′,5′-trimethoxychalcone analogues as inhibitors of nitric oxide production and tumor cell proliferation
Yerra Koteswara Rao, Shih-Hua Fang, Yew-Min Tzeng
Bioorganic and Medicinal Chemistry, 2009
Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells
Chi-Tai Yeh, Yerra Koteswara Rao, Chih-Jung Yao, Chuan-Feng Yeh, Chi-Han Li, et al.
Cancer Letters, 2009
Effect of flavonol glycosides from Cinnamomum osmophloeum leaves on adiponectin secretion and phosphorylation of insulin receptor-β in 3T3-L1 adipocytes
Meng-Jen Lee, Yerra Koteswara Rao, Keru Chen, Yi-Ching Lee, Yew-Min Tzeng
Journal of Ethnopharmacology, 2009
Direct characterization and quantification of volatile organic compounds by piezoelectric module chips sensor
Hsin-Hsien Lu, Yerra Koteswara Rao, Tzong-Zeng Wu, Yew-Min Tzeng
Sensors and Actuators B Chemical, 2009
Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3-L1 adipocytes
Yew-Min Tzeng, Keru Chen, Yerra Koteswara Rao, Meng-Jen Lee
European Journal of Pharmacology, 2009
The constituents of Anisomeles indica and their anti-inflammatory activities
Yerra Koteswara Rao, Shih-Hua Fang, Shih-Chuan Hsieh, Tsung-Hsien Yeh, Yew-Min Tzeng
Journal of Ethnopharmacology, 2009
Probing inhibitory effects of Antrodia camphorata isolates using insect cell-based impedance spectroscopy: Inhibition vs chemical structure
Keith B. Male, Yerra Koteswara Rao, Yew-Min Tzeng, Johnny Montes, Amine Kamen, et al.
Chemical Research in Toxicology, 2008
Cytotoxic constituents from Andrographis paniculata induce cell cycle arrest in Jurkat cells
Madamanchi Geethangili, Yerra Koteswara Rao, Shih‐Hua Fang, Yew‐Min Tzeng
Phytotherapy Research, 2008
Inhibition of Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Phyllanthus urinaria extracts
Chih-Ho Lai, Shih-Hua Fang, Yerra Koteswara Rao, Madamanchi Geethangili, Chih-Hsin Tang, et al.
Journal of Ethnopharmacology, 2008
Antiinflammatory activities of flavonoids and a triterpene caffeate isolated from Bauhinia variegata
Yerra Koteswara Rao, Shih‐Hua Fang, Yew‐Min Tzeng
Phytotherapy Research, 2008
Inhibition of pro-inflammatory mediators and tumor cell proliferation by Anisomeles indica extracts
Shih-Chuan Hsieh, Shih-Hua Fang, Yerra Koteswara Rao, Yew-Min Tzeng
Journal of Ethnopharmacology, 2008
Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria
Shih-Hua Fang, Yerra Koteswara Rao, Yew-Min Tzeng
Journal of Ethnopharmacology, 2008
Effect of cultivation conditions on spore production from Bacillus amyloliquefaciens B128 and its antagonism to Botrytis elliptica
Y.-M. Tzeng, Y.K. Rao, K.-J. Tsay, W.-S. Wu
Journal of Applied Microbiology, 2008
Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts
Yerra Koteswara Rao, Shih-Hua Fang, Yew-Min Tzeng
Journal of Ethnopharmacology, 2007
Antioxidant and cytotoxic activities of naturally occurring phenolic and related compounds: A comparative study
Yerra Koteswara Rao, Madamanchi Geethangili, Shih-Hua Fang, Yew-Min Tzeng
Food and Chemical Toxicology, 2007
Highly regio- and stereoselective ring-opening of epoxides and aziridines with sodium azide using ammonium-12-molybdophosphate
Biswanath Das, Vtukuri Saidi Reddy, Maddeboina Krishnaiah, Yerra Koteswara Rao
Journal of Molecular Catalysis A Chemical, 2007
Medium optimization of carbon and nitrogen sources for the production of spores from Bacillus amyloliquefaciens B128 using response surface methodology
Yerra Koteswara Rao, Kuen-Juh Tsay, Wen-Shi Wu, Yew-Min Tzeng
Process Biochemistry, 2007
Zirconium tetrachloride catalysed synthesis of symmetric and unsymmetric ethers from secondary benzylic alcohols
Biswanath Das, Maddeboina Krishnaiah, Boyapati Veeranjaneyulu, Yallamalla Srinivas, Yerra Koteswara Rao
Journal of Chemical Research, 2007
A simple and efficient one-pot synthesis of 1,4-dihydropyridines using heterogeneous catalyst under solvent-free conditions
Muchchintala Maheswara, Vidavalur Siddaiah, Yerra Koteswara Rao, Yew-Min Tzeng, Chenchugari Sridhar
Journal of Molecular Catalysis A Chemical, 2006
Antioxidants enhanced production of destruxin E from cultivation of Metarhizium anisopliae
Yerra Koteswara Rao, Chia-Heng Tsou, Yew-Min Tzeng
Applied Microbiology and Biotechnology, 2006
Biological evaluation of sulfone derivatives as anti-inflammatory and tumor cells growth inhibitory agents
Shih-Hua Fang, V. Padmavathi, Yerra Koteswara Rao, D.R.C. Venkata Subbaiah, P. Thriveni, et al.
International Immunopharmacology, 2006
A new biflavonoid from Cycas beddomei
Indian Journal of Chemistry Section B Organic and Medicinal Chemistry, 2006
A solvent-free synthesis of coumarins via Pechmann condensation using heterogeneous catalyst
Muchchintala Maheswara, Vidavalur Siddaiah, Guri Lakishmi Vasantha Damu, Yerra Koteswara Rao, Chunduri Venkata Rao
Journal of Molecular Catalysis A Chemical, 2006
A mild and facile synthesis of substituted pyrroles using silica supported sodium hydrogen sulfate as a heterogeneous catalyst
Indian Journal of Heterocyclic Chemistry, 2006
A simple and rapid method for identification and determination of cordycepin in Cordyceps militaris by capillary electrophoresis
Yerra Koteswara Rao, Chia-Hsien Chou, Yew-Min Tzeng
Analytica Chimica Acta, 2006
Acylated 5,7,2′,6′-oxygenated flavone glycosides from Andrographis alata
Biswanath Das, R. Ramu, Yerra Koteswara Rao, M. Ravinder Reddy, H. Harish, et al.
Phytochemistry, 2006
Solid phase extraction of Cd, Cu, and Ni from leafy vegetables and plant leaves using amberlite XAD-2 functionalized with 2-hydroxy-acetophenone- thiosemicarbazone (HAPTSC) and determination by inductively coupled plasma atomic emission spectroscopy
G. Purna Chandra Rao, Kalluru Seshaiah, Yerra Koteswara Rao, M. C. Wang
Journal of Agricultural and Food Chemistry, 2006
Amberlyst-15: An efficient reusable heterogeneous catalyst for the synthesis of 1,8-dioxo-octahydroxanthenes and 1,8-dioxo-decahydroacridines
Biswanath Das, Ponnaboina Thirupathi, I. Mahender, V. Saidi Reddy, Yerra Koteswara Rao
Journal of Molecular Catalysis A Chemical, 2006
Pseudoguaianolides from the flowers of Parthenium hysterophorus
Biswanath Das, Gurram Mahender, Yerra Koteswara Rao, Chimmani Ramesh, Katta Venkateswarlu, et al.
Helvetica Chimica Acta, 2006
New clerodane diterpenoids from the aerial parts of Pulicaria wightiana)
Biswanath Das, Ravirala Ramu, Katta Venkateswarlu, Yerra Koteswara Rao, Majjigapu Ravinder Reddy, et al.
Chemistry and Biodiversity, 2006
Solid phase extraction of trace metals in seawater using morpholine dithiocarbamate-loaded Amberlite XAD-4 and determination by ICP-AES
G. Purna Chandra Rao, S. Satya Veni, K. Pratap, Yerra Koteswara Rao, K. Seshaiah
Analytical Letters, 2006
Highly efficient, mild and chemo- and stereoselective synthesis of enaminones and enamino esters using silica supported perchloric acid under solvent-free conditions
Biswanath Das, Katta Venkateswarlu, Anjoy Majhi, Majjigapu Ravinder Reddy, Kuravallapalli Nagabhushana Reddy, et al.
Journal of Molecular Catalysis A Chemical, 2006
Enhanced production of an extracellular protease from Beauveria bassiana by optimization of cultivation processes
Yerra Koteswara Rao, Shih-Chin Lu, Bing-Lan Liu, Yew-Min Tzeng
Biochemical Engineering Journal, 2006
Anti-inflammatory activities of constituents isolated from Phyllanthus polyphyllus
Yerra Koteswara Rao, Shih-Hua Fang, Yew-Min Tzeng
Journal of Ethnopharmacology, 2006
Antibacterial activity of acylated flavonol glycoside from Waltheria indica
Asian Journal of Chemistry, 2006
Isolation of new chalcone from the leaves of Bauhinia variegata
Asian Journal of Chemistry, 2006
Synthesis, growth inhibition, and cell cycle evaluations of novel flavonoid derivatives
Yerra Koteswara Rao, Shih-Hua Fang, Yew-Min Tzeng
Bioorganic and Medicinal Chemistry, 2005
Anti-inflammatory activities of flavonoids isolated from Caesalpinia pulcherrima
Yerra Koteswara Rao, Shih-Hua Fang, Yew-Min Tzeng
Journal of Ethnopharmacology, 2005
Inhibitory effects of the flavonoids isolated from waltheria indica on the production of NO, TNF-α and IL-12 in activated macrophages
Yerra Koteswara Rao, Shih-Hua Fang, Yew-Min Tzeng
Biological and Pharmaceutical Bulletin, 2005
(E)-1-(2-Hydroxy-3,4-dimethoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
J. Radha Krishna, N. Jagadeesh Kumar, M. Krishnaiah, C. Venkata Rao, Y. Koteswara Rao, et al.
Acta Crystallographica Section E Structure Reports Online, 2005
Inhibitory effects of flavonol glycosides from Cinnamomum osmophloeum on inflammatory mediators in LPS/IFN-γ-activated murine macrophages
Shih-Hua Fang, Yerra Koteswara Rao, Yew-Min Tzeng
Bioorganic and Medicinal Chemistry, 2005
Biflavonoids from Cycas beddomei
Biswanath Das, Gurram Mahender, Yerra Koteswara Rao, Anabathula Prabhakar, Bharatam Jagadeesh
Chemical and Pharmaceutical Bulletin, 2005
Synthesis of pyrano and furanoquinolines using silica chloride or amberlyst-15 as a heterogeneous catalyst
Biswanath Das, Majjigapu Ravinder Reddy, Harish Holla, Ravirala Ramu, Katta Venkateswarlu, et al.
Journal of Chemical Research, 2005
A new highly oxygenated pseudoguaianolide from a collection of the flowers of Parthenium hysterophorus
Ratna Das, Madamanchi Geethangili, Anjoy Majhi, Biswanath Das, Yerra Koteswara Rao, et al.
Chemical and Pharmaceutical Bulletin, 2005
Clerodane diterpenoids from Pulicaria wightiana
Biswanath Das, M. Ravinder Reddy, R. Ramu, N. Ravindranath, H. Harish, et al.
Phytochemistry, 2005
Flavonoids and andrographolides from Andrographis paniculata
Y. Koteswara Rao, G. Vimalamma, C. Venkata Rao, Yew-Min Tzeng
Phytochemistry, 2004
Two new 5-deoxyflavonoids from Calliandra inermis
Muchchintala Maheswara, Yerra Koteswara Rao, Vidavalur Siddaiah, Chunduri Venkata Rao, Kasi Viswanatham Somayajulu, et al.
Chemical and Pharmaceutical Bulletin, 2004
Differential effects of synthesized 2′-oxygenated chalcone derivatives: Modulation of human cell cycle phase distribution
Yerra Koteswara Rao, Shih-Hua Fang, Yew-Min Tzeng
Bioorganic and Medicinal Chemistry, 2004
Flavonoids from Andrographis viscosula
Yerra Koteswara Rao, Amooru Gangaiah Damu, Alahari Janardhan Rao, Shanmuganathan Venkatesan, Ping-Chung Kuo, et al.
Chemical and Pharmaceutical Bulletin, 2003
Flavanoids from Caesalpinia pulcherrima
K.V.N.S Srinivas, Y Koteswara Rao, I Mahender, Biswanath Das, K.V.S Rama Krishna, et al.
Phytochemistry, 2003
Flavones from Andrographis viscosula
Y.Koteswara Rao, P. Harikishore, C.Venkata Rao, D. Gunasekar, A. Blond, et al.
Phytochemistry, 2002
Two new 5-deoxyflavones from Albizia odoratissima
Yerra Koteswara Rao, Mopur Vijaya Bhaskar Reddy, Chunduri Venkata Rao, Duvvuru Gunasekar, Alan Blond, et al.
Chemical and Pharmaceutical Bulletin, 2002
Total synthesis of heliannone A and (R,S)-heliannone B, two bioactive flavonoids from Helianthus annuus cultivars
Y. Koteswara Rao, C. Venkata Rao, P. Hari Kishore, D. Gunasekar
Journal of Natural Products, 2001

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