Aparna Yeddala

EDUCATION

PhD from Osmania University
MPhil from Vinayaka missions University
MSc Chemistry from Osmania University College for Women
from Osmania University College for Women
Intermediate from Mother's Girls
X (ICSE) from Sri Sai Public School.

RESEARCH INTERESTS

Organic synthesis of heterocyclic compounds bearing oxazole, imidazole and imidazolone rings. Molecular docking studies and and bacterial studies

Scopus Publications

Microwave assisted synthesis of new quinolone and coumarin molecular hybrids: SAR, molecular modelling studies as dual antagonists and its antimicrobial evaluation targeting bacterial and fungal infections
Tella Lakshmi Viveka, Gangadhara Angajala, Valmiki Aruna, Mamatha Nakka, Yeddala Aparna
Journal of Molecular Structure, 2024
Synthesis, Antimicrobial Evaluation, and In Silico Molecular Docking Studies of Chalcone-Based 1,2,3-Triazoles
Ch. Prasad, P. Nagesh, Ch. Kishan, V. Murali Krishna, A. Balaswamy, V. Manga, B. Prashanth, Y. Aparna
Russian Journal of General Chemistry, 2023
Abstract A series of chalcone-based 1,2,3-triazole compounds was synthesized Condensation of aldehydes and ketones results in the formation of chalcones. Terminal alkyne of chalcones and different aryl azides cyclization produced chalcone-based 1,2,3-triazoles through 1,3-dipolar cycloaddition (click reaction). The compounds were screened to evaluate their in vitro antimicrobial activities against Bacillus cereus, Escherichia coli bacteria and Aspergillus niger fungal strains. The analogues of 2-methyl, 4-chloro, 3-trifluormethyl, ester and 3,5-dichloro substitutions showed excellent zone of inhibition compared to ampicillin and bavistin drugs. Molecular docking studies showed good binding interactions with selected proteins glucosamine-6-phosphate and 3-phytase A of E. coli and A. niger, respectively.
1-(3-acetyl phenyl)-4-(4-arylidene)-2-phenyl-1h-imidazol-5(4h)-ones: Synthesis, spectroscopic characterization, antimicrobial and molecular docking studies
Y. Aparna, D. Sandhya, N. J. P. Subhashini, L. N. Sharada
Rasayan Journal of Chemistry, 2021
Imidazole rings are privileged moieties in heterocyclic chemistry since they permit functional group and structural modifications to synthesize abundant substituted heterocycles. Thus, the pursuit of exploring many more alterations on imidazole moiety needs to be continued. In the present work an array of the new imidazolone derivatives was prepared as per the expedient method. The moieties were characterized by FTIR,1HNMR, 13CNMR and Mass spectra. Docking was studied to exemplify the binding connections of intended scaffolds with the crystal structure of proteinreductase of Staphylococcusaureus pdbid:4NZ9.The synthesized compounds were tested for antibacterial activity by the agar diffusion method. All the compounds showed potent activity against diverse bacterial species.
Synthesis and Antimicrobial Activity of Novel Bis-1,2,3-triazol-1H-4-yl-substituted Aryl Benzimidazole-2-thiol Derivatives
Y. Aparna, G. Nirmala, N. J. P. Subhashini, L. N. Sharada, Sivan Sreekanth
Russian Journal of General Chemistry, 2020
Novel bis-1,2,3-triazol-1H-4-yl-substituted aryl benzimidazole-2-thiol derivatives have been synthesized from 5-methoxy and 5-difluoromethoxy bis-propargyl substituted benzimidazole-2-thiols using the “click chemistry,” tested for their antimicrobial activity and subjected to molecular docking studies. Structures of the compounds have been elucidated from IR, NMR, and mass spectra.
Ternary Cu(II) complexes: synthesis, structural elucidation, and biological studies (DNA binding, cleavage, antibacterial, cytotoxicity)
L. N. Sharada, S. N. T. Sunitha, Maryam Sabha, T. L. Viveka, Y. Aparna, M. Prasad
Research on Chemical Intermediates, 2020
Synthesis, Characterization, Molecular Docking, and Antimicrobial Activity of New Arylidene-Substituted Imidazoles
Y. Aparna, L. N. Sharada, N. J. P. Subhashini, Sivan Sreekanth
Russian Journal of General Chemistry, 2019
The title compounds are synthesized by condensation of 2-[4-(arylidene)-5-oxo-4, 5-dihydrooxazol-2-yl]phenylacetate with aromatic amines in presence of the Vilsemeier Haack reagent. Structures of all compounds are elucidated from 1H and 13C NMR, IR, and mass spectra. The compounds are tested for their antibacterial activity. Molecular docking study is focused on the relative orientation and nature of bonding between imidazoles and bacterial protein.

RECENT SCHOLAR PUBLICATIONS

Substituted Arylidene Imidazolones: Synthesis, Spectral Characterization and Molecular Docking Studies
Y Aparna, NJP Subhashini
Chemistry and Biochemistry: Research Progress Vol. 9, 103-113 , 2026
2026
Microwave assisted synthesis of new quinolone and coumarin molecular hybrids: SAR, molecular modelling studies as dual antagonists and its antimicrobial evaluation targeting …
TL Viveka, G Angajala, V Aruna, M Nakka, Y Aparna
Journal of Molecular Structure 1303, 137482 , 2024
2024
Citations: 4
ANTIBACTERIAL ACTIVITY AND RELATED ISSUES OF NATURAL DYES IN TEXTILES, THEIR EFFECTIVE DATA ANALYSIS
YA K. Sai Srikari , T. Vishnu , K. Nagaiah
Heterocyclic Letters 13 (4), 737-745 , 2023
2023
Synthesis, Antimicrobial Evaluation, and In Silico Molecular Docking Studies of Chalcone-Based 1,2,3-Triazoles
BPYA Ch. Prasad, P. Nagesh, Ch. Kishan, V. Murali Krishna, A. Balaswamy, V ...
Russian journal of General Chemistry 93 (5), 1162 - 1170 , 2023
2023
Citations: 3
An Assessment on Oxazolones-their Reactions and Applications
Y Aparna
Novel Aspects on Chemistry and Biochemistry Vol. 1 1, 121-136 , 2023
2023
ANTIFUNGAL ACTIVITY, MOLECULAR DOCKING ON COVID-19 MAIN PROTEASE AND PHARMACOKINETICS OFIMIDAZOLONE ANALOGUES
YA T.Vishnua ,K.Sandhyaa ,K.ArunaKumaria
Heterocyclic letters 13 (1), 93-104 , 2023
2023
A Heterogeneous approach to synthesis of azlactones
Y Aparna
International journal of Pharmaceutical research and applications 7 (02 … , 2022
2022
Synthesis, Spectral characterization, DNA binding, and Antimicrobial studies of Cu(II), Ni(II) and Co(II) Binary metal complexes derived from 1-(2- methyl-1H-indol-5-ylimino …
YA L.N.Sharada, Maryam Sabha, SNT Sunita
International Journal of research and analytical reviews 8 (5), 837-849 , 2021
2021
1-(3-ACETYL PHENYL)-4-(4-ARYLIDENE)-2-PHENYL-1H-IMIDAZOL-5 (4H)-ONES: SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION, ANTIMICROBIAL AND MOLECULAR DOCKING STUDIES
Y Aparna, D Sandhya, NJP Subhashini, LN Sharada
Rasayan Journal of Chemistry 14 (4) , 2021
2021
A comparative study of Oxazolones and imidazolones-A review
Y Aparna
IJARBEST 7 (9), 16-34 , 2021
2021
Cytotoxic activity, corrosion inhibition activity and molecular docking studies of Imidazolone scaffolds-A review
LNS Y Aparna1 , NJP Subhashini2
International Journal of Advanced Chemistry Research 3 (1, 2021), 19-24 , 2021
2021
Synthesis and Antimicrobial Activity of Novel Bis-1,2,3-triazol-1 H -4-yl-substituted Aryl Benzimidazole-2-thiol Derivatives
Y Aparna, G Nirmala, NJP Subhashini, LN Sharada, S Sreekanth
Russian Journal of General Chemistry 90 (8), 1501-1506 , 2020
2020
Citations: 15
Ternary Cu (II) complexes: synthesis, structural elucidation, and biological studies (DNA binding, cleavage, antibacterial, cytotoxicity)
LN Sharada, SNT Sunitha, M Sabha, TL Viveka, Y Aparna, M Prasad
Research on Chemical Intermediates 46 (7), 3341-3360 , 2020
2020
Citations: 10
Synthesis, Characterization, Molecular Docking, and Antimicrobial Activity of New Arylidene-Substituted Imidazoles
Y Aparna, LN Sharada, NJP Subhashini, S Sreekanth
Russian Journal of General Chemistry 89 (6), 1202-1208 , 2019
2019
Citations: 7
ANTIMICROBIAL & ANTIFUNGAL ACTIVITY OF SUBSTITUTED 4-ARYLIDENE 2-(HYDROXY PHENYL) OXAZOL-5(4H)-ONES
LNS 1Y. Aparna
International Journal of Creative Research Thoughts, 346-352 , 2018
2018
Synthesis, Characterization and Molecular Docking Studies Of New Erlenmeyer Azlactones
LV 1Prof L. N. Sharada*, 2Y.Aparna, 3Saba, 4Sunita
IOSR Journal of Applied Chemistry (IOSR-JAC) 8 (Issue 8 Ver. II), PP 30-36 , 2015
2015
A Review on Reactions and Applications of Oxazolones
LN Sharada, Y Aparna, M Saba, SNT Sunitha, L Viveka
International Journal of Scientific and Research Publication 5, 1-9 , 2015
2015
Citations: 9
SYNTHESIS AND ANTI-MICROBIAL AGENTS OF NOVEL (E)-N'-4, 4’-DIFLUORO-CYCLOHEXANECARBOXYLIC ACID (SUBSTITUTED-BENZYLIDENE)-HYDRAZIDE DERIVATIVES
LNS Tella.Lakshmi Viveka, Mariyam Saba, S.N.T.Sunitha, Y.Aparna
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 4 (05), 1087-1105 , 2015
2015
Azlactones in heterocyclic synthesis: Part-V-Condensation of Azlactones with 4-nitrobenzene-1, 2-diamine
Y Aparna, NJP Subhashini
J. Chem. Pharm. Res 2 (3), 473-477 , 2010
2010

MOST CITED SCHOLAR PUBLICATIONS

Synthesis and Antimicrobial Activity of Novel Bis-1,2,3-triazol-1 H -4-yl-substituted Aryl Benzimidazole-2-thiol Derivatives
Y Aparna, G Nirmala, NJP Subhashini, LN Sharada, S Sreekanth
Russian Journal of General Chemistry 90 (8), 1501-1506 , 2020
2020
Citations: 15
Ternary Cu (II) complexes: synthesis, structural elucidation, and biological studies (DNA binding, cleavage, antibacterial, cytotoxicity)
LN Sharada, SNT Sunitha, M Sabha, TL Viveka, Y Aparna, M Prasad
Research on Chemical Intermediates 46 (7), 3341-3360 , 2020
2020
Citations: 10
A Review on Reactions and Applications of Oxazolones
LN Sharada, Y Aparna, M Saba, SNT Sunitha, L Viveka
International Journal of Scientific and Research Publication 5, 1-9 , 2015
2015
Citations: 9
Synthesis, Characterization, Molecular Docking, and Antimicrobial Activity of New Arylidene-Substituted Imidazoles
Y Aparna, LN Sharada, NJP Subhashini, S Sreekanth
Russian Journal of General Chemistry 89 (6), 1202-1208 , 2019
2019
Citations: 7
Microwave assisted synthesis of new quinolone and coumarin molecular hybrids: SAR, molecular modelling studies as dual antagonists and its antimicrobial evaluation targeting …
TL Viveka, G Angajala, V Aruna, M Nakka, Y Aparna
Journal of Molecular Structure 1303, 137482 , 2024
2024
Citations: 4
Synthesis, Antimicrobial Evaluation, and In Silico Molecular Docking Studies of Chalcone-Based 1,2,3-Triazoles
BPYA Ch. Prasad, P. Nagesh, Ch. Kishan, V. Murali Krishna, A. Balaswamy, V ...
Russian journal of General Chemistry 93 (5), 1162 - 1170 , 2023
2023
Citations: 3
Substituted Arylidene Imidazolones: Synthesis, Spectral Characterization and Molecular Docking Studies
Y Aparna, NJP Subhashini
Chemistry and Biochemistry: Research Progress Vol. 9, 103-113 , 2026
2026
ANTIBACTERIAL ACTIVITY AND RELATED ISSUES OF NATURAL DYES IN TEXTILES, THEIR EFFECTIVE DATA ANALYSIS
YA K. Sai Srikari , T. Vishnu , K. Nagaiah
Heterocyclic Letters 13 (4), 737-745 , 2023
2023
An Assessment on Oxazolones-their Reactions and Applications
Y Aparna
Novel Aspects on Chemistry and Biochemistry Vol. 1 1, 121-136 , 2023
2023
ANTIFUNGAL ACTIVITY, MOLECULAR DOCKING ON COVID-19 MAIN PROTEASE AND PHARMACOKINETICS OFIMIDAZOLONE ANALOGUES
YA T.Vishnua ,K.Sandhyaa ,K.ArunaKumaria
Heterocyclic letters 13 (1), 93-104 , 2023
2023
A Heterogeneous approach to synthesis of azlactones
Y Aparna
International journal of Pharmaceutical research and applications 7 (02 … , 2022
2022
Synthesis, Spectral characterization, DNA binding, and Antimicrobial studies of Cu(II), Ni(II) and Co(II) Binary metal complexes derived from 1-(2- methyl-1H-indol-5-ylimino …
YA L.N.Sharada, Maryam Sabha, SNT Sunita
International Journal of research and analytical reviews 8 (5), 837-849 , 2021
2021
1-(3-ACETYL PHENYL)-4-(4-ARYLIDENE)-2-PHENYL-1H-IMIDAZOL-5 (4H)-ONES: SYNTHESIS, SPECTROSCOPIC CHARACTERIZATION, ANTIMICROBIAL AND MOLECULAR DOCKING STUDIES
Y Aparna, D Sandhya, NJP Subhashini, LN Sharada
Rasayan Journal of Chemistry 14 (4) , 2021
2021
A comparative study of Oxazolones and imidazolones-A review
Y Aparna
IJARBEST 7 (9), 16-34 , 2021
2021
Cytotoxic activity, corrosion inhibition activity and molecular docking studies of Imidazolone scaffolds-A review
LNS Y Aparna1 , NJP Subhashini2
International Journal of Advanced Chemistry Research 3 (1, 2021), 19-24 , 2021
2021
ANTIMICROBIAL & ANTIFUNGAL ACTIVITY OF SUBSTITUTED 4-ARYLIDENE 2-(HYDROXY PHENYL) OXAZOL-5(4H)-ONES
LNS 1Y. Aparna
International Journal of Creative Research Thoughts, 346-352 , 2018
2018
Synthesis, Characterization and Molecular Docking Studies Of New Erlenmeyer Azlactones
LV 1Prof L. N. Sharada*, 2Y.Aparna, 3Saba, 4Sunita
IOSR Journal of Applied Chemistry (IOSR-JAC) 8 (Issue 8 Ver. II), PP 30-36 , 2015
2015
SYNTHESIS AND ANTI-MICROBIAL AGENTS OF NOVEL (E)-N'-4, 4’-DIFLUORO-CYCLOHEXANECARBOXYLIC ACID (SUBSTITUTED-BENZYLIDENE)-HYDRAZIDE DERIVATIVES
LNS Tella.Lakshmi Viveka, Mariyam Saba, S.N.T.Sunitha, Y.Aparna
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 4 (05), 1087-1105 , 2015
2015
Azlactones in heterocyclic synthesis: Part-V-Condensation of Azlactones with 4-nitrobenzene-1, 2-diamine
Y Aparna, NJP Subhashini
J. Chem. Pharm. Res 2 (3), 473-477 , 2010
2010

Publications

QenVF8IAAAAJ (Google scholar ID)
57349605100 (Scopus ID)
57349605100 (ORCID)