VASANTH KUMAR E

@annauniv.edu

Teaching Fellow, Department Of Chemical Engineering
Anna University, Chennai

VASANTH KUMAR E


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https://researchid.co/vippiv44

RESEARCH INTERESTS

Hydrtropes, Adsorption, Process control
6

Scopus Publications

5

Scholar Citations

1

Scholar h-index

Scopus Publications

  • Hydrotrope dynamics: unraveling solubility pattern and correlation of benzimidazole using response surface methodology expert system
    Arunodhaya Natarajan, Umaiyambika Neduvel Annal, Vasanth Kumar Elakiyaasokan, Nagendra Gandhi Nagarajan
    Journal of Dispersion Science and Technology, 2025
    Solubilizing drugs in liquid and semisolid environments typically involves the use of cosolvents or surfactants. In contrast, the utilization of hydrotropic agents, which are small hydrophilic organic compounds like sodium salicylate or sodium benzoate, has been less explored in the field of pharmaceutical formulations. However, particularly in the context of topical dosage forms, hydrotropic solubilization can present valuable alternatives for enhancing solubility. One challenge in employing hydrotropic solubilization has been the unpredictability of its effectiveness with different drug molecules. In the current study, three different hydrotropes namely sodium salicylate, sodium benzoate, and pyrogallol were chosen to test the solubility enhancement of benzimidazole drug. Optimization of solubility was proceeded with Central Composite Design obtained from RSM expert system. It was noticed from the results that sodium salicylate had performed the best compared to the other two chosen hydrotropes. This was also reexamined using two models namely modified Apelblat model and polynomial model. The thermodynamic studies were assessed and it had reconfirmed the acquired solubility study results. The minimum and maximum hydrotrope concentrations of sodium salicylate required were 0.4 and 2.25 mol/L, respectively. The solubility enhancement factor was also remarkably high for sodium salicylate with 36.91 ± 0.07. With careful selection of the appropriate hydrotropic agent, the solubility of poorly soluble drug, benzimidazole has been significantly improved.
  • Aqueous solubility enhancement of theobromine using eco-friendly hydrotropic phenomena
    E. Vasanth Kumar, K. Kavyashri, P. G. Aakash, N. Nagendra Gandhi
    Chemical Engineering Communications, 2025
  • Aqueous Solubility Enhancement and Thermodynamic Aggregation Behavior of Resveratrol Using an Eco-Friendly Hydrotropic Phenomenon
    Vasanth Kumar Elakiyaasokan, Gayathri Kalyanaraman, Nagendra Gandhi Nagarajan
    Russian Journal of Physical Chemistry A, 2019
    Resveratrol, a stilbenoid polyphenol compound found in the skin and seeds of black grapes, which is supposed to have biological activity as an anti-inflammatory, anti-tumor, and anti-aging agent. Low oral bioavailability of resveratrol is determined by its low solubility in water. To overcome this, a biocompatible solubilization method is used to intensify the solubility of resveratrol. Hydrotropes (solubilizing agents) such as sodium caprylate, and sodium benzoate under a wide range of concentrations (0‒3 mol/L) and temperature (303–333 K) were used to study the aqueous solubility of resveratrol. It is observed that the solubility of resveratrol is enhanced by 16 times in the presence of sodium caprylate as hydrotrope. Thermodynamic properties like entropy, Gibbs free energy, and enthalpy were determined, and the solubilization process was found to be entropy-driven.
  • Preparation and charactersiation of low cost adsorbent from groundnut foliage by chemical activation
    , D. Vidhya Lakshmi, L. Anitha Jegadeeshwar, , N. Arunodhaya, , E. Vasanth Kumar, , N. Nagendra Gandhi, and
    Journal of Environmental Biology, 2018
    Effective treatment and management of wastewater and solid waste are the major challenges growing at an alarming rate in today's world. The aim of the present study was to find the feasibility of utilizing agro-based waste (groundnut foliage) as a low cost adsorbent for dye laden waste water treatment.
  • Tribal plants and their inborn antimicrobial activities
    Anitha Jegadeeshwari L, Dharathi N, Vidhya Lakshmi D, Vasanth Kumar E, Nagendra Gandhi N
    Asian Journal of Pharmaceutical and Clinical Research, 2017
    The importance of medicinal plants in traditional health-care practices provides clues to new areas of research and in the biodiversity of conservation. Right from the beginning, the documentation of traditional knowledge, especially on the medicinal uses of plants, has provided many important drugs for the modern day. Even today, this area holds much more hidden treasure as almost 80% of the human population in developing countries depend on plant resources for health care. Keeping this in view, the present study was initiated to document the traditionally used tribal plants and their inborn antimicrobial activity which is enhanced on the synthesis of noble metal nanoparticles.
  • Effect of hydrotropes on solubility, mass transfer coefficient and thermodynamic properties of the drug Meftal Spas
    Journal of Chemical and Pharmaceutical Sciences, 2016

RECENT SCHOLAR PUBLICATIONS

  • Aqueous solubility enhancement of theobromine using eco-friendlyhydrotropic phenomena
    NNG E. Vasanth Kumar, K. Kavyashri, P. G. Aakash
    Chemical Engineering Communications , 2024
    2024
  • Hydrotrope dynamics: unraveling solubility pattern and correlation of benzimidazole using response surface methodology expert system
    NGN Arunodhaya Natarajan, Umaiyambika Neduvel Annal, Vasanth Kumar Elakiya ...
    Journal Of Dispersion Science and Technology, https://doi.org/10.1080 … , 2024
    2024
  • Aqueous Solubility Enhancement and Thermodynamic Aggregation Behavior of Resveratrol Using an Eco - Friendly Hydrotropic Phenomenon
    V Kumar E, GKN Gandhi N
    Russsian Journal Of Physical Chemistry A 93 (13), 2681-2686 , 2020
    2020
    Citations: 5
  • Aqueous solubility enhancement of Naringenin a bioactive compound using an eco-friendly hydrotropic phenomenon
    NGN Vasanth Kumar E, Praveen P
    American International Journal of Research in Science, Technology … , 2019
    2019
  • Preparation and charactersiation of low cost adsorbent from groundnut foliage by chemical activation
    DV Lakshmi, LA Jegadeeshwari, N Arunodhaya, EV Kumar, NN Gandhi
    Journal of Environmental Biology 39 (3), 400-405 , 2018
    2018
  • TRIBAL PLANTS AND THEIR INBORN ANTIMICROBIAL ACTIVITIES
    VKE Nagendra Gandhi N Anitha Jegadeeshwari L, Dharathi N, Vidhya Lakshmi D
    Asian journal of pharmaceutical and clinical research 10 (7), 31-37 , 2017
    2017
  • Effect of hydrotropes on solubility, mass transfer coefficient and thermodynamic properties of the drug Meftal Spas
    L Anitha Jegadeeshwari, N Arunodhaya, E Vasanth Kumar, ...
    Journal of Chemical and Pharmaceutical Sciences 9 (1), 243-249 , 2016
    2016
  • Bio-availability Enhancement of Resveratrol Using an Eco Friendly Hydrotrophic Phenomenon
    EV Kumar, LA Jegadeeshwari, N Arunodhaya, D Vidhyalakshmi, ...
    Separation Technologies in Chemical, Biochemical, Petroleum and … , 2016
    2016
  • Solubility Measurement, Correlation and Step Wise Association of Benzimidazole in Different Hydrotropes at the Range of 303.15–333.15 k.
    N Arunodhaya, EV Kumar, LA Jegadeeshwari, D Vidhyalakshmi, ...
    Separation Technologies in Chemical, Biochemical, Petroleum and … , 2016
    2016

MOST CITED SCHOLAR PUBLICATIONS

  • Aqueous Solubility Enhancement and Thermodynamic Aggregation Behavior of Resveratrol Using an Eco - Friendly Hydrotropic Phenomenon
    V Kumar E, GKN Gandhi N
    Russsian Journal Of Physical Chemistry A 93 (13), 2681-2686 , 2020
    2020
    Citations: 5
  • Aqueous solubility enhancement of theobromine using eco-friendlyhydrotropic phenomena
    NNG E. Vasanth Kumar, K. Kavyashri, P. G. Aakash
    Chemical Engineering Communications , 2024
    2024
  • Hydrotrope dynamics: unraveling solubility pattern and correlation of benzimidazole using response surface methodology expert system
    NGN Arunodhaya Natarajan, Umaiyambika Neduvel Annal, Vasanth Kumar Elakiya ...
    Journal Of Dispersion Science and Technology, https://doi.org/10.1080 … , 2024
    2024
  • Aqueous solubility enhancement of Naringenin a bioactive compound using an eco-friendly hydrotropic phenomenon
    NGN Vasanth Kumar E, Praveen P
    American International Journal of Research in Science, Technology … , 2019
    2019
  • Preparation and charactersiation of low cost adsorbent from groundnut foliage by chemical activation
    DV Lakshmi, LA Jegadeeshwari, N Arunodhaya, EV Kumar, NN Gandhi
    Journal of Environmental Biology 39 (3), 400-405 , 2018
    2018
  • TRIBAL PLANTS AND THEIR INBORN ANTIMICROBIAL ACTIVITIES
    VKE Nagendra Gandhi N Anitha Jegadeeshwari L, Dharathi N, Vidhya Lakshmi D
    Asian journal of pharmaceutical and clinical research 10 (7), 31-37 , 2017
    2017
  • Effect of hydrotropes on solubility, mass transfer coefficient and thermodynamic properties of the drug Meftal Spas
    L Anitha Jegadeeshwari, N Arunodhaya, E Vasanth Kumar, ...
    Journal of Chemical and Pharmaceutical Sciences 9 (1), 243-249 , 2016
    2016
  • Bio-availability Enhancement of Resveratrol Using an Eco Friendly Hydrotrophic Phenomenon
    EV Kumar, LA Jegadeeshwari, N Arunodhaya, D Vidhyalakshmi, ...
    Separation Technologies in Chemical, Biochemical, Petroleum and … , 2016
    2016
  • Solubility Measurement, Correlation and Step Wise Association of Benzimidazole in Different Hydrotropes at the Range of 303.15–333.15 k.
    N Arunodhaya, EV Kumar, LA Jegadeeshwari, D Vidhyalakshmi, ...
    Separation Technologies in Chemical, Biochemical, Petroleum and … , 2016
    2016