Garla Venkateswarlu

@sharda.ac.in

Ph.D Research Scholar/ Pharmaceutical Chemistry
Delhi Institute of Pharmaceutical Sciences and Research

Garla Venkateswarlu


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https://researchid.co/venkatgarla

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science, Drug Discovery
6

Scopus Publications

Scopus Publications

  • Phytochemical Evaluation, GC-MS Analysis of Ethanol Extract of Endemic Plant of Boswellia ovalifoliolata Leaves
    Garla Venkateswarlu, Shashank K. Singh, Ramesh Bodla
    Journal of Natural Remedies, 2025
    Background: In many nations, medical plants are an important part of the basic healthcare systems. Plant medicinal properties are found by the biological substances present in the plant components that are used to produce medicinal remedies. Boswellia ovalifoliolata is classified under the Burseraceae family. It is extensively spread out in the Eastern Ghats of India. Traditionally, leaves of this plant have been extensively used to aliment leprosy, cancer, as an emetic, and for headaches. Aim: The current study used gas chromatography-mass-spectrometry analysis and phytochemical assessment to determine the phytochemical components of B. ovalifoliolata leaves. Methods: The shade-dried leaves were ground and extracted with ethanol using the cold maceration method; we conducted a phytochemical examination to evaluate the characteristics of secondary metabolites and used Gas Chromatography-Mass- Spectrometry (GC-MS) to find the different phytocompounds in the ethanol leaf extract. Phytochemicals were determined using molecular weights (m/z) obtained from GC-MS chromatograms. Phytocompounds were identified using NIST library databases and spectral peak interpretation. Results: The phytochemical analysis found flavonoids, steroids, tannins, phenols, and glycosides. B. ovalifoliolata leaf extract included 28 phytochemical substances by GC-MS. The ethanol extract contained three major bioactive compounds: 1,2,3-Benzenetriol (36.16%), Quinic acid (21.84%), and Lupeol (11.75%), as well as eight minor compounds: Levoglucosan (3.53%), Hexadecanoicacid, Methylester (1.59%), n-Hexadecanoicacid (3.29%), Ethylester (1.64%), and Methyl-linolenate (1.30%). Bioactive substances are detected by retention duration, peak area, molecular formula, and likelihood. Conclusion: The findings suggest that B. ovalifoliolata may possess several beneficial properties, including as anti-cancer, antiulcer, antioxidant, anti-microbial, anti-diabetic, hepatoprotective, and hypocholesterolemic activities. Major Findings: Identification of key bioactive compounds, including flavonoids, steroids, tannins, phenols, and glycosides, in the ethanol extract of Boswellia ovalifoliolata leaves. GC-MS analysis revealed volatile and semi-volatile compounds, such as essential oils and secondary metabolites, with anti-inflammatory, antimicrobial, and antioxidant properties.
  • The Biology of Cancer: Understanding the Disease and Its Challenges
    Garla Venkateswarlu, Sachin Kumar, Suddikattu Bhargavi, Ramesh Bodla
    Biosensors and Aptamers A New Era in Cancer Diagnosis and Treatment, 2025
  • Nanomedicine research, development, and current clinical status
    Molakpogu Ravindra Babu, Shaik Abdul Rahaman, Garla Venkateswarlu, Yachana Mishra, Vijay Mishra
    Intelligent Nanobiosystems in Medicine and Healthcare Volume 1 Fundamentals Fabrication and Commercialization, 2025
  • Contemporary Developments in PROTACs for Cancer Management: An In-Depth Review
    Shaik Abdul Rahaman, Garla Venkateswarlu, Sakshi Patel, Prem Shankar Mishra, Rahul Kumar, Nayyar Parvez
    Current Topics in Medicinal Chemistry, 2025
    Proteolysis-Targeting Chimeras (PROTACs) represent a novel and promising cancer treatment strategy considered a direct alternative to conventional small-molecule inhibitors. PROTACs selectively degrade disease-causing proteins (including previously 'undruggable' targets such as transcription factors and scaffolding proteins) by harnessing the cellular ubiquitin proteasome system. In this review, we look at the most recent developments in PROTAC technology and their oncology applications. Versatility, while maintaining substrate selectivity and degradation efficiency, has also been enhanced by the expanded range of E3 ligases used in PROTAC design. Improvements in the stability, bioavailability, and systemic delivery of PROTACs are being achieved through innovations in pharmacokinetics and cell permeability, enabling their clinical translations. Initial clinical trials have confirmed the potential of these agents in human patients, and early preclinical studies have shown them to be highly efficacious in models of solid tumors and hematologic malignancies. Despite these encouraging developments, crucial challenges remain, including reducing off-target effects, addressing resistance mechanisms, and clarifying the significance of PROTAC-mediated degradation pathways. Future efforts must focus on refining the selectivity and tunability of degrader compounds, enhancing treatment efficacy via combination therapies, and optimizing PROTAC design through computational and structural biology. As the field continues to evolve, PROTACs remain a highly promising strategy for addressing unmet clinical needs in oncology. In this review, recent advancements in PROTAC technology are discussed, along with its contribution to cancer therapy and ways to circumvent existing challenges to its full therapeutic potential.
  • Modern industrial perspective of nanobiosystems
    Molakpogu Ravindra Babu, Yachana Mishra, Shaik Abdul Rahaman, Prathap Madeswara Guptha, Garla Venkateswarlu, Manoj Gadewar, Suddikattu Bhargavi
    Intelligent Nanobiosystems in Medicine and Healthcare Volume 1 Fundamentals Fabrication and Commercialization, 2025
  • Exploring the Efficacy of Traditional Herbs in Combating COVID-19: A Comprehensive Review
    Anil Sao, Tulsidas Nimbekar, Garla Venkateswarlu, Mohit Mishra, Aditya Kate, Meenakshi Kanwar Chauhan, Chandrashekhar Mahadeo Chakole
    Coronaviruses, 2024
    Background: The entire world witnessed the COVID-19 pandemic outbreak. It has become deadly everywhere across the globe. COVID-19 mortality varies across age groups and has been linked to an individual's innate immunity. In contrast, it was more lethal in immunocompromised people. The spread of viruses is slowed by both passive immunity and vaccine-aided acquired immunity. However, vaccine-induced immunity is transient, and there is no assurance that vaccinemediated antibodies will be effective against all future virus mutants. As a result, natural immunity boosters have become essential supplements that must be used nowadays to stay immunized against such infections. In Ayurvedic medicine, traditional Indian spices have been used for a long time to boost the immune system and fight off different diseases. Objective: This review aims to disseminate information about traditional natural medicine in repurposing as an immunity booster and for antiviral effects in COVID-19. Methods: Using published articles from recent years, the in silico docking study, survey-based study, and in vitro and preclinical research work on selected traditional herbs for their anti-inflammatory, immunomodulating, and antiviral properties are summarized. Withania somnifera, Piper nigrum, Emblica officinalis, Andrographis paniculate, Glycyrrhiza glabra, Ocimum sanctum, Piper longum, and Curcuma longa are some of the most commonly used natural spices studied extensively and hence selected in this review. Results: This context summarizes selected plants showing immunomodulatory and antiviral effects in experimental animals, simulation, and clinical studies. Conclusion: By virtue of antiviral potential, the chosen herbs could be used for repurposing in COVID-19 management after thorough clinical investigations.