Tetiana Bondarchuk

@new.meduniv.lviv.ua

biochrmistry
Danylo Halytsky Lviv National Medical University

Tetiana Bondarchuk


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https://researchid.co/tetianabondarchuk

RESEARCH, TEACHING, or OTHER INTERESTS

Biochemistry, Biochemistry (medical), Biochemistry, Genetics and Molecular Biology, Gastroenterology
8

Scopus Publications

63

Scholar Citations

3

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • Anti-inflammatory hydrogen sulfide-releasing agents with reduced gastro- And enterotoxicity on the stress model in rats
    Iryna FOMENKO, Iryna LOZYNSKA, Tetyana BONDARCHUK, Natalia DENYSENKO, Roman LESYK, et al.
    Minerva Biotechnology and Biomolecular Research, 2021
  • Changes of nitric oxide system and lipid peroxidation parameters in the digestive system of rats under conditions of acute stress, and use of nonsteroidal anti-inflammatory drugs
    Iryna Fomenko, Tetyana Bondarchuk, Vitaliy Emelyanenko, Natalia Denysenko, Sklyarov Pavlo, et al.
    Current Issues in Pharmacy and Medical Sciences, 2015
    The use of nonsteroidal anti-inflammatory drugs (NSAIDs) in combination with being physiologically stressed often occurs in in the course of different pathologies. This situation may result in the alteration of digestive system functioning. The effect of stress brings about changes in the activity of nitric oxide synthase (NOS), arginase, cyclooxygenase (COX) and lipid peroxidation, whereas the use of NSAIDs interrupts the multiple functions of the cell via the inhibition of prostaglandins (PGs) synthesis. Taking into account that NOS and COX-systems are connected in their regulation, the aim of the study was to determine the role played by NOS and lipid peroxidation under conditions of the combined action of NSAIDs and stress. In our study, male rats were used. The NSAIDs (naproxen - a non-selective COX inhibitor, celecoxib - a selective COX-2 blocker, and the compound 2A5DHT (which is the active substance of dual COX, and the lipoxygenase (LOX) inhibitor, darbufelone) were all administered at a dose 10 mg/kg, prior to water restraint stress (WRS). WRS brought about an increase of inducible NOS (iNOS) activity in the intestinal mucosal and muscular membranes, as well as in the pancreas. Because of this, constitutive NOS izoform (cNOS) and arginase activities decreased. Moreover, the MDA concentration increased, indicating the development of oxidative stress. In our work, pretreatment with naproxen, as in the WRS model, engendered a decrease in iNOS activity. What is more, administration of Celecoxib did not change iNOS activity, as compared to WRS alone, and it showed a tendency to reduce lipid peroxidation. In addition, 2A5DHT prior WRS brought about a decrease of iNOS activity, with the subsequent rise of cNOS activity. Of note, MDA concentration decreased in all studied organs, indicating the reduction of lipid peroxidation under the action of the darbufelone active substance.
  • Effects of conventional and hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs in rats with stress-induced and epinephrine-induced gastric damage
    Iryna Fomenko, Alexander Sklyarov, Tetyana Bondarchuk, Lilya Biletska, Natalia Panasyuk, et al.
    Stress, 2014
    Mechanisms of gastric defence under conditions of combined influence of acute stress and non-steroidal anti-inflammatory drugs (NSAIDs) are still poorly studied. The aim of this study was to explore the effects of different types of NSAIDs (naproxen, celecoxib and ATB-346) in producing experimental gastric lesions (induced by water-restraint stress (WRS) or by epinephrine (EPN) injection) and to determine the role of lipid peroxidation and the nitric oxide (NO) system in the pathogenesis of the damage. Male rats were used (eight per group) in this work. The NSAIDs were all administered at a dose 10 mg kg−1 30 min prior to WRS or EPN injection. Administration of naproxen to the control rats caused development of gastric lesions, whereas administration of a hydrogen sulfide (H2S)-releasing NSAID (ATB-346) or a selective cyclooxygenase-2 inhibitor (celecoxib) did not cause gastric damage. In contrast, lipid peroxidation processes were enhanced in all groups as was the activity of NO synthase (NOS). Pretreatment with naproxen in the WRS model caused an increase in severity of damage and a decrease in NOS activity. ATB-346 displayed beneficial effects, manifested by a decrease in the area of gastric damage, but parameters of lipid peroxidation and the NOS system did not differ substantially from those in the group treated with naproxen. Administration of different NSAIDs under conditions of EPN-induced gastric damage resulted in the decrease in NOS activity and lipid peroxidation. None of the tested NSAIDs exacerbated EPN-induced gastric mucosal injury; indeed, they all reduced the extent of damage.
  • [Parameters of NO synthase system of gastric mucosa in rats under stress conditions and inhibition of cyclooxygenase].
    IS Fomenko, TI Bondarchuk, LP Bilets'ka, NB Panasiuk, OIa Skliarov, et al.
    Fiziolohichny Zhurnal Kiev Ukraine 1994, 2014
    In experiments on rats with modeled water-restrained stress, the influence of nonsteroidal anti-inflammatory drugs of different genesis on morphological status of gastric mucosa and changes of NO-synthase system parameters have been studied Administration of nonselective cyclooxygenese inhibitor naproxen in the water-restrained stress model in rats potentiated the increase of severity of damage of gastric mucosa. At the same time, the activity of both inducible and constitutive isoforms ofNO-sythase decreased. The parameters of lipoperoxidation remained at the level observed during water-restrained stress. It was shown the advantages of the use of H2S-releasinfg nonsteroidal anti-inflammatory drug ATB-346, which are associated with its cytoprotective effect of the drug manifested by a decreased total area of gastric damage. However, parameters of lipoperoxidation and NO-syntase system did not differ substantially from those in the group treated with napoxen, indicating the prevalence of parent molecule (naproxen) in regulation of function of NO-system Administration of dual COX/LOX inhibitor, the compound 2A5DHT, caused a decrease of gastric damage as compared to the effect ofnaproxen. The activity of iNOS remained much higher than under condition of the naproxen action.
  • Dopamine receptor type 1 of Caenorhabditis elegans expressing in mechanosensory neurons
    V. V. Stadnyk, A. Regosh, C. Y. Mayor, I. S. Fomenko, T. I. Bondarchuk, et al.
    Biopolymers and Cell, 2012
    Until now the results on profiling dopamine receptors in C. elegans have been incomplete and fragmentary. The aim of this study was to investigate the expression profile of dop-1 gene in C. elegans using 3 kb promoter with 3'-end locating before ATG of dop-1gene. Methods. The strain of C. elegans with mutant unc-119 gene was used. To check a pattern of the dop-1 expression, the promoter of this gene was amplified using PCR. The animals were co-bombarded with plasmid pPD95.77 dop-1::GFP and reporter construct containing unc-119 gene. Results. Using GFP as a reporter protein, we built a whole picture of expression of dopamine receptor type 1 in C. elegans and found that this protein could be detected only in mechanosensory neurons such as PLM, PVQR, PVQL, ALNR, ALNL, DVAR, DVC.
  • Dual acting COX/LOX nonsteroidal anti-inflammatory drugs versus traditional COX-2 inhibitors
    Annales Universitatis Mariae Curie Sklodowska Sectio Ddd Pharmacia, 2010
  • The effect of COX-2 inhibitor celecoxib and proton pump blocker lansoprazole on lipoperoxidation processes in heart tissue and gastric mucosa of streptozotocin-induced diabetic in rats
    Annales Universitatis Mariae Curie Sklodowska Sectio Ddd Pharmacia, 2009
  • Combined effects of neurotransmitters upon secretory function of the rat stomach at different functional states of the gastric mucosa
    A. Yu. Sklyarov, A. M. Maslyanko, T. I. Bondarchuk
    Neurophysiology, 1999

RECENT SCHOLAR PUBLICATIONS

  • NEW INSIGHTS INTO THE ROLE OF VITAMIN D IN THE DEVELOPMENT OF CERTAIN PATHOLOGICAL PROCESSES
    IS FOMENKO, TI BONDARCHUK, TA ALYOKHINA
    ЕКСПЕРИМЕНТАЛЬНА ТА КЛІНІЧНА ФІЗІОЛОГІЯ І БІОХІМІЯ 3, 41-52 , 2025
    2025
  • [PDF] з домену dmed.org.ua Гідроген сульфід: біологічні та патохімічні ефекти
    ТІБІС ФОМЕНКО
    ЕКСПЕРИМЕНТАЛЬНА ТА КЛІНІЧНА ФІЗІОЛОГІЯ І БІОХІМІЯ» “EXPERIMENTAL AND … , 2024
    2024
  • Fomenko Iryna Особливості застосування інтерактивних форм навчання при вивченні біохімії у Львівському національному медичному університеті імені Данила Галицького за умов …
    ТІБІС ФОМЕНКО
    ЕКСПЕРИМЕНТАЛЬНА ТА КЛІНІЧНА ФІЗІОЛОГІЯ І БІОХІМІЯ» “EXPERIMENTAL AND … , 2022
    2022
  • Anti-inflammatory hydrogen sulfide-releasing agents with reduced gastro-and enterotoxicity on the stress model in rats.
    I Fomenko, I Lozynska, T Bondarchuk, N Denysenko, R Lesyk, A Sklyarov
    Minerva Biotechnology & Biomolecular Research 33 (2) , 2021
    2021
    Citations: 4
  • Minerva Biotechnology and Biomolecular Research 2021 June; 33 (2): 117-24
    I FOMENKO, I LOZYNSKA, T BONDARCHUK, N DENYSENKO, R LESYK, ...
    Minerva 33 , 2021
    2021
  • ІТРОЗО-ОКСИДАТИВНІ ПРОЦЕСИ В ОРГАНАХ ТРАВНОЇ СИСТЕМИ ПРИ ДІЇ L-АРГІНІНУ ТА АМІНОГУАНІДИНУ ЗА УМОВ ЕКСПЕРИМЕНТАЛЬНОГО ЦУКРОВОГО ДІАБЕТУ
    НВД О.Я. Скляров О.І. Децик , О.Б. Панчишин , І.С. Фоменко , Т.І. Бондарчук ...
    Art of Medicine 18 (2), 44-49 , 2021
    2021
  • Цитопротекторний вплив NO, Н2S та системи циклооксигеназа/простагландини в слизовій оболонці товстої кишки щурів при виразковому коліті
    ОЯС ІС Фоменко, ТІ Бондарчук, АС Юет
    Physiological Journal/Fiziologichnyi Zhurnal 66 (5) , 2020
    2020
  • INVESTIGATION OF THE INFLUENCE OF HYDROGEN SULFIDE DONORS ON THE LEVEL OF OXIDATIVE STRESS UNDER CONDITION OF ACUTE PANCREATITIS IN RATS
    TI BONDARCHUK, IS FOMENKO
    ВЕСТНИК ПРОБЛЕМ БИОЛОГИИ И МЕДИЦИНЫ 1 (1), 98 , 2020
    2020
  • Дослідження впливу донорів гідрогену сульфіду на ступінь оксидативного стресу при експериментальному гострому панкреатиті у щурів.
    ТІБІС ФОМЕНКО
    Вісник біології та медицини 155, 98-102 , 2020
    2020
  • Changes of nitric oxide system and lipid peroxidation parameters in the digestive system of rats under conditions of acute stress, and use of nonsteroidal anti-inflammatory drugs
    I Fomenko, T Bondarchuk, V Emelyanenko, N Denysenko, S Pavlo, I Ilkiv, ...
    Current Issues in Pharmacy and Medical Sciences 28 (1), 37-41 , 2015
    2015
    Citations: 16
  • Peculiarities of Effects of Nonsteroidal Anti-inflammatory Drugs on NO-synthase System in Gastric Mucosa of Rats under Stress Conditions
    IS Fomenko, TI Bondarchuk, LP Biletska, NB Panasyuk, OY Sklyarov
    International Journal of Physiology and Pathophysiology 6 (4) , 2015
    2015
  • Effects of conventional and hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs in rats with stress-induced and epinephrine-induced gastric damage
    I Fomenko, A Sklyarov, T Bondarchuk, L Biletska, N Panasyuk, JL Wallace
    Stress 17 (6), 528-537 , 2014
    2014
    Citations: 36
  • Action of Different NSAIDs on Parameters of NO-Synthase System in Pancreas of Rats Under Condition of Water Immersion Restrain Stress
    TI Bondarchuk, IS Fomenko, LP Biletska, NB Panasyuk, AY Sklyarov
    DIGESTIVE DISEASES AND SCIENCES 59 (8), 1649-1649 , 2014
    2014
  • Pecularities of the Changes of NO-Synthase/Arginase System in Digestive Organs Under The Conditions of Stress and COX-1/COX-2, COX-2/5-LOX Blockage
    IS Fomenko, NB Panasyuk, II Ilkiv, TI Bondarchuk, PA Sklyarov, ...
    DIGESTIVE DISEASES AND SCIENCES 59 (8), 1654-1654 , 2014
    2014
  • Вплив вітамінів С та Е на процеси ліпопероксидації та активність NO-синтазної системи в підшлунковій залозі щурів на тлі адреналін-індукованого стресу
    TI Bondarchuk
    Буковинський медичний вісник 18 (2 (70)) , 2014
    2014
  • Parameters of NO synthase system of gastric mucosa in rats under stress conditions and inhibition of cyclooxygenase
    IS Fomenko, TI Bondarchuk, LP Bilets' ka, NB Panasiuk, OI Skliarov
    Fiziolohichnyi zhurnal (Kiev, Ukraine: 1994) 60 (2), 51-56 , 2014
    2014
    Citations: 1
  • INFLUENCE OF VITAMINS C AND E ON LIPID PEROXIDATION PROCESSES AND THE ACTIVITY OF NO-SYNTHASE SYSTEM IN PANCREAS OF RATS WITH THE EPINEPHRINE-INDUCED STRESS
    TI Bondarchuk
    ДОСЯГНЕННЯ ЦІЛЬОВОГО РІВНЯ АРТЕРІАЛЬНОГО ТИСКУ У ХВОРИХ НА АРТЕРІАЛЬНУ … , 2014
    2014
  • Ген дофамінового рецептора першого типу експресується в механосенсорних нейронах Caenorhabditis elegans
    ВВ Стадник, А Регош, ХЯ Майор, ІС Фоменко, ТІ Бондарчук, ...
    Biopolymers & Cell 28 (1), 75 , 2012
    2012
  • Dopamine receptor type 1 of Caenorhabditis elegans expressing in mechanosensory neurons
    VV Stadnyk, A Regosh, CY Mayor, IS Fomenko, TI Bondarchuk, ...
    Biopolymers and cell, 75-77 , 2012
    2012
  • Dual acting COX/LOX nonsteroidal anti-inflammatory drugs versus traditional COX-2 inhibitors
    I Fomenko, T Bondarchuk, A Sklyarov
    Current Issues in Pharmacy and Medical Sciences 23 (3), 197-202 , 2010
    2010
    Citations: 2

MOST CITED SCHOLAR PUBLICATIONS

  • Effects of conventional and hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs in rats with stress-induced and epinephrine-induced gastric damage
    I Fomenko, A Sklyarov, T Bondarchuk, L Biletska, N Panasyuk, JL Wallace
    Stress 17 (6), 528-537 , 2014
    2014
    Citations: 36
  • Changes of nitric oxide system and lipid peroxidation parameters in the digestive system of rats under conditions of acute stress, and use of nonsteroidal anti-inflammatory drugs
    I Fomenko, T Bondarchuk, V Emelyanenko, N Denysenko, S Pavlo, I Ilkiv, ...
    Current Issues in Pharmacy and Medical Sciences 28 (1), 37-41 , 2015
    2015
    Citations: 16
  • Anti-inflammatory hydrogen sulfide-releasing agents with reduced gastro-and enterotoxicity on the stress model in rats.
    I Fomenko, I Lozynska, T Bondarchuk, N Denysenko, R Lesyk, A Sklyarov
    Minerva Biotechnology & Biomolecular Research 33 (2) , 2021
    2021
    Citations: 4
  • Морфо-функціональні, метаболічні процеси та кровотік у слизовій оболонці шлунка при різних його функціональних станах
    ТІ Бондарчук
    ступеня канд. мед наук: 14.03. 03/ТІ Бондарчук , 2002
    2002
    Citations: 3
  • Dual acting COX/LOX nonsteroidal anti-inflammatory drugs versus traditional COX-2 inhibitors
    I Fomenko, T Bondarchuk, A Sklyarov
    Current Issues in Pharmacy and Medical Sciences 23 (3), 197-202 , 2010
    2010
    Citations: 2
  • Parameters of NO synthase system of gastric mucosa in rats under stress conditions and inhibition of cyclooxygenase
    IS Fomenko, TI Bondarchuk, LP Bilets' ka, NB Panasiuk, OI Skliarov
    Fiziolohichnyi zhurnal (Kiev, Ukraine: 1994) 60 (2), 51-56 , 2014
    2014
    Citations: 1
  • Combined effects of neurotransmitters upon secretory function of the rat stomach at different functional states of the gastric mucosa
    AY Sklyarov, AM Maslyanko, TI Bondarchuk
    Neurophysiology 31 (1), 56-58 , 1999
    1999
    Citations: 1
  • NEW INSIGHTS INTO THE ROLE OF VITAMIN D IN THE DEVELOPMENT OF CERTAIN PATHOLOGICAL PROCESSES
    IS FOMENKO, TI BONDARCHUK, TA ALYOKHINA
    ЕКСПЕРИМЕНТАЛЬНА ТА КЛІНІЧНА ФІЗІОЛОГІЯ І БІОХІМІЯ 3, 41-52 , 2025
    2025
  • [PDF] з домену dmed.org.ua Гідроген сульфід: біологічні та патохімічні ефекти
    ТІБІС ФОМЕНКО
    ЕКСПЕРИМЕНТАЛЬНА ТА КЛІНІЧНА ФІЗІОЛОГІЯ І БІОХІМІЯ» “EXPERIMENTAL AND … , 2024
    2024
  • Fomenko Iryna Особливості застосування інтерактивних форм навчання при вивченні біохімії у Львівському національному медичному університеті імені Данила Галицького за умов …
    ТІБІС ФОМЕНКО
    ЕКСПЕРИМЕНТАЛЬНА ТА КЛІНІЧНА ФІЗІОЛОГІЯ І БІОХІМІЯ» “EXPERIMENTAL AND … , 2022
    2022
  • Minerva Biotechnology and Biomolecular Research 2021 June; 33 (2): 117-24
    I FOMENKO, I LOZYNSKA, T BONDARCHUK, N DENYSENKO, R LESYK, ...
    Minerva 33 , 2021
    2021
  • ІТРОЗО-ОКСИДАТИВНІ ПРОЦЕСИ В ОРГАНАХ ТРАВНОЇ СИСТЕМИ ПРИ ДІЇ L-АРГІНІНУ ТА АМІНОГУАНІДИНУ ЗА УМОВ ЕКСПЕРИМЕНТАЛЬНОГО ЦУКРОВОГО ДІАБЕТУ
    НВД О.Я. Скляров О.І. Децик , О.Б. Панчишин , І.С. Фоменко , Т.І. Бондарчук ...
    Art of Medicine 18 (2), 44-49 , 2021
    2021
  • Цитопротекторний вплив NO, Н2S та системи циклооксигеназа/простагландини в слизовій оболонці товстої кишки щурів при виразковому коліті
    ОЯС ІС Фоменко, ТІ Бондарчук, АС Юет
    Physiological Journal/Fiziologichnyi Zhurnal 66 (5) , 2020
    2020
  • INVESTIGATION OF THE INFLUENCE OF HYDROGEN SULFIDE DONORS ON THE LEVEL OF OXIDATIVE STRESS UNDER CONDITION OF ACUTE PANCREATITIS IN RATS
    TI BONDARCHUK, IS FOMENKO
    ВЕСТНИК ПРОБЛЕМ БИОЛОГИИ И МЕДИЦИНЫ 1 (1), 98 , 2020
    2020
  • Дослідження впливу донорів гідрогену сульфіду на ступінь оксидативного стресу при експериментальному гострому панкреатиті у щурів.
    ТІБІС ФОМЕНКО
    Вісник біології та медицини 155, 98-102 , 2020
    2020
  • Peculiarities of Effects of Nonsteroidal Anti-inflammatory Drugs on NO-synthase System in Gastric Mucosa of Rats under Stress Conditions
    IS Fomenko, TI Bondarchuk, LP Biletska, NB Panasyuk, OY Sklyarov
    International Journal of Physiology and Pathophysiology 6 (4) , 2015
    2015
  • Action of Different NSAIDs on Parameters of NO-Synthase System in Pancreas of Rats Under Condition of Water Immersion Restrain Stress
    TI Bondarchuk, IS Fomenko, LP Biletska, NB Panasyuk, AY Sklyarov
    DIGESTIVE DISEASES AND SCIENCES 59 (8), 1649-1649 , 2014
    2014
  • Pecularities of the Changes of NO-Synthase/Arginase System in Digestive Organs Under The Conditions of Stress and COX-1/COX-2, COX-2/5-LOX Blockage
    IS Fomenko, NB Panasyuk, II Ilkiv, TI Bondarchuk, PA Sklyarov, ...
    DIGESTIVE DISEASES AND SCIENCES 59 (8), 1654-1654 , 2014
    2014
  • Вплив вітамінів С та Е на процеси ліпопероксидації та активність NO-синтазної системи в підшлунковій залозі щурів на тлі адреналін-індукованого стресу
    TI Bondarchuk
    Буковинський медичний вісник 18 (2 (70)) , 2014
    2014
  • INFLUENCE OF VITAMINS C AND E ON LIPID PEROXIDATION PROCESSES AND THE ACTIVITY OF NO-SYNTHASE SYSTEM IN PANCREAS OF RATS WITH THE EPINEPHRINE-INDUCED STRESS
    TI Bondarchuk
    ДОСЯГНЕННЯ ЦІЛЬОВОГО РІВНЯ АРТЕРІАЛЬНОГО ТИСКУ У ХВОРИХ НА АРТЕРІАЛЬНУ … , 2014
    2014