Senior researcher at the Oswaldo Cruz Foundation (Fiocruz), Brazil, working in the field of Molecular Genetics of Microorganisms. Her research focuses on antimicrobial resistance, microbial diversity, molecular epidemiology, and the interaction between mobile genetic elements, bacteriophages, and CRISPR/Cas systems, with an integrated One Health perspective. She has extensive experience in genomic and molecular approaches applied to bacterial pathogens of clinical, environmental, and animal origin, contributing to surveillance, epidemiological monitoring, and translational research in public health.
EDUCATION
She holds a degree in Biology from FAFIRE and earned her MSc (1996) and PhD (2001) in Genetics from the Federal University of Pernambuco (UFPE). She conducted research and specialized training in molecular marker–based microbial genetics at the University of Notre Dame and at the Centers for Disease Control and Prevention (CDC, USA). She completed a postdoctoral fellowship in Microbiology and Molecular Biology at Fiocruz (2001–2002). Her research focuses on Molecular Genetics of Microorganisms, with emphasis on microbial diversity, molecular epidemiology and phylogeny, mechanisms of pathogenicity, antimicrobial resistance, and CRISPR/Cas systems.
RESEARCH, TEACHING, or OTHER INTERESTS
Applied Microbiology and Biotechnology, Genetics, Biochemistry, Genetics and Molecular Biology, Molecular Biology
56
Scopus Publications
1413
Scholar Citations
23
Scholar h-index
39
Scholar i10-index
Scopus Publications
Molecular epidemiological study of Pseudomonas aeruginosa strains isolated from hospitals in Brazil by MLST and CRISPR/Cas system analysis Keyla Vitória Marques Xavier, Ana Carolina de Oliveira Luz, José Wilson Silva-Junior, Beatriz Souza Toscano de Melo, Marcus Vinícius de Aragão Batista, Adrianne Maria de Albuquerque Silva, Valdir de Queiroz Balbino, Tereza Cristina Leal-Balbino Molecular Genetics and Genomics, 2025 The CRISPR/Cas system defends bacteria and archaea against invasive pathogens, such as phages, establishing an immunological memory from this interaction. Pseudomonas aeruginosa, an opportunistic pathogen, represents a significant public health concern due to its multidrug resistance. This study conducted a molecular epidemiological analysis of clinical isolates of Pseudomonas aeruginosa in Brazil using multilocus sequence typing (MLST) and characterization of CRISPR/Cas system. Most P. aeruginosa isolates harbored the type I-F CRISPR/Cas system (83%), with a subset also exhibiting the type I-E system. Additionally, some isolates presented incomplete CRISPR/Cas systems in their secondary loci. Notably, the isolate Pae93 exhibited a genetic composition rich in phage-related proteins proximal to the orphan CRISPR locus. The identification and characterization of spacer sequences, including previously undocumented ones, revealed a remarkable diversity of predatory mobile genetic elements (MGEs) among the P. aeruginosa isolates studied. The spacer sequences were incorporated into the MGE library. Additionally, the study identified the existence of prophages and anti-CRISPR genes. Two new sequence types (STs 3383 and 3384) were identified and added to the PubMLST database. No discernible correlation was established between the observed STs and the previously delineated CRISPR genotypes. However, the CRISPR system remains valuable for elucidating specific interactions between microorganisms and MGEs. The Brazilian population of clinical P. aeruginosa isolates was shown to be genetically heterogeneous with a non-clonal distribution, as revealed by MLST analysis. The presence of high-risk clones, such as ST 244 and ST 235, underscores the importance of robust epidemiological surveillance and infection control strategies for P. aeruginosa, especially in healthcare settings. This study significantly contributes to the understanding of the molecular epidemiology of these isolates in Brazil.
Diversity and Role of Prophages in Pseudomonas aeruginosa: Resistance Genes and Bacterial Interactions Keyla Vitória Marques Xavier, Adrianne Maria de Albuquerque Silva, Ana Carolina de Oliveira Luz, Felipe Santana Caboclo da Silva, Beatriz Souza Toscano de Melo, João Luiz de Lemos Padilha Pitta, Tereza Cristina Leal-Balbino Genes, 2025 Pseudomonas aeruginosa is a major pathogen associated with hospital-acquired infections, and the spread of carbapenem-resistant isolates highlights the urgency of developing non-conventional therapies, such as phage therapy. For this alternative to be effective, understanding phage–host interactions is crucial for the selection of candidate phages and offers new insights into these dynamics. Background/Objectives: This study aimed to characterize prophage diversity in clinical P. aeruginosa genomes, assess the relationship between phages and the CRISPR/Cas system, and investigate the potential role of prophages in disseminating resistance genes. Methods: A total of 141 genomes from Brazilian hospitals were analyzed. Prophage detection was performed using VIBRANT, and in silico analyses were conducted to evaluate taxonomic diversity, the presence of resistance genes, phage life cycle, genomic distribution, and the presence of the CRISPR/Cas system. Results: A total of 841 viral sequences were identified by the VIBRANT tool, of which 498 were confirmed by CheckV, with a predominance of the class Caudoviricetes and high overall phage diversity. No statistically significant difference was observed in the number of prophages between isolates with and without CRISPR/Cas systems. Prophages carrying resistance genes such as rsmA, OXA-56, SPM-1, and others were detected in isolates harboring the type I-C CRISPR/Cas system. Additionally, prophages showed no preference for specific insertion sites along the bacterial genome. Conclusions: These findings provide evidence of a well-established phage–host relationship. The dual role of prophages—as vectors of antimicrobial resistance and as potential therapeutic agents—reflects their dynamic impact on bacterial communities and reinforces their importance in developing new strategies to combat antimicrobial resistance.
Assessment of MepA inhibition potential using thiadiazine derivatives through fluorometry, docking, and qPCR Ana Carolina Justino de Araújo, Priscilla Ramos Freitas, Isaac Moura Araújo, João Arthur de Oliveira Borges, Ray Silva Almeida, José Bezerra de Araújo-Neto, Cícera Datiane de Moraes Oliveira-Tintino, Igor José dos Santos Nascimento, João Xavier de Araújo-Júnior, Edeildo Ferreira da Silva-Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Helcio Silva dos Santos, Julia Mariana Assis da Silva, Tereza Cristina Leal Balbino, Irwin Rose de Alencar Menezes, Saulo Relison Tintino, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais Braga Gene Reports, 2025
Antimicrobial and cytotoxic effects of Lippia alba essential oil on multidrug-resistant Acinetobacter baumannii clinical isolates Caroline Ferreira de Santana, Isis Caroline da Silva Cirino, Larissa Isabela Oliveira de Souza, Marcia Vanusa da Silva, Daniela Maria do Amaral Ferraz Navarro, Júlio César Ribeiro de Oliveira Farias de Aguiar, Regina Celia Bressan de Queiroz Figueiredo, Ana Raquel Pereira da Silva, Clara Mariana Gonçalves Lima, Evandro G. da Silva, Henrique Douglas Melo Coutinho, Tereza Cristina Leal-Balbino South African Journal of Botany, 2024
Emergence and spread of resistant and biofilm-forming Acinetobacter baumannii in critically ill COVID-19 patients Rafael Thiago Pereira da Silva, Igor Vasconcelos Rocha, Tainara Fernandes Dantas, Jaqueline dos Santos Silva, Sérgio Dias da Costa Júnior, Ana Carolina de Oliveira Luz, Marcelo Moreno, Tereza Cristina Leal-Balbino, Ana Vitória Araújo Lima, Evandro G.da Silva, Henrique Douglas Melo Coutinho, Maria Betânia Melo de Oliveira Microbial Pathogenesis, 2024
The Combinatory Effects of Essential Oil from Lippia macrophylla on Multidrug Resistant Acinetobacter baumannii Clinical Isolates Isis Caroline da Silva Cirino, Caroline Ferreira de Santana, Igor Vasconcelos Rocha, Larissa Isabela Oliveira de Souza, Marcia Vanusa Silva, Regina Celia Bressan Queiroz de Figueiredo, Henrique D. M. Coutinho, Tereza Cristina Leal‐Balbino Chemistry and Biodiversity, 2024 To assess the antibacterial effectiveness of Lippia macrophylla essential oil (LMEO) against multidrug‐resistant Acinetobacter baumannii isolates, both as a standalone treatment and in combination with conventional antibiotics. LMEO demonstrated a significant inhibitory effect on the growth of A. baumannii, with a minimum inhibitory concentration (MIC) below 500 μg/mL. Notably, LMEO was capable of reversing the antibiotic resistance of clinical isolates or reducing their MIC values when used in combination with antibiotics, showing synergistic (FICI≤0.5) or additive effects. The combination of LMEO and imipenem was particularly effective, displaying synergistic interactions for most isolates. Ultrastructural analyses supported these findings, revealing that the combination of LMEO+ceftazidime compromised the membrane integrity of the Acb35 isolate, leading to cytoplasmic leakage and increased formation of Outer Membrane Vesicles (OMVs). Taken together our results point for the use of LMEO alone or in combination as an antibacterial agent against A. baumannii. These findings offer promising avenues for utilizing LMEO as a novel antibacterial strategy against drug‐resistant infections in healthcare settings, underscoring the potential of essential oils in enhancing antibiotic efficacy.
Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration Priscilla R. Freitas, Ana C.J. de Araújo, Isaac M. Araújo, Ray S. de Almeida, João A.O. Borges, Cícera L.R. Paulo, Cícera D.M. Oliveira-Tintino, Gustavo M. Miranda, José B. Araújo-Neto, Igor J.S. Nascimento, João X. Araújo-Júnior, Julia M.A. Silva, Tereza C.L. Balbino, Edeildo F. Silva-Júnior, Thiago M. Aquino, Francisco J.B. Mendonca-Junior, Emmanuel S. Marinho, Hélcio S. Santos, Clara Mariana Gonçalves Lima, Ahmad J. Obaidullah, Talha Bin Emran, Francisco A.B. Cunha, Irwin R.A. Menezes, Saulo R. Tintino, Henrique D.M. Coutinho Biomedicine and Pharmacotherapy, 2024 Staphylococcus aureus is a bacterium responsible for resistance to multiple drugs and the efflux system is widely studied among the resistance mechanisms developed by this species. The present study evaluates the inhibition of the MepA efflux pump by thiadiazine-derived compounds. For this purpose, thiadiazine-derived compounds (IJ-14 to IJ-20) were tested against S. aureus K2068 strains. Microdilution tests were initially conducted to assess the Minimum Inhibitory Concentration (MIC) of the compounds and their efflux pump inhibition activity. In addition, fluorimetry tests were performed using BrEt emission and tests were conducted to inhibit the expression of the mepA gene. This involved comparing the bacterial gene expression with the antibiotic alone to the gene expression after combining compounds (IJ-17 and IJ-20) with the antibiotic. Furthermore, membrane permeability assessment tests and in silico molecular docking tests were performed. It was observed that the IJ17 and IJ20 compounds exhibited direct activity against the tested strain. The IJ17 compound produced significant results in the gene inhibition tests, which was also evidenced through the membrane permeability alteration test. These findings suggest that thiadiazine-derived compounds have promising effects against one of the main resistance mechanisms, with the IJ17 compound presenting observable mechanisms of action.
Inhibition of the norA gene expression and the NorA efflux pump by the tannic acid Saulo Relison Tintino, Polrat Wilairatana, Veruska Cintia Alexandrino de Souza, Julia Mariana Assis da Silva, Pedro Silvino Pereira, Cícera Datiane de Morais Oliveira-Tintino, Yedda Maria Lobo Soares de Matos, João Tavares Calixto Júnior, Valdir de Queiroz Balbino, José P. Siqueira-Junior, Irwin Rose Alencar Menezes, Abolghasem Siyadatpanah, Henrique Douglas Melo Coutinho, Tereza Cristina Leal Balbino Scientific Reports, 2023
Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach Cristina Rodrigues dos Santos Barbosa, Débora Feitosa Muniz, Pedro Silvino Pereira, Sandrine Maria de Arruda Lima, Cícera Datiane de Morais Oliveira Tintino, Veruska Cintia Alexandrino de Souza, Julia Mariana Assis da Silva, Roger Henrique Sousa da Costa, Jacqueline Cosmo Andrade Pinheiro, Yedda Maria Lobo Soares de Matos, Irwin Rose Alencar Menezes, Teresinha Gonçalves da Silva, Gláucia Manoella de Souza Lima, Tereza Cristina Leal Balbino, José Pinto Siqueira-Júnior, Francisco Assis Bezerra da Cunha, Henrique Douglas Melo Coutinho, Saulo Relison Tintino Bioorganic and Medicinal Chemistry Letters, 2021
Chemical synthesis, molecular docking and MepA efflux pump inhibitory effect by 1,8-naphthyridines sulfonamides Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Débora Feitosa Muniz, Cristina Rodrigues dos Santos Barbosa, Raimundo Luiz Silva Pereira, Iêda Maria Begnini, Ricardo Andrade Rebelo, Luiz Everson da Silva, Sandro Lucio Mireski, Michele Caroline Nasato, Maria Isabel Lacowicz Krautler, Pedro Silvino Pereira, Tereza Cristina Leal Balbino, José Galberto Martins da Costa, Fabiola Fernandes Galvão Rodrigues, Alexandre Magno Rodrigues Teixeira, Humberto Medeiros Barreto, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Teresinha Gonçalves da Silva European Journal of Pharmaceutical Sciences, 2021
Effect of vitamin K3 inhibiting the function of nora efflux pump and its gene expression on staphylococcus aureus Saulo R. Tintino, Veruska C. A. de Souza, Julia M. A. da Silva, Cícera Datiane de M. Oliveira-Tintino, Pedro S. Pereira, Tereza C. Leal-Balbino, Antonio Pereira-Neves, José P. Siqueira-Junior, José G. M. da Costa, Fabíola F. G. Rodrigues, Irwin R. A. Menezes, Gabriel C. A. da Hora, Maria C. P. Lima, Henrique D. M. Coutinho, Valdir Q. Balbino Membranes, 2020
High frequency of OXA-253-producing Acinetobacter baumannii in different hospitals in Recife, Brazil Felipe Lira de Sá Cavalcanti, Carina Lucena Mendes-Marques, Crhisllane Rafaele dos Santos Vasconcelos, Túlio de Lima Campos, Antonio Mauro Rezende, Danilo Elias Xavier, Nilma Cintra Leal, Osvaldo Pompilio de-Melo-Neto, Marcia Maria Camargo de Morais, Tereza Cristina Leal-Balbino Antimicrobial Agents and Chemotherapy, 2017
Plague and tularemia Tereza Cristina Leal-Balbino, Maria Betânia Melo de Oliveira, Maria Paloma Silva de Barros, Marise Sobreira, Vladimir da Mota Silveira-Filho Arthropod Borne Diseases, 2016
Dynamics of CRISPR loci in microevolutionary process of yersinia pestis strains Maria Paloma S. Barros, Camila T. França, Rosanny Holanda F. B. Lins, Milena Danda V. Santos, Ednaldo J. Silva, Maria Betânia M. Oliveira, Vladimir M. Silveira-Filho, Antônio M. Rezende, Valdir Q. Balbino, Tereza Cristina Leal-Balbino Plos One, 2014
Plague in Brazil: From now and then Celso Tavares, Antônia Ivoneida Aragão, Nilma Cintra Leal, Tereza Cristina Leal-Balbino, Maria Betânia Melo de Oliveira, Geane Maria de Oliveira Gonçalves Ferreira, Alzira Maria Paiva de Almeida Advances in Experimental Medicine and Biology, 2012
Genetic diversity of yersinia pestis in Brazil M.B.M. Oliveira, M.P.S. Barros, V.M. Silveira-Filho, M.R. Araújo-Nepomuceno, V.Q. Balbino, N.C. Leal, A.M.P. Almeida, T.C. Leal-Balbino Genetics and Molecular Research, 2012
Detection of toxigenic genes in samples of Staphylococcus spp. isolated from rennet cheese Manuela Figueiroa Lyra de Freitas, Isabelle da Silva Luz, José Wilton Pinheiro Júnior, Dalila Angélica Moliterno Duarte, Ana Mercia Mendes Vasconcelos, Aldemir Reginato Ribeiro, Rinaldo Aparecido Mota, Tereza Cristina Leal Balbino, Tânia Lúcia Montenegro Stamford Ciencia E Tecnologia De Alimentos, 2009
Staphylococcal toxin genes in strains isolated from cows with subclinical mastitis Manuela F.L. de Freitas, Isabelle da S. Luz, Vladimir da M. Silveira-Filho, José W.P. Júnior, Tânia L.M. Stamford, Rinaldo A. Mota, Maria J. de Sena, Alzira M.P. de Almeida, Valdir de Q. Balbino, Tereza C. Leal-Balbino Pesquisa Veterinaria Brasileira, 2008
The pgm locus and pigmentation phenotype in Yersinia pestis Tereza Cristina Leal-Balbino, Nilma Cintra Leal, Mirna Gisele Medeiros do Nascimento, Maria Betânia Melo de Oliveira, Valdir de Queiroz Balbino, Alzira Maria Paiva de Almeida Genetics and Molecular Biology, 2006
Surveillance of plague in the State of Ceará: 1990-1999 Antônia Ivoneida Aragão, Antônio Carlos M. Seoane, Tereza Cristina Arcanjo Leal, Nilma Cintra Leal, Alzira Maria Paiva de Almeida Revista Da Sociedade Brasileira De Medicina Tropical, 2002
Molecular epidemiological study of Pseudomonas aeruginosa strains isolated from hospitals in Brazil by MLST and CRISPR/Cas system analysis KVM Xavier, AC de Oliveira Luz, JW Silva-Junior, BST de Melo, ... Molecular Genetics and Genomics 300 (1), 33 , 2025 2025 Citations: 12
Assessment of MepA inhibition potential using thiadiazine derivatives through fluorometry, docking, and qPCR ACJ de Araújo, PR Freitas, IM Araújo, JA de Oliveira Borges, RS Almeida, ... Gene Reports 39, 102162 , 2025 2025 Citations: 2
Diversity and Role of Prophages in Pseudomonas aeruginosa : Resistance Genes and Bacterial Interactions KVM Xavier, AMA Silva, ACO Luz, FSC Da Silva, BST de Melo, JLLP Pitta, ... Genes 16 (6), 656 , 2025 2025 Citations: 2
Antimicrobial and cytotoxic effects of Lippia alba essential oil on multidrug-resistant Acinetobacter baumannii clinical isolates CF de Santana, IC da Silva Cirino, LIO de Souza, MV da Silva, ... South African Journal of Botany 175, 479-485 , 2024 2024 Citations: 1
Emergence and spread of resistant and biofilm-forming Acinetobacter baumannii in critically ill COVID-19 patients RTP da Silva, IV Rocha, TF Dantas, J dos Santos Silva, ... Microbial pathogenesis 197, 107078 , 2024 2024 Citations: 7
The Combinatory Effects of Essential Oil from Lippia macrophylla on Multidrug Resistant Acinetobacter baumannii Clinical Isolates IC da Silva Cirino, CF de Santana, I Vasconcelos Rocha, LIO de Souza, ... Chemistry & Biodiversity 21 (10), e202400537 , 2024 2024 Citations: 2
Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration PR Freitas, ACJ de Araújo, IM Araújo, RS de Almeida, JAO Borges, ... Biomedicine & Pharmacotherapy 179, 117291 , 2024 2024 Citations: 9
Prevalence of cag A, cag M, vac A and oip A genes in isolates of Helicobacter pylori obtained from hospital patients in Northeast Brazil TMO Bezerra, KVM Xavier, ACO Luz, IMF Cavalcanti, CAA Brito, ... Brazilian Journal of Microbiology 55 (3), 2631-2641 , 2024 2024 Citations: 3
Comparison of genotyping methods and toxin gene profiles of Staphylococcus aureus isolates from clinical specimens M Andrade-Figueiredo, ACO Luz, V Mota Silveira Filho, TC Leal-Balbino Genetics and Molecular Biology 46 (4), e20220321 , 2023 2023 Citations: 5
Inhibition of the norA gene expression and the NorA efflux pump by the tannic acid SR Tintino, P Wilairatana, VCA de Souza, JMA da Silva, PS Pereira, ... Scientific reports 13 (1), 17394 , 2023 2023 Citations: 17
Comparative transcriptomics analysis of multidrug-resistant Acinetobacter baumannii in response to treatment with the terpenic compounds thymol and carvacrol IC da Silva Cirino, CF de Santana, MJR Bezerra, IV Rocha, ... Biomedicine & Pharmacotherapy 165, 115189 , 2023 2023 Citations: 19
Analysis of CRISPR/Cas Genetic Structure, Spacer Content and Molecular Epidemiology in Brazilian Acinetobacter baumannii Clinical Isolates AMA Silva, ACO Luz, KVM Xavier, MPS Barros, HB Alves, MVA Batista, ... Pathogens 12 (6), 764 , 2023 2023 Citations: 5
Analysis of CRISPR/Cas Genetic Structure, Spacer Content and Molecular Epidemiology in Brazilian Acinetobacter baumannii Clinical Isolates. Pathogens 2023, 12, 764 AMA Silva, ACO Luz, KVM Xavier, MPS Barros, HB Alves, MVA Batista, ... 2023
Incidence and dissemination of genes encoding Aminoglyco-side-Modifying Enzymes (AME's) in clinical isolates of Aci-netobacter baumannii and Pseudomonas aeruginosa in Recife … AVA Lima, SM Silva, AV Barbosa, MTS Correia, ACO Luz, TH Napoleão, ... 2023
Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach CR dos Santos Barbosa, DF Muniz, PS Pereira, SM de Arruda Lima, ... Bioorganic & medicinal chemistry letters 50, 128334 , 2021 2021 Citations: 6
Genetic characteristics and phylogenetic analysis of Brazilian clinical strains of Pseudomonas aeruginosa harboring CRISPR/Cas systems AC de Oliveira Luz, WJ da Silva Junior, JB do Nascimento Junior, ... Current genetics 67 (4), 663-672 , 2021 2021 Citations: 9
Resistance Genes SC Ramírez, M Hamidian, R Zarrilli, OP de-Melo-Neto, NC Leal, ... Genomic Basis of Antibiotic Resistance and Virulence in Acinetobacter, 1176661 , 2021 2021
Chemical synthesis, molecular docking and MepA efflux pump inhibitory effect by 1, 8-naphthyridines sulfonamides CD de Morais Oliveira-Tintino, SR Tintino, DF Muniz, ... European Journal of Pharmaceutical Sciences 160, 105753 , 2021 2021 Citations: 23
Epidemiologia molecular de Staphylococcus aureus no Brasil: elevada frequência de clones epidêmicos| pandêmicos, CA-MRSA e perspectivas futuras Molecular epidemiology of … SCG dos Santos, LN Baroni, MRAA Neta, TC Leal-Balbino, ... Brazilian Journal of Development 7 (4), 35734-35751 , 2021 2021 Citations: 2
Genetic and Biochemical Diversity of Clinical Acinetobacter baumannii and Pseudomonas aeruginosa Isolates in a Public Hospital in Brazil MDV Santos, MPS Barros, VM Silveira-Filho, CL Mendes-Marques, ... Microbial Drug Resistance 27 (4), 509-517 , 2021 2021 Citations: 4
MOST CITED SCHOLAR PUBLICATIONS
Evaluation of the tannic acid inhibitory effect against the NorA efflux pump of Staphylococcus aureus SR Tintino, CDM Oliveira-Tintino, FF Campina, RLP Silva, MS Costa, ... Microbial pathogenesis 97, 9-13 , 2016 2016 Citations: 127
Clonal diversity and epidemiological characteristics of Staphylococcus aureus: high prevalence of oxacillin-susceptible mec A-positive Staphylococcus aureus (OS-MRSA … M Andrade-Figueiredo, TC Leal-Balbino BMC microbiology 16 (1), 115 , 2016 2016 Citations: 77
Tannic acid affects the phenotype of Staphylococcus aureus resistant to tetracycline and erythromycin by inhibition of efflux pumps SR Tintino, CD Morais-Tintino, FF Campina, MS Costa, IRA Menezes, ... Bioorganic chemistry 74, 197-200 , 2017 2017 Citations: 67
Action of cholecalciferol and alpha-tocopherol on Staphylococcus aureus efflux pumps SR Tintino, CD Morais-Tintino, FF Campina, RL Pereira, M do S Costa, ... EXCLI journal 15, 315 , 2016 2016 Citations: 61
Evaluation of a RAPD‐based typing scheme in a molecular epidemiology study of Vibrio cholerae O1, Brazil NC Leal, M Sobreira, TC Leal‐Balbino, AMP De Almeida, MJB da Silva, ... Journal of applied microbiology 96 (3), 447-454 , 2004 2004 Citations: 58
Effect of Vitamin K 3 Inhibiting the Function of NorA Efflux Pump and Its Gene Expression on Staphylococcus aureus SR Tintino, VCA Souza, JMA Silva, CDM Oliveira-Tintino, PS Pereira, ... Membranes 10 (6), 130 , 2020 2020 Citations: 56
Typing of human and bovine Staphylococcus aureus by RAPD‐PCR and ribotyping‐PCR MSV Pereira, NC Leal, TCA Leal, M Sobreira, AMP De Almeida, ... Letters in applied microbiology 35 (1), 32-36 , 2002 2002 Citations: 55
Comparative Genomics of Acinetobacter baumannii Clinical Strains From Brazil Reveals Polyclonal Dissemination and Selective Exchange of Mobile Genetic … NC Leal, TL Campos, AM Rezende, C Docena, CL Mendes-Marques, ... Frontiers in Microbiology 11, 1176 , 2020 2020 Citations: 53
Genetic diversity and virulence potential of clinical and environmental Aeromonas spp. isolates from a diarrhea outbreak LCA Silva, TC Leal-Balbino, BST Melo, CL Mendes-Marques, ... BMC microbiology 17 (1), 179 , 2017 2017 Citations: 51
Antibiotic resistance and molecular analysis of Staphylococcus aureus isolated from cow's milk and dairy products in northeast Brazil VM Silveira-Filho, IS Luz, APF Campos, WM Silva, MPS Barros, ... Journal of food protection 77 (4), 583-591 , 2014 2014 Citations: 50
Mutational and acquired carbapenem resistance mechanisms in multidrug resistant Pseudomonas aeruginosa clinical isolates from Recife, Brazil FLS Cavalcanti, CR Mirones, ER Paucar, LÁ Montes, TC Leal-Balbino, ... Memórias do Instituto Oswaldo Cruz 110 (8), 1003-1009 , 2015 2015 Citations: 49
Vitamin K enhances the effect of antibiotics inhibiting the efflux pumps of Staphylococcus aureus strains SR Tintino, CDM Oliveira-Tintino, FF Campina, P Weslley Limaverde, ... Medicinal Chemistry Research 27 (1), 261-267 , 2018 2018 Citations: 47
Dynamics of CRISPR loci in microevolutionary process of Yersinia pestis strains MPS Barros, CT França, RHFB Lins, MDV Santos, EJ Silva, MBM Oliveira, ... PloS one 9 (9), e108353 , 2014 2014 Citations: 35
Phenotypic and genotypic variations among three allopatric populations of Lutzomyia umbratilis , main vector of Leishmania guyanensis MT de Souza Freitas, CM Ríos-Velasquez, CRL Costa Jr, ... Parasites & Vectors 8 (1), 448 , 2015 2015 Citations: 34
Cholesterol and ergosterol affect the activity of Staphylococcus aureus antibiotic efflux pumps SR Tintino, CDM Oliveira-Tintino, FF Campina, MS Costa, RP Cruz, ... Microbial pathogenesis 104, 133-136 , 2017 2017 Citations: 33
Occurrence and Diversity of Intra- and Interhospital Drug-Resistant and Biofilm-Forming Acinetobacter baumannii and Pseudomonas aeruginosa AV Araujo Lima, SM da Silva, JAA do Nascimento Júnior, MTS Correia, ... Microbial Drug Resistance 26 (7), 802-814 , 2020 2020 Citations: 29
Emergence of extensively drug-resistant OXA-72–producing Acinetobacter baumannii in Recife, Brazil: risk of clonal dissemination? FL de Sá Cavalcanti, ACS Almeida, MA Vilela, MA de Morais Junior, ... Diagnostic Microbiology and Infectious Disease 77 (3), 250-251 , 2013 2013 Citations: 29
Plague in Brazil: from now and then C Tavares, AI Aragão, NC Leal, TC Leal-Balbino, MBM de Oliveira, ... Advances in Yersinia research, 69-77 , 2012 2012 Citations: 29
Genetic structuring and fixed polymorphisms in the gene period among natural populations of Lutzomyia longipalpis in Brazil CR Lima Costa Jr, MTS Freitas, CA Santiago Figueirêdo Jr, NC Aragão, ... Parasites & vectors 8 (1), 193 , 2015 2015 Citations: 27
Differences in the stability of the plasmids of Yersinia pestis cultures in vitro: impact on virulence TC Leal-Balbino, NC Leal, CV Lopes, AMP de Almeida Memórias do Instituto Oswaldo Cruz 99, 727-732 , 2004 2004 Citations: 26