Sumana Ghosh

@srmist.edu.in

Research Assistant Professor in the Department of Mathematics
SRM Institute of Science and Technology

Sumana Ghosh


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https://researchid.co/sumana5588

RESEARCH, TEACHING, or OTHER INTERESTS

Mathematics, Applied Mathematics, Modeling and Simulation, Numerical Analysis
10

Scopus Publications

84

Scholar Citations

5

Scholar h-index

3

Scholar i10-index

Scopus Publications

  • Effect of media awareness in the spread of infectious diseases
    Sumana Ghosh, Jayanta Mondal, Subhas Khajanchi
    Journal of Applied Mathematics and Computing, 2025
  • Efficient electrokinetic non-Newtonian flow mixing in a patterned micro-tube
    Abhishek Banerjee, Sumana Ghosh, Bernhard Weigand
    Physics of Fluids, 2025
    This paper presents a numerical investigation of the micro-mixing behavior of a non-Newtonian fluid passing through a micro-tube with periodic zeta potential and sinusoidal wall roughness. A finite volume approach is utilized to numerically predict the flow field of two miscible aqueous electrolytes, which are described by a power-law model. To explore the pressure drop and mixing efficiency for a wide range of wave amplitude (δ), the Debye-H ü ckel parameter (κa), and the flow behavior index (n), simulations based on the Poisson-Nernst-Planck model are conducted. The presence of a sinusoidal charged surface is expected to increase the interfacial contact area between the two streams. With an increase in wall corrugation, the Debye length (λ), and the flow behavior index, a significant improvement in mixing efficiency is expected. Simulation results predict that the value of mixing efficiency rises up to 95% for δ=0.5, κa=10, and n=1.6. Moreover, for a thinner EDL, the mixing efficiency is predicted to reduce by 31% for a change in κa from 10 to 40 with n=1.5 and δ=0.5. It is also stated that increasing n, κa, and δ can result in a larger pressure drop in addition to forecasting a higher mixing. In order to create an effective and efficient micro-mixer that can forecast the highest possible mixing efficiency with a moderate pressure drop, a parametric study is conducted to predict and analyze the mixing performance factor, the ratio of mixing efficiency, and the average pressure drop. The findings of the current study could be useful for the thorough design and analysis of a passive micro-mixer, which would enable the effective transport of polymeric and bio-fluids inside micro-devices.
  • A mathematical model for tumor-immune competitive system with multiple time delays
    Mrinmoy Sardar, Subhas Khajanchi, Santosh Biswas, Sumana Ghosh
    Chaos Solitons and Fractals, 2024
  • Studying the role of random translocation of GLUT4 in cardiomyocytes on calcium oscillations
    Suvankar Halder, Phonindra Nath Das, Sumana Ghosh, Nandadulal Bairagi, Samrat Chatterjee
    Applied Mathematical Modelling, 2024
  • Understanding noise in cell signalling in the prospect of drug-targets
    Suvankar Halder, Sumana Ghosh, Joydev Chattopadhyay, Samrat Chatterjee
    Journal of Theoretical Biology, 2022
  • Delay induced interaction of humoral- and cell-mediated immune responses with cancer
    Sumana Ghosh, Sandip Banerjee
    Theory in Biosciences, 2022
  • Bistability in cell signalling and its significance in identifying potential drug-targets
    Suvankar Halder, Sumana Ghosh, Joydev Chattopadhyay, Samrat Chatterjee
    Bioinformatics, 2021
    Motivation Bistability is one of the salient dynamical features in various all-or-none kinds of decision-making processes. The presence of bistability in a cell signalling network plays a key role in input–output (I/O) relation. Our study is aiming to capture and emphasize the role of motif structure influencing the I/O relation between two nodes in the context of bistability. Here, a model-based analysis is made to investigate the critical conditions responsible for the emergence of different bistable protein–protein interaction (PPI) motifs and their possible applications to find the potential drug-targets. Results The global sensitivity analysis is used to identify sensitive parameters and their role in maintaining the bistability. Additionally, the bistable switching through hysteresis is explored to develop an understanding of the underlying mechanisms involved in the cell signalling processes, when significant motifs exhibiting bistability have emerged. Further, we elaborate the application of the results by the implication of the emerged PPI motifs to identify potential drug-targets in three cancer networks, which is validated with existing databases. The influence of stochastic perturbations that could hinder desired functionality of any signalling networks is also described here. Supplementary information Supplementary data are available at Bioinformatics online.
  • Understanding doxorubicin associated calcium remodeling during triple-negative breast cancer treatment: an in silico study
    Garhima Arora, Sumana Ghosh, Samrat Chatterjee
    Exploration of Targeted Anti Tumor Therapy, 2021
    Aim: Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer with high heterogeneity, rapid progression, and paucity of treatment options. The most effective chemotherapeutic drug used to treat TNBC is doxorubicin (Doxo) which is an anthracycline antibiotic. However, Doxo treatment alters cytosolic calcium dynamics leading to drug-resistance condition. The aim of this study is to capture the alterations in the activity of various calcium channels and pumps during Doxo treatment and their consequences on cytosolic calcium dynamics that ultimately result in drug resistance. Methods: In the present study, a mathematical model is proposed to capture the complex dynamical landscape of intracellular calcium during Doxo treatment. This study provides an insight into Doxo remodeling of calcium dynamics and associated drug-resistance effect. The model was first analyzed analytically and then explored through numerical simulation using techniques like global sensitivity analysis, parameter recalibration, etc. Results: The model is used to predict the potential combination therapy for Doxo that can overcome Doxo associated drug resistance. The results show targeting the dysregulated Ca2+ channels and pumps might provide efficient chemotherapy in TNBC. It was also observed that the indispensability of calcium influx rate is paramount in the Doxo drug resistance. Finally, three drugs were identified from existing literature that could be used as a combination therapy along with Doxo. Conclusions: The investigation highlights the importance of integrating the calcium signaling of various calcium regulating compounds for their effective anti-tumor effects deliverance along with chemotherapeutic agents. The results from this study might provide a new direction to the experimental biologists to explore different combination therapies with Doxo to enhance its anti-tumor effect.
  • Effects of Antibodies and Cytotoxic T-lymphocytes on Cancer: A Mathematical Study
    Sumana Ghosh, Sandip Banerjee
    International Journal of Applied and Computational Mathematics, 2020
  • Mathematical modeling of cancer–immune system, considering the role of antibodies
    Sumana Ghosh, Sandip Banerjee
    Theory in Biosciences, 2018

RECENT SCHOLAR PUBLICATIONS

  • Effect of media awareness in the spread of infectious diseases
    S Ghosh, J Mondal, S Khajanchi
    Journal of Applied Mathematics and Computing 71 (3), 3833-3860 , 2025
    2025
    Citations: 9
  • Efficient electrokinetic non-Newtonian flow mixing in a patterned micro-tube
    A Banerjee, S Ghosh, B Weigand
    Physics of Fluids 37 (3) , 2025
    2025
    Citations: 8
  • A mathematical model for tumor-immune competitive system with multiple time delays
    M Sardar, S Khajanchi, S Biswas, S Ghosh
    Chaos, Solitons & Fractals 179, 114397 , 2024
    2024
    Citations: 17
  • Studying the role of random translocation of glut4 in cardiomyocytes on calcium oscillations
    S Halder, PN Das, S Ghosh, N Bairagi, S Chatterjee
    Applied Mathematical Modelling 125, 599-616 , 2024
    2024
    Citations: 3
  • Understanding noise in cell signalling in the prospect of drug-targets
    S Halder, S Ghosh, J Chattopadhyay, S Chatterjee
    Journal of Theoretical Biology 555, 111298 , 2022
    2022
    Citations: 3
  • Delay induced interaction of humoral-and cell-mediated immune responses with cancer
    S Ghosh, S Banerjee
    Theory in Biosciences 141 (1), 27-40 , 2022
    2022
    Citations: 1
  • Bistability in cell signalling and its significance in identifying potential drug-targets
    S Halder, S Ghosh, J Chattopadhyay, S Chatterjee
    Bioinformatics 37 (22), 4156-4163 , 2021
    2021
    Citations: 11
  • Understanding doxorubicin associated calcium remodeling during triplenegative breast cancer treatment: an in silico study
    SC Garhima Arora, Sumana Ghosh
    Exploration of Targeted Anti-tumor Therapy 2, 208-226 https://doi.org/10 … , 2021
    2021
    Citations: 5
  • Effects of antibodies and cytotoxic T-lymphocytes on cancer: a mathematical study
    S Ghosh, S Banerjee
    International Journal of Applied and Computational Mathematics 6 (3), 60 , 2020
    2020
    Citations: 2
  • Mathematical modeling of cancer–immune system, considering the role of antibodies
    S Ghosh, S Banerjee
    Theory in Biosciences 137 (1), 67-78 , 2018
    2018
    Citations: 25

MOST CITED SCHOLAR PUBLICATIONS

  • Mathematical modeling of cancer–immune system, considering the role of antibodies
    S Ghosh, S Banerjee
    Theory in Biosciences 137 (1), 67-78 , 2018
    2018
    Citations: 25
  • A mathematical model for tumor-immune competitive system with multiple time delays
    M Sardar, S Khajanchi, S Biswas, S Ghosh
    Chaos, Solitons & Fractals 179, 114397 , 2024
    2024
    Citations: 17
  • Bistability in cell signalling and its significance in identifying potential drug-targets
    S Halder, S Ghosh, J Chattopadhyay, S Chatterjee
    Bioinformatics 37 (22), 4156-4163 , 2021
    2021
    Citations: 11
  • Effect of media awareness in the spread of infectious diseases
    S Ghosh, J Mondal, S Khajanchi
    Journal of Applied Mathematics and Computing 71 (3), 3833-3860 , 2025
    2025
    Citations: 9
  • Efficient electrokinetic non-Newtonian flow mixing in a patterned micro-tube
    A Banerjee, S Ghosh, B Weigand
    Physics of Fluids 37 (3) , 2025
    2025
    Citations: 8
  • Understanding doxorubicin associated calcium remodeling during triplenegative breast cancer treatment: an in silico study
    SC Garhima Arora, Sumana Ghosh
    Exploration of Targeted Anti-tumor Therapy 2, 208-226 https://doi.org/10 … , 2021
    2021
    Citations: 5
  • Studying the role of random translocation of glut4 in cardiomyocytes on calcium oscillations
    S Halder, PN Das, S Ghosh, N Bairagi, S Chatterjee
    Applied Mathematical Modelling 125, 599-616 , 2024
    2024
    Citations: 3
  • Understanding noise in cell signalling in the prospect of drug-targets
    S Halder, S Ghosh, J Chattopadhyay, S Chatterjee
    Journal of Theoretical Biology 555, 111298 , 2022
    2022
    Citations: 3
  • Effects of antibodies and cytotoxic T-lymphocytes on cancer: a mathematical study
    S Ghosh, S Banerjee
    International Journal of Applied and Computational Mathematics 6 (3), 60 , 2020
    2020
    Citations: 2
  • Delay induced interaction of humoral-and cell-mediated immune responses with cancer
    S Ghosh, S Banerjee
    Theory in Biosciences 141 (1), 27-40 , 2022
    2022
    Citations: 1