Stalin Antony

Scopus Publications

Photoprotective effects of deinoxanthin against UVA-Induced oxidative damage: an integrative computational and cellular analysis
Karankumar Balamurugan, Antony Stalin, Charan Singh Pawar, N. Rajendra Prasad
Archives of Dermatological Research, 2026
Musizin from Rhamnus wightii and Its Derivatives Attenuate Non-Alcoholic Fatty Liver Disease in Palmitate Oleate–Induced HepG2 Hepatocytes
Tharsius Raja William Raja, Antony Stalin, Veeramuthu Duraipandiyan, Kedike Balakrishna, Savarimuthu Ignacimuthu, A. Jennifer Christy, Michael Pillay
Revista Brasileira De Farmacognosia, 2026
The preference for ammonium may be attributed to a hyperpolarized membrane potential via TWIK-1 channels
Lanying Pan, Brendan Zhu, Simon L Vu, Antony Stalin, Ashley Winters, Qizhi Gong, Yuan Chen
Brain Research, 2026
Urine, which contains ammonium, transmits crucial signals among animals. However, the mechanism underlying signal transmission remains unknown. In our study, we observed that there are significant differences in olfactory preference depending on ammonium concentrations of 0.0004 %, 0.004 %, and 0.04 % between TWIK-1 gene knockout (TWIK-1 −/− ) and wild-type (WT) mice (p < 0.05, n = 6), although there is no significant preference difference between the 4 % concentration groups. These results are consistent with calcium imaging data, which showed an increase in calcium fluorescence only in the olfactory epithelium (OE) of TWIK-1 −/− mice at 4 and 400 µM NH 4 + concentrations, but in both groups at 40 mM NH 4 + . The electrophysiological results indicate an increase in the amplitudes of the inward current that hyperpolarizes the membrane potential at 400 µM NH 4 + , while it depolarizes the membrane potential at higher NH 4 + concentrations. These findings suggest a potential mechanism by which ammonium hyperpolarizes the membrane potential via TWIK-1 channels at low concentrations, making the OE cells more difficult to activate and resulting in the differences in olfactory preference between the two groups.
Editorial: Natural medicines for metabolic diseases – computational and pharmacological approaches, Volume II
Antony Stalin, Christudas Sunil, Abd El-Latif Hesham, Savarimuthu Ignacimuthu, Quan Zou, Yansu Wang
Frontiers in Pharmacology, 2026
(computational biopharmaceutics and modeling), Pharmaceutical Chemistry, Network Pharmacology Metabolic conditions, including type 2 diabetes mellitus (T2DM), obesity, dyslipidemia, and metabolic dysfunction associated with steatotic liver disease, together with their cardiovascular and renal complications, continue to rise in prevalence and impose a substantial economic burden worldwide. Current estimates indicate that more than 500 million individuals are affected by diabetes globally and is projected to increase markedly by 2045 (Sun et al., 2022). The multi-organ and multi-pathway dysregulation characteristic of these disorders leads to clinical heterogeneity, making it difficult to select treatment targets and resulting in mixed responses.Small molecules extracted from natural products and traditional medicines remain an important source of therapeutics, particularly for pathway-level modulation and rational polypharmacology (Newman and Cragg, 2020;Atanasov et al., 2021). In parallel, systems pharmacology, multi-omics technologies, and data-driven artificial intelligence (AI) methods are transforming the field by bridging phytochemicals, molecular targets, and disease phenotypes, enabling exploration of large chemical spaces and generation of experimentally testable mechanistic hypotheses (Hopkins, 2008;Vamathevan et al., 2019).Together, these advances provide a more tractable and mechanism-based framework for natural product research, from dataset construction and model development to candidate prioritization and biological validation.The Research Topic Natural Medicines for Metabolic Diseases: Computational and Pharmacological Approaches brings together contributions that integrate computational and experimental strategies to accelerate translation. It continues the editorial vision introduced in Volume I of this series (Stalin et al., 2024). Volume II comprises six papers: three original research articles and three review or meta-analytic studies, covering diabetic complications, target discovery, and methodology development. Cautious evidence synthesis also benefits clinical translation. Lin et al. conducted a systematic review and meta-analysis of Qingre Lishi decoction (QRLSD) for T2DM, summarizing data from 18 randomized controlled trials. The analysis reports improvements in fasting and postprandial glucose, HbA1c, lipid profiles, and indices of insulin resistance, without an apparent increase in adverse events. However, substantial heterogeneity among studies and variability in formulations limit the strength of causal inference. The authors appropriately call for large, multicenter trials using standardized preparations and extended follow-up to assess generalizability and long-term benefit.In Volume II, several priorities emerge for the next stage. First, improved data infrastructure is essential: standardized chemical identifiers, harmonized endpoints, curated databases, and transparent preprocessing pipelines are prerequisites for credible AI models and reproducible systems pharmacology. Second, multi-target design should be intentional rather than incidental; multi-objective optimization, uncertainty-aware prioritization, and explicit off-target risk assessment are necessary to balance efficacy, safety, and developability. Third, the most impactful studies will tightly integrate computation and experimentation, translating omics-derived hypotheses into a small number of high-confidence targets for directionality-aware testing and subjecting AIprioritized compounds to prospective evaluation, including early ADMET screening.Finally, openness should be the norm: shared code, datasets, and validation protocols will facilitate independent replication and rapid methodological iteration.Together, the six articles create a cohesive impact by supporting a realistic message: finding natural medicines to treat metabolic disorders is most effective when computational prioritization, inference of systems-level mechanisms, and pharmacological validation are integrated into a single auditable process. The Volume II collection is expected to help increase reproducible, mechanism-based pipelines and accelerate the development of promising natural products into plausible therapeutic candidates.
EnDeep4mC predicts DNA N4-methylcytosine sites using a dual-adaptive feature encoding framework in deep ensembles
Shuyu Zhang, Quan Zou, Mengting Niu, Zhibin Lv, Antony Stalin, Ximei Luo
Genome Research, 2026
DNA N 4 -methylcytosine (4mC), a key epigenetic modification regulating DNA repair and replication, requires efficient computational detection methods due to experimental limitations. Although machine learning predictors have been proposed, their performance could be enhanced through systematic optimization of feature encoding schemes. Here, we propose EnDeep4mC, a dual-adaptive framework integrating species-specific modeling with ensemble deep learning architectures to systematically optimize feature encoding schemes. Evaluated across six species, EnDeep4mC demonstrates commendable prediction performance and significantly outperforms current state-of-the-art predictors. Cross-species validation confirms its robust transferability from animal to microbe groups. Evolutionary analysis further uncovers the functional differentiation of 4mC sequences in biological evolution: Prokaryotic 4mC relies on stable patterns, whereas eukaryotes achieve regulatory plasticity through dynamic sequence combinations, which provides experimental evidence for species-adaptive encoding strategies.
Editorial: Novel natural therapies for infectious diseases using computational and pharmacological approaches
Antony Stalin, Pachaiyappan Saravana Kumar, Claudio Ferrante, Abd El-Latif Hesham, Savarimuthu Ignacimuthu, Ximei Luo
Frontiers in Pharmacology, 2026
(computational biopharmaceutics and modeling), Pharmaceutical Chemistry, Network Pharmacology Infectious diseases remain a persistent global public health challenge, driven by antimicrobial resistance (AMR) and the ongoing emergence of novel viral pathogens. Drugresistant bacteria were directly responsible for approximately 1.27 million deaths in 2019, with projections indicating a significant increase in this toll without new therapeutic interventions (Murray et al., 2022). Simultaneously, the rapid mutational dynamics of RNA viruses, including SARS-CoV-2 and influenza, continually generate immune-evasive and drug-resistant variants, necessitating broad-spectrum therapeutics (Dhama et al., 2023;Zhao et al., 2023). In this context, naturally derived products from plants, fungi, and marine organisms have re-emerged as historically validated sources of novel anti-infectives (Newman and Cragg, 2020). The pharmacological potential of natural products stems from their diverse secondary metabolites that target key viral and bacterial enzymes, including proteases, polymerases, and cell wall biosynthesis (Atanasov et al., 2021). The integration of computational methodologies such as molecular docking, MD simulations, machine learning, and network pharmacology with experimental pharmacology has catalyzed a paradigm shift in natural product-based drug discovery, enabling systematic virtual screening, ADMET profiling, and mechanistic hypothesis generation (Lluka and Stokes, 2022;Stalin et al., 2024;Wang et al., 2025).Within this context, the Research Topic "Novel Natural Therapies for Infectious Diseases Using Computational and Pharmacological Approaches" presents six articles, including four original research papers and two reviews, reflecting the breadth of contemporary natural antiinfective discovery.Zheng et al. present a review of traditional Chinese medicine in viral pneumonia, focusing on COVID-19-related mechanisms. Instead of viewing herbal medicine as a collection of remedies, the authors organize the literature by signaling pathways, including PI3K/Akt, NF-κB, JAK/STAT, and mTOR. This pathway-centered approach is valuable because it connects complex formulations to biological processes such as inflammation control, immune regulation, apoptosis, and tissue injury. The review also highlights a methodological direction for the field: natural therapies are more likely to achieve translational value when their effects are described in mechanistic terms that can be compared, tested, and refined. Their data show that plant extracts, especially ethyl acetate fractions, contain bioactive constituents and display measurable activity against bacterial and fungal pathogens; while docking and molecular dynamics simulations support plausible interactions with microbial targets. The strength of this work lies in its integrated workflow: metabolite characterization, biological testing, and in silico interpretation are used together rather than as isolated steps. This design increases the value of exploratory phytochemical studies by making the biological observations more interpretable.At the discovery-platform level, Narsing Rao et al. review omics strategies for obtaining molecules from marine Actinomycetota. The article highlights genome mining, metagenomics, transcriptomics, metabolomics, heterologous expression, and analytical methods as tools for overcoming a problem in natural product research: the repeated rediscovery of known compounds. Their review is relevant to this Research Topic because it expands the discussion from individual herbal interventions to the infrastructure needed for natural product discovery. In doing so, it reinforces a central message of the collection: progress in infectious disease pharmacology will increasingly depend on how well biological resources, computational methods, and validation strategies are integrated.The six articles demonstrate that the discovery of natural therapies for infectious diseases is shifting from single-technique, single-endpoint studies toward more integrated workflows.Several priorities emerge from this collection. First, natural products research in infectious disease requires stronger mechanistic resolution, so that extracts or compounds can be linked to defined pathways, host responses, or microbial targets. Second, computational tools should serve as decision-support systems that improve prioritization and reduce experimental ambiguity, rather than functioning as stand-alone additions. Third, model systems are important: clinically relevant ex vivo models, immune-aware infection models, and omics-guided microbial discovery platforms can enhance translational value. Finally, the field would benefit from improved standardization of phytochemical characterization, endpoint reporting, toxicity assessment, and data sharing, which are necessary for reproducibility and meaningful comparison across studies.Overall, this Research Topic provides a perspective on how natural therapies, when studied with pharmacological rigor and computational support, can contribute to anti-infective discovery. The collection does not claim that natural products will resolve the current burden of infectious disease. Instead, it presents a clearer argument: natural compounds, herbal formulations, and microbially derived metabolites remain therapeutic resources, and their future value will be greatest when discovery is guided by mechanism, informed by data, and validated in relevant systems.
Integrating bulk and single cell sequencing data to identify prognostic biomarkers and drug candidates in HBV associated hepatocellular carcinoma
Yanjie Zhong, Antony Stalin, Yu-Shi Dai, Zhiqiang He, Siqi Yang, et al.
Scientific Reports, 2025
Hepatitis B virus (HBV) infection is a major driver of hepatocellular carcinoma (HCC), yet the mechanisms by which HBV triggers HCC and how it interacts with the immune system remain largely undefined. In this study, 53 immune-related key genes involved in HBV-associated HCC progression were identified. By analyzing the mean C-index of 101 machine learning models, the optimal model-combining stepwise Cox regression (forward) with RSF-was developed to characterize the immune risk index. Patients in the high-risk group exhibited worse survival outcomes and increased infiltration of immunosuppressive cells. Integrating PPI analysis with machine learning, SPP1, GHR, and ESR1 emerged as promising druggable targets, with SPP1 notably overexpressed in tumors and linked to adverse outcomes. ScRNA-seq analysis revealed SPP1 was predominantly expressed in angio-TAMs, which may impair anti-tumor immunity by limiting T and NK cell infiltration. It also involved in tumor progression via angiogenesis and EMT pathways. Drug prediction and molecular docking identified small molecules such as myricetin and mefloquine that can target the aforementioned key immune genes, thereby modulating the immune landscape of HBV-HCC. Repurposing these established drugs represents a novel therapeutic avenue, offering both efficacy and expedited clinical translation for HBV-HCC.
hERG Channel Blockade and Antagonistic Interactions of Three Steroidal Alkaloids from Fritillaria Species
Hui Lu, Tingting Hao, Zixuan Zhang, Chenxin Jiang, Jianwei Xu, Antony Stalin, Wei Zhao
Molecules, 2025
The bulb of Fritillaria species called “Bei Mu” is a well-known traditional Chinese medicine. We have reported some potential off-target effects of “Bei Mu” due to peimine’s blockade of hERG (human Ether-a-go-go-Related Gene) channels. This research investigated the modulatory effects of three major alkaloid analogs of “Bei Mu” and their cooperative effects on hERG channels using manual whole-cell patch-clamp techniques. Results showed that peiminine and sipeimine blocked hERG currents with IC50s of 36.8 ± 2.5 μM and 47.6 ± 9.8 μM, which were close to that of peimine (26.1 ± 3.5 μM). Peiminine-induced blockade increased with increasing depolarizing strengths, durations, and frequencies, which suggested a preferential binding to open or inactivated states. The reduced blockade by the less inactivating S631A mutation supported peiminine‘s inactivation preference. Molecular docking and dynamics simulations confirmed the hERG-blocking activities of the three alkaloids and provided further insight into potential mechanisms. We also discovered antagonistic effects of the three alkaloids at nearly all concentrations tested, which might help reduce potential cardiotoxicities. To our knowledge, this is the first study to investigate combination effects of chemicals from one herb on hERG channels. In conclusion, peiminine and sipeimine can block hERG channels in a way similar to peimine, but antagonistic effects exist among them.
In silico molecular docking analysis on acetylcholinesterase (AChE) inhibition activity on Aedes aegypti and Culex quinquefasciatus by β-isocostic acid
Alex Yagoo, M.C. John Milton, Jelin Vilvest, Antony Stalin
Journal of Asia Pacific Entomology, 2025
Green synthesis of copper hydroxide nanorods using Solanum pubescens leaf extracts: a promising approach for antimicrobial, antioxidant, and anticancer applications
C. Neela Mohan, V. Ayyadurai, Karuppiah Nagaraj, P. Vijaya Kumar, K. Raja, P. Suganthi, C. Muthukumar, A. Stalin
3 Biotech, 2025
Identifying the DNA methylation preference of transcription factors using ProtBERT and SVM
Yanchao Li, Quan Zou, Qi Dai, Antony Stalin, Ximei Luo
Plos Computational Biology, 2025
Exploration of the regulatory mechanism of norcantharidin on sine oculis homeobox homolog 4 in colon cancer using transcriptome sequencing and bioinformatic
Fanqin Zhang, Chao Wu, Jingyuan Zhang, Zhihong Huang, Antony Stalin, Yiyan Zhai, Shuqi Liu, Jiarui Wu
Journal of Traditional Chinese Medical Sciences, 2025
Activity of Essential Oils From Pentanema indicum (L.) Y. Ling and Chromolaena odorata (L.) R.M.King & H. Rob Against Three Mosquito Species
Pathalam Ganesan, Jeyaraj Selvakumaran, Savarimuthu Ignacimuthu, Badr Aldahmash, Ahmed Rady, Fares Ahmed Alzahrani, Mansour Almansour, Antony Stalin
Entomological Research, 2025
Effects of host age and size on progeny production and different foods on the adult longevity of Spalangia nigroaenea Curtis (Hymenoptera: Pteromalidae) reared on puparia of Musca domestica L. (Diptera: Muscidae)
Narayanan Velayudham, Irrusappan Hari, Antony Stalin, Mukesh Kumar Dharmalingam Jothinathan, Rajakrishnan Rajagopal, Ahmed Alfarhan, Appadurai Daniel Reegan
Biocontrol Science and Technology, 2025
Enhanced Bioactivity of Streptomycin Bioconjugated Metal Nanoparticles Against Streptomycin Resistant Bacillus Sp
Nishanthi Ramasami, Manikandan Dhayalan, Malathi Selvaraj, Savaas Umar Mohammed Riyaz, Palani Perumal, Santiagu Stephen Irudayaraj, Rajakrishnan Rajagopal, Ahmed Alfarhan, Antony Stalin
Indian Journal of Microbiology, 2024
Anticancer effects of rutin from Fagopyrum tataricum (tartary buckwheat) against osteosarcoma cell line
Dennis Soosai, Ravindhran Ramalingam, Elumalai Perumal, Kaviarasan Veeramani, Charles Pancras, Mikhlid H. Almutairi, Leo Arockia Raj Savarimuthu, Duraipandiyan Veeramuthu, Stalin Antony
Molecular Biology Reports, 2024
Antimycobacterial activity of plant compounds against extensively drug resistant (XDR-TB) Mycobacterium tuberculosis
Duraipandiyan Veeramuthu, Ignacimuthu Savarimuthu, Inshad Ali Khan, Hissah Abdulrahman Alodaini, Ashraf Atef Hatamleh, Stalin Antony
Journal of King Saud University Science, 2024
Exploring the antiviral inhibitory activity of Niloticin against the NS2B/NS3 protease of Dengue virus (DENV2)
Antony Stalin, Jiajia Han, Appadurai Daniel Reegan, Savarimuthu Ignacimuthu, Shuwen Liu, Xingang Yao, Quan Zou
International Journal of Biological Macromolecules, 2024
Effectiveness of Bairui granules in the treatment of respiratory tract infections: A systematic review and meta-analysis
Keyan Chai, Haojia Wang, Yueqin Guan, Rui Shi, Antony Stalin, Yiyan Zhai, Jiying Zhou, Chuanqi Qiao, Siyun Yang, Jiaqi Li, Xiaomeng Zhang, Jiarui Wu
Medicine United States, 2024
Evaluation of mosquitocidal, histopathological and non-target effect of botanical pesticides from Stemodia viscosa and their mixtures against immature stages of Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus
Jeyaraj Selvakumaran, Kamaraj Ragavendran, Mariappan Muthukanagavel, Savarimuthu Ignacimuthu, Nayagam Vasanth, Rajapandiyan Krishnamoorthy, Mohammad Z. Ahmed, Ali S. Alqahtani, Antony Stalin, Pathalam Ganesan, Subramanian Mutheeswaran
Biologia, 2024
Potential inhibition of SARS-CoV-2 infection and its mutation with the novel geldanamycin analogue: Ignaciomycin
Antony Stalin, Pachaiyappan Saravana Kumar, Balakrishnan Senthamarai Kannan, Rajamanikam Saravanan, Savarimuthu Ignacimuthu, Quan Zou
Arabian Journal of Chemistry, 2024
Advances in functional lipid nanoparticles: from drug delivery platforms to clinical applications
Manikandan Dhayalan, Wei Wang, S. U. Mohammed Riyaz, Rakshi Anuja Dinesh, Jayashree Shanmugam, Santiagu Stephen Irudayaraj, Antony Stalin, Jayant Giri, Saurav Mallik, Ruifeng Hu
3 Biotech, 2024
Evaluating the Therapeutic Importance of Gold Nanoparticles Formed by the Biogenic Synthesis Route of Madhuca longifolia Reduction
Manikandan Dhayalan, Sheikdawood Parveen, Sathiyapriya Thirumalaisamy, Faruq Mohammad, Hamad A. Al-Lohedan, Savaas Umar Mohammed Riyaz, Rakshi Anuja Dinesh, Jayant Giri, Antony Stalin, Gangireddy Rajasekhar Reddy, Natarajan Anandakumar, Saurav Mallik
Bioresources, 2024
The anti-hepatocellular carcinoma effect of Aidi injection was related to the synergistic action of cantharidin, formononetin, and isofraxidin through BIRC5, FEN1, and EGFR
Shan Lu, Jiaqi Huang, Jingyuan Zhang, Chao Wu, Zhihong Huang, Xiaoyu Tao, Leiming You, Antony Stalin, Meilin Chen, Jiaqi Li, Yingying Tan, Zhishan Wu, Libo Geng, Zhiqi Li, Qiqi Fan, Pengyun Liu, Yifan Lin, Chongjun Zhao, Jiarui Wu
Journal of Ethnopharmacology, 2024
Corrigendum to “Integrated serum pharmacochemistry, 16S rRNA sequencing and metabolomics to reveal the material basis and mechanism of Yinzhihuang granule against non-alcoholic fatty liver disease” [J. Ethnopharmacol. 310 (2023) 116418] (Journal of Ethnopharmacology (2023) 310, (S0378874123002866), (10.1016/j.jep.2023.116418))
Yingying Tan, Zhihong Huang, Yingying Liu, Xiaojiaoyang Li, Antony Stalin, Xiaotian Fan, Zhishan Wu, Chao Wu, Shan Lu, Fanqin Zhang, Meilin Chen, Jiaqi Huang, Guoliang Cheng, Bing Li, Siyu Guo, Yu Yang, Shuofeng Zhang, Jiarui Wu
Journal of Ethnopharmacology, 2024
Editorial: Herbal medical products for metabolic diseases - new integrated pharmacological approaches
Antony Stalin, Abd El-Latif Hesham, Avdesh Mishra, Quan Zou, Savarimuthu Ignacimuthu
Frontiers in Pharmacology, 2024
Mosquitocidal efficacy of niloticin, isolated from Limonia acidissima L. (Rutaceae) against filarial vector Culex quinquefasciatus Say. (Diptera: Culicidae)
Appadurai Daniel Reegan, Antony Stalin, Munusamy Rajiv Gandhi, Santiagu Stephen Irudayaraj, Rajakrishnan Rajagopal, Ahmed Alfarhan
Toxin Reviews, 2024
Topical antifungal keratitis therapeutic potential of Clitoria ternatea Linn. flower extract: phytochemical profiling, in silico modelling, and in vitro biological activity assessment
Poomany Arul Soundara Rajan Yolin Angel, Palanisamy Jeyakumar, Arul Raj Jasmin Suriya, Aliyas Sheena, Ponmurugan Karuppiah, Govindasami Periyasami, Antony Stalin, Kasi Murugan
Frontiers in Microbiology, 2024
Investigating the Potential Mechanism of Huazhi Rougan Granules Against Alcoholic Liver Disease by Network Pharmacology and Experiment
Ying-Ying Tan, Ying-Ying Liu, Yi-Yan Zhai, Yi-Xuan Wang, Zhi-Shan Wu, Antony Stalin, Guo-Liang Cheng, Bing Li, Chao Wu, Zhi-Hong Huang, Shan Lu, Xiao-Tian Fan, Zheng Zhao, Jia-Rui Wu
World Journal of Traditional Chinese Medicine, 2024
Systematic review and meta-analysis on the efficacy and safety of Injectable Lentinan combined with chemotherapy in the treatment of gastric cancer
Yixuan Wang, Haojia Wang, Keyan Chai, Siyu Guo, Yiyan Zhai, Rui Shi, Fanqin Zhang, Jiaqi Huang, Zhengsen Jin, Yifei Gao, Xiaoyu Tao, Siyun Yang, Jiaqi Li, Jiying Zhou, Chuanqi Qiao, Antony Stalin, Jiarui Wu
Phytomedicine, 2024
Identification of key pharmacological components and targets for Aidi injection in the treatment of pancreatic cancer by UPLC-MS, network pharmacology, and in vivo experiments
Haojia Wang, Zhishan Wu, Xiaotian Fan, Chao Wu, Shan Lu, Libo Geng, Antony Stalin, Yingli Zhu, Fanqin Zhang, Jiaqi Huang, Pengyun Liu, Huiying Li, Leiming You, Jiarui Wu
Chinese Medicine United Kingdom, 2023
Exploring the effect of Yinzhihuang granules on alcoholic liver disease based on pharmacodynamics, network pharmacology and molecular docking
Yingying Tan, Fanqin Zhang, Xiaotian Fan, Shan Lu, Yingying Liu, Zhishan Wu, Zhihong Huang, Chao Wu, Guoliang Cheng, Bing Li, Jiaqi Huang, Antony Stalin, Wei Zhou, Jiarui Wu
Chinese Medicine United Kingdom, 2023
Data mining combines bioinformatics discover immunoinfiltration-related gene SERPINE1 as a biomarker for diagnosis and prognosis of stomach adenocarcinoma
Yiyan Zhai, Xinkui Liu, Zhihong Huang, Jingyuan Zhang, Antony Stalin, Yingying Tan, Fanqin Zhang, Meilin Chen, Rui Shi, Jiaqi Huang, Chao Wu, Zhishan Wu, Shan Lu, Leiming You, Jiarui Wu
Scientific Reports, 2023
Correction: Exploring the effect of Yinzhihuang granules on alcoholic liver disease based on pharmacodynamics, network pharmacology and molecular docking (Chinese Medicine, (2023), 18, 1, (52), 10.1186/s13020-023-00759-z)
Yingying Tan, Fanqin Zhang, Xiaotian Fan, Shan Lu, Yingying Liu, Zhishan Wu, Zhihong Huang, Chao Wu, Guoliang Cheng, Bing Li, Jiaqi Huang, Antony Stalin, Wei Zhou, Jiarui Wu
Chinese Medicine United Kingdom, 2023
Ecofriendly biofunctionalized gold nanoparticles using naturally available extract and evaluation of antioxidant, anticancer, antimicrobial and their toxicity in brine shrimp
Devan Elumalai, Maduraiveeran Hemavathi, Durai Mary, Rajan Renuka Remya, Hamid Naima, Antony Stalin, Rajendiran Keerthiga, Thodhal Yoganandham Suman
Biocatalysis and Agricultural Biotechnology, 2023
Effect of biofilm formation and cytotoxicity of biogenic silver nanoparticles (AgNPs) synthesized from a medicinal plant Sterculia foetida L.
N. Vasanth, , T. Dons, L. J. Michaelraj, P. Ganesan, S. H. Salmen, S. A. Alharbi, S. Mutheeswaran, M. Anthonysamy, S. Ignacimuthu, A. Stalin, , , , , , , , , and
Digest Journal of Nanomaterials and Biostructures, 2023
The Inhibitory Effect of Magnolol on the Human TWIK1 Channel Is Related to G229 and T225 Sites
Jintao Wang, Huan Liu, Zhuolin Sun, Xinyi Zou, Zixuan Zhang, Xiaofeng Wei, Lanying Pan, Antony Stalin, Wei Zhao, Yuan Chen
Molecules, 2023
Elucidation of Immune Regulation Mechanism of Renshen Guben Oral Liquid by Network Pharmacology and Molecular Docking
Ying-Ying Tan, Ying-Ying Liu, Jing-Yuan Zhang, Jia-Lin Li, Pei-Zhi Ye, Antony Stalin, Xiao-Tian Fan, Zhi-Hong Huang, Bing Li, Chao Wu, Shan Lu, Zhi-Shan Wu, Xiao-Meng Zhang, Guo-Liang Cheng, Jia-Rui Wu, Yan-Fang Mou
World Journal of Traditional Chinese Medicine, 2023
Compound Kushen Injection inhibits epithelial-mesenchymal transition of gastric carcinoma by regulating VCAM1 induced by the TNF signaling pathway
Zhihong Huang, Chao Wu, Wei Zhou, Shan Lu, Yingying Tan, Zhishan Wu, Rongli You, Antony Stalin, Fengying Guo, Jingyuan Zhang, Pengyun Liu, Wei Wang, Xiaoxia Duan, Leiming You, Jiarui Wu
Phytomedicine, 2023
Integrated network pharmacology analysis and in vitro validation revealed the underlying mechanism of Xiyanping injection in treating coronavirus disease 2019
Jialin Li, Siyu Guo, Yingying Tan, Jingyuan Zhang, Zhishan Wu, Antony Stalin, Fanqin Zhang, Zhihong Huang, Chao Wu, Xinkui Liu, Jiaqi Huang, Jiarui Wu
Medicine United States, 2023
Identification of an immune-related 6-lncRNA panel with a good performance for prognostic prediction in hepatocellular carcinoma by integrated bioinformatics analysis
Shan Lu, Xinkui Liu, Chao Wu, Jingyuan Zhang, Antony Stalin, Zhihong Huang, Yingying Tan, Zhishan Wu, Leiming You, Peizhi Ye, Changgeng Fu, Xiaomeng Zhang, Jiarui Wu
Medicine United States, 2023
The Strength of hERG Inhibition by Erythromycin at Different Temperatures Might Be Due to Its Interacting Features with the Channels
Dongrong Cheng, Xiaofeng Wei, Yanting Zhang, Qian Zhang, Jianwei Xu, Jiaxin Yang, Junjie Yu, Antony Stalin, Huan Liu, Jintao Wang, Dian Zhong, Lanying Pan, Wei Zhao, Yuan Chen
Molecules, 2023
Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels T cell-related prognostic risk model and tumor immune microenvironment modulation in triple-negative breast cancer
Siyu Guo, Xinkui Liu, Jingyuan Zhang, Zhihong Huang, Peizhi Ye, Jian Shi, Antony Stalin, Chao Wu, Shan Lu, Fanqin Zhang, Yifei Gao, Zhengseng Jin, Xiaoyu Tao, Jiaqi Huang, Yiyan Zhai, Rui Shi, Fengying Guo, Wei Zhou, Jiarui Wu
Computers in Biology and Medicine, 2023
Integrated serum pharmacochemistry, 16S rRNA sequencing and metabolomics to reveal the material basis and mechanism of Yinzhihuang granule against non-alcoholic fatty liver disease
Yingying Tan, Zhihong Huang, Yingying Liu, Xiaojiaoyang Li, Antony Stalin, Xiaotian Fan, Zhishan Wu, Chao Wu, Shan Lu, Fanqin Zhang, Meilin Chen, Jiaqi Huang, Guoliang Cheng, Bing Li, Siyu Guo, Yu Yang, Shuofeng Zhang, Jiarui Wu
Journal of Ethnopharmacology, 2023
Biocontrol efficacy of apigenin isolated from Anisomeles indica (L.) Kuntze against immature stages of Culex quinquefasciatus (Say, 1823) and its in silico studies
Rajan Samuel, Ganesan Pathalam, Velmurugan Babu, Ragavendran Kamaraj, Mutheeswaran Subramanian, Stalin Antony, Nagul Kumar Sanmugapriya, Senthilkumaar Palaniswamy, Ignacimuthu Savarimuthu
Biocatalysis and Agricultural Biotechnology, 2023
Inhibitory Effects of 2-Aminoethoxydiphenyl Borate (2-APB) on Three KV1 Channel Currents
Wei Zhao, Lanying Pan, Antony Stalin, Jianwei Xu, Liren Wu, Xianfu Ke, Yuan Chen
Molecules, 2023
Gold Nanoparticles: Clinical Applications
Sheikdawood Parveen, T. Sathiyapriya, D. Tharani, S. U. Mohammed Riyaz, Rakshi Anuja Dinesh, Jayashree Shanmugam, K. Rajakumar, Dmitry Zherebtsov, Manikandan Dhayalan, Antony Stalin
Engineering Materials, 2023
Corrigendum: Revealing the mechanism of Huazhi Rougan granule in the treatment of nonalcoholic fatty liver through intestinal flora based on 16S rRNA, metagenomic sequencing and network pharmacology (Frontiers in Pharmacology, (2022), 13, (875700), 10.3389/fphar.2022.875700)
Yingying Liu, Yingying Tan, Jiaqi Huang, Chao Wu, Xiaotian Fan, Antony Stalin, Shan Lu, Haojia Wang, Jingyuan Zhang, Fanqin Zhang, Zhishan Wu, Bing Li, Zhihong Huang, Meilin Chen, Guoliang Cheng, Yanfang Mou, Jiarui Wu
Frontiers in Pharmacology, 2023
T cell-related prognostic risk model and tumor immune environment modulation in lung adenocarcinoma based on single-cell and bulk RNA sequencing
Jingyuan Zhang, Xinkui Liu, Zhihong Huang, Chao Wu, Fanqin Zhang, Aiqing Han, Antony Stalin, Shan Lu, Siyu Guo, Jiaqi Huang, Pengyun Liu, Rui Shi, Yiyan Zhai, Meilin Chen, Wei Zhou, Meirong Bai, Jiarui Wu
Computers in Biology and Medicine, 2023
An advanced network pharmacology study to explore the novel molecular mechanism of Compound Kushen Injection for treating hepatocellular carcinoma by bioinformatics and experimental verification
Shan Lu, Ziqi Meng, Yingying Tan, Chao Wu, Zhihong Huang, Jiaqi Huang, Changgeng Fu, Antony Stalin, Siyu Guo, Xinkui Liu, Leiming You, Xiaojiaoyang Li, Jingyuan Zhang, Wei Zhou, Xiaomeng Zhang, Miaomiao Wang, Jiarui Wu
BMC Complementary Medicine and Therapies, 2022
Docking studies and thiourea-mediated reduced graphene oxide nanosheets' larvicidal efficacy against Culexquinquefasciatus
Babu Vimalanathan, Judith Vijaya John, Savarimuthu Ignacimuthu, Stalin Antony C, Magesh Daniel, Jayavel Ramasamy
Experimental Parasitology, 2022
Investigation on the efficiency of Brucea javanica oil emulsion injection with chemotherapy for treating malignant pleural effusion: A meta-analysis of randomized controlled trials
Rui Shi, Zhishan Wu, Haojia Wang, Jingyuan Zhang, Fanqin Zhang, Antony Stalin, Meilin Chen, Jiaqi Huang, Yiyan Zhai, Qianqian Zhang, Pengyun Liu, Jiarui Wu, Bin Sun, Chunfang Wu
Frontiers in Pharmacology, 2022
Therapeutic effects of shaogan fuzi decoction in rheumatoid arthritis: Network pharmacology and experimental validation
Lu Shi, Yiying Zhao, Chenran Feng, Feng Miao, Linlin Dong, Tianquan Wang, Antony Stalin, Jingyuan Zhang, Jingru Tu, Kexin Liu, Wenyan Sun, Jiarui Wu
Frontiers in Pharmacology, 2022
Single-Cell and Bulk RNA Sequencing Reveal Malignant Epithelial Cell Heterogeneity and Prognosis Signatures in Gastric Carcinoma
Zhihong Huang, Chao Wu, Xinkui Liu, Shan Lu, Leiming You, Fengying Guo, Antony Stalin, Jingyuan Zhang, Fanqin Zhang, Zhishan Wu, Yingying Tan, Xiaotian Fan, Jiaqi Huang, Yiyan Zhai, Rui Shi, Meilin Chen, Chunfang Wu, Huiying Li, Jiarui Wu
Cells, 2022
Identification of molecular mechanisms underlying the therapeutic effects of Xintong granule in coronary artery disease by a network pharmacology and molecular docking approach
Zhihong Huang, Siyu Guo, Changgeng Fu, Wei Zhou, Antony Stalin, Jingyuan Zhang, Xinkui Liu, Shanshan Jia, Chao Wu, Shan Lu, Bingbing Li, Zhishan Wu, Yingying Tan, Xiaotian Fan, Guoliang Cheng, Yanfang Mou, Jiarui Wu
Medicine United States, 2022
Mosquitocidal efficacy of embelin and its derivatives against Aedes aegypti L. and Culex quinquefasciatus Say. (Diptera: Culicidae) and computational analysis of acetylcholinesterase 1 (AChE1) inhibition
Antony Stalin, Appadurai Daniel Reegan, Munusamy Rajiv Gandhi, R.R Saravanan, Kedike Balakrishna, Abd El-Latif Hesham, Savarimuthu Ignacimuthu, Ying Zhang
Computers in Biology and Medicine, 2022
Wearable Flexible Electronics Based Cardiac Electrode for Researcher Mental Stress Detection System Using Machine Learning Models on Single Lead Electrocardiogram Signal
Md Belal Bin Heyat, Faijan Akhtar, Syed Jafar Abbas, Mohammed Al-Sarem, Abdulrahman Alqarafi, Antony Stalin, Rashid Abbasi, Abdullah Y. Muaad, Dakun Lai, Kaishun Wu
Biosensors, 2022
Revealing the Mechanism of Huazhi Rougan Granule in the Treatment of Nonalcoholic Fatty Liver Through Intestinal Flora Based on 16S rRNA, Metagenomic Sequencing and Network Pharmacology
Yingying Liu, Yingying Tan, Jiaqi Huang, Chao Wu, Xiaotian Fan, Antony Stalin, Shan Lu, Haojia Wang, Jingyuan Zhang, Fanqin Zhang, Zhishan Wu, Bing Li, Zhihong Huang, Meilin Chen, Guoliang Cheng, Yanfang Mou, Jiarui Wu
Frontiers in Pharmacology, 2022
Influence of co-ligand on the biological properties of Schiff base metal complexes: Synthesis, characterization, cytotoxicity, and antimicrobial studies
Thamilarasan Vijayan, Jinheung Kim, Mohammad Azam, Saud I. Al‐Resayes, Antony Stalin, Balakrishnan Senthamarai Kannan, Arumugam Jayamani, Arumugam Ayyakannu, Sengottuvelan Nallathambi
Applied Organometallic Chemistry, 2022
A novel strategy to reveal clinical advantages and molecular mechanism of aidi injection in the treatment of pancreatic cancer based on network meta-analysis and network pharmacology
Haojia Wang, Zhishan Wu, Yingying Liu, Miaomiao Wang, Antony Stalin, Siyu Guo, Jialin Li, Chao Wu, Jingyuan Zhang, Yingying Tan, Zhihong Huang, Shan Lu, Xiaotian Fan, Jiarui Wu
Journal of Ethnopharmacology, 2022
Revealing Calcium Signaling Pathway as Novel Mechanism of Danhong Injection for Treating Acute Myocardial Infarction by Systems Pharmacology and Experiment Validation
Siyu Guo, Yingying Tan, Zhihong Huang, Yikui Li, Weiyu Liu, Xiaotian Fan, Jingyuan Zhang, Antony Stalin, Changgeng Fu, Zhishan Wu, Penglong Wang, Wei Zhou, Xinkui Liu, Chao Wu, Shanshan Jia, Jinyan Zhang, Xiaoxia Duan, Jiarui Wu
Frontiers in Pharmacology, 2022
Synthesis, Molecular Docking and Mosquitocidal Efficacy of Lawsone and its Derivatives Against the Dengue Vector Aedes aegypti L. (Diptera: Culicidae)
Antony Stalin, Paul Dhivya, Ding Lin, Yue Feng, Antony Cruz Asharaja, Munusamy Rajiv Gandhi, Balakrishnan Senthamarai Kannan, Subramani Kandhasamy, Appadurai Daniel Reegan, Yuan Chen
Medicinal Chemistry, 2022
A New Strategy to Identify ceRNA-Based CCDC144NL-AS1/SERPINE1 Regulatory Axis as a Novel Prognostic Biomarker for Stomach Adenocarcinoma via High Throughput Transcriptome Data Mining and Computational Verification
Zhihong Huang, Xinkui Liu, Chao Wu, Shan Lu, Stalin Antony, Wei Zhou, Jingyuan Zhang, Zhishan Wu, Yingying Tan, Xiaotian Fan, Leiming You, Zhiwei Jing, Jiarui Wu
Frontiers in Oncology, 2022
Genome-wide identification and evolution of WNK kinases in Bambusoideae and transcriptional profiling during abiotic stress in Phyllostachys edulis
RongXiu Liu, Naresh Vasupalli, Dan Hou, Antony Stalin, Hantian Wei, Huicong Zhang, Xinchun Lin
Peerj, 2022
Computational analysis of single nucleotide polymorphisms (SNPs) in PPAR gamma associated with obesity, diabetes and cancer
Antony Stalin, Ding Lin, Johnson Josephine Princy, Yue Feng, Haiping Xiang, Savarimuthu Ignacimuthu, Yuan Chen
Journal of Biomolecular Structure and Dynamics, 2022
An in-silico approach to identify the potential hot spots in SARS-CoV-2 spike RBD to block the interaction with ACE2 receptor
Antony Stalin, Ding Lin, Balakrishnan Senthamarai Kannan, Yue Feng, Yanjing Wang, Wei Zhao, Savarimuthu Ignacimuthu, Dong-Qing Wei, Yuan Chen
Journal of Biomolecular Structure and Dynamics, 2022
Erratum to: Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies (Open Chem. (2022) 20:1(505-516) DOI: 10.1515/chem-2022-0164)
Mamta Tripathi, Ashish Kumar Asatkar, Stalin Antony, Mrinal Kanti Dash, Gourisankar Roymahapatra, Rama Pande, Avijit Sarkar, Fahad M. Aldakheel, Abdulkarim S. Binshaya, Nahed S. Alharthi, Ahmed L. Alaofi, Mohammed S. Alqahtani, Rabbani Syed
Open Chemistry, 2022
Copper(ii) complexes supported by modified azo-based ligands: Nucleic acid binding and molecular docking studies
Mamta Tripathi, Ashish Kumar Asatkar, Stalin Antony, Mrinal Kanti Dash, Gourisankar Roymahapatra, Rama Pande, Avijit Sarkar, Fahad M. Aldakheel, Abdulkarim S. Binshaya, Nahed S. Alharthi, Ahmed L. Alaofi, Mohammed S. Alqahtani, Rabbani Syed
Open Chemistry, 2022
Exploring the Multicomponent Synergy Mechanism of Yinzhihuang Granule in Inhibiting Inflammation-Cancer Transformation of Hepar Based on Integrated Bioinformatics and Network Pharmacology
Jingyuan Zhang, Zhihong Huang, Xinkui Liu, Chao Wu, Wei Zhou, Peizhi Ye, Antony Stalin, Shan Lu, Yingying Tan, Zhishan Wu, Xiaotian Fan, Xiaomeng Zhang, Miaomiao Wang, Bingbing Li, Guoliang Cheng, Yanfang Mou, Jiarui Wu
Biomed Research International, 2022
Exploring potential mechanisms of Suhexiang Pill against COVID-19 based on network pharmacology and molecular docking
Jialin Li, Zhihong Huang, Shan Lu, Hua Luo, Yingying Tan, Peizhi Ye, Xinkui Liu, Zhishan Wu, Chao Wu, Antony Stalin, Haojia Wang, Yingying Liu, Liangliang Shen, Xiaotian Fan, Bei Zhang, Jianping Yi, Lu Yao, Yi Xu, Jiarui Wu, Xianchun Duan
Medicine United States, 2021
Structure and pharmacological activities of polysaccharides from Anoectochilus roxburghii (Wall.) Lindl
Tong Wu, Shuailing Li, Yuqiu Huang, Zhen He, Ying Zheng, Antony Stalin, Qingsong Shao, Ding Lin
Journal of Functional Foods, 2021
A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation
Chao Wu, Zhi-Hong Huang, Zi-Qi Meng, Xiao-Tian Fan, Shan Lu, Ying-Ying Tan, Lei-Ming You, Jia-Qi Huang, Antony Stalin, Pei-Zhi Ye, Zhi-Shan Wu, Jing-Yuan Zhang, Xin-Kui Liu, Wei Zhou, Xiao-Meng Zhang, Jia-Rui Wu
Chinese Medicine United Kingdom, 2021
Investigation on the clinical efficacy and mechanism of compound kushen injection in treating esophageal cancer based on multi-dimensional network meta-analysis and in vitro experiment
Wei Zhou, Zhihong Huang, Chao Wu, Shan Lu, Changgeng Fu, Peizhi Ye, Yingying Tan, Zhishan Wu, Xiaotian Fan, Jingyuan Zhang, Siyu Guo, Shanshan Jia, Antony Stalin, Haojia Wang, Xiaomeng Zhang, Miaomiao Wang, Jiarui Wu
Journal of Ethnopharmacology, 2021
An Advanced Systems Pharmacology Strategy Reveals AKR1B1, MMP2, PTGER3 as Key Genes in the Competing Endogenous RNA Network of Compound Kushen Injection Treating Gastric Carcinoma by Integrated Bioinformatics and Experimental Verification
Wei Zhou, Chao Wu, Chongjun Zhao, Zhihong Huang, Shan Lu, Xiaotian Fan, Yingying Tan, Antony Stalin, Rongli You, Xinkui Liu, Jingyuan Zhang, Zhishan Wu, Jiarui Wu
Frontiers in Cell and Developmental Biology, 2021
Investigation on the mechanisms of guiqi huoxue capsule for treating cervical spondylosis based on network pharmacology and molecular docking
Yingying Liu, Jingyuan Zhang, Xinkui Liu, Wei Zhou, Antony Stalin, Changgeng Fu, Jiarui Wu, Guoliang Cheng, Siyu Guo, Shanshan Jia, Bingbing Li, Haojia Wang, Jialin Li, Shan Lu
Medicine United States, 2021
A Multidimensional Bayesian Network Meta-Analysis of Chinese Herbal Injections for Treating Non-small Cell Lung Cancer With Gemcitabine and Cisplatin
Mengwei Ni, Zhishan Wu, Haojia Wang, Wei Zhou, Chao Wu, Antony Stalin, Changgeng Fu, Peizhi Ye, Shan Lu, Yingying Tan, Zhihong Huang, Xiaotian Fan, Jingyuan Zhang, Xiaomeng Zhang, Miaomiao Wang, Jiarui Wu
Frontiers in Pharmacology, 2021
In vitro investigation of biophysical interactions between Ag(I) complexes of bis(methyl)(thia/selena)salen and ct-DNA via multi-spectroscopic, physicochemical and molecular docking methods along with cytotoxicity study
Mamta Tripathi, Rabbani Syed, Antony Stalin, Abdul Malik, Rama Pande, Ashish K. Asatkar
Luminescence, 2021
Hepatoprotective effect of selected isoandrographolide derivatives on steatotic HepG2 cells and High Fat Diet fed rats
Erenius Toppo, Naif Abdullah Al-Dhabi, Chinnakulandai Sankar, Sanmugapriya Nagul Kumar, Kanniappan Buvanesvaragurunathan, Santhanam Sylvester Darvin, Antony Stalin, Kedeke Balakrishna, Stanislaus Antony Ceasar, Perumal Pandikumar, Savarimuthu Ignacimuthu, Kuppusamy Sivasankaran, Paul Agastian
European Journal of Pharmacology, 2021
Physiochemical characterization and anti-carbapenemase activity of chitosan nanoparticles loaded Aegle marmelos essential oil against K. pneumoniae through DNA fragmentation assay
Govindan Rajivgandhi, Antony Stalin, Chelliah Chenthis Kanisha, Govindan Ramachandran, Natesan Manoharan, Naiyf S. Alharbi, Shine Kadaikunnan, Jamal M. Khaled, Khalid F. Alanzi, Wen-Jun Li
Surfaces and Interfaces, 2021
Mosquitocidal effect of monoterpene ester and its acetyl derivative from Blumea mollis (D. Don) Merr against Culex quinquefasciatus (Diptera: Culicidae) and their insilico studies
Sivanandhan Subramaniyan, Ganesan Pathalam, Stalin Antony, Gabriel Paulraj Michael, Rajan Samuel, Balakrishna Kedike, Anand Sekar, Ahilan Boovaragamurthy, Shirota Osamu, Ahmed Hossam Mahmoud, Osama B Mohammed, Ignacimuthu Savarimuthu
Experimental Parasitology, 2021
Synthesis, absorption, emission and solvatochromic investigation of bioactive isatin tethered acridinedione conjugates
Govindasami Periyasami, Ponmurugan Karuppiah, Antony Stalin, Saradh Prasad, Mostafizur Rahaman, Abdul-Aziz Alrehaili, Naif Abdullah Al-Dhabi, Ali Aldalbahi
Materials Today Communications, 2021
Effect of monoterpene ester from Blumea axillaris (Lam.) DC and its acetyl derivative against plant pathogenic fungi and their in silico molecular docking
Subramaniyan Sivanandhan, Ganesan Pathalam, Stalin Antony, Gabriel Paulraj Michael, Kedike Balakrishna, Ahilan Boovaragamurthy, Osamu Shirota, Mona S Alwahibi, Mohamed Soliman El-Shikh, Savarimuthu Ignacimuthu
Natural Product Research, 2021
Geranii herba as a potential inhibitor of SARS-CoV-2 main 3CLpro, spike RBD, and regulation of unfolded protein response: An in silico approach
Selvaraj Arokiyaraj, Antony Stalin, Balakrishnan Senthamarai Kannan, Hakdong Shin
Antibiotics, 2020
Synthesis of a 1,2,3-bistriazole derivative of embelin and evaluation of its effect on high-fat diet fed-streptozotocin-induced type 2 diabetes in rats and molecular docking studies
Antony Stalin, Subramani Kandhasamy, Balakrishnan Senthamarai Kannan, Rama Shanker Verma, Savarimuthu Ignacimuthu, Yrjälä Kim, Qingsong Shao, Yuan Chen, Perumal Palani
Bioorganic Chemistry, 2020
Anti-methanogenic effect of rhubarb (Rheum spp.) – An in silico docking studies on methyl-coenzyme M reductase (MCR)
Selvaraj Arokiyaraj, Antony Stalin, Hakdong Shin
Saudi Journal of Biological Sciences, 2019
A competent synthesis and efficient anti-inflammatory responses of isatinimino acridinedione moiety via suppression of in vivo NF-κB, COX-2 and iNOS signaling
Govindasami Periyasami, Paulrayer Antonisamy, Karthikeyan Perumal, Antony Stalin, Mostafizur Rahaman, Asma A. Alothman
Bioorganic Chemistry, 2019
Effect of tiliamosine, a bis, benzylisoquinoline alkaloid isolated from Tiliacora acuminata (Lam.) Hook. f. & Thom on the immature stages of filarial mosquito Culex quinquefasciatus say (Diptera: Culicidae)
Sylvester Darvin Sandhanam, Ganesan Pathalam, Stalin Antony, Rajan Samuel, Gabriel Paulraj Michael, Balakrishna Kedike, Perumal Pandikumar, Ignacimuthu Savarimuthu, Naif Abdullah Al-Dhabi
Experimental Parasitology, 2019
Glucosamine-6-phosphate synthase inhibiting C3-β-cholesterol tethered spiro heterocyclic conjugates: Synthesis and their insight of DFT and docking study
Govindasami Periyasami, Subban Kamalraj, Ramanathan Padmanaban, Santhakumar Yeswanth Kumar, Antony Stalin, Natarajan Arumugam, Raju Suresh Kumar, Mostafizur Rahaman, Periyan Durairaju, Abdulaziz Alrehaili, Ali Aldalbahi
Bioorganic Chemistry, 2019
Hepatoprotective effect of bisbenzylisoquinoline alkaloid tiliamosine from Tiliacora racemosa in high-fat diet/diethylnitrosamine-induced non-alcoholic steatohepatitis
S. Sylvester Darvin, Erenius Toppo, S. Esakkimuthu, T.P. Ajeesh Krishna, S. Antony Ceasar, A. Stalin, K. Balakrishna, N. Muniappan, N. Pazhanivel, R. Mahaprabhu, M. Gabriel Paulraj, P. Pandikumar, S. Ignacimuthu, N.A. Al-Dhabi
Biomedicine and Pharmacotherapy, 2018
Curative effect of arjunolic acid from Terminalia arjuna in non-alcoholic fatty liver disease models
Erenius Toppo, S. Sylvester Darvin, S. Esakkimuthu, K. Buvanesvaragurunathan, T.P. Ajeesh Krishna, S. Antony Caesar, A. Stalin, K. Balakrishna, P. Pandikumar, S. Ignacimuthu, N.A. Al-Dhabi
Biomedicine and Pharmacotherapy, 2018
Biocontrol and non-target effect of fractions and compound isolated from Streptomyces rimosus on the immature stages of filarial vector Culex quinquefasciatus Say (Diptera: Culicidae) and the compound interaction with Acetylcholinesterase (AChE1)
Pathalam Ganesan, Antony Stalin, Micheal Gabriel Paulraj, Kedike Balakrishna, Savarimuthu Ignacimuthu, Naif Abdullah Al-Dhabi
Ecotoxicology and Environmental Safety, 2018
Effect of compound isolated from Lawsonia inermis (L.) (Myrtales: Lythraceae) on the immature stages of filarial vector Culex quinquefasciatus Say (Diptera: Culicidae) and its docking analysis with Acetylcholinesterase (AChE1)
Sylvester Darvin Sandhanam, Pathalam Ganesan, Antony Stalin, Gabriel Paulraj Michael, Kedike Balakrishna, Perumal Pandikumar, Savarimuthu Ignacimuthu, Abdullah Al-Dhabi Naif
Biocatalysis and Agricultural Biotechnology, 2018
Synthesis of novel β-amino alcohols from phenylacetylcarbinol: cytotoxicity activity against A549 cells and molecular docking
Prabhu Mahendran, A. Jeya Rajendran, C. Balachandran, A. Stalin, Saravanan Rangan, Loganathan Kothandapani, Kella Chennakesava Rao, Suresh Awale, B. N. Hiteshkumar
Research on Chemical Intermediates, 2018
Exploration of cell cycle regulation and modulation of the DNA methylation mechanism of pelargonidin: Insights from the molecular modeling approach
Natesan Karthi, Arumugasamy Karthiga, Thangaraj Kalaiyarasu, Antony Stalin, Vaiyapuri Manju, Sanjeev Kumar Singh, Ravi Cyril, Sang-Myeong Lee
Computational Biology and Chemistry, 2017
Antihyperlipidemic and hepatoprotective effects of Gardenin A in cellular and high fat diet fed rodent models
Erenius Toppo, S. Sylvester Darvin, S. Esakkimuthu, A. Stalin, K. Balakrishna, K. Sivasankaran, P. Pandikumar, S. Ignacimuthu, N.A. Al-Dhabi
Chemico Biological Interactions, 2017
Myoinositol ameliorates high-fat diet and streptozotocin-induced diabetes in rats through promoting insulin receptor signaling
Poovathumkal James Antony, Gopalsamy Rajiv Gandhi, Antony Stalin, Kedike Balakrishna, Erenius Toppo, Kuppusamy Sivasankaran, Savarimuthu Ignacimuthu, Naif Abdullah Al-Dhabi
Biomedicine and Pharmacotherapy, 2017
Protective effects of Ficus carica leaves on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats
Santiagu Stephen Irudayaraj, Sunil Christudas, Stalin Antony, Veeramuthu Duraipandiyan, Al-Dhabi Naif Abdullah, Savarimuthu Ignacimuthu
Pharmaceutical Biology, 2017
Identifying potential PPARγ agonist/partial agonist from plant molecules to control type 2 diabetes using in silico and in vivo models
Antony Stalin, Santiagu Stephen Irudayaraj, Dhandapani Ramesh Kumar, Kedike Balakrishna, Savarimuthu Ignacimuthu, Naif Abdullah Al-Dhabi, Veeramuthu Duraipandiyan
Medicinal Chemistry Research, 2016
Antioxidant, antilipidemic and antidiabetic effects of ficusin with their effects on GLUT4 translocation and PPARγ expression in type 2 diabetic rats
Santiagu Stephen Irudayaraj, Antony Stalin, Christudas Sunil, Veeramuthu Duraipandiyan, Naif Abdullah Al-Dhabi, Savarimuthu Ignacimuthu
Chemico Biological Interactions, 2016
In silico molecular docking of niloticin with acetylcholinesterase 1 (AChE1) of Aedes aegypti L. (Diptera: Culicidae): a promising molecular target
Appadurai Daniel Reegan, Antony Stalin, Michael Gabriel Paulraj, Kedike Balakrishna, Savarimuthu Ignacimuthu, Naif Abdullah Al-Dhabi
Medicinal Chemistry Research, 2016
Hypoglycemic activity of 6-bromoembelin and vilangin in high-fat diet fed-streptozotocin-induced type 2 diabetic rats and molecular docking studies
Antony Stalin, Santiagu Stephen Irudayaraj, Gopalsamy Rajiv Gandhi, Kedike Balakrishna, Savarimuthu Ignacimuthu, Naif Abdullah Al-Dhabi
Life Sciences, 2016
In silico docking analysis to explore the proapoptotic and anti cell proliferative potential of ferulic acid
Indian Journal of Biochemistry and Biophysics, 2016
Isolation and characterization of Anthraquinone from Streptomyces sp. ERINLG-26 with anticancer activity Against adenocarcinoma cell line COLO320
C. Balachandran, V. Duraipandiyan, N. A. Al-Dhabi, A. Stalin, K. Balakrishna, S. Ignacimuthu, F. Tilton
Applied Biochemistry and Microbiology, 2015
γ-sitosterol a potent hypolipidemic agent: In silico docking analysis
Rangachari Balamurugan, Antony Stalin, Adithan Aravinthan, Jong-Hoon Kim
Medicinal Chemistry Research, 2015
Gallic acid attenuates high-fat diet fed-streptozotocin-induced insulin resistance via partial agonism of PPARγ in experimental type 2 diabetic rats and enhances glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway
Gopalsamy Rajiv Gandhi, Gnanasekaran Jothi, Poovathumkal James Antony, Kedike Balakrishna, Michael Gabriel Paulraj, Savarimuthu Ignacimuthu, Antony Stalin, Naif Abdullah Al-Dhabi
European Journal of Pharmacology, 2014
Polyphenols-rich Cyamopsis tetragonoloba (L.) Taub. beans show hypoglycemic and β-cells protective effects in type 2 diabetic rats
Gopalsamy Rajiv Gandhi, Pautu Vanlalhruaia, Antony Stalin, Santiagu Stephen Irudayaraj, Savarimuthu Ignacimuthu, Michael Gabriel Paulraj
Food and Chemical Toxicology, 2014
Insulin sensitization via partial agonism of PPARγ and glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway by embelin in type 2 diabetic rats
Gopalsamy Rajiv Gandhi, Antony Stalin, Kedike Balakrishna, Savarimuthu Ignacimuthu, Michael Gabriel Paulraj, Rajagopal Vishal
Biochimica Et Biophysica Acta General Subjects, 2013
Molecular docking of γ-sitosterol with some targets related to diabetes
Rangachari Balamurugan, Antony Stalin, Savarimuthu Ignacimuthu
European Journal of Medicinal Chemistry, 2012

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