Biochemistry, Cancer Research, Molecular Biology, Drug Discovery
27
Scopus Publications
827
Scholar Citations
17
Scholar h-index
18
Scholar i10-index
Scopus Publications
Alteration of hematological and biochemical parameters in dengue: Implication for patient management Pradeep Kumar Gupta, Dakshina Bisht, Vishal Aggarwal, Sivanesan Dhandayuthapani Ip International Journal of Medical Microbiology and Tropical Diseases, 2026 Background: Dengue is a major mosquito-borne viral illness and remains a significant public health problem in India. Owing to its varied clinical presentation and epidemiological patterns, accurate laboratory diagnosis and close monitoring of disease-related parameters are essential for effective patient management. This study aimed to analyse laboratory-confirmed dengue cases and evaluate the associated haematological and biochemical alterations that may assist in disease monitoring and prognosis.Materials and Methods: A prospective analytical study was conducted on 244 laboratory-confirmed dengue-positive patients. Serological diagnosis was performed using NS1 antigen ELISA and dengue IgM ELISA. Haematological parameters and biochemical markers, including liver function tests (LFTs) and kidney function tests (KFTs), were assessed using automated analysers.Results: Among the dengue-positive cases, 53.45% were positive for NS1 antigen, 32.70% for IgM antibodies, and 14.75% for both NS1 antigen and IgM. Fever was observed in all patients (100%). Thrombocytopenia (platelet count
Electronic resources literacy and e-reading behaviour among nursing students Neelam Tiwary, Saravanakumaran Subramani, Manjulavathi G, Sivanesan Dhandayuthapani Global Knowledge Memory and Communication, 2025 Purpose The study aims to determine the level of e-reading habits and preferred electronic reading materials among nursing college students. The study examines students’ problems and difficulties using electronic resources and their knowledge of electronic literacy. Over the recent years, worldwide interest in reading electronic books has skyrocketed. Design/methodology/approach This study uses a survey research design and a structured closed-ended questionnaire as the data collection instrument. The sample population consists of college students. The study uses a quantitative method to investigate this population’s e-reading habits and preferred electronic reading materials. Findings The study findings indicate that while students prefer electronic resources, they need help accessing them due to various factors such as cost and availability. The survey results show that libraries must subscribe to a broader range of electronic resources, and academics and publishers must promote open-access articles to address these limitations. Originality/value The study addresses a current issue of students’ reading habits and preferred electronic reading materials and examines the limitations they face in accessing these resources. This research concludes that 21st-century students have transitioned from traditional to digital reading habits. They have a preference for electronic resources but their access to these resources is limited.
Biocatalytic Potential of Pseudomonas Species in the Degradation of Polycyclic Aromatic Hydrocarbons Sivabalan Sivasamy, Shanmuganathan Rajangam, Thanigaivelan Kanagasabai, Dakshina Bisht, Rajkumar Prabhakaran, Sivanesan Dhandayuthapani Journal of Basic Microbiology, 2025 Polycyclic aromatic hydrocarbons (PAHs), one of the major environmental pollutants, produced from incomplete combustion of materials like coal, oil, gas, wood, and charbroiled meat, that contaminate the air, soil, and water, necessitating urgent remediation. Understanding the metabolic pathways for PAHs degradation is crucial to preventing environmental damage and health issues. Biological methods are gaining increasing interest due to their cost‐effectiveness and environmental friendliness. These methods are particularly suitable for remediating PAHs contamination and mitigating associated risks. The paper also outlines the processes for biodegrading PAHs, emphasizing the function of Pseudomonas spp., a kind of bacterium recognized for its capacity to degrade PAHs. To eliminate PAHs from the environment and reduce threats to human health and the environment, Pseudomonas spp. is essential. Understanding the mechanism of PAH breakdown by means of microbes could lead to effective clean‐up strategies. The review highlights the enzymatic capabilities, adaptability, and genetic versatility of the genes like nah and phn of Pseudomonas spp., which are involved in PAHs degradation pathways. Scientific evidence supports using Pseudomonas spp. as biocatalysts for PAHs clean‐up, offering cost‐effective and eco‐friendly solutions.
D-dimer as a potential biomarker in chronic obstructive pulmonary disease , Anish V. Patel, Mayurika S. Tyagi, , Adreena Mittal, , Sumit Chandra, , Hina Kausar, , Sivanesan Dhandayuthapani, and European Journal of Clinical and Experimental Medicine, 2025 Introduction and aim. Despite signs of drop in tuberculosis in the middle of the twentieth century, up to 75% of men were smokers at that time, which contributed to the epidemic of chronic obstructive pulmonary disease (COPD) in the latter half of the century. The present study was conducted with the main focus of establishing a relation between D-dimer and lung function in patients with COPD. Material and methods. A hospital-based observational cross-sectional study involved 108 subjects, divided into 54 cases (COPD patients) and 54 healthy controls (41-80 years old). The dry volume spirometer was used to assess the lung health of the study population. D-dimer assay was performed on peripheral blood drawn from study subjects using the second generation latex-enhanced immunoturbidimetric assay on the Diagon Fully Automatic COAG XL Coagulation Analyzer. Results. Spirometry tests revealed COPD patients showing reduced lung function (42.59% with normal, 51.85% with mild, and 5.56% with moderate degree of forced expiratory volume in 1 second and forced expiratory volume in 1 second/ forced vital capacity). Patients with COPD under different age groups and both the genders showed an elevated level (p<0.05) of D-dimer in correlation with the spirometry measurements. Conclusion. The D-dimer is promising plasma biomarker which demonstrated a strong correlation with the spirometry measurements and different morphological categories in patients with COPD. The D-dimer could serve as a reliable biomarker for validating and confirming the various morphological classifications among individuals with COPD.
Epigenetic frontiers: miRNAs, long non-coding RNAs and nanomaterials are pioneering to cancer therapy Rajkumar Prabhakaran, Rajkumar Thamarai, Sivabalan Sivasamy, Sivanesan Dhandayuthapani, Jyoti Batra, Chinnaperumal Kamaraj, Krishnasamy Karthik, Mohd Asif Shah, Saurav Mallik Epigenetics and Chromatin, 2024 Cancer has arisen from both genetic mutations and epigenetic changes, making epigenetics a crucial area of research for innovative cancer prevention and treatment strategies. This dual perspective has propelled epigenetics into the forefront of cancer research. This review highlights the important roles of DNA methylation, histone modifications and non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) and long non-coding RNAs, which are key regulators of cancer-related gene expression. It explores the potential of epigenetic-based therapies to revolutionize patient outcomes by selectively modulating specific epigenetic markers involved in tumorigenesis. The review examines promising epigenetic biomarkers for early cancer detection and prognosis. It also highlights recent progress in oligonucleotide-based therapies, including antisense oligonucleotides (ASOs) and antimiRs, to precisely modulate epigenetic processes. Furthermore, the concept of epigenetic editing is discussed, providing insight into the future role of precision medicine for cancer patients. The integration of nanomedicine into cancer therapy has been explored and offers innovative approaches to improve therapeutic efficacy. This comprehensive review of recent advances in epigenetic-based cancer therapy seeks to advance the field of precision oncology, ultimately culminating in improved patient outcomes in the fight against cancer.
Exploring Cutting-Edge Approaches in Anaerobic Digestion and Anaerobic Digestate Management Iyyadurai Mariappan, Rajkumar Prabhakaran, Vivekanand Vivekanand, Merlin Sobia Poomani, Krishnaveni Muthan, Sivanesan Dhandayuthapani, Sivabalan Sivasamy, Rathika Regurajan, Venkatesh Subramanian Chembioeng Reviews, 2024 Exploring alternative energy sources is vital amid increasing human fuel consumption. Globally, biogas, rich in methane, hydrogen sulfide, and carbon dioxide, addresses energy demands through biomass anaerobic digestion (AD). Efficient digestate management, employing techniques like solid‐liquid separation and composting, is crucial for environmental protection. The goal is to optimize nutrient‐rich byproduct utilization while minimizing negative impacts. This review analyzes diverse substrates, emphasizing challenges and benefits. Key considerations include nutrient ratios, moisture content, co‐digestion, organic loading rate, and retention time. The study explores temperature's impact on microbial growth, biogas impurities, and upgradation techniques, including biological methods. Fermentation, microbial electrochemical techniques, and biochar use for enhanced AD are introduced. Discussing digestate's multifaceted aspects, the review highlights its nutrient value and diverse applications in aquaculture, animal feed, fermentation, bioremediation, and fine chemical production.
Bortezomib in Combination with Physachenolide C Reduces the Tumorigenic Properties of KRASmut/P53mut Lung Cancer Cells by Inhibiting c-FLIP Thanigaivelan Kanagasabai, Zerick Dunbar, Salvador González Ochoa, Tonie Farris, Sivanesan Dhandayuthapani, E. M. Kithsiri Wijeratne, A. A. Leslie Gunatilaka, Anil Shanker Cancers, 2024 Background: Defects in apoptosis regulation are one of the classical features of cancer cells, often associated with more aggressiveness and failure to therapeutic options. We investigated the combinatorial antitumor effects of a natural product, physachenolide C (PCC) and bortezomib, in KRASmut/P53mut lung cancer cells and xenograft mice models. Methods: The in vitro anticancer effects of the bortezomib and PCC combination were investigated using cell viability, migration, and invasion assays in 344SQ, H23, and H358 cell lines. Furthermore, the effects of combination treatment on the critical parameters of cellular metabolism, including extracellular acidification rate (ECAR) and mitochondrial oxidative phosphorylation based on the oxygen consumption rate of cancer cells were assessed using Seahorse assay. Finally, the antitumor effect of the bortezomib (1 mg/kg) and PCC (10 mg/kg) combination was evaluated using xenograft mice models. Results: Our data showed that the bortezomib–PCC combination was more effective in reducing the viability of lung cancer cells in comparison with the individual treatments. Similarly, the combination treatment showed a significant inhibition of cell migration and invasion of cancer cells. Additionally, the key anti-apoptotic protein c-FLIP was significantly inhibited along with a substantial reduction in the key parameters of cellular metabolism in cancer cells. Notably, the bortezomib or PCC inhibited the tumor growth compared to the control group, the tumor growth inhibition was much more effective when bortezomib was combined with PCC in tumor xenograft mice models. Conclusion: These findings demonstrate that PCC sensitizes cancer cells to bortezomib, potentially improving the antitumor effects against KRASmut/P53mut lung cancer cells, with an enhanced efficacy of combination treatments without causing significant side effects.
Male Breast Cancer: Current Scenario and Future Perspectives Anitha Chidambaram, Rajkumar Prabhakaran, Sivabalan Sivasamy, Thanigaivelan Kanagasabai, Malarvili Thekkumalai, Ankit Singh, Mayurika S. Tyagi, Sivanesan Dhandayuthapani Technology in Cancer Research and Treatment, 2024 Male breast cancer (MBC), one of the rare types of cancer among men where the global incidence rate is 1.8% of all breast cancers cases with a yearly increase in a pace of 1.1%. Since the last 10 years, the incidence has been increased from 7.2% to 10.3% and the mortality rate was decreased from 11% to 3.8%. Nevertheless, the rate of diagnoses has been expected to be around 2.6% in the near future, still there is a great lack in studies to characterize the MBC including the developed countries. Based on our search, it is evidenced from the literature that the number of risk factors for the cause of MBC are significant, which includes the increase in age, family genetic history, mutations in specific genes due to various environmental impacts, hormonal imbalance and unregulated expression receptors for specific hormones of high levels of estrogen or androgen receptors compared to females. MBCs are broadly classified into ductal and lobular carcinomas with further sub-types, with some of the symptoms including a lump or swelling in the breast, redness of flaky skin in the breast, irritation and nipple discharge that is similar to the female breast cancer (FBC). The most common diagnostic tools currently in use are the ultrasound guided sonography, mammography, and biopsies. Treatment modalities for MBC include surgery, radiotherapy, chemotherapy, hormonal therapy, and targeted therapies. However, the guidelines followed for the diagnosis and treatment modalities of MBC are mostly based on FBC that is due to the lack of prospective studies related to MBC. However, there are distinct clinical and molecular features of MBC, it is a need to develop different clinical methods with more multinational approaches to help oncologist to improve care for MBC patients.
Erratum: Cytotoxic effect of pumpkin (curcurbita pepo) seed extracts in lncap prostate cancer cells is mediated through apoptosis (Current Topics in Nutraceutical Research (2013) 11:4 (137-144)) Current Topics in Nutraceutical Research, 2014
Modulatory effect of Gynandropsis gynandra L. on glucose metabolizing enzymes in aflatoxin B1-induced hepatocellular carcinoma in rats Indian Journal of Biochemistry and Biophysics, 2007
Preventive role of gynandropsis gynandra L., against aflatoxin B1 induced lipid peroxidation and antioxidant defense mechanism in rat Indian Journal of Experimental Biology, 2007
Hypolipidemic activity of Enicostemma littorale (root) on DAB induced hepatotoxicity in male albino rats Biomedicine, 2003
RECENT SCHOLAR PUBLICATIONS
Electronic resources literacy and e-reading behaviour among nursing students N Tiwary, S Subramani, M G, S Dhandayuthapani Global Knowledge, Memory and Communication 74 (9-10), 3132-3146 , 2025 2025 Citations: 3
A Comparative Evaluation of the Efficacy and Safety Profile of Cariprazine and Olanzapine in Patients With Schizophrenia in a Tertiary Care Hospital S Tiwari, B Saran, S Dhandayuthapani, VT Yadav, J Batra, S Dey, ... Cureus 17 (9) , 2025 2025
THE NEUROBIOLOGICAL CONCEPTS AND TREATMENT REGIMEN OF SCHIZOPHRENIA. S Tiwari, S Dey, B Saran, S Dhandayuthapani, VT Yadav, J Batra International Journal of Medicine & Public Health 15 (2) , 2025 2025
Biocatalytic Potential of Pseudomonas Species in the Degradation of Polycyclic Aromatic Hydrocarbons S Sivasamy, S Rajangam, T Kanagasabai, D Bisht, R Prabhakaran, ... Journal of Basic Microbiology 65 (2), e2400448 , 2025 2025 Citations: 25
Sociodemographic factors on intimate partner violence: Insights from a population-based study using fifth round of the National Family Health Survey VS Patel, J Batra, SHN Zaidi, S Dhandayuthapani Santosh University Journal of Health Sciences 11 (1), 23-30 , 2025 2025
D-dimer as a potential biomarker in chronic obstructive pulmonary disease AV Patel, MS Tyagi, A Mittal, S Chandra, H Kausar, S Dhandayuthapani Rzeszów University Press , 2025 2025 Citations: 1
Epigenetic frontiers: miRNAs, long non-coding RNAs and nanomaterials are pioneering to cancer therapy R Prabhakaran, R Thamarai, S Sivasamy, S Dhandayuthapani, J Batra, ... Epigenetics & Chromatin 17 (1), 31 , 2024 2024 Citations: 64
Complexity, advances, adaptation, and shaping the future of medical ethics S Sivasamy, VS Patel, R Prabhakaran, S Dhandayuthapani, J Batra Santosh University Journal of Health Sciences 10 (2), 254-264 , 2024 2024 Citations: 1
Male breast cancer: current scenario and future perspectives A Chidambaram, R Prabhakaran, S Sivasamy, T Kanagasabai, ... Technology in Cancer Research & Treatment 23, 15330338241261836 , 2024 2024 Citations: 30
Exploring cutting‐edge approaches in anaerobic digestion and anaerobic digestate management I Mariappan, R Prabhakaran, V Vivekanand, MS Poomani, K Muthan, ... ChemBioEng Reviews 11 (3), 573-594 , 2024 2024 Citations: 16
Bortezomib in Combination with Physachenolide C Reduces the Tumorigenic Properties of KRAS mut /P53 mut Lung Cancer Cells by Inhibiting c-FLIP T Kanagasabai, Z Dunbar, SG Ochoa, T Farris, S Dhandayuthapani, ... Cancers 16 (3), 670 , 2024 2024 Citations: 1
Breaking the mold: Unveiling male breast cancer through a compelling case study S Singh, HK Butt, MS Tyagi, S Dhandayuthapani, P Gulati Santosh University Journal of Health Sciences 9 (2), 240-242 , 2023 2023 Citations: 1
AN ANALYSIS OF EFFECTIVENESS OF VARIOUS DRUGS USED IN THE TREATMENT OF COVID-19 TREATMENT R Sharma, J Sharma, S Dutta, S Kumar, MSIS Gupta, S Kumari, VB Lote, ... Int J Acad Med Pharm 5 (6), 1069-1072 , 2023 2023
Comprehensive analysis of research outcomes from selected Indian Council of Medical Research Institutes: Trends and insights from 1989 to 2021 S Subramani, S Dhandayuthapani Santosh University Journal of Health Sciences 9 (1), 95-103 , 2023 2023 Citations: 2
Knowledge, attitudes, and practices in transport workers and gym-goers toward COVID-19: A cross-sectional survey in Ghaziabad, India P Das, P Singh, S Dhandayuthapani, S Tomo, CS Mahendran Santosh University Journal of Health Sciences 9 (1), 87-90 , 2023 2023
A comparative study on the efficacy of pranayama and dietary restriction on altered body mass index and thyroid-stimulating hormone in middle-aged women with subclinical … S Subramani, R Prabhakaran, S Dutta, J Batra, TS Bhagat, ... Santosh University Journal of Health Sciences 9 (1), 91-94 , 2023 2023
Factors associated with bronchial asthma: Analysis of parameters in a tertiary care center, Ghaziabad P Das, CS Mahendran, E Chandra, S Dhandayuthapani, V Bhardwaj Santosh University Journal of Health Sciences 9 (1), 83-86 , 2023 2023
Post-COVID-19 impacts on male sexual and reproductive functions A Bansal, B Saran, TS Bhagat, J Batra, S Dhandayuthapani Santosh University Journal of Health Sciences 9 (1), 76-79 , 2023 2023
Genetic Polymorphism in Papillary Thyroid Cancerm j in North Indian Population–A review H Soni, J Batra, S Dhandayuthapani, A Mishra, J Aggarwal Cardiometry, 1188-1191 , 2022 2022
Generation of Reactive Oxygen Species and its Defense Mechanism during Aflatoxin B 1 Contamination: An Overview. S Dhandayuthapani, A Chidambaram, M Thekkumalai, J Batra Journal of Pharmaceutical Negative Results 13 , 2022 2022
MOST CITED SCHOLAR PUBLICATIONS
Phycocyanin induces apoptosis and enhances the effect of topotecan on prostate cell line LNCaP M Gantar, S Dhandayuthapani, A Rathinavelu Journal of medicinal food 15 (12), 1091-1095 , 2012 2012 Citations: 136
Bromelain-induced apoptosis in GI-101A breast cancer cells S Dhandayuthapani, HD Perez, A Paroulek, P Chinnakkannu, ... Journal of medicinal food 15 (4), 344-349 , 2012 2012 Citations: 86
Induction of apoptosis in HeLa cells via caspase activation by resveratrol and genistein S Dhandayuthapani, P Marimuthu, V Hörmann, J Kumi-Diaka, ... Journal of medicinal food 16 (2), 139-146 , 2013 2013 Citations: 84
Epigenetic frontiers: miRNAs, long non-coding RNAs and nanomaterials are pioneering to cancer therapy R Prabhakaran, R Thamarai, S Sivasamy, S Dhandayuthapani, J Batra, ... Epigenetics & Chromatin 17 (1), 31 , 2024 2024 Citations: 64
MDM2 overexpression modulates the angiogenesis-related gene expression profile of prostate cancer cells T Venkatesan, A Alaseem, A Chinnaiyan, S Dhandayuthapani, ... Cells 7 (5), 41 , 2018 2018 Citations: 41
Urtica dioica Induces Cytotoxicity in Human Prostate Carcinoma LNCaP Cells: Involvement of Oxidative Stress, Mitochondrial Depolarization and Apoptosis. A Levy, D Sivanesan, R Murugan, J Jornadal, Y Quinonez, M Jaffe, ... Tropical Journal of Pharmaceutical Research 13 (5) , 2014 2014 Citations: 41
Antioxidant and Hypolipidemic Effect of Plumeria Rubra L. in Alloxan Induced Hyperglycemic Rats AJ Merina, D Sivanesan, VH Begum, N Sulochana Journal of Chemistry 7 (1), 1-5 , 2010 2010 Citations: 41
Apoptosis Induction by Ocimum sanctum Extract in LNCaP Prostate Cancer Cells S Dhandayuthapani, H Azad, A Rathinavelu Journal of medicinal food 18 (7), 776-785 , 2015 2015 Citations: 38
Molecular mechanism of C-phycocyanin induced apoptosis in LNCaP cells P Kaur, S Dhandayuthapani, T Venkatesan, M Gantor, A Rathinavelu Bioorganic & Medicinal Chemistry 28 (3), 115272 , 2020 2020 Citations: 33
Male breast cancer: current scenario and future perspectives A Chidambaram, R Prabhakaran, S Sivasamy, T Kanagasabai, ... Technology in Cancer Research & Treatment 23, 15330338241261836 , 2024 2024 Citations: 30
Preventive role of Gynandropsis gynandra L., against aflatoxin B~ 1 induced lipid peroxidation and antioxidant defense mechanism in rat D Sivanesan, VH Begum Indian journal of experimental biology 45 (3), 299 , 2007 2007 Citations: 30
Cytotoxic effect of pumpkin (Curcurbita pepo) seed extracts in LNCaP prostate cancer cells is mediated through apoptosis A Rathinavelu, A Levy, D Sivanesan, D Murugan, J Jornadal, Y Quinonez, ... Current Topics in Nutraceuticals Research 11 (4), 137 , 2013 2013 Citations: 26
Biocatalytic Potential of Pseudomonas Species in the Degradation of Polycyclic Aromatic Hydrocarbons S Sivasamy, S Rajangam, T Kanagasabai, D Bisht, R Prabhakaran, ... Journal of Basic Microbiology 65 (2), e2400448 , 2025 2025 Citations: 25
Differential mechanisms involved in RG-7388 and Nutlin-3 induced cell death in SJSA-1 osteosarcoma cells U Natarajan, T Venkatesan, S Dhandayuthapani, P Dondapatti, ... Cellular Signalling 75, 109742 , 2020 2020 Citations: 20
Anti-cancer effects of F16: A novel vascular endothelial growth factor receptor–specific inhibitor A Rathinavelu, K Alhazzani, S Dhandayuthapani, T Kanagasabai Tumor Biology 39 (11), 1010428317726841 , 2017 2017 Citations: 19
Pro-angiogenic effects of MDM2 through HIF-1α and NF-κB mediated mechanisms in LNCaP prostate cancer cells P Muthumani, K Alagarsamy, S Dhandayuthapani, T Venkatesan, ... Molecular biology reports 41 (8), 5533-5541 , 2014 2014 Citations: 19
Modulatory effect of Gynandropsis gynandra L. on glucose metabolizing enzymes in aflatoxin B1-induced hepatocellular carcinoma in rats D Sivanesan, VH Begum Indian journal of biochemistry & biophysics 44 (6), 477 , 2007 2007 Citations: 17
Exploring cutting‐edge approaches in anaerobic digestion and anaerobic digestate management I Mariappan, R Prabhakaran, V Vivekanand, MS Poomani, K Muthan, ... ChemBioEng Reviews 11 (3), 573-594 , 2024 2024 Citations: 16
Anti-angiogenic and pro-apoptotic effects of a small-molecule JFD-WS in in vitro and breast cancer xenograft mouse models A Rathinavelu, T Kanagasabai, S Dhandayuthapani, K Alhazzani Oncology Reports 39 (4), 1711-1724 , 2018 2018 Citations: 8
Antioxidant Potential of Aegle marmelos Leaves Against Aflatoxin B1 Induced Liver Toxicity in Rats D Sivanesan, VH Begum Chemical Science 3 (2), 791-795 , 2014 2014 Citations: 7
