Posaconazole loaded bilosomes as a novel vesicular carrier for topical treatment of fungal infections: Formulation, optimization, ex-vivo permeation and antifungal assay Shital Bahadure, Sharvil Patil, Shubham Patil Next Nanotechnology, 2025 Posaconazole (PSZ) is potent drug used in infections caused by Candida, Aspergillus species and many other fungal species. However PSZ belongs to BCS class II limiting its in vivo performance. The objective of current work was to mitigate the difficulties in topical delivery of PSZ overcoming its shortcomings such as aqueous solubility. PSZ loaded bilosomes were prepared and optimized using Box-Behnken design. The optimized bilosomes were characterized by TEM, DSC, FTIR, in vitro PSZ release, ex-vivo skin permeation and antifungal activity against Candida albicans and Aspergillus niger . The optimized spherical, unilamellar batch (PSZ_BIL) of bilosomes had vesicle size of 264.40 ± 5.17 nm and encapsulation efficiency of 97.54 ± 3.5 %. DSC studies revealed solubilization of PSZ in the molten mixture of cholesterol, poloxamer and sodium deoxycholate. FTIR spectra of PSZ_BIL suggested hydrogen bonding between PSZ and poloxamer in bilosomes responsible for greater entrapment efficiency. Further PSZ_BIL showed 2 fold increase in PSZ release when formulated into bilosomes. Ex vivo skin permeation studies showed 2.5 fold higher PSZ retention in rat skin when compared to PSZ gel. Additionally, local accumulation efficiency of PSZ was found to be 2.01 for PSZ_BIL gel formulation. The PSZ_BIL showed 2.33-fold and 1.8 fold increase in zone of inhibition for Candida albicans and Aspergillus niger respectively when compared to PSZ gel. Thus the prepared posaconazole loaded bilosomal gel could be an alternative to the existing formulation demonstrating the antifungal activity at much lower dose of the drug alone.
HME-assisted formulation of taste-masked dispersible tablets of cefpodoxime proxetil and roxithromycin Prathamesh S. Patil, Sushank J. Suryawanshi, Sharvil S. Patil, Atmaram P. Pawar Journal of Taibah University Medical Sciences, 2024 Objectives: Antibiotics are the most commonly administered medications among pediatric patients. However most of the time, accurate dose administration to children becomes a problem due to the extremely bitter taste. Cefpodoxime proxetil (CP) and roxithromycin (ROX) are antibiotics often prescribed to the pediatric population and have a bitter taste. Marketed formulations of these drugs are dry suspension and/or tablets. The lyophilization method involves various steps and thus is time consuming and expensive. The objective of this study was to mask the bitter taste of CP and ROX without compromising the solubility and drug release profile compared to marketed formulations, as well as to overcome the disadvantages associated with the currently used lyophilization technique. Methods: taste-masking efficiency. Results: taste-masking studies. Conclusion: The current work presents solvent-free, scalable, and continuous HME technology for addressing the bitter taste issues of CP and ROX. The disadvantages associated with the currently used lyophilization technique were overcome by developing the formulations using HME technology.
Formulation and Characterization of Folate Receptor-Targeted Quercetagetin-Loaded Mixed Micelles With Enhanced Oral Bioavailability and Anticancer Efficacy Against Human … S Suryawanshi, S Patil BioNanoScience 16 (2), 141 , 2026 2026
Novel Cocrystal of Quercetagetin: In vitro and in vivo Insights into Biopharmaceutical Performance S Suryawanshi, P Shaligram, RG Gonnade, S Patil Pharmaceutical Research, 1-13 , 2026 2026
Simple and Cost-Effective Chrysin-Theophylline Eutectic: Enhanced Solubility, Dissolution, and Oral Bioavailability with Potential for Respiratory Applications S Sirmanwar, S Patil RSC Pharmaceutics , 2026 2026
Linagliptin-loaded bilosomes for oral administration: Formulation, optimization by Box-Behnken design, in-vitro, and in-vivo assessment K Pawar, R Kamble, S Patil Journal of Drug Delivery Science and Technology 108, 106879 , 2025 2025 Citations: 9
Fabrication of chitosan-coated tadalafil nanocrystals by Box-Behnken design to enhance its solubility and oral bioavailability via sonoprecipitation technique M Kale, S Patil, R Kamble Journal of Drug Delivery Science and Technology 106, 106726 , 2025 2025 Citations: 3
Posaconazole loaded bilosomes as a novel vesicular carrier for topical treatment of fungal infections: formulation, optimization, ex-vivo permeation and antifungal assay S Bahadure, S Patil, S Patil Next Nanotechnology 8, 100221 , 2025 2025 Citations: 4
Artesunate-loaded bilosomes with enhanced oral bioavailability: in silico and in vitro study against Leishmania donovani promastigotes and in vivo pharmacokinetic assessment in … H Wankhede, SM Penumaka, D Mandal, S Rojatkar, V Gaikwad, S Patil RSC Pharmaceutics 2 (3), 541-552 , 2025 2025 Citations: 4
HME-assisted formulation of taste-masked dispersible tablets of cefpodoxime proxetil and roxithromycin PS Patil, SJ Suryawanshi, SS Patil, AP Pawar Journal of Taibah University Medical Sciences 19 (2), 252-262 , 2024 2024 Citations: 13
Mitochondria-targeted docetaxel loaded DQAsomes for the treatment of multi-drug resistant breast tumor: In vitro and in vivo studies A Pawar, S Patil, R Kamble Journal of Drug Delivery Science and Technology 92, 105277 , 2024 2024
Fabrication, optimization and characterization of an osmotic push-pull drug delivery system for paliperidone SA Nangare, AH Ali, KR Mahadik, SS Patil Journal of Taibah University Medical Sciences 18 (6), 1511-1518 , 2023 2023 Citations: 6
Formulation of canagliflozin hemihydrate-loaded bilosomes for the treatment of Type-2 diabetes mellitus: In vitro, in vivo and in silico molecular docking studies S Patil, S Bahadure, S Patil Journal of Drug Delivery Science and Technology 86, 104630 , 2023 2023 Citations: 9
Electrospray technology as a probe for single step fabrication of glipizide loaded nanocochleates with enhanced bioavailability A Jain, R Kamble, S Patil Journal of Dispersion Science and Technology 44 (3), 487-495 , 2023 2023 Citations: 10
Rivaroxaban eutectics with improved solubility, dissolution rates, bioavailability and stability PS Shaligram, CP George, H Sharma, KR Mahadik, S Patil, K Vanka, ... CrystEngComm 25 (22), 3253-3263 , 2023 2023 Citations: 17
Hot Melt Extrusion Assisted Felodipine Loaded Liquid Crystal Precursor with Enhanced Solubility and Sustained Drug Release Characteristics S Suryawanshi, R Pawar, R Gonnade, S Patil Analytical Chemistry Letters 12 (6), 745-760 , 2022 2022 Citations: 2
Probing influence of nanocarrier structure on red blood cell membrane perturbations A Jain, S Patil Materials Technology 37 (10), 1338-1345 , 2022 2022
Formulation and evaluation of poly-herbal face pack A Jain, S Patil Allana Management Journal of Research, Pune 12, 19-29 , 2022 2022
Resveratrol loaded cubic phase nanoparticles with enhanced oral bioavailability NK Rawat, A Torris, S Bhat, K Mahadik, S Patil BioNanoScience 11 (4), 1108-1118 , 2021 2021 Citations: 3
Advanced Development of Carboxylic Acid Functionalized Multiwall Carbon Nanotubes as Safe Inhalation Drug Carrier K Dhekale, S Patil, R Kamble Int. J. Pharm. Investing 11 (1), 82 , 2021 2021 Citations: 3
Nanotechnology: Regulatory Outlook On Nanomaterials, Nanomedicines In United States, Europe And India SP Rashi Malik Applied Clinical Research, Clinical Trials and Regulatory Affairs , 2020 2020 Citations: 47
Albendazole electrospun nanofiber films: in-vitro and ex-vivo assessment RN Kamble, RV Mehtre, PP Mehta, P Nangare, SS Patil BioNanoScience 9 (3), 625-636 , 2019 2019 Citations: 18
MOST CITED SCHOLAR PUBLICATIONS
Enhanced oral bioavailability and anticancer activity of novel curcumin loaded mixed micelles in human lung cancer cells KM Sharvil Patil, , , Bhavana Choudhary, Atul Rathore, Krishtey Roy Phytomedicine , 2015 2015 Citations: 126
Fabrication of electrospun nanofibres of BCS II drug for enhanced dissolution and permeation across skin RN Kamble, S Gaikwad, A Maske, SS Patil Journal of advanced research 7 (3), 483-489 , 2016 2016 Citations: 73
Potentiating antimicrobial efficacy of propolis through niosomal-based system for administration J Patel, S Ketkar, S Patil, J Fearnley, KR Mahadik, AR Paradkar Integrative medicine research 4 (2), 94-101 , 2015 2015 Citations: 73
Galangin loaded galactosylated pluronic F68 polymeric micelles for liver targeting S Patil, V Ujalambkar, A Rathore, S Rojatkar, V Pokharkar Biomedicine & Pharmacotherapy 112, 108691 , 2019 2019 Citations: 72
Chrysin-loaded folate conjugated PF127-F68 mixed micelles with enhanced oral bioavailability and anticancer activity against human breast cancer cells D Baidya, J Kushwaha, K Mahadik, S Patil Drug development and industrial pharmacy 45 (5), 852-860 , 2019 2019 Citations: 70
Nanotechnology: Regulatory Outlook On Nanomaterials, Nanomedicines In United States, Europe And India SP Rashi Malik Applied Clinical Research, Clinical Trials and Regulatory Affairs , 2020 2020 Citations: 47
Exploring the potential of electrospray technology in cocrystal synthesis S Patil, J Kulkarni, K Mahadik Industrial & Engineering Chemistry Research 55 (30), 8409-8414 , 2016 2016 Citations: 42
Liquid crystalline phase as a probe for crystal engineering of lactose: carrier for pulmonary drug delivery SS Patil, KR Mahadik, AR Paradkar European Journal of Pharmaceutical Sciences 68, 43-50 , 2015 2015 Citations: 34
Electrospray technology as a probe for cocrystal synthesis: Influence of solvent and coformer structure S Patil, V Ujalambkar, A Mahadik Journal of Drug Delivery Science and Technology 39, 217-222 , 2017 2017 Citations: 33
Green synthesized nanosilver loaded silk fibroin gel for enhanced wound healing KM Sharvil Patil, , Tom George Journal of Drug Delivery Science and Technology , 2015 2015 Citations: 31
Can green synthesized propolis loaded silver nanoparticulate gel enhance wound healing caused by burns? S Patil, N Desai, K Mahadik, A Paradkar European Journal of Integrative Medicine 7 (3), 243-250 , 2015 2015 Citations: 30
Harmine-loaded galactosylated pluronic F68-gelucire 44/14 mixed micelles for liver targeting J Prasad Kushwaha, D Baidya, S Patil Drug Development and Industrial Pharmacy 45 (8), 1361-1368 , 2019 2019 Citations: 29
QbD based approach for optimization of Tenofovir disoproxil fumarate loaded liquid crystal precursor with improved permeability S Patil, C Kadam, V Pokharkar Journal of advanced research 8 (6), 607-616 , 2017 2017 Citations: 29
Synthesis and antibacterial studies of chloramphenicol loaded nano-silver against Salmonella typhi SS Patil, RS Dhumal, MV Varghese, AR Paradkar, PK Khanna Synthesis and reactivity in inorganic, metal-organic, and nano-metal … , 2009 2009 Citations: 28
Rheological investigation and its correlation with permeability coefficient of drug loaded carbopol gel: influence of absorption enhancers PB Pisal, SS Patil, VB Pokharkar Drug development and industrial pharmacy 39 (4), 593-599 , 2013 2013 Citations: 27
Synthesis and in-vitro antimycobacterial studies of cysteine capped silver nano-particles MV Varghese, RS Dhumal, SS Patil, AR Paradkar, PK Khanna Synthesis and reactivity in inorganic, metal-organic, and nano-metal … , 2009 2009 Citations: 27
Electrospray technique for cocrystallization of phytomolecules S Patil, K Chaudhari, R Kamble Journal of King Saud University-Science 30 (1), 138-141 , 2018 2018 Citations: 22
Probing influence of methodological variation on active loading of acetazolamide into nanoliposomes: Biophysical, in vitro, ex vivo, in vivo and rheological investigation PB Pisal, MA Joshi, MN Padamwar, SS Patil, VB Pokharkar International journal of pharmaceutics 461 (1-2), 82-88 , 2014 2014 Citations: 19
Albendazole electrospun nanofiber films: in-vitro and ex-vivo assessment RN Kamble, RV Mehtre, PP Mehta, P Nangare, SS Patil BioNanoScience 9 (3), 625-636 , 2019 2019 Citations: 18
Crystal engineering of lactose using electrospray technology: carrier for pulmonary drug delivery S Patil, A Mahadik, P Nalawade, P More Drug development and industrial pharmacy 43 (12), 2085-2091 , 2017 2017 Citations: 18