Cross-Education Effects After Submaximal and Supramaximal Accentuated Eccentric Loading on Lean Mass and Function in Women Sergio Maroto-Izquierdo, Miguel Lauría-Martínez, Kayvan Khoramipour, Irati Jauregui-Fajardo, Paula Redondo-Delgado, José Antonio de Paz, David García-López Journal of Functional Morphology and Kinesiology, 2026 Objective: This study compared the effects of submaximal and supramaximal accentuated eccentric loading (AEL) on lean mass and function in the trained (TL) and contralateral non-trained (NTL) legs of women. Methods: Twenty recreationally trained women were randomly assigned to submaximal (90% 1-RM) or supramaximal (120% 1-RM) AEL leg press training (2/week, 10 weeks, 4 sets of 8 repetitions) with 30% 1-RM concentric loading. Total thigh lean mass (TTLM), unilateral leg press 1-RM, mechanical power at 40% (P40), 60% (P60), and 80% (P80) of 1-RM, unilateral countermovement (CMJ) and drop jump (DJ) height, and muscle endurance (XRM) were assessed for each leg before and after intervention. Results: Regarding the TL, the submaximal group showed significant (p < 0.05) increases in 1-RM, P40, CMJ, and DJ, while the supramaximal group showed increased TTLM, 1-RM, P40, P60, and XRM. No significant differences were observed between groups. In the NTL, both groups showed significant increases in 1-RM and P40. Additionally, the submaximal group demonstrated improvements in P60, while the supramaximal group showed significant increases in both P60 and P80, and in TTLM. TL and NTL changes correlated significantly for 1-RM, CMJ, and TTLM. However, TL and NTL changes differed significantly for 1-RM and P40 in the submaximal group and for TTLM in the supramaximal group. Conclusions: Submaximal and supramaximal AEL resulted in similar neuromuscular improvements in both TL and NTL in women. Supramaximal loading provided additional benefits in mechanical power lean mass, while submaximal loading improved explosive performance. Supramaximal loading may not be necessary for active women.
Physical exercise and breast cancer-related lymphedema: an umbrella review, systematic review and meta-analysis Celia García-Chico, Susana López-Ortiz, José Pinto-Fraga, Claudia Ceci, Pedro L. Valenzuela, Saúl Peñín-Grandes, Sergio Maroto-Izquierdo, Grazia Graziani, Carmen Fiuza-Luces, Simone Lista, Alejandro Lucia, Alejandro Santos-Lozano Disability and Rehabilitation, 2026 PURPOSE: The present study aimed to summarize the current evidence on the impact of exercise in patients at risk or with breast cancer-related lymphedema (BCRL) through an umbrella review of existing meta-analysis and a systematic review and meta-analysis of randomized controlled trials (RCTs). MATERIAL AND METHODS: A search was conducted in PubMed and Web of Science up to June 2025 to identify meta-analyses and RCTs that included exercise interventions in patients at risk or with BCRL. RESULTS: Three systematic reviews including 14 individual meta-analyses were included in the umbrella review. Two of these met the criteria of strong evidence, reporting beneficial effects of exercise on upper- and lower-body strength. A total of 46 RCTs were included in the systematic review, of which 11 could be meta-analyzed. Strong evidence was found for a beneficial effect of exercise on upper- and lower-body strength and upper-limb disability. CONCLUSION: Strong evidence supports the beneficial effects of exercise on upper- and lower-body strength and upper-limb disability in patients at risk or with BCRL.
From Multi-omics To Personalized Training: The Rise of Enduromics and Resistomics Kayvan Khoramipour, Sergio Maroto-Izquierdo, Simone Lista, Alejandro Santos-Lozano, Katsuhiko Suzuki Sports Medicine Open, 2025 Because of its positive effects on the cardiovascular, metabolic and neurohormonal systems, as well as other aspects of systemic physiology, exercise is crucial to overall health. Traditional exercise physiology techniques that rely on invasive procedures have limited our understanding of the molecular changes induced by exercise. This paper distinguishes the emerging fields of “enduromics” and “resistomics” from sportomics. Enduromics and resistomics concentrate on the molecular responses to endurance and resistance training, respectively, in a variety of populations, whereas sportomics stresses the study of molecular alterations in athletes in competitive or simulated situations. These fields integrate biological systems with omics technology to provide accurate insights into the many physiological responses that occur during aerobic and anaerobic exercise. These methods make it possible to create individualized training plans that maximise health, reduce injury risk and improve adherence by identifying biomarkers and metabolic fingerprints. The revolutionary potential of enduromics and resistomics for athletic performance and public health underscores the need for more research across all demographics and training modalities.
Daily Movement Matters: Post-Exercise Hypotension in Peripheral Arterial Disease—A Quasi-Experimental Pilot Study Saúl Peñín-Grandes, Susana López-Ortiz, Montserrat de la Fuente Gómez, Mª Lourdes del Río-Solá, Sergio Maroto-Izquierdo, Alejandro Santos-Lozano, Juan Martín-Hernández, José Pinto-Fraga Journal of Functional Morphology and Kinesiology, 2025 Background: Aerobic and resistance training have acute effects on blood pressure (BP) in peripheral arterial disease (PAD). However, the combined effect of both exercises in a single session is still unknown. The aim of this study was to analyze the effects of a single exercise session combining walking and circuit-based training on BP in patients with PAD. Methods: Participants with PAD (n = 13; 65.0 ± 10.2 years; 76.9% male) underwent a supervised exercise therapy (SET) intervention (312 sessions, 24 sessions/patient) that included 15–30 min of walking, followed by 15 min circuit-based training. Clinic systolic (SBP) and diastolic (DBP) were recorded 5 min before and after each exercise session. Longitudinal changes were analyzed using repeated-measures analysis of variance (ANOVA) and categorical changes in blood pressure levels were evaluated with chi-square tests. Results: After each exercise session, clinic SBP decreased 4.87 mmHg (p < 0.001) and clinic DBP decreased 2.11 mmHg (p < 0.001). Furthermore, there were no differences between the initial stage of training (1–10 sessions) and late (14–24 sessions) for each time that SBD or DBP were measured. Conclusions: After an acute exercise session, both clinical SBP and DBP decreased in patients with PAD compared to pre-exercise values. However, no additional reductions in clinical BP were observed when comparing early (sessions 1–10) and late (sessions 14–24) stages of the full SET intervention.
Proteomics signatures of human breast cancer: A systematic review Celia García-Chico, Abel Plaza-Florido, Susana López-Ortiz, José Pinto-Fraga, Sergio Maroto-Izquierdo, Kayvan Khoramipour, Lucía Sagarra-Romero, Carmen Fiuza-Luces, Alejandro Lucia, Alejandro Santos-Lozano Critical Reviews in Oncology Hematology, 2025
Current Guidelines for the Implementation of Flywheel Resistance Training Technology in Sports: A Consensus Statement Marco Beato, Kevin L. de Keijzer, Alejandro Muñoz-Lopez, Javier Raya-González, Marco Pozzo, Björn A. Alkner, Antonio Dello Iacono, Jordi Vicens-Bordas, Giuseppe Coratella, Sergio Maroto-Izquierdo, Oliver Gonzalo-Skok, Stuart A. McErlain-Naylor, Fernando Martin-Rivera, Jose L. Hernandez-Davo, Luis Suarez Arrones, Rafael Sabido, Moises de Hoyo, Rodrigo Fernandez-Gonzalo, Lena Norrbrand Sports Medicine, 2024
The relative age effect in the 10 best leagues of male professional football of the union of european football associations (UEFA) Journal of Sports Science and Medicine, 2018