Long non-coding RNA FAM83H-AS1 as an emerging marker for diagnosis, prognosis and therapeutic targeting of cancer Nahla E. El‐Ashmawy, Ghada M. Al‐Ashmawy, Sara M. Hamouda Cell Biochemistry and Function, 2021 Incidence and mortality rates of cancer continue to increase greatly despite the improved diagnostic and therapeutic methods. Based on GLOBOCAN estimates, the numbers of new cancer cases reported in 2018 were ~18.1 million, while the numbers of cancer mortalities were ~9.6 million. It remains difficult to diagnose most cancer patients at early stages. Although cancer therapy market is rapidly evolving, the effectiveness of therapy is still inadequate. Therefore, exploring new biomarkers for diagnosis, prognosis and treatment is essential for cancer management. Long non‐coding RNAs (lncRNAs) are unique regulatory molecules that control several cellular processes and are implicated in diverse human diseases including cancer. LncRNAs could serve as potential biomarkers for cancer patients to aid diagnosis and determine prognosis. In addition, numerous lncRNAs have proved their ability to predict response to cancer treatment. FAM83H antisense RNA 1 (FAM83H‐AS1) is among those highly dysregulated lncRNAs in cancer. FAM83H‐AS1 was demonstrated to participate in the progression of different malignancies and also shown to play a vital role in diagnosis, prognosis and treatment. Here, we analyse recent studies concerning the oncogenic role and molecular mechanisms of lncRNA FAM83H‐AS1 in the following cancer types: bladder, breast, lung, hepatocellular, colorectal, gastric, pancreatic, ovarian, cervical cancer as well as glioma.
Identification of lncRNA ZNF252P-AS1 as a novel diagnostic and prognostic biomarker for breast cancer patients: An integrated bioinformatics and experimental analysis NE El-Ashmawy, MA Abo-Saif, SM Hamouda, EG Khedr Clinica Chimica Acta, 120746 , 2025 2025
Cuproptosis regulation by long noncoding RNAs: Mechanistic insights and clinical implications in cancer NE El-Ashmawy, EG Khedr, MA Abo-Saif, SM Hamouda Archives of Biochemistry and Biophysics 765, 110324 , 2025 2025 Citations: 6
Long noncoding RNAs as regulators of epithelial mesenchymal transition in breast cancer: A recent review NE El-Ashmawy, EG Khedr, MA Abo-Saif, SM Hamouda Life Sciences 336, 122339 , 2024 2024 Citations: 11
Evaluation of the use of long noncoding RNAs as biomarkers for diagnosis of breast cancer: Thesis Abstract N El-Ashmawy, F Zakaria, G Al-Ashmawy, SM Hamouda Egyptian Journal of Cancer and Biomedical Research 5 (1.1), 20-20 , 2021 2021
Long non‐coding RNA FAM83H‐AS1 as an emerging marker for diagnosis, prognosis and therapeutic targeting of cancer NE El‐Ashmawy, GM Al‐Ashmawy, SM Hamouda Cell Biochemistry and Function 39 (3), 350-356 , 2021 2021 Citations: 14
Serum LncRNA-ATB and FAM83H-AS1 as diagnostic/prognostic non-invasive biomarkers for breast cancer NE El-Ashmawy, FZ Hussien, OA El-Feky, SM Hamouda, GM Al-Ashmawy Life Sciences 259, 118193 , 2020 2020 Citations: 62
MOST CITED SCHOLAR PUBLICATIONS
Serum LncRNA-ATB and FAM83H-AS1 as diagnostic/prognostic non-invasive biomarkers for breast cancer NE El-Ashmawy, FZ Hussien, OA El-Feky, SM Hamouda, GM Al-Ashmawy Life Sciences 259, 118193 , 2020 2020 Citations: 62
Long non‐coding RNA FAM83H‐AS1 as an emerging marker for diagnosis, prognosis and therapeutic targeting of cancer NE El‐Ashmawy, GM Al‐Ashmawy, SM Hamouda Cell Biochemistry and Function 39 (3), 350-356 , 2021 2021 Citations: 14
Long noncoding RNAs as regulators of epithelial mesenchymal transition in breast cancer: A recent review NE El-Ashmawy, EG Khedr, MA Abo-Saif, SM Hamouda Life Sciences 336, 122339 , 2024 2024 Citations: 11
Cuproptosis regulation by long noncoding RNAs: Mechanistic insights and clinical implications in cancer NE El-Ashmawy, EG Khedr, MA Abo-Saif, SM Hamouda Archives of Biochemistry and Biophysics 765, 110324 , 2025 2025 Citations: 6
Identification of lncRNA ZNF252P-AS1 as a novel diagnostic and prognostic biomarker for breast cancer patients: An integrated bioinformatics and experimental analysis NE El-Ashmawy, MA Abo-Saif, SM Hamouda, EG Khedr Clinica Chimica Acta, 120746 , 2025 2025
Evaluation of the use of long noncoding RNAs as biomarkers for diagnosis of breast cancer: Thesis Abstract N El-Ashmawy, F Zakaria, G Al-Ashmawy, SM Hamouda Egyptian Journal of Cancer and Biomedical Research 5 (1.1), 20-20 , 2021 2021