Professor Samah Sayed Mehanny is a course coordinator of the Oral Biology department in the Dentistry field at Gu, with Ph.D. in Oral Biology from Cairo University. Before joining GU, Professor Samah was the former head of the oral biology department, Faculty of Dentistry, Future University, and a course coordinator (dental anatomy), Faculty of Dentistry, Cairo University. Professor Samah is trying to correlate basic science with clinical studies.
RESEARCH, TEACHING, or OTHER INTERESTS
Dentistry, General Dentistry
FUTURE PROJECTS
student self assessment application based on Artificial intelligence for dental students
Applications Invited collaboration with AI specialists
15
Scopus Publications
442
Scholar Citations
6
Scholar h-index
5
Scholar i10-index
Scopus Publications
The evolving landscape of oral biology education: a comparative study of teaching strategies Israa Ahmed Radwan, Sara El Moshy, Dina Rady, Nahed Sedky Korany, Fatma A. N. Abouel Maaty, et al. BMC Medical Education, 2025 Background With the enormous changes in dental education to prepare well-trained dentists for future requirements, little is known about students’ feedback and their perceptions of their curriculum. With respect to academic progress, bridging the gap between basic biological sciences and clinical studies has recently become one of the prominent approaches. However, the perspectives of medical students are not frequently considered during the revision of the medical curriculum. This study aims to investigate the influence of different oral biology and embryology teaching strategies on dental students’ clinical awareness and practices. Methods This cross-sectional study provided a structured and anonymous online questionnaire to at least 222 currently registered dental students and dental alumni from various Egyptian universities. The questions referred to oral biology teaching methods, clinical relevance, the use of virtual microscopes, and the associations of oral biology and embryology with other subjects in the dental curriculum. The answers were collected, and the data were statistically analyzed. Results According to data, students strongly preferred modern teaching techniques over traditional ones, such as 3D holography and virtual microscopy. Most participants from both national and private universities expressed a strong preference for modern teaching techniques. The majority of participants in the study also concurred that oral biology topics are pertinent to clinical decision-making. Conclusion By incorporating innovative technologies such as digital scanned slides, virtual microscopy, and holography, dental institutions can boost the educational process, especially the online process, and equip future dentists with essential skills for clinical excellence. Perpetual evaluation of teaching strategies is crucial for optimizing student engagement and ensuring the effectiveness of these advancements.
Mitochondrial dysfunction as a key player in aggravating periodontitis among diabetic patients: review of the current scope of knowledge Al-Hassan Soliman Wadan, Ahmed Sherief Moshref, Abdullah Mohammed Emam, Youssef Gamal Bakry, Bushra Osama Khalil, et al. Naunyn Schmiedeberg S Archives of Pharmacology, 2025 Periodontitis is a prevalent inflammatory disease that leads to significant periodontal tissue destruction and compromised dental health, with its severity exacerbated in individuals with Diabetes Mellitus (DM). This review explores the complex relationship between mitochondrial dysfunction and periodontitis in diabetic patients. Recent studies indicate that the excessive production of reactive oxygen species (ROS), primarily generated by dysfunctional mitochondrial electron transport chain (ETC) complexes, contributes to oxidative stress (OS) and subsequent periodontal tissue damage. The interplay between impaired mitochondrial biogenesis, apoptosis of periodontal cells, and ROS accumulation highlights a critical area of concern in understanding the pathophysiology of diabetic periodontitis. Furthermore, altered glycemic control due to inflammatory processes associated with periodontitis may perpetuate a cyclical detriment to oral and systemic health. This review aims to highlight the mechanistic roles of mitochondrial dysfunction in the aggravation of periodontitis among diabetic patients, emphasizing further research to identify potential therapeutic targets and improve treatment efficacy for this dual pathology.
Histological and Molecular Assessment of Bone Regenerative Potential of Human Dental Pulp Stem Cells’Secretome on Rabbits’ Tibial Bone Defects Lobna Salah Eldin, Dina Rady, Nermeen Ahmed, Samah Mehanny Egyptian Journal of Histology, 2024 Introduction: Bone fractures are a global public health burden as there are more than 150 million bone fracture incidence per year. The therapeutic effect of mesenchymal stem cells (MSCs) is mediated by the secretion and release of trophic molecules, which are called ‘secretome’. There are only a handful of studies that evaluated the effect of dental MSCs-derived secretome in bone healing and regeneration. Aim of Study: This study was designed to investigate the regenerative potential of human dental pulp stem cells’ (hDPSCs’) secretome on rabbits’ tibial bone defects at three-and six-weeks follow-ups. Materials and Methods: 42 rabbits received 84 six-mm-diameter tibial bone defects; 21 for each outcome; 7 defects for each group per each time interval. Bone defects were either left to heal spontaneously (Group A) or received either collagen scaffold (Group B) or hDPSCs’ secretome loaded on collagen scaffold (Group C). Animals were euthanized at three and six weeks. Histomorphometric evaluation of newly formed bone area percent and degree of bone maturation using Hematoxylin and Eosin (H&E) and Masson Trichrome (MT) stains respectively was constructed in addition to quantitative real time polymerase chain reaction (qRT-PCR) to evaluate osteocalcin levels. Results: Histomorphometric analysis of H&E-& MT-stained sections showed significant increase in bone area percent as well as bone maturation in the group C in comparison to the other two groups ( P < 0.05) at both time intervals. qRT-PCR results supported our abovementioned results as they showed that osteocalcin levels were higher in group C as compared to the other two groups at both time intervals ( P <0.05). Conclusions: hDPSCs’ secretome showed superior results and significant improvement of bone healing.
Dental Disease Detection based on CNN for Panoramic Dental Radiographs Manar El Bagoury, Mirna Al-Shetairy, Omar Ahmed, Samah S Mehanny, Tassneem Hamdy, et al. Proceedings 11th IEEE International Conference on Intelligent Computing and Information Systems Icicis 2023, 2023 Panoramic dental radiography is one of the examination tools frequently performed in dental clinics and hospitals as it captures a wide range of the dental region and its surroundings, but due to the complex structure of the dental area and lack of time, dentists focus on tiny parts of the images. With the help of Machine Learning, dentists can detect dental defects and anomalies faster and more accurately. In this study, a data set of 733 panoramic radiographs of adult patients was collected from the faculty of Oral and Dental Medicine, Future University, Egypt. Using a combination of pre-trained CNN architecture and a finetuned network, the collected panoramic radiographs were used to determine the optimal architecture. The purpose of this research was to develop a computer-aided detection system based on a finetuned CNN algorithm, and to evaluate the accuracy and usefulness of this system for the detection of proximal and occlusal caries, interdental and inter radicular alveolar bone loss, periapical lesions, and impacted teeth in panoramic radiographs. Different object detection models were tested to detect selected dental diseases that were found in the panoramic radiographs, and after a few experiments, the YOLOv5 architecture was proved to be the most optimal after achieving 0.61 mAP@0.5 and 0.28 mAP@ [0.5-0.95] for the total six classes. This is the best-achieved results to our knowledge.
Evaluation of the Effects of One versus 4 Weeks Activation Intervals on the Rate of Orthodontic Tooth Movement: An Experimental Study Mahmoud Elseidy, Yehya A. Mostafa, Sammah S. Mehanni, Fouad A. El-Sharaby Open Access Macedonian Journal of Medical Sciences, 2022 Objectives: To evaluate the effects of one versus four weeks reactivation of the elastomeric chain on the rate of orthodontic tooth movement (OTM) and supporting structures.
 Methods: The 3rd maxillary premolars of 8 male mongrel dogs were extracted. Custom made appliance was constructed so that the 2nd premolars were allowed to slide bodily. An elastomeric chain with calibrated force of 150g was attached to the hooks of soldered tubes on the 2nd premolar’s crowns. The sample was divided into two groups based on the interval of reactivation of the elastomeric chains used for tooth movement where in group I activation was scheduled every one week versus four weeks in group II. Measurements of the amount and rate of OTM were performed every week for 12 weeks using digital caliper. The animals were then sacrificed and specimens were prepared for decalcified histological examination using Hematoxylin and Eosin stains under light microscope.
 Results: No remarkable difference in the rate of OTM between the two groups was reported. The total amount of tooth movement in group I was 1.44mm ± 0.5 compared to 1.46mm ± 0.6 in group II. Histological examination revealed a more favorable tissue reaction associated with 4 weeks reactivation as regards the new formed bone, root resorption and periodontal ligament structure.
 Conclusion: Altering the reactivation interval of the elastomeric chains from four to one week doesn’t have a significant impact on the rate of OTM. However, four weeks reactivation interval showed a more favorable tissue reaction associated with orthodontic tooth movement.
Extra hepatic effects of sofosbuvir on a serous model of major and minor salivary glands in albino rats Fatma Saad, Iman Aboushady, Samah Mehanni Egyptian Journal of Histology, 2020 Background: Extra hepatic adverse effects associated with the therapy of chronic HCV infection with sofosbuvir treatment regimens have recently arisen.Objective: This study aimed to assess the inflammatory effect of sofosbuvir and its influence on cellular proliferation, functionality and differentiation of both submandibular (SMGs) and Von Ebner's salivary glands (EGs).Methodology: 21 adult male albino rats were divided into three equal groups: GroupI (control) received orally distilled water; GroupII received orally sofosbuvir (40 mg/kg/day) dissolved in distilled water for one month and GroupIII received sofosbuvir for 2 months. SMGs and EGs sections were processed for HE shrunken acini, glandular cell vacuolization, nuclear degenerative signs, wide degenerative stromal areas and flattening of excretory ductal lining with stagnant secretion as well as the transformation of few serous glandular cells into mucous-like cells particularly in SMGs of groupIII. Likewise, both glands of groupIІ showed significantly increased immunoreactivity to COX-2 in acini and some ductal cells but with a significant decrease in those of groupIII. Regarding PCNA immunoreactivity and α-amylase immunofluorescence, significantly diminished positivity in the glandular cells of both glands in groupII was detected compared to control group whilst insignificant improvement was elucidated in those of groupIII comparing to groupII except for the significant reactivity to α-amylase in EGs of groupIII.Conclusions: It was concluded that the oxidative stress associated degenerative changes caused by sofosbuvir in salivary glands after one month of administration seemed to be diminished after two months of administration due to the body acquired drug tolerance to restore the disturbed physiological processes. Hence, the use of anti-oxidants as an adjuvant treatment could be beneficial.
Histopathological alterations of the intrinsic tongue muscles following zoledronic acid treatment in a rat model Dina Farag, Samah Mehanny Dental and Medical Problems, 2020 BACKGROUND Bisphosphonates (BPs) are widely used as anti-bone-resorptive agents. Despite the great benefits of BPs, they may cause local and systemic adverse side effects. OBJECTIVES The aim of this study was to evaluate the histopathological effect zoledronic acid (ZA), which belongs to BPs, has on the intrinsic tongue muscles in a rat model. MATERIAL AND METHODS A total of 30 adult male albino rats were divided into 3 groups (10 rats each): group I served as a control; group II was given an intraperitoneal (i.p.) injection of 0.2 mg/kg of ZA once per week for 3 weeks; and group III received the same dosage of ZA, but for 8 weeks. After the animals were euthanized, the tongue tissue was dissected and examined histologically, histochemically and immunohistochemically. RESULTS Histologically, a normal architecture of the muscle fascicles was observed in the control group. Group II showed degenerated muscle fibers with an indistinct sarcolemma. In group III, the muscle fibers were degenerated with severe sarcoplasmic dissolution. The histochemical examination using Masson's trichrome (MT) demonstrated a significant increase in collagen fibers in groups II and III as compared to the control group. The immunohistochemical results revealed a statistically significantly higher expression of nuclear factor kappa B (NF‑κB) in the ZA-treated groups (II and III) as compared to the control group, with the highest mean value recorded in group III. CONCLUSIONS Zoledronic acid induced histopathological changes to the intrinsic tongue muscles, and this effect was exaggerated with a longer duration of administration.
Immediately loaded mini screws: histological study of the effect of two different orthodontic tooth movement techniques. Progress in Orthodontics, 2009
Artificial intelligence fosters forensic odontology-a narrative review AM Gaber, AHS Wadan, N Ammar, V Surya, SS Mehanny, M Abuelhamed, ... Egyptian Journal of Forensic Sciences 16 (1), 35 , 2026 2026
Mitochondrial dysfunction as a key player in aggravating periodontitis among diabetic patients: review of the current scope of knowledge AHS Wadan, AS Moshref, AM Emam, YG Bakry, BO Khalil, A Chaurasia, ... Naunyn-schmiedeberg's Archives of Pharmacology 398 (10), 13173-13204 , 2025 2025 Citations: 7
Mitochondrial-based therapies for neurodegenerative diseases: a review of the current literature AHS Wadan, AH Shaaban, MZ El-Sadek, SA Mostafa, AS Moshref, ... Naunyn-schmiedeberg's Archives of Pharmacology 398 (9), 11357-11386 , 2025 2025 Citations: 34
Cell-Free bone regeneration using dental MSCs secretomes from pulp and gingiva in rabbit tibial defects D Kamal, D Rady, S El Moshy, IA Radwan, NEMB Ahmed, AHS Wadan, ... Scientific Reports 15 (1), 31722 , 2025 2025 Citations: 2
The evolving landscape of oral biology education: a comparative study of teaching strategies IA Radwan, S El Moshy, D Rady, NS Korany, FANA Maaty, FI Elfaiedi, ... BMC Medical Education 25 (1), 779 , 2025 2025 Citations: 3
Histological and Molecular Assessment of Bone Regenerative Potential of Human Dental Pulp Stem Cells’ Secretome on Rabbits’ Tibial Bone Defects LM Salah Eldin, D Rady, NEB Ahmed, S Mehanny Egyptian Journal of Histology 47 (3), 1218-1229 , 2024 2024
Dental Disease Detection based on CNN for Panoramic Dental Radiographs ME Bagoury, M Al-Shetairy, O Ahmed, T Hamdy, M Akram, H Amr, ... Eleventh International Conference on Intelligent Computing and Information … , 2023 2023 Citations: 4
Evaluation of the regenerative potential of human gingival mesenchymal stem cells’ secretome in rabbits’ tibial bone defects SSM Dina Kamal, Sara El Moshy, Nermeen EB Ahmed Egyptian Journal of Histology , 2023 2023
Evaluation of the Effects of One versus 4 Weeks Activation Intervals on the Rate of Orthodontic Tooth Movement: An Experimental Study FAES Mahmoud Elseidy, Yehya A. Mostafa, Sammah S. Mehanni open Access Macedonian Journal of Medical Sciences. 19 (10(D)), 98-103. , 2022 2022 Citations: 4
Extra hepatic effects of sofosbuvir on a serous model of major and minor salivary glands in albino rats FA Saad, I Aboushady, S Mehanni Egyptian Journal of Histology 43 (1), 325-339 , 2020 2020 Citations: 3
The Effect of Bisphosphonates’ Oncologic dose on the Static and Dynamic Bone Parameters of the Temporomandibular Joint’s Condyle (A Randomized Animal Controlled Trial) I Radwan, S Mehanny, MM Abbass Journal of Chemical Health Risks , 2020 2020 Citations: 2
Histopathological alterations of the intrinsic tongue muscles following zoledronic acid treatment in a rat model Zmiany histopatologiczne wewnętrznych mięśni języka szczura po … DB FaragA, SS MehannyA Dent Med Probl 57 (2), 2 , 2020 2020
• Histopathological alterations of the intrinsic tongue muscles following zoledronic acid treatment in a rat model. SSM Dina Badawy Farag 1 Dent Med Probl. 57 (2), 131-136. , 2020 2020 Citations: 2
The effect of bisphosphonates’ oncologic dose on the static and dynamic bone parameters of the temporomandibular joint’s condyle (A randomized animal controlled trial) MMSA Israa A Radwan1 , Samah Mehanny2 Journal of Chemical Health Risks 10, 297-313 , 2020 2020 Citations: 2
Stem Cells and Their Potential Effect on Irradiated Submandibular Salivary Glands in Mice SIH 1, MH Farid2, SS Mehanny3, HFA Hamid4 Al-Azhar Dental Journal for Girls 7 (1), Page 31-39 , 2020 2020
EVALUATION OF THE HISTOPATHALOGICAL CHANGES IN SUBMANDIBULAR SALIVARY GLANDS OF ALBINO RATS UNDER ZOLEDRONIC ACID TREATMENT (ZOMETA)(AN ANIMAL STUDY) MN Sabet, SS Mehanni, DBE Farag, H Gobran DENTAL JOURNAL 63 (1377), 1388 , 2017 2017
Effect of platelet‐rich plasma on orthodontic tooth movement in dogs A Rashid, FA ElSharaby, EM Nassef, S Mehanni, YA Mostafa Orthodontics & Craniofacial Research 20 (2), 102-110 , 2017 2017 Citations: 90
• Evaluation of the histopathalogical changes in submandibular salivary glands of Albino rats under Zoledronic Acid treatment (Zometa) (An Animal study) DF Mina Sabet, Samah S Mehanny Egyptian Dental Journal 63, 1377:1388 , 2017 2017
New approach of bone marrow-derived mesenchymal stem cells and human amniotic epithelial cells applications in accelerating wound healing of irradiated albino rats SS Mehanni, NF Ibrahim, AR Hassan, LA Rashed International journal of stem cells 6 (1), 45 , 2013 2013 Citations: 32
The ameliorative role of grape seed oil on irradiated rat fungiform papillae. SS Mehanni, EM El-Maghraby, AR Hassan, DAH El-Baz 2012
MOST CITED SCHOLAR PUBLICATIONS
Comparison of corticotomy-facilitated vs standard tooth-movement techniques in dogs with miniscrews as anchor units YA Mostafa, MMS Fayed, S Mehanni, NN ElBokle, AM Heider American Journal of Orthodontics and Dentofacial Orthopedics 136 (4), 570-577 , 2009 2009 Citations: 174
Effect of platelet‐rich plasma on orthodontic tooth movement in dogs A Rashid, FA ElSharaby, EM Nassef, S Mehanni, YA Mostafa Orthodontics & Craniofacial Research 20 (2), 102-110 , 2017 2017 Citations: 90
Evaluation of socket healing in irradiated rats after diode laser exposure (histological and morphometric studies) NS Korany, SS Mehanni, HM Hakam, EMF El-Maghraby Archives of oral biology 57 (7), 884-891 , 2012 2012 Citations: 75
Mitochondrial-based therapies for neurodegenerative diseases: a review of the current literature AHS Wadan, AH Shaaban, MZ El-Sadek, SA Mostafa, AS Moshref, ... Naunyn-schmiedeberg's Archives of Pharmacology 398 (9), 11357-11386 , 2025 2025 Citations: 34
New approach of bone marrow-derived mesenchymal stem cells and human amniotic epithelial cells applications in accelerating wound healing of irradiated albino rats SS Mehanni, NF Ibrahim, AR Hassan, LA Rashed International journal of stem cells 6 (1), 45 , 2013 2013 Citations: 32
Mitochondrial dysfunction as a key player in aggravating periodontitis among diabetic patients: review of the current scope of knowledge AHS Wadan, AS Moshref, AM Emam, YG Bakry, BO Khalil, A Chaurasia, ... Naunyn-schmiedeberg's Archives of Pharmacology 398 (10), 13173-13204 , 2025 2025 Citations: 7
Dental Disease Detection based on CNN for Panoramic Dental Radiographs ME Bagoury, M Al-Shetairy, O Ahmed, T Hamdy, M Akram, H Amr, ... Eleventh International Conference on Intelligent Computing and Information … , 2023 2023 Citations: 4
Evaluation of the Effects of One versus 4 Weeks Activation Intervals on the Rate of Orthodontic Tooth Movement: An Experimental Study FAES Mahmoud Elseidy, Yehya A. Mostafa, Sammah S. Mehanni open Access Macedonian Journal of Medical Sciences. 19 (10(D)), 98-103. , 2022 2022 Citations: 4
• Histochemical study on the possible effect of acetyl salicylic acid (Aspirin) on the percentage of survival cells in salivary glands of irradiated rat. M Samah, F Mona, EM Eman Egyptian Dental Journal. 52, 1297-1312 , 2006 2006 Citations: 4
The evolving landscape of oral biology education: a comparative study of teaching strategies IA Radwan, S El Moshy, D Rady, NS Korany, FANA Maaty, FI Elfaiedi, ... BMC Medical Education 25 (1), 779 , 2025 2025 Citations: 3
Extra hepatic effects of sofosbuvir on a serous model of major and minor salivary glands in albino rats FA Saad, I Aboushady, S Mehanni Egyptian Journal of Histology 43 (1), 325-339 , 2020 2020 Citations: 3
Immediately loaded mini screws: histological study of the effect of two different orthodontic tooth movement techniques MM Fayed, S Mehanni, NN Elbokle, YA Mostafa Progress in Orthodontics 10 (2), 38-46 , 2009 2009 Citations: 3
Stem Cells and Their Potential Effect on Irradiated Submandibular Salivary Glands in Mice S Hallool, M Farid, S Mehanny, H Abdel Hamid Al-Azhar Journal of Dentistry 7 (1), 31-39 , 2000 2000 Citations: 3
Cell-Free bone regeneration using dental MSCs secretomes from pulp and gingiva in rabbit tibial defects D Kamal, D Rady, S El Moshy, IA Radwan, NEMB Ahmed, AHS Wadan, ... Scientific Reports 15 (1), 31722 , 2025 2025 Citations: 2
The Effect of Bisphosphonates’ Oncologic dose on the Static and Dynamic Bone Parameters of the Temporomandibular Joint’s Condyle (A Randomized Animal Controlled Trial) I Radwan, S Mehanny, MM Abbass Journal of Chemical Health Risks , 2020 2020 Citations: 2
• Histopathological alterations of the intrinsic tongue muscles following zoledronic acid treatment in a rat model. SSM Dina Badawy Farag 1 Dent Med Probl. 57 (2), 131-136. , 2020 2020 Citations: 2
The effect of bisphosphonates’ oncologic dose on the static and dynamic bone parameters of the temporomandibular joint’s condyle (A randomized animal controlled trial) MMSA Israa A Radwan1 , Samah Mehanny2 Journal of Chemical Health Risks 10, 297-313 , 2020 2020 Citations: 2
Artificial intelligence fosters forensic odontology-a narrative review AM Gaber, AHS Wadan, N Ammar, V Surya, SS Mehanny, M Abuelhamed, ... Egyptian Journal of Forensic Sciences 16 (1), 35 , 2026 2026
Histological and Molecular Assessment of Bone Regenerative Potential of Human Dental Pulp Stem Cells’ Secretome on Rabbits’ Tibial Bone Defects LM Salah Eldin, D Rady, NEB Ahmed, S Mehanny Egyptian Journal of Histology 47 (3), 1218-1229 , 2024 2024
Evaluation of the regenerative potential of human gingival mesenchymal stem cells’ secretome in rabbits’ tibial bone defects SSM Dina Kamal, Sara El Moshy, Nermeen EB Ahmed Egyptian Journal of Histology , 2023 2023