SAI KISHORE VANKAYALAPATI

is working as HOD,Dept of pharmaceutics, of Bapatla College of Pharmacy Bapatla, Andhra Pradesh. He holds a Master and Doctoral degree in pharmaceutics and has 21 years of teaching experience. He has published 134 research papers in peer reviewed national and international journals and has guided 64 students for their M.Pharm dissertation. He also guiding 5 student for their Doctoral degree. He is the life member of The Association of Pharmaceutical Teachers of India. He has done his doctoral thesis on “Design and Development of Transdermal Films for Antihypertensive Drugs”. He has also participated and presented his research works in various national and international conferences. He is the one of the faculty member who participated in the preparation of e-Lessons for the Department of Technical Education, Government of Andhra Pradesh to improve the quality of education in Polytechnics. He is author of three books .

EDUCATION

MPharm., Ph.D

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science, Drug Discovery, Pharmacology, Toxicology and Pharmaceutics, General Pharmacology, Toxicology and Pharmaceutics

Scopus Publications

Design, Development and In vivo Evaluation of Core in Cup Tablets of Budesonide
Swalin Parija, Guru Prasad Mohanta, Upendra Nath Nanda, V. Saikishore
Research Journal of Pharmacy and Technology, 2022
Budesonide is widely used drug for treatment of active inflammatory bowel disease (IBD). Core in-cup tablets were prepared to achieve a prolonged release of Budesonide and for alleviating the symptoms of inflammatory bowel disease. The objective of this study was to investigate differences in the pharmacokinetic patterns between an optimized core in cup tablet formulation and pure Budesonide suspension. In-vivo evaluation studies were performed based on the uniform and reliable results of in-vitro drug release studies. Various pharmacokinetic parameters were compared to obtain mean plasma drug concentration curve versus time. The pure drug suspension and Core-in-cup tablets formulation of Budesonide were administered to two groups of white New Zealand rabbits (n=6) through the oral route following cross over design pattern. The drug concentration in plasma samples were measured using LC-MS/MS method. Pharmacokinetic parameters were determined for each formulation. The comparison of the plasma time curves of the dosage forms showed that each dosage form caused significant differences in the drug plasma levels. The optimized core in cup tablet formulation shown some lag phase initially before releasing the drug. The mean residence time of core in cup tablet formulation was found to be more than the pure drug suspension formulation. The oral administration of Budesonide resulted in a low and quite variable AUC of 154.1±1.44 ng/ml/hr., whereas the optimized core-in-cup tablets resulted in AUC of 918.2±3.11 ng/ml/hr. The bioavailability of optimized formulation was enhanced six times compared with pure drug suspension. From the above results, it can be concluded that the prepared core in cup tablet can be considered as one of the promising formulation techniques for chronotherapeutic management of inflammatory bowel disease.
Design, Development and In Vivo Evaluation of Core in Cup Tablets of Azathioprine
Current Trends in Biotechnology and Pharmacy, 2021
Comparative in vivo evaluation of marketed sustained release and optimized pulsatile formulation of propranolol hydrochloride
Vamsi krishan B, Babu rao CH, Saikishore V
International Journal of Research in Pharmaceutical Sciences, 2020
Chrono pharmaceutical drug delivery system is devoted to the availability of active on a pace that idyllically matches biological requisite of disease treatment. It embodies time controlled and site-specific drug delivery systems, subsequently optimizing therapeutic action and lessening side-effect’s. In the present study optimized pulsatile formulation of Propranolol Hydrochloride ought to deliver drug at pre-set pattern at right time and site is evaluated for pharmacodynamic and pharmacokinetic performance after oral administration and compared with an existing marketed sustained formulation of Propranolol Hcl. The study was carried out in male New Zealand albino rabbits through cross over design pattern and levels of plasma measured by means of LC-MS/MS method. Pharmacokinetic parameters of designed pulsatile formulation was measured and observed to have statistical significance with existing marketed sustained formulation. The In-house pulsatile dosage form able to show lag phase and the mean residence time of pulsatile dosage form (23.20.14h.) was found to be beyond the marketed sustained dosage form (14.8 0.01h.). Pharmacokinetic data revealed a maximum guard against adrenaline levels at 6 h post oral intake and dropped to 50% after 12 h with Marketed formulation. Whereas in case of pulsatile formulation administration a maximum protection was obtained at 12 h. and continued over a period of 18 h. It is concluded that the designed pulsatile formulation offers a promising way of drug release for a programmed time period at desired site, once the administration time and pulse time are aligned with circadian pattern.
Design and characterization of pulsatile drug delivery of losartan potassium
Der Pharmacia Lettre, 2016
Design and development of controlled release tablets of deflazocort
Research Journal of Pharmaceutical Biological and Chemical Sciences, 2014
Design and charecterisation of anastrazole loaded chitosan nanoparticles by ionotropic gelation method
Research Journal of Pharmaceutical Biological and Chemical Sciences, 2014
Design and development of press coated prasugrel hydrochloride tablets for pulsatile drug delivery system
Research Journal of Pharmaceutical Biological and Chemical Sciences, 2014
Design and charecterisation of anastrazole loaded chitosan nanoparticles by emulsification crosslinking
Research Journal of Pharmaceutical Biological and Chemical Sciences, 2014
Formulation and in-vitro characterisation of fast disintegrating tablets of ziprosidone
Research Journal of Pharmaceutical Biological and Chemical Sciences, 2013
Formulation and evaluation of Ramipril SR matrix tablets by using tamrindus kernal mucilage as release retardent
Research Journal of Pharmaceutical Biological and Chemical Sciences, 2013
An overview on combinatorial chemistry
Research Journal of Pharmacy and Technology, 2012
A review on novel approach in gastro retentive floating drug delivery: Floating microspheres
Research Journal of Pharmaceutical Biological and Chemical Sciences, 2012

RECENT SCHOLAR PUBLICATIONS

Fast Dissolving Tablets: Formulation Strategies, Disintegration Mechanisms, and Emerging Innovations
PS V. Saikishore ,M. Ramireddy, C. H.Bhargavi, G. Chandhini, V. Nithin Reddy
International Journal of Scientific Research and Technology 3 (2), 36-45 , 2026
2026
An extended sustained pulsatile drug delivery dosage formulation for chronotherapy
TV B.Vamsi krishna,V.Saikishore
IN Patent 555,015 , 2025
2025
Spherical Agglomeration Techniques in Pharmaceutical Particle Engineering .A Comprehensive Deep-Dive Review for Modern Solid Dosage Form Development.
VNR V.Saikishore , P.Sarnya,CH.Bharghavi , G.Chandhini, M.Ramireddy
Indo-American Journal of Pharmaceutical sciences 12 (12), 520-523 , 2025
2025
Psoralea Corylifolia L. (Bakuchi): A Comprehensive Review on Pharmacognosy, Phytochemistry, Pharmacology, and Therapeutic Potential in Skin Disorders
SUL V. Saikishore, V. Alekhya
Indo-American Journal of Pharmaceutical sciences 12 (11), 947-953 , 2025
2025
Transdermal Drug Delivery System
V Saikishore
Pharmaceutical Techniques in Drug Delivery 1, 182-216 , 2025
2025
A Review Article on Plumeria Alba .; 11 (12):947-953
VSSKA Khan
Indo-American Journal of Pharmaceutical sciences 11 (12), 947-953 , 2024
2024
A Review Article on Crinum Asiaticum
VSMH sai
Indo-American Journal of Pharmaceutical sciences 11 (12), 328-337 , 2024
2024
Review Article of Bhringraj
VSM Nagambika
Indo-American Journal of Pharmaceutical sciences 11 (12), 270-276 , 2024
2024
Medicinal Values of Gomutra: A Review
VSJU Sri
Indo-American Journal of Pharmaceutical sciences 11 (12), 93-101 , 2024
2024
A Review based on drug repurposing: an virtual Tool in modern drug discovery
VSR Sanmathi
Indo-American Journal of Pharmaceutical sciences 11 (12), 81-92 , 2024
2024
Cosmetics and their toxicological studies: A Review
VSGL Lavanya
Indo-American Journal of Pharmaceutical sciences 11 (12), 74-80 , 2024
2024
Review on Buccal Drug Delivery System
VSAM Sri
Indo-American Journal of Pharmaceutical sciences 11 (12), 32-37 , 2024
2024
AA Review on pharmacological activities of Annona squamosa . Indo American Journal of Pharmaceutical Science
VSGBS Sai
Indo-American Journal of Pharmaceutical sciences 11 (12), 24-31 , 2024
2024
A Review based on Plant Derived Cardio Vascular Agents
VSA Srikanya
Indo-American Journal of Pharmaceutical sciences 11 (11), 532-540 , 2024
2024
Review On Floating Drug Delivery System by using Natural Polymers
VSK Kavitha
Indo-American Journal of Pharmaceutical sciences 11 (11), 478-486 , 2024
2024
Role of Fenugreek in Diabetes Treatment
VSKSH Chowdary
Indo-American Journal of Pharmaceutical sciences 11 (11), 470-477 , 2024
2024
Nanosponges:A Novel Class of Drug Delivery System-Review.
PDPS V Saikishore.M.Divya
Indo American Journal of Pharmaceutical Sciences 11 (6), 143-154 , 2024
2024
Design and Development of Core in-Cup tablet of Lansoprazole
MUR V.Saikishore
Indo-American Journal of Pharmaceutical sciences 11 (9), 281-288 , 2024
2024
Design and Development of Core in-Cup tablet of Lansoprazole
MD V.Saikishore
Indo-American Journal of Pharmaceutical sciences 11 (9), 273-280 , 2024
2024
Formulation and Evaluation of Floating tablets of Losartan potassium by using natural polymers
. V.Saikishore , P.Meghana
Indo-American Journal of Pharmaceutical sciences 11 (9), 265-272 , 2024
2024

MOST CITED SCHOLAR PUBLICATIONS

Extraction of chitin from chitosan from exoskeleton of shrimp for application in the pharmaceutical industry
YS Puvvada, S Vankayalapati, S Sukhavasi
International Current Pharmaceutical Journal 1 (9), 258-263 , 2012
2012
Citations: 313
Effect of casting solvent and polymer on permeability of propranolol hydrochloride through membrane controlled transdermal drug delivery system
TEGKM V. Sai Kishore
Indian Journal of Pharmaceutical Sciences 69 (5), 646-650 , 2007
2007
Citations: 61
Formulation and evaluation of fast dissolving tablets of amlodipine besylate by using Fenugreek seed mucilage and Ocimum basilicum gum
SS V. Sai Kishore
International Current Pharmaceutical Journal 1 (9), 243-249 , 2012
2012
Citations: 48
Formulation and Evaluation of Microspheres of Diltiazem Hydrochloride
MN V. Sai Kishore
Journal of Pharmaceutical Sciences 69 (4), 511-514 , 2007
2007
Citations: 46
Formulation and Evaluation of Transdermal Gels of Diltiazem Hydrochloride
TEGKM V. Sai Kishore
Indian Journal of Pharmaceutical Education and Research 42 (3), 272-276 , 2008
2008
Citations: 27
Formulation and Evaluation of Econazole Niosomes
MR V. Sai. Kishore, Y. Prem. Kumar, K.Vinod.Kumar, R. Raja Shekar
Scholars Academic Journal of Pharmacy 2 (4), 315-318 , 2013
2013
Citations: 26
Effect of Casting Solvent on Permeability of Antihypertensive Drugs through Ethyl Cellulose Films
VSKTEGK Murthy
Journal of Scientific & Industrial Research 67 (2), 147-150 , 2008
2008
Citations: 26
Design and development of chronopharmaceutical drug delivery of simvastatin
MS V. Sai Kishore
Journal of Chemical and Pharmaceutical Research 4 (6), 3195-3200 , 2012
2012
Citations: 25
Formulation and evaluation of fast dissolving tablets of amlodipine besylate by using hibiscus rosa – sinensis mucilage and modified gum karaya
SS V. Sai Kishore
International Journal of Pharmaceutical sciences and research 3 (10), 3975-3982 , 2012
2012
Citations: 13
Design and Development of Solid Dispersions of Simvastatin for Enhancing the Solubility
MS V. Sai Kishore
American Journal of PharmTech Research 2 (3), 733-740 , 2012
2012
Citations: 13
Design And Development Of Pulsincap For Chronopharmaceutical Drug Delivery Losartan Potassium
RLR V. Saikishore, B.Ramesh
Asian Journal of Pharmaceutical Research and Development 2 (3), 78-86 , 2014
2014
Citations: 12
Design and development of riluzole loaded chitosan nanoparticles by emulsification crosslinking
PYS V. Sai Kishore
International Journal of Pharmacy and Pharmaceutical sciences 4 (4), 244-248 , 2012
2012
Citations: 12
Plantago ovata seeds and Bhringaraj leaves as superdisintegrants: Formulation and evaluation of sotalol hydrochloride orodispersible tablets
DG V Sai Kishore, B.Tejaswara Rao,K.Pavani , D.Nagasen. K. Rakesh Varma
International journal of pharmaceutical, chemical and biological sciences 3 … , 2013
2013
Citations: 9
Formulation and evaluation of fast dissolving tablets of simvastatin using novel co-processed superdisintegrants
KVSPR V Sai Kishore, M. Teja Krishna
Scholars Academic Journal of Pharmacy 2 (4), 340-353 , 2013
2013
Citations: 8
Effect of casting solvent and polymer on permeability of propranolol hydrochloride through membrane-controlled transdermal drug delivery system
TEGK Murthy, V Saikishore
Asian Journal of Pharmaceutics (AJP) 2 (2) , 2008
2008
Citations: 8
Design and Development of Press Coated Prasugrel Hydrochloride Tablets for Pulsatile Drug Delivery System.
PSB V. Sai Kishore, N Narasimha Rao, GS Mahalakshmi Yadav
Research Journal of Pharmaceutical, Biological and Chemical Sciences 5 (1 … , 2014
2014
Citations: 7
Preparation and evaluation of floating microspheres of ritonavir.
LT V. Sai Kishore, S. Ershad, M. Sandeep, B. Sudheer , K. Adithya, U ...
International journal of research in pharmacy and chemistry 3 (4), 834-841 , 2013
2013
Citations: 7
Preparation and Evaluation of Chronopharmaceutical Drug Delivery of Lansoprazole.
DSP V. Sai Kishore, M. Sandeep, B. Sudheer , S. Ershad, K. Adithya
Research and Reviews: Journal of Pharmacy and Pharmaceutical Sciences 2 (4 … , 2013
2013
Citations: 7
Effect of casting solvent on permeability of antihypertensive drugs through Eudragit RS 100 films
TEGKM 4. V. Sai Kishore
Asian Journal of Pharmaceutics 1 (1), 108-114 , 2007
2007
Citations: 6
Formulation and evaluation of miconazole Nitrate loaded nanosponges for vaginal drug Delivery
JVR V.Saikishore, P. Suresh Kumar, N.Hematheerthani
Indo American Journal of Pharmaceutical Sciences 2 (6), 1028-1037 , 2015
2015
Citations: 5