G protein coupled receptor, nuclear receptor, biased agonism
847
Scholar Citations
12
Scholar h-index
14
Scholar i10-index
RECENT SCHOLAR PUBLICATIONS
Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria J Zhu, FY Qin, S Lei, R Gu, Q Qi, J Lu, KE Anderson, P Wipf, X Ma Nature Communications 15 (1), 10557 , 2024 2024 Citations: 5
Distinct roles of the extracellular surface residues of glucagon-like peptide-1 receptor in β-arrestin 1/2 signaling S Lei, Q Meng, Y Liu, Q Liu, A Dai, X Cai, MW Wang, Q Zhou, H Zhou, ... European Journal of Pharmacology 968, 176419 , 2024 2024 Citations: 5
Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors J Zhu, S Lei, J Lu, Y Hao, Q Qian, AS Devanathan, Z Feng, XQ Xie, P Wipf, ... European journal of medicinal chemistry 259, 115666 , 2023 2023 Citations: 12
Activation of PXR causes drug interactions with Paxlovid in transgenic mice S Lei, A Guo, J Lu, Q Qi, AS Devanathan, J Zhu, X Ma Acta Pharmaceutica Sinica B 13 (11), 4502-4510 , 2023 2023 Citations: 6
Identification of PXR activators from uncaria rhynchophylla (Gou Teng) and uncaria tomentosa (cat’s claw) S Lei, J Lu, A Cheng, Z Hussain, K Tidgewell, J Zhu, X Ma Drug Metabolism and Disposition 51 (5), 629-636 , 2023 2023 Citations: 5
Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) A Cheng, S Lei, J Zhu, J Lu, MF Paine, W Xie, X Ma Liver Research 6 (4), 251-257 , 2022 2022 Citations: 10
Iron metabolism mediates the relationship between Vitamin C and hepatic steatosis and fibrosis in NAFLD Z Hu, Y Li, B Ma, S Lei, X Wang Frontiers in Nutrition 9, 952056 , 2022 2022 Citations: 11
Precise druggability of the PTH type 1 receptor I Sutkeviciute, JY Lee, AD White, CS Maria, KA Peña, S Savransky, ... Nature chemical biology 18 (3), 272-280 , 2022 2022 Citations: 31
LncRNA MEG3 alleviates PFOS induced placental cell growth inhibition through its derived miR-770 targeting PTX3 J Li, X Quan, S Lei, G Chen, J Hong, Z Huang, Q Wang, W Song, X Yang Environmental Pollution 293, 118542 , 2022 2022 Citations: 20
PPARγ regulates triclosan induced placental dysfunction J Li, X Quan, Y Zhang, T Yu, S Lei, Z Huang, Q Wang, W Song, X Yang, ... Cells 11 (1), 86 , 2021 2021 Citations: 26
Role of CYP2A6 in methimazole bioactivation and hepatotoxicity J Li, Z Hussain, J Zhu, S Lei, J Lu, X Ma Chemical research in toxicology 34 (12), 2534-2539 , 2021 2021 Citations: 7
Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation AD White, KA Peña, LJ Clark, CS Maria, S Liu, FG Jean-Alphonse, JY Lee, ... Science signaling 14 (703), eabc5944 , 2021 2021 Citations: 93
PFOS Inhibited Normal Functional Development of Placenta Cells via PPARγ Signaling J Li, X Quan, S Lei, Z Huang, Q Wang, P Xu Biomedicines 9 (6), 677 , 2021 2021 Citations: 23
Clinical perspectives of isoniazid-induced liver injury S Lei, R Gu, X Ma Liver Research 5 (2), 45-52 , 2021 2021 Citations: 59
Precision druggability of a class B GPCR, the PTH type 1 receptor I Sutkeviciute, JY Lee, A White, P Doruker, K Pena, S Sanker, S Lei, ... The FASEB Journal 35 , 2021 2021
Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation LJ Clark, J Krieger, AD White, V Bondarenko, S Lei, F Fang, JY Lee, ... Nature chemical biology 16 (10), 1096-1104 , 2020 2020 Citations: 58
Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism S Lei, L Clydesdale, A Dai, X Cai, Y Feng, D Yang, YL Liang, C Koole, ... Journal of Biological Chemistry 293 (24), 9370-9387 , 2018 2018 Citations: 57
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex YL Liang, M Khoshouei, A Glukhova, SGB Furness, P Zhao, L Clydesdale, ... Nature 555 (7694), 121-125 , 2018 2018 Citations: 364
A historic study that opened a new chapter in nutritional science S Lei, D Yang, M Wang Acta Pharmacologica Sinica 37 (12), 1641-1644 , 2016 2016
G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells C Zhou, X Dai, Y Chen, Y Shen, S Lei, T Xiao, T Bartfai, J Ding, MW Wang Oncotarget 7 (11), 12823 , 2016 2016 Citations: 38
MOST CITED SCHOLAR PUBLICATIONS
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex YL Liang, M Khoshouei, A Glukhova, SGB Furness, P Zhao, L Clydesdale, ... Nature 555 (7694), 121-125 , 2018 2018 Citations: 364
Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation AD White, KA Peña, LJ Clark, CS Maria, S Liu, FG Jean-Alphonse, JY Lee, ... Science signaling 14 (703), eabc5944 , 2021 2021 Citations: 93
Clinical perspectives of isoniazid-induced liver injury S Lei, R Gu, X Ma Liver Research 5 (2), 45-52 , 2021 2021 Citations: 59
Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation LJ Clark, J Krieger, AD White, V Bondarenko, S Lei, F Fang, JY Lee, ... Nature chemical biology 16 (10), 1096-1104 , 2020 2020 Citations: 58
Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism S Lei, L Clydesdale, A Dai, X Cai, Y Feng, D Yang, YL Liang, C Koole, ... Journal of Biological Chemistry 293 (24), 9370-9387 , 2018 2018 Citations: 57
G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells C Zhou, X Dai, Y Chen, Y Shen, S Lei, T Xiao, T Bartfai, J Ding, MW Wang Oncotarget 7 (11), 12823 , 2016 2016 Citations: 38
Precise druggability of the PTH type 1 receptor I Sutkeviciute, JY Lee, AD White, CS Maria, KA Peña, S Savransky, ... Nature chemical biology 18 (3), 272-280 , 2022 2022 Citations: 31
PPARγ regulates triclosan induced placental dysfunction J Li, X Quan, Y Zhang, T Yu, S Lei, Z Huang, Q Wang, W Song, X Yang, ... Cells 11 (1), 86 , 2021 2021 Citations: 26
PFOS Inhibited Normal Functional Development of Placenta Cells via PPARγ Signaling J Li, X Quan, S Lei, Z Huang, Q Wang, P Xu Biomedicines 9 (6), 677 , 2021 2021 Citations: 23
LncRNA MEG3 alleviates PFOS induced placental cell growth inhibition through its derived miR-770 targeting PTX3 J Li, X Quan, S Lei, G Chen, J Hong, Z Huang, Q Wang, W Song, X Yang Environmental Pollution 293, 118542 , 2022 2022 Citations: 20
Application of chemical biology in target identification and drug discovery Y Zhu, T Xiao, S Lei, F Zhou, MW Wang Archives of pharmacal research 38 (9), 1642-1650 , 2015 2015 Citations: 17
Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors J Zhu, S Lei, J Lu, Y Hao, Q Qian, AS Devanathan, Z Feng, XQ Xie, P Wipf, ... European journal of medicinal chemistry 259, 115666 , 2023 2023 Citations: 12
Iron metabolism mediates the relationship between Vitamin C and hepatic steatosis and fibrosis in NAFLD Z Hu, Y Li, B Ma, S Lei, X Wang Frontiers in Nutrition 9, 952056 , 2022 2022 Citations: 11
Chemical basis of pregnane X receptor activators in the herbal supplement Gancao (licorice) A Cheng, S Lei, J Zhu, J Lu, MF Paine, W Xie, X Ma Liver Research 6 (4), 251-257 , 2022 2022 Citations: 10
Role of CYP2A6 in methimazole bioactivation and hepatotoxicity J Li, Z Hussain, J Zhu, S Lei, J Lu, X Ma Chemical research in toxicology 34 (12), 2534-2539 , 2021 2021 Citations: 7
Activation of PXR causes drug interactions with Paxlovid in transgenic mice S Lei, A Guo, J Lu, Q Qi, AS Devanathan, J Zhu, X Ma Acta Pharmaceutica Sinica B 13 (11), 4502-4510 , 2023 2023 Citations: 6
Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria J Zhu, FY Qin, S Lei, R Gu, Q Qi, J Lu, KE Anderson, P Wipf, X Ma Nature Communications 15 (1), 10557 , 2024 2024 Citations: 5
Distinct roles of the extracellular surface residues of glucagon-like peptide-1 receptor in β-arrestin 1/2 signaling S Lei, Q Meng, Y Liu, Q Liu, A Dai, X Cai, MW Wang, Q Zhou, H Zhou, ... European Journal of Pharmacology 968, 176419 , 2024 2024 Citations: 5
Identification of PXR activators from uncaria rhynchophylla (Gou Teng) and uncaria tomentosa (cat’s claw) S Lei, J Lu, A Cheng, Z Hussain, K Tidgewell, J Zhu, X Ma Drug Metabolism and Disposition 51 (5), 629-636 , 2023 2023 Citations: 5
Precision druggability of a class B GPCR, the PTH type 1 receptor I Sutkeviciute, JY Lee, A White, P Doruker, K Pena, S Sanker, S Lei, ... The FASEB Journal 35 , 2021 2021
