As a Professor and PG Head of the Department of Pharmaceutics at Ashokrao Mane College of Pharmacy, Peth-Vadgaon, I have over a decade of experience in teaching, research, and publication in the field of pharmacy. I hold a PhD in Pharmaceutical Sciences from Shri JJT University and a M Pharmacy in Pharmaceutical Technology from Bharati Vidyapeeth College of Pharmacy Kolhapur.
My research interests include ionic complexation, nano-structured lipid carrier gel, and biogenic chalcones. I have published multiple research papers in international journals, such as the Journal of Biomolecular Structure and Dynamics and the International Research Journal of Pharmacy. I have also received several honors and awards for my research paper presentations at national and state level symposia and competitions. My mission is to advance the knowledge and practice of pharmaceutics through innovative education and research.
EDUCATION
M. Pharm. Ph.D. Post Doctoral Fellow
RESEARCH, TEACHING, or OTHER INTERESTS
General Pharmacology, Toxicology and Pharmaceutics, Pharmacy, Pharmaceutical Science, Drug Discovery
Advancements in Cubosomes: A Promising Platform for Targeted Anticancer Drug Delivery Harshavardhan D Patil, Durgacharan A Bhagwat, Sachin S Mali, Suprit D Saoji, Dipali A Nawadkar, Sonali A Chikhalwale, Vijay R Chidrawar, Pooja V Nagime, Chuda Chitasupho, Sudarshan Singh Indonesian Journal of Pharmacy, 2026 Nanosized particles are stabilised by polymers and made mostly of amphiphilic lipids known as cubosomes (CUBs). Encapsulating hydrophilic, hydrophobic, and amphiphilic pharmaceuticals is made effective by their internal bi-continuous cubic phase architecture, which gives a high surface area and partitioned aqueous domains. These self-assembled nanoparticles exhibit thermodynamic stability, biocompatibility, and mucoadhesive properties, making them ideal carriers for diverse multiple administration routes, including oral, transdermal, parenteral, and ocular. Problems with medication solubility, bioavailability, and non-specific toxicity are some of the most important ones that CUBs aim to solve. This review presents a comprehensive overview of CUB structure, types, formulation methods, and characterization techniques. The review emphasizes recent advancements in CUB-based delivery of chemotherapeutic agents, including paclitaxel and doxorubicin, cisplatin, methotrexate, and 5-fluorouracil, highlighting their improved pharmacokinetics and reduced systemic toxicity Despite manufacturing challenges, ongoing research into scalable production and novel excipients continues to support their translational promise. CUBs represent a versatile and potent platform in nanomedicine, offering substantial improvements in drug delivery and cancer treatment. Recent advancements in formulation strategies and surface modification is further strengthened their therapeutic potential. Cubosomes as a promising platform in precision oncology and next generation cancer therapeutics.
Unrevealing the potential of fibrous biomaterials in cartilage tissue engineering: a review Sachin S. Mali, Dipak S. Thorat, Anil Kumar Singh, Prajakta R. Patil, Snehal S. Patil, Akshay Kundale, Yogesh V. Ushir, Durgacharan A. Bhagwat, Sheeba Shafi, Sudarshan Singh Zeitschrift Fur Naturforschung Section C Journal of Biosciences, 2026 Fibrous biomaterials have showed considerable potential in cartilage tissue engineering due to their ability to imitate the structure and characteristics of the original extracellular matrix. Sustainable biomaterials such as chitosan, silk fibroin, and collagen can be produced into a variety of shapes, including hydrogels, scaffolds, and electrospun nanofibers, to develop an optimal milieu for chondrocyte adhesion, proliferation, and cartilage matrix deposition. In recent years, various studies showed that biomaterials-based fiber mats obtained through electrospinning as scaffolds exhibit remarkable chondrocyte growth support. These fiber mats promote high chondrocyte viability and cell proliferation, particularly when thin neutralized fibers are utilized. The biomimetic attributes of these biomaterials obtained from renewable resources such as plants, animals, and microbes have intrinsic benefits such as biocompatibility, microstructure resemblance to the original extracellular matrix, and adjustable mechanical properties. However, there are still hurdles in optimizing scaffold–cell interactions, controlled degradation, stress response, and flexibility for successful clinical translation. As a result, fibrous biomaterials exhibit significant potential for cartilage tissue engineering by promoting chondrocyte adhesion, proliferation, and cartilage matrix deposition. Nonetheless, additional study is required to solve the obstacles and optimize these materials for successful clinical applications.
Balancing Innovation and Patient Safety: Ethical AI Deployment in Healthcare Responsible AI Principles and Practices, 2026
Sustainability in AI Development Responsible AI Principles and Practices, 2026
Green Synthesis of Copper Nanoparticles from Pineapple Peel Dietary Fibers: Antibacterial, Antifungal, Antioxidant, and Antidiabetic Activities Sopan Namdev Nangare, Pallavi Vijay More, Sachin Suryakant Mali, Swapnil Vishwambhar Thakare, Dilip Ashok Patil, Chetan Jayvant Bhavsar Journal of Macromolecular Science Part B Physics, 2026 Dietary fiber-based approaches have recently gained notable attention in biomedical applications due to their biocompatibility, biodegradability, and eco-friendliness. Ripe Ananas comosus (pineapple) peel, typically discarded as waste, is a rich source of soluble dietary fiber, cellulose, and hemicellulose. In the present study, a green method was employed for first-time synthesis of copper nanoparticles (Cu-Nano) using dietary fiber extract derived from A. comosus peel powder. UV-Visible analysis and ATR-FTIR spectroscopy confirmed the reduction of copper ions and successful synthesis of Cu-Nano. The nanoparticles exhibited hydrodynamic diameter of 253.6 nm, confirming their nanosized dimensions, and showed zeta potential of −17.34 mV, indicating good colloidal stability. Furthermore, HR-TEM analysis revealed uniformly dispersed spherical particles with average diameter of 6.57 ± 1.50 nm, while XRD analysis confirmed their crystalline nature. The Cu-Nano exhibited significant antibacterial activity against Staphylococcus aureus and Escherichia coli, as well as antifungal activity against Aspergillus niger and Fusarium moniliforme. Additionally, Cu-Nano demonstrated strong antioxidant activity (IC50: 88.27 ppm) and effective inhibition of α-amylase (IC50: 420.32 ppm), indicating promising antidiabetic potential. In conclusion, green-synthesized Cu-Nano utilizing dietary fibers from pineapple peel waste represents promising multifunctional therapeutic platform with potent antimicrobial, antioxidant, and antidiabetic effects, holding significant potential for future biomedical applications.
Polysaccharide-based oral delivery systems for probiotics Adrija Mukherjee, Sachin S. Mali, Prajakta R. Patil, Sudarshan Singh, Ruma Sarkar Advances in Probiotic Delivery Systems Strategies for Enhanced Viability Targeted Delivery and Efficacy, 2025
Development of floating microspheres of anti-ulcer drug as a gastroretentive drug delivery system Der Pharmacia Lettre, 2015
Project writing for retail pharmacy practical training: A proforma Research Journal of Pharmacy and Technology, 2014
Extraction and characterization of mucilage from Lepidium sativum Linn. Seeds Der Pharmacia Lettre, 2014
Narrative review: A rational approach to needle free Insulin Technology Research Journal of Pharmacy and Technology, 2014
RECENT SCHOLAR PUBLICATIONS
Sustainability in AI Development RR Patil, SA Bandgar, SS Mali, PR Patil, DR Davare Responsible AI: Principles and Practices, 143-174 , 2026 2026
Balancing Innovation and Patient Safety: Ethical AI Deployment in Healthcare PR Patil, SS Mali, RR Patil, DR Davare Responsible AI: Principles and Practices, 29-68 , 2026 2026
Unrevealing the potential of fibrous biomaterials in cartilage tissue engineering: a review SS Mali, DS Thorat, AK Singh, PR Patil, SS Patil, A Kundale, YV Ushir, ... Zeitschrift für Naturforschung C 81 (3-4), 217-242 , 2026 2026
Digital Health Platforms in Pharmacy: Transforming Patient Engagement and Care. A Bandyopadhyay, T Pal, S Mali, S Singh, DA Bhagwat, PV Nagime Current Pharmaceutical Design , 2026 2026
Analytical prospects of molybdenum oxide quantum dots: Emerging fluorescent platforms for food safety assessment RS Dhole, NB Patil, SN Nangare, MR Mahajan, VR Singamaneni, ... Microchemical Journal, 117805 , 2026 2026
Mechanistic investigation of the Anti-arthritic Potential of Impatiens Balsamina: Phytochemical Profiling, Pharmacological Assessment, and In Silico Molecular Docking PS Gavarkar, RS Chavan, R Adnaik, SS Mali, S Singh Journal of Molecular Structure, 145938 , 2026 2026
Pharmacokinetic Profiling and in Vivo Anticancer Evaluation of Abiraterone Acetate Loaded Nanostructured Lipid Carriers SN Nagoba, AB Swami, AN Deshpande, AS Jalindar, SS Mali, S Singh BioNanoScience 16 (3), 206 , 2026 2026
Comment on" Exogenous dendritic cell-derived exosomes promote Treg differentiation via IDO1-Kyn-AhR axis and improve cardiac function after myocardial infarction". R Adnaik, P Adnaik, SS Mali International Immunopharmacology 175, 116382-116382 , 2026 2026
Green Synthesis of Copper Nanoparticles from Pineapple Peel Dietary Fibers: Antibacterial, Antifungal, Antioxidant, and Antidiabetic Activities SN Nangare, PV More, SS Mali, SV Thakare, DA Patil, CJ Bhavsar Journal of Macromolecular Science, Part B, 1-21 , 2026 2026
Plant-mediated Synthesis of Zinc Oxide Nanoparticles Derived from Holarrhena antidysenterica Bark Extract for Antimicrobial Drug Delivery S Patil, PS Pawde, YD Dange, RS Adnaik, SS Mali, PB Varne Drug Delivery 16 (42s), 877-886 , 2026 2026
Stimuli-Responsive Nanocarriers for Targeted Drug Delivery: A Review. KSV Thorat VH, Pathan SJ, Patil PB, Toraskar PB, Mali SS* Int J Drug Deliv Technol. 16 (2026;16(24s)), 233-247 , 2026 2026
Advancements in Cubosomes: A Promising Platform for Targeted Anticancer Drug Delivery HD Patil, DA Bhagwat, SS Mali, SD Saoji, DA Nawadkar, SA Chikhalwale, ... Indonesian Journal of Pharmacy, 238-256 , 2026 2026
Rutin-Loaded Nanostructured Lipid Carriers incorporated Hydrogel for the Management Psoriasis: In Vitro and In Vivo Assessment PB Pujari, AJ Shinde, AC Shedmake, AS Jalindar, SS Mali, S Singh BioNanoScience 16 (1), 74 , 2026 2026 Citations: 1
Demystifying the potential pharmaceutical attributes of corn silk: an agriculture bio-waste SS Mali, DS Thorat, S Singh, YV Ushir, PR Patil, DR Davare, PV Nagime, ... Food and Humanity 5, 100686 , 2025 2025 Citations: 2
Smart solutions for tough infections: The rise of next-gen transdermal drug delivery SS Mali, PD Jadhav, SJ Nadaf Current Opinion in Pharmacology 84 , 2025 2025
Quality by design approach for nifedipine-adsorbed fluorite-loaded calcium-low methoxy pectin beads to impart chronotherapy: in vitro and in vivo assessment RS Jagtap, SK Mohite, SR Jagtap, SJ Nadaf, SS Mali, PS Sankpal, ... Naunyn-Schmiedeberg's Archives of Pharmacology, 1-12 , 2025 2025
Recent Advances in Synthetic Approaches for 1, 3, 4-Oxadiazole Derivatives: A Comprehensive Review on Therapeutic Applications T Khamkar, R Kadam, SS Mali, B Udugade, S Singh The Open Medicinal Chemistry Journal 19 (1) , 2025 2025 Citations: 10
Smart healthcare: Artificial intelligences impact on drug development and patient care S Mendhi, K Sawarkar, A Shete, K Vinchurkar, SS Mali, S Singh, ... Intelligent Pharmacy 3 (3), 225-234 , 2025 2025 Citations: 10
Development of mesalamine loaded-fenugreek gum decorated pectin microspheres for colonic drug delivery: Ex-vivo and in-vitro characterizations PP Khamkar, KS Wagh, SN Nangare, SS Mali, GS Patil Annales Pharmaceutiques Françaises 83 (3), 514-528 , 2025 2025 Citations: 6
Design and synthesis of surface-decorated zinc-doped carbon quantum dots as fluorescent probes for tartrazine detection in real food samples exploiting the inner filter effect … SS Chaudhari, PO Patil, SS Mali, MS Alam, SN Nangare, SB Bari, ... Food Control 168, 110925 , 2025 2025 Citations: 14
MOST CITED SCHOLAR PUBLICATIONS
STERILE PARENTERAL PRODUCTS: A NARRATIVE APPROACH SD Dongare, SS Mali, PV Patrekar Journal of Drug Delivery and Therapeutics 5 (1), 41-48 , 2015 2015.0 Citations: 67
Phytochemical screening and In Vitro Antioxidant potential of Memecylon umbellatum Burm leaf extracts SG Killedar, SS Mali, HN More, SJ Nadaf, SS Salunkhe, RS Karade Journal of Drug Delivery and Therapeutics 4 (2) , 2014 2014.0 Citations: 37
Pelletization Technology: Methods and Applications-A Review AA Ahir, SS Mali, AA Hajare, DA Bhagwat, PV Patrekar Research Journal of Pharmacy and Technology 8 (2), 131-138 , 2015 2015.0 Citations: 36
Review on: high-throughput screening is an approach to drug discovery AA Hajare, SS Salunkhe, SS Mali, SS Gorde, SJ Nadaf, SA Pishawikar Am. J. PharmTech. Res 4, 112-129 , 2013 2013.0 Citations: 34
Ethosomes as novel drug delivery system: A review PV Patrekar, SJ Inamdar, SS Mali, MT Mujib, AA Ahir, AH Hosmani The Pharma Innovation 4 (9, Part A), 10 , 2015 2015.0 Citations: 32
Extraction and characterization of mucilage from Lepidium sativum Linn. seeds NM Bhatia, SS Salunkhe, SS Mali, SS Gadkari, AA Hajare, SV Gaikwad, ... Citations: 24
Identification of potential biogenic chalcones against antibiotic resistant efflux pump (AcrB) via computational study S Rathod, S Dey, S Pawar, R Dhavale, P Choudhari, E Rajakumara, ... Journal of Biomolecular Structure and Dynamics 42 (10), 5178-5196 , 2024 2024.0 Citations: 23
A review on development of biorelevant dissolution medium B Bhagat Nitin, V Yadav Adhikrao, S Mali Sachin, A Khutale Rohan, ... Journal of Drug Delivery & Therapeutics 4 (2), 140-148 , 2014 2014.0 Citations: 22
Formulation and evaluation of ciprofloxacin suspension using natural suspending agent SJ Nadaf, SS Mali, SS Salunkhe, PM Kamble International Journal of Pharma Sciences and Research 5 (03), 63-70 , 2014 2014.0 Citations: 22
Lipid nanoparticles: Amodern Formulation Approach in Topical drug Delivery Systems AA Hajare, SS Mali, AA Ahir, JD Thorat, SS Salunkhe, SJ Nadaf, ... Journal of Advanced Drug Delivery 1 (1), 30-37 , 2014 2014.0 Citations: 22
Synthesis & Evaluation of isoxazole for their antimicrobial activity S Pol, V Kadam, B Ramesh, SS Mali, V Patil Citations: 18
Nanorobots: novel emerging technology in the development of pharmaceuticals for drug delivery applications SS Salunkhe, NM Bhatia, SS Mali, JD Thorat, AA Ahir, AA Hajare J Pharm Pharm Sci 6, 4728-4744 , 2014 2014.0 Citations: 16
Design and synthesis of surface-decorated zinc-doped carbon quantum dots as fluorescent probes for tartrazine detection in real food samples exploiting the inner filter effect … SS Chaudhari, PO Patil, SS Mali, MS Alam, SN Nangare, SB Bari, ... Food Control 168, 110925 , 2025 2025.0 Citations: 14
A Rational Approach to Ocular Drug Delivery System: An Overview A Hajare, S Mali, S Salunke, S Nadaf, N Bhatia, P Bagal, S Gaikwad, ... World Journal of Pharmaceutical Science 3 (2), 3324-3348 , 2014 2014.0 Citations: 14
Formulation and in vitro evaluation of gel for SPF determination and free radical scavenging activity of turpentine and lavender oil SS Mali, SG Killedar Pharma Innov. J 7 (3), 85-90 , 2018 2018.0 Citations: 12
Comparative efficiency of formulation techniques for development of salbutamol sulphate loaded liposomes SM Honmane, SS Salunkhe, AA Hajare, NM Bhatia, SS Mali International research journal of pharmacy 5 (2), 70-74 , 2014 2014.0 Citations: 12
Proniosomes: Modern drug delivery system SS Suryawanshi, PP Patil, RG Gaikwad, SS Mali, SL Pol Pharmaceutical resonance, 41-56 , 2021 2021.0 Citations: 11
Recent Advances in Synthetic Approaches for 1, 3, 4-Oxadiazole Derivatives: A Comprehensive Review on Therapeutic Applications T Khamkar, R Kadam, SS Mali, B Udugade, S Singh The Open Medicinal Chemistry Journal 19 (1) , 2025 2025.0 Citations: 10
Smart healthcare: Artificial intelligences impact on drug development and patient care S Mendhi, K Sawarkar, A Shete, K Vinchurkar, SS Mali, S Singh, ... Intelligent Pharmacy 3 (3), 225-234 , 2025 2025.0 Citations: 10
Development of mesalamine loaded-fenugreek gum decorated pectin microspheres for colonic drug delivery: Ex-vivo and in-vitro characterizations PP Khamkar, KS Wagh, SN Nangare, SS Mali, GS Patil Annales Pharmaceutiques Françaises 83 (3), 514-528 , 2025 2025.0 Citations: 6
RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)
1. Patent Filled: Novel ketoconazole loaded NLC gel for management of skin diseases. Date: 28-06-2023, patent number 202321043227 for an INDIAN Patent.
2. Patent Filled: The formulation of transdermal patch of diclofenac sodium (202221053905 a/2022) Date: 30/09/2022 for an INDIAN Patent.
3. Patent Filled: The composition of polyherbal soap for skin (202221051622 a/2022) Date: 07/10/2022 for an INDIAN Patent.
4. Patent Filled: Formulation of nifedipine using natural polymer for buccal mucoadhesive drug delivery (202321029708) for an INDIAN Patent. Publication Number: 26/2023, Publication Date: 30/06/2023
5. Design Patent Filled: Apparatus for preparation of nanolipoidal systems for the management of skin cancer. Patent Application Number: (433206-001) for an INDIAN Patent.
6. Granted: Smart medicine dispenser with multiple tablet organizer. Serial No. : 150748, Design No. : 388664-001, Date: 19/06/2023, Date of Issue : 22/12/2023. Registration for an INDIAN Patent Design, 2023.
7. Granted: X-ray firm viewer. Design No. 380133-001, Date: 25/02/2023, No : 135735, Date of Issue : 16/05/2023, Registration for a INDIAN Patent Design, 2023
8. Granted: Antimicrobial bandage dispensing Machine, Design number: 6361558, Grant date: 30 April 2024, Registration date: 24 April 2024, Registration for a UK Design: 2024
9. Granted: SINGLE COLUMN - DRY COLUMN VACUUM CHROMATOGRAPHY APPARATUS, Design application number:410791-001. Serial No