Ph.D from Sri Padmavati Mahila Visvavidyalayam;
M.Pharm Pharmacology from Annamalai University;
B.Pharm from Acharya Nagarjuna University
EDUCATION
M.Pharm, Ph.D.
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmacology, Toxicology and Pharmaceutics, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, Pharmaceutical Science
32
Scopus Publications
114
Scholar Citations
6
Scholar h-index
2
Scholar i10-index
Scopus Publications
Comparative analysis of Mpox clades: epidemiology, transmission dynamics, and detection strategies Shriyansh Srivastava, Dheeraj Sharma, Sathvik Belagodu Sridhar, Sachin Kumar, G. S. N. Koteswara Rao, Roja Rani Budha, Molakpogu Ravindra Babu, Rakesh Sahu, Sanjit Sah, Rachana Mehta, Nahun Alejandro Giraldo-Corrales, Jack Feehan, Vasso Apostolopoulos, Alfonso J. Rodriguez-Morales BMC Infectious Diseases, 2025 BACKGROUND: Monkeypox (Mpox), a zoonotic disease caused by the monkeypox virus, has gained global attention due to rising incidence and the emergence of new clades. Understanding the epidemiology, transmission dynamics, and diagnostic challenges associated with the two major clades, Clades I and II, is crucial for outbreak preparedness and control. METHODS: This review analyzes Mpox clades, highlighting their geographic distribution, virulence, transmissibility, and diagnostic approaches. It also presents recent outbreaks, diagnostic advancements, vaccination strategies, and critical research gaps in Mpox surveillance and response. RESULTS: Clade I, primarily in Central Africa, exhibits the highest virulence with a 5–10% case fatality rate. Clade II, which includes subclades IIa, IIb, and the newly identified Clade Ib, demonstrates lower virulence but higher transmissibility beyond endemic regions. Recent outbreaks (2022–2024), driven by Clade IIb, present atypical clinical presentations and emphasize intimate human-to-human contact as a key transmission route. Polymerase chain reaction, next-generation sequencing, and emerging CRISPR-based diagnostics have improved detection, while modified vaccinia Ankara-based vaccines have shown effectiveness despite challenges in equitable distribution. CONCLUSIONS: Addressing critical research gaps, such as clade-specific virulence mechanisms, zoonotic reservoirs, and evolutionary patterns, is essential for improving Mpox surveillance and control. Strengthening genomic surveillance, expanding access to affordable diagnostics, and fostering international collaboration will enhance preparedness for future outbreaks and mitigate the impact of this emerging infectious disease. HIGHLIGHTS: • Comparison of Mpox virus (MPXV) clades, in geography, virulence, transmission, and clinical outcomes between Clade I, Clade II, and emerging subclades IIb and Ib. • The epidemiology of Mpox focuses on the 2022–2024 global outbreaks of Clade IIb, marked by unusual clinical presentations and fast human-to-human spread in non-endemic areas. • Key advancements in diagnostic technologies like PCR, NGS, and CRISPR assays, improving MPXV detection and clade differentiation. • The effectiveness of MVA-based vaccines against various MPXV clades is presented while highlighting challenges in equitable distribution and region-specific vaccination strategies. • Emerging Mpox research priorities include genomic surveillance, clade-specific virulence, affordable diagnostics, and overcoming socioeconomic barriers to outbreak management.
Genistein and Gastrointestinal Cancers: A Comprehensive Review of Recent Studies and Future Outlook Rohit Yennawar, Nosheen Abjani, Neel Parekh, Roja Rani Budha, Ginpreet Kaur, Hemant Joshi, Seema Ramniwas, Harvinder Popli, Shafiul Haque, Darin Mansor Mathkor, Hardeep Singh Tuli Journal of Biochemical and Molecular Toxicology, 2025 Cancer is a global disease that causes millions of deaths annually, with gastrointestinal cancers becoming more prevalent than lung and breast cancers. Lifestyle factors like smoking and unhealthy eating habits increase the risk of cancer. Precision medicine approaches are needed to improve patient outcomes and cancer survival rates. Genistein, a natural isoflavonoid, acts as an anticancer medication by inducing apoptosis, preventing metastasis, and triggering cell death. It relies on various signaling pathways, including JAK1/2‐STAT3, AKT/MDM2, EGFR, MEK/ERK, Shh‐Gli1, MMP‐2, FLT4, STAT3, PLK‐1, and others. Elevated serum concentrations of isoflavones like genistein and daidzein have been linked to a decreased incidence of stomach cancer. Consumption of genistein through diet has been linked to potential health benefits, such as heart disease prevention, gastrointestinal, prostate, and breast cancer prevention through chemotherapy, and alleviation of postmenopausal symptoms. Genistein is a potent anticancer medication that works against various cancer types. This review examines the pharmacokinetics, chemistry, and possible applications of genistein in the treatment of pancreatic, esophageal, gastric, liver, and colorectal malignancies. The utilization of nanotechnology in conjunction with genistein is also discussed.
Bionanocomposites in Nasal Drug Delivery RajaSekhar Reddy Alavala, S. N. Koteswara Rao Gudhanti, Sree Harsha Nagaraja, Diya Karbhari, Roja Rani Budha, Khushwant S. Yadav Bionanocomposites for Biomedical Applications Fundamental Concepts Impacts and Clinical Applications, 2025 Bionanocomposites have recently gained attention because of their enhanced physicochemical characteristics, which are more beneficial in the biomedical sector. When drugs are delivered using targeted nanocomposites, the negative effects of highly specific drugs are avoided, and a controlled release rate is ensured at the intended site. Combining two or more components to create a single material with special qualities, including high loading capacity, increased mechanical capabilities, reduced toxicity, improved biocompatibility and biodegradability, and the ability to image guidance are the special characteristics of the bionanocomposites. The current book chapter deals with the different synthetic approaches of nanocomposites by using biopolymers from various sources. The major focus of the applications of the nanocomposites was given to nasal drug delivery for treating various diseases with suitable examples. There was in-depth information, and analysis was provided to understand the nasal route as the drug delivery site for various categories of drugs. The current research and its contribution to promoting the use of nanocomposites as nasal drug delivery systems were discussed in detail.
Metallic Biomaterials for Pharmaceutical and Biomedical Applications Metals in Medicine Volume 1 Metals for Tissue Engineering and Pharmaceutical Applications, 2025
Utilization of Palladium in Photothermal Therapy of Cancer Metals in Medicine Volume 2 Metallic Nanoparticles for Biomedical Applications, 2025
Metallic Foams for Biomedical Application Metals in Medicine Volume 1 Metals for Tissue Engineering and Pharmaceutical Applications, 2025
Diagnostic and Surgical Uses of Explainable AI (XAI) Roja Rani Budha, Saba Wahid A.M. Khan, Tushar Lokhande, G.S.N. Koteswara Rao, Shams Aaghaz Explainable and Responsible Artificial Intelligence in Healthcare, 2025
Computational Modelling for Formulation Design Teja Kumar Ponduri, Roja Rani Budha, Deepika Paliwal, Kartheek Siripurapu, Rajasekhar Reddy Alavala, S. N. Koteswara Rao G. Applications of Computational Tools in Drug Design and Development, 2025
Targeting H3N2 influenza: advancements in treatment and vaccine strategies Shriyansh Srivastava, Nandani Jayaswal, Sachin Kumar, G. S. N. Koteswara Rao, Roja Rani Budha, Aroop Mohanty, Rachana Mehta, Vasso Apostolopoulos, Sanjit Sah, D. Katterine Bonilla-Aldana, Ricardo Ulloque-Badaracco, Alfonso J. Rodriguez-Morales Expert Review of Anti Infective Therapy, 2025
Quantum dots in diagnostic imaging GSN Koteswara Rao, Rajasekhar Reddy Alavala, Praveen Sivadasu, Roja Rani Budha, Khushwant S. Yadav Green Sustainable Process for Chemical and Environmental Engineering and Science Recent Advances in Nanocarriers, 2023
Bionanocomposites in Nasal Drug Delivery RSR Alavala, SNKR Gudhanti, SH Nagaraja, D Karbhari, RR Budha, ... Bionanocomposites for Biomedical Applications, 176-199 , 2026 2026 Citations: 1
Comparative analysis of Mpox clades: epidemiology, transmission dynamics, and detection strategies S Srivastava, D Sharma, SB Sridhar, S Kumar, GSNK Rao, RR Budha, ... BMC infectious diseases 25 (1), 1290 , 2025 2025 Citations: 11
Modern Computational Intelligence Based Drug Repurposing for Cancer RR Budha, N Khan, SWAM Khan, ES Attar, SNK Rao G Applications of Computational Tools in Drug Design and Development, 859-884 , 2025 2025
Advances in the Computational Prediction of Absorption Prediction of Pharmaceuticals SWAM Khan, A Pandey, S Mishra, RR Budha, SNKR G Applications of Computational Tools in Drug Design and Development, 387-425 , 2025 2025 Citations: 1
Computational modelling of pharmaceutical die filling processes NB Shaik, RR Budha, BR Jena, RR Alavala, SNK Rao G Applications of computational tools in drug design and development, 199-243 , 2025 2025 Citations: 1
Protein Binding Prediction by Computational Methods R Mondal, D Paliwal, A Thakur, R Sahu, RR Budha Applications of Computational Tools in Drug Design and Development, 427-473 , 2025 2025 Citations: 2
Computational Modelling for Formulation Design TK Ponduri, RR Budha, D Paliwal, K Siripurapu, RR Alavala, SNK Rao G Applications of Computational Tools in Drug Design and Development, 55-98 , 2025 2025 Citations: 4
Inhalation Aerosol Based Targeted Drug Delivery to Upper Airways: Computational Fluid Dynamics (CFD) Approach BR Jena, S Tripathy, SK Swain, RR Budha, NB Shaik, RR Alavala, ... Applications of Computational Tools in Drug Design and Development, 245-277 , 2025 2025 Citations: 1
Revolutionizing Cancer Treatment: Harnessing Cell-membrane Coated Nanoparticles for Precise Targeting and Therapy P Waghode, GSNK Rao, S Deshpande, RR Budha, RR Alavala, ... Current Cancer Therapy Reviews 21 (3), 373-389 , 2025 2025 Citations: 1
Rising burden of human metapneumovirus: A call for global preparedness S Srivastava, D Sharma, SB Sridhar, S Kumar, GSNK Rao, RR Budha, ... Clinical Infection in Practice 26, 100416 , 2025 2025
Diagnostic and Surgical Uses of Explainable AI (XAI) RR Budha, SWAM Khan, T Lokhande, GSNK Rao, S Aaghaz Explainable and Responsible Artificial Intelligence in Healthcare, 65-88 , 2025 2025 Citations: 2
Autonomous Robots: A Disruptive Technology in the Health Sector BR Jena, GSNK Rao, NJ Kothakota, RR Budha, L Srinivas, J Rajkumar, ... Creating Smart Healthcare with Blockchain and Advanced Digital Technology … , 2025 2025 Citations: 4
Metallic Foams for Biomedical Application D Yadav, GSNK Rao, RR Budha, NB Rekha Metals in Medicine, 85-100 , 2025 2025 Citations: 1
Utilization of Palladium in Photothermal Therapy of Cancer SK Konidala, BS Padya, GSNK Rao, RR Budha Metals in Medicine, 371-392 , 2025 2025
Metallic Biomaterials for Pharmaceutical and Biomedical Applications S Chaudhary, RR Budha, GSNK Rao, SK Konidala Metals in Medicine, 41-57 , 2025 2025 Citations: 1
Exploration of green catalytic Hantzsch process for synthesis of polyhydroquinoline derivatives and their in silico & in vitro evaluation as anti-tubercular agents TS Savale, N Joshi, SM Mathure, SS Chobe, RA More, RR Budha, ... Journal of Molecular Structure 1320, 139703 , 2025 2025 Citations: 7
Targeting H3N2 influenza: Advancements in treatment and vaccine strategies S Srivastava, N Jayaswal, S Kumar, GSNK Rao, RR Budha, A Mohanty, ... Expert Review of Anti-infective Therapy 23 (1), 5-18 , 2025 2025 Citations: 9
Targeting Mpox: From Pharmacological Mechanisms to Next-Generation Therapies S Srivastava, R Sharma, SB Sridhar, A Mohammed, M Tariq, F Abdulhafiz, ... Preprints, 2025071265 , 2025 2025 Citations: 1
Pediatric Diffuse High-Grade Gliomas: A Comprehensive Review Of Advanced Methods Of Diagnosis And Treatment RR Budha, SWAM Khan, DC Sharma, Y Kulchandani, KR Gsn Current Cancer Drug Targets , 2025 2025 Citations: 2
Functional polymeric coatings for immediate release dosage forms PA Naidu, GSNK Rao, RR Alavala, RR Budha, P Kumar, KS Yadav Polymers for Oral Drug Delivery Technologies, 523-540 , 2025 2025
MOST CITED SCHOLAR PUBLICATIONS
Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization HM Aldawsari, NR Naveen, NA Alhakamy, PS Goudanavar, GSNK Rao, ... Drug Delivery 29 (1), 2258-2268 , 2022 2022 Citations: 28
Comparative analysis of Mpox clades: epidemiology, transmission dynamics, and detection strategies S Srivastava, D Sharma, SB Sridhar, S Kumar, GSNK Rao, RR Budha, ... BMC infectious diseases 25 (1), 1290 , 2025 2025 Citations: 11
Targeting H3N2 influenza: Advancements in treatment and vaccine strategies S Srivastava, N Jayaswal, S Kumar, GSNK Rao, RR Budha, A Mohanty, ... Expert Review of Anti-infective Therapy 23 (1), 5-18 , 2025 2025 Citations: 9
Exploration of green catalytic Hantzsch process for synthesis of polyhydroquinoline derivatives and their in silico & in vitro evaluation as anti-tubercular agents TS Savale, N Joshi, SM Mathure, SS Chobe, RA More, RR Budha, ... Journal of Molecular Structure 1320, 139703 , 2025 2025 Citations: 7
Development, characterization and optimization of solid lipid nanoparticles of alpha-mangostin by central composite design approach VN Babu, GSNK Rao, RR Budha, RR Alavala, PK Desu, GK Babu, ... Journal of Applied Pharmaceutical Science 13 (8), 140-150 , 2023 2023 Citations: 7
Radiopharmaceuticals: A new vista for diagnosis and treatment of thyroid cancer S Vernekar, RR Budha, RR Alavala Current Radiopharmaceuticals 17 (2), 148-162 , 2024 2024 Citations: 6
Computational Modelling for Formulation Design TK Ponduri, RR Budha, D Paliwal, K Siripurapu, RR Alavala, SNK Rao G Applications of Computational Tools in Drug Design and Development, 55-98 , 2025 2025 Citations: 4
Autonomous Robots: A Disruptive Technology in the Health Sector BR Jena, GSNK Rao, NJ Kothakota, RR Budha, L Srinivas, J Rajkumar, ... Creating Smart Healthcare with Blockchain and Advanced Digital Technology … , 2025 2025 Citations: 4
Additives screening for the formulation of solid lipid nanoparticles of alpha-mangostin NB Vutti, SKR Gudhanti, RR Alavala, PK Desu, RR Budha, KB Govada, ... Journal of Research in Pharmacy 27 (2), 794-810 , 2023 2023 Citations: 4
Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19-PIMS-grade 3: A Case Report GL Narasimha, D Girirajasekhar, P Goudanavar, RR Budha, GSN, ... Coronaviruses , 2024 2024 Citations: 3
Multidose studies in rabbits for determining pharmacokinetic and pharmacodynamic interactions of gliclazide with nutraceutical RR BUDHA, S THAAKUR, GSNK RAO, L YAIDIKAR, R MANNE, ... International Journal of Pharmaceutical Research 13 (1) , 2021 2021 Citations: 3
Impact of climate change on soil loss in Mudhole Watershed of Telangana using GIS and RUSLE RS Rani, R Rejani, GM Kumar, YS Lakshmi, S DK Indian Journal of Dryland Agricultural Research and Development 34 (1), 47-52 , 2019 2019 Citations: 3
Protein Binding Prediction by Computational Methods R Mondal, D Paliwal, A Thakur, R Sahu, RR Budha Applications of Computational Tools in Drug Design and Development, 427-473 , 2025 2025 Citations: 2
Diagnostic and Surgical Uses of Explainable AI (XAI) RR Budha, SWAM Khan, T Lokhande, GSNK Rao, S Aaghaz Explainable and Responsible Artificial Intelligence in Healthcare, 65-88 , 2025 2025 Citations: 2
Pediatric Diffuse High-Grade Gliomas: A Comprehensive Review Of Advanced Methods Of Diagnosis And Treatment RR Budha, SWAM Khan, DC Sharma, Y Kulchandani, KR Gsn Current Cancer Drug Targets , 2025 2025 Citations: 2
Exploring Nano‐Based Therapeutics by Quantum Computational Modeling PT Kumar, RR Budha, GR Kumar, B Nagamani, GSNK Rao Drug Delivery Systems Using Quantum Computing, 93-139 , 2024 2024 Citations: 2
Quantum Computational Methods and Computer‐Aided Drug Design in Transdermal Drug Delivery of Nanoparticles J Mohammed, H Lanka, RR Budha, RR Alavala, GSNK Rao, S Kovvasu Drug Delivery Systems Using Quantum Computing, 231-246 , 2024 2024 Citations: 2
Quantum dots in diagnostic imaging GSNK Rao, RR Alavala, P Sivadasu, RR Budha, KS Yadav Green Sustainable Process for Chemical and Environmental Engineering and … , 2023 2023 Citations: 2
Bionanocomposites in Nasal Drug Delivery RSR Alavala, SNKR Gudhanti, SH Nagaraja, D Karbhari, RR Budha, ... Bionanocomposites for Biomedical Applications, 176-199 , 2026 2026 Citations: 1
Advances in the Computational Prediction of Absorption Prediction of Pharmaceuticals SWAM Khan, A Pandey, S Mishra, RR Budha, SNKR G Applications of Computational Tools in Drug Design and Development, 387-425 , 2025 2025 Citations: 1