Rishabh Kaundal

Scopus Publications

Integrative metabolomic and nanoformulation-based evaluation of Valeriana jatamansi jones: Organ-specific chemogeographical diversity and antioxidant potential
Bindu Rawat, Rishabh Bhardwaj, Rishabh Kaundal, Sachin Vashisath, Anil Kumar, et al.
Plant Nano Biology, 2026
Valeriana jatamansi (Valerian, Mushkbala) is a high value medicinal plant of Himalayan region especially India, China, Nepal and Pakistan. V. jatamansi is utilized for health benefits from many centuries and documented majorly in Indian, and Chinese System of Medicine. Continuous research on the development, adaptation, & quality concerns directed us to investigate comprehensive chemistry of V. jatamansi (roots, stems, flowers and leaves,) collected from six locations of Indian western Himalayas. For volatile chemistry, HS-GC/MS and GC-MS of extracts were used. GC-MS analysis identified 99 different volatile metabolites which represented around 75.2-92.3% of the total samples. The samples majorly contain monoterpenes (56.5-95.0%), oxygenated monoterpenes (0.6-17.6%), sesquiterpenes (0.8-8.0%) and oxygenated (0.2-13.4%) sesquiterpene hydrocarbons with α -pinene (5.6-42.9%) and sabinene as the major component. In non-volatile profiling, targeted amino acids and polyphenols were profiled through UPLC-PDA method. Rutin was quantified predominant polyphenol, while histidine was the most abundant amino acid among all the parts. Whereas, for the simultaneous profiling of major non-volatile marker molecules (valepotriates; hydroxyl valerenic acid, acetoxyvalerenic acid, acevaltrate, didrovaltrate, valerenic acid, valtrate), a reproducible, stable UPLC-PDA method was developed and validated as per ICH guidelines. The validated method revealed the presence of valepotriate that includes valtrate as most abundant valepotriate, followed by didrovaltrate and acevaltrate among the different samples of V. jatamansi . Further, development of V. jatamansi extract-loaded nanosponges demonstrates the potential of nanotechnology in enhancing the stability and delivery of plant-based therapeutics. Current research revealed organ specific chemogeographical variation qualitative and quantitative variations of V. jatamansi samples. These findings highlighted the potential of V. jatamansi and suggested the direction towards the conservation strategies for quality produce of future benefits.
Metabolome Analysis and Functional Activities of Euphorbia royleana Boiss. Indicating Potential Health Benefits
Pallavi Kumari, Rishabh Kaundal, Rajender Kumar, Yogesh Kumar Walia, Dinesh Kumar
Chemistry and Biodiversity, 2026
Euphorbia royleana (Euphorbiaceae) is an important succulent species and commonly known as Royle's spurge. It is used to treat inflammation, paralysis, and brain‐related problems. The literature revealed that E. royleana was not well explored for phytochemical diversity and health benefits. Therefore, the current study was focused on investigating solvent‐dependent chemical diversity and bioactive properties across stems, leaves, and reproductive tissue (flowers and seeds). Ethanol, 50% ethanol, and water extracts were prepared, in which the water extract of leaves showed the highest extraction efficiency (16.97%). Total phenolic content was found higher in 50% ethanol extract (112.65 ± 3.27 mg GAE/g), while flavonoid content was found higher in ethanol extract (217.31 ± 13.55 mg RE/g) of reproductive parts. Further, UPLC‐PDA‐based targeted polyphenol profiling showed gallic acid (23.658 ± mg/g) as the most abundant polyphenol among different parts. UHPLC‐QTOF‐IMS‐based non‐targeted metabolite profiling revealed 74 metabolites (terpenoids, flavonoid glycosides, and phenylpropanoids). Multivariate statistical analysis of identified metabolites further suggested clear organ‐ and solvent‐specific variations. Moreover, antioxidant and tyrosinase inhibition activities were performed, and the highest activity was found in the ethanol extract of reproductive tissues. The current study provides new insights into the chemical diversity of E. royleana , highlighting its ecological significance and chemotaxonomic value within Euphorbiaceae.
Fermentation induced changes in physicochemical properties, antioxidant activity, total sugars, and comprehensive polyphenolic profiles of the Rhododendron-infused wine blends
Archit Awasthi, Anupama Sandal, Rishi Mahajan, Rishabh Kaundal, Neha Sharma, et al.
Food Chemistry, 2025
Comprehensive UHPLC-Q-TOF-IMS based non-targeted metabolome analysis of Rhynchostylis retusa. L Blume revealed chemometric variations. A case study from Western Himalayas
Anjna Kumari, Rishabh Kaundal, Pallavi Kumari, Dinesh Kumar
Biochemical Systematics and Ecology, 2025
Validated UPLC-PDA method for concurrent estimation of polyphenols and anti-inflammatory evaluation of edible Viola canescens. Wall. x Roxb
Rishabh Kaundal, Anil Kumar, Avisha Sharma, Rajender Kumar, Narendra Vijay Tirpude, et al.
Food and Humanity, 2025
Current demands for standardization of Indian medicinal plants: A critical review
Rishabh Kaundal, Dinesh Kumar
Medicine in Drug Discovery, 2025
The resurgence of interest in natural products and traditional medicines offers promising avenues for drug discovery. Medicinal plants’ novel chemical and molecular entities dominate current pharmaceutical research. India has mega biodiversity, including medicinal plants that contribute to drug development and health care via traditional practices. Due to the huge demand, a false practice, and quality issues have been observed in the market. Therefore, comprehensive information about standardization methods and processes are the need of hours to maintain quality of raw materials and final products. Thus, the current review insights the significant role of traditional medicines in India, where over 80 % of the population relies on traditional and folklore practices for healthcare needs. This review also summarizes several standardization parameters, including stepwise pharmacognostic studies, WHO guidelines and official pharmacopeia standards. Published literature suggests that research on medicinal plants needs to be encouraged by governments through good policies, regulations, and trade standards of global market. The reviewed information will provide a foundation to develop monographs and quality parameters for Indian traditional drugs and herbal pharmacopoeia.
Optimized extraction technique and solvent to enhance the recovery of bioactive polyphenols from Viola canescens wall. Ex Roxb. A case study using OFAT and chemical characterization using UPLC-PDA, UHPLC-Q-TOF-IMS and GC–MS
Rishabh Kaundal, Rajender Kumar, Dinesh Kumar
Microchemical Journal, 2025
Impact of Geographical Distribution on Chemical Composition and Biological Potential of Juniperus communis L. Essential Oil: A Case Study From Western Himalayas
Sachin Vashisath, Rishabh Kaundal, Aman Kumar, Rishabh Bhardwaj, Singh Pragati Shesh, et al.
Chemistry and Biodiversity, 2025
The current study was focused to assess the impact of geographical distribution (1325–3200 m, asl) on essential oils (EOs) yield, chemical composition, and biological activities of Juniperus communis leaves. Soil mineral content was also analyzed to understand its impact on chemical composition. EO yield variations were observed (0.22%–0.48%), with highest in J. communis collected from Thatri Dhaar (JCTH) (0.48%) sample. Further, refractive index, specific gravity, and optical rotation of EOs revealed notable differences among the samples. Six trace elements in soils were found, with iron being the most abundant at all locations. Total phenolic and flavonoid content indicated significant variations, with highest total phenolic content (TPC) in JCTH (6.100 ± 0.649 mg GAE/g) sample, whereas total flavonoid content (TFC) was in J. communis collected from Mooring (JCM) (1.126 ± 0.004 mgRE/g) sample. GC and GC/MS‐based metabolite profiling had shown overall thirty metabolites, including terpenes and monoterpene hydrocarbons. Free radical scavenging assays showed strong antioxidant activity of JCCI and JCTH samples (IC 50 ‐ABTS = 4.222 ± 0.166 µg/mL and IC 50 ‐DPPH = 3.211 ± 0.307 µg/mL, respectively). Moreover, EOs significantly inhibit α‐ glucosidase and α ‐amylase enzymes, Gram‐positive and Grnegative bacterial strains. These findings suggested its promising biological potential. Furthermore, identified metabolites‐based statistical analysis (principal component analysis [PCA] and hierarchical clustering analysis [HCA]) highlighted similarities and discriminations of geographically impacted samples. This research will be helpful to understand the metabolite composition and their accumulation under different environmental conditions.
Viola species of western Himalayas as a potential medicinal spice for health benefits: A comprehensive review on ethnobotany, pharmacology and phytochemistry
Rishabh Kaundal, Dinesh Kumar
Pharmacological Research Natural Products, 2025
Polygonatum verticillatum (L.) All.: Systematic information on ethnomedicine, phytochemistry and pharmacological properties
Shruti Sharma, Rishabh Kaundal, Dinesh Kumar
Indian Journal of Natural Products and Resources, 2025
Polygonatum verticillatum (L.) All. is a perennial herb commonly known as whorled solomons seal belonging to the Asparagaceae family and has a long history of uses in folklore and Indian and Chinese systems of medicine. The P. verticillatum is categorised under Astavarga group of drugs. It is widespread in Europe, China, Pakistan, and the Western Himalayas of India. Aerial and rhizome parts of the plant exhibit antipyretic, anticonvulsant, antimalarial, and antioxidant activities and are also used to treat spermopiotic, burning sensation, phthisis and urine-related problems. The aim of this review is to provide a systematic update on the ethnomedicinal and pharmacological uses, chemistry and formulations of P. verticillatum. Exhaustive bibliographic research has been carried out by different search engines like Sci Finder, Google Scholar, Scopus-Elsevier, various chemical abstracts, Medline, Web of Science, Directory of Open Access Journal (DOAJ) from inception until November 2024. In addition, books, non-English journals, and local literature were reviewed and included. As per the scientific literature, P. verticillatum has been reported to have less than thirty compounds, while the genus is reported to contain more than 116 compounds. A systematic update on P. verticillatum has been discussed with the aim of highlighting the importance of this plant.
Development and validation of a rapid and accurate ultra performance liquid chromatography-photodiode array method for concurrent quantification of thirty-two polyphenols in edible fruit of Cordia myxa Linn
Anil Kumar, Rishabh Kaundal, Dinesh Kumar
Journal of Chromatography A, 2025
Indian Traditional Medicine: A Medical Inheritance
Dinesh Kumar, Rishabh Kaundal
Innovations in Ayurvedic Nutrition Principles and Concepts, 2025
Cloud point extraction, antioxidant, α-glucosidase, and tyrosinase enzyme inhibition activities of Allium semenovii Regel
Rajender Kumar, Rishabh Kaundal, Dinesh Kumar
Separation Science and Technology Philadelphia, 2025
Isolation and characterisation of acetylcholinesterase, tyrosinase enzyme, and free radical inhibitors from aerial part of Allium semenovii Regel
Rajender Kumar, Sweety Rana, Rishabh Kaundal, Dinesh Kumar
Natural Product Research, 2025
Chemistry and Biotechnological Insights of Rhynchostylis retusa (L.) Blume: A Mini-Review
Anjna Kumari, Rishabh Kaundal, Tina Roy, Yogesh Kumar Walia, Dinesh Kumar
Current Bioactive Compounds, 2025
Comprehensive polyphenolic profiling, antioxidant, antimicrobial, and cytotoxicity studies of Rhynchostylis retusa (L.) Blume: a medicinal orchid
Anjna Kumari, Rishabh Kaundal, Smita Kapoor, Subhash Kumar, Dharam Singh, et al.
Natural Product Research, 2025
Underutilized edible Himalayan herb, Viola canescens Wall.; chemical composition, antioxidant and antimicrobial activity against respiratory tract pathogens
Rishabh Kaundal, Subhash Kumar, Dharam Singh, Dinesh Kumar
Food Bioscience, 2024
Impact of geographical distribution on polyphenol compostion, antioxidant, antimicrobial and cytotoxic potential of Rhynchostylis retusa (L.) Blume roots
Anjna Kumari, Rishabh Kaundal, Smita Kapoor, Subhash Kumar, Dharam Singh, et al.
Pharmacological Research Natural Products, 2024
Polyphenolic Profiling, Antioxidant, and Antimicrobial Activities Revealed the Quality and Adaptive Behavior of Viola Species, a Dietary Spice in the Himalayas
Rishabh Kaundal, Manish Kumar, Subhash Kumar, Dharam Singh, Dinesh Kumar
Molecules, 2022

RECENT SCHOLAR PUBLICATIONS

Integrative metabolomic and nanoformulation-based evaluation of Valeriana jatamansi jones: Organ-specific chemogeographical diversity and antioxidant potential
B Rawat, R Bhardwaj, R Kaundal, S Vashisath, A Kumar, R Kumar, ...
Plant Nano Biology 17, 100309 , 2026
2026
Isolation, chemophenetic profiling, antibacterial activity, and in silico pharmacokinetic-toxicological evaluation of secondary metabolites from Viola canescens Wall. ex Roxb.
R Kaundal, R Kumar, A Kumar, AM Pati, D Kumar
In Silico Research in Biomedicine, 100368 , 2026
2026
Metabolome Analysis and Functional Activities of Euphorbia royleana Boiss. Indicating Potential Health Benefits
P Kumari, R Kaundal, R Kumar, YK Walia, D Kumar
Chemistry & Biodiversity 23 (3), e03217 , 2026
2026
Comprehensive UHPLC-Q-TOF-IMS based non-targeted metabolome analysis of Rhynchostylis retusa. L Blume revealed chemometric variations. A case study from Western Himalayas
A Kumari, R Kaundal, P Kumari, D Kumar
Biochemical Systematics and Ecology 123, 105092 , 2025
2025
Citations: 1
Cloud point extraction, antioxidant, α -glucosidase, and tyrosinase enzyme inhibition activities of Allium semenovii Regel
R Kumar, R Kaundal, D Kumar
Separation Science and Technology 60 (17), 2518-2527 , 2025
2025
Comprehensive polyphenolic profiling, antioxidant, antimicrobial, and cytotoxicity studies of Rhynchostylis retusa (L.) Blume: a medicinal orchid
A Kumari, R Kaundal, S Kapoor, S Kumar, D Singh, Y Kumar Walia, ...
Natural Product Research 39 (22), 6361-6368 , 2025
2025
Citations: 10
Fermentation induced changes in physicochemical properties, antioxidant activity, total sugars, and comprehensive polyphenolic profiles of the Rhododendron-infused wine blends
A Awasthi, A Sandal, R Mahajan, R Kaundal, N Sharma, S Sharma
Food Chemistry, 146743 , 2025
2025
Indian Traditional Medicine: A Medical Inheritance
D Kumar, R Kaundal
Innovations in Ayurvedic Nutrition: Principles and Concepts, 197-214 , 2025
2025
Isolation and characterisation of acetylcholinesterase, tyrosinase enzyme, and free radical inhibitors from aerial part of Allium semenovii Regel
R Kumar, S Rana, R Kaundal, D Kumar
Natural Product Research, 1-7 , 2025
2025
Citations: 1
Validated UPLC-PDA method for concurrent estimation of polyphenols and anti-inflammatory evaluation of edible Viola canescens. Wall. x Roxb
R Kaundal, A Kumar, A Sharma, R Kumar, NV Tirpude, D Kumar
Food and Humanity, 100790 , 2025
2025
Current demands for standardization of Indian medicinal plants: A critical review
R Kaundal, D Kumar
Medicine in Drug Discovery 27, 100211 , 2025
2025
Citations: 26
Optimized extraction technique and solvent to enhance the recovery of bioactive polyphenols from Viola canescens wall. Ex Roxb. A case study using OFAT and chemical …
R Kaundal, R Kumar, D Kumar
Microchemical Journal 212, 113170 , 2025
2025
Citations: 6
Impact of Geographical Distribution on Chemical Composition and Biological Potential of Juniperus communis L. Essential Oil: A Case Study From Western …
S Vashisath, R Kaundal, A Kumar, R Bhardwaj, SP Shesh, A Bhatt, ...
Chemistry & Biodiversity 22 (4), e202402564 , 2025
2025
Citations: 5
Polygonatum verticillatum (L.) All.: Systematic information on ethnomedicine, phytochemistry and pharmacological properties
S Sharma, R Kaundal, D Kumar
Indian Journal of Natural Products and Resources (IJNPR)[Formerly Natural … , 2025
2025
Viola species of western Himalayas as a potential medicinal spice for health benefits: A comprehensive review on ethnobotany, pharmacology and phytochemistry
R Kaundal, D Kumar
Pharmacological Research-Natural Products 6, 100179 , 2025
2025
Citations: 4
Development and validation of a rapid and accurate ultra performance liquid chromatography-photodiode array method for concurrent quantification of thirty-two polyphenols in …
A Kumar, R Kaundal, D Kumar
Journal of Chromatography A 1743, 465609 , 2025
2025
Citations: 8
Underutilized edible Himalayan herb, Viola canescens Wall.; chemical composition, antioxidant and antimicrobial activity against respiratory tract pathogens
R Kaundal, S Kumar, D Singh, D Kumar
Food Bioscience 62, 105201 , 2024
2024
Citations: 14
Chemistry and Biotechnological Insights of Rhynchostylis retusa (L.) Blume: A Mini-Review
YKWDK Anjna Kumari, Rishabh Kaundal, Tina Roy
Current Bioactive Compounds , 2024
2024
Citations: 1
Impact of geographical distribution on polyphenol compostion, antioxidant, antimicrobial and cytotoxic potential of Rhynchostylis retusa (L.) Blume roots
A Kumari, R Kaundal, S Kapoor, S Kumar, D Singh, YK Walia, D Kumar
Pharmacological Research-Natural Products 4, 100084 , 2024
2024
Citations: 2
Polyphenolic profiling, antioxidant, and antimicrobial activities revealed the quality and adaptive behavior of viola species, a dietary spice in the himalayas
R Kaundal, M Kumar, S Kumar, D Singh, D Kumar
Molecules 27 (12), 3867 , 2022
2022
Citations: 36

MOST CITED SCHOLAR PUBLICATIONS

Polyphenolic profiling, antioxidant, and antimicrobial activities revealed the quality and adaptive behavior of viola species, a dietary spice in the himalayas
R Kaundal, M Kumar, S Kumar, D Singh, D Kumar
Molecules 27 (12), 3867 , 2022
2022
Citations: 36
Current demands for standardization of Indian medicinal plants: A critical review
R Kaundal, D Kumar
Medicine in Drug Discovery 27, 100211 , 2025
2025
Citations: 26
Underutilized edible Himalayan herb, Viola canescens Wall.; chemical composition, antioxidant and antimicrobial activity against respiratory tract pathogens
R Kaundal, S Kumar, D Singh, D Kumar
Food Bioscience 62, 105201 , 2024
2024
Citations: 14
Comprehensive polyphenolic profiling, antioxidant, antimicrobial, and cytotoxicity studies of Rhynchostylis retusa (L.) Blume: a medicinal orchid
A Kumari, R Kaundal, S Kapoor, S Kumar, D Singh, Y Kumar Walia, ...
Natural Product Research 39 (22), 6361-6368 , 2025
2025
Citations: 10
Development and validation of a rapid and accurate ultra performance liquid chromatography-photodiode array method for concurrent quantification of thirty-two polyphenols in …
A Kumar, R Kaundal, D Kumar
Journal of Chromatography A 1743, 465609 , 2025
2025
Citations: 8
Optimized extraction technique and solvent to enhance the recovery of bioactive polyphenols from Viola canescens wall. Ex Roxb. A case study using OFAT and chemical …
R Kaundal, R Kumar, D Kumar
Microchemical Journal 212, 113170 , 2025
2025
Citations: 6
Impact of Geographical Distribution on Chemical Composition and Biological Potential of Juniperus communis L. Essential Oil: A Case Study From Western …
S Vashisath, R Kaundal, A Kumar, R Bhardwaj, SP Shesh, A Bhatt, ...
Chemistry & Biodiversity 22 (4), e202402564 , 2025
2025
Citations: 5
Viola species of western Himalayas as a potential medicinal spice for health benefits: A comprehensive review on ethnobotany, pharmacology and phytochemistry
R Kaundal, D Kumar
Pharmacological Research-Natural Products 6, 100179 , 2025
2025
Citations: 4
Impact of geographical distribution on polyphenol compostion, antioxidant, antimicrobial and cytotoxic potential of Rhynchostylis retusa (L.) Blume roots
A Kumari, R Kaundal, S Kapoor, S Kumar, D Singh, YK Walia, D Kumar
Pharmacological Research-Natural Products 4, 100084 , 2024
2024
Citations: 2
Comprehensive UHPLC-Q-TOF-IMS based non-targeted metabolome analysis of Rhynchostylis retusa. L Blume revealed chemometric variations. A case study from Western Himalayas
A Kumari, R Kaundal, P Kumari, D Kumar
Biochemical Systematics and Ecology 123, 105092 , 2025
2025
Citations: 1
Isolation and characterisation of acetylcholinesterase, tyrosinase enzyme, and free radical inhibitors from aerial part of Allium semenovii Regel
R Kumar, S Rana, R Kaundal, D Kumar
Natural Product Research, 1-7 , 2025
2025
Citations: 1
Chemistry and Biotechnological Insights of Rhynchostylis retusa (L.) Blume: A Mini-Review
YKWDK Anjna Kumari, Rishabh Kaundal, Tina Roy
Current Bioactive Compounds , 2024
2024
Citations: 1
Integrative metabolomic and nanoformulation-based evaluation of Valeriana jatamansi jones: Organ-specific chemogeographical diversity and antioxidant potential
B Rawat, R Bhardwaj, R Kaundal, S Vashisath, A Kumar, R Kumar, ...
Plant Nano Biology 17, 100309 , 2026
2026
Isolation, chemophenetic profiling, antibacterial activity, and in silico pharmacokinetic-toxicological evaluation of secondary metabolites from Viola canescens Wall. ex Roxb.
R Kaundal, R Kumar, A Kumar, AM Pati, D Kumar
In Silico Research in Biomedicine, 100368 , 2026
2026
Metabolome Analysis and Functional Activities of Euphorbia royleana Boiss. Indicating Potential Health Benefits
P Kumari, R Kaundal, R Kumar, YK Walia, D Kumar
Chemistry & Biodiversity 23 (3), e03217 , 2026
2026
Cloud point extraction, antioxidant, α -glucosidase, and tyrosinase enzyme inhibition activities of Allium semenovii Regel
R Kumar, R Kaundal, D Kumar
Separation Science and Technology 60 (17), 2518-2527 , 2025
2025
Fermentation induced changes in physicochemical properties, antioxidant activity, total sugars, and comprehensive polyphenolic profiles of the Rhododendron-infused wine blends
A Awasthi, A Sandal, R Mahajan, R Kaundal, N Sharma, S Sharma
Food Chemistry, 146743 , 2025
2025
Indian Traditional Medicine: A Medical Inheritance
D Kumar, R Kaundal
Innovations in Ayurvedic Nutrition: Principles and Concepts, 197-214 , 2025
2025
Validated UPLC-PDA method for concurrent estimation of polyphenols and anti-inflammatory evaluation of edible Viola canescens. Wall. x Roxb
R Kaundal, A Kumar, A Sharma, R Kumar, NV Tirpude, D Kumar
Food and Humanity, 100790 , 2025
2025
Polygonatum verticillatum (L.) All.: Systematic information on ethnomedicine, phytochemistry and pharmacological properties
S Sharma, R Kaundal, D Kumar
Indian Journal of Natural Products and Resources (IJNPR)[Formerly Natural … , 2025
2025