Biochemistry, Genetics and Molecular Biology, Cancer Research, General Biochemistry, Genetics and Molecular Biology, Molecular Biology
1
Scopus Publications
448
Scholar Citations
10
Scholar h-index
10
Scholar i10-index
Scopus Publications
Uncovering the Role of DNA Repair Impairment in UVA-Induced Mutagenesis in Human Xeroderma Pigmentosum Variant Cells Camila Corradi, Natália Cestari Moreno, Nathalia Quintero‐Ruiz, Giovana da Silva Leandro, Marcela Teatin Latancia, Tiago Antonio de Souza, Veridiana Munford, Carlos Frederico Martins Menck Molecular Carcinogenesis, 2025 Ultraviolet A (UVA) radiation induces DNA damage both directly, by forming cyclobutane pyrimidine dimers (CPDs), and indirectly, by generating oxidative stress. Cells rely on nucleotide excision repair (NER) and translesion synthesis (TLS) to tolerate these lesions. Xeroderma pigmentosum variant (XP‐V) cells, deficient in DNA polymerase eta (pol eta), exhibit a heightened risk of skin cancer due to impaired TLS. While XP‐V patients are considered NER‐proficient, our findings challenge this assumption by demonstrating that UVA‐induced oxidative stress impaired NER activity, leading to increased C > T transitions at CPD sites. Whole‐exome sequencing of UVA‐irradiated XP‐V cells revealed a substantial rise in mutations, with a distinct C > T signature characteristic of defective CPD repair. Notably, pretreatment with the antioxidant N‐acetylcysteine (NAC) mitigated this effect, reducing C > T transitions through enhanced NER function and decreasing C > A transversions via its antioxidant properties. These results redefine the mutagenic landscape of XP‐V cells, revealing that oxidatively generated damage to NER proteins—rather than TLS deficiency alone—contributes to their elevated mutation burden. Our findings suggest that antioxidant strategies may partially protect XP‐V patients from UVA‐driven mutagenesis enhancing the cells' DNA repair capacity, ultimately reducing skin cancer and contributing to better overall health outcomes.
RECENT SCHOLAR PUBLICATIONS
Activation of Escherichia coli RecA* in recA730 lexA+ and recA730 lexA (Def) strain backgrounds JP McDonald, JC Selod, MT Latancia, R Woodgate DNA repair 161, 103933 , 2026 2026
Human DNA polymerase η is regulated by mutually exclusive mono-ubiquitination and mono-NEDDylation NC Moreno, EJ Korchak, MT Latancia, DA D’Orlando, T Adegbenro, ... Nucleic Acids Research 54 (4), gkag098 , 2026 2026
Combinational BET and mTOR inhibition unveils EGR1 as acute myeloid leukemia prognostic biomarker MT Latancia, WF Silva, E Bragança-Jardim, FF Terra, PF Asprino, ... Scientific Reports 15 (1), 40557 , 2025 2025 Citations: 1
Uncovering the Role of DNA Repair Impairment in UVA‐Induced Mutagenesis in Human Xeroderma Pigmentosum Variant Cells C Corradi, NC Moreno, N Quintero‐Ruiz, G Silva Leandro, ... Molecular Carcinogenesis 64 (11), 1823-1837 , 2025 2025
Mapping the Genetic Achilles' Heel: Synthetic Lethality in Colon Cancer POLI KO Cells MT Latancia, W Roger ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 66, 106-106 , 2025 2025
DNA polymerase η is regulated by mutually exclusive mono-ubiquitination and mono-NEDDylation NC Moreno, EJ Korchak, MT Latancia, DA D’Orlando, T Adegbenro, ... bioRxiv , 2024 2024 Citations: 1
Human translesion DNA polymerases ι and κ mediate tolerance to temozolomide in MGMT-deficient glioblastoma cells. MT Latancia, G da Silva Leandro, AU Bastos, NC Moreno, ABA Ariwoola, ... DNA repair 141, 103715 , 2024 2024 Citations: 6
The role of chaperone-mediated autophagy in drug resistance ABS Teixeira, MCC Ramalho, I Souza, IAM Andrade, IYA Osawa, ... Genetics and Molecular Biology 47 (Suppl 1), e20230317 , 2024 2024 Citations: 6
Temozolomide resistance mechanisms: unveiling the role of translesion DNA polymerase kappa in glioblastoma spheroids in vitro DL Ribeiro, MT Latancia, I de Souza, ABA Ariwoola, D Mendes, ... Bioscience Reports 44 (5), BSR20230667 , 2024 2024 Citations: 6
A novel interaction between RAD23A/B and Y-family DNA polymerases NW Ashton, N Jaiswal, NC Moreno, IV Semenova, DA D'Orlando, ... Journal of molecular biology 435 (24), 168353 , 2023 2023 Citations: 9
DNA polymerase eta is a new substrate of the NEDD8 ubiquitin-like conjugating pathway NC Moreno, D D'Orlando, MT Latancia, I Bezsonova, NW Ashton, ... ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 64, 90-91 , 2023 2023
Temozolomide resistance in glioblastoma by NRF2: protecting the evil K Almeida Lima, IYA Osawa, MCC Ramalho, I de Souza, CB Guedes, ... Biomedicines 11 (4), 1081 , 2023 2023 Citations: 38
Epigenetics and DNA Damage MG Jasiulionis Academic Press , 2022 2022 Citations: 4
Unraveling DNA Polymerases Iota, Kappa and Eta Roles on Temozolomide Treatment MT Latancia, NC Moreno, G Leandro, AU Bastos, D Jardim, I Souza, ... ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 63, 17-17 , 2022 2022
Translesion DNA Polymerases in Temozolomide Resistance: Cytotoxic and Antiproliferative Analysis in Glioblastoma Spheroids in vitro DL Ribeiro, MT Latancia, D Mendes, CRR Rocha, CFM Menck ENVIRONMENTAL AND MOLECULAR MUTAGENESIS 63, 103-103 , 2022 2022
High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation I De Souza, LKS Monteiro, CB Guedes, MM Silva, M Andrade-Tomaz, ... Cell death & disease 13 (7), 591 , 2022 2022 Citations: 104
Temozolomide-resistant glioblastoma cells are collaterally sensitive to ferroptosis through NRF2 high expression I de Souza, LK Monteiro, CB Guedes, M Latancia, MT Andrade, MM Silva, ... Cancer Research 82 (12_Supplement), 5360-5360 , 2022 2022
DNA polymerase eta protects human cells against DNA damage induced by the tumor chemotherapeutic temozolomide MT Latancia, NC Moreno, GS Leandro, VC Ribeiro, I de Souza, ... Mutation Research/Genetic Toxicology and Environmental Mutagenesis 878, 503498 , 2022 2022 Citations: 13
High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation, Cell Death Dis., 13, 591 I de Souza, LKS Monteiro, CB Guedes, MM Silva, M Andrade-Tomaz, ... 2022 Citations: 4
Papel Da Síntese Translesão Na Resistência À Cisplatina E TMZ Em Células De Glioma. MT Latancia Universidade de São Paulo , 2022 2022
MOST CITED SCHOLAR PUBLICATIONS
High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation I De Souza, LKS Monteiro, CB Guedes, MM Silva, M Andrade-Tomaz, ... Cell death & disease 13 (7), 591 , 2022 2022.0 Citations: 104
Dectin-1 activation exacerbates obesity and insulin resistance in the absence of MyD88 A Castoldi, V Andrade-Oliveira, CF Aguiar, MT Amano, J Lee, MT Miyagi, ... Cell reports 19 (11), 2272-2288 , 2017 2017.0 Citations: 67
Revealing temozolomide resistance mechanisms via genome-wide CRISPR libraries CRR Rocha, AR Rocha, MM Silva, LR Gomes, MT Latancia, ... Cells 9 (12), 2573 , 2020 2020.0 Citations: 48
Temozolomide resistance in glioblastoma by NRF2: protecting the evil K Almeida Lima, IYA Osawa, MCC Ramalho, I de Souza, CB Guedes, ... Biomedicines 11 (4), 1081 , 2023 2023.0 Citations: 38
DNA Photodamage R Improta, T Douki Royal Society of Chemistry , 2021 2021.0 Citations: 35
Update on renal replacement therapy: implantable artificial devices and bioengineered organs C Attanasio, MT Latancia, LE Otterbein, PA Netti Tissue Engineering Part B: Reviews 22 (4), 330-340 , 2016 2016.0 Citations: 27
Physical exercise contributes to cisplatin-induced nephrotoxicity protection with decreased CD4+ T cells activation MYS Miyagi, MT Latancia, LA Testagrossa, V de Andrade-Oliveira, ... Molecular immunology 101, 507-513 , 2018 2018.0 Citations: 26
The lack of PI3Kγ favors M1 macrophage polarization and does not prevent kidney diseases progression MT Amano, A Castoldi, V Andrade-Oliveira, MT Latancia, FF Terra, ... International immunopharmacology 64, 151-161 , 2018 2018.0 Citations: 25
DNA polymerase eta protects human cells against DNA damage induced by the tumor chemotherapeutic temozolomide MT Latancia, NC Moreno, GS Leandro, VC Ribeiro, I de Souza, ... Mutation Research/Genetic Toxicology and Environmental Mutagenesis 878, 503498 , 2022 2022.0 Citations: 13
The first report of molecular characterized BRD4-NUT carcinoma in Brazil: a case report LJC Oliveira, ABL Gongora, MT Latancia, FG Barbosa, JVAM Gregorio, ... Journal of Medical Case Reports 13 (1), 279 , 2019 2019.0 Citations: 12
A novel interaction between RAD23A/B and Y-family DNA polymerases NW Ashton, N Jaiswal, NC Moreno, IV Semenova, DA D'Orlando, ... Journal of molecular biology 435 (24), 168353 , 2023 2023.0 Citations: 9
Loss of mtorc2 activity in neutrophils impairs fusion of granules and affects cellular metabolism favoring increased bacterial burden in sepsis CNS Breda, LCD Breda, LAC Carvalho, MT Amano, FF Terra, RC Silva, ... The Journal of Immunology 207 (2), 626-639 , 2021 2021.0 Citations: 7
Human translesion DNA polymerases ι and κ mediate tolerance to temozolomide in MGMT-deficient glioblastoma cells. MT Latancia, G da Silva Leandro, AU Bastos, NC Moreno, ABA Ariwoola, ... DNA repair 141, 103715 , 2024 2024.0 Citations: 6
The role of chaperone-mediated autophagy in drug resistance ABS Teixeira, MCC Ramalho, I Souza, IAM Andrade, IYA Osawa, ... Genetics and Molecular Biology 47 (Suppl 1), e20230317 , 2024 2024.0 Citations: 6
Temozolomide resistance mechanisms: unveiling the role of translesion DNA polymerase kappa in glioblastoma spheroids in vitro DL Ribeiro, MT Latancia, I de Souza, ABA Ariwoola, D Mendes, ... Bioscience Reports 44 (5), BSR20230667 , 2024 2024.0 Citations: 6
Epigenetics and DNA Damage MG Jasiulionis Academic Press , 2022 2022.0 Citations: 4
High levels of NRF2 sensitize temozolomide-resistant glioblastoma cells to ferroptosis via ABCC1/MRP1 upregulation, Cell Death Dis., 13, 591 I de Souza, LKS Monteiro, CB Guedes, MM Silva, M Andrade-Tomaz, ... 2022.0 Citations: 4
How do Translesion Polymerases Deal With Photodamage? NC Moreno, MT Latancia, A Peres de Oliveira, E Padilha, DJ Martins, ... 2021.0 Citations: 3
Dectin-1 activation exacerbates obesity and insulin resistance in the absence of MyD88. Cell Rep. 2017; 19 (11): 2272–88 A Castoldi, V Andrade-Oliveira, CF Aguiar, MT Amano, J Lee, MT Miyagi, ... Citations: 3
Revealing temozolomide resistance mechanisms via genome-wide CRISPR libraries. Cells. 2020 CRR Rocha, AR Rocha, MM Silva, LR Gomes, MT Latancia, ... Citations: 2
