Carla mannu

@multimedica.it

Unità Operativa Endocrinologia, Nutrizione e Malattie Metaboliche Ospedale MultiMedica San Giuseppe
Gruppo Multimedica

Carla mannu


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https://researchid.co/carlamannu

RESEARCH, TEACHING, or OTHER INTERESTS

Endocrinology, Endocrinology, Diabetes and Metabolism, Epidemiology, Molecular Biology
10

Scopus Publications

Scopus Publications

  • Growth and development of islet autoimmunity and type 1 diabetes in children genetically at risk
    Anita M. Nucci, Suvi M. Virtanen, David Cuthbertson, Johnny Ludvigsson, Ulle Einberg, Celine Huot, Luis Castano, Bärbel Aschemeier, Dorothy J. Becker, Mikael Knip, Jeffrey P. Krischer, , Thomas Mandrup-Poulsen, Elias Arjas, Esa Läärä, Åke Lernmark, Barbara Schmidt, Jeffrey P. Krischer, Hans K. Åkerblom, Mila Hyytinen, Mikael Knip, Katriina Koski, Matti Koski, Eeva Pajakkala, Marja Salonen, David Cuthbertson, Jeffrey P. Krischer, Linda Shanker, Brenda Bradley, Hans-Michael Dosch, John Dupré, William Fraser, Margaret Lawson, Jeffrey L. Mahon, Mathew Sermer, Shayne P. Taback, Dorothy Becker, Margaret Franciscus, Anita Nucci, Jerry Palmer, Suvi M. Virtanen, Jacki Catteau, Neville Howard, Patricia Crock, Maria Craig, Cheril L. Clarson, Lynda Bere, David Thompson, Daniel Metzger, Colleen Marshall, Jennifer Kwan, David K. Stephure, Daniele Pacaud, Wendy Schwarz, Rose Girgis, Marilyn Thompson, Shayne P. Taback, Daniel Catte, Margaret L. Lawson, Brenda Bradley, Denis Daneman, Mathew Sermer, Mary-Jean Martin, Valérie Morin, Line Frenette, Suzanne Ferland, Susan Sanderson, Kathy Heath, Céline Huot, Monique Gonthier, Maryse Thibeault, Laurent Legault, Diane Laforte, Elizabeth A. Cummings, Karen Scott, Tracey Bridger, Cheryl Crummell, Robyn Houlden, Adriana Breen, George Carson, Sheila Kelly, Koravangattu Sankaran, Marie Penner, Richard A. White, Nancy King, James Popkin, Laurie Robson, Eva Al Taji, Pavla Mendlova, Martina Romanova, Jan Vavrinec, Jan Vosahlo, Ludmila Brazdova, Jitrenka Venhacova, Petra Venhacova, Adam Cipra, Zdenka Tomsikova, Petra Paterová, Pavla Gogelova, Ülle Einberg, Mall-Anne Riikjärv, Anne Ormisson, Vallo Tillmann, Susanne Johansson, Päivi Kleemola, Anna Parkkola, Anna-Liisa Järvenpää, Anu-Maaria Hämäläinen, Sanne Kiiveri, Maria Salonen, Sirpa Tenhola, Pia Salonen, Eeva Jason, Jenni Selvenius, Heli Siljander, Samuli Ylitalo, Ilkka Paajanen, Timo Talvitie, Kaija Lindström, Hanna Huopio, Jouni Pesola, Riitta Veijola, Päivi Tapanainen, Abram Alar, Erik Popov, Ritva Virransalo, Päivi Nykänen, Bärbel Aschemeier, Thomas Danne, Olga Kordonouri, Dóra Krikovszky, László Madácsy, Yeganeh Manon Khazrai, Ernesto Maddaloni, Paolo Pozzilli, Carla Mannu, Marco Songini, Carine de Beaufort, Ulrike Schierloh, Jan Bruining, Margriet Bisschoff, Aleksander Basiak, Renata Wasikowa, Marta Ciechanowska, Grazyna Deja, Przemyslawa Jarosz-Chobot, Agnieszka Szadkowska, Katarzyna Cypryk, Malgorzata Zawodniak-Szalapska, Luis Castano, Teba Gonzalez Frutos, Mirentxu Oyarzabal, Manuel Serrano-Ríos, María Teresa Martínez-Larrad, Federico Gustavo Hawkins, Dolores Rodriguez Arnau, Johnny Ludvigsson, Malgorzata Smolinska Konefal, Ragnar Hanas, Bengt Lindblad, Nils-Östen Nilsson, Hans Fors, Maria Nordwall, Agne Lindh, Hans Edenwall, Jan Åman, Calle Johansson, Margrit Gadient, Daniel Konrad, Eugen Schoenle, Dorothy Becker, Ashi Daftary, Mary Beth Klein, Carol Gilmour, Jerry Palmer, Patty Malone, Marilyn Tanner-Blasiar, Neil White, Uday Devaskar, Heather Horowitz, Lisa Rogers, Roxana Colon, Teresa Frazer, Jose Torres, Robin Goland, Ellen Greenberg, Holly Schachner, Barney Softness, Jorma Ilonen, Massimo Trucco, Lynn Nichol, Erkki Savilahti, Taina Härkönen, Mikael Knip, Outi Vaarala, Kristiina Luopajärvi, Hans-Michael Dosch
    Diabetologia, 2021
  • Particular device producing ozonated water to treat dentinal sensitivity: a pilot study
    Cinzia Casu, Katia Canafoglia, Carla Mannu, Luca Viganò, G Gupta, et al.
    Letters in Applied Nanobioscience, 2020
    Ozone is aunstable gas, proposed in medicine filed especially for microbial infections. It can be used in the form of oxygen-ozone gas mixture , diluted in aqueous solution and in the form of ozonized oil. Its antimicrobial action is linked to damage to the cytoplasmic membrane, and so it has been proposed in different dentistry fields. The most simple application is ozonated water. The aim of this pilot study is to evaluate the effectiveness on dentinal sensitivity, of a particular device called Aquolab (Sweden & Martina , Padua , Italy), similar to a water-jet, that dispenses a mixture of water and ozone7 patients were enrolled in this pilot study, 4 female patients e 3 male patients with some difficult to eat and drink cold food. An NSR scale test was administered to the patients, to quantify the dentinal sensitivity, on groups of 3-4 dental elements. The values reported were registered. A single session of 60 seconds mixture of water and ozone was performed, with program 1 for water delivery and program 3 for ozone delivery. After the session the NSR scale test was submitted again to the patients. In 3 patients has been possible to record also the values at 1 months follow up.The average of the values found was 7,42 before the treatments and 2,5 immediately after the session with Aquolab. In one patient the value of the test at 1 months follows up was 0,5, the same that after the treatment. In another patient the value was 1 after the session and 0 after the 1months follow up; one patient reported the value of 4 at the follow up visit. All patients had improved their sensitivity.The use of ozonized water for oral infections treatment is successfully documented in the literature but there is no work on the use of this garrison to reduce this problem. This device could be considered useful to treat dentinal sensitivity without any type of collateral events. More clinical studies are needed to confirm this preliminary results.
  • Effect of hydrolyzed infant formula vs conventional formula on risk of type 1 diabetes the TRIGR randomized clinical trial
    , Mikael Knip, Hans K. Åkerblom, Eva Al Taji, Dorothy Becker, Jan Bruining, Luis Castano, Thomas Danne, Carine de Beaufort, Hans-Michael Dosch, John Dupre, William D. Fraser, Neville Howard, Jorma Ilonen, Daniel Konrad, Olga Kordonouri, Jeffrey P. Krischer, Margaret L. Lawson, Johnny Ludvigsson, Laszlo Madacsy, Jeffrey L. Mahon, Anne Ormisson, Jerry P. Palmer, Paolo Pozzilli, Erkki Savilahti, Manuel Serrano-Rios, Marco Songini, Shayne Taback, Outi Vaarala, Neil H. White, Suvi M. Virtanen, Renata Wasikowa
    JAMA, 2018
    Importance Early exposure to complex dietary proteins may increase the risk of type 1 diabetes in children with genetic disease susceptibility. There are no intact proteins in extensively hydrolyzed formulas. Objective To test the hypothesis that weaning to an extensively hydrolyzed formula decreases the cumulative incidence of type 1 diabetes in young children. Design, Setting, and Participants An international double-blind randomized clinical trial of 2159 infants with human leukocyte antigen–conferred disease susceptibility and a first-degree relative with type 1 diabetes recruited from May 2002 to January 2007 in 78 study centers in 15 countries; 1081 were randomized to be weaned to the extensively hydrolyzed casein formula and 1078 to a conventional formula. The follow-up of the participants ended on February 28, 2017. Interventions The participants received either a casein hydrolysate or a conventional adapted cow’s milk formula supplemented with 20% of the casein hydrolysate. The minimum duration of study formula exposure was 60 days by 6 to 8 months of age. Main Outcomes and Measures Primary outcome was type 1 diabetes diagnosed according to World Health Organization criteria. Secondary outcomes included age at diabetes diagnosis and safety (adverse events). Results Among 2159 newborn infants (1021 female [47.3%]) who were randomized, 1744 (80.8%) completed the trial. The participants were observed for a median of 11.5 years (quartile [Q] 1-Q3, 10.2-12.8). The absolute risk of type 1 diabetes was 8.4% among those randomized to the casein hydrolysate (n = 91) vs 7.6% among those randomized to the conventional formula (n = 82) (difference, 0.8% [95% CI, −1.6% to 3.2%]). The hazard ratio for type 1 diabetes adjusted for human leukocyte antigen risk group, duration of breastfeeding, duration of study formula consumption, sex, and region while treating study center as a random effect was 1.1 (95% CI, 0.8 to 1.5; P = .46). The median age at diagnosis of type 1 diabetes was similar in the 2 groups (6.0 years [Q1-Q3, 3.1-8.9] vs 5.8 years [Q1-Q3, 2.6-9.1]; difference, 0.2 years [95% CI, −0.9 to 1.2]). Upper respiratory infections were the most common adverse event reported (frequency, 0.48 events/year in the hydrolysate group and 0.50 events/year in the control group). Conclusions and Relevance Among infants at risk for type 1 diabetes, weaning to a hydrolyzed formula compared with a conventional formula did not reduce the cumulative incidence of type 1 diabetes after median follow-up for 11.5 years. These findings do not support a need to revise the dietary recommendations for infants at risk for type 1 diabetes. Trial Registration clinicaltrials.gov Identifier: NCT00179777
  • Regional differences in milk and complementary feeding patterns in infants participating in an international nutritional type 1 diabetes prevention trial
    Anita M. Nucci, Suvi M. Virtanen, Susa Sorkio, Sonja Bärlund, David Cuthbertson, Ulla Uusitalo, Margaret L. Lawson, Marja Salonen, Carol L. Berseth, Anne Ormisson, Eveliina Lehtonen, Erkki Savilahti, Dorothy J. Becker, John Dupré, Jeffrey P. Krischer, Mikael Knip, Hans K. Åkerblom, and
    Maternal and Child Nutrition, 2017
    Differences in breastfeeding, other milk feeding and complementary feeding patterns were evaluated in infants at increased genetic risk with and without maternal type 1 diabetes (T1D). The Trial to Reduce IDDM in the Genetically at Risk is an international nutritional primary prevention double‐blinded randomized trial to test whether weaning to extensively hydrolyzed vs. intact cow's milk protein formula will decrease the development of T1D‐associated autoantibodies and T1D. Infant diet was prospectively assessed at two visits and seven telephone interviews between birth and 8 months. Countries were grouped into seven regions: Australia, Canada, Northern Europe, Southern Europe, Central Europe I, Central Europe II and the United States. Newborn infants with a first‐degree relative with T1D and increased human leukocyte antigen‐conferred susceptibility to T1D were recruited. A lower proportion of infants born to mothers with than without T1D were breastfed until 6 months of age in all regions (range, 51% to 60% vs. 70% to 80%). Complementary feeding patterns differed more by region than by maternal T1D. In Northern Europe, a higher proportion of infants consumed vegetables and fruits daily compared with other regions. Consumption of meat was more frequent in all European regions, whereas cereal consumption was most frequent in Southern Europe, Canada and the United States. Maternal T1D status was associated with breastfeeding and other milk feeding patterns similarly across regions but was unrelated to the introduction of complementary foods. Infant feeding patterns differed significantly among regions and were largely inconsistent with current recommended guidelines.
  • Atypical Afta Major Healing after Photodynamic Therapy
    Cinzia Casu, Carla Mannu
    Case Reports in Dentistry, 2017
    The aim of this study is to report a case of atypical Afta Major healing in a patient with recurrent aphthous stomatitis (SAR) with a type of photodynamic therapy. A female patient with SAR affected for about 2 years reported a history of hypothyroidism treated with Levothyroxine. The oral cavity clinical examination showed several major symptomatic ulcers, previously treated with topical and systemic therapies without any benefit. The largest of them is present for more than 40 days, in spite of topical cortisone applications, with significant pain symptoms reported by the patient. It was decided to perform a session of photodynamic therapy with a device that emits a LED light used in combination with a photosensitive reagent (Toluidine blue). The dye was applied on the entire surface of the lesion beyond the margins and even encroaching on healthy tissue. The light diode was turned on with a wavelength of 630 nm with cycles from 30 seconds, 10 consecutive times above it. After a few days, a curious phenomenon happened: healing of Afta Major starting from the center, which was almost completely healed towards the borders of the lesion. No previous literature reports this type of healing. Photodynamic therapy could be a successful treatment for SAR.
  • Type 1 diabetes in Sardinia: facts and hypotheses in the context of worldwide epidemiological data
    M. Songini, C. Mannu, C. Targhetta, G. Bruno
    Acta Diabetologica, 2017
  • Recognition of ZnT8, Proinsulin, and Homologous MAP Peptides in Sardinian Children at Risk of T1D Precedes Detection of Classical Islet Antibodies
    Magdalena Niegowska, Daniela Paccagnini, Carla Mannu, Clara Targhetta, Marco Songini, Leonardo A. Sechi
    Journal of Diabetes Research, 2016
    As numerous studies put in evidence the increasing incidence of type 1 diabetes (T1D) in children, an early diagnosis is of great importance to define correct treatment and diet. Currently, the identification of classical islet autoantibodies is the primary biomarker for diagnosis in subjects at risk, especially in pediatric patients. Recent studies suggest that detection of antibodies against ZnT8 protein in preclinical phase can predict the development of T1D. We previously demonstrated a significant association ofMycobacterium aviumsubspeciesparatuberculosis(MAP) with T1D in adult Sardinian patients. To enforce this finding, we investigated the presence of antibodies against ZnT8 and proinsulin (PI) with respective homologous epitopes: MAP3865c133–141/ZnT8186–194, MAP3865c125–133/ZnT8178–186, MAP2404c70–85/PI46–61, and MAP1,4αgbp157–173/PI64–80, in 23 children at risk for T1D, formerly involved in the TRIGR study, and 22 healthy controls (HCs). Positivity to anti-MAP and homologous human peptides was detected in 48% of at-risk subjects compared to 5,85% HCs, preceding appearance of islet autoantibodies. Being MAP easily transmitted to humans with infected cow’s milk and detected in retail infant formulas, MAP epitopes could be present in extensively hydrolyzed formula and act as antigens stimulatingβ-cell autoimmunity.
  • Zinc and other metals deficiencies and risk of type 1 diabetes: An ecological study in the high risk Sardinia Island
    Paolo Valera, Patrizia Zavattari, Alessandro Sanna, Salvatore Pretti, Alberto Marcello, Carla Mannu, Clara Targhetta, Graziella Bruno, Marco Songini
    Plos One, 2015
    BACKGROUND Type 1 diabetes incidence presents a decreasing gradient in Europe from the Nordic countries to the Mediterranean ones. Exception to this gradient is represented by Sardinia, the second largest Mediterranean island whose population shows the highest incidence in Europe, after Finland. The genetic features of this population have created a fertile ground for the epidemic of the disease, however, as well as being strikingly high, the incidence rate has suddenly presented a continuous increase from the '50s, not explainable by accumulation of new genetic variants. Several environmental factors have been taken into account, possibly interacting with the genetic/epigenetic scenario, but there are no strong evidences to date. METHODS The present study investigated the hypothesis that geochemical elements could create permissive environmental conditions for autoimmune diabetes. An ecological analysis was performed to test possible correlations between the values of eight elements in stream sediments and type 1 diabetes incidence rate in Sardinia. RESULTS Analyses revealed negative associations between elements, such as Co, Cr, Cu, Mn, Ni, Zn, and type 1 diabetes incidence. CONCLUSIONS The results suggest a possible protective role of some elements against the onset of the disease.
  • Periodontal health in teenagers treated with removable aligners and fixed orthodontic appliances
    G.M. Abbate, M.P. Caria, P. Montanari, C. Mannu, G. Orrù, A. Caprioglio, L. Levrini
    Journal of Orofacial Orthopedics, 2015
  • More than 20 years of registration of type 1 diabetes in sardinian children: Temporal variations of incidence with age, period of diagnosis, and year of birth
    Graziella Bruno, Milena Maule, Annibale Biggeri, Alessia Ledda, Carla Mannu, Franco Merletti, Marco Songini, and
    Diabetes, 2013
    We analyzed Sardinian registry data to assess time trends in incidence rates (IRs) of type 1 diabetes during the period 1989–2009 (2,371 case subjects 0–14 years of age). Poisson regression models were used to estimate the effects of sex, age, period of diagnosis, and birth cohorts. IR was 44.8 cases/100,000 person-years (95% CI 43.1–46.7). The annual increase was 2.12% (1.45–2.80; test for linear trend, P < 0.001). For boys, the increasing trend was evident up to 5 years of age and for girls up to 8 years of age. Compared with the 1989–1994 birth cohort, the relative risk increased from 0.78 (0.61–1.10) in 1974–1979 to 1.62 (1.18–2.23) in 2004–2009. The increase over period was less striking, with a tendency to regress in more recent years. The best-fitting model for boys included age and a linear time trend, and for girls age and nonlinear effects of calendar period and birth cohort. In conclusion, incidence increased over time, and the increase tended to level off in more recent years by calendar period but not by birth cohort, with some evidence of a stronger increase among girls than boys. Should the increase be attributable to the effects of some perinatal environmental factor, this would mean that such a factor has started affecting females before males.