Desie Dwi Wisudanti

@fk.unej.ac.id

Department of Pharmacology, Faculty of Medicine, University of Jember
Department of Pharmacology, Faculty of Medicine, University of Jember, Jember, Indonesia

Desie Dwi Wisudanti


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https://researchid.co/wisudanti

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacology (medical), Medicine
6

Scopus Publications

132

Scholar Citations

7

Scholar h-index

3

Scholar i10-index

Scopus Publications

  • Subchronic Oral Exposure to Chlorpyrifos Decreases Butyrylcholinesterase in Wistar Rat
    Elly Nurus Sakinah, Supangat Supangat, Desie Dwi Wisudanti, Cholis Abrori, Arifa Mustika, Sony Wibsono, Nabil Athoillah
    Althea Medical Journal, 2024
    Background: Indonesia as an agricultural country has more than 33 million workers in the agriculture. Pesticides have an important role in agriculture because they function as powerful plant pest exterminators. However, its use is considered to cause various toxic effects, one of which is on the nervous system. This study aimed to evaluate the impact of pesticide exposure on cognitive impairment by assessing the butyrylcholinesterase biomarker in the blood of rats as experimental animals.Methods: This was a true experimental study conducted during September–November 2022 at the Pharmacology and Biochemistry Laboratory, Faculty of Medicine, University of Jember with a post-test only approach using Wistar rats which were divided into 1 control group and 4 treatment groups treated with chlorpyrifos 5 mg/kg orally. Serum butyrylcholinesterase enzyme levels were measured using the kinetic photometric method and then analyzed with a regression test in IBM SPSS® Statistics software. Results: The average value of butyrylcholinesterase was 920.23±145.27 (Control group); 904.48±91.6 (7 days after chlorpyrifos administration); 889.81±95.2 (14 days after chlorpyrifos administration); 457.84±69.5 (28 days after chlorpyrifos administration); 575.82±194.25 (56 days after chlorpyrifos administration). The results of the One-Way ANOVA test showed significant differences between groups as indicated by a significance test of 0.024 (p <0.05).Conclusions: There is a relationship between the duration of exposure to chlorpyrifos and butyrylcholinesterase levels in Wistar rats. This fact shows that the longer an organism is exposed to low doses of chlorpyrifos pesticides, the higher the level of neurological system toxicity that occurs in that organism.
  • Gel of Monascus purpureus JmbA rice accelerate wound healing in diabetic rats
    Ika Rahmawati SUTEJO, Desie Dwi WISUDANTI, Alfira Khoirun NISA, Alya Febriana GOESTIEN, Latiefah Noer WIDIASTUTI, Novik NURHIDAYAT, Sugiyanta SUGIYANTA, Ali SANTOSA
    Journal of Research in Pharmacy, 2024
    The most frequent complication of diabetes mellitus (DM) is diabetic ulcer, with a prevalence of 15-20% and an amputation rate of 30%. There is no effective and easy-to-apply treatment for acute-phase open wounds of patients with DM to prevent their development into ulcers. Monascus purpureus jmbA Rice (MJR) from Jember is superior to similar products from other regions in Indonesia because it has the highest monacolin content with an antioxidant effect. The study aimed to prove the effectiveness of MJR gel in accelerating the healing of acute wounds of diabetic rats. This true experimental laboratory research was a posttest-only control group design. We used Rattus norvegicus Wistar rats, 3-4 months old, weighing 200-300 grams. The 36 rats were divided into four treatment groups. The control group was given a gel of MJR 0%. The positive control group was given the antibiotic and placenta extract gel combination, and treatment groups T1 and T2 were given gel MJR40% and MJR80%. Excision wounds were made as deep as the subcutaneous layer on the back of the hyperglycemic rat. Four rats were terminated from each group on days 4, 11, and 18, and skin tissue was taken to observe the percentage of wound area shrinkage, epithelial thickness, and fibroblast count and analyze the levels of hydroxyproline and MDA. The MJR80% group had the highest percentage of wound area shrinkage, epithelial thickness, and fibroblast count compared to other groups. MDA levels decreased with increasing days in all treatment groups. Hydroxyproline levels increased on days 4 and 11, then decreased on day 18 in all treatment groups. We conclude that the 80% MJR group revealed the best acute diabetic wound healing. It was not statistically different from the combination of antibiotic and placenta extract gel treatment group.
  • The effect of chlorpyrifos oral exposure on the histomorphometric and kidney function in Wistar rat
    Elly Nurus Sakinah, Desie Dwi Wisudanti, Cholis Abrori, Supangat Supangat, Laily Rahmah Ramadhani, Indis Suyanto Putri, Galang Cahyo Pamungkas, Muhammad Hanif Arrobani, Risa Rahmadina, Pandego Wahyu Dirgantara
    Indian Journal of Pharmacology, 2024
    BACKGROUND: Chlorpyrifos belongs to a broad-spectrum organophosphate insecticide that has high toxicity, is metabolized in the liver by the oxidation reaction, and can inhibit acetylcholinesterase activity. Acetylcholinesterase inhibition generates the reactive oxygen species and induces oxidative stress, which ultimately results in cellular damage like in the kidney. Examining blood urea nitrogen (BUN) levels, creatinine, and kidney histopathology is an appropriate indicator to assess the toxicity of chlorpyrifos to the degree of damage to cells and kidney tissue. MATERIALS AND METHODS: This research used to determine the effect of duration of exposure to chlorpyrifos and dose–response relationships is important for early detection of the effects of chlorpyrifos toxicity on health. The research study was a true experimental (completely randomized design) consisting of 30 subjects divided into 5 groups. Controlled Group (K1) given 1 mg/kg BW Tween 20 and NaCl 0, 9% until the 56th day. The chlorpyrifos exposed group (P1, P2, P3, and P4) was given chlorpyrifos 5 mg/kg BW for 7, 14, 28, and 56 days. After the treatment, BUN and creatinine levels were measured, and microscopic changes in the kidney were analyzed. The results of BUN, creatinine, and kidney histopathologic were analyzed using the analysis of variance statistical test. RESULTS: The data result showed that compared to the control group, there were significant increases of BUN and creatinine (P = 0.013 and P = 0.003). Histopathological examinations of kidney glomerulus diameter were also smaller compared to the control group (P = 0.00). All the data measurement indicates significant differences compared to the control group. CONCLUSIONS: We concluded that sub-chronic oral exposure to chlorpyrifos at low doses can damage the kidneys and cause kidney failure.
  • Effectiveness of Edamame (Glycine max L. Merril) Membrane in Accelerating The Wound Healing Process of Deep-Partial Thickness Burn
    Ika SUTEJO
    Hacettepe University Journal of the Faculty of Pharmacy, 2023
    The gold standard for deep-partial thickness burns is early excision and skin graft; however, many hospitals in Indonesia still use conventional treatment due to the high cost of surgery and the requirement of qualified medical professionals. This research aimed to study the effectiveness of edamame (Glycine max. L Merill) membrane as therapeutic innovation in deep-partial thickness burns. Forty-eight male Wistar rats with deep-partial thickness burns were assigned randomly to four groups, including control and treatment (silver sulfadiazine, the membrane with 40% and 60% edamame extract). Measuring wound healing parameters such as macroscopic evaluation, histopathologic, and hydroxyproline was examined on days 4, 10, and 16. Treatment groups of membrane edamame significantly improved wound healing than the control group. Macroscopically, histopathological findings and hydroxyproline assay confirmed the efficacy of the edamame membrane at 60%, which provided the best healing results. This study showed that edamame membrane is effective as deep-partial thickness burns wound dressing.
  • Hepatoprotective effects of soy flour (Glycine max (l.) merr.) supplementation in diazinon-treated wistar rats
    Tropical Journal of Natural Product Research, 2021
    a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal.
  • Kefir stimulates anti-inflammatory response in TB-AFB (+) patients
    Tri Yudani Mardining Raras, Hetti Rusmini, Desie Dwi Wisudanti, Iin Noor Chozin
    Pakistan Journal of Nutrition, 2015
    Regular consumption of kefir promotes beneficial physiological and therapeutic effects including stimulation of immune response. In this study, we investigated the immunomodulatory effects of kefir on peripheral mononuclear cells (PBMCs) derived from patients diagnosed with pulmonary tuberculosis (TB). PBMCs were isolated, treated with different concentration of kefir (1/20, 1/50, 1/100 and 1/200) and cultured for 4 days. The proportion of CD4+ and CD8+ cells was analyzed by flow cytometry and the production of Th1 cytokines IL-2 and IFN-γ and Th2 cytokines IL-4 and IL-10 was determined by ELISA. The results indicate that kefir slightly stimulated CD4+ as well as CD8+, but the effect was insignificant. Low doses of kefir significantly induced the secretion of IL-10 but not IL-2, IL-4, or IFN-γ. We conclude that kefir in a low concentration stimulates Th2 rather than Th1-type immune response and therefore works as an immunosuppressant for early diagnosed TB patients.

RECENT SCHOLAR PUBLICATIONS

  • Alteration of Metformin Pharmacokinetic Profile in Rats Exposed to a Low Dose of Chlorpyrifos Insecticide
    DD Wisudanti, C Abrori, EN Sakinah, C Komariah, S Supangat
    Biology, Medicine, & Natural Product Chemistry 15 (1), 15-21 , 2026
    2026
  • The Impact of Comorbidities on Drug-Resistant Tuberculosis Treatment Success at Dr. Soebandi Hospital Jember 2018-2022
    AMR Muhammad Rafi’uddin Hafa, Diana Chusna Mufida, Desie Dwi Wisudanti
    Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia … , 2026
    2026
  • The Relationship Between Hypertension and Mortality in COVID-19 Patients at Soedirman MS Wonogiri Hospital
    DS Anisa, DD Wisudanti, P Wulandari
    WMJ (Warmadewa Medical Journal) 10 (2), 80-87 , 2025
    2025
  • Associated Risk Factors for Depression in MDR-TB Patients Receiving Cycloserine Therapy at dr. Soebandi Regional Hospital
    N Maulidiyah, DD Wisudanti, DA Rachmawati, C Komariah, AM Raharjo
    Jurnal Respirologi Indonesia 45 (3), 184-193 , 2025
    2025
  • Computational Insights into Leucaena leucocephala Extract Shampoo as a Malassezia furfur Anti-Dandruff Agent
    MF Hibatulloh, T Nafisa, MS Afnan, MP Andriani, CAL Widanto, ...
    Journal of Agromedicine and Medical Sciences 11 (2), 64-70 , 2025
    2025
  • Effects of Long Exposure to Low Dose of Chlorpyrifos on Total Cholesterol Levels in Wistar Rats
    DD Wisudanti, MZA Barus, EN Sakinah, A Purwandhono
    eJournal Kedokteran Indonesia 12 (3), 288 , 2025
    2025
  • Effect of Low-Dose Chlorpyrifos on Hepatocyte Necrosis and Serum Albumin Levels in Wistar Rats
    C Abrori, SA Dwisaraswati, SS Wahyudi, NS Rumastika
    2025
    Citations: 1
  • The Correlation Between Organophosphate Pesticide Exposure and Incidence of Prostate Cancer: A Systematic Review
    AMN Octavia, DD Wisudanti, P Wulandari
    Indonesian Journal of Cancer 18 (4), 501-506 , 2024
    2024
    Citations: 1
  • Long-Term Effects of Low-Dose Chlorpyrifos Exposure on Serum Albumin Levels in Male Wistar Rats
    DD Wisudanti, N Hidayat, MA Jauhani
    Journal of Biomedicine and Translational Research 10 (3), 120-125 , 2024
    2024
    Citations: 2
  • Gel of Monascus purpureus JmbA rice accelerate wound healing in diabetic rats
    I Sutejo, DD Wisudanti, AK Nisa, AF Goestien, LN Widiastuti, ...
    Journal of Research in Pharmacy 28 (3), 699-707 , 2024
    2024
    Citations: 2
  • The effect of chlorpyrifos oral exposure on the histomorphometric and kidney function in Wistar rat
    EN Sakinah, DD Wisudanti, C Abrori, S Supangat, LR Ramadhani, ...
    Indian journal of pharmacology 56 (3), 186-190 , 2024
    2024
    Citations: 7
  • Subchronic Oral Exposure to Chlorpyrifos Decreases Butyrylcholinesterase in Wistar Rat
    EN Sakinah, S Supangat, DD Wisudanti, C Abrori, A Mustika, S Wibsono, ...
    Althea Medical Journal 11 (1), 20-25 , 2024
    2024
  • Hubungan pengetahuan terhadap sikap dan perilaku penggunaan antibiotik pada mahasiswa medis dan kesehatan Universitas Jember
    DD Wisudanti, WH Setyaningrum, E Efensi
    Jember Medical Journal 2 (2), 72-82 , 2023
    2023
    Citations: 7
  • Comparison of the Effectiveness between Oral NSAIDs and Dextrose Prolotherapy in Knee Osteoarthritis
    S Sugiyanta, WS Dwicahyandari, E Efendi, DD Wisudanti
    Global Medical & Health Communication (GMHC) 11 (1), 61-66 , 2023
    2023
  • Effectiveness of Vitamin C Administration on Outcome in COVID-19 Patients: A Systematic Review and Meta-Analysis
    DD Wisudanti, NLNS Kusumasari, A Handoko, C Abrori, AM Raharjo
    Jurnal Respirologi Indonesia 43 (2), 121-130 , 2023
    2023
    Citations: 1
  • Subchronic exposure to Chlorpyrifos, Carbofuran, and Cypermethrin increase sciatic nerve damage and degeneration in adolescent rats
    DDW Muhammad Ihwan Narwanto, Muhammad Haikal Supriyadi
    Qanun Medika 7 (1), 69-78 , 2023
    2023
  • Effectiveness of Edamame (Glycine max L. Merril) Membrane in Accelerating The Wound Healing Process of Deep-Partial Thickness Burn
    I Sutejo
    Hacettepe University Journal of the Faculty of Pharmacy 43 (2), 120-127 , 2023
    2023
  • Patterns Of Drug Use In Patients With Knee Osteoarthritis At The Bina Sehat Jember Hospital
    FP Andraputra, DD Wisudanti, MA Shodikin
    Saintika Medika 18 (2), 145-158 , 2022
    2022
  • The Correlation between Fatigue and Quality of Life on Knee Osteoarthritis Patient at RSD dr. Soebandi Jember
    Y Hermansyah, MP Ridlo, DD Wisudanti
    Journal of Agromedicine and Medical Sciences 8 (3), 170-174 , 2022
    2022
    Citations: 1
  • Pili Protein 65.5 kDa of Klebsiella pneumoniae Induced a Decrease in IL-10 in Mice
    D Agustina, ML Wati, DD Wisudanti, MA Shodikin, DC Mufida, E Suswati
    Majalah Kedokteran Bandung 54 (3), 143-147 , 2022
    2022
    Citations: 1

MOST CITED SCHOLAR PUBLICATIONS

  • Korelasi Jumlah Trombosit dan Kadar Hematokrit terhadap tingkat Keparahan Pasien Demam Berdarah Dengue di RSD dr Soebandi Jember
    SN Tirtadevi, R Riyanti, DD Wisudanti, SN Tirtadevi, R Riyanti, ...
    Sciences 7 (3), 156-161 , 2021
    2021
    Citations: 25
  • Diazinon toxicity to kidney and liver of Wistar male rats in terms of biochemical and histopathological parameters
    DD Wisudanti, F Herdiana, TS Qodar
    Journal of Agromedicine and Medical Sciences 5 (2), 112-117 , 2019
    2019
    Citations: 19
  • The effect of kefir on the immune response of healthy volunteers in vitro
    DD Wisudanti
    Journal of Agromedicine and Medical Sciences 3 (2), 28-34 , 2017
    2017
    Citations: 11
  • The Analgesic Effectiveness Test of Cocoa Husk (Theobroma cacao L.) Extract to Licking Time of Mice Induced by Formalin
    YL Sari, DD Wisudanti, MA Shodikin
    Journal of Agromedicine and Medical Sciences 4 (2), 83-89 , 2018
    2018
    Citations: 8
  • Kefir stimulates anti-inflammatory response in TB-AFB (+) patients
    TYM Raras, H Rusmini, DD Wisudanti, IN Chozin
    Pakistan Journal of Nutrition 14 (6), 330-334 , 2015
    2015
    Citations: 8
  • The effect of chlorpyrifos oral exposure on the histomorphometric and kidney function in Wistar rat
    EN Sakinah, DD Wisudanti, C Abrori, S Supangat, LR Ramadhani, ...
    Indian journal of pharmacology 56 (3), 186-190 , 2024
    2024
    Citations: 7
  • Hubungan pengetahuan terhadap sikap dan perilaku penggunaan antibiotik pada mahasiswa medis dan kesehatan Universitas Jember
    DD Wisudanti, WH Setyaningrum, E Efensi
    Jember Medical Journal 2 (2), 72-82 , 2023
    2023
    Citations: 7
  • Assessments of quality of life in burn patients after hospital treatment in Jember
    AM Utami, U Elfiah, DD Wisudanti
    JKKI: Jurnal Kedokteran dan Kesehatan Indonesia, 157-164 , 2020
    2020
    Citations: 7
  • Aktivitas Ekstrak Metanol Bawang Putih (Allium sativum) sebagai Penghambat Pembentukan Biofilm pada Pseudomonas aeruginosa (The Activity of Methanolic Extract of Garlic (Allium …
    RPL Wangi, E Suswati, DD Wisudanti
    Pustaka Kesehatan 5 (3), 537-543 , 2017
    2017
    Citations: 7
  • Effect of Soyflour (Glycine max L.) Hepatoprotector Activity on Liver MDA Level in Male Wistar Rat Induced by Diazinon
    SA Himah, DD Wisudanti, H Fatmawati
    Journal of Agromedicine and Medical Sciences 4 (1), 1-6 , 2018
    2018
    Citations: 6
  • Literature Review: Therapeutic Application of Geraniin From Rambutan (Nephelium lappaceum) Peel Extract as Antihyperglycemic Through Its Antioxidant Activity in Type 2 Diabetes …
    DD Wisudanti
    NurseLine Journal 1 (1), 120-138 , 2016
    2016
    Citations: 6
  • Hubungan antara Kadar Feritin dengan Malondialdehyde pada Pasien Talasemia β Mayor di RSD dr. Soebandi Jember
    TD Permatasari, R Riyanti, DD Wisudanti
    Pustaka Kesehatan 7 (1), 52 , 2020
    2020
    Citations: 5
  • Hepatoprotective Effects of Soy Flour (Glycine max (L.) Merr.) Supplementation in Diazinon-Treated Wistar Rats
    TH Desie Dwi Wisudanti, Rena Normasari
    Tropical Journal of Natural Product Research 5 (2), 233-237 , 2021
    2021
    Citations: 3
  • Analysis of Varicose Vein in Lower Extremities Risk Factors on Woman Laborers of Tobacco Picker at Ajung District Jember Regency
    MF Akbar, ISW Astuti, DD Wisudanti
    Journal of Agromedicine and Medical Sciences 5 (1), 39-44 , 2019
    2019
    Citations: 3
  • Long-Term Effects of Low-Dose Chlorpyrifos Exposure on Serum Albumin Levels in Male Wistar Rats
    DD Wisudanti, N Hidayat, MA Jauhani
    Journal of Biomedicine and Translational Research 10 (3), 120-125 , 2024
    2024
    Citations: 2
  • Gel of Monascus purpureus JmbA rice accelerate wound healing in diabetic rats
    I Sutejo, DD Wisudanti, AK Nisa, AF Goestien, LN Widiastuti, ...
    Journal of Research in Pharmacy 28 (3), 699-707 , 2024
    2024
    Citations: 2
  • Effect of Low-Dose Chlorpyrifos on Hepatocyte Necrosis and Serum Albumin Levels in Wistar Rats
    C Abrori, SA Dwisaraswati, SS Wahyudi, NS Rumastika
    2025
    Citations: 1
  • The Correlation Between Organophosphate Pesticide Exposure and Incidence of Prostate Cancer: A Systematic Review
    AMN Octavia, DD Wisudanti, P Wulandari
    Indonesian Journal of Cancer 18 (4), 501-506 , 2024
    2024
    Citations: 1
  • Effectiveness of Vitamin C Administration on Outcome in COVID-19 Patients: A Systematic Review and Meta-Analysis
    DD Wisudanti, NLNS Kusumasari, A Handoko, C Abrori, AM Raharjo
    Jurnal Respirologi Indonesia 43 (2), 121-130 , 2023
    2023
    Citations: 1
  • The Correlation between Fatigue and Quality of Life on Knee Osteoarthritis Patient at RSD dr. Soebandi Jember
    Y Hermansyah, MP Ridlo, DD Wisudanti
    Journal of Agromedicine and Medical Sciences 8 (3), 170-174 , 2022
    2022
    Citations: 1