Hadeer Muhammed Morsy

@hadermohamed98_pg@science.bsu.edu.eg

Faculty of science, Zoology Department
Beni-Suef University

Hadeer Muhammed Morsy


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https://researchid.co/hadeermuhammedmorsy

RESEARCH, TEACHING, or OTHER INTERESTS

Animal Science and Zoology, Molecular Biology, Cancer Research, Physiology
6

Scopus Publications

42

Scholar Citations

3

Scholar h-index

2

Scholar i10-index

Scopus Publications

  • The Role of MicroRNAs as Hepatocellular Carcinoma Biomarkers and Therapeutic Targets
    Hadeer M. Morsy, Mohamed Y. Zaky, Osama M. Ahmed
    Advances in Biochemistry in Health and Disease, 2026
  • Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
    Mohamed Y. Zaky, Hadeer M. Morsy, Adel Abdel-Moneim, Khairy M. A. Zoheir, Anthony Bragoli, Mostafa A. Abdel-Maksoud, Abdulaziz Alamri, Osama M. Ahmed
    Discover Oncology, 2025
    This investigation explored the chemopreventive effects of eugenol on diethylnitrosamine (DENA) and acetylaminofluorene (AAF)-induced hepatocellular carcinoma (HCC) in Wistar rats. To induce HCC, DENA was administered intraperitoneally once per week for two weeks at a concentration of 150 mg/kg body weight (b.w.), followed by oral AAF administration for 3 weeks, four times a week, at a dosage of 20 mg/kg b.w. After these three weeks, the rats were treated with eugenol every other day for 17 weeks at a dosage of 20 mg/kg b.w. In vitro, eugenol reduced cell viability (IC50 of 189.29 µg/mL) and inhibited cell migration in the HCC cell line HepG2. Moreover, eugenol treatment in DENA/AAF-induced rats significantly improved cancerous histopathological changes and reduced inflammatory cell infiltration in the liver. Eugenol treatment significantly reduced the activity levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), along with the levels of total bilirubin (TBIL), alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9), lipid peroxides (LPO), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β). Additionally, the expressions of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), interleukin-8, C-X-C Motif Chemokine Receptor 3 (CXCR3), B-cell lymphoma 2 (Bcl-2), IQ Motif Containing GTPase Activating Protein 1 (IQGAP1), IQ Motif Containing GTPase Activating Protein 3 (IQGAP3), Harvey rat sarcoma viral oncogene homolog (HRAS), Kirsten rat sarcoma viral oncogene homolog (KRAS), and Ki-67 were downregulated following eugenol administration in DENA/AAF-induced HCC. Conversely, eugenol supplementation significantly enhanced glutathione (GSH) content, as well as the activities of glutathione peroxidase (GPx) and superoxide dismutase (SOD), and the levels of nuclear factor erythroid 2-related factor 2 (Nrf2). Furthermore, the expressions of tumor suppressor gene p53, Bcl-2-associated X protein (BAX), death receptor 4 (DR4), death receptor 5 (DR5), decoy receptor 1 (DcR1), programmed cell death 5 (PDCD5), and IQ Motif Containing GTPase Activating Protein 2 (IQGAP2) were markedly upregulated compared to the DENA/AAF-administered group. These findings indicate that the potent anticancer effects of eugenol are primarily driven by its ability to reduce oxidative stress, suppress inflammation, and inhibit cell proliferation while promoting apoptosis. This study underscores the potential of eugenol as a promising therapeutic agent for the prevention and management of HCC, offering a novel approach to HCC treatment.
  • Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals
    Hadeer M. Morsy, Mohamed Y. Zaky, Nour Y.S. Yassin, Ashraf Y.Z. Khalifa
    International Journal of Pharmaceutics, 2025
  • Phytochemicals as Protective Agents for Brain Aging
    Mohamed Y. Zaky, Hadeer M. Morsy, Osama M. Ahmed
    Neuroprotective Effects of Phytochemicals in Brain Ageing, 2024
  • The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action
    Hadeer M. Morsy, Osama M. Ahmed, Khairy M. A. Zoheir, Adel Abdel-Moneim
    Apoptosis, 2023
    This study was designed to assess the ameliorative effects of eugenol and to propose the possible mechanisms of action of eugenol in diethylnitrosamine (DENA)/acetylaminofluorene (AAF)-caused lung cancer in Wistar rats. To induce lung cancer, DENA at a dose of 150 mg/kg body weight (b.wt) for 2 weeks were intraperitoneally injected once each week and AAF was administered orally at a dose of 20 mg/kg b.wt. four times each week for the next 3 weeks. DENA/AAF-administered rats were orally supplemented with eugenol at a dose of 20 mg/kg b.wt administered once a day until 17 weeks starting from the 1st week of DENA administration. Lung histological lesions, including sheets of tumor cells, micropapillary adenocarcinoma, and apoptotic cells, resulting from the DENA/AAF dosage, were ameliorated by eugenol treatment. However, a significant drop in the levels of LPO in the lungs and a remarkable rise in GSH content and GPx and SOD activities were observed in DENA/AAF-administered rats treated with eugenol compared with those in DENA/AAF-administered controls. Moreover, in DENA/AAF-administered rats, eugenol supplementation significantly reduced TNF-α and IL-1β levels and mRNA expression levels of NF-κB, NF-κB p65, and MCP-1 but significantly elevated the level of Nrf2. Furthermore, the DENA/AAF-administered rats treated with eugenol exhibited a significant downregulation of Bcl-2 expression levels in addition to a significant upregulation in P53 and Bax expression levels. Otherwise, the administration of DENA/AAF elevated the protein expression level of Ki-67, and this elevation was reversed by eugenol treatment. In conclusion, eugenol has effective antioxidant, anti-inflammatory, proapoptotic, and antiproliferative properties against lung cancer. Graphical abstract
  • An overview of hepatocellular carcinoma stem cells and potential targeted therapies
    Mohamed Y. Zaky, Hadeer M. Morsy, Osama M. Ahmed
    Cancer Stem Cells and Signaling Pathways, 2023

RECENT SCHOLAR PUBLICATIONS

  • The Role of MicroRNAs as Hepatocellular Carcinoma Biomarkers and Therapeutic Targets
    HM Morsy, MY Zaky, OM Ahmed
    MicroRNAs: Role in Cancer Progression, Diagnostics and Therapy, 451-468 , 2026
    2026
  • Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
    MY Zaky, HM Morsy, A Abdel-Moneim, KMA Zoheir, A Bragoli, ...
    Discover Oncology 16 (1), 1080 , 2025
    2025
    Citations: 6
  • Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals
    HM Morsy, MY Zaky, NYS Yassin, AYZ Khalifa
    International Journal of Pharmaceutics 670, 125135 , 2025
    2025
    Citations: 21
  • Phytochemicals as Protective Agents for Brain Aging
    MY Zaky, HM Morsy, OM Ahmed
    Neuroprotective Effects of Phytochemicals in Brain Ageing, 1-16 , 2024
    2024
  • An overview of hepatocellular carcinoma stem cells and potential targeted therapies
    MY Zaky, HM Morsy, OM Ahmed
    Cancer Stem Cells and Signaling Pathways, 581-590 , 2024
    2024
    Citations: 2
  • The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action
    HM Morsy, OM Ahmed, KMA Zoheir, A Abdel-Moneim
    Apoptosis 28 (7), 1184-1197 , 2023
    2023
    Citations: 13

MOST CITED SCHOLAR PUBLICATIONS

  • Nanoparticle-based flavonoid therapeutics: Pioneering biomedical applications in antioxidants, cancer treatment, cardiovascular health, neuroprotection, and cosmeceuticals
    HM Morsy, MY Zaky, NYS Yassin, AYZ Khalifa
    International Journal of Pharmaceutics 670, 125135 , 2025
    2025
    Citations: 21
  • The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: insight on the mechanisms of action
    HM Morsy, OM Ahmed, KMA Zoheir, A Abdel-Moneim
    Apoptosis 28 (7), 1184-1197 , 2023
    2023
    Citations: 13
  • Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
    MY Zaky, HM Morsy, A Abdel-Moneim, KMA Zoheir, A Bragoli, ...
    Discover Oncology 16 (1), 1080 , 2025
    2025
    Citations: 6
  • An overview of hepatocellular carcinoma stem cells and potential targeted therapies
    MY Zaky, HM Morsy, OM Ahmed
    Cancer Stem Cells and Signaling Pathways, 581-590 , 2024
    2024
    Citations: 2
  • The Role of MicroRNAs as Hepatocellular Carcinoma Biomarkers and Therapeutic Targets
    HM Morsy, MY Zaky, OM Ahmed
    MicroRNAs: Role in Cancer Progression, Diagnostics and Therapy, 451-468 , 2026
    2026
  • Phytochemicals as Protective Agents for Brain Aging
    MY Zaky, HM Morsy, OM Ahmed
    Neuroprotective Effects of Phytochemicals in Brain Ageing, 1-16 , 2024
    2024