Negar Firouzabadi

Scopus Publications

Evaluation of the circulating levels of IL-33 in patients with osteoarthritis: role of rs1929992 variants
Nahid Alimoradi, Fatemeh Jahankhah, Habibollah Jokardarzi, Mohammad Tahami, Negar Firouzabadi
Cytokine, 2025
BACKGROUND: Osteoarthritis (OA) is among the common chronic health conditions which impacts many aspects of an individual's life from physical function to mental health. Inflammation, in the joint as well as system inflammation is among the many mechanisms hypothesized to be involved in OA. IL-33 which belongs to the IL-1 family, is considered as an alarmin in OA. IL-33 binds to a group of receptors to stimulate signaling among which is the ST2L receptor that induced the activation of NFƙb, thus, working as a booster of the inflammatory cascade. Many polymorphisms have been identified on the IL-33 gene which are assumed to be associated with inflammatory diseases. METHODS: In the current double-blind placebo-controlled clinical trial study, patients diagnosed with knee OA were randomly divided into two groups: one group received metformin and the other received a placebo for 16 consecutive weeks (starting at 0.5 g/day, increasing to 1 g/day at week two, and increasing to 1.5 g/day for the remaining 14 weeks). Besides the evaluation of the clinical response to metformin using the Knee Injury and OA Outcome Score (KOOS) questionnaire, the serum levels of IL-33 was measured using enzyme-linked immunosorbent assay (ELISA) kits before (time 0) and after treatment (month 4). Genetic polymorphism of rs1929992 was assessed using in extracted DNAs using PCR-RFLP method. RESULTS: Serum levels of IL-33 were significantly higher in OA patients compered to healthy individuals (P<0.001). Mutant allele (G allele) of the rs1929992 was significantly associated with OA (P=0.028; OR=1.9; 95%CI: 1.02-3.6). AG+GG genotypes were also associated with OA (P=0.004; OR=3.8, 95%CI: 1.5-9.5). Metformin did not affect IL-33 levels (P>0.05). Variants of rs1929992 were not associated with response to metformin (P>0.05). CONCLUSION: Our findings support the role of polymorphisms of IL-33 gene and circulating levels of IL-33 in OA. Drugs targeting IL-33 signaling pathway may propose beneficial effects in OA.
Investigation on the association between Osteopontin and Apolipoprotein E gene polymorphisms and vancomycin-induced acute kidney injury: A pharmacokinetic/pharmacogenetic study in critically ill patients
Negar Firouzabadi, Dorsa Karbasi, Parisa Ghasemiyeh, Farzaneh Sadeghi, Nahid Alimoradi, Maryam Kavousi, Soliman Mohammadi-Samani
Gene, 2025
Binding interaction of food preservatives with glycosylated DNA: In vitro assessment and computational studies
Leila Emami, Somayeh Hoshyar, Samaneh Bina, Fateme Zare, Pegah Mardaneh, Marziyeh Haghshenas, Alireza Poustforoosh, Negar Firouzabadi, Marzieh Rashedinia
Journal of Molecular Structure, 2025
Comparison between Inhibition of CatSper and KSper Channels with NNC 55-0396 and Quinidine on Human Sperm Function
Ali Zarei, Sara Keshtgar, M Haghani, Negar Firouzabadi, Mohammad Hossein Nasr‐Esfahani
Iranian Journal of Medical Sciences, 2025
Background: ) and membrane potential. Our study aims to investigate and compare the contributions of these channels in capacitated sperm function. Results: in live spermatozoa (P=0.05), and induced the acrosomal reaction (P=0.012). Conclusion: can inhibit sperm motility and increase mortality rate. It seems that the function of KSper is as vital as CatSper in human sperm physiology.
Metformin Exhibits Anti-Inflammatory Effects by Regulating microRNA-451/CXCL16 and B Cell Leukemia/Lymphoma 2 in Patients With Osteoarthritis
Nahid Alimoradi, Amin Ramezani, Mohammad Tahami, Negar Firouzabadi
Acr Open Rheumatology, 2025
ObjectiveOsteoarthritis (OA) is the most common cause of chronic disability in joints among older individuals. The primary goal of OA treatment is pain relief to improve the quality of life. Inflammation and aging are involved in the pathogenesis of pain in OA. In this study, we evaluated the ability of metformin to regulate microRNAs, such as miR‐451 and miR‐15b, and their target proteins, CXCL16 and B cell leukemia/lymphoma 2 (BCL‐2), involved in inflammation and apoptosis.MethodsIn this double‐blind placebo‐controlled clinical trial, patients were randomly divided into two groups: one receiving metformin and the other receiving a placebo for four months (starting at 0.5 g/day for the first week, increasing to 1 g/day for the second week, and increasing to 1.5 g/day for the remaining period). In addition to evaluating the clinical response using the Knee Injury and Osteoarthritis Outcome Score questionnaire, miR‐451 and miR‐15b expression levels were detected using real‐time polymerase chain reaction. The serum levels of CXCL16 and BCL‐2 were evaluated using enzyme‐linked immunosorbent assay kits before (time zero) and after treatment (month four).ResultsMetformin increased miR‐451 expression levels simultaneously with pain reduction, whereas miR‐15b expression did not change significantly after four months of treatment. Also, metformin decreased the serum levels of BCL‐2 and CXCL16 in patients with OA.ConclusionThe effects of metformin in reducing pain can be attributed to many factors, including its anti‐inflammatory and antiaging effects. Our findings suggest that metformin may reduce pain and inflammation in patients with OA through the regulation of miR‐451/CXCL16 and BCL‐2.
Smart nanogels as promising platform for delivery of drug, gene, and vaccine; therapeutic applications and active targeting mechanism
Fatemeh Farjadian, Soroush Mirkiani, Parisa Ghasemiyeh, Hadieh Rahbar Kafshboran, Sanaz Mehdi-Alamdarlou, Amin Raeisi, Reza Esfandiarinejad, Soroush Soleymani, Ghazal Goshtasbi, Negar Firouzabadi, Soliman Mohammadi-Samani, Mohammad Hossein Morowvat, Mohammad Doroudian
European Polymer Journal, 2024
Modulation of ACE2/Ang1-7/Mas and ACE/AngII/AT1 axes affects anticancer properties of sertraline in MCF-7 breast cancer cells
Reihaneh Fatehi, Mohammad Nouraei, Morteza Panahiyan, Marzieh Rashedinia, Negar Firouzabadi
Biochemistry and Biophysics Reports, 2024
The renin-angiotensin system (RAS) is best known for playing a major role in maintaining the physiology of the cardiovascular system. Dysregulation of the RAS pathway has been proposed as a link to some malignancies and contributes to cancer metastasis. Breast cancer is considered as one of the leading causes of cancer death in women and its prevention remains yet a challenge. Elements of RAS are expressed in both normal breast tissue and cancerous cells, signifying the essential role of RAS in breast cancer pathology. Sertraline, a widely used antidepressant, has shown anti-proliferative properties on a variety of malignancies. This study aimed to investigate the effect of sertraline and its combination with agonists and antagonists of RAS (A779, Ang 1-7 and losartan) on viability of MCF-7 cells along with their effect on apoptosis and distribution of cell cycle. Our results indicated that sertraline, losartan and Ang 1-7 significantly decreased cell viability, induced apoptosis and cell cycle arrest. A779 blunted the effect of sertraline on cell viability, ROS generation and cell cycle arrest. Combination treatment of sertraline with losartan as well as Ang 1-7 caused a remarkable decline in cell viability. In conclusion, results of the present study support the anti-cancer properties of sertraline, losartan and Ang 1-7 via induction of apoptosis and cell cycle arrest.
Signaling pathways and genetics of brain Renin angiotensin system in psychiatric disorders: State of the art
Roya Barak, Ghazal Goshtasbi, Reihaneh Fatehi, Negar Firouzabadi
Pharmacology Biochemistry and Behavior, 2024
The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies
Bahareh Hassani, Zeinab Attar, Negar Firouzabadi
Cancer Cell International, 2023
The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS signaling enhances cell proliferation in malignancy directly and indirectly by affecting tumor cells and modulating angiogenesis. Cancer development may be influenced by the balance between the ACE/Ang II/AT1R and the ACE2/Ang 1–7/Mas receptor pathways. The interactions between Ang II/AT1R and Ang I/AT2R as well as Ang1-7/Mas and alamandine/MrgD receptors in the RAAS pathway can significantly impact the development of cancer. Ang I/AT2R, Ang1-7/Mas, and alamandine/MrgD interactions can have anticancer effects while Ang II/AT1R interactions can be involved in the development of cancer. Evidence suggests that inhibitors of the RAAS, which are conventionally used to treat cardiovascular diseases, may be beneficial in cancer therapies.Herein, we aim to provide a thorough description of the elements of RAAS and their molecular play in cancer. Alongside this, the role of RAAS components in sex-dependent cancers as well as GI cancers will be discussed with the hope of enlightening new venues for adjuvant cancer treatment. Graphical abstract
Impact of vitamin D receptor gene polymorphisms (TaqI and BsmI) on the incidence and severity of coronary artery disease: a report from southern Iran
Boshra Akhlaghi, Negar Firouzabadi, Farzaneh Foroughinia, Marzieh Nikparvar, Pouyan Dehghani
BMC Cardiovascular Disorders, 2023
Background The association of vitamin D level and vitamin D receptor (VDR) gene polymorphisms with the prevalence of coronary artery disease (CAD) has been evaluated in various studies; however, the reported results were inconsistent. Hence, we aimed to investigate the impact of two VDR gene polymorphisms, TaqI (rs731236) and BsmI (rs1544410), on the incidence and severity of CAD in Iranian population. Methods Blood samples were collected from 118 CAD patients underwent elective percutaneous coronary intervention (PCI) and 52 control subjects. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed for genotyping. SYTNAX score (SS) was calculated as a grading tool for complexity of CAD by an interventional cardiologist. Results TaqI polymorphism of VDR was not associated with the incidence of CAD. A significant difference was observed between CAD patients and controls regarding BsmI polymorphism of VDR (p < 0.001). GA and AA genotypes was significantly associated with a decreased risk of CAD (p = 0.01, p-adjusted = 0.01 and p < 0.001, p-adjusted = 0.001 respectively). A allele of BsmI polymorphism was shown to have a protective effect against CAD (p < 0.001, p-adjusted = 0.002). No association was found between TaqI and BsmI polymorphisms of VDR and SS as a measure of CAD severity. Conclusion Association of BsmI genotypes with the incidence of CAD revealed that the genetic variation of VDR might play a role in the pathogenesis of CAD.
Polymorphism of glucocorticoid receptor gene (rs41423247) in functional seizures (psychogenic nonepileptic seizures/attacks)
Negar Firouzabadi, Ali A. Asadi‐Pooya, Nahid Alimoradi, Leila Simani, Marjan Asadollahi
Epilepsia Open, 2023
Metformin attenuates symptoms of osteoarthritis: role of genetic diversity of Bcl2 and CXCL16 in OA
Nahid Alimoradi, Mohammad Tahami, Negar Firouzabadi, Elham Haem, Amin Ramezani
Arthritis Research and Therapy, 2023
Combination of metformin and gallic acid induces autophagy and apoptosis in human breast cancer cells
Marziyeh Haghshenas, Negar Firouzabadi, Amin Reza Akbarizadeh, Marzieh Rashedinia
Research in Pharmaceutical Sciences, 2023
FKBP5 blockade may provide a new horizon for the treatment of stress-associated disorders: An in-silico study
Ali A. Asadi‐Pooya, Mahdi Malekpour, Bardia Zamiri, Mohammad Kashkooli, Negar Firouzabadi
Epilepsia Open, 2023
Potential role of FKBP5 single-nucleotide polymorphisms in functional seizures
Ali A. Asadi‐Pooya, Leila Simani, Marjan Asadollahi, Fatemeh Sadat Rashidi, Ehsan Ahmadipour, Afagh Alavi, Mehrdad Roozbeh, Nayyereh Akbari, Negar Firouzabadi
Epilepsia Open, 2023
Update on the effectiveness of COVID-19 vaccines on different variants of SARS-CoV-2
Negar Firouzabadi, Parisa Ghasemiyeh, Fatemeh Moradishooli, Soliman Mohammadi-Samani
International Immunopharmacology, 2023
Metformin enhances anti-cancer properties of resveratrol in MCF-7 breast cancer cells via induction of apoptosis, autophagy and alteration in cell cycle distribution
Reihaneh Fatehi, Marzieh Rashedinia, Amin Reza Akbarizadeh, Mozhdeh zamani, Negar Firouzabadi
Biochemical and Biophysical Research Communications, 2023
The effect of size, morphology and surface properties of mesoporous silica nanoparticles on pharmacokinetic aspects and potential toxicity concerns
Uranous Niroumand, Negar Firouzabadi, Ghazal Goshtasbi, Bahareh Hassani, Parisa Ghasemiyeh, Soliman Mohammadi-Samani
Frontiers in Materials, 2023
SNPs of ACE1 (rs4343) and ACE2 (rs2285666) genes are linked to SARS-CoV-2 infection but not with the severity of disease
Nahid Alimoradi, Moein Sharqi, Dena Firouzabadi, Mohammad Moein Sadeghi, Mohammad Iman Moezzi, Negar Firouzabadi
Virology Journal, 2022
Interleukin-33 and Soluble ST2 as Potential Biomarkers of Cancer in Opium Users: A Nested Case-Control Study
N. Firouzabadi, Kimia Javdani, A. Dehshahri
Iranian Journal of Medical Sciences, 2022
Impact of ACE2 genetic variant on antidepressant efficacy of SSRIs
Negar Firouzabadi, Parisa Farshadfar, Maral Haghnegahdar, Ali Alavi-Shoushtari, Vahid Ghanbarinejad
Acta Neuropsychiatrica, 2022
Anticancer properties of vincristine is modulated by microRNAs in acute lymphoblastic leukemia Nalm6 cell line
Elham Shirazi-Tehrani, Asma Vafadar, Majid Keshavarzi, Negar Firouzabadi
Anti Cancer Drugs, 2022
Pharmacological Approaches to Decelerate Aging: A Promising Path
Bahareh Hassani, Ghazal Goshtasbi, Shirin Nooraddini, Negar Firouzabadi
Oxidative Medicine and Cellular Longevity, 2022
ncRNAs and polyphenols: new therapeutic strategies for hypertension
Elham Shirazi-Tehrani, Alireza Chamasemani, Negar Firouzabadi, Marzieh Mousaei
RNA Biology, 2022
How metformin affects various malignancies by means of microRNAs: a brief review
Nahid Alimoradi, Negar Firouzabadi, Reihaneh Fatehi
Cancer Cell International, 2021
A brief ICU residents’ guide: Pharmacotherapy, pharmacokinetic aspects and dose adjustments in critically ill adult patients admitted to ICU
Parisa Ghasemiyeh, Soliman Mohammadi-Samani, Negar Firouzabadi, Afsaneh Vazin, Farid Zand
Trends in Anaesthesia and Critical Care, 2021
Association of human platelet alloantigens encoding gene polymorphisms with the risk of Coronary artery disease in Iranian patients
Farideh Malakootikhah, Hossein Naghavi, Negar Firouzabadi, Mohsen Maadani, Massoumeh Shafiei, Nader Tajik
BMC Cardiovascular Disorders, 2021
Drug-based therapeutic strategies for COVID-19-infected patients and their challenges
Khatereh Zarkesh, Elaheh Entezar-Almahdi, Parisa Ghasemiyeh, Mohsen Akbarian, Marzieh Bahmani, Shahrzad Roudaki, Rahil Fazlinejad, Soliman Mohammadi-Samani, Negar Firouzabadi, Majid Hosseini, Fatemeh Farjadian
Future Microbiology, 2021
A focused review on technologies, mechanisms, safety, and efficacy of available COVID-19 vaccines
Parisa Ghasemiyeh, Soliman Mohammadi-Samani, Negar Firouzabadi, Ali Dehshahri, Afsaneh Vazin
International Immunopharmacology, 2021
Pharmacogenetic-based management of depression: Role of traditional Persian medicine
Atefeh Jalali, Negar Firouzabadi, Mohammad M. Zarshenas
Phytotherapy Research, 2021
Metformin and insulin-resistant related diseases: Emphasis on the role of microRNAs
Nahid Alimoradi, Negar Firouzabadi, Reihaneh Fatehi
Biomedicine and Pharmacotherapy, 2021
Effect of escitalopram on an acetic acid-induced ulcerative colitis model
Negar Firouzabadi, Nahid Alimoradi, Mohammad Najafizadeh, Parvaneh Najafizadeh
Clinical and Experimental Pharmacology and Physiology, 2021
A longitudinal item response model for Aberrant Behavior Checklist (ABC) data from children with autism
Elham Haem, Marziyeh Doostfatemeh, Negar Firouzabadi, Nima Ghazanfari, Mats O. Karlsson
Journal of Pharmacokinetics and Pharmacodynamics, 2020
Biomarkers of IL-33 and SST2 and lack of association with carvedilol therapy in heart failure
Negar Firouzabadi, Maryam Dashti, Ali Dehshahri, Ehsan Bahramali
Clinical Pharmacology Advances and Applications, 2020
Orexin/hypocretin type 2 receptor (HCRTR2) gene as a candidate gene in sertraline-associated insomnia in depressed patients
Negar Firouzabadi, Niloofar Navabzadeh, Ebrahim Moghimi-Sarani, Maral Haghnegahdar
Neuropsychiatric Disease and Treatment, 2020
Overexpression of adiponectin receptors in opium users with and without cancer
Negar Firouzabadi, Maral Haghnegahdar, Bahman Khalvati, Ali Dehshahri, Ehsan Bahramali
Clinical Pharmacology Advances and Applications, 2020
Carvedilol alters circulating mir-1 and mir-214 in heart failure
Elham Shirazi-Tehrani, Negar Firouzabadi, Gholamhossein Tamaddon, Ehsan Bahramali, Asma Vafadar
Pharmacogenomics and Personalized Medicine, 2020
Response to sertraline is influenced by GNβ3 gene G-350A variant in patients with major depressive disorder
Dena Firouzabadi, Negar Firouzabadi, Kiana Kalani, Kamyar Zomorrodian, Elham Shirazi Tehrani
European Journal of Clinical Pharmacology, 2019
Response to the letter to the editor
Archives of Iranian Medicine, 2018
Metformin treatment prevents gallstone formation but mimics porcelain gallbladder in C57Bl/6 mice
Mohammad Reza Dorvash, Mohammad Javad Khoshnood, Hossein Saber, Amirreza Dehghanian, Pouria Mosaddeghi, Negar Firouzabadi
European Journal of Pharmacology, 2018
Glucocorticoid receptor genetic variants and response to fluoxetine in major depressive disorder
Hasti Nouraei, Negar Firouzabadi, Ali Mandegary, Kamiar Zomorrodian, Ehsan Bahramali, Mohammad Reza Hooshangi Shayesteh, Saham Ansari
Journal of Neuropsychiatry and Clinical Neurosciences, 2018
DRD3 Ser9Gly polymorphism and its influence on risperidone response in autistic children
Negar Firouzabadi, Anna Nazariat, Kamiar Zomorrodian
Journal of Pharmacy and Pharmaceutical Sciences, 2017
Association of renin–angiotensin–aldosterone system gene polymorphisms with left ventricular hypertrophy in patients with heart failure with preserved ejection fraction: A case–control study
Ehsan Bahramali, Negar Firouzabadi, Mona Rajabi, Alireza Manafi, Mehrdad Zarghami, Seyyed Mohammad Mousavi, Javad Jamshidi
Clinical and Experimental Hypertension, 2017
Beta adrenoceptor polymorphism and clinical response to sertraline in major depressive patients
Negar Firouzabadi, Roshanak Raeesi, Kamiar Zomorrodian, Ehsan Bahramali, Ilnaz Yavarian
Journal of Pharmacy and Pharmaceutical Sciences, 2017
Evaluating the Role of Drug Metabolism and Reactive Intermediates in Trazodone-Induced Cytotoxicity toward Freshly-Isolated Rat Hepatocytes
A. Najibi, R. Heidari, J. Zarifi, A. Jamshidzadeh, N. Firoozabadi, H. Niknahad
Drug Research, 2016
Influence of ACE gene on differential response to sertraline versus fluoxetine in patients with major depression: a randomized controlled trial
Ehsan Bahramali, Negar Firouzabadi, Ilnaz Yavarian, Mohammad Reza Hooshangi Shayesteh, Nasrallah Erfani, Ali Alavi Shoushtari, Roja Asadpour
European Journal of Clinical Pharmacology, 2016
Association of ACE gene D polymorphism with left ventricular hypertrophy in patients with diastolic heart failure: A case-control study
Ehsan Bahramali, Mona Rajabi, Javad Jamshidi, Seyyed Mohammad Mousavi, Mehrdad Zarghami, Alireza Manafi, Negar Firouzabadi
BMJ Open, 2016
Genetic variants of angiotensin-converting enzyme are linked to autism: A case-control study
Negar Firouzabadi, Nima Ghazanfari, Ali Alavi Shoushtari, Nasrallah Erfani, Farshid Fathi, Mozhdeh Bazrafkan, Ehsan Bahramali
Plos One, 2016
Renin-angiotensin system genetic polymorphisms: Lack of association with CRP levels in patients with coronary artery disease
Ehsan Bahramali, Negar Firouzabadi, Nematollah Jonaidi-Jafari, Massoumeh Shafiei
JRAAS Journal of the Renin Angiotensin Aldosterone System, 2014
Gender specificity of a genetic variant of angiotensin-converting enzyme and risk of coronary artery disease
Negar Firouzabadi, Nader Tajik, Ehsan Bahramali, Hooman Bakhshandeh, Mohsen Maadani, Massoumeh Shafiei
Molecular Biology Reports, 2013
Association of angiotensin-converting enzyme (ACE) gene polymorphism with elevated serum ACE activity and major depression in an Iranian population
Negar Firouzabadi, Massoumeh Shafiei, Ehsan Bahramali, Soltan Ahmed Ebrahimi, Hooman Bakhshandeh, Nader Tajik
Psychiatry Research, 2012
Association of angiotensin-converting enzyme polymorphism with coronary artery disease in Iranian patients with unipolar depression
Negar Firouzabadi, Nader Tajik, Ehsan Bahramali, Hooman Bakhshandeh, Soltan Ahmed Ebrahimi, Mohsen Maadani, Maryam Rasoulian, Tahereh Mobasheri, Massoumeh Shafiei
Clinical Biochemistry, 2012
Interaction of A-240T and A2350G related genotypes of angiotensin- converting enzyme (ACE) is associated with decreased serum ACE activity and blood pressure in a healthy Iranian population
Negar Firouzabadi, Nader Tajik, Massoumeh Shafiei, Soltan Ahmed Ebrahimi, Hooman Bakhshandeh
European Journal of Pharmacology, 2011
Neurological complications of first 100 orthotopic liver transplantation patients in Southern Iran
A. Borhani Haghighi, S.A. Malekhoseini, E. Bahramali, N. Firouzabadi, H. Salahi, A. Bahador, J. Roozbeh, M. Saber Firuzi, K.B. Lankarani, A.R. Nikseresht, H. Ashkani, P. Janghorban
Transplantation Proceedings, 2005

RECENT SCHOLAR PUBLICATIONS

Repurposing melatonin for its potential roles in gastrointestinal cancers: highlighting the molecular mechanisms
K Yousefipour, SS Razavi Rohani, SMM Hosseini, K Kafilzadeh, NS Alavi, ...
Cancer Cell International , 2026
2026
Evaluation of the circulating levels of IL-33 in patients with osteoarthritis: role of rs1929992 variants
N Alimoradi, F Jahankhah, H Jokardarzi, M Tahami, N Firouzabadi
Cytokine 194, 156996 , 2025
2025
Investigation on the association between Osteopontin and Apolipoprotein E gene polymorphisms and vancomycin-induced acute kidney injury: a pharmacokinetic/pharmacogenetic study …
N Firouzabadi, D Karbasi, P Ghasemiyeh, F Sadeghi, N Alimoradi, ...
Gene 952, 149386 , 2025
2025
Citations: 3
A pharmaceutical perspective on the potential of monkeypox outbreak to tackle future pandemics
A Dehshahri, S Hossaini Alhashemi, Z Taheri, N Firouzabadi
Trends in Pharmaceutical Sciences and Technologies , 2025
2025
Binding interaction of food preservatives with glycosylated DNA: In vitro assessment and computational studies
L Emami, S Hoshyar, S Bina, F Zare, P Mardaneh, M Haghshenas, ...
Journal of Molecular Structure 1324, 140824 , 2025
2025
Citations: 3
Comparison between Inhibition of CatSper and KSper Channels with NNC 55-0396 and Quinidine on Human Sperm Function
AA Zarei, S Keshtgar, M Haghani, N Firouzabadi, MH Nasr-Esfahani
Iranian Journal of Medical Sciences 50 (3), 187 , 2025
2025
Citations: 1
EUR Research Information Portal
N Firouzabadi, D Karbasi, P Ghasemiyeh, F Sadeghi, N Alimoradi, ...
Gene 952, 149386 , 2025
2025
Metformin exhibits anti‐inflammatory effects by regulating microRNA‐451/CXCL16 and B cell leukemia/lymphoma 2 in patients with osteoarthritis
N Alimoradi, A Ramezani, M Tahami, N Firouzabadi
ACR open rheumatology 7 (1), e11755 , 2025
2025
Citations: 10
Smart nanogels as promising platform for delivery of drug, gene, and vaccine; therapeutic applications and active targeting mechanism
F Farjadian, S Mirkiani, P Ghasemiyeh, HR Kafshboran, ...
European Polymer Journal 219, 113400 , 2024
2024
Citations: 41
Modulation of ACE2/Ang1-7/Mas and ACE/AngII/AT1 axes affects anticancer properties of sertraline in MCF-7 breast cancer cells
R Fatehi, M Nouraei, M Panahiyan, M Rashedinia, N Firouzabadi
Biochemistry and Biophysics Reports 38, 101738 , 2024
2024
Citations: 12
Signaling pathways and genetics of brain Renin angiotensin system in psychiatric disorders: State of the art
R Barak, G Goshtasbi, R Fatehi, N Firouzabadi
Pharmacology Biochemistry and Behavior 236, 173706 , 2024
2024
Citations: 8
Polymorphism of glucocorticoid receptor gene ( rs41423247 ) in functional seizures (psychogenic nonepileptic seizures/attacks)
N Firouzabadi, AA Asadi‐Pooya, N Alimoradi, L Simani, M Asadollahi
Epilepsia Open 8 (4), 1425-1431 , 2023
2023
Citations: 9
Polymorphism of glucocorticoid receptor gene (rs41423247) in functional seizures
N Firouzabadi, A Asadi-Pooya, N Alimoradi, L Simani, M Asadollahi
EPILEPSIA 64, 543-543 , 2023
2023
Combination of metformin and gallic acid induces autophagy and apoptosis in human breast cancer cells
M Haghshenas, N Firouzabadi, AR Akbarizadeh, M Rashedinia
Research in Pharmaceutical Sciences 18 (6), 663-675 , 2023
2023
Citations: 14
The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies
B Hassani, Z Attar, N Firouzabadi
Cancer Cell International 23 (1), 254 , 2023
2023
Citations: 79
The Effective Participation of a Clinical Pharmacist in Detecting Medication Errors in the COVID-19 Intensive Care Unit
D Firouzabadi, SM Hosseini Saadi, N Firouzabadi
Trends in Pharmaceutical Sciences and Technologies 9 (3), 171-182 , 2023
2023
The effect of size, morphology and surface properties of mesoporous silica nanoparticles on pharmacokinetic aspects and potential toxicity concerns
U Niroumand, N Firouzabadi, G Goshtasbi, B Hassani, P Ghasemiyeh, ...
Frontiers in Materials 10, 1189463 , 2023
2023
Citations: 88
FKBP5 blockade may provide a new horizon for the treatment of stress‐associated disorders: An in‐silico study
AA Asadi‐Pooya, M Malekpour, B Zamiri, M Kashkooli, N Firouzabadi
Epilepsia Open 8 (2), 633-640 , 2023
2023
Citations: 9
Potential role of FKBP5 single‐nucleotide polymorphisms in functional seizures
AA Asadi‐Pooya, L Simani, M Asadollahi, FS Rashidi, E Ahmadipour, ...
Epilepsia Open 8 (2), 479-486 , 2023
2023
Citations: 16
Update on the effectiveness of COVID-19 vaccines on different variants of SARS-CoV-2
N Firouzabadi, P Ghasemiyeh, F Moradishooli, S Mohammadi-Samani
International immunopharmacology 117, 109968 , 2023
2023
Citations: 125

MOST CITED SCHOLAR PUBLICATIONS

Update on the effectiveness of COVID-19 vaccines on different variants of SARS-CoV-2
N Firouzabadi, P Ghasemiyeh, F Moradishooli, S Mohammadi-Samani
International immunopharmacology 117, 109968 , 2023
2023
Citations: 125
A focused review on technologies, mechanisms, safety, and efficacy of available COVID-19 vaccines
P Ghasemiyeh, S Mohammadi-Samani, N Firouzabadi, A Dehshahri, ...
International immunopharmacology 100, 108162 , 2021
2021
Citations: 125
The effect of size, morphology and surface properties of mesoporous silica nanoparticles on pharmacokinetic aspects and potential toxicity concerns
U Niroumand, N Firouzabadi, G Goshtasbi, B Hassani, P Ghasemiyeh, ...
Frontiers in Materials 10, 1189463 , 2023
2023
Citations: 88
The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies
B Hassani, Z Attar, N Firouzabadi
Cancer Cell International 23 (1), 254 , 2023
2023
Citations: 79
SNPs of ACE1 (rs4343) and ACE2 (rs2285666) genes are linked to SARS-CoV-2 infection but not with the severity of disease
N Alimoradi, M Sharqi, D Firouzabadi, MM Sadeghi, MI Moezzi, ...
Virology Journal 19 (1), 48 , 2022
2022
Citations: 63
Association of ACE gene D polymorphism with left ventricular hypertrophy in patients with diastolic heart failure: a case–control study
E Bahramali, M Rajabi, J Jamshidi, SM Mousavi, M Zarghami, A Manafi, ...
BMJ open 6 (2), e010282 , 2016
2016
Citations: 60
Association of angiotensin-converting enzyme (ACE) gene polymorphism with elevated serum ACE activity and major depression in an Iranian population
N Firouzabadi, M Shafiei, E Bahramali, SA Ebrahimi, H Bakhshandeh, ...
Psychiatry research 200 (2-3), 336-342 , 2012
2012
Citations: 56
Metformin attenuates symptoms of osteoarthritis: role of genetic diversity of Bcl2 and CXCL16 in OA
N Alimoradi, M Tahami, N Firouzabadi, E Haem, A Ramezani
Arthritis Research & Therapy 25 (1), 35 , 2023
2023
Citations: 42
Smart nanogels as promising platform for delivery of drug, gene, and vaccine; therapeutic applications and active targeting mechanism
F Farjadian, S Mirkiani, P Ghasemiyeh, HR Kafshboran, ...
European Polymer Journal 219, 113400 , 2024
2024
Citations: 41
Metformin enhances anti-cancer properties of resveratrol in MCF-7 breast cancer cells via induction of apoptosis, autophagy and alteration in cell cycle distribution
R Fatehi, M Rashedinia, AR Akbarizadeh, N Firouzabadi
Biochemical and Biophysical Research Communications 644, 130-139 , 2023
2023
Citations: 39
Metformin and insulin-resistant related diseases: Emphasis on the role of microRNAs
N Alimoradi, N Firouzabadi, R Fatehi
Biomedicine & Pharmacotherapy 139, 111662 , 2021
2021
Citations: 39
Genetic variants of angiotensin-converting enzyme are linked to autism: a case-control study
N Firouzabadi, N Ghazanfari, A Alavi Shoushtari, N Erfani, F Fathi, ...
PloS one 11 (4), e0153667 , 2016
2016
Citations: 37
Association of renin–angiotensin–aldosterone system gene polymorphisms with left ventricular hypertrophy in patients with heart failure with preserved ejection fraction: a case …
E Bahramali, N Firouzabadi, M Rajabi, A Manafi, M Zarghami, ...
Clinical and Experimental Hypertension 39 (4), 371-376 , 2017
2017
Citations: 36
Influence of ACE gene on differential response to sertraline versus fluoxetine in patients with major depression: a randomized controlled trial
E Bahramali, N Firouzabadi, I Yavarian, MRH Shayesteh, N Erfani, ...
European journal of clinical pharmacology 72 (9), 1059-1064 , 2016
2016
Citations: 33
Association of angiotensin-converting enzyme polymorphism with coronary artery disease in Iranian patients with unipolar depression
N Firouzabadi, N Tajik, E Bahramali, H Bakhshandeh, SA Ebrahimi, ...
Clinical biochemistry 45 (16-17), 1347-1352 , 2012
2012
Citations: 32
Drug-based therapeutic strategies for COVID-19-infected patients and their challenges
K Zarkesh, E Entezar-Almahdi, P Ghasemiyeh, M Akbarian, M Bahmani, ...
Future Microbiology 16 (18), 1415-1451 , 2021
2021
Citations: 28
ncRNAs and polyphenols: new therapeutic strategies for hypertension
E Shirazi-Tehrani, A Chamasemani, N Firouzabadi, M Mousaei
RNA biology 19 (1), 575-587 , 2022
2022
Citations: 27
How metformin affects various malignancies by means of microRNAs: a brief review
N Alimoradi, N Firouzabadi, R Fatehi
Cancer Cell International 21 (1), 207 , 2021
2021
Citations: 26
A longitudinal item response model for aberrant behavior checklist (ABC) data from children with autism
E Haem, M Doostfatemeh, N Firouzabadi, N Ghazanfari, MO Karlsson
Journal of Pharmacokinetics and Pharmacodynamics 47 (3), 241-253 , 2020
2020
Citations: 26
Pharmacogenetic‐based management of depression: Role of traditional Persian medicine
A Jalali, N Firouzabadi, MM Zarshenas
Phytotherapy Research 35 (9), 5031-5052 , 2021
2021
Citations: 25

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