Immunology and Allergy, General Medicine, Infectious Diseases, Internal Medicine
10
Scopus Publications
Scopus Publications
MEDICAL REHABILITATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN PATIENTS WITH HELICOBACTERIOSIS I.V. Loskutova, N.P. Karandash Phytotherapy Journal, 2021 The article presents the results of the study of metabolic endogenous intoxication (MEI) indicators -molecules of average mass (MSM), anti-inflammatory cytokines IL-6, IL-8 and IL-10, and their correlation with cognitive disorders, and also investigates the dynamics of these indicators and regression of cognitive disorders against the proposed scheme of low volume infusion detoxification therapy with hyperosmolar balanced crystalloid in the context of a 30-day period.
New aspects in the pathogenesis of miscarriage in women with extragenital pathology I.V. Loskutova, R.G. Bichevska, N.G. Korniiets Reproductive Endocrinology, 2021 Study objective: to determine the dynamics of type 9 metalloproteinase (MMP-9) and its tissue inhibitor-1 (TIMP-1) in the pathogenesis of early miscarriage in women with chronic diseases of the hepatobiliary system.Materials and methods. The study included 39 women with a history of early pregnancy miscarriage, who were diagnosed with chronic liver diseases as a result of clinical, instrumental and laboratory studies (17 persons with steatosis and 22 persons with non-alcoholic steatohepatitis). The control group consisted of 8 women without somatic pathology and 8 pregnant women at the first trimester of gestation. MMP-9 and TIMP-1 value in the blood serum was determined by the enzyme immunoassay.Results. MMP-9 and TIMP-1 growth in the blood serum of women with a history of miscarriage was established in the pre-gravidar period. The most significant increase in the parameters of the intercellular matrix was found in patients with non-alcoholic steatohepatitis. MMP-9 and TIMP-1 increased in in blood serum in the first trimester in women with liver diseases. MMP-9 increased against the background of a decrease in the TIMP-1 activity in patients with the threat of premature pregnancy termination. Miscarriage was diagnosed in patients with a minimum value of a tissue inhibitor. Conclusions. There is an imbalance between MMP-9 and TIMP-1 in the blood serum in women with early miscarriage and chronic diseases of the hepatobiliary system. MMP-9 and TIMP-1 level in patients with hepatic steatosis is lower than in patients with non-alcoholic steatohepatitis. MMP-9 increased during physiological pregnancy, and the TIMP-1 activity practically did not change, which indicates the role of MMP-9 in the initial stages of placentation. MMP-9 value in women with a burdened premorbid background with a physiological course of pregnancy and threatening early spontaneous miscarriage was significantly different. The highest activity of MMP-9 was in women with the threat of spontaneous miscarriage in the early stages. TIMP-1 in the first trimester in women with chronic liver disease increased in those with a favorable course of pregnancy and decreased in the threat of spontaneous miscarriage. Such changes in MMP-9 and TIMP-1 in patients with miscarriage indicate the accumulation of intercellular matrix and sclerotic changes in the vessels that provide blood to the uterus.
Changes in the cytokine status in women with chronic liver pathology during reproductive losses in the first trimester I.V. Loskutova, R.G. Bichevska, N.V. Matsiukh Reproductive Endocrinology, 2021 Research objective: to determine the level of serum cytokines in the pregravidar period in women with chronic diseases of the hepatobiliary system and reproductive losses in the first trimester in the anamnesis.Materials and methods. 90 patients of reproductive age with chronic pathology of the hepatobiliary system (liver steatosis and non-alcoholic steatohepatitis) were examined. All patients had spontaneous miscarriages in the early stages of gestation in anamnesis. The research was conducted during the pregravid preparation period. The laboratory research included an additional study of the interleukins (ІL-2, ІL-6, ІL-8, ІL-10) and tumor necrosis factor (TNFα) in the blood serum using enzyme immunoferment assay. 8 female donors were examined to determine the reference norm of cytokines in the blood serum. Results. The cytokine status in patients with chronic pathology of the hepatobiliary system against the background of early miscarriage was characterized by an increase in proinflammatory cytokines (TNFα in 2,29 times more, ІL-2 in 1,46 times, ІL-6 in 1,84 times and ІL-8 in 1,50 times) and anti-inflammatory cytokines (ІL-10 in 1,31 times). The integral indices that are characterizing the oppositional cytokines ratio increased (TNFα/ІL-10, ІL-2/ІL-10 and ІL-6/ІL-10) which indicates an inflammatory process in the body. Minimal changes were registered in patients with signs of steatosis – a moderate increase in proinflammatory cytokines (TNFα is 1,34 times more, ІL-2 in 1,18 times, ІL-6 in 1,33 times and ІL-8 in 1,13 times) and preservation within the reference norm of ІL-10. The maximum imbalance of serum cytokines was observed in the exacerbation of non-alcoholic steatohepatitis – a significant increase in proinflammatory cytokines (TNFα is 3,66 times more, ІL-2 in 1,95 times, ІL-6 in 2,57 times and ІL-8 in 2,18 times) against the background of a moderate increase in ІL-10 (1,30 times). In patients with clinical and laboratory signs of remission of non-alcoholic steatohepatitis a moderate increase in proinflammatory (TNFα is 1,87 times more, ІL-2 in 1,20 times, ІL-6 in 1,61 times and ІL-8 in 1,20 times) and anti-inflammatory (ІL-10 in 1,51 times) cytokines was diagnosed. The analysis of the integral indices of oppositional cytokines showed a tendency to increase their values in patients with liver steatosis and non-alcoholic steatohepatitis in the phase of clinical and laboratory remission. During the period of the non-alcoholic steatohepatitis exacerbation a considerable increase in the studied coefficients was revealed. Conclusions. Changes in the cytokine status are noted in patients with early spontaneous miscarriages in anamnesis and chronic diseases of the hepatobiliary system, which are characterized by the severity of inflammatory reactions and progression of the pathological process in liver. Obtained results can be used to predict miscarriage and be taken into account in the program of drug preparation in the pregravid period.
The specific features of vegetative disorders in the children presenting with rhinosinusitis E. G. Chashcheva, I. V. Loskutova Vestnik Otorinolaringologii, 2015 The authors examined 79 children presenting with rhinosinusitis. The objective of the study was to evaluate the state of the autonomous nervous system in these patients. The vegetative tone was determined with the use of the Wayne tables and questionnaires based on the results of the Preveli and Danielopulo tests. The functional condition of the myocardium was assessed by ECG and echocardiography. It was shown that the acute period of rhinosinusitis was more frequently associated with the development of asthenoneurotic syndrome, emotional lability, and changes of arterial pressure than with other symptoms of vegetative dysfunction. The pathological changes suggesting the functional disorders were recorded on ECG in 63.3% of the patients while the echocardiographic studies revealed alterations in the valvular apparatus in 40.5% of the cases.
[Influence of phytotherapy on pro- and antioxidant status in spermatozoa, seminal plasma and immunologic status of sperm in men with chronic inflammation of the urogenital tract complicated by infertility]. Likars Ka Sprava Ministerstvo Okhorony Zdorov Ia Ukrainy, 2013
[State of local immunity in herpetic stomatitis patients]. Likars Ka Sprava Ministerstvo Okhorony Zdorov Ia Ukrainy, 2013
[Markers of active inflammation in patients with chronic bronchitis in combination with insulin resistance]. Likars Ka Sprava Ministerstvo Okhorony Zdorov Ia Ukrainy, 2012
The efficacy of amizon in the combined treatment of patients with epidemic parotitis Likars Ka Sprava Ministerstvo Okhorony Zdorov Ia Ukrainy, 1999
Viral hepatitis A, E and their mix (A+E) in children Likars Ka Sprava Ministerstvo Okhorony Zdorov Ia Ukrainy, 1998
