Kata Horvati

Scopus Publications

An ATP-Mediated Antibiotic β-Peptide Nanofiber That Kills Multidrug-Resistant Bacteria via a Multistage Mechanism
Sohini Chakraborty, Kamal el Battioui, Dániel Molnár, Bálint Jezsó, Lejla Daruka, Tasvilla Sonallya, Tünde Juhász, Rita Hirmondó, Imola Cs. Szigyártó, Loránd Románszki, Natália Tőkési, Daniel Pinkas, Eszter Házy, Olivér Pavela, Andrea Bodor, Zoltán Varga, István Mándity, Mihály Kovács, Csaba Pál, Kata Horváti, Judit Tóth, Tamás Beke‐Somfai
Advanced Science, 2026
Artificial bioinspired supramolecular assemblies hold great potential to alter modern medicine. Organic tissue‐like nanomaterials built from foldamer peptidomimetics and natural biomolecules could expand our boundaries toward new biocompounds that are able to address global health challenges. Related, antimicrobial resistance against conventional antibiotics motivates search for new compounds with orthogonal mechanisms. Here we designed an antibacterial system where natural adenosine phosphates (APs) trigger supramolecular co‐assemblies from a lipopolysaccharide‐targeting (LPS) antimicrobial β 3 ‐peptide (3K). Cryo‐EM and confocal microscopy images on E. coli confirmed that real‐time action of 3K‐APs progresses via a multiscale mechanism. Initially, entangled nanofibers capture bacteria resulting in agglutination. Further, individual cells become enwrapped, undergoing a reduction in cell height, as observed by AFM. Finally, in situ cryo‐EM observations, offering insight into their structural state in solution, suggest an association between the presence of extracellular vesicles and loss of cell integrity, which may contribute to cell death. 3K‐ATP was tested on multidrug resistant bacterial strains which adapted to membrane‐targeting antibiotics, where only limited cross‐resistance was observed. Resistant strains modifying their LPS even showed increased sensitivity. Besides induced disassembly by target membranes, degradation could also be reached through enzymatic hydrolysis of APs, altogether resulting in supramolecular bactericides with controllable build‐up and clearance.
Thermoresponsive Graft Copolymers of N-Isopropylacrylamide and Hyperbranched Polyglycerol as Thermally Induced Drug Delivery and Release Nanoformulation Systems for Curcumin with High Colloidal Stability and Enhanced Anticancer Effect
György Kasza, Ákos Fábián, Dóra Fecske, Anna Petróczy, Kata Horváti, Béla Iván
ACS Omega, 2026
High Resolution Image Download MS PowerPoint Slide The poor solubility, stability issues, and restricted bioavailability of numerous drugs and potential pharmaceutical compounds highlight the critical need for the development of polymeric nanoparticles as effective drug delivery systems. Ideal polymers for such applications must be biocompatible, provide controlled drug loading and release, and maintain the high colloidal stability of the nanoformulation. In this study, LCST-type thermoresponsive poly( N -isopropylacrylamide)- g -(hyperbranched polyglycerol) (PNiPAAm- g -HbPG) graft copolymers, composed of two biocompatible components, were synthesized by grafting amino-monofunctional HbPG, prepared by multibranching anionic ring-opening polymerization, onto PNiPAAm chains containing succinimide active ester groups. In both aqueous solutions and phosphate-buffered saline, these graft copolymers undergo reversible aggregation and disaggregation in response to temperature changes, with linear increase of the critical solution temperature (CST) as a function of grafting density. The architecture of the copolymers enables efficient encapsulation of curcumin, a natural anticancer agent, by a simple mixing process at elevated temperatures, and the hydrophilic HbPG side chains provide excellent colloidal stability for the polymer–drug nanoformulations. Sustained release of curcumin from the PNiPAAm- g -HbPG aggregates was found, which depends on the grafting density, and the release rate can be externally triggered by decreasing the temperature. The potential biocompatibility of the PNiPAAm- g -HbPG graft copolymers was demonstrated in vitro, with no evidence of cytotoxicity or hemolytic activity against human cells. The nanoformulations of curcumin with these new graft copolymers enhanced its internalization into HT-29 human colorectal adenocarcinoma cells and significantly improved its cytostatic effect against colon cancer cells. These properties of the novel PNiPAAm- g -HbPG graft copolymers make them superior candidates for advanced drug encapsulation and delivery systems.
Spatiotemporal control in biomedicine: photoswitchable peptides and foldamers
Eszter Erdei, Juan Toledo Marcos, Nikolett Varró, Kata Horváti, Bernadett Bacsa, István M. Mándity
British Journal of Pharmacology, 2025
Photopharmacology integrates light‐based technology with pharmacology to achieve precise control over biological processes, offering non‐invasive activation and spatiotemporal regulation of biomolecular activity. Within this field, photoswitchable peptides and foldamers provide a powerful approach in precision medicine, enabling reversible conformational changes that toggle between active and inactive states. This light‐driven modulation enhances targeted drug delivery, molecular sensing, and the development of photoresponsive biomaterials and optical devices. These dynamic systems hold immense potential for creating ‘smart’ therapeutics and biomaterials that adapt to environmental cues, revolutionizing biomedical applications. However, challenges persist in optimizing their stability, specificity and responsiveness in complex biological environments. Advances in light‐responsive technologies and nanotechnology continue to push the boundaries of their applications, driving innovation in precision medicine and materials science. As research progresses, these systems are poised to transform drug delivery, diagnostics and next‐generation biomaterials.
Self-Assembling Amphiphilic ABA Triblock Copolymers of Hyperbranched Polyglycerol with Poly(tetrahydrofuran) and Their Nanomicelles as Highly Efficient Solubilization and Delivery Systems of Curcumin
Dóra Fecske, György Kasza, Gergő Gyulai, Kata Horváti, Márk Szabó, András Wacha, Zoltán Varga, Györgyi Szarka, Yi Thomann, Ralf Thomann, Rolf Mülhaupt, Éva Kiss, Attila Domján, Szilvia Bősze, Laura Bereczki, Béla Iván
International Journal of Molecular Sciences, 2025
Delivering of hydrophobic drugs by polymeric nanoparticles is an intensively investigated research and development field worldwide due to the insufficient solubility of many existing and potential new drugs in aqueous media. Among polymeric nanoparticles, micelles of biocompatible amphiphilic block copolymers are among the most promising candidates for solubilization, encapsulation, and delivery of hydrophobic drugs to improve the water solubility and thus the bioavailability of such drugs. In this study, amphiphilic ABA triblock copolymers containing biocompatible hydrophilic hyperbranched (dendritic) polyglycerol (HbPG) outer and hydrophobic poly(tetrahydrofuran) (PTHF) inner segments were synthesized using amine-telechelic PTHF as a macroinitiator for glycidol polymerization. These hyperbranched–linear–hyperbranched block copolymers form nanosized micelles with 15–20 nm diameter above the critical micelle concentration. Coagulation experiments proved high colloidal stability of the aqueous micellar solutions of these block copolymers against temperature changes. The applicability of block copolymers as drug delivery systems was investigated using curcumin, a highly hydrophobic, water-insoluble, natural anti-cancer agent. High and efficient drug solubilization up to more than 3 orders of magnitude to that of the water solubility of curcumin (>1500-fold) is achieved with the HbPG-PTHF-HbPG block copolymer nanomicelles, locating the drug in amorphous form in the inner PTHF core. Outstanding stability of and sustained curcumin release from the drug-loaded block copolymer micelles were observed. The in vitro bioactivity of the curcumin-loaded nanomicelles was investigated on U-87 glioblastoma cell line, and an optimal triblock copolymer composition was found, which showed highly effective cellular uptake and no toxicity. These findings indicate that the HbPG-PTHF-HbPG triblock copolymers are promising candidates for advanced drug solubilization and delivery systems.
Charge and length dependent build-up of environment sensitive lamellin β-peptides
Sohini Chakraborty, Kamal el Battioui, Tasvilla Sonallya, Imola Cs. Szigyártó, Kata Horváti, Zoltán Varga, Tünde Juhász, Tamás Beke-Somfai
Physical Chemistry Chemical Physics, 2025
Minor sequence modifications introduce morphological and conformational diversity in heterochiral lamellin β3-peptides; an insight into the design of supramolecules with future potential for targeted biological activity.
Supramolecular Complexes of Ultrashort Cationic Lipopeptides with Cyclodextrins: Improved Selectivity and Therapeutic Potential
Chiara Bellini, Unai Atxabal, Szilvia Bősze, Orsolya Dobay, Andrea Horváth, Imola Cs. Szigyártó, Tamás Beke‐Somfai, Jesús Jiménez‐Barbero, István Puskás, Kata Horváti
Aggregate, 2025
In the last decade, the rise of antibiotic resistance has heightened interest in antimicrobial peptides and lipopeptides as promising alternatives to conventional antibiotics because of their lower propensity to develop resistance. However, lipopeptides often show undesired cytotoxicity due to their non‐selective membrane disruptive effect, and their limited aqueous solubility represents a matter of concern from a pharmaceutical point of view. This study demonstrates a panel of ultrashort cationic lipopeptides (USCLs) consisting of a tetrapeptide (L1), originated from buforin II, coupled with saturated fatty acids of different lengths. Our results highlight that the 16‐carbon fatty acid lipopeptide (Pal‐L1) exhibits relevant antibacterial activity against multiresistant Staphylococcus aureus strain. However, the formation of heterogenic aggregates in cell culture medium and toxic effects on human cells were also observed. Pal‐L1 formulation with the randomly methylated α‐cyclodextrin (RAMEA) and the sulfobutylether‐β‐cyclodextrin (SBECD) has resulted in a production of ultralow‐sized molecular dispersion systems and reduced lipopeptide toxicity without compromising its antimicrobial activity. With titration 1H‐NMR, 2D NMR experiments, together with molecular dynamics simulations, we described the size, structure, stoichiometry, and dissociation constant of the supramolecular complexes. Interactions of neutral and negatively charged model liposomes with Pal‐L1 lipopeptide in the presence or absence of cyclodextrins serve an explanation for the membrane selectivity, and based on the results, we proposed a potential mechanism of action for the Pal‐L1+cyclodextrin complexes on different biological membranes. Overall, our model characterization points out that cyclodextrin formulation improves the therapeutical applicability of lipopeptides.
Characterization and Biofungicide Potential of a Novel Antifungal defensin, K4CBP6, from Solanum lycopersicum L.
Rebeka Papp, Péter Poór, Zalán Czékus, Györgyi Váradi, Zoltán Kele, Attila Borics, Gábor Bende, Kata Horváti, Gábor K. Tóth, László Galgóczy, Liliána Tóth
Probiotics and Antimicrobial Proteins, 2025
The global rise in resistance to chemical fungicides and their strict regulation by the EU, has created an urgent need for alternative antifungal strategies in agriculture. Plant defensins represent promising alternatives owing to their broad-spectrum antifungal activity, structural stability, and low toxicity to mammalian cells and plants. In this study, we identified and characterized a novel antifungal defensin, K4CBP6, from Solanum lycopersicum L., along with its γ-core peptide derivatives, K4CBP6γ1 and K4CBP6γ2, as potential biofungicide agents. Protein database mining revealed a widespread distribution of K4CBP6 homologs within the Solanaceae family. Recombinant K4CBP6 (rK4CBP6) was successfully produced using a Komagataella phaffii -based expression system, while K4CBP6γ1 and K4CBP6γ2 were chemically synthesized. Structural analyses via electrospray ionization mass spectrometry and electronic circular dichroism spectroscopy confirmed a cysteine-stabilized α-helix β-strand folded structure for rK4CBP6. In vitro susceptibility assays demonstrated that both rK4CBP6 and K4CBP6γ2 exhibited antifungal activity against major tomato pathogens, Botrytis cinerea , Cladosporium herbarum , and Fusarium oxysporum with minimum inhibitory concentrations ranging from 12.5 to 25 µg ml -1 . Furthermore, neither rK4CBP6 nor K4CBP6γ2 exhibited cytotoxic effects on mammalian cell lines or adverse effects in animal and plant model systems even at concentrations of 200 and 400 µg ml -1 . Proof-of-concept experiments on tomato plants and fruits confirmed their protective efficacy against B. cinerea and C. herbarum . These findings highlight the potential of rK4CBP6 and K4CBP6γ2 as sustainable biofungicide candidates for plant disease management, owing to their antifungal efficacy both in vitro and in planta, along with their lack of cytotoxic effects.
Optimizing lipopeptide bioactivity: The impact of non-ionic surfactant dressing
Ágnes Ábrahám, Gergő Gyulai, Judith Mihály, Andrea Horváth, Orsolya Dobay, Zoltán Varga, Éva Kiss, Kata Horváti
Journal of Pharmaceutical Analysis, 2024
The aim of the research is to increase the applicability of lipopeptides as drugs. To this end, non-ionic triblock copolymers, namely poloxamers, were applied. The physico-chemical properties of poloxamers vary depending on the length of the blocks. In our study, we experimented with different types and systematically investigated the variation of the critical micelle concentration (CMC) of poloxamers at 25 and 37 °C in different media. In addition, the cytotoxicity of the different poloxamer micelles on three different cell lines was evaluated, and based on the results, Plur104, Plur123, and Plur127 were selected. Fatty acid elongated derivatives of a short antibacterial peptide (pL1), a medium-sized anticancer peptide (pCM15), and a branched-chain vaccine antigen (pATIPC) were used as lipopeptide models, and their formulations with the selected poloxamers were investigated. The solubility and homogeneity of the lipopeptides were significantly increased, and dynamic light scattering (DLS) measurements showed the formation of small particles of around 20 nm, which were well reproducible and storable. Similar homogenous micelle formation was observed after freeze-drying and reconstitution with water. The pL1 lipopeptide, formulated with the selected poloxamers, exhibited enhanced antibacterial activity with significantly reduced haemolytic side effects. The pCM15 peptide, when incorporated into poloxamer micelles, showed significantly enhanced cytotoxicity against tumor cells. Additionally, the internalization rate of poloxamer-formulated pATIPC peptide by antigen-presenting model cells exceeded that of the unformulated peptide. Our results demonstrate the potential of poloxamers as promising tools for the formulation of lipopeptides and for the optimization of their selectivity.
In situ captured antibacterial action of membrane-incising peptide lamellae
Kamal el Battioui, Sohini Chakraborty, András Wacha, Dániel Molnár, Mayra Quemé-Peña, Imola Cs. Szigyártó, Csenge Lilla Szabó, Andrea Bodor, Kata Horváti, Gergő Gyulai, Szilvia Bősze, Judith Mihály, Bálint Jezsó, Loránd Románszki, Judit Tóth, Zoltán Varga, István Mándity, Tünde Juhász, Tamás Beke-Somfai
Nature Communications, 2024
Developing unique mechanisms of action are essential to combat the growing issue of antimicrobial resistance. Supramolecular assemblies combining the improved biostability of non-natural compounds with the complex membrane-attacking mechanisms of natural peptides are promising alternatives to conventional antibiotics. However, for such compounds the direct visual insight on antibacterial action is still lacking. Here we employ a design strategy focusing on an inducible assembly mechanism and utilized electron microscopy (EM) to follow the formation of supramolecular structures of lysine-rich heterochiral β3-peptides, termed lamellin-2K and lamellin-3K, triggered by bacterial cell surface lipopolysaccharides. Combined molecular dynamics simulations, EM and bacterial assays confirmed that the phosphate-induced conformational change on these lamellins led to the formation of striped lamellae capable of incising the cell envelope of Gram-negative bacteria thereby exerting antibacterial activity. Our findings also provide a mechanistic link for membrane-targeting agents depicting the antibiotic mechanism derived from the in-situ formation of active supramolecules.
Hyperbranched polyglycerol grafted poly(N,N-diethylacrylamide) thermoresponsive copolymers as biocompatible, highly efficient encapsulation and sustained release systems of curcumin
György Kasza, Ákos Fábián, Dóra Fecske, Attila Kardos, Róbert Mészáros, Kata Horváti, Béla Iván
European Polymer Journal, 2024
Due to solubilization, encapsulation, stability and delivery difficulties of various drugs and drug candidates, investigating polymeric nanoparticles for drug delivery formulations is an extremely vital and challenging task. The ideal polymers should have biocompatibility, controlled drug uptake/release properties and colloidal stability over a wide temperature range. In this study, we propose poly(N,N-diethylacrylamide)-g-(hyperbranched polyglycerol) (PDEAAm-g-HbPG) thermoresponsive graft copolymers as candidates for drug formulations satisfying all the above-mentioned requirements. The PDEAAm-g-HbPG copolymers were synthesized by grafting amino-monofunctional HbPG onto PDEAAm chains containing pendant succinimide active ester groups. It has been found that the PDEAAm-g-HbPG graft copolymers are non-toxic to human monocytic cells, and do not cause haemolysis of human red blood cells. Furthermore, these grafts possess temperature-dependent reversible aggregation-disaggregation, i.e. thermoresponsive transitions, in water and PBS. The specific nanoassembling architecture of the copolymers resulted in enhanced encapsulation of curcumin with high drug loading content exceeding 25 % at 37 °C. The hydrophilic HbPG side chains provide high colloidal stability for the formulated drug dispersions from room temperature up to 45 °C as well as sustained release of curcumin. Formulating curcumin with these novel graft copolymers significantly enhanced its anticancer activity against HT-29 colorectal adenocarcinoma cells and the cell internalization of the drug. These properties of PDEAAm-g-HbPG copolymers make them superior compared to other hydrophilically modified polymer carriers indicating their great potential as advanced drug delivery systems.
Effective nanoparticulate-type encapsulation delivery system for hydrophilic proteins and peptides
Flavio Massignan, Gergő Gyulai, Kata Horváti, Szilvia Bősze, Éva Kiss
Express Polymer Letters, 2024
Bidirectional Allosteric Coupling between PIP2 Binding and the Pore of the Oncochannel TRPV6
Christina Humer, Tamara Radiskovic, Kata Horváti, Sonja Lindinger, Klaus Groschner, Christoph Romanin, Carmen Höglinger
International Journal of Molecular Sciences, 2024
Design and Characterization of a Multistage Peptide-Based Vaccine Platform to Target Mycobacterium tuberculosis Infection
Chiara Bellini, Emil Vergara, Fruzsina Bencs, Kinga Fodor, Szilvia Bősze, Denis Krivić, Bernadett Bacsa, Sára Eszter Surguta, József Tóvári, Rajko Reljic, Kata Horváti
Bioconjugate Chemistry, 2023
Arylnaphthalene Lignans with Anti-SARS-CoV-2 and Antiproliferative Activities from the Underground Organs of Linum austriacum and Linum perenne
Gergő Tóth, Kata Horváti, Márta Kraszni, Tim Ausbüttel, Bernadett Pályi, Zoltán Kis, Zoltán Mucsi, Gábor M. Kovács, Szilvia Bősze, Imre Boldizsár
Journal of Natural Products, 2023
Interplay between membrane active host defense peptides and heme modulates their assemblies and in vitro activity
Tünde Juhász, Mayra Quemé-Peña, Bence Kővágó, Judith Mihály, Maria Ricci, Kata Horváti, Szilvia Bősze, Ferenc Zsila, Tamás Beke-Somfai
Scientific Reports, 2021
Novel Assay Platform to Evaluate Intracellular Killing of Mycobacterium tuberculosis: In Vitro and In Vivo Validation
Kata Horváti, Kinga Fodor, Bernadett Pályi, Judit Henczkó, Gyula Balka, Gergő Gyulai, Éva Kiss, Beáta Biri-Kovács, Zsuzsanna Senoner, Szilvia Bősze
Frontiers in Immunology, 2021
Tissue-specific accumulation and isomerization of valuable phenylethanoid glycosides from Plantago and Forsythia plants
Moritz Zürn, Gergő Tóth, Tim Ausbüttel, Zoltán Mucsi, Kata Horváti, Szilvia Bősze, Magdolna Sütöri-Diószegi, Bernadett Pályi, Zoltán Kis, Béla Noszál, Imre Boldizsár
International Journal of Molecular Sciences, 2021
Comparison of the efficacy of two novel antitubercular agents in free and liposome-encapsulated formulations
Nikoletta Kósa, Ádám Zolcsák, István Voszka, Gabriella Csík, Kata Horváti, Lilla Horváth, Szilvia Bősze, Levente Herenyi
International Journal of Molecular Sciences, 2021
Cost-Effective Flow Peptide Synthesis: Metamorphosis of HPLC
Viktor Farkas, Kristóf Ferentzi, Kata Horváti, András Perczel
Organic Process Research and Development, 2021
Old Polyanionic Drug Suramin Suppresses Detrimental Cytotoxicity of the Host Defense Peptide LL-37
Mayra Quemé-Peña, Maria Ricci, Tünde Juhász, Kata Horváti, Szilvia Bősze, Beáta Biri-Kovács, Bálint Szeder, Ferenc Zsila, Tamás Beke-Somfai
ACS Pharmacology and Translational Science, 2021
Recent advances in the development of protein-and peptide-based subunit vaccines against tuberculosis
Chiara Bellini, Kata Horváti
Cells, 2020
Drug conjugation induced modulation of structural and membrane interaction features of cationic cell-permeable peptides
Edit Pári, Kata Horváti, Szilvia Bősze, Beáta Biri-Kovács, Bálint Szeder, Ferenc Zsila, Éva Kiss
International Journal of Molecular Sciences, 2020
Anionic food color tartrazine enhances antibacterial efficacy of histatin-derived peptide DHVAR4 by fine-tuning its membrane activity
Maria Ricci, Kata Horváti, Tünde Juhász, Imola Szigyártó, György Török, Fanni Sebák, Andrea Bodor, László Homolya, Judit Henczkó, Bernadett Pályi, Tamás Mlinkó, Judith Mihály, Bilal Nizami, Zihuayuan Yang, Fengming Lin, Xiaolin Lu, Loránd Románszki, Attila Bóta, Zoltán Varga, Szilvia Bősze, Ferenc Zsila, Tamás Beke-Somfai
Quarterly Reviews of Biophysics, 2020
Galls of European Fraxinus trees as new and abundant sources of valuable phenylethanoid and coumarin glycosides
Moritz Zürn, Gergő Tóth, Márta Kraszni, Anna Sólyomváry, Zoltán Mucsi, Ruth Deme, Balázs Rózsa, Blanka Fodor, Ibolya Molnár-Perl, Kata Horváti, Szilvia Bősze, Bernadett Pályi, Zoltán Kis, Szabolcs Béni, Béla Noszál, Imre Boldizsár
Industrial Crops and Products, 2019
A convenient synthetic method to improve immunogenicity of mycobacterium tuberculosis related T-cell epitope peptides
Kata Horváti, Bernadett Pályi, Judit Henczkó, Gyula Balka, Eleonóra Szabó, Viktor Farkas, Beáta Biri-Kovács, Bálint Szeder, Kinga Fodor
Vaccines, 2019
Chemical structure and in vitro cellular uptake of luminescent carbon quantum dots prepared by solvothermal and microwave assisted techniques
Gergő Gyulai, Fatima Ouanzi, Imre Bertóti, Miklós Mohai, Tamás Kolonits, Kata Horváti, Szilvia Bősze
Journal of Colloid and Interface Science, 2019
Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 with the Polysulfonated Drug Suramin: A Step Closer to in Vivo Complexity
Mayra Quemé‐Peña, Tünde Juhász, Judith Mihály, Imola Cs. Szigyártó, Kata Horváti, Szilvia Bősze, Judit Henczkó, Bernadett Pályi, Csaba Németh, Zoltán Varga, Ferenc Zsila, Tamás Beke‐Somfai
Chembiochem, 2019
A road map for prioritizing warheads for cysteine targeting covalent inhibitors
Péter Ábrányi-Balogh, László Petri, Tímea Imre, Péter Szijj, Andrea Scarpino, Martina Hrast, Ana Mitrović, Urša Pečar Fonovič, Krisztina Németh, Hélène Barreteau, David I. Roper, Kata Horváti, György G. Ferenczy, Janko Kos, Janez Ilaš, Stanislav Gobec, György M. Keserű
European Journal of Medicinal Chemistry, 2018
Membrane affinity and fluorescent labelling: comparative study of monolayer interaction, cellular uptake and cytotoxicity profile of carboxyfluorescein-conjugated cationic peptides
Éva Kiss, Gergő Gyulai, Edit Pári, Kata Horváti, Szilvia Bősze
Amino Acids, 2018
Surface Layer Modification of Poly(d, l -lactic- co-glycolic acid) Nanoparticles with Targeting Peptide: A Convenient Synthetic Route for Pluronic F127-Tuftsin Conjugate
Kata Horváti, Gergő Gyulai, Antal Csámpai, János Rohonczy, Éva Kiss, Szilvia Bősze
Bioconjugate Chemistry, 2018
Hemin and bile pigments are the secondary structure regulators of intrinsically disordered antimicrobial peptides
Ferenc Zsila, Tünde Juhász, Szilvia Bősze, Kata Horváti, Tamás Beke‐Somfai
Chirality, 2018
Comparative analysis of internalisation, haemolytic, cytotoxic and antibacterial effect of membrane-active cationic peptides: aspects of experimental setup
Kata Horváti, Bernadett Bacsa, Tamás Mlinkó, Nóra Szabó, Ferenc Hudecz, Ferenc Zsila, Szilvia Bősze
Amino Acids, 2017
Drug and dye binding induced folding of the intrinsically disordered antimicrobial peptide CM15
Ferenc Zsila, Szilvia Bősze, Kata Horváti, Imola Cs. Szigyártó, Tamás Beke-Somfai
Rsc Advances, 2017
Comparative analysis of new peptide conjugates of antitubercular drug candidates—Model membrane and in vitro studies
Á. Ábrahám, Zs. Baranyai, G. Gyulai, E. Pári, K. Horváti, Sz. Bősze, É. Kiss
Colloids and Surfaces B Biointerfaces, 2016
Population tailored modification of tuberculosis specific interferon-gamma release assay
Kata Horvati, Szilvia Bősze, Hannah P. Gideon, Bernadett Bacsa, Tamás G. Szabó, Rene Goliath, Molebogeng X. Rangaka, Ferenc Hudecz, Robert J. Wilkinson, Katalin A. Wilkinson
Journal of Infection, 2016
Combating highly resistant emerging pathogen Mycobacterium abscessus and Mycobacterium tuberculosis with novel salicylanilide esters and carbamates
Zsuzsa Baranyai, Martin Krátký, Jarmila Vinšová, Nóra Szabó, Zsuzsanna Senoner, Kata Horváti, Jiřina Stolaříková, Sándor Dávid, Szilvia Bősze
European Journal of Medicinal Chemistry, 2015
Antimycobacterial activity of peptide conjugate of pyridopyrimidine derivative against Mycobacterium tuberculosis in a series of in vitro and in vivo models
Kata Horváti, Bernadett Bacsa, Nóra Szabó, Kinga Fodor, Gyula Balka, Miklós Rusvai, Éva Kiss, Gábor Mező, Vince Grolmusz, Beáta Vértessy, Ferenc Hudecz, Szilvia Bősze
Tuberculosis, 2015
Nanoparticle encapsulated lipopeptide conjugate of antitubercular drug isoniazid: In vitro intracellular activity and in vivo efficacy in a guinea pig model of tuberculosis
Kata Horváti, Bernadett Bacsa, Éva Kiss, Gergő Gyulai, Kinga Fodor, Gyula Balka, Miklós Rusvai, Eleonóra Szabó, Ferenc Hudecz, Szilvia Bősze
Bioconjugate Chemistry, 2014
Tuneable surface modification of PLGA nanoparticles carrying new antitubercular drug candidate
É. Kiss, G. Gyulai, Cs. B. Pénzes, M. Idei, K. Horváti, B. Bacsa, Sz. Bősze
Colloids and Surfaces A Physicochemical and Engineering Aspects, 2014
Fluorogenic tagging of peptides via Cys residues using thiol-specific vinyl sulfone affinity tags
Gergely B. Cserép, Zsuzsa Baranyai, Dávid Komáromy, Kata Horváti, Szilvia Bősze, Péter Kele
Tetrahedron, 2014
The role of citrullination of an immunodominant proteoglycan (PG) aggrecan T cell epitope in BALB/c mice with PG-induced arthritis
Petra Misják, Szilvia Bősze, Kata Horváti, Mária Pásztói, Krisztina Pálóczi, Marianna C. Holub, Ferenc Szakács, Borbála Aradi, Bence György, Tamás G. Szabó, György Nagy, Tibor T. Glant, Katalin Mikecz, András Falus, Edit I. Buzás
Immunology Letters, 2013
Membrane affinity of antituberculotic drug conjugate using lipid monolayer containing mycolic acid
Cs.B. Pénzes, D. Schnöller, K. Horváti, Sz. Bősze, G. Mező, É. Kiss
Colloids and Surfaces A Physicochemical and Engineering Aspects, 2012
Enhanced cellular uptake of a new, in silico identified antitubercular candidate by peptide conjugation
Kata Horváti, Bernadett Bacsa, Nóra Szabó, Sándor Dávid, Gábor Mező, Vince Grolmusz, Beáta Vértessy, Ferenc Hudecz, Szilvia Bősze
Bioconjugate Chemistry, 2012
Nanoencapsulation of antitubercular drug isoniazid and its lipopeptide conjugate
É. Kiss, D. Schnöller, K. Pribranská, K. Hill, Cs. B. Pénzes, K. Horváti, Sz. Bősze
Journal of Dispersion Science and Technology, 2011
New series of isoniazid hydrazones linked with electron-withdrawing substituents
Eva Vavříková, Slovenko Polanc, Marijan Kočevar, Janez Košmrlj, Kata Horváti, Szilvia Bősze, Jiřina Stolaříková, Aleš Imramovský, Jarmila Vinšová
European Journal of Medicinal Chemistry, 2011
New fluorine-containing hydrazones active against MDR-tuberculosis
Eva Vavříková, Slovenko Polanc, Marijan Kočevar, Kata Horváti, Szilvia Bősze, Jiřina Stolaříková, Kateřina Vávrová, Jarmila Vinšová
European Journal of Medicinal Chemistry, 2011
Cytotoxicity decreasing effect and antimycobacterial activity of chitosan conjugated with antituberculotic drugs
Eva Vavříková, Jana Mandíková, František Trejtnar, Kata Horváti, Szilvia Bösze, Jiřina Stolaříková, Jarmila Vinšová
Carbohydrate Polymers, 2011
New amino acid esters of salicylanilides active against MDR-TB and other microbes
Martin Krátký, Jarmila Vinšová, Vladimír Buchta, Kata Horvati, Szilvia Bösze, Jiřina Stolaříková
European Journal of Medicinal Chemistry, 2010
Membrane affinity of new antitubercular drug candidates using a phospholipid langmuir monolayer model and LB technique
D. Schnöller, Cs. B. Pénzes, K. Horváti, Sz. Bősze, F. Hudecz, É. Kiss
Progress in Colloid and Polymer Science, 2010
Synthesis and in vitro functional characterization of peptide conjugates that inhibit the growth of Mycobacterium tuberculosis H37Rv
European Cells and Materials, 2010
Characterisation of the membrane affinity of an isoniazide peptide conjugate by tensiometry, atomic force microscopy and sum-frequency vibrational spectroscopy, using a phospholipid Langmuir monolayer model
Katalin Hill, Csanád Botond Pénzes, Donát Schnöller, Kata Horváti, Szilvia Bősze, Ferenc Hudecz, Tamás Keszthelyi, Éva Kiss
Physical Chemistry Chemical Physics, 2010
Role of iron metabolism-regulator hepcidin in perinatal iron homeostasis
Ádám Balogh, Szilvia Bősze, Kata Horváti, Gábor Mező, Sándor Kéki, Lajos Nagy, Géza Bokodi, Miklós Szabó, Barna Vásárhelyi
Orvosi Hetilap, 2010
Peptide conjugates of therapeutically used antitubercular isoniazid - Design, synthesis and antimycobacterial effect
Kata Horváti, Gábhor Mező, Nóra Szabó, Ferenc Hudecz, Szilvia Bősze
Journal of Peptide Science, 2009
Synthesis of hepcidin derivatives in order to develop standards for immune adsorption method
Ádám Balogh, Kata Horváti, Gábor Mező, László Derzbach, Beáta Szebeni, Lajos Nagy, József Prechl, Barna Vásárhelyi, Ferenc Hudecz, Szilvia Bősze
Journal of Peptide Science, 2009
Solid-phase synthesis of difficult peptide sequences at elevated temperatures: A critical comparison of microwave and conventional heating technologies
Bernadett Bacsa, Kata Horváti, Szilvia Bõsze, Fritz Andreae, C. Oliver Kappe
Journal of Organic Chemistry, 2008
A simple method for monitoring the cysteine content in synthetic peptides
Kata Horváti, Szilvia Bõsze, Ferenc Hudecz, Hedvig Medzihradszky‐Schweiger
Journal of Peptide Science, 2008
Antibody recognition and conformational flexibility of a plaque-specific β-amyloid epitope modulated by non-native peptide flanking regions
Marilena Manea, Adrián Kalászi, Gábor Mező, Kata Horváti, Andrea Bodor, Anikó Horváth, Ödön Farkas, András Perczel, Michael Przybylski, Ferenc Hudecz
Journal of Medicinal Chemistry, 2008

Kata Horvati

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS