Caroline C Real
@pure.au.dk
Aarhus University
Scopus Publications
- Skeletal muscle alterations in Marfan syndrome: a systematic review
Audrei R. Santos, Rita M. S. Gutierrez, Tatiana E. Koike, Talita C. Conte, Caroline C. Real, Nicolas A. Dumont, Elen H. Miyabara
Journal of Muscle Research and Cell Motility, 2025 - Brain metabolic and behavioral alterations in a Down syndrome model
Larissa Estessi de Souza, Chiara Maria Righini, Dimitri Brigide de Almeida Mantovani, Manuella Penido Silva, Gabriela Lazzarotto, Christian Limberger, Carlos Alberto Buchpiguel, Eduardo Rigon Zimmer, Caroline Cristiano Real, Lidia Emmanuela Wiazowski Spelta, Daniele de Paula Faria
Nuclear Medicine and Biology, 2025 - The Role of Exercise on Glial Cell Activity in Neuropathic Pain Management
Willians Fernando Vieira, Caroline C. Real, Daniel Oliveira Martins, Marucia Chacur
Cells, 2025
Chronic pain is a widespread global health problem with profound socioeconomic implications, affecting millions of people of all ages. Glial cells (GCs) in pain pathways play essential roles in the processing of pain signals. Dysregulation of GC activity contributes to chronic pain states, making them targets for therapeutic interventions. Non-pharmacological approaches, such as exercise, are strongly recommended for effective pain management. This review examines the link between exercise, regular physical activity (PA), and glial cell-mediated pain processing, highlighting its potential as a strategy for managing chronic pain. Exercise not only improves overall health and quality of life but also influences the function of GCs. Recent research highlights the ability of exercise to mitigate neuroinflammatory responses and modulate the activity of GCs by reducing the activation of microglia and astrocytes, as well as modulating the expression biomarkers, thereby attenuating pain hypersensitivity. Here, we summarize new insights into the role of exercise as a non-pharmacological intervention for the relief of chronic pain. - Metabolic Differences in Neuroimaging with [18F]FDG in Rats Under Isoflurane and Hypnorm–Dormicum
Aage Kristian Olsen Alstrup, Mette Simonsen, Kim Vang Hansen, Caroline C. Real
Tomography, 2025
Background: Anesthesia can significantly impact positron emission tomography (PET) neuroimaging in preclinical studies. Therefore, understanding these effects is crucial for accurate interpretation of the results. In this experiment, we investigate the effect of [18F]-labeled glucose analog fluorodeoxyglucose ([18F]FDG) uptake in the brains of rats anesthetized with two commonly used anesthetics for rodents: isoflurane, an inhalation anesthetic, and Hypnorm–Dormicum, a combination injection anesthetic. Materials and Methods: Female adult Sprague Dawley rats were randomly assigned to one of two anesthesia groups: isoflurane or Hypnorm–Dormicum. The rats were submitted to dynamic [18F]FDG PET scan. The whole brain [18F]FDG standard uptake value (SUV) and the brain voxel-based analysis were performed. Results: The dynamic [18F]FDG data revealed that the brain SUV was 38% lower in the isoflurane group after 40 min of image (2.085 ± 0.3563 vs. 3.369 ± 0.5577, p = 0.0008). In voxel-based analysis between groups, the maps collaborate with SUV data, revealing a reduction in [18F]FDG uptake in the isoflurane group, primarily in the cortical regions, with additional small increases observed in the midbrain and cerebellum. Discussion and Conclusions: The observed differences in [18F]FDG uptake in the brain may be attributed to variations in metabolic activity. These results underscore the necessity for careful consideration of anesthetic choice and its impact on neuroimaging outcomes in future research. - Acute transcutaneous auricular vagus nerve stimulation modulates presynaptic SV2A density in healthy rat brain: An in vivo microPET study
Karina H. Binda, Caroline C. Real, Mette T. Simonsen, Ebbe K. Grove, Dirk Bender, Albert Gjedde, David J. Brooks, Anne M. Landau
Psychophysiology, 2025
Vagus nerve stimulation (VNS) is the subject of exploration as an adjunct treatment for neurological disorders such as epilepsy, chronic migraine, pain, and depression. A non‐invasive form of VNS is transcutaneous auricular VNS (taVNS). Combining animal models and positron emission tomography (PET) may lead to a better understanding of the elusive mechanisms of taVNS. We evaluated the acute effect of electrical stimulation of the left vagus nerve via the ear on brain synaptic vesicle glycoprotein 2A (SV2A) as a measure of presynaptic density and glucose metabolism in naïve rats. Female Sprague–Dawley rats were imaged with [11C]UCB‐J (n = 11) or [18F]fluorodeoxyglucose ([18F]FDG) PET (n = 13) on two separate days, (1) at baseline, and (2) after acute unilateral left taVNS or sham stimulation (30 min). We calculated the regional volume of distribution (VT) for [11C]UCB‐J and standard uptake values (SUV) for [18F]FDG. We observed regional reductions of [11C]UCB‐J binding in response to taVNS ranging from 36% to 59%. The changes in taVNS compared to baseline were significantly larger than those induced by sham stimulation. The differences were observed bilaterally in the frontal cortex, striatum, and midbrain. The [18F]FDG PET uptake remained unchanged following acute taVNS or sham stimulation compared to baseline values. This proof‐of‐concept study shows for the first time that acute taVNS for 30 min can modulate in vivo synaptic SV2A density in cortical and subcortical regions of healthy rats. Preclinical disease models and PET ligands of different targets can be a powerful combination to assess the therapeutic potential of taVNS. - Modulation of the endocannabinoid system by (S)-ketamine in an animal model of depression
Nicole R. Silva, Shokouh Arjmand, Luana B. Domingos, Adriano M. Chaves-Filho, Melina Mottin, Caroline C. Real, Anna L. Waszkiewicz, Pedro H. Gobira, Alessio Nicola Ferraro, Anne M. Landau, Carolina H. Andrade, Heidi K. Müller, Gregers Wegener, Sâmia R.L. Joca
Pharmacological Research, 2025
Ketamine (KET) is recognized as rapid-acting antidepressant, but its mechanisms of action remain elusive. Considering the role of endocannabinoids (eCB) in stress and depression, we investigated if S-KET antidepressant effects involve the regulation of the eCB system using an established rat model of depression based on selective breeding: the Flinders Sensitive Line (FSL) and their controls, the Flinders Resistant Line (FRL). S-KET (15 mg/kg) effects were assessed in rats exposed to the open field and forced swimming test (FST), followed by analysis of the eCB signaling in the rat prefrontal cortex (PFC), a brain region involved in depression neurobiology. Changes in eCB receptors and enzymes were assessed at mRNA and protein levels (qPCR and western blot), CB1 binding ([ 3 H]SR141716A autoradiography) and endocannabinoid content (lipidomics). The results demonstrated that the depressive behavior in FSL was negatively correlated with 2-AG levels, which were restored upon acute S-KET treatment. Although S-KET decreased CB1 and FAAH gene expression in FSL, there were no significant changes at protein levels. [ 3 H]SR141716A binding to CB1 receptors was increased by S-KET and in silico analysis suggested that it binds to CB1, CB2, GPR55 and FAAH. Overall, S-KET effects correlated with an increased endocannabinoid signaling in the PFC, but systemic treatment with rimonabant failed to block its behavioral effects. Altogether, our results indicate that S -KET facilitates eCB signaling in the PFC of FSL. The inability of rimonabant to block the antidepressant effect of S-KET highlights the complexity of its interaction with the ECS, warranting further investigation into the molecular pathways. • FSL rats, a well validated model of depression, presented decreased levels of 2-AG and other major endocannabinoids in the prefrontal cortex (PFC) • S-Ketamine induced rapid antidepressant effects in FSL and attenuated the deficits in 2-AG levels and increased CB1 in the PFC • The behavioral effect of S-Ketamine was associated with an overall upregulation of endocannabinid levels in the PFC • Computational analysis suggested that S-ketamine has a multitargeted action in the endocannabinoid system, which may contribute to its behavioral effects - Heterobivalent Dual-Target Peptide for Integrin-αvβ3 and Neuropeptide Y Receptors on Breast Tumor
Aryel H. Ferreira, Caroline C. Real, Osvaldo Malafaia
Pharmaceuticals, 2024
Background/Objectives: Heterodimer peptides targeting more than one receptor can be advantageous, as tumors can simultaneously express more than one receptor type. For human breast cancer, a promising biological target is tumor angiogenesis through αvβ3 integrin expression. Another promising target is Neuropeptide Y receptors, considering Y1R is overexpressed in 90% of human breast tumors. This article details the development and preclinical evaluation, both in vitro and in vivo, of a novel heterodimer peptide dual-receptor-targeting probe, [99mTc]HYNIC-cRGDfk-NPY, designed for imaging breast tumors. Methods: Female BALB/c healthy mice were used to perform biodistrubution studies and female SCID mice were subcutaneously injected with MCF-7 and MDA-MB-231 tumor cells. [99mTc]HYNIC-cRGDfk-NPY was intravenously administered to the mice, followed by ex vivo biodistribution studies and small-animal SPECT/CT imaging. Nonspecific tracer uptake in both models was determined by coinjecting an excess of unlabeled HYNIC-cRGDfk-NPY (100 µg) along with the radiolabeled tracer. Results: Imaging and biodistribution data demonstrate good uptake to estrogen receptor-positive (MCF-7) and triple-negative (MDA-MB-231) tumor models. The in vivo tumor uptakes of radiolabeled conjugate were 9.30 ± 3.25% and 4.93 ± 1.01% for MCF-7 and MDA-MB231, respectively. The tumor/muscle ratios were 5.65 ± 0.94 for the MCF-7 model and 7.78 ± 3.20 for MDA-MB231. Conclusions: [99mTc]HYNIC-cRGDfk-NPY demonstrated rapid blood clearance, renal excretion, and in vivo tumor uptake, highlighting its potential as a tumor imaging agent. - Immunotherapeutic potential of collagen V oral administration in mBSA/CFA-induced arthritis
Lizandre Keren Ramos da Silveira, Ana Paula P. Velosa, Sergio Catanozi, Marco Aurélio A. Pereira, Antonio dos Santos Filho, Fabio Luiz N. Marques, Daniele de Paula Faria, Caroline Cristiano Real, Sandra de M. Fernezlian, Amanda Flores Yanke, Zelita Aparecida de J. Queiroz, Vitória Elias Contini, Thays de Matos Lobo, Solange Carrasco, Camila Machado Baldavira, Cláudia Goldenstein-Schainberg, Ricardo Fuller, Vera L. Capelozzi, Walcy R. Teodoro
Plos One, 2024
We hypothesized that after synovial injury, collagen V (Col V) expose occult antigens, and Col V autoantibodies develop, indicating the loss of immune tolerance against this molecule, thus leading to damage to mesenchymal-derived cells as well as the extracellular matrix in experimental arthritis. Thus, the present study investigated the effects of oral administration of Col V on the synovium after the development of inflammation in mBSA/CFA-induced arthritis. After fourteen days of intraarticular administration of mBSA, 10 male Lewis rats were orally administered Col V (500 μg/300 μL) diluted in 0.01 N acetic acid (IA-Col V group). The arthritic group (IA group, n = 10) received only intraarticular mBSA. An intra-articular saline injection (20 μL) was given to the control group (CT-Col V, n = 5). IA group presented damaged synovia, the expansion of the extracellular matrix by cellular infiltrate, which was characterized by T and B lymphocytes, and fibroblastic infiltration. In contrast, after Col V oral immunotherapy IA-Col V group showed a significant reduction in synovial inflammation and intense expression of IL-10+ and FoxP3+ cells, in addition to a reduction in Col V and an increase in Col I in the synovia compared to those in the IA group. Furthermore, an increase in IL-10 production was detected after IA-Col V group spleen cell stimulation with Col V in vitro. PET imaging did not differ between the groups. The evaluation of oral treatment with Col V, after mBSA/CFA-induced arthritis in rats, protects against inflammation and reduces synovial tissue damage, through modulation of the synovial matrix, showing an immunotherapeutic potential in inhibiting synovitis. - Glucocorticoid modulates oxidative and thermogenic function of rat brown adipose tissue and human brown adipocytes
Anaysa Paola Bolin, Flaviane de Fatima Silva, Rafael Barrera Salgueiro, Bruna Araújo dos Santos, Ayumi Cristina Medeiros Komino, Sandra Andreotti, Érica de Sousa, Érique de Castro, Caroline Cristiano Real, Daniele de Paula Faria, Gerson Profeta Souza, Henrique Camara, Carlos Arterio Sorgi, Yu‐Hua Tseng, Fábio Bessa Lima, Alice Cristina Rodrigues
Journal of Cellular Physiology, 2024
Chronic and excessive glucocorticoid (GC) exposure can cause Cushing's syndrome, resulting in fat accumulation in selected body areas. Particularly in the brown adipose tissue (BAT), GC acts negatively, resulting in whitening of the tissue. We hypothesized that dysregulation of microRNAs by GC could be an additional mechanism to explain its negative actions in BAT. Male Wistar rats were divided into two groups: (1) Control sham and (2) GC group that was administered dexamethasone 6.25 mg/200 μL via osmotic pump implantation over 28 days. After this period, the animals were euthanized and BAT tissue was properly stored. Human fat cells treated with dexamethasone were used to translate the experimental results found in animals to human biology. GC‐treated rat BAT presented with large lipid droplets, severely impaired thermogenic activation, and reduced glucose uptake measured by 18F‐FDG PET/CT. GC exposure induced a reduction in the mitochondrial OXPHOS system and oxygen consumption. MicroRNA profiling of BAT revealed five top‐regulated microRNAs and among them miR‐21‐5p was the most significantly upregulated in GC‐treated rats compared to the control group. Although upregulation of miR‐21‐5p in the tissue, differentiated primary brown adipocytes from GC‐treated rats had decreased miR‐21‐5p levels compared to the control group. To translate these results to the clinic, human brown adipocytes were treated with dexamethasone and miR‐21‐5p inhibitor. In human brown cells, inhibition of miR‐21‐5p increased brown adipocyte differentiation and prevented GC‐induced glucose uptake, resulting in a lower glycolysis rate. In conclusion, high‐dose GC therapy significantly impacts brown adipose tissue function, with a notable association between glucose uptake and miR‐21‐5p. - A single dose of cocaine raises SV2A density in hippocampus of adolescent rats
Rachele Rossi, Simone Larsen Bærentzen, Majken B. Thomsen, Caroline C. Real, Gregers Wegener, Rodrigo Grassi-Oliveira, Albert Gjedde, Anne M. Landau
Acta Neuropsychiatrica, 2024
ObjectiveCocaine is a highly addictive psychostimulant that affects synaptic activity with structural and functional adaptations of neurons. The transmembrane synaptic vesicle glycoprotein 2A (SV2A) of pre-synaptic vesicles is commonly used to measure synaptic density, as a novel approach to the detection of synaptic changes. We do not know if a single dose of cocaine suffices to affect pre-synaptic SV2A density, especially during adolescence when synapses undergo intense maturation. Here, we explored potential changes of pre-synaptic SV2A density in target brain areas associated with the cocaine-induced boost of dopaminergic neurotransmission, specifically testing if the effects would last after the return of dopamine levels to baseline.Methods:We administered cocaine (20 mg/kg i.p.) or saline to rats in early adolescence, tested their activity levels and removed the brains 1 hour and 7 days after injection. To evaluate immediate and lasting effects, we did autoradiography with [3H]UCB-J, a specific tracer for SV2A, in medial prefrontal cortex, striatum, nucleus accumbens, amygdala, and dorsal and ventral areas of hippocampus. We also measured the striatal binding of [3H]GBR-12935 to test cocaine’s occupancy of the dopamine transporter at both times of study.Results:We found a significant increase of [3H]UCB-J binding in the dorsal and ventral sections of hippocampus 7 days after the cocaine administration compared to saline-injected rats, but no differences 1 hour after the injection. The [3H]GBR-12935 binding remained unchanged at both times.Conclusion:Cocaine provoked lasting changes of hippocampal synaptic SV2A density after a single exposure during adolescence - Impact of cannabidiol on brain glucose metabolism of C57Bl/6 male mice previously exposed to cocaine
Lidia Emmanuela Wiazowski Spelta, Caroline Cristiano Real, Vitor Bruno, Carlos Alberto Buchpiguel, Raphael Caio Tamborelli Garcia, Larissa Helena Torres, Daniele de Paula Faria, Tania Marcourakis
Journal of Neuroscience Research, 2024 - Sex-specific regulation of miR-22 and ERα in white adipose tissue of obese dam's female offspring impairs the early postnatal development of functional beige adipocytes in mice
Érica de Sousa, Mariana de Mendonça, Anaysa Paola Bolin, Nayara Preste de Oliveira, Caroline Cristiano Real, Xiaoyun Hu, Zhan-Peng Huang, Da-Zhi Wang, Alice Cristina Rodrigues
Biochimica Et Biophysica Acta Molecular Basis of Disease, 2024 - Green Nanotechnology Through Papain Nanoparticles: Preclinical in vitro and in vivo Evaluation of Imaging Triple-Negative Breast Tumors
Aryel Ferreira, Fábio Marques, Caroline Real, Velaphi Thipe, Lucas Freitas, Caroline Lima, Larissa de Souza, Mara Junqueira, Daniele de Paula Faria, Gustavo Varca, Ademar Lugão, Kattesh Katti
Nanotechnology Science and Applications, 2024 - Mitigating jaw osteonecrosis: bioactive glass and pericardial membrane combination in a rat model
Alexandre Antonio Pellicano, Bernar M. Benites, Amanda F. N. Paschoa, Laura C. Oliveira, Ana Carolina P. Campos, Daniel O. Martins, Caroline C. Real, Daniele de Paula Faria, Felipe P. Fonseca, Raquel R. C. Martinez, Rosana L. Pagano, Eduardo R. Fregnani
Frontiers in Oncology, 2024 - Treadmill exercise modulates nigral and hippocampal cannabinoid receptor type 1 in the 6-OHDA model of Parkinson's disease
Karina Henrique Binda, Anne M Landau, Marucia Chacur, David J Brooks, Caroline Cristiano Real
Brain Research, 2023 - [18F]FDG and [11C]PK11195 PET imaging in the evaluation of brown adipose tissue - effects of cold and pharmacological stimuli and their association with crotamine intake in a male mouse model
Daniele de Paula Faria, Joana D'Arc Campeiro, Mara de Souza Junqueira, Caroline Cristiano Real, Fabio Luiz Navarro Marques, Mirian Akemi Furuie Hayashi, Marcelo Tatit Sapienza
Nuclear Medicine and Biology, 2023 - Exercise and Parkinson’s disease: Linking in the cannabinoid type 1 (CB1) and type 2 (CB2) and mu-opioid receptors
Marucia Chacur, Karina Henrique Binda, Caroline C Real
Neurobiology and Physiology of the Endocannabinoid System, 2023 - Selecting the best animal model of parkinson’s disease for your research purpose: Insight from in vivo pet imaging studies
Caroline Cristiano Real, Karina Henrique Binda, Majken Borup Thomsen, Thea Pinholt Lillethorup, David James Brooks, Anne Marlene Landau
Current Neuropharmacology, 2023 - Potential of [11C](R)-PK11195 PET Imaging for Evaluating Tumor Inflammation: A Murine Mammary Tumor Model
Aline Morais de Souza, Caroline Cristiano Real, Mara de Souza Junqueira, Larissa Estessi de Souza, Fábio Luiz Navarro Marques, Carlos Alberto Buchpiguel, Roger Chammas, Marcelo Tatit Sapienza, Daniele de Paula Faria
Pharmaceutics, 2022 - [18F]FDG brain uptake of C57Bl/6 male mice is affected by locomotor activity after cocaine use: A small animal positron emission tomography study
Lidia Emmanuela Wiazowski Spelta, Caroline Cristiano Real, Carlos Alberto Buchpiguel, Daniele de Paula Faria, Tania Marcourakis
Journal of Neuroscience Research, 2022 - Spontaneous partial recovery of striatal dopaminergic uptake despite nigral cell loss in asymptomatic MPTP-lesioned female minipigs
Thea P. Lillethorup, Ove Noer, Aage Kristian Olsen Alstrup, Caroline C. Real, Kathrine Stokholm, Majken Borup Thomsen, Hamed Zaer, Dariusz Orlowski, Trine Werenberg Mikkelsen, Andreas N. Glud, Erik Holm Toustrup Nielsen, Anna C. Schacht, Michael Winterdahl, David J. Brooks, Jens Christian H. Sørensen, Anne M. Landau
Neurotoxicology, 2022 - Cannabidiol Treatment Improves Glucose Metabolism and Memory in Streptozotocin-Induced Alzheimer’s Disease Rat Model: A Proof-of-Concept Study
Daniele de Paula Faria, Larissa Estessi de Souza, Fabio Luis de Souza Duran, Carlos Alberto Buchpiguel, Luiz Roberto Britto, José Alexandre de Souza Crippa, Geraldo Busatto Filho, Caroline Cristiano Real
International Journal of Molecular Sciences, 2022 - The effects of treadmill exercise in animal models of Parkinson's disease: A systematic review
Ana Flávia F. Ferreira, Karina Henrique Binda, Caroline Cristiano Real
Neuroscience and Biobehavioral Reviews, 2021 - 11C-PK11195 plasma metabolization has the same rate in multiple sclerosis patients and healthy controls: A cross-sectional study
Daniele de Paula Faria, AlineMorais de Souza, MilenaSales Pitombeira, LarissaEstessi de Souza, FabioLuiz Navarro Marques, CarlosAlberto Buchpiguel, CarolineCristiano Real
Neural Regeneration Research, 2021 - Neuroplasticity induced by the retention period of a complex motor skill learning in rats
Adaneuda Silva Britto Sampaio, Caroline Cristiano Real, Rita Mara Soares Gutierrez, Monique Patricio Singulani, Sandra Regina Alouche, Luiz Roberto Britto, Raquel Simoni Pires
Behavioural Brain Research, 2021 - Exercise protects synaptic density in a rat model of Parkinson's disease
K.H. Binda, T.P. Lillethorup, C.C. Real, S.L. Bærentzen, M.N. Nielsen, D. Orlowski, D.J. Brooks, M. Chacur, A.M. Landau
Experimental Neurology, 2021 - miRNA-22 deletion limits white adipose expansion and activates brown fat to attenuate high-fat diet-induced fat mass accumulation
Vanessa M. Lima, Jianming Liu, Bruna B. Brandão, Caroline A. Lino, Camila S. Balbino Silva, Márcio A.C. Ribeiro, Tiago E. Oliveira, Caroline C. Real, Daniele de Paula Faria, Carly Cederquist, Zhan-Peng Huang, Xiaoyun Hu, Maria Luiza Barreto-Chaves, Julio C.B. Ferreira, William T. Festuccia, Marcelo A. Mori, C. Ronald Kahn, Da-Zhi Wang, Gabriela P. Diniz
Metabolism Clinical and Experimental, 2021 - Development of a platform for the production of multiple modal chelating and imaging agents using desferrioxamine and bovine albumin as a model
Lucas Antonio Arias Correia, Rodrigo Santos Garcia, Caroline Cristiano Real, Daniel Henrique Uzueli, Ulisses Lacerda de Figueiredo Sá, Fabio Luiz Navarro Marques, Luiz Alberto Colnago, Breno Pannia Espósito
Chemical Papers, 2021 - Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
Daniele de Paula Faria, Caroline Cristiano Real, Larissa Estessi de Souza, Alexandre Teles Garcez, Fabio Luis Navarro Marques, Carlos Alberto Buchpiguel
Journal of Visualized Experiments Jove, 2021 - Positron emission tomography imaging for in vivo measuring of myelin content in the lysolecithin rat model of multiple sclerosis
Daniele de Paula Faria, Caroline Cristiano Real, Larissa Estessi de Souza, Alexandre Teles Garcez, Fabio Luis Navarro Marques, Carlos Alberto Buchpiguel
Journal of Visualized Experiments, 2021 - Local administration of stem cell-derived extracellular vesicles in a thermoresponsive hydrogel promotes a pro-healing effect in a rat model of colo-cutaneous post-surgical fistula
Arthur Berger, Irami Araújo-Filho, Max Piffoux, Alba Nicolás-Boluda, Alice Grangier, Imane Boucenna, Caroline Cristiano Real, Fabio Luiz Navarro Marques, Daniele de Paula Faria, Amália Cinthia Meneses do Rego, Chloe Broudin, Florence Gazeau, Claire Wilhelm, Olivier Clément, Christophe Cellier, Carlos Alberto Buchpiguel, Gabriel Rahmi, Amanda K. A. Silva
Nanoscale, 2021 - Treadmill exercise and neuroinflammation: Links with aging
Caroline Cristiano Real, Karina Henrique Binda, Anne Marlene Landau
Factors Affecting Neurological Aging Genetics Neurology Behavior and Diet, 2021 - Active lifestyle enhances protein expression profile in subjects with lewy body pathology
Caroline Cristiano Real, Cláudia Kimie Suemoto, Karina Henrique Binda, Lea Tenenholz Grinberg, Carlos Augusto Pasqualucci, Wilson Jacob Filho, Renata Eloah de Lucena Ferretti-Rebustini, Ricardo Nitrini, Renata Elaine Paraizo Leite, Luiz Roberto de Britto
Dementia E Neuropsychologia, 2021 - Physical exercise protects against mitochondria alterations in the 6-hidroxydopamine rat model of Parkinson's disease
Ana Flávia Fernandes Ferreira, Karina Henrique Binda, Monique Patricio Singulani, Carolina Parga Martins Pereira, Gustavo Duarte Ferrari, Luciane Carla Alberici, Caroline Cristiano Real, Luiz Roberto Britto
Behavioural Brain Research, 2020 - Therapeutic efficiency of multiple applications of magnetic hyperthermia technique in glioblastoma using aminosilane coated iron oxide nanoparticles: In vitro and in vivo study
Gabriel Rego, Mariana Nucci, Javier Mamani, Fernando Oliveira, Luciana Marti, Igor Filgueiras, João Ferreira, Caroline Real, Daniele Faria, Paloma Espinha, Daianne Fantacini, Lucas Souza, Dimas Covas, Carlos Buchpiguel, Lionel Gamarra
International Journal of Molecular Sciences, 2020 - Environmental Tobacco Smoke During the Early Postnatal Period of Mice Interferes With Brain 18 F-FDG Uptake From Infancy to Early Adulthood – A Longitudinal Study
Larissa Helena Torres, Caroline Cristiano Real, Walter Miguel Turato, Lídia Wiazowski Spelta, Ana Carolina Cardoso dos Santos Durão, Tatiana Costa Andrioli, Lorena Pozzo, Peterson Lima Squair, Marco Pistis, Daniele de Paula Faria, Tania Marcourakis
Frontiers in Neuroscience, 2020 - Antinociceptive effects of treadmill exercise in a rat model of Parkinson's disease: The role of cannabinoid and opioid receptors
K.H. Binda, C.C. Real, A.F.F. Ferreira, L.R. Britto, M. Chacur
Brain Research, 2020 - [11C]PIB PET imaging can detect white and grey matter demyelination in a non-human primate model of progressive multiple sclerosis
Robert H.F. Carvalho, Caroline C. Real, Simone Cinini, Alexandre T. Garcez, Fabio L.S. Duran, Fabio L.N. Marques, Luiz Eugênio Mello, Geraldo Busatto Filho, Erik F.J. de Vries, Luiz R.G. de Britto, Carlos A. Buchpiguel, Daniele de Paula Faria
Multiple Sclerosis and Related Disorders, 2019 - Endogenous protection against the 6-OHDA model of Parkinson's disease in the Amazonian rodent Proechimys
Marcia Jonathas Guimarães Marques, Caroline Cristiano Real, Daniella Balduino Victorino, Luiz Roberto Britto, Esper Abrão Cavalheiro, Fulvio Alexandre Scorza, Henrique Ballalai Ferraz, Carla Alessandra Scorza
Neuroscience Letters, 2019 - Evaluation of exercise-induced modulation of glial activation and dopaminergic damage in a rat model of Parkinson’s disease using [11C]PBR28 and [18F]FDOPA PET
Caroline C Real, Janine Doorduin, Paula Kopschina Feltes, David Vállez García, Daniele de Paula Faria, Luiz R Britto, Erik FJ de Vries
Journal of Cerebral Blood Flow and Metabolism, 2019 - Therapeutic effects of dietary intervention on neuroinflammation and brain metabolism in a rat model of photothrombotic stroke
Ewelina Kurtys, Cindy Casteels, Caroline C. Real, Ulrich L. M. Eisel, J. Martin Verkuyl, Laus M. Broersen, Hans C. Klein, Rudi A. J. O. Dierckx, Janine Doorduin, Erik F. J. de Vries
CNS Neuroscience and Therapeutics, 2019 - Motor improvement requires an increase in presynaptic protein expression and depends on exercise type and age
Rita Mara Soares Gutierrez, Caroline Cristiano Real, Catharine Ranieri Scaranzi, Priscila Crespo Garcia, Dalton Lustosa Oliveira, Luiz Roberto Britto, Raquel Simoni Pires
Experimental Gerontology, 2018 - Treadmill Exercise Prevents Increase of Neuroinflammation Markers Involved in the Dopaminergic Damage of the 6-OHDA Parkinson’s Disease Model
Caroline Cristiano Real, Priscila Crespo Garcia, Luiz R. G. Britto
Journal of Molecular Neuroscience, 2017 - Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model
L.M. Dati, H. Ulrich, C.C. Real, Z.P. Feng, H.S. Sun, L.R. Britto
Neuroscience, 2017 - The Impact of Short and Long-Term Exercise on the Expression of Arc and AMPARs During Evolution of the 6-Hydroxy-Dopamine Animal Model of Parkinson’s Disease
P. C. Garcia, C.C. Real, L.R. Britto
Journal of Molecular Neuroscience, 2017 - Distinct neuroplasticity processes are induced by different periods of acrobatic exercise training
Samira Salame, Priscila C. Garcia, Caroline C. Real, Juliana Borborema, Sandra R. Mota-Ortiz, Luiz R.G. Britto, Raquel S. Pires
Behavioural Brain Research, 2016 - Different protocols of treadmill exercise induce distinct neuroplastic effects in rat brain motor areas
Caroline C. Real, Priscila C. Garcia, Luiz R.G. Britto, Raquel S. Pires
Brain Research, 2015 - Temporal Changes of CB1 Cannabinoid Receptor in the Basal Ganglia as a Possible Structure-Specific Plasticity Process in 6-OHDA Lesioned Rats
Gabriela P. Chaves-Kirsten, Caio H. Y. Mazucanti, Caroline C. Real, Bruna M. Souza, Luiz R. G. Britto, Andréa S. Torrão
Plos One, 2013 - Corrigendum to "BDNF receptor blockade hinders the beneficial effects of exercise in a rat model of Parkinson's disease" [Neuroscience 237 (2013) 118-129]
C.C. Real, A.F.B. Ferreira, G.P. Chaves-Kirsten, A.S. Torrão, R.S. Pires, L.R.G. Britto
Neuroscience, 2013 - BDNF receptor blockade hinders the beneficial effects of exercise in a rat model of Parkinson's disease
C.C. Real, A.F.B. Ferreira, G.P. Chaves-Kirsten, A.S. Torrão, R.S. Pires, L.R.G. Britto
Neuroscience, 2013 - Different protocols of physical exercise produce different effects on synaptic and structural proteins in motor areas of the rat brain
Priscila C. Garcia, Caroline C. Real, Ana F.B. Ferreira, Sandra R. Alouche, Luiz R.G. Britto, Raquel S. Pires
Brain Research, 2012 - Different approaches, one target: Understanding cellular mechanisms of Parkinson's and Alzheimer's diseases
Andréa S. Torrão, Cecilia C. Café-Mendes, Caroline C. Real, Marina S. Hernandes, Ana F.B. Ferreira, Taisa O. Santos, Gabriela P. Chaves-Kirsten, Caio H.Y. Mazucanti, Emer S. Ferro, Cristoforo Scavone, Luiz R.G. Britto
Revista Brasileira De Psiquiatria, 2012 - Short-term, moderate exercise is capable of inducing structural, bdnf-independent hippocampal plasticity
Ana F.B. Ferreira, Caroline C. Real, Alice C. Rodrigues, Adilson S. Alves, Luiz R.G. Britto
Brain Research, 2011 - Exercise-induced plasticity of AMPA-type glutamate receptor subunits in the rat brain
Caroline C. Real, Ana F.B. Ferreira, Marina S. Hernandes, Luiz R.G. Britto, Raquel S. Pires
Brain Research, 2010 - Moderate exercise changes synaptic and cytoskeletal proteins in motor regions of the rat brain
Ana F.B. Ferreira, Caroline C. Real, Alice C. Rodrigues, Adilson S. Alves, Luiz R.G. Britto
Brain Research, 2010 - Reactive oxygen species and the structural remodeling of the visual system after ocular enucleation
M.S. Hernandes, L.R.G. Britto, C.C. Real, D.O. Martins, L.R. Lopes
Neuroscience, 2010 - Differential response of AMPA and NMDA glutamate receptors of Purkinje cells to aging of the chicken cerebellum
Raquel S. Pires, Caroline C. Real, Thiago S. Folador, Nataly R. Tellini, Andréa S. Torrão, Luiz R.G. Britto
Neuroscience Letters, 2010 - Ontogeny of subunits 2 and 3 of the AMPA-type glutamate receptors in Purkinje cells of the developing chick cerebellum
Raquel S. Pires, Caroline C. Real, Mirian A.F. Hayashi, Luiz R.G. Britto
Brain Research, 2006
