Stefano Gobbo

Scopus Publications

Development of a deep learning-based tool for coronary artery stenosis evaluation in forensic autopsies using whole slide imaging
Nicola Pigaiani, Shakiba Sharifi, Marianna Garavello, Francesco Setti, Francesco Ausania, Federica Bortolotti, Alberto Chighine, Ernesto D’Aloja, Pamela Rodegher, Serena Ammendola, Matteo Brunelli, Marco Cristani, Stefano Gobbo
International Journal of Legal Medicine, 2026
BACKGROUND: Cardiovascular disease is a leading cause of mortality, with coronary artery disease accounting for over 60% of cases in adults. Accurate quantification of coronary stenosis in forensic autopsies is crucial for determining causality between pathological findings and death, but is hindered by subjective visual assessments and inter-observer variability. This study aimed to develop an AI-driven tool using whole-slide images for objective stenosis measurement in forensic investigations. MATERIALS AND METHODS: From 98 anonymized H&E-stained autopsy slides (234 coronary sections), 103 high-quality regions of interest were selected and split into training (n = 82), validation (n = 14), and test (n = 7) datasets. Annotations delineated lumen, internal elastic lamina, and external elastic lamina using QuPath. A SegFormer-B0 transformer model was trained with data augmentation, weighted cross-entropy loss, and AdamW optimization. Post-processing enforced anatomical structural hierarchy and generated hybrid confidence maps. RESULTS: On validation dataset, agreement with ground truth was excellent (MAE 3.22% points; RMSE 4.00; MAPE 6.07%; r = 0.986; ICC = 0.986), with slight underestimation. Bland–Altman bias was − 1.36 pp (95% LoA − 9.01 to 6.28 pp), indicating performance across severities. On the test set, accuracy improved (MAE 1.01 pp; RMSE 1.50; MAPE 2.11%; r = 0.998; ICC = 0.995) and outperformed three pathologists’ visual estimates (MAE 16.11, 8.18, 4.79 pp). Bland–Altman bias for the model was − 0.82 pp with tight limits of agreement (− 3.48 to 1.83 pp). Total inference time was 199.08 s for seven cases (28.44 s/image). CONCLUSIONS: WSI-based transformer pipeline enables rapid, auditable, and reproducible coronary stenosis measurement, reducing inter-observer variability and supporting standardized interpretation in forensic investigations.
The evolution of prostate cancer grading: from Gleason score to risk taxonomy and the artificial intelligence revolution
Enrico Munari, Pietro Antonini, Luca Cima, Rita Polati, Anna Caliò, Stefano Tinazzi Martini Gobbo, Maurizio Colecchia, George J. Netto, Alessandro Antonelli, Riccardo G. Bertolo, Clément Grisi, Geert Litjens, Matteo Brunelli
Virchows Archiv, 2026
AIDA: AI-Driven Intelligent Diagnostics and Analytics
Zanxi Ruan, Stefano Gobbo, Luca Cima, Mattia Mondo, Shakiba Sharifi, Enrico Munari, Aldo Scarpa, Omar Shahbaz Khan, Stefán Ólafsson, Andrea Giachetti, Francesco Setti, Yiming Wang, Björn Þór Jónsson, Marco Cristani
Lecture Notes in Computer Science, 2026
Galileo—an Artificial Intelligence tool for evaluating pre-implantation kidney biopsies
Albino Eccher, Vincenzo L’Imperio, Liron Pantanowitz, Giorgio Cazzaniga, Fabio Del Carro, Stefano Marletta, Giovanni Gambaro, Antonella Barreca, Jan Ulrich Becker, Stefano Gobbo, Vincenzo Della Mea, Federico Alberici, Fabio Pagni, Angelo Paolo Dei Tos
Journal of Nephrology, 2025
Background Pre-transplant procurement biopsy interpretation is challenging, also because of the low number of renal pathology experts. Artificial intelligence (AI) can assist by aiding pathologists with kidney donor biopsy assessment. Herein we present the “Galileo” AI tool, designed specifically to assist the on-call pathologist with interpreting pre-implantation kidney biopsies. Methods A multicenter cohort of whole slide images acquired from core-needle and wedge biopsies of the kidney was collected. A deep learning algorithm was trained to detect the main findings evaluated in the pre-implantation setting (normal glomeruli, globally sclerosed glomeruli, ischemic glomeruli, arterioles and arteries). The model obtained on the Aiforia Create platform was validated on an external dataset by three independent pathologists to evaluate the performance of the algorithm. Results Galileo demonstrated a precision, sensitivity, F1 score and total area error of 81.96%, 94.39%, 87.74%, 2.81% and 74.05%, 71.03%, 72.5%, 2% in the training and validation sets, respectively. Galileo was significantly faster than pathologists, requiring 2 min overall in the validation phase (vs 25, 22 and 31 min by 3 separate human readers, p < 0.001). Galileo-assisted detection of renal structures and quantitative information was directly integrated in the final report. Conclusions The Galileo AI-assisted tool shows promise in speeding up pre-implantation kidney biopsy interpretation, as well as in reducing inter-observer variability. This tool may represent a starting point for further improvements based on hard endpoints such as graft survival. Graphical Abstract
iForensic, multicentric validation of digital whole slide images (WSI) in forensic histopathology setting according to the College of American Pathologists guidelines
Nicola Pigaiani, Antonio Oliva, Vito Cirielli, Simone Grassi, Vincenzo Arena, Luca-Maria Solari, Naomi Tatriele, Dario Raniero, Matteo Brunelli, Stefano Gobbo, Aldo Scarpa, Liron Pantanowitz, Pamela Rodegher, Federica Bortolotti, Francesco Ausania
International Journal of Legal Medicine, 2025
Pathology has benefited from the rapid progress of image-digitizing technology during the last decade. However, the application of digital whole slide images (WSI) in forensic pathology still needs to be improved. WSI validation is crucial to ensure diagnostic performance, at least equivalent to glass slides and light microscopy. The College of American Pathologists Pathology and Laboratory Quality Center recently updated internal digital pathology system validation recommendations. Following these guidelines, this pilot study aimed to validate the performance of a digital approach for forensic histopathological diagnosis. Six independent skilled forensic pathologists from different forensic medicine institutes evaluated 100 glass slides of forensic interest (80 stained with standard hematoxylin and eosin, 20 with special staining), including different organs and tissues, with light microscopy (Olympus BX51, Tokyo, Japan). Glass slides were scanned using the Aperio GT 450 DX Digital Slides Scanner (Leica Biosystems, Nussloch, Germany). After two wash-out weeks, forensic pathologists evaluated WSIs in front of a widescreen using computer devices with dedicated software (O3 viewer, O3 Enterprise, Zucchetti, Trieste, Italy). Side-by-side comparisons between diagnoses performed on tissue glass slides versus WSIs were above the threshold stated in the validation guidelines (mean concordance of 97.8%). CSUQ Version 3 questionnaire showed high satisfaction for all pathologists (mean result: 6.6/7). Our institutional digital forensic pathology system has been validated for practical casework application. This approach opens new scenarios in practical forensic casework investigations, such as sharing live histological ex-glass slides online, as well as educational and research perspectives, with improving impacts on the whole daily workflow.
Forensic value of soft tissue detachments from the hyoid bone in death due to strangulation asphyxia
Giovanna Del Balzo, Guido Pelletti, Dario Raniero, Alessia Farinelli, Andrea Uberti, Elisa Vermiglio, Gabriele Molteni, Riccardo Nocini, Stefano Gobbo, Francesco Taus, Albino Eccher, Claudio Lucchini, Matteo Brunelli
Advances in Clinical and Experimental Medicine, 2025
BACKGROUND There are no unequivocal histopathological findings for the diagnosis of fatal asphyxia due to neck compression. From the observation of a series of asphyxiation cases, we noted, during microscopic analysis, a high frequency of "detachment" of soft tissues from the hyoid bone. This specifically refers to the presence of an optical space between the surface of the hyoid bone and soft tissues. OBJECTIVES We aimed to evaluate the detachment of soft tissues from the hyoid bone as specific histological evidence of death due to strangulation asphyxia. MATERIAL AND METHODS Ten blocks were taken from deaths due to external mechanical compression of the neck (strangulation asphyxia, group A), 22 blocks were taken from deaths for other causes without trauma to the neck (group B), and 38 blocks were obtained from living subjects that have undergone laryngectomies (group C). The presence/absence of detachments were compared between the 3 groups (A, B and C) using Fisher's exact test. RESULTS The detachment of soft tissues from the hyoid bone was observed in 5 cases (50%) in group A, 6 cases (27.2%) in group B, and 17 cases (44.3%) in group C. The sensitivity and specificity of the presence of the detachment in group A were 0.5 (95% confidence interval (95% CI): 0.38-0.62) and 0.57 (95% CI: 0.45-0.69), respectively. The comparison between the 3 groups and the presence/absence of soft tissue detachment showed no statistically significant differences between the groups (p = 0.329), clarifying that soft tissue detachment is a nonspecific variable for all 3 situations. CONCLUSIONS Detachment of soft tissues has poor value as a single element to favor the diagnosis of asphyxia due to violent compression of the neck and should be interpreted as an artifactual finding, unrelated to the neck injury or injury vitality.
Giant cell inflammatory reaction to hemostatic cellulose matrix mimicking renal cell carcinoma recurrence
Riccardo BERTOLO, Francesco CIANFLONE, Riccardo NEGRELLI, Giovanni CORGHI, Michele BOLDINI, Francesco DITONNO, Luca ROGGERO, Antonio B. PORCARO, Alessandro VECCIA, Elena MARASTONI, Stefano GOBBO, Matteo BRUNELLI, Mirko D’ONOFRIO, Alessandro ANTONELLI
Minerva Urology and Nephrology, 2025
Atypical suicide by single incising cut to the throat without hesitation marks: Case report and review of the literature
V. Cirielli, G. Cecchetto, M. Narayanasamy, A. Eccher, S. Gobbo, M. Brunelli, N. Pigaiani
Legal Medicine, 2024
Artificial intelligence-based algorithms for the diagnosis of prostate cancer: A systematic review
Stefano Marletta, Albino Eccher, Filippo Maria Martelli, Nicola Santonicco, Ilaria Girolami, Aldo Scarpa, Fabio Pagni, Vincenzo L’Imperio, Liron Pantanowitz, Stefano Gobbo, Davide Seminati, Angelo Paolo Dei Tos, Anil Parwani
American Journal of Clinical Pathology, 2024
Objectives The high incidence of prostate cancer causes prostatic samples to significantly affect pathology laboratories workflow and turnaround times (TATs). Whole-slide imaging (WSI) and artificial intelligence (AI) have both gained approval for primary diagnosis in prostate pathology, providing physicians with novel tools for their daily routine. Methods A systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was carried out in electronic databases to gather the available evidence on the application of AI-based algorithms to prostate cancer. Results Of 6290 articles, 80 were included, mostly (59%) dealing with biopsy specimens. Glass slides were digitized to WSI in most studies (89%), roughly two-thirds of which (66%) exploited convolutional neural networks for computational analysis. The algorithms achieved good to excellent results about cancer detection and grading, along with significantly reduced TATs. Furthermore, several studies showed a relevant correlation between AI-identified histologic features and prognostic predictive variables such as biochemical recurrence, extraprostatic extension, perineural invasion, and disease-free survival. Conclusions The published evidence suggests that AI can be reliably used for prostate cancer detection and grading, assisting pathologists in the time-consuming screening of slides. Further technologic improvement would help widening AI’s adoption in prostate pathology, as well as expanding its prognostic predictive potential.
Characterization of two transcriptomic subtypes of marker-null large cell carcinoma of the lung suggests different origin and potential new therapeutic perspectives
Michele Simbolo, Giovanni Centonze, Anastasios Gkountakos, Valentina Monti, Patrick Maisonneuve, Stela Golovco, Giovanna Sabella, Alessandro Del Gobbo, Stefano Gobbo, Stefano Ferrero, Alessandra Fabbri, Carlotta Pardo, Giovanna Garzone, Natalie Prinzi, Sara Pusceddu, Adele Testi, Luigi Rolli, Alessandro Mangogna, Luisa Bercich, Mauro Roberto Benvenuti, Emilio Bria, Sara Pilotto, Alfredo Berruti, Ugo Pastorino, Carlo Capella, Maurizio Infante, Michele Milella, Aldo Scarpa, Massimo Milione
Virchows Archiv, 2024
Pulmonary large cell carcinoma (LCC) is an undifferentiated neoplasm lacking morphological, histochemical, and immunohistochemical features of small cell lung cancer, adenocarcinoma (ADC), or squamous cell carcinoma (SCC). The available molecular information on this rare disease is limited. This study aimed to provide an integrated molecular overview of 16 cases evaluating the mutational asset of 409 genes and the transcriptomic profiles of 20,815 genes. Our data showed that TP53 was the most frequently inactivated gene (15/16; 93.7%) followed by RB1 (5/16; 31.3%) and KEAP1 (4/16; 25%), while CRKL and MYB genes were each amplified in 4/16 (25%) cases and MYC in 3/16 (18.8%) cases; transcriptomic analysis identified two molecular subtypes including a Pure-LCC and an adenocarcinoma like-LCC (ADLike-LCC) characterized by different activated pathways and cell of origin. In the Pure-LCC group, POU2F3 and FOXI1 were distinctive overexpressed markers. A tuft cell-like profile and the enrichment of a replication stress signature, particularly involving ATR, was related to this profile. Differently, the ADLike-LCC were characterized by an alveolar-cell transcriptomic profile and association with AIM2 inflammasome complex signature. In conclusion, our study split the histological marker-null LCC into two different transcriptomic entities, with POU2F3, FOXI1, and AIM2 genes as differential expression markers that might be probed by immunohistochemistry for the differential diagnosis between Pure-LCC and ADLike-LCC. Finally, the identification of several signatures linked to replication stress in Pure-LCC and inflammasome complex in ADLike-LCC could be useful for designing new potential therapeutic approaches for these subtypes.
TROP-2, NECTIN-4 and predictive biomarkers in sarcomatoid and rhabdoid bladder urothelial carcinoma
Matteo Brunelli, Stefano Gobbo, Giorgio Malpeli, Grazia Sirgiovanni, Claudia Caserta, Enrico Munari, Simona Francesconi, Anna Caliò, Guido Martignoni, Alessia Cimadamore, Alessandro Veccia, Alessandro Antonelli, Marcello Tucci, Francesco Pierconti, Isabelle Malak Hattab, Albino Eccher, Stefano Ascani, Michele Milella, Lucio Buffoni, Liang Cheng, Sergio Bracarda
Pathologica, 2024
A rare case of jejunal Vanek’s tumor causing intussusception in an adult: a case report and comprehensive literature overview
Nicolò Fabbri, Francesco Rimi, Valentina Sani, Antonio Pesce, Salvatore Greco, Stefano Gobbo, Carlo V Feo
Journal of Surgical Case Reports, 2023
mTOR eosinophilic renal cell carcinoma: a distinctive tumor characterized by mTOR mutation, loss of chromosome 1, cathepsin-K expression, and response to target therapy
Anna Caliò, Stefano Marletta, Giulio Settanni, Mimma Rizzo, Stefano Gobbo, Serena Pedron, Lavinia Stefanizzi, Enrico Munari, Matteo Brunelli, Lisa Marcolini, Anna Pesci, Stefano Fratoni, Francesco Pierconti, Maria Rosaria Raspollini, Antonio Marchetti, Claudio Doglioni, Mahul B. Amin, Camillo Porta, Guido Martignoni
Virchows Archiv, 2023
Validation of real-time prostatic biopsies evaluation with fluorescence laser confocal microscopy
Stefano GOBBO, Albino ECCHER, Sebastian GALLINA, Damiano D’AIETTI, Alessandro PRINCIOTTA, Francesco DITONNO, Alessandro TAFURI, Maria A. CERRUTO, Stefano MARLETTA, Francesca SANGUEDOLCE, Aldo SCARPA, Matteo BRUNELLI, Alessandro ANTONELLI
Minerva Urology and Nephrology, 2023
Minimally invasive versus open distal pancreatectomy for resectable pancreatic cancer (DIPLOMA): an international randomised non-inferiority trial
Maarten Korrel, Leia R. Jones, Jony van Hilst, Gianpaolo Balzano, Bergthor Björnsson, Ugo Boggi, Svein Olav Bratlie, Olivier R. Busch, Giovanni Butturini, Giovanni Capretti, Riccardo Casadei, Bjørn Edwin, Anouk M.L.H. Emmen, Alessandro Esposito, Massimo Falconi, Bas Groot Koerkamp, Tobias Keck, Ruben H.J. de Kleine, Dyre B. Kleive, Arto Kokkola, Daan J. Lips, Sanne Lof, Misha D.P. Luyer, Alberto Manzoni, Ravi Marudanayagam, Matteo de Pastena, Nicolò Pecorelli, John N. Primrose, Claudio Ricci, Roberto Salvia, Per Sandström, Frederique L.I.M. Vissers, Ulrich F. Wellner, Alessandro Zerbi, Marcel G.W. Dijkgraaf, Marc G. Besselink, Mohammad Abu Hilal, Adnan Alseidi, Constanza Aquilano, Johanna Arola, Denise Bianchi, Rachel Brown, Daniela Campani, Joanne ChinAleong, Jerome Cros, Lyubomira Dimitrova, Claudio Doglioni, Safi Dokmak, Russell Dorer, Michael Doukas, Jean Michel Fabre, Giovanni Ferrari, Viacheslay Grinevich, Stefano Gobbo, Thilo Hackert, Marius van den Heuvel, Clement Huijsentruijt, Mar Iglesias, Casper Jansen, Igor Khatkov, David Kooby, Marco Lena, Claudio Luchini, Krishna Menon, Patrick Michenet, Quintus Molenaar, Anna Nedkova, Andrea Pietrabissa, Mihaela Raicu, Rushda Rajak, Branislava Rankovic, Aniko Rendek, Benjamin Riviere, Antonio Sa Cunha, Olivier Saint Marc, Patricia Sanchez Velazquez, Donatella Santini, Aldo Scarpa, Mylene Sebagh, Donald Sears, Mihir Shah, Zahir Soonawalla, Paola Spaggiari, Lars Tharun, Tore Tholfsen, Ales Tomazic, Alessandro Vanoli, Caroline Verbeke, Joanne Verheij, Moritz Von Winterfeld, Roeland de Wilde, Vincent Yip, Yoh Zen
Lancet Regional Health Europe, 2023
STING is a prognostic factor related to tumor necrosis, sarcomatoid dedifferentiation, and distant metastasis in clear cell renal cell carcinoma
Stefano Marletta, Anna Caliò, Giuseppe Bogina, Mimma Rizzo, Matteo Brunelli, Serena Pedron, Lisa Marcolini, Lavinia Stefanizzi, Stefano Gobbo, Alessandro Princiotta, Camillo Porta, Angela Pecoraro, Alessandro Antonelli, Guido Martignoni
Virchows Archiv, 2023
Digital pathology world tour
Paola Chiara Rizzo, Alessandro Caputo, Eddy Maddalena, Nicolò Caldonazzi, Ilaria Girolami, Angelo Paolo Dei Tos, Aldo Scarpa, Marta Sbaraglia, Matteo Brunelli, Stefano Gobbo, Stefano Marletta, Liron Pantanowitz, Vincenzo Della Mea, Albino Eccher
Digital Health, 2023
TFE3 and TFEB-rearranged renal cell carcinomas: an immunohistochemical panel to differentiate from common renal cell neoplasms
Anna Caliò, Stefano Marletta, Matteo Brunelli, Serena Pedron, Sofia Canete Portillo, Diego Segala, Elena Bariani, Stefano Gobbo, George Netto, Guido Martignoni
Virchows Archiv, 2022
CXCR4-CXCL12-CXCR7 and PD-1/PD-L1 in Pancreatic Cancer: CXCL12 Predicts Survival of Radically Resected Patients
Crescenzo D’Alterio, Alessandro Giardino, Giosuè Scognamiglio, Giovanni Butturini, Luigi Portella, Giuseppe Guardascione, Isabella Frigerio, Marco Montella, Stefano Gobbo, Guido Martignoni, Vincenzo Napolitano, Ferdinando De Vita, Fabiana Tatangelo, Renato Franco, Stefania Scala
Cells, 2022
Validation of a Novel Three-Dimensional (3D Fusion) Gross Sampling Protocol for Clear Cell Renal Cell Carcinoma to Overcome Intratumoral Heterogeneity: The Meet-Uro 18 Study
Matteo Brunelli, Guido Martignoni, Giorgio Malpeli, Alessandro Volpe, Luca Cima, Maria Rosaria Raspollini, Mattia Barbareschi, Alessandro Tafuri, Giulia Masi, Luisa Barzon, Serena Ammendola, Manuela Villanova, Maria Angela Cerruto, Michele Milella, Sebastiano Buti, Melissa Bersanelli, Giuseppe Fornarini, Sara Elena Rebuzzi, Valerio Gaetano Vellone, Gabriele Gaggero, Giuseppe Procopio, Elena Verzoni, Sergio Bracarda, Martina Fanelli, Roberto Sabbatini, Rodolfo Passalacqua, Bruno Perrucci, Maria Olga Giganti, Maddalena Donini, Stefano Panni, Marcello Tucci, Veronica Prati, Cinzia Ortega, Anna Caliò, Albino Eccher, Filippo Alongi, Giovanni Pappagallo, Roberto Iacovelli, Alessandra Mosca, Paolo Umari, Ilaria Montagnani, Stefano Gobbo, Francesco Atzori, Enrico Munari, Marco Maruzzo, Umberto Basso, Francesco Pierconti, Carlo Patriarca, Piergiuseppe Colombo, Alberto Lapini, Giario Conti, Roberto Salvioni, Enrico Bollito, Andrea Cossarizza, Francesco Massari, Mimma Rizzo, Renato Franco, Federica Zito-Marino, Yoseba Aberasturi Plata, Francesca Galuppini, Marta Sbaraglia, Matteo Fassan, Angelo Paolo Dei Tos, Maurizio Colecchia, Holger Moch, Maurizio Scaltriti, Camillo Porta, Brett Delahunt, Gianluca Giannarini, Roberto Bortolus, Pasquale Rescigno, Giuseppe Luigi Banna, Alessio Signori, Miguel Angel Llaja Obispo, Roberto Perris, Alessandro Antonelli
Journal of Personalized Medicine, 2022
TSC loss is a clonal event in eosinophilic solid and cystic renal cell carcinoma: a multiregional tumor sampling study
Enrico Munari, Giulio Settanni, Anna Caliò, Diego Segala, Sara Lonardi, Silvia Sandrini, Paola Vacca, Nicola Tumino, Marcella Marconi, Matteo Brunelli, Stefano Gobbo, George J. Netto, Lorenzo Moretta, Giuseppe Zamboni, Guido Martignoni
Modern Pathology, 2022
Serous Neoplasms
Paola Capelli, Paolo Tinazzi Martini, Giovanni Morana, Riccardo de Robertis, Claudio Luchini, Stefano Gobbo, Mirko D’Onofrio
Imaging and Pathology of Pancreatic Neoplasms A Pictorial Atlas Second Edition, 2022
Neuroendocrine Neoplasms
Riccardo De Robertis, Mirko D’Onofrio, Paolo Tinazzi Martini, Stefano Gobbo, Maria Gaia Mastrosimini, Lavinia Stefanizzi, Alessandro Beleù, Luca Geraci, Aldo Scarpa, Paola Capelli
Imaging and Pathology of Pancreatic Neoplasms A Pictorial Atlas Second Edition, 2022
Role of next-generation genomic sequencing in targeted agents repositioning for pancreaticoduodenal cancer patients
Davide Melisi, Alessandro Cavaliere, Stefano Gobbo, Giulia Fasoli, Valentina Allegrini, Francesca Simionato, Marina Gaule, Simona Casalino, Camilla Pesoni, Camilla Zecchetto, Valeria Merz, Andrea Mambrini, Emilio Barbi, Roberto Girelli, Alessandro Giardino, Isabella Frigerio, Roberto Scalamogna, Arianna Avitabile, Silvia Castellani, Michele Milella, Giovanni Butturini
Pancreatology, 2021
Stimulator of interferon genes (STING) immunohistochemical expression in the spectrum of perivascular epithelioid cell (PEC) lesions of the kidney
Anna Caliò, Matteo Brunelli, Stefano Gobbo, Serena Pedron, Diego Segala, Pedram Argani, Guido Martignoni
Pathology, 2021
Cathepsin k: A novel diagnostic and predictive biomarker for renal tumors
Anna Caliò, Matteo Brunelli, Stefano Gobbo, Pedram Argani, Enrico Munari, George Netto, Guido Martignoni
Cancers, 2021
Parvalbumin immunohistochemical expression in the spectrum of perivascular epithelioid cell (PEC) lesions of the kidney
Anna Caliò, Serena Ammendola, Matteo Brunelli, Serena Pedron, Stefano Gobbo, Guido Martignoni
Virchows Archiv, 2021
Magnetic resonance (MR) for mural nodule detection studying Intraductal papillary mucinous neoplasms (IPMN) of pancreas: Imaging-pathologic correlation
Mirko D'Onofrio, Giorgia Tedesco, Nicolò Cardobi, Riccardo De Robertis, Alessandro Sarno, Paola Capelli, Paolo Tinazzi Martini, Gabriele Giannotti, Alessandro Beleù, Giovanni Marchegiani, Stefano Gobbo, Giovanni Butturini, Bogdan Maris, Roberto Salvia, Claudio Bassi
Pancreatology, 2021
Correlation of MR features and histogram-derived parameters with aggressiveness and outcomes after resection in pancreatic ductal adenocarcinoma
Riccardo De Robertis, Alessandro Beleù, Nicolò Cardobi, Isabella Frigerio, Silvia Ortolani, Stefano Gobbo, Bogdan Maris, Davide Melisi, Stefania Montemezzi, Mirko D’Onofrio
Abdominal Radiology, 2020
Genetic Analysis of Small Well-differentiated Pancreatic Neuroendocrine Tumors Identifies Subgroups with Differing Risks of Liver Metastases
Antonio Pea, Jun Yu, Luigi Marchionni, Michael Noe, Claudio Luchini, Alessandra Pulvirenti, Roeland F. de Wilde, Lodewijk A. Brosens, Neda Rezaee, Ammar Javed, Peter Chianchiano, Stefano Gobbo, Paolo Regi, Roberto Salvia, Claudio Bassi, Jin He, Matthew J. Weiss, John L. Cameron, G. Johan A. Offerhaus, Ralph H. Hruban, Rita T. Lawlor, Aldo Scarpa, Christopher M. Heaphy, Laura D. Wood, Christopher L. Wolfgang
Annals of Surgery, 2020
A phase II study of liposomal irinotecan with 5-fluorouracil, leucovorin and oxaliplatin in patients with resectable pancreatic cancer: the nITRO trial
Francesca Simionato, Camilla Zecchetto, Valeria Merz, Alessandro Cavaliere, Simona Casalino, Marina Gaule, Mirko D’Onofrio, Giuseppe Malleo, Luca Landoni, Alessandro Esposito, Giovanni Marchegiani, Luca Casetti, Massimiliano Tuveri, Salvatore Paiella, Filippo Scopelliti, Alessandro Giardino, Isabella Frigerio, Paolo Regi, Paola Capelli, Stefano Gobbo, Armando Gabbrielli, Laura Bernardoni, Vita Fedele, Irene Rossi, Cristiana Piazzola, Serena Giacomazzi, Martina Pasquato, Morena Gianfortone, Stefano Milleri, Michele Milella, Giovanni Butturini, Roberto Salvia, Claudio Bassi, Davide Melisi
Therapeutic Advances in Medical Oncology, 2020
Tamoxifen related Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A case report and literature review of this possible association
Diego Segala, Stefano Gobbo, Anna Pesci, Guido Martignoni, Angela Santoro, Giuseppe Angelico, Damiano Arciuolo, Saveria Spadola, Michele Valente, Giovanni Scambia, Gian Franco Zannoni
Pathology Research and Practice, 2019
Histopathology and Long-Term Outcome of Kidneys Transplanted From Donors With Severe Acute Kidney Injury
Luca Cima, Francesco Nacchia, Claudio Ghimenton, Giovanni Valotto, Luigino Boschiero, Stefano Gobbo, Gianluigi Zaza, Desley Neil, Claudia Mescoli, Francesca Vanzo, Antonietta D’Errico, Caterina Ghimenton, Massimo Rugge, Marilena Casartelli-Liviero, Matteo Brunelli, Luca Novelli, Albino Eccher
Progress in Transplantation, 2019
Intravoxel incoherent motion diffusion-weighted MR imaging of solid pancreatic masses: reliability and usefulness for characterization
Riccardo De Robertis, Nicolò Cardobi, Silvia Ortolani, Paolo Tinazzi Martini, Alto Stemmer, Robert Grimm, Stefano Gobbo, Giovanni Butturini, Mirko D’Onofrio
Abdominal Radiology, 2019
T(6;11) renal cell carcinoma: A study of seven cases including two with aggressive behavior, and utility of CD68 (PG-M1) in the differential diagnosis with pure epithelioid PEComa/epithelioid angiomyolipoma
Anna Caliò, Matteo Brunelli, Diego Segala, Serena Pedron, Regina Tardanico, Andrea Remo, Stefano Gobbo, Emanuela Meneghelli, Claudio Doglioni, Ondrej Hes, Claudia Zampini, Pedram Argani, Guido Martignoni
Modern Pathology, 2018
Tumor thrombosis: a peculiar finding associated with pancreatic neuroendocrine neoplasms. A pictorial essay
Riccardo De Robertis, Salvatore Paiella, Nicolò Cardobi, Luca Landoni, Paolo Tinazzi Martini, Silvia Ortolani, Giulia De Marchi, Stefano Gobbo, Alessandro Giardino, Giovanni Butturini, Giampaolo Tortora, Claudio Bassi, Mirko D’Onofrio
Abdominal Radiology, 2018
Can histogram analysis of mr images predict aggressiveness in pancreatic neuroendocrine tumors?
Riccardo De Robertis, Bogdan Maris, Nicolò Cardobi, Paolo Tinazzi Martini, Stefano Gobbo, Paola Capelli, Silvia Ortolani, Sara Cingarlini, Salvatore Paiella, Luca Landoni, Giovanni Butturini, Paolo Regi, Aldo Scarpa, Giampaolo Tortora, Mirko D’Onofrio
European Radiology, 2018
Proximal CD13 Versus Distal GATA-3 Expression in Renal Neoplasia According to WHO 2016 Classification
Matteo Brunelli, Francesco Erdini, Luca Cima, Albino Eccher, Adele Fioravanzo, Stefano Gobbo, Diego Segala, Claudio Ghimenton, Guido Mazzoleni, Enrico Munari, Rodolfo Carella, Guido Martignoni
Applied Immunohistochemistry and Molecular Morphology, 2018
Downstaging in Stage IV Pancreatic Cancer: A New Population Eligible for Surgery?
Isabella Frigerio, Paolo Regi, Alessandro Giardino, Filippo Scopelliti, Roberto Girelli, Claudio Bassi, Stefano Gobbo, Paolo Tinazzi Martini, Paola Capelli, Mirko D’Onofrio, Giuseppe Malleo, Laura Maggino, Elena Viviani, Giovanni Butturini
Annals of Surgical Oncology, 2017
Pancreatic neuroendocrine neoplasms: Magnetic resonance imaging features according to grade and stage
Riccardo De Robertis, Sara Cingarlini, Paolo Tinazzi Martini, Silvia Ortolani, Giovanni Butturini, Luca Landoni, Paolo Regi, Roberto Girelli, Paola Capelli, Stefano Gobbo, Giampaolo Tortora, Aldo Scarpa, Paolo Pederzoli, Mirko D’Onofrio
World Journal of Gastroenterology, 2017
Validation of 34betaE12 immunoexpression in clear cell papillary renal cell carcinoma as a sensitive biomarker
Guido Martignoni, Matteo Brunelli, Diego Segala, Enrico Munari, Stefano Gobbo, Luca Cima, Ioana Borze, Tina Wirtanen, Virinder Kaur Sarhadi, Lilit Atanesyan, Suvi Savola, Luisa Barzon, Giulia Masi, Matteo Fassan, John N. Eble, Tom Bohling, Liang Cheng, Brett Delahunt, Sakari Knuutila
Pathology, 2017
Oncocytic intraductal papillary mucinous neoplasms of the pancreas imaging and histopathological findings
Mirko D’Onofrio, Riccardo De Robertis, Paolo Tinazzi Martini, Paola Capelli, Stefano Gobbo, Giovanni Morana, Emanuele Demozzi, Giovanni Marchegiani, Roberto Girelli, Roberto Salvia, Claudio Bassi, Paolo Pederzoli
Pancreas, 2016
Pancreatic Neuroendocrine Neoplasms: Clinical Value of Diffusion-Weighted Imaging
Riccardo De Robertis, Mirko D'Onofrio, Giulia Zamboni, Paolo Tinazzi Martini, Stefano Gobbo, Paola Capelli, Giovanni Butturini, Roberto Girelli, Silvia Ortolani, Sara Cingarlini, Paolo Pederzoli, Aldo Scarpa
Neuroendocrinology, 2016
Ultrasound-guided percutaneous fine-needle aspiration of solid pancreatic neoplasms: 10-year experience with more than 2,000 cases and a review of the literature
Mirko D’Onofrio, Riccardo De Robertis, Emilio Barbi, Enrico Martone, Erminia Manfrin, Stefano Gobbo, Gino Puntel, Franco Bonetti, Roberto Pozzi Mucelli
European Radiology, 2016
Uncommon presentations of common pancreatic neoplasms: a pictorial essay
Mirko D’Onofrio, Riccardo De Robertis, Paola Capelli, Paolo Tinazzi Martini, Stefano Crosara, Stefano Gobbo, Giovanni Butturini, Roberto Salvia, Emilio Barbi, Roberto Girelli, Claudio Bassi, Paolo Pederzoli
Abdominal Imaging, 2015
iPathology cockpit diagnostic station: Validation according to College of American Pathologists Pathology and Laboratory Quality Center recommendation at the Hospital Trust and University of Verona
Matteo Brunelli, Serena Beccari, Romano Colombari, Stefano Gobbo, Luca Giobelli, Andrea Pellegrini, Marco Chilosi, Maria Lunardi, Guido Martignoni, Aldo Scarpa, Albino Eccher
Diagnostic Pathology, 2014
Neuroendocrine Neoplasms
Imaging and Pathology of Pancreatic Neoplasms A Pictorial Atlas, 2014
Serous Neoplasms
Imaging and Pathology of Pancreatic Neoplasms A Pictorial Atlas, 2014
Clear cell papillary renal cell carcinoma: Micro-RNA expression profiling and comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma
Enrico Munari, Luigi Marchionni, Apurva Chitre, Masamichi Hayashi, Guido Martignoni, Matteo Brunelli, Stefano Gobbo, Pedram Argani, Mohamad Allaf, Mohammad O. Hoque, George J. Netto
Human Pathology, 2014
Renal cell carcinoma with smooth muscle stroma lacks chromosome 3p and VHL alterations
Guido Martignoni, Matteo Brunelli, Diego Segala, Stefano Gobbo, Ioana Borze, Lilit Atanesyan, Suvi Savola, Luisa Barzon, Giulia Masi, Regina Tardanico, Shaobo Zhang, John N Eble, Marco Chilosi, Tom Böhling, Liang Cheng, Brett Delahunt, Sakari Knuutila
Modern Pathology, 2014
Clear cell papillary renal cell carcinoma-like tumors in patients with von hippel-lindau disease are unrelated to sporadic clear cell papillary renal cell carcinoma
Sean R. Williamson, Shaobo Zhang, John N. Eble, David J. Grignon, Guido Martignoni, Matteo Brunelli, Mingsheng Wang, Stefano Gobbo, Lee Ann Baldridge, Liang Cheng
American Journal of Surgical Pathology, 2013
Results of 100 pancreatic radiofrequency ablations in the context of a multimodal strategy for stage III ductal adenocarcinoma
Roberto Girelli, Isabella Frigerio, Alessandro Giardino, Paolo Regi, Stefano Gobbo, Giuseppe Malleo, Roberto Salvia, Claudio Bassi
Langenbeck S Archives of Surgery, 2013
True 3q Chromosomal Amplification in Squamous Cell Lung Carcinoma by FISH and aCGH Molecular Analysis: Impact on Targeted Drugs
Matteo Brunelli, Emilio Bria, Alessia Nottegar, Sara Cingarlini, Francesca Simionato, Anna Caliò, Albino Eccher, Claudia Parolini, Antonio Iannucci, Eliana Gilioli, Serena Pedron, Francesco Massari, Giampaolo Tortora, Ioana Borze, Sakari Knuutila, Stefano Gobbo, Antonio Santo, Luca Tondulli, Francesco Calabrò, Guido Martignoni, Marco Chilosi
Plos One, 2012
Oncocytic papillary renal cell carcinoma: Potential pitfall in small enucleation
Pathologica, 2012
Classical lobular breast carcinoma consistently lacks topoisomerase-IIα gene amplification: Implications for the tailored use of anthracycline-based chemotherapies
Eleonora Brunello, Matteo Brunelli, Erminia Manfrin, Alessia Nottegar, Samantha Bersani, Marco Vergine, Annamaria Molino, Elena Fiorio, Marco Chilosi, Stefano Gobbo, Guido Martignoni, Franco Bonetti
Histopathology, 2012
Cathepsin K expression in the spectrum of perivascular epithelioid cell (PEC) lesions of the kidney
Guido Martignoni, Franco Bonetti, Marco Chilosi, Matteo Brunelli, Diego Segala, Mahul B Amin, Pedram Argani, John N Eble, Stefano Gobbo, Maurizio Pea
Modern Pathology, 2012
FISH scoring on paraffin sections versus single-cell suspension for chromophobe renal carcinoma and renal oncocytoma
Anticancer Research, 2011
Many facets of chromosome 3p cytogenetic findings in clear cell renal carcinoma: The need for agreement in assessment FISH analysis to avoid diagnostic errors
Histology and Histopathology, 2011
Differential expression of cathepsin K in neoplasms harboring TFE3 gene fusions
Guido Martignoni, Stefano Gobbo, Philippe Camparo, Matteo Brunelli, Enrico Munari, Diego Segala, Maurizio Pea, Franco Bonetti, Peter B Illei, Georges J Netto, Marc Ladanyi, Marco Chilosi, Pedram Argani
Modern Pathology, 2011
Renal cell neoplasms of oncocytosis have distinct morphologic, immunohistochemical, and cytogenetic profiles
Stefano Gobbo, John N. Eble, Brett Delahunt, David J. Grignon, Hemamali Samaratunga, Guido Martignoni, Shaobo Zhang, Mingsheng Wang, Matteo Brunelli, Paolo Cossu-Rocca, Liang Cheng
American Journal of Surgical Pathology, 2010
Molecular pathology of lymphangioleiomyomatosis and other perivascular epithelioid cell tumors
Guido Martignoni, Maurizio Pea, Daniela Reghellin, Stefano Gobbo, Giuseppe Zamboni, Marco Chilosi, Franco Bonetti
Archives of Pathology and Laboratory Medicine, 2010
Utility of racemase and other immunomarkers in the detection of adenocarcinoma in prostatic tissue damaged by high intensity focused ultrasound therapy
Daniela Dalfior, Brett Delahunt, Matteo Brunelli, Alice Parisi, Vincenzo Ficarra, Giacomo Novara, Giovanni Novella, Stefano Gobbo, Claudio Valotto, Marco Chilosi, Fabio Menestrina, Guido Martignoni
Pathology, 2010
Diagnostic usefulness of fluorescent cytogenetics in differentiating chromophobe renal cell carcinoma from renal oncocytoma: A validation study combining metaphase and interphase analyses
Matteo Brunelli, Brett Delahunt, Stefano Gobbo, Regina Tardanico, Albino Eccher, Samantha Bersani, Paolo Cossu-Rocca, Claudia Parolini, Piera Balzarini, Fabio Menestrina, Liang Cheng, John Nelson Eble, Guido Martignoni
American Journal of Clinical Pathology, 2010
Utility of tissue microarrays for assessment of chromosomal abnormalities in chromophobe renal cell carcinoma
Analytical and Quantitative Cytology and Histology, 2009
S-100A1 is a reliable marker in distinguishing nephrogenic adenoma from prostatic adenocarcinoma
Paolo Cossu-Rocca, Marcella Contini, Matteo Brunelli, Antonella Festa, Francesca Pili, Stefano Gobbo, Albino Eccher, Antonica Mura, Giovannino Massarelli, Guido Martignoni
American Journal of Surgical Pathology, 2009
Subepithelial pelvic hematoma (Antopol-Goldman lesion) simulating renal neoplasm: Report of a case and review of the literature
Albino Eccher, Matteo Brunelli, Stefano Gobbo, Claudio Ghimenton, Gaetano Grosso, Antonio Iannucci, Paolo Dalla Palma, Fabio Menestrina, Guido Martignoni
International Journal of Surgical Pathology, 2009
Her-2/neu evaluation in Sister Mary Joseph's nodule from breast carcinoma: A case report and review of the literature
Matteo Brunelli, Erminia Manfrin, Keith Miller, Albino Eccher, Stefano Gobbo, Daniela Reghellin, Marco Chilosi, Andrea Remo, Guido Martignoni, Fabio Menestrina, Franco Bonetti
Journal of Cutaneous Pathology, 2009
Expression pattern of claudins 5 and 7 distinguishes solid-pseudopapillary from pancreatoblastoma, acinar cell and endocrine tumors of the pancreas
Fabrizio Comper, Davide Antonello, Stefania Beghelli, Stefano Gobbo, Licia Montagna, Paolo Pederzoli, Marco Chilosi, Aldo Scarpa
American Journal of Surgical Pathology, 2009
Genotypic intratumoral heterogeneity in breast carcinoma with HER2/fieif emplification wvaluation according to ASCO/CAP criteria
Matteo Brunelli, Erminia Manfrin, Guido Martignoni, Keith Miller, Andrea Remo, Daniela Reghellin, Samantha Bersani, Stefano Gobbo, Albino Eccher, Marco Chilosi, Franco Bonetti
American Journal of Clinical Pathology, 2009
Update on the molecular pathogenesis of pancreatic tumors other than common ductal adenocarcinoma
D. Antonello, S. Gobbo, V. Corbo, B. Sipos, N.R. Lemoine, A. Scarpa
Pancreatology, 2009
Cathepsin-k expression in pulmonary lymphangioleiomyomatosis
Marco Chilosi, Maurizio Pea, Guido Martignoni, Matteo Brunelli, Stefano Gobbo, Venerino Poletti, Franco Bonetti
Modern Pathology, 2009
Cathepsin-K immunoreactivity distinguishes MiTF/TFE family renal translocation carcinomas from other renal carcinomas
G Martignoni, M Pea, S Gobbo, M Brunelli, F Bonetti, D Segala, Chin-Chen Pan, G Netto, C Doglioni, O Hes, P Argani, M Chilosi
Modern Pathology, 2009
Renal cell carcinomas with papillary architecture and clear cell components: The utility of immunohistochemical and cytogenetical analyses in differential diagnosis
Stefano Gobbo, John N. Eble, Gregory T. MacLennan, David J. Grignon, Rajal B. Shah, Shaobo Zhang, Guido Martignoni, Matteo Brunelli, Liang Cheng
American Journal of Surgical Pathology, 2008
Fluorescent cytogenetics of renal cell neoplasms
Pathologica, 2008
Renal cell carcinomas with papillary architecture and clear cell components: The utility of immunohistochemical and cytogenetical analyses in differential diagnosis: Editorial comment
International Braz J Urol, 2008
Primary pleomorphic rhabdomyosarcoma of the kidney in an adult
Daniela Dalfior, Albino Eccher, Stefano Gobbo, Matteo Brunelli, Guido Martignoni, Fabio Menestrina, Palma Paolo Dalla, Gordan Dvornik
Annals of Diagnostic Pathology, 2008
Clear cell papillary renal cell carcinoma: A distinct histopathologic and molecular genetic entity
Stefano Gobbo, John N. Eble, David J. Grignon, Guido Martignoni, Gregory T. MacLennan, Rajal B. Shah, Shaobo Zhang, Matteo Brunelli, Liang Cheng
American Journal of Surgical Pathology, 2008
Schwannoma of the kidney
Stefano Gobbo, John N Eble, Jiaoti Huang, David J Grignon, Mingsheng Wang, Guido Martignoni, Matteo Brunelli, Liang Cheng
Modern Pathology, 2008
Molecular diagnosis of renal cell neoplasms: The usefullness of immunohistochemistry and fluorescence in situ hybridization
Stefano Gobbo, Matteo Brunelli, Albino Eccher, Franco Bonetti, Fabio Menestrina, Guido Martignoni
Expert Opinion on Medical Diagnostics, 2008
Periorbital subcutaneous tumor-like lesion due to Dirofilaria repens
Albino Eccher, Daniela Dalfior, Stefano Gobbo, Guido Martignoni, Matteo Brunelli, Walter Decaminada, Franco Bonetti, Francesco Rivasi, Mattia Barbareschi, Fabio Menestrina
International Journal of Surgical Pathology, 2008
Loss of chromosome 9p is an independent prognostic factor in patients with clear cell renal cell carcinoma
Matteo Brunelli, Albino Eccher, Stefano Gobbo, Vincenzo Ficarra, Giacomo Novara, Paolo Cossu-Rocca, Franco Bonetti, Fabio Menestrina, Liang Cheng, John N Eble, Guido Martignoni
Modern Pathology, 2008
Renal tumors: Epidemiology, etiology, and clinical history: Pathology: Tumor genetics: Differential diagnosis and use of ancillary methods for diagnosis: Principles of staging and grading: Pediatric tumors
Clinical Pathology of Urological Tumours, 2007
Chondroid syringoma with extensive ossification
Albino Eccher, Matteo Brunelli, Stefano Gobbo, Daniela Dalfior, Gordan Dvornik, Mattia Barbareschi, Claudia Parolini, Fabio Menestrina, Guido Martignoni
International Journal of Surgical Pathology, 2007
Necrotizing enterocolitis in a 850 gram infant receiving sorbitol-free sodium polystyrene sulfonate (Kayexalate): Clinical and histopathologic findings
S Rugolotto, M Gruber, P D Solano, L Chini, S Gobbo, S Pecori
Journal of Perinatology, 2007
Role of molecular markers in diagnosis and prognosis of renal cell carcinoma
Analytical and Quantitative Cytology and Histology, 2007
Chromosomal gains in the sarcomatoid transformation of chromophobe renal cell carcinoma
Matteo Brunelli, Stefano Gobbo, Paolo Cossu-Rocca, Liang Cheng, Ondrej Hes, Brett Delahunt, Maurizio Pea, Franco Bonetti, Maria M Mina, Vincenzo Ficarra, Marco Chilosi, John N Eble, Fabio Menestrina, Guido Martignoni
Modern Pathology, 2007
Diagnostic utility of S100A1 expression in renal cell neoplasms: An immunohistochemical and quantitative RT-PCR study
Paolo Cossu Rocca, Matteo Brunelli, Stefano Gobbo, Albino Eccher, Emma Bragantini, Maria M Mina, Vincenzo Ficarra, Filiberto Zattoni, Alberto Zamò, Maurizio Pea, Aldo Scarpa, Marco Chilosi, Fabio Menestrina, Franco Bonetti, John N Eble, Guido Martignoni
Modern Pathology, 2007
Prognostic Role of the Histologic Subtypes of Renal Cell Carcinoma after Slide Revision
Vincenzo Ficarra, Guido Martignoni, Antonio Galfano, Giacomo Novara, Stefano Gobbo, Matteo Brunelli, Maurizio Pea, Filiberto Zattoni, Walter Artibani
European Urology, 2006
Diagnostic and prognostic markers in renal tumors
Pathologica, 2005
Leptin in adipose tissue - Morphological aspects
European Journal of Anatomy, 2004

Stefano Gobbo

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