Faraj Ahmad Faraj Abuilaiwi

@uhb.edu.sa

University of Hafr AlBatin - College of Science - Department of Chemistry
University of Hafr AlBatin

Faraj Ahmad Faraj Abuilaiwi


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https://researchid.co/faraj_ah

RESEARCH, TEACHING, or OTHER INTERESTS

Organic Chemistry, Polymers and Plastics, Water Science and Technology, Pharmaceutical Science
21

Scopus Publications

Scopus Publications

  • Drug Formulation of Securigera securidaca Seed Extracts
    Mohamed E. M. Abdelbagi, Ghassab M. Al-Mazaideh, Adil Elhag Ahmed, Fuad Al-Rimawi, Haya Ayyal Salman, Abdulrahman Almutairi, Faraj Ahmad Abuilaiwi, Fadel Wedian
    Processes, 2023
    S. securidaca seeds are reported to treat a variety of diseases; they contain multiple antidiabetic constituents and are widely used as anti-hyperglycemic, antibacterial, as well as anti-hyperlipidemic agents. The present work aimed to propose tablet formulations containing extracts of S. securidaca seeds in an attempt to obtain antibacterial and anti-hyperglycemic formulations with a more efficient oral hypoglycemic impact, limited side effects, and higher patient compliance for the first time, resulting in multiple benefits. Tablet formulations were created by encapsulating granules from S. securidaca seed extracts with varying concentrations of sodium starch glycolate as a super-disintegrant (0–3%). The final formulations were examined for weight variation, solubility, hardness, water content, disintegration time, friability, drug content (trigonelline and diosgenin), and in vitro drug release. The S. securidaca tablet formulations completed the weight test because the percentage deviation in the personal tablet weight and mechanical resistance from the mean were identified to be within the average range. In accordance with the results, formulations containing diosgenin as well as trigonelline as a super-disintegrant were identified as the ideal formulations. The amount of the active substance released from the tablet (S. securidaca seed extract formulation) was consistent throughout the results with the standard methods recommended by the FDA (94.05%) for diosgenin and 87.25% for trigonelline after 45 min. The acceptable limit, according to the FDA, is not more than (N.L.T.) 80% after 45 min for phase #1. The present study aimed to obtain an optimized formula for S. securidaca extract tablets that met the requirements of a good pharmaceutical preparation according to the United States Pharmacopeia (USP) and National Formulary (NF). This has important implications for the development of novel, effective treatments and significantly advances the development of natural medicine. Our findings are expected to be of interest to researchers, clinicians, and other experts in this field of study. Based on these findings, it can be inferred that the formulation of S. securidaca seed extracts with appropriate and compatible herbal dosage forms has fewer side effects and is more effective than traditional treatments.
  • Exploring Securigera securidaca Seeds as a Source of Potential CDK1 Inhibitors: Identification of Hippeastrine and Naringenin as Promising Hit Candidates
    Mohamed E. M. Abdelbagi, Ghassab M. Al-Mazaideh, Adil Elhag Ahmed, Fuad Al-Rimawi, Haya Ayyal Salman, Abdulrahman Almutairi, Faraj Ahmad Abuilaiwi, Fadel Wedian
    Processes, 2023
    CDK1 (cyclin dependent kinase 1) is a key regulator of the cell cycle and is frequently dysregulated in cancer, making it a promising target for anticancer therapy. Securigera securidaca L. (S. securidaca) seeds, traditionally used in folk medicine for various ailments including cancer, were examined for their potential as CDK1/Cks2 inhibitors using in silico approaches. A total of 14 phytocompounds was identified in the GC/MS chromatogram, with gingerone being the most abundant at 25.67% and hippeastrine the least at 2%. Major constituents of the essential extract, including gingerol, eugenol, α-curcumene, and gingerol, showed high values and made up 52% of the total content of the volatile extract. Molecular docking and ADMET studies suggested that hippeastrine and naringenin are potential hit candidates against CDK1, exhibiting good drug-like properties and molecular interactions with desirable pharmacokinetic and toxicological characteristics close to dinaciclib. Furthermore, molecular dynamics (MD) simulations showed that both compounds exhibited stable conformations inside the binding site over the 100 ns MD simulation, suggesting they may stabilize the protein structure by reducing the flexibility of the CDK1 backbone. Additionally, MM-PBSA calculations further supported the stability of hippeastrine and naringenin in CDK1 complexes. Overall, these findings suggest that hippeastrine and naringenin are potential hit candidates for CDK1 inhibition, providing valuable insight into their binding and stability within the active site of CDK1. Further investigation of these compounds with in vitro and in vivo assays is warranted to assess their potential as CDK1 inhibitors for cancer therapy.
  • Gd-doped BiVO4 microstructure and its composite with a flat carbonaceous matrix to boost photocatalytic performance
    Sheraz Bashir, Akmal Jamil, Muhammad Shahzeb Khan, Amira Alazmi, Faraj Ahmad Abuilaiwi, Muhammad Shahid
    Journal of Alloys and Compounds, 2022
  • Al3+doping reduces the electron/hole recombination in photoluminescent copper ferrite (CuFe2-xAlxO4) nanocrystallites
    Faraj Ahmad Abuilaiwi, Muhammad Awais, Umair Yaqub Qazi, Farman Ali, Adeel Afzal
    Boletin De La Sociedad Espanola De Ceramica Y Vidrio, 2022
    Nanocrystalline copper ferrite shows distinct photocatalytic properties, but it suffers from a high recombination rate of photogenerated electrons (e−) and holes (h+) due to its narrow bandgap. Herein, Al3+ doping is shown to reduce the (e−/h+) recombination rate and improve the charge carriers’ availability in doped CuFe2−xAlxO4 (0 ≤ x ≤ 1) nanoparticles produced by a solid-state, mechanochemical process. CuFe2−xAlxO4 (0 ≤ x ≤ 1) nanoparticles exhibit the growth of a nanocrystalline cubic spinel lattice when annealed at 1000 °C. The lattice parameter is reduced by Al3+ doping due to the smaller ionic radius of Al3+ ions substituting bigger Fe3+ ions. However, a higher degree of sintering and greater crystallite size are observed for Al3+ doped samples. The surface morphology and topography also reveal an increase in the particle size, but significantly narrow size distribution and greater homogeneity. The effect of Al3+ doping on the optical properties of CuFe2−xAlxO4 (0 ≤ x ≤ 1) nanoparticles is demonstrated by a decrease in the photoluminescence signal that is attributed to the lower rate of (e−/h+) recombination. Thus, Al3+ doping increases transition time and improves the availability of charge carriers for potential photocatalytic applications. La ferrita de cobre nanocristalino muestra propiedades fotocatalíticas distintas, pero sufre de una alta tasa de recombinación de electrones fotogenerados (e−) y agujeros (h+) debido a su estrecha banda prohibida. Aquí, se muestra que el dopaje Al3+ reduce la tasa de recombinación (e-/h+) y mejora la disponibilidad de los portadores de carga en nanopartículas de CuFe2-xAlxO4 (0 ≤ x ≤ 1) dopadas producidas por un proceso mecanoquímico de estado sólido. Las nanopartículas de CuFe2-xAlxO4 (0 ≤ x ≤ 1) exhiben el crecimiento de una red de espinela cúbica nanocristalina, cuando se recocen a 1000 °C. El parámetro de red se reduce por el dopaje Al3+ debido al radio iónico más pequeño de los iones Al3+ que sustituyen los iones Fe3+ más grandes. Sin embargo, se observa un mayor grado de sinterización y un mayor tamaño de cristalito para las muestras dopadas con Al3+. La morfología y la topografía de la superficie también revelan un aumento en el tamaño de partícula, pero una distribución del tamaño significativamente más estrecha y una mayor homogeneidad. El efecto del dopaje Al3+ sobre las propiedades ópticas de las nanopartículas de CuFe2-xAlxO4 (0 ≤ x ≤ 1) se demuestra por una disminución en la señal de fotoluminiscencia que se atribuye a la tasa más baja de recombinación (e-/h+). Por lo tanto, el dopaje Al3+ aumenta el tiempo de transición y mejora la disponibilidad de portadores de carga para posibles aplicaciones fotocatalíticas.
  • Solid-state synthesis of heterogeneous Ni0.5Cu0.5-xZn xFe2O4 spinel oxides with controlled morphology and tunable dielectric properties
    Adeel Afzal, Faraj Ahmad Abuilaiwi, Rahat Javaid, Farman Ali, Amir Habib
    Journal of Materials Science Materials in Electronics, 2020
  • Removal of Cadmium (II), Chromium (III), and Lead (II) Heavy Metal Ions from Water by Graft Copolymerization of Acrylonitrile onto Date Palm Fiber Using H2O2/Fe++as an Initiator
    Faraj Ahmad Abuilaiwi
    International Journal of Polymer Science, 2020
    The study is aimed at assessing how the date palm wood fibers (DPWF) can be used for the removal of heavy metals from water. The study involved examination of the radical polymerization and graft polymerization parameters such as reaction period, reaction time, monomer volume, amount of the catalyst, and concentration of initiator to obtain the maximum yield of graft polymerization. Fiber and copolymer were characterized using SEM and FT-IR spectroscopy to ensure the completion of polymerization. Hydroxylamine hydrochloride was used for treating the grafted copolymers for the preparation of polyamidoxime chelating resin, which was then examined for removing the heavy metal ions. Different resin dosages, contact time, and initial concentrations were used, and the batch technique experiment was utilized. The study also applied the Langmuir and Freundlich isotherm model, and Langmuir was found to be better. The absorption ability was found to be better for polyamidoxime resin for metal ions of cadmium (II), chromium (III), and lead (II).
  • Corrigendum to: Effect of Carboxylic Functional Group Functionalized on Carbon Nanotubes Surface on the Removal of Lead from Water (Bioinorganic Chemistry and Applications (2010) 2010 (603978) DOI: 10.1155/2010/603978)
    Muataz Ali Atieh, Omer Yehya Bakather, Bassam Tawabini, Alaadin A. Bukhari, Faraj Ahmad Abuilaiwi, Mohamed B. Fettouhi
    Bioinorganic Chemistry and Applications, 2018
    [This corrects the article DOI: 10.1155/2010/603978.].
  • Graft copolymerization of methyl acrylate onto date palm fiber and its application in the removal of chromium(III) from water
    Abdalla Mohmoud Abulkibash, Nadir Mohammed Osman, Faraj Ahmad Abuilaiwi
    Desalination and Water Treatment, 2017
    Toxic metals released from untreated industrial effluents can reach the water bodies and affect the aquatic life. These metals can easily enter the food chain and cause health hazards. Ion exchangers have been applied to remove certain ions from the polluted water. A new ion-exchanger was prepared by graft copolymerization of methyl acrylate onto date palm wood fiber in an aqueous solution. Hydrogen peroxide was used as an initiator and ferrous ammonium sulfate as a catalyst. The effects of the amount of the initiator, the amount of the catalyst, the reaction time and the reaction temperature were investigated. A maximum percentage of grafting of 220% and a grafting efficiency of 47% were obtained at a temperature of 90°C, a period of time of 2 h and an amount of 0.15 mmol of the catalyst. The optimum volume of the monomer was 8 mL and the concentration of hydrogen peroxide was 0.03 M. The grafted copolymer was characterized by Fourier transform infrared spectroscopy where a band at 1,730 cm–1 provides strong evidence of the grafting process. The surface morphology of the copolymer was studied using the scanning electron microscopy. The ion-exchanger was prepared by reacting the grafted copolymer with hydroxylamine hydrochloride. This ion-exchanger was applied for the removal of chromium from water.
  • Polypyrrole/carbon nanotube supercapacitorsTechnological advances and challenges
    Adeel Afzal, Faraj A. Abuilaiwi, Amir Habib, Muhammad Awais, Samaila B. Waje, Muataz A. Atieh
    Journal of Power Sources, 2017
  • Investigating the removal of methyl tertiary butyl ether (MTBE) from water using raw and modified fly ash waste materials
    S.B. Adebayo, B.S. Tawabini, M.A. Atieh, F.A. Abuilaiwi, S. Alfadul
    Desalination and Water Treatment, 2016
    Classical techniques for remediation of methyl tertiary butyl ether (MTBE) from contaminated water sources are characterized by inherent limitations due to its unique physical and chemical characteristics, making further remediation researches promising. Fly ash (FA), which is a waste material derived from the combustion of coal or heavy liquid fuel has been reported to show favorable adsorption results with selected metals, dyes, and some organics in aqueous solution. In this study, raw FA, acid-treated FA, and metal oxide (silver, iron, and aluminum) impregnated FA were assessed on a bench scale, for MTBE adsorption in contaminated water system and benchmarked against activated carbon (AC). Results showed that only silver oxide (Ag2O) impregnated FA achieved ~24% removal of MTBE from aqueous solution, while the other tested adsorbent materials achieved <10%. MTBE optimum adsorption was attained after 120 min of contact, and 0.5 g/L dosage of adsorbent. Conversely, silver oxide impregnation of AC...
  • A flexible optical pH sensor based on polysulfone membranes coated with pH-responsive polyaniline nanofibers
    Nedal Abu-Thabit, Yunusa Umar, Elaref Ratemi, Ayman Ahmad, Faraj Ahmad Abuilaiwi
    Sensors Switzerland, 2016
  • Removal of chromium (III) from water by using modified and nonmodified carbon nanotubes
    Muataz Ali Atieh, Omer Yahya Bakather, Bassam S. Tawabini, Alaadin A. Bukhari, Mazen Khaled, Mamdouh Alharthi, Mohammed Fettouhi, Faraj Ahmad Abuilaiwi
    Journal of Nanomaterials, 2010
  • Modification and functionalization of multiwalled carbon nanotube (MWCNT) via fischer esterification
    Arabian Journal for Science and Engineering, 2010
  • Effect of carboxylic functional group functionalized on carbon nanotubes surface on the removal of lead from water
    Muataz Ali Atieh, Omer Yehya Bakather, Bassam Al-Tawbini, Alaadin A. Bukhari, Faraj Ahmad Abuilaiwi, Mohamed B. Fettouhi
    Bioinorganic Chemistry and Applications, 2010
  • Radiation vulcanization of natural rubber latex loaded with carbon nanotubes
    Muataz Ali Atieh, Nazif Nazir, Faridah Yusof, Mohammed Fettouhi, Chantara Thevy Ratnam, Mamdouh Alharthi, Faraj A. Abu‐Ilaiwi, Khalid Mohammed, Adnan Al‐Amer
    Fullerenes Nanotubes and Carbon Nanostructures, 2010
  • Preparation and characterization of polyamidoxime chelating resin from rubberwood fibre-g-polyacrylonitrile
    Faraj A. Abuilaiwi, Muataz Ali Atieh, Mansor B. Ahmad, Nor Azowa Ibrahim, Mohamad Zaki Ab. Rahman, Wan Md. Zin Wan Yunus
    Adsorption Science and Technology, 2009
  • Graft copolymerization of acrylamide onto Oil Palm Empty Fruit Bunch (OPEFB) fiber
    Nor Azowa Ibrahim, Faraj Abu-Ilaiwi, Mohamad Zaki Ab. Rahman, Mansor B. Ahmad, Khairul Zaman M. Dahlan, Wan Md Zin Wan Yunus
    Journal of Polymer Research, 2005
  • Optimized conditions for the grafting reaction of poly(methyl acrylate ) onto rubberwood fiber
    Faraj A Abu‐Ilaiwi, Mansor B Ahmad, Nor Azowa Ibrahim, Mohamad Zaki Ab Rahman, Khairul Zaman Md Dahlan, Wan Md Zin Wan Yunus
    Polymer International, 2004
  • Graft copolymerization of methyl methacrylate onto oil palm empty fruit bunch fiber using H2O2/Fe2+ as an initiator
    Nor Azowa Ibrahim, Wan Md Zin Wan Yunus, Faraj A. Abu‐Ilaiwi, Mohd Zaki Ab Rahman, Mansor Bin Ahmad, Khairul Zaman M. Dahlan
    Journal of Applied Polymer Science, 2003
  • Optimized condition for grafting reaction of poly(butyl acrylate) onto oil palm empty fruit bunch fibre
    NA Ibrahim, WMZ Wan Yunus, FAF Abu‐Ilaiwi, MZA Rahman, MB Ahmad, KZM Dahlan
    Polymer International, 2003
  • Graft copolymerization of methyl methacrylate onto rubber-wood fiber using H2O2 and Fe2+ as an initiator system
    Faraj A. Abu‐Ilaiwi, Mansor B. Ahmad, Nor Azowa Ibrahim, Mohamad Zaki Ab. Rahman, Khairul Zaman Md. Dahlan, Wan Md. Zin Wan Yunus
    Journal of Applied Polymer Science, 2003