Dr. Mahender Khatravath

Scopus Publications

Oxidative Annulations of N-Aryl Glycine Esters: Access to Quinolines and Quinoline-Fused Lactones/Lactams
Vikash Kumar, Ashutosh Dey, Megha Kumari, Rohit Kumar Maurya, Kishor Padala, Mahender Khatravath
Asian Journal of Organic Chemistry, 2026
In recent years, oxidative dehydrogenative transformations such as cross‐dehydrogenative coupling (CDC) and double oxidative dehydrogenative coupling (DOD) or cyclization reactions have emerged as powerful and sustainable methods for the construction of quinolines and quinoline‐fused lactones and lactams from N ‐aryl glycine derivatives. N ‐aryl glycine esters, owing to their dual reactivity, have proven especially versatile in these annulation processes, enabling efficient C─C and C─N bond formation without the need for prefunctionalized substrates. This review highlights recent progress in oxidative methodologies, with an emphasis on mechanistic aspects, catalytic systems, and synthetic applications leading to quinolines and quinoline‐fused lactones/lactams.
Cu-catalyzed oxidative imino Diels–Alder cyclization: synthesis of dihydrofuroquinolines
Vikash Kumar, Ashutosh Dey, Rohit Kumar Maurya, Abhay Kumar Yadav, Megha Kumari, Angad Kumar Singh, Mahender Khatravath
Organic and Biomolecular Chemistry, 2026
A Cu-mediated oxidative cyclization enables rapid assembly of dihydrofuro[3,4-b]quinolines from (2-propargyloxy)acetaldehydes and aromatic amines in good to excellent yields under mild conditions; benzylic oxidation affords quinoline-fused lactones.
Iron photocatalysis in dual catalysis: forming C-C and C-X bonds
Anilkumar Kommoju, Saraswathy Ramalingam, Saikumar Boddepalli, Sabbasani Rajasekhara Reddy, Saratchandra Babu Mukkamala, Mallu Chenna Reddy, Mahender Khatravath, Togati Naveen, Kishor Padala
Chemical Communications, 2025
Iron-based dual photocatalysis offers a green, cost-effective route for C–C and C–X bond formation. Through SET and LMCT pathways, iron enables broad reactivity, sustainability, and efficient visible-light-driven synthesis.
Synthesis of C22-C28 substituted Tetrahydropyran fragment of Eribulin
Mahender Khatravath, Naveen Kumar Mallurwar, Javed Iqbal, Prabhat Arya
Tetrahedron Letters, 2025
Trimethylsilyl Triflate as an Efficient Catalyst for Intramolecular and Intermolecular Carbonyl-Alkyne Metathesis Reactions
Mahender Khatravath, Rohit Kumar Maurya, Ashutosh Dey, Vikash Kumar
Synlett, 2025
Trimethylsilyl triflate has emerged as a powerful and versatile Lewis acid catalyst in organic synthesis, offering high efficiency under mild reaction conditions. It is known for its strong electrophilic activation and is widely used for C–C bond formation, heterocyclic synthesis, and protecting-group transformations. Herein, a straightforward synthesis of various biologically and synthetically important compounds, including 2H-chromenes, coumarins, furans, pyrans, and chalcones, has been achieved through carbonyl–alkyne metathesis reactions with trimethylsilyl triflate as a Lewis acid catalyst.
Cobalt-catalyzed Pauson-Khand synthesis of π-extended tetrahydrocyclopentaquinolinones: photophysical properties and DFT analysis
Ashutosh Dey, Surendra Pothuraju, Rohit Kumar Maurya, Vikash Kumar, Megha Kumari, Kishor Padala, Mahender Khatravath
New Journal of Chemistry, 2025
Cobalt-catalyzed Pauson–Khand reaction enables the synthesis of π-extended tetrahydrocyclopentaquinolinones with strong fluorescence. DFT studies reveal structure–property relationships for potential optoelectronic applications.
Synthesis of Fused Isoxazoles via Intramolecular Nitrile Oxide Cycloaddition
Vikash Kumar, Ashutosh Dey, Rohit Kumar Maurya, Megha Kumari, Mahender Khatravath
Chemistryselect, 2025
We report an efficient and straightforward strategy for the synthesis of substituted dihydrofuro[3,4‐c]isoxazoles and dihydro‐4H‐pyrano[4,3‐c]isoxazoles via intramolecular nitrile oxide cycloaddition (INOC) reactions of aldoximes, employing (diacetoxyiodo)benzene (PIDA/DIB/PhI(OAc)₂) as a single, cost‐effective oxidizing agent. This method enables the practical and economical synthesis of structurally diverse and highly functionalized oxygen‐bridged isoxazole derivatives under mild reaction condition with short reaction time.
A Review on Synthesis of Polyketide Natural Products and Polyketide Building Blocks Based on Hydroxy-Directed Nitrile Oxide Cycloaddition Reaction
Megha Kumari, Ashutosh Dey, Mahender Khatravath
Asian Journal of Organic Chemistry, 2025
Hydroxy‐directed nitrile oxide cycloaddition represents an underexplored strategy, though it is offering the regio, enantio and diastereo selective methods for the formation of isoxazolidines as latent aldol products. This approach offering unique regio‐ and stereoselectivity in constructing complex polyketide frameworks, leveraging hydroxy groups as directing agents, has the potential to expand synthetic methodologies for diverse applications in organic and medicinal chemistry. This review article covers the synthetic reports of polyketide building blocks/ natural products involving Hydroxy‐directed nitrile oxide cycloaddition as the key reaction. We believe that summarizing these methods would grab the attention of chemists who are aware and can explore this unique methodology for the synthesis of complex known polyketide natural products.
Fe3O4 magnetic nanoparticles (MNPs) as an efficient catalyst for allylic oxidation of chromenes to coumarins with TBHP
Rohit Kumar Maurya, Ashutosh Dey, Avanigadda Madhu Niharika, Vikash Kumar, Amarender Goud Burra, Dr. Mahender Khatravath
Journal of Molecular Structure, 2025
Recent Advances on Synthesis of 2H-Chromenes, and Chromenes Fused Hetrocyclic Compounds
Rohit Kumar Maurya, Ashutosh Dey, Vikash Kumara, Mahender Khatravath
Asian Journal of Organic Chemistry, 2024
Chromenes and 2H‐Chromenes are vital components of natural products, pharmaceuticals, and agrochemicals that have captured the attention of researchers worldwide. These heterocyclic compounds represent an essential class of structural scaffolds, and the quest for their synthesis in a mild and straightforward way has gained significant momentum. Chromenes are oxygen‐containing heterocycles that have been widely studied due to their potential medicinal properties. In the last two decades, researchers have made remarkable progress towards the synthesis of chromene based heterocyclic compounds using O‐propargylated benzaldehydes as a substrate. These substrates are highly versatile and contain functional groups that make them ideal for a wide range of reactions. This review article provides an in‐depth analysis of the latest advances in alkynes’ functionalization, emphasizing the substrate scope, limitations, regioselectivity control, and applications of these reactions. The review also covers a range of critical methods and strategies, including multicomponent reactions, used for the general synthesis of numerous types of chromene derivatives.
Silica Sulphuric Acid Catalyzed Intra-Molecular Alkyne Carbonyl Metathesis (ACM): A Rapid Access to 2H-Chromenes
Rohit Kumar Maurya, Vikash Kumar, Ashutosh Dey, Shubham Kumar, Mahender Khatravath
Asian Journal of Organic Chemistry, 2024
PIDA Mediated Synthesis of Benzopyranoisoxazoles via an Intramolecular Nitrile Oxide Cycloaddition (INOC): Application to the Synthesis 4H-chromeno[4,3-c]isoxazol-4-ones.
Rohit Kumar Maurya, Shubham Kumar, Vikash Kumar, Ashutosh Dey, Ravinder Reddy Patlolla, Amarender Goud Burra, Mahender Khatravath
Asian Journal of Organic Chemistry, 2023
Recent Advancements in Synthesis of Phenanthridines via 2-Isocyanobiphenyls
Ashutosh Dey, Vikash Kumar, Rana Chatterjee, Ananya Behera, Rohit Kumar Maurya, Amarender Goud Burra, Shubham Kumar, Mahender Khatravath, Rambabu Dandella
Asian Journal of Organic Chemistry, 2023
Recent progress towards transition-metal-catalyzed arylative cyclization/annulation reactions with boronic acids
Rohit Kumar Maurya, Swadhapriya Bhukta, Keshav Kishor, Rana Chatterjee, Amarender Goud Burra, Mahender Khatravath, Rambabu Dandela
Journal of Molecular Structure, 2023
PLGA-based nanoparticles as regenerative medicine
Deepika Sharma, Smruti Rekha Rout, Gowtham Kenguva, Mahender Khatravath, Gaurav K. Jain, Geeta Aggarwal, Prashant Kesharwani, Rambabu Dandela
Poly Lactic Co Glycolic Acid Plga Nanoparticles for Drug Delivery, 2023
Resonance Photoemission Spectroscopic Study of Thermally Evaporated NiTiO3 Thin Films
N. K. Singh, A. Kumar, R. Dawn, S. Jena, A. Kumari, V. R. Singh, M. Zzaman, R. Shahid, D. Panda, S. K. Sahoo, U. K. Goutam, V. K. Verma, K. Kumar, M. Khatravath, A. Priyam
Journal of Electronic Materials, 2023
Recent Advances in Transition Metal-Catalyzed Domino-Cyclization Strategies for Functionalized Heterocyclic/Carbocyclic Compounds
Rohit Kumar Maurya, Deepika Sharma, Suruchi Kumari, Rana Chatterjee, Mahender Khatravath, Rambabu Dandela
Chemistryselect, 2022
Recent Advancements in Development of Radical Silylation Reactions
Mahender Khatravath, Rohit Kumar Maurya, Ashutosh Dey, Amarender Goud Burra, Rana Chatterjee, Rambabu Dandela
Current Organic Chemistry, 2022
Recent Advances in the Synthesis of Coumarin and Its Derivatives by Using Aryl Propiolates
Deepika Sharma, Vasudevan Dhayalan, Rana Chatterjee, Mahender Khatravath, Rambabu Dandela
Chemistryselect, 2022
Applications of Ethynylanilines as Substrates for Construction of Indoles and Indole-Substituted Derivatives
Omkar S. Kamble, Mahender Khatravath, Rambabu Dandela
Chemistryselect, 2021
Facile access to [1,2]-oxazine derivativesviaannulations of aminoxy-tethered 1,7-enynes
Raji Reddy Chada, Roshan Chandrakant Kajare, Mayur C. Bhandari, Siddique Z. Mohammed, Mahender Khatravath, Kamalkishor Warudikar, Nagender Punna
Organic and Biomolecular Chemistry, 2021
Stereoselective Approaches for Building the C14-C21 Fragment of Eribulin
Naveen Kumar Mallurwar, Mahender Khatravath, Saidulu Konda, Thanusha Thatikonda, Javed Iqbal, Prabhat Arya
Chemistryselect, 2021
Synthesis of C1–C11 eribulin fragment and its diastereomeric analogues
Mahender Khatravath, Naveen Kumar Mallurwar, Saidulu Konda, Jagan Gaddam, Pallavi Rao, Javed Iqbal, Prabhat Arya
Tetrahedron Letters, 2019
Ring-closing metathesis-based methods in chemical biology: Building a natural product-inspired macrocyclic toolbox to tackle protein-protein interactions
Jagan Gaddam, Naveen Kumar Mallurwar, Saidulu Konda, Mahender Khatravath, Madhu Aeluri, Prasenjit Mitra, Prabhat Arya
Practical Medicinal Chemistry with Macrocycles Design Synthesis and Case Studies, 2017
Stereoselective Synthesis of the C27-C35 Eribulin Fragment and Its Utilization in Building Structurally Diverse Macrocycles
Javed Iqbal, Prabhat Arya, Saidulu Konda, Mahender Khatravath, Naveen Mallurwar, Pallavi Rao, Shivashankar Sripelly
Synthesis Germany, 2016
Building a macrocyclic toolbox from C-linked carbohydrates identifies antiangiogenesis agents from zebrafish assay
Srinivas Jogula, Bhanudas Dasari, Mahender Khatravath, Gayathri Chandrasekar, Satish Srinivas Kitambi, Prabhat Arya
European Journal of Organic Chemistry, 2013

RECENT SCHOLAR PUBLICATIONS

Oxidative Annulations of N ‐Aryl Glycine Esters: Access to Quinolines and Quinoline‐Fused Lactones/Lactams
V Kumar, A Dey, M Kumari, RK Maurya, K Padala, M Khatravath
Asian Journal of Organic Chemistry 15 (5), e70446 , 2026
2026
Cu-catalyzed oxidative imino Diels–Alder cyclization: synthesis of dihydrofuroquinolines
V Kumar, A Dey, RK Maurya, AK Yadav, M Kumari, AK Singh, ...
Organic & Biomolecular Chemistry , 2026
2026
Synthesis of C22-C28 substituted Tetrahydropyran fragment of Eribulin
M Khatravath, NK Mallurwar, J Iqbal, P Arya
Tetrahedron Letters 168, 155708 , 2025
2025
Citations: 1
Trimethylsilyl Triflate as an Efficient Catalyst for Intramolecular and Intermolecular Carbonyl–Alkyne Metathesis Reactions
RK Maurya, A Dey, V Kumar, M Khatravath
Synlett 36 (15), 2309-2315 , 2025
2025
Citations: 1
Synthesis of Fused Isoxazoles via Intramolecular Nitrile Oxide Cycloaddition
V Kumar, A Dey, RK Maurya, M Kumari, M Khatravath
ChemistrySelect 10 (17), e202501315 , 2025
2025
Citations: 2
Fe3O4 magnetic nanoparticles (MNPs) as an efficient catalyst for allylic oxidation of chromenes to coumarins with TBHP
RK Maurya, A Dey, AM Niharika, V Kumar, AG Burra, M Khatravath
Journal of Molecular Structure 1322, 140091 , 2025
2025
Citations: 5
Iron photocatalysis in dual catalysis: forming C–C and C–X bonds
A Kommoju, S Ramalingam, S Boddepalli, SR Reddy, SB Mukkamala, ...
Chemical Communications 61 (82), 15930-15952 , 2025
2025
Citations: 3
Cobalt-catalyzed Pauson–Khand synthesis of π-extended tetrahydrocyclopentaquinolinones: photophysical properties and DFT analysis
A Dey, S Pothuraju, RK Maurya, V Kumar, M Kumari, K Padala, ...
New Journal of Chemistry 49 (32), 13950-13957 , 2025
2025
Citations: 1
A Review on Synthesis of Polyketide Natural Products and Polyketide Building Blocks Based on Hydroxy‐Directed Nitrile Oxide Cycloaddition Reaction
M Kumari, A Dey, M Khatravath
Asian Journal of Organic Chemistry, e202400766 , 2025
2025
Citations: 1
Recent Advances on Synthesis of 2H‐Chromenes, and Chromenes Fused Hetrocyclic Compounds
RK Maurya, V Kumar, A Dey, S Kumar, M Khatravath
Asian Journal of Organic Chemistry, e202400259 , 2024
2024
Citations: 20
Silica Sulphuric Acid Catalyzed Intra‐molecular Alkyne Carbonyl Metathesis (ACM): A Rapid Access to 2H‐Chromenes
DMK Rohit Kumar Maurya, Vikash Kumar, Ashutosh Dey, Shubham Kumar
Asian Journal of Organic Chemistry, e202400219 , 2024
2024
Citations: 6
Recent Advancements in Synthesis of Phenanthridines via 2‐Isocyanobiphenyls
A Dey, V Kumar, R Chatterjee, A Behera, RK Maurya, AG Burra, S Kumar, ...
Asian Journal of Organic Chemistry 12 (11), e202300369 , 2023
2023
Citations: 19
PIDA Mediated Synthesis of Benzopyranoisoxazoles via an Intramolecular Nitrile Oxide Cycloaddition (INOC): Application to the Synthesis 4H‐chromeno [4, 3‐c] isoxazol‐4‐ones.
RK Maurya, S Kumar, V Kumar, A Dey, RR Patlolla, AG Burra, ...
Asian Journal of Organic Chemistry 12 (11), e202300410 , 2023
2023
Citations: 13
Recent progress towards transition-metal-catalyzed arylative cyclization/annulation reactions with boronic acids
RK Maurya, S Bhukta, K Kishor, R Chatterjee, AG Burra, M Khatravath, ...
Journal of Molecular Structure 1277, 134760 , 2023
2023
Citations: 7
PLGA-based nanoparticles as regenerative medicine
D Sharma, SR Rout, G Kenguva, M Khatravath, GK Jain, G Aggarwal, ...
Poly (lactic-co-glycolic acid)(PLGA) Nanoparticles for Drug Delivery, 335-356 , 2023
2023
Citations: 4
Resonance Photoemission Spectroscopic Study of Thermally Evaporated NiTiO3 Thin Films
AP N. K. Singh, A. Kumar, R. Dawn, S. Jena, A. Kumari, V. R. Singh, M ...
Journal of Electronic Materials 52, 669–678 , 2023
2023
Citations: 6
Recent Advances in Transition Metal‐Catalyzed Domino‐Cyclization Strategies for Functionalized Heterocyclic/Carbocyclic Compounds
RK Maurya, D Sharma, S Kumari, R Chatterjee, M Khatravath, R Dandela
ChemistrySelect 7 (28), e202201408 , 2022
2022
Citations: 12
Recent advancements in development of radical silylation reactions
M Khatravath, RK Maurya, A Dey, AG Burra, R Chatterjee, R Dandela
Current Organic Chemistry 26 (10), 920-960 , 2022
2022
Citations: 19
Recent advances in the synthesis of coumarin and its derivatives by using aryl propiolates
D Sharma, V Dhayalan, R Chatterjee, M Khatravath, R Dandela
ChemistrySelect 7 (4), e202104299 , 2022
2022
Citations: 20
Applications of Ethynylanilines as Substrates for Construction of Indoles and Indole‐Substituted Derivatives
OS Kamble, M Khatravath, R Dandela
ChemistrySelect 6 (29), 7408-7427 , 2021
2021
Citations: 17

MOST CITED SCHOLAR PUBLICATIONS

Practical medicinal chemistry with macrocycles
E Marsault, ML Peterson
John Wiley & Sons, Incorporated , 2017
2017
Citations: 62
Recent Advances on Synthesis of 2H‐Chromenes, and Chromenes Fused Hetrocyclic Compounds
RK Maurya, V Kumar, A Dey, S Kumar, M Khatravath
Asian Journal of Organic Chemistry, e202400259 , 2024
2024
Citations: 20
Recent advances in the synthesis of coumarin and its derivatives by using aryl propiolates
D Sharma, V Dhayalan, R Chatterjee, M Khatravath, R Dandela
ChemistrySelect 7 (4), e202104299 , 2022
2022
Citations: 20
Recent Advancements in Synthesis of Phenanthridines via 2‐Isocyanobiphenyls
A Dey, V Kumar, R Chatterjee, A Behera, RK Maurya, AG Burra, S Kumar, ...
Asian Journal of Organic Chemistry 12 (11), e202300369 , 2023
2023
Citations: 19
Recent advancements in development of radical silylation reactions
M Khatravath, RK Maurya, A Dey, AG Burra, R Chatterjee, R Dandela
Current Organic Chemistry 26 (10), 920-960 , 2022
2022
Citations: 19
Building a Macrocyclic Toolbox from C ‐Linked Carbohydrates Identifies Antiangiogenesis Agents from Zebrafish Assay
S Jogula, B Dasari, M Khatravath, G Chandrasekar, SS Kitambi, P Arya
European Journal of Organic Chemistry 2013 (23), 5036-5040 , 2013
2013
Citations: 19
Applications of Ethynylanilines as Substrates for Construction of Indoles and Indole‐Substituted Derivatives
OS Kamble, M Khatravath, R Dandela
ChemistrySelect 6 (29), 7408-7427 , 2021
2021
Citations: 17
PIDA Mediated Synthesis of Benzopyranoisoxazoles via an Intramolecular Nitrile Oxide Cycloaddition (INOC): Application to the Synthesis 4H‐chromeno [4, 3‐c] isoxazol‐4‐ones.
RK Maurya, S Kumar, V Kumar, A Dey, RR Patlolla, AG Burra, ...
Asian Journal of Organic Chemistry 12 (11), e202300410 , 2023
2023
Citations: 13
Facile access to [1, 2]-oxazine derivatives via annulations of aminoxy-tethered 1, 7-enynes
RR Chada, RC Kajare, MC Bhandari, SZ Mohammed, M Khatravath, ...
Organic & Biomolecular Chemistry 19 (4), 809-821 , 2020
2020
Citations: 13
Recent Advances in Transition Metal‐Catalyzed Domino‐Cyclization Strategies for Functionalized Heterocyclic/Carbocyclic Compounds
RK Maurya, D Sharma, S Kumari, R Chatterjee, M Khatravath, R Dandela
ChemistrySelect 7 (28), e202201408 , 2022
2022
Citations: 12
Stereoselective Synthesis of the C27–C35 Eribulin Fragment and Its Utilization in Building Structurally Diverse Macrocycles
S Konda, M Khatravath, NK Mallurwar, P Rao, S Sripelly, J Iqbal, P Arya
Synthesis 48 (11), 1663-1683 , 2016
2016
Citations: 9
Recent progress towards transition-metal-catalyzed arylative cyclization/annulation reactions with boronic acids
RK Maurya, S Bhukta, K Kishor, R Chatterjee, AG Burra, M Khatravath, ...
Journal of Molecular Structure 1277, 134760 , 2023
2023
Citations: 7
Synthesis of C1–C11 eribulin fragment and its diastereomeric analogues
M Khatravath, NK Mallurwar, S Konda, J Gaddam, P Rao, J Iqbal, P Arya
Tetrahedron Letters 60 (37), 150915 , 2019
2019
Citations: 7
Silica Sulphuric Acid Catalyzed Intra‐molecular Alkyne Carbonyl Metathesis (ACM): A Rapid Access to 2H‐Chromenes
DMK Rohit Kumar Maurya, Vikash Kumar, Ashutosh Dey, Shubham Kumar
Asian Journal of Organic Chemistry, e202400219 , 2024
2024
Citations: 6
Resonance Photoemission Spectroscopic Study of Thermally Evaporated NiTiO3 Thin Films
AP N. K. Singh, A. Kumar, R. Dawn, S. Jena, A. Kumari, V. R. Singh, M ...
Journal of Electronic Materials 52, 669–678 , 2023
2023
Citations: 6
Stereoselective Approaches for Building the C14‐C21 Fragment of Eribulin
N Kumar Mallurwar, M Khatravath, S Konda, T Thatikonda, J Iqbal, P Arya
ChemistrySelect 6 (4), 798-801 , 2021
2021
Citations: 6
Fe3O4 magnetic nanoparticles (MNPs) as an efficient catalyst for allylic oxidation of chromenes to coumarins with TBHP
RK Maurya, A Dey, AM Niharika, V Kumar, AG Burra, M Khatravath
Journal of Molecular Structure 1322, 140091 , 2025
2025
Citations: 5
PLGA-based nanoparticles as regenerative medicine
D Sharma, SR Rout, G Kenguva, M Khatravath, GK Jain, G Aggarwal, ...
Poly (lactic-co-glycolic acid)(PLGA) Nanoparticles for Drug Delivery, 335-356 , 2023
2023
Citations: 4
Iron photocatalysis in dual catalysis: forming C–C and C–X bonds
A Kommoju, S Ramalingam, S Boddepalli, SR Reddy, SB Mukkamala, ...
Chemical Communications 61 (82), 15930-15952 , 2025
2025
Citations: 3
Synthesis of Fused Isoxazoles via Intramolecular Nitrile Oxide Cycloaddition
V Kumar, A Dey, RK Maurya, M Kumari, M Khatravath
ChemistrySelect 10 (17), e202501315 , 2025
2025
Citations: 2

Dr. Mahender Khatravath

RESEARCH, TEACHING, or OTHER INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS