Nutritionist - University of Alfenas - Brazil
Masters in Nutritional Sciences - Federal University of Viçosa - Brazil
Ph.D. in Clinical Medicine - University of Campinas - Brazil
Pos-doc 1 in Clinical Sciences - University of Campinas - Brazil
Pós-doc 2 in Populational genomics - University of California - Berkeley
Current: Associate Profesor at the University of Campinas - Brazil
RESEARCH, TEACHING, or OTHER INTERESTS
Endocrinology, Diabetes and Metabolism, Biochemistry, Genetics and Molecular Biology, Cellular and Molecular Neuroscience, Health Professions
Changes in weight and metabolic health during and after cessation of a time-restricted feeding plus aerobic training in Swiss mice fed a high-fat diet Renan Fudoli Lins Vieira, Susana Castelo Branco Ramos Nakandakari, Gabriel Calheiros Antunes, Ana Paula Azevedo Macedo, Robson Damasceno de Lima, et al. American Journal of Physiology Endocrinology and Metabolism, 2026 This study demonstrates that combining time-restricted feeding with aerobic training improves weight and metabolic health in Swiss mice fed a high-fat diet. Importantly, we show that most metabolic benefits are lost after intervention cessation. However, insulin sensitivity and aspects of hepatic lipid metabolism are partially maintained after cessation of the intervention. These findings provide new insight into the durability of metabolic improvements induced by lifestyle interventions and highlight the potential of combined dietary and exercise strategies to counteract diet-induced obesity and metabolic dysfunction.
Supplementation with GPR120 (Ffar4) ligand omega-3 does not improve survival in murine sepsis models Susana Castelo Branco Ramos Nakandakari, Eric Isaac Elliott, Renan Fudoli Lins Vieira, Thaiane da Silva Rios, Andin Fosam, et al. American Journal of Physiology Endocrinology and Metabolism, 2025 This study uncovers worsening in survival in mice models pretreated with omega-3 supplementation. We demonstrated decreased Ffar4 receptor expression in macrophages and adipocytes when challenged with acute and chronic sepsis models in vitro and in vivo. This study offers insight into the role of omega-3 supplementation in the context of sepsis, highlighting concerns and underscoring the need for further investigation.
Therapeutic Effect of Alpha Linolenic Acid on Cutaneous Wound Healing in Hyperglycemic Mice: Involvement of Neurotrophins Thais Paulino do Prado, Flávia Cristina Zanchetta, Aline Cristina Rosa Maria, Thaiane da Silva Rios, Guilherme Rossi de Assis-Mendonça, et al. Pharmaceutics, 2025 Background: Alpha-linolenic acid (ALA) is an essential fatty acid from the omega-3 family that plays an important role in skin homeostasis. It is known for its anti-inflammatory properties, which can contribute to wound healing. Neurotrophins, such as Brain-Derived Neurotrophic Factor (BDNF), may also play an important role in the skin, influencing nerve regeneration and pain modulation. Objectives: This article aims to explore the therapeutic effect of ALA on wound healing in streptozotocin-induced hyperglycemic mice, with an emphasis on the involvement of neurotrophins. Methods: We used keratinocyte cultures exposed or not to ALA and male C57BL6-J mice, which were randomly divided into four groups: non-hyperglycemic treated with vehicle; non-hyperglycemic treated with ALA; hyperglycemic treated with vehicle; and hyperglycemic treated with ALA. The treatment was administered continuously via a subcutaneous osmotic pump. Results: We found that controlled ALA administration potentiates the wound healing process in hyperglycemic mice by accelerating the inflammatory phase and promoting early granulation tissue formation (73.2% ± 0.7 vs. 92.2% ± 2.8 on day 7, n = 5; p < 0.05). This is supported by the balance between the expression of vimentin, CD31, and MMP-9. Furthermore, ALA modulates proteins linked to peripheral neurogenesis and gliogenesis, such as BDNF, NTRK2, SOX-10, CNTF, CTNFR, and STAT-3. It may also promote wound healing and nerve regeneration at the wound site in hyperglycemic animals. In non-hyperglycemic mice, ALA improves the quality of scars but does not accelerate the wound healing process, even with the positive modulation of certain genes relevant to skin healing. Conclusions: Alpha-linolenic acid improves skin wound healing and increases gene expression related to nerve regeneration in wounds of hyperglycemic mice.
Green Coffee Extract (Coffea canephora) Administered as Treatment Modulates Hepatic Markers and Attenuates Hepatic Steatosis in Rats Fed a High-Fat Diet Manuella Domiciano do Nascimento, Natália Alves de Souza Meneguelli, Thainara Queiroz Pereira, Neuza Maria Brunoro Costa, Mirelle Lomar Viana, et al. Molecular Nutrition and Food Research, 2025 Green coffee is rich in bioactive compounds with antioxidant and antiinflammatory properties. This study evaluated the effect of green coffee extract (Coffea canephora), as treatment or prevention, on metabolic alterations and morphology of liver and adipose tissue pad in rats fed a high‐fat diet (HF). Forty‐eight male Wistar rats (Rattus norvegicus) were divided into four groups: normocaloric diet (CT), HF, high‐fat diet with green coffee extract as prevention (HFP), or as treatment (HFT). Two‐milliliter of green coffee extract per day per animal was added to the diet. Intraperitoneal glucose tolerance test, inflammatory and oxidative markers analyses, and histological analyses of liver and adipose tissue were performed. The green coffee extract, as treatment or prevention, did not affect food intake, weight gain or oxidative and inflammatory profile of liver and adipose tissue, or adipose tissue pad morphology (p > 0.05). However, the HFT group decreased the concentration of aspartate aminotransferase (AST), increased high‐density lipoprotein (HDL‐c), and reduced severity of hepatic steatosis verified by lower lipid accumulation in the liver (p < 0.05). The green coffee extract as a treatment may benefit liver health in conditions of obesity, modulating hepatic markers and attenuating hepatic steatosis, suggesting its potential as an adjuvant in treating metabolic alterations.
Time-restricted feeding combined with exercise improves hepatic and glycaemic metabolism in obese mice: A sex-dependent study Gabriel Calheiros Antunes, Camila Venturini Ayres Cunha, Leandro Kansuke Oharomari, Renan Fudoli Lins Vieira, Maura Fanti, et al. Journal of Physiology, 2025 Erratic feeding patterns, such as those experienced by shift workers, can exacerbate obesity and metabolic‐associated fatty liver disease (MAFLD). Both nutritional factors and sexual dimorphism influence the progression of MAFLD. Time‐restricted feeding (TRF) has emerged as a promising strategy to mitigate the effects of obesity, supported by evidence of its benefits for metabolic disorders like MAFLD. Regular physical exercise is also recommended as a non‐pharmacological approach to combat obesity and its related conditions. Both TRF and exercise independently show promise in improving metabolic health, weight management and glycaemic control. Thus, combining these approaches may offer a more effective strategy against obesity and MAFLD. In this study, male and female C57BL/6J mice were subjected to an 8‐week obesity induction protocol, followed by TRF (16/8) or TRF combined with aerobic exercise. The results showed that TRF, even during the inactive phase of the mice, had positive effects on weight loss, adiposity, glycaemic homeostasis, insulin sensitivity, liver lipid composition, hepatic fat accumulation and the reduction of lipogenic and inflammatory genes in the liver. The combination of TRF with aerobic exercise provided additional benefits, including improved regulation of hepatic triglycerides and respiratory exchange ratio (RER) in males, enhanced fasting glucose levels in females and reduced Fatp4 gene expression in both sexes. Aerobic exercise performance also improved in both sexes, with males achieving superior results. Notably, the combination of TRF with aerobic exercise provided greater metabolic benefits, with sex‐specific differences observed in metabolic responses. imageKey points Eight weeks of western diet induced obesity, an impaired glucose homeostasis and increased hepatic fat accumulation in male and female C57BL/6J mice. Time‐restricted feeding (TRF) 16/8 in the active phase and TRF combined with aerobic exercise reduced weight gain and metabolic disorders in C57BL/6J male and female mice fed a western diet. TRF when combined with aerobic exercise displayed more pronounced improvements in the hepatic metabolism. TRF when combined with aerobic exercise improved liver triglycerides and respiratory exchange ratio in males, fasting glucose in females and decreased lipogenic gene Fatp4 expression in both males and females.
Omega-3 pleiad: The multipoint anti-inflammatory strategy Ellencristina da Silva Batista, Susana Castelo Branco Ramos Nakandakari, Adelino Sanchez Ramos da Silva, José Rodrigo Pauli, Leandro Pereira de Moura, et al. Critical Reviews in Food Science and Nutrition, 2024
