Giuseppe Gritti

Scopus Publications

Correction: Brentuximab vedotin plus chemotherapy for the treatment of front-line systemic anaplastic large cell lymphoma: subgroup analysis of the ECHELON-2 study at 5 years’ follow-up (Blood Cancer Journal, (2025), 15, 1, (129), 10.1038/s41408-025-01329-2)
Eva Domingo-Domènech, Barbara Pro, Tim Illidge, Steven Horwitz, Lorenz Trumper, Swami Iyer, Ranjana Advani, Nancy L. Bartlett, Jacob Haaber Christensen, Won-Seog Kim, Tatyana Feldman, Ilseung Choi, Giuseppe Gritti, David Belada, Andrei Shustov, Arpad Illes, Pier Luigi Zinzani, Andreas Hüttmann, Marek Trneny, Steven Le Gouill, Deepa Jagadeesh, Jonathan W. Friedberg, Meredith Little, Cassie Dong, Michelle Fanale, Keenan Fenton, Kerry J. Savage
Blood Cancer Journal, 2026
Following the publication of this article, the authors noted the following sentence could be misinterpreted: 'In patients with ALK-sALCL, the estimated 5-year PFS rate (95% CI) was 56.8% (40.5-70.2%)and 56.0%(39.3-69.7%) in the A + CHP and CHOP arms, respectively'.This sentence is in fact about patients with ALK-sALCL who achieved a complete response (CR), and while the sentence appears in the context of a paragraph discussing patients with a CR, the following correction has been made to avoid confusion: 'In patients with ALK-sALCL who achieved CR, the estimated 5-year PFS rate (95% CI) was 56.8% (40.5-70.2%)and 56.0%(39.3-69.7%) in the A + CHP and CHOP arms, respectively'.Data showing 5-year PFS in patients with ALKdisease, regardless of response, appear in Figure 1.
Polatuzumab Vedotin and Glofitamab for Relapsed/Refractory Diffuse Large B-Cell Lymphoma in the Compassionate Use Program in Italy
Pier Luigi Zinzani, Giulia Dell’Omo, Letizia Fusco, Ilaria Peduto, Carlotta Galeone, Federica Cavallo, Giuseppe Gritti
Hematological Oncology, 2026
Compassionate Use Programs (CUP) offers patients with severe diseases, early access to promising new drugs outside of clinical trial and prior to marketing approval. Data arising from CUP provides valuable insights on treatment pathways. In the last few years, the treatment landscape for relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL) has rapidly evolved based on the approval of several novel therapies, resulting in changing treatment patterns which benefit from assessment of modern retrospective data. To address this, we retrospectively evaluated data of two large patient cohorts of r/r DLBCL within the polatuzumab vedotin and glofitamab Roche Global CUP opened in Italy [1], as was done in similar studies from other European countries [2, 3]. In fact, this analysis did not evaluate the effectiveness of the two products, that has been recently reported for polatuzumab vedotin [4]. The polatuzumab vedotin-rituximab +/− bendamustine CUP cohort included r/r DLBCL patients after at least 2 lines of treatment; with 208 patient requests received from 92 national centers between May 2019 and April 2020. The glofitamab CUP cohort included patients with r/r DLBCL, high-grade B-cell lymphoma (HGBCL) or primary mediastinal B cell lymphoma (PMBCL) after at least 3 lines of previous treatments; with 145 patient requests received from 59 national centers between March 2022 and April 2024. Cohort characteristics were compared using the Chi-square or Fisher's exact test for categorical data, and the Wilcoxon rank-sum test for continuous data. Clinical characteristics of the patient population are summarized in Table 1. Both cohorts showed a prevalence of males. The median age (minimum-maximum range) at diagnosis was higher in the polatuzumab vedotin-rituximab +/− bendamustine cohort (63 years; range: 24–84 years) compared to the glofitamab cohort (60 years; range: 17–82 years, p-value = 0.002). Similarly, the median age at CUP request was higher in the polatuzumab vedotin-rituximab +/− bendamustine (67 years; range: 25–85 years) than in the glofitamab cohort (62 years; range: 19–85 years, p-value < 0.001). The median duration from diagnosis to CUP request was comparable in the two cohorts (median 2 years, range 0–22). In the polatuzumab vedotin cohort, 78% patients were previously treated with 2 (49%) or 3 (29%) lines of treatment, whereas the glofitamab cohort had 79% of patients previously treated with 3 (34%) or 4 (45%) lines of treatment (p-value = 0.004). Total N = 353 Polatuzumab vedotin N = 208 Glofitamab N = 145 Treatment courses experienced by patients across the two cohorts are depicted in Figure 1. In the polatuzumab vedotin-rituximab +/− bendamustine cohort (Figure 1A), the most frequent frontline regimen was R-CHOP (66%), followed by R-CHOP like (e.g., R-COMP, R-COMP + rituximab, R-BENDA, etc; 23%) and by R-CHOP dose-dense chemotherapy (e.g., DA-EPOCH-R, MACOP-B, etc; 10%). The corresponding distribution in the glofitamab cohort (Figure 1B) was 59%, 17% and 24%, respectively. In both cohorts the use of R-CHOP dose-dense chemotherapy was more frequent in younger patients (median age: 51 years, range: 33–78 years in the polatuzumab vedotin-rituximab +/− bendamustine cohort; median age: 54 years, range: 17–72 years in the glofitamab cohort) as compared to R-CHOP standard-dose regimen (median age: 63 years, range: 24–83 years in the polatuzumab vedotin-rituximab +/− bendamustine cohort; median age: 59 years, range: 17–83 years in the glofitamab cohort). Sankey diagram reporting treatment flow of patients before entering polatuzumab vedotin (Panel A) and glofitamab (Panel B) compassionate use programs. In second line, in the polatuzumab vedotin-rituximab +/− bendamustine cohort, we observed that 63% of patients were treated with high dose chemotherapy and stem cell transplantation (SCT), at a median age of 61 years (range: 24–78 years), whereas in the glofitamab cohort the corresponding percentage was 75% and the median age was 57 years (range: 18–76 years). In both cohorts, the use of second-line chemo-free regimens was limited (< 10%) and was mainly reserved for older patients, with a median age of 73 years in both the polatuzumab vedotin-rituximab +/− bendamustine (range: 60–82 years) and glofitamab cohorts (range: 18–84 years). Third line treatment significantly differed in the two cohorts due to the different period observed that is, 2019–20 in the polatuzumab vedotin-rituximab +/− bendamustine and 2022–24 in the glofitamab cohort. In the polatuzumab vedotin-rituximab +/− bendamustine cohort, 28% of cases were treated with high dose chemotherapy and SCT, and 26% with chemo-free regimens, while in the glofitamab cohort 33% of patients were treated with polatuzumab vedotin, 28% with CAR-T therapy, and 15% each with high dose chemotherapy and SCT or chemo-free regimens. The two CUPs generated data to observe the treatment pathways of r/r DLBCL in Italy in two different time periods. A significant shift toward use of novel immunotherapies (primarily, polatuzumab vedotin and CAR-T), particularly after two lines of treatment, emerged in the descriptive analyses of the two cohorts. Earlier Italian data from the STRIDER study which evaluated first and second line therapy in DLBCL patients from 2010–2019 reported use of lenalidomide, platinum-based regimens, investigational drugs and other various regimens in third line of treatment [5], highlighting the urgency for widespread approval of novel treatments such as CAR-T cells and bispecific antibodies as second-line to improve r/r DLBCL patients outcomes. Moreover the commercial availability of CAR-T cell therapy (November 2019 Yescarta) and polatuzumab vedotin (January 2022) has been captured our observation (Sankey Diagram, Figure 1). Consistent with what was observed in the glofitamab cohort, recent data from the European transplant registry confirms that the use of high dose chemotherapy and SCT is progressively declining with the availability of new immunotherapies [6]. The current therapeutic landscape is also rapidly evolving, with second-line CAR-T therapy and first-line pola-R-CHP now established standards of care. Due to the temporal constraints of our cohorts and the requirement of ≥ 3 prior treatment lines for CUP eligibility, our dataset cannot yet reflect the impact of these recent advances on treatment sequencing, thus limiting the relevance of the observed sequencing in the current clinical practice. In conclusion, it provided insights into the evolving treatment pathways in Italy across two distinct time periods, showing the shift toward earlier use of novel immunotherapies. This approach may serve as a valuable complement to traditional data-generation methods, enhancing the understanding of treatment sequencing in patients with r/r DLBCL within a rapidly evolving therapeutic landscape. The authors gratefully acknowledge Pier Luigi Zinzani, Federica Cavallo and Giuseppe Gritti for their valuable contribution of expertise and time towards the interpretation of the results and the critical review of this manuscript without financial compensation. The retrospective analysis was sponsored by Roche SpA. Pier Luigi Zinzani: Consultant for MSD, Takeda, Recordati, Novartis, Speakers bureau for Sobi, Kite-Gilead, Janssen, BMS, MSD, AstraZeneca, Takeda, Roche, Recordati, Kyowa Kirin, Novartis, Incyte, Beigene, Advisory Board for Sobi, Kite-Gilead, Janssen, BMS, MSD, AstraZeneca, Takeda, Roche, Recordati, Kyowa Kirin, Novartis, ADC Therap., Incyte, Beigene; Giulia Dell’Omo, Letizia Fusco and Ilaria Peduto are employees of Roche SpA; Carlotta Galeone performed statistical analysis for Roche; Federica Cavallo: Advisory Board for Roche, Speakers fee and Research grant from Roche; Giuseppe Gritti: Advisory Board for Abbvie, Roche, Takeda, Kite-Gilead, Genmab, Speaker's bureau for Takeda, Ideogen, Genmab, Support for attending meetings from Kite-Gilead, Janssen, Research support from Ideogen. The datasets generated and/or analyzed are available from the corresponding author on reasonable request. For up-to-date details on Roche's Global Policy on the Sharing of Clinical Information and how to request access to related documents, see here: go.roche.com/data_sharing.
Pirtobrutinib in relapsed or refractory mantle cell lymphoma: outcomes from the compassionate use program in Italy
Daniela Estefania Banegas, Isacco Ferrarini, Andrea Bernardelli, Alessia Moioli, Vittorio Ruggero Zilioli, Luca Nassi, Chiara Rusconi, Beatrice Casadei, Cinzia Pellegrini, Guido Gini, Giuseppe Gritti, Giulia Daghia, Elsa Pennese, Luigi Petrucci, Simone Ferrero, Sonya De Lorenzo, Sara Veronica Usai, Ausilia Gorgone, Massimo Gentile, Alessia Castellino, Anna Vanazzi, Luigi Curreli, Lucia Morello, Monica Tani, Daniela Renzi, Brunella Mola, Alberto Fabbri, Alfredo Molteni, Roberta Sciarra, Pier Luigi Zinzani, Carlo Visco
Leukemia and Lymphoma, 2026
MCL is a rare subtype of B-cell non-Hodgkin lymphoma, accounting for approximately 5–7% of all lymphomas and showing a higher prevalence in males. MCL is characterized by the expression of CD5 and ...
Association of PET4 response with outcomes of BV-CHP vs CHOP in the ECHELON-2 trial in CD30+ peripheral T-cell lymphoma
Swaminathan Iyer, Neha Mehta-Shah, Ranjana Advani, Nancy L. Bartlett, Jacob H. Christensen, Franck Morschhauser, Eva Domingo-Domenech, Giuseppe Rossi, Won Seog Kim, Onder Alpdogan, Tatyana A. Feldman, Vincent Camus, Giuseppe Gritti, Pier Luigi Zinzani, David Belada, Jiri Mayer, Ilseung Choi, June-Won Cheong, Evelyn Rustia, Keenan Fenton, Michelle Fanale, Kerry J. Savage, Steven M. Horwitz
Blood Advances, 2025
In the phase 3 ECHELON-2 trial, brentuximab vedotin, cyclophosphamide, doxorubicin, and prednisone (BV-CHP) significantly improved progression-free survival (PFS) and overall survival (OS) compared with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in patients with CD30+ peripheral T-cell lymphoma, benefits that were maintained at 5 years. Interim positron emission tomography (PET) scan can be used to assess prognosis and risk-stratify patients. The prognostic value of interim PET was assessed in this post hoc exploratory analysis from ECHELON-2, evaluating interim 18F-fluorodeoxyglucose PET scans after cycle 4 (PET4) and end-of-treatment–based response, and correlated with PFS per investigator and OS. PET4 response was determined by Deauville score (scores of 1-3 were considered negative [PET4-negative] and 4-5 positive [PET4-positive]) by independent review. Overall, 452 patients were randomized 1:1 to the BV-CHP (n = 226) and CHOP (n = 226) arms. Of these, 32 in the BV-CHP arm and 41 in the CHOP arm were not evaluable for PET4. In both arms, PET4-negative status was associated with improved PFS (BV-CHP: HR, 0.36; 95% CI, 0.19-0.66; CHOP: HR, 0.26; 95% CI, 0.17-0.41) and OS (BV-CHP: HR, 0.38; 95% CI, 0.18-0.78; CHOP: HR, 0.24; 95% CI, 0.14-0.41) compared with PET4-positive status. Among patients with systemic anaplastic large cell lymphoma, PET4-negative patients had improved PFS (BV-CHP: HR, 0.28; 95% CI, 0.14-0.60; CHOP: HR, 0.31; 95% CI, 0.17-0.56) and OS (BV-CHP: HR, 0.38; 95% CI, 0.16-0.94; CHOP: HR, 0.25; 95% CI, 0.12-0.55) compared with PET4-positive patients. In this exploratory analysis, PET4-negative status by Deauville score was associated with improved long-term PFS and OS in both the BV-CHP and CHOP arms. This trial was registered at www.ClinicalTrials.gov as #NCT01777152.
Efficacy and Safety of Glofitamab Plus Polatuzumab Vedotin in Relapsed/Refractory Large B-Cell Lymphoma Including High-Grade B-Cell Lymphoma: Results From a Phase Ib/II Trial
Martin Hutchings, Anna Sureda, Francesc Bosch, Thomas Stauffer Larsen, Paolo Corradini, Abraham Avigdor, María José Terol, Antonio Rueda Dominguez, Antonio Pinto, Alan Skarbnik, Raul Cordoba, Judit Meszaros Jørgensen, Pier Luigi Zinzani, Wilfred Leung, Alessia Bottos, Donghang Li, James Relf, Maneesh Tandon, Gila Sellam, Giuseppe Gritti
Journal of Clinical Oncology, 2025
PURPOSE An unmet need remains for more effective therapies for relapsed/refractory (R/R) large B-cell lymphoma (LBCL), especially high-grade B-cell lymphoma (HGBCL). We present the primary analysis of a phase Ib/II study (ClinicalTrials.gov identifier: NCT03533283 ) investigating efficacy and safety of glofitamab plus polatuzumab vedotin (Glofit-Pola) in patients with R/R LBCL, including HGBCL and those who received previous chimeric antigen receptor (CAR) T-cell therapy. METHODS Patients received 1,000 mg obinutuzumab on Cycle (C)1 Day (D)1 (once daily). Polatuzumab vedotin (1.8 mg/kg) was given on C1D2 and D1 of C2–6 (21-day cycles; once daily). Glofitamab was given as step-up doses in C1 (D8, 2.5 mg; D15, 10 mg) followed by 30 mg on D1 of C2–12 (21-day cycles; once daily). Polatuzumab vedotin was given for six fixed-duration cycles, and glofitamab for 12. RESULTS As of September 2, 2024, 129 patients with LBCL (HGBCL; n = 44, 34.1%), received ≥1 dose of study treatment. The median age was 67 years (range, 23-84), and 63.6% were male. Patients had received a median of 2 (range, 1-7) previous lines of treatment (previous CAR T-cell therapy, n = 28, 21.7%). The independent review committee–assessed overall response rate was 78.3% (complete response rate, 59.7%). The median progression-free survival and overall survival (OS) were 12.3 and 33.8 months, respectively (median OS follow-up time, 32.7 months). The most common adverse event (AE) was cytokine release syndrome (43.4%; grade 1-2: 41.9%; one grade 5 event). Grade 3-4 AEs occurred in 58.9% of patients; 9.3% had grade 5 AEs, and 14.7% discontinued treatment because of AEs. CONCLUSION Glofit-Pola demonstrated high efficacy and durable responses, with manageable safety, in heavily pretreated patients with R/R LBCL, including patients with HGBCL and previous CAR T-cell therapy failure.
Brentuximab vedotin plus chemotherapy for the treatment of front-line systemic anaplastic large cell lymphoma: subgroup analysis of the ECHELON-2 study at 5 years’ follow-up
Eva Domingo-Domènech, Barbara Pro, Tim Illidge, Steven Horwitz, Lorenz Trumper, Swami Iyer, Ranjana Advani, Nancy L. Bartlett, Jacob Haaber Christensen, Won-Seog Kim, Tatyana Feldman, Ilseung Choi, Giuseppe Gritti, David Belada, Andrei Shustov, Arpad Illes, Pier Luigi Zinzani, Andreas Hüttmann, Marek Trneny, Steven Le Gouill, Deepa Jagadeesh, Jonathan W. Friedberg, Meredith Little, Cassie Dong, Michelle Fanale, Keenan Fenton, Kerry J. Savage
Blood Cancer Journal, 2025
Trial registration: ClinicalTrials.gov number: NCT01777152
Donor-derived CARCIK-CD19 cells engineered with Sleeping Beauty transposon in acute lymphoblastic leukemia relapsed after allogeneic transplantation
Federico Lussana, Chiara F. Magnani, Stefania Galimberti, Giuseppe Gritti, Giuseppe Gaipa, Daniela Belotti, Benedetta Cabiati, Sara Napolitano, Silvia Ferrari, Alex Moretti, Chiara Buracchi, Gian Maria Borleri, Benedetta Rambaldi, Giuliana Rizzuto, Anna Grassi, Muriel Paganessi, Cristian Meli, Sarah Tettamanti, Giulia Risca, Giulia Pais, Giulio Spinozzi, Fabrizio Benedicenti, Giovanni Cazzaniga, Chiara Capelli, Elisa Gotti, Martino Introna, Josée Golay, Eugenio Montini, Adriana Balduzzi, Maria Grazia Valsecchi, Giuseppe Dastoli, Alessandro Rambaldi, Andrea Biondi
Blood Cancer Journal, 2025
Non-viral engineering can ease CAR-T cell production and reduce regulatory and cost requirements. We utilized Sleeping Beauty transposon to engineer donor-derived anti-CD19.CD28.OX40.CD3zeta T cells differentiated in cytokine-induced killer (CARCIK-CD19) for B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients relapsed after allogeneic hematopoietic stem cell transplantation (alloHSCT). We report the results of CARCIK-CD19 observed in 36 patients (4 children and 32 adults) treated according to the final recommended dose. Cytokine release syndrome of grade 2 or lower occurred in 15 patients, ICANS grade 2 in 1 patient, and late-onset peripheral neurotoxicity of grade 3 in 2 patients. GVHD never occurred after treatment with allogeneic CARCIK-CD19. Complete remission was achieved by 30 out of 36 patients (83.3%), with MRD negativity in 89% of responders. With a median follow-up of 2.2 years, the 1-year overall survival was 57.0%, and event-free survival was 32.0%. The median duration of response at 1 year was 38.6%. CAR-T cells expanded rapidly after infusion and remained detectable for over 2 years. Integration site analysis after infusion showed a high clonal diversity. These data demonstrated that SB-engineered CAR-T cells are safe and induce durable remission in heavily pretreated patients with BCP-ALL relapsed after alloHSCT. Trial registration: The phase 1/2 and phase II trials are registered at www.clinicaltrials.gov as NCT#03389035 and NCT#05252403.
Enhancing the diagnostic accuracy of core needle biopsy in patients with lymphoproliferative disorders by an optimized protocol
Silvia Ferrari, Alessandra Weber, Paolo Marra, Paola Tebaldi, Chiara Pavoni, Anna Maria Barbui, Giuseppe Gritti, Ludovico Dulcetta, Francesco Saverio Carbone, Riccardo Muglia, Paola Anna Erba, Andrea Gianatti, Alessandro Rambaldi, Sandro Sironi
Radiologia Medica, 2025
Purpose Surgical excision biopsy of lymph nodes stands as the gold standard for histological characterization of lymphoproliferative disorders (LD). However, contemporary clinical practice increasingly leans toward core needle biopsy (CNB). This study seeks to explore the factors influencing the diagnostic yield of CNB in LD. Material and Methods This unicentric retrospective study presents data from patients referred for suspicion of new or relapsing LD. All patients underwent image-guided CNB of the target lesion based on PET/CT findings. The primary endpoint was the diagnostic outcome, comparing the ability to achieve a definitive diagnosis according to international guidelines with CNB versus the necessity for subsequent excisional biopsy. Results We enrolled 478 consecutive patients undergoing CNB, categorized into two cohorts. Cohort A comprised patients who underwent CNB using 18-20G full-core Menghini needles, with a median macroscopic fragment dimension of 1 cm. Cohort B included patients who underwent CNB with 16-18G semiautomatic guillotine needles, with a median macroscopic fragment dimension of 1.5 cm. In cohort A, the rates of diagnostic and non-diagnostic (or non-sufficiently detailed) CNBs were 95 (73%) versus 35 (27%), respectively. In cohort B, these rates were 299 (86%) versus 49 (14%). Conclusion The type and size of the needle used for CNB, as well as the histologic variant of LD, emerged as factors influencing diagnostic yield and accuracy. Given the swiftness of CNB compared to surgical excision, optimizing this technique could streamline the diagnostic and therapeutic workflow for patients with suspected LD.
Preclinical development of anti-CD21 chimeric antigen receptor T cells to treat T cell acute lymphoblastic leukemia
Nicola Maciocia, Malika Hoekx, Ciaran Acuna, Brandon Wade, Amy Burley, Saumya Ramanayake, Francesco Nannini, Patrycja A. Wawrzyniecka, Thaneswari Karpanasamy, Maria Schuldt, Stephanie Ng, Mathieu Ferrari, Teresa Marafioti, Giuseppe Gritti, Shimobi Onuoha, David O’Connor, Lydia Lee, Marc Mansour, Asim Khwaja, Martin Pule, Paul Maciocia
Science Translational Medicine, 2025
Patients with relapsed/refractory (r/r) T cell acute lymphoblastic leukemia (T-ALL) have a dismal prognosis, highlighting the urgent need for effective therapies. Chimeric antigen receptor (CAR)–T cell approaches targeting pan–T cell antigens may be limited by T cell aplasia and fratricide, necessitating “rescue” allogeneic hematopoietic stem cell transplantation. In this study, we identify CD21, a pan–B cell marker, as a promising target for T-ALL immunotherapy. CD21 is expressed in 50% of T-ALL cases at diagnosis but in fewer than 10% of mature T cells. We observed that CAR-T cells targeting membrane-distal CD21 epitopes were ineffective, likely because of the bulky, glycosylated nature of the antigen. However, when we engineered CAR-T cells to target membrane-proximal CD21 epitopes using an antigen-binding fragment (Fab)–CAR design, we demonstrated robust activity against T-ALL cell lines, primary tumors, and patient-derived xenografts in both in vitro and in vivo models. The enhanced efficacy of this Fab-CAR design was driven by its high stability and reduced surface expression, addressing limitations of traditional CAR constructs. In addition, pharmacological inhibition of the phosphatidylinositol 3-kinase axis up-regulated CD21 expression in T-ALL, further enhancing the potency of anti-CD21 CAR-T cells in vitro and in a patient-derived xenograft in vivo model. This study establishes CD21 as a viable CAR-T target and highlights advances in CAR design for bulky antigens, as well as the potential for pharmacological strategies to augment target expression. Anti-CD21 CAR-T cells represent a promising therapeutic option for improving outcomes for patients with T-ALL.
Rapid immune reconstitution following the infusion of autologous, Blinatumomab Expanded T-cells (BET) in patients with B-cell indolent NHL or CLL
Giuseppe Gritti, Silvia Ferrari, Federico Lussana, Anna Maria Barbui, Francesco Landi, Monica Rondi, Alessandro Putelli, Francesco Ballardini, Giulia Quaresmini, Muriel Paganessi, Chiara Pavoni, Arianna Ghirardi, Elisa Gotti, Chiara Capelli, Josée Golay, Martino Introna, Alessandro Rambaldi
Blood Cancer Journal, 2024
First-line treatment with bendamustine-rituximab (BR) or fludarabine-cyclophosphamide-rituximab (FCR) is often used in indolent non-Hodgkin lymphoma (iNHL) and in selected cases of chronic lymphocytic leukemia (CLL) [ 1 , 2 ]. Despite the good results, combination chemotherapy using drugs with purine analog or purine analogs-like moieties (i.e. fludarabine or bendamustine) results in sustained B and T-cell depletion that can last years after treatment [ 3 , 4 ]. Indeed, it has been shown that efficient immunological recovery after chemotherapy requires multiple pathways that often evolve into a physiological age-dependent decline, resulting in a high frequency of long-term immune-deficient patients due to both dysfunctional and/or low absolute T-cell counts, especially in elderly patients [ 5 ].
Exposure to obinutuzumab does not affect outcomes of SARS-CoV-2 infection in vaccinated patients with newly diagnosed advanced-stage follicular lymphoma
A. Pinto, M. Caltagirone, M. Battista, G. C. Gazzoli, C. Patti, E. Pennese, S. De Lorenzo, V. Pavone, M. Merli, A. Chiarenza, A. G. Gorgone, F. Piazza, B. Puccini, A. Noto, L. Arcaini, R. De Filippi, P. L. Zinzani, A. J. M. Ferreri, M. Ladetto, S. Ferrari, G. Gritti
British Journal of Haematology, 2024
Valemetostat for patients with relapsed or refractory peripheral T-cell lymphoma (VALENTINE-PTCL01): a multicentre, open-label, single-arm, phase 2 study
Pier Luigi Zinzani, Koji Izutsu, Neha Mehta-Shah, Stefan K Barta, Kenji Ishitsuka, Raul Córdoba, Shigeru Kusumoto, Emmanuel Bachy, Kate Cwynarski, Giuseppe Gritti, Anca Prica, Eric Jacobsen, Tatyana Feldman, Yann Guillermin, Daisuke Ennishi, Dok Hyun Yoon, Eva Domingo Domenech, Jasmine Zain, Jie Wang, Jin Seok Kim, Marjolein van der Poel, Jin Jin, Sutan Wu, Yang Chen, Takaya Moriyama, Ai Inoue, Keiko Nakajima, Steven M Horwitz
Lancet Oncology, 2024
Predictive model for the risk of cytokine release syndrome with glofitamab treatment for diffuse large B-cell lymphoma
Giuseppe Gritti, Anton Belousov, James Relf, Mark Dixon, Maneesh Tandon, Krishna Komanduri
Blood Advances, 2024
Polatuzumab vedotin, venetoclax, and an anti-CD20 monoclonal antibody in relapsed/refractory B-cell non-Hodgkin lymphoma
Sam Yuen, Tycel J. Phillips, Rajat Bannerji, Paula Marlton, Giuseppe Gritti, John F. Seymour, Anna Johnston, Christopher Arthur, Anna Dodero, Sunil Sharma, Jamie Hirata, Lisa Musick, Christopher R. Flowers
American Journal of Hematology, 2024
Multidisciplinary and personalized approach to the management of mycosis fungoides with chlormethine gel: a collection of clinical experiences
Silvia Alberti Violetti, Marco Ardigò, Paolo Fava, Giuseppe Gritti, Erika Morsia, Francesco Onida, Marco Paulli, Alessandro Pileri, Pietro Quaglino, Serena Rupoli, Miriam Teoli, Pamela Vezzoli
Drugs in Context, 2024
Nivolumab combined with brentuximab vedotin for R/R primary mediastinal large B-cell lymphoma: a 3-year follow-up
Pier Luigi Zinzani, Armando Santoro, Giuseppe Gritti, Pauline Brice, Paul M. Barr, John Kuruvilla, David Cunningham, Justin Kline, Nathalie A. Johnson, Neha Mehta-Shah, Julie Lisano, Rachael Wen, Alev Akyol, Alison J. Moskowitz
Blood Advances, 2023
Treating relapsed/refractory mature T- and NK-cell neoplasms with tislelizumab: a multicenter open-label phase 2 study
Emmanuel Bachy, Kerry J. Savage, Huiqiang Huang, Yok-Lam Kwong, Giuseppe Gritti, Qingyuan Zhang, Anna Marina Liberati, Junning Cao, Haiyan Yang, Siguo Hao, Jianda Hu, Keshu Zhou, Mario Petrini, Filomena Russo, Huilai Zhang, Wei Sang, Jie Ji, Andrés José María Ferreri, Gandhi Laurent Damaj, Hui Liu, Wei Zhang, Xiaoyan Ke, Chiara Ghiggi, Sha Huang, Xiaotong Li, Hui Yao, Jason Paik, William Novotny, Wenxiao Zhou, Hongjie Zhu, Pier Luigi Zinzani
Blood Advances, 2023
Targeting MCL-1 and BCL-2 with polatuzumab vedotin and venetoclax overcomes treatment resistance in R/R non-Hodgkin lymphoma: Results from preclinical models and a Phase Ib study
Elisabeth A. Lasater, Dhara N. Amin, Rajat Bannerji, Raghuveer Singh Mali, Kathy Barrett, Ryan N. Rys, Jason Oeh, Eva Lin, Tim Sterne‐Weiler, Ellen Rei Ingalla, MaryAnn Go, Shang‐Fan Yu, Maxwell M. Krem, Chris Arthur, Uwe Hahn, Anna Johnston, Vinit Karur, Nadia Khan, Paula Marlton, Tycel Phillips, Giuseppe Gritti, John F. Seymour, Monica Tani, Sam Yuen, Scott Martin, Matthew T. Chang, Christopher M. Rose, Victoria C. Pham, Andrew G. Polson, YiMeng Chang, Claudia Wever, Nathalie A. Johnson, Yanwen Jiang, Jamie Hirata, Deepak Sampath, Lisa Musick, Christopher R. Flowers, Ingrid E. Wertz
American Journal of Hematology, 2023
Spleen tyrosine kinase/FMS-Like tyrosine kinase-3 inhibition in relapsed/refractory B-cell lymphoma, including diffuse large B-cell lymphoma: updated data with mivavotinib (TAK-659/ CB-659
Leo I. Gordon, Reem Karmali, Jason B. Kaplan, Rakesh Popat, Howard A. Burris, Silvia Ferrari, Sumit Madan, Manish R. Patel, Giuseppe Gritti, Dima El-Sharkawi, F. Ian Chau, John Radford, Jaime Pérez de Oteyza, Pier Luigi Zinzani, Swaminathan P. Iyer, William Townsend, Harry Miao, Igor Proscurshim, Shining Wang, Shilpi Katyayan, Ying Yuan, Jiaxi Zhu, Kate Stumpo, Yaping Shou, Cecilia Carpio, Francesc Bosch
Oncotarget, 2023
Autologous stem-cell transplantation as consolidation of first-line chemotherapy in patients with peripheral T-cell lymphoma: a multicenter GELTAMO/FIL study
Alejandro Martín García-Sancho, Monica Bellei, Miriam López-Parra, Giuseppe Gritti, María Cortés, Silvana Novelli, Carlos Panizo, Luigi Petrucci, Antonio Gutiérrez, Ivan Dlouhy, Mariana Bastos-Oreiro, Juan M. Sancho, María J. Ramírez, José M. Moraleda, Estrella Carrillo, Ana I. Jiménez-Ubieto, Isidro Jarque, Lorella Orsucci, Estefanía García-Torres, Carlos Montalbán, Anna Dodero, Reyes Arranz, Natalia De las Heras, María J. Pascual, Javier López-Jiménez, Michelle Spina, Alessandro Re, Sonia González De Villambrosia, Sabela Bobillo, Massimo Federico, Dolores Caballero
Haematologica, 2022
High inter-follicular spatial co-localization of CD8+FOXP3+ with CD4+CD8+ cells predicts favorable outcome in follicular lymphoma
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Anti-CCR9 chimeric antigen receptor T cells for T-cell acute lymphoblastic leukemia
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Blood, 2022
Human inhalable antibody fragments neutralizing SARS-CoV-2 variants for COVID-19 therapy
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Molecular Therapy, 2022
Genetic and phenotypic attributes of splenic marginal zone lymphoma
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Blood, 2022
Chimeric antigen receptor T cells for gamma–delta T cell malignancies
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Leukemia, 2022
Generation and validation of a PET radiomics model that predicts survival in diffuse large B cell lymphoma treated with R-CHOP14: A SAKK 38/07 trial post-hoc analysis
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Hematological Oncology, 2022
DeepMIF: Deep Learning Based Cell Profiling for Multispectral Immunofluorescence Images with Graphical User Interface
Yeman Brhane Hagos, Ayse U Akarca, Alan Ramsay, Riccardo L Rossi, Sabine Pomplun, Alessia Moioli, Andrea Gianatti, Christopher Mcnamara, Alessandro Rambaldi, Sergio A. Quezada, David Linch, Giuseppe Gritti, Teresa Marafioti, Yinyin Yuan
Lecture Notes in Computer Science Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics, 2022
Correction to: Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial (Journal of Translational Medicine, (2020), 18, 1, (405), 10.1186/s12967-020-02573-9)
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Gilberto, Luca Cantadori, Gabriele Tomasoni, Lina Rachele Tomasoni, Nicola Coppola, Stefano Spolveri, Costanza Pollastri, Lorenzo Fico, Tiziana Principi, Silvia Pierantozzi, Costantino Fontana, Giuseppe Lubrano, Laura Martinelli, Stefano Bravi, Paolo Navalesi, Eugenio Serra, Enrico Cogi, Andrea Manzi, Ermenegildo Furino, Nicola Dasseni, Claudio Gentilini, Elisa Benatti, Andrea Pignatti, Giuseppe Aiello, Mario Milia, Maria Grazia Covesnon, Annalisa Brianti, Claudio Francesco, Blangetti Ilaria, Fiammetta Pagnozzi, Sabrina Mietta, Alberto Rossi, Lorenzo Maroni, Vittorio Borroni, Claudio Bellintani, Camilla Sgarabotto, Giada Bizzotto, Lucio Bucci, Giovanni Spagnuolo, Moreno Agostini, Federico Carlo Caria, Filippo Testa, Raffaele De Palma, Giuseppe Murdaca, Gabriele Zanolini, Nadia Sala, Erminio Righini, Roberto Pontremoli, Gianmarco Aondio, Ferdinando Riccardi, Maria Giovanna De Cristoforo, Fausto De Michele, Angelo Storti, Roberto Perra, Silvia Deidda, Caviglia Enrica, Federico Valastro, 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Pietrangelo, Ombretta Para, Maria Serena Rutili, Roberto Russo, Maurizio Lanfranco, Elisa Scalabrino, Agostino Tafuri, Elisa Perfetti, Tosca Chiarello, Luca Cancanelli, Manuela Otero, Greta Pannella, Francesco Bellucci, Giovanna Ferrero, Carmen Vico, Maria Serafina Stillante, Giovanna D’Andrea, Filippo Amoroso, Antonio Arcidiacono, Anna Maria Bella, Agata Belsito, Ylenia Berté, Giulia Carubia, Maria Grazia Caruso, Orazio Casella, Francesco Chiereleson, Chiara Costa, Daniela De Franco, Giuseppe Germanà, Antonio Messina, Diana Musumeci, Concetta Noto, Marco Valenti, Carlo Sorrentino, Rosanna Panico, Giuseppe Schettino, Jolanda Piccoli, Antonio Pepe, Francesco De Rosa, Mario Ottaviano, Gerarda Marrazzo, Gianna Raponi, Stefania Diberardino, Simona Bausi, Alessandro Ferrari, Sara Francesca Marini, Elena Giubellino, Giorgio Innocenti, Gaspare Gugliemi, Daniela Maccari, Izabela Baciu, and
Journal of Translational Medicine, 2021
Correction: Siltuximab downregulates interleukin-8 and pentraxin 3 to improve ventilatory status and survival in severe COVID-19 (Leukemia, (2021), 35, 9, (2710-2714), 10.1038/s41375-021-01299-x)
Giuseppe Gritti, Federico Raimondi, Barbara Bottazzi, Diego Ripamonti, Ivano Riva, Francesco Landi, Leonardo Alborghetti, Marco Frigeni, Marianna Damiani, Caterina Micò, Stefano Fagiuoli, Ferdinando Luca Lorini, Lucia Gandini, Luca Novelli, Jonathan P. Morgan, Benjamin M. J. Owens, Karan J. K. Kanhai, Gordana Tonkovic Reljanovic, Marco Rizzi, Fabiano Di Marco, Alberto Mantovani, Alessandro Rambaldi
Leukemia, 2021
Siltuximab downregulates interleukin-8 and pentraxin 3 to improve ventilatory status and survival in severe COVID-19
Giuseppe Gritti, Federico Raimondi, Barbara Bottazzi, Diego Ripamonti, Ivano Riva, Francesco Landi, Leonardo Alborghetti, Marco Frigeni, Marianna Damiani, Caterina Micò, Stefano Fagiuoli, Ferdinando Luca Lorini, Lucia Gandini, Luca Novelli, Jonathan P. Morgan, Benjamin M. J. Owens, Karan J. K. Kanhai, Gordana Tonkovic Reljanovic, Marco Rizzi, Fabiano Di Marco, Alberto Mantovani, Alessandro Rambaldi
Leukemia, 2021
Extracorporeal cytokine hemadsorption in severe COVID-19 respiratory failure
Marianna Damiani, Lucia Gandini, Francesco Landi, Gianmaria Borleri, Fabrizio Fabretti, Giuseppe Gritti, Ivano Riva
Respiratory Medicine, 2021
Skip pattern approach toward the early access of innovative anticancer drugs
G. Apolone, A. Ardizzoni, A. Biondi, A. Bortolami, C. Cardone, C.M. Ciniselli, P. Conte, C. Crippa, F. de Braud, M. Duca, S. Gori, G. Gritti, A. Inno, R. Luksch, F. Lussana, M. Maio, G. Pasello, F. Perrone, A. Rambaldi, G. Rossi, D. Signorelli, G. Soverini, M. Valente, P. Verderio, G. Buzzetti
ESMO Open, 2021
Efficacy and safety results from CheckMate 140, a phase 2 study of nivolumab for relapsed/refractory follicular lymphoma
Philippe Armand, Ann Janssens, Giuseppe Gritti, John Radford, John Timmerman, Antonio Pinto, Santiago Mercadal Vilchez, Peter Johnson, David Cunningham, John P. Leonard, Scott J. Rodig, Patricia Martín-Regueira, Anne Sumbul, Selda Samakoglu, Hao Tang, Stephen M. Ansell
Blood, 2021
Immunotherapy of acute lymphoblastic leukemia and lymphoma with T cell–redirected bispecific antibodies
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Journal of Clinical Oncology, 2021
Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19
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Nature Immunology, 2021
Venetoclax-rituximab with or without bendamustine vs bendamustine-rituximab in relapsed/refractory follicular lymphoma
Pier Luigi Zinzani, Ian W Flinn, Sam L S Yuen, Max S Topp, Chiara Rusconi, et al.
Blood, 2020
Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial
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Gessica Infantino, Laura Camici, Francesca Covani Frigieri, Vittorio Pavoni, Lucia Migliori, Barbara Rossetti, Francesca Montagnini, Immacolata Mauro, Elvira Genovese, Antonio Capuozzo, Leonarda Vitiello, Emanuele Sirignano, Paolo Gnesin, Giuseppe Servillo, Alfredo Marinelli, Daniela Pasero, Sergio Babudieri, Giordano Madeddu, Andrea De Vito, Lorenzo Casadio, Melania Ranghitta, Rodolfo Passalacqua, Fioravanti Antonio, Ivan Gentile, Antonio Riccardo Buonomo, Riccardo Scotto, Emanuela Zappulo, Giuseppina Dell’Aquila, Angel Bianchetti, Fabio Guerini, Alfredo Vallone, Peppino Oppedisano, Luigi Pusterla, Omar Giglio, Grazia Russo, Enrico Sartori, Cristina Zanardini, Pietro Gatti, Valiani Vincenzo, Stefania Piconi, Chiara Molteni, Giuseppina Dognini, Franco Cosimo, Luigi Guarneri, Fabrizio Pulvirenti, Vincenzo Mondino, Gabriella Traballi, Enrico Iemoli, Antoenlla Grisolia, Riccardo Giorgi, Gabriella Nucera, Valentina Raffaelli, Pietro Marino, Enrica Negro, Lisa Serati, Tamanini Silvia, Carmelo Iacobello, Giuseppe Strano, Lucio Boglione, Alberto Catania, Paola Gipponi, Luca Di Cato, Anna Panaccione, Giovanni Vitale, Ilaria Alice Crippa, Matteo Giacomini, Adriano Basile, Bellone Andrea, Paolo Tundo, Stefano Buzzigoli, Gerardo Palmiero, Andrea Magnaca, Matteo Silva, Massimo Ricci, Stefano Crespi, Bernadetta Pasquino, Guglielmo Consales, Damiano Bragantini, Franco Mastroianni, Giulia Righetti, Antonio Scarafino, Michele Bitetto, Fabio Franzetti, Sandro Piga, Vito Delmonte, Sergio Carbonara, Ruggero Losappio, Christian Dejaco, Claudio Mastroianni, Valerio Del Bono, Fabio Gilioli, Daniela Barzan, Silvia De Struppi, Antonio Carlotto, Maria Licia Guadagnin, Massimo Girardis, Elisabetta Bertellini, Francesco Dentali, Giancarlo Foresta, Alberto Baratta, Rosangela Viviani, Antonio Maria Agrati, Giovanni Battista Perego, Arturo Montineri, Rosa Manuele, Salvatore Bonfante, Donatella Aquilini, Alessandra Prozzo, Donato Santopuoli, Zaira Di Rosa, Armando Alborghetti, Paolo Peci, Nikoloz Bakhtadze, Chiara Stefania Pandini, Giovanni Casati, Najat Ashofarir, Giampaolo Casella, Walter Spagnolli, Silvana Urru, Ivan Marchesoni, Giulia Caminiti, Elena Argilloni, Elisabetta Danieli, Gianluca Ghirardi, Chiara Maria Antonioli, Alessio Lipari, Paola Zavarise, Francesco Kokaly, Enrico Polati, Leonardo Gottin, Paolo Lucernoni, Fabio De Conti, Elisabetta Marcon, Emanuele Pontali, Elisabetta Blasi Vacca, Carolina Saffioti, Alessia Zunino, Erik Roman Pognuz, Giorgio Berlot, Martino Saltori, Andrea Tedesco, Carlo Agostini, Maria Antonietta Di Rosolini, Francesco Marino, Guido Bellinzona, Walter Grassi, Marco Di Carlo, Guglielmo Scimonello, Sandra Nonini, Michele Mondino, Lorenzo Filippo Mantovani, Elena Tenti, Concetta Maria Gabriella Tropea, Daniela Emanuela Di Stefano, Paolo Guelfi, Lorenzo Dagna, Gianfranco Morgana, Lidia Montemurro, Domenico Girelli, Ernesto Crisafulli, Alessio Maroccia, Alessandra Maria Cemuschi, Mara Bernasconi, Ugo Zummo, Valentina Barbato, Simona Bevilacqua, Gaetano Buonfanti, Giuliana Canzanella, Giovanni De Matteis, Manuela Florio, Marilena Martino, Maria Teresa Ribecco, Fiorella Romano, Alfonso Savio, Lucia Sparavigna, Marcello Curvietto, Michele Citarella, Valeria Nava, Paola Maggioni, Marta Magni, Chiara Iommelli, Antonella Bianco, Romina Corsini, Linda Valli, Maria Paola Ruggieri, Tiziana Melica, Alessandra Ferrari, Daniela Cicognini, Mariangela Delliponti, Andrea Zuccarini, Silvia Ciani, Davide Raffaeli, Luca Donati, Stefania Cannizzo, Stefania Lui, Luca Santini, Enrica Roncaglia, Pasquale Mighali, Frederik Eisendle, Giulia Cerino, Chiara Citterio, Camilla Di Nunzio, Annalisa Mancini, Silvia Lamonica, Silvia Resimini, Giovanni Sarteschi, Chiara Pavei, Nicholas Battistini, Ospedale Erika Gazzola, Marco Miceli, Silvia Pontiggia, Veronica Lonati, Giusy Giannandrea, Claudio Sortino, Serena Ravani, Cristiano Uggeri, Genny Jocollé, Cristina Baré, Irene Baroni, Daniele De Candia, Barbara Fiorini, Katiuscia Chierico, Francesca Romeo, Roberta Bottega, Laura Boccasile, Annamaria Corsaro, Claudia Spadoni, Silvia Chiari, Giovanna Ercolino, Vanessa Dell’uomo, Sabrina Viri, Milena Minato, Lisa Gazzola, Balan Dorina, Davide Gianelli, Sonia Maspero, Maddalena Farinazzo, Paola Zanini, Antonella Sangiovanni, Antonia Del Giudice, Maria Margherita Dragonetti, Susanna Bordignon, Andrea Marco Machiavelli, Giulia Chiodelli, Micaela Spatarella, Davide Zenoni, Flavio Niccolò Beretta, Giuseppina Santilli, Rita Badagliacca, Manuela Angileri, Luciana Giannelli, Annalisa Campomori, Patrizia Maimone, Andrea Fadda, Sonia Faoro, Alessia Pisterna, Bruno Cacopardo, Andrea Marino, Alessio Pampaloni, Benedetto Maurizio Celesia, Gilda Cinnella, Daniela Labella, Rosa Roberta Caporusso, Maria Danzi, Marta Fiscon, Marina Malena, Doris Fendt, Stefano Nardi, Paolo Stobbione, Maria Laura Savi, Andrea De Monte, Alberto Scala, Nicola Lucio Liberato, Sauro Luchi, Antonella Vincenti, Luca Cabrini, Giovanni Pinelli, Lucio Brugioni, Domenico Potenza, Fabio Giuliano Numis, Giovanni Porta, Maria D’amico, Bianca Iengo, Gioacchino Angarano, Annalisa Saracino, Livio Blasi, Pasquale De Negri, Stefano Angelici, Antonella Farina, Giuseppe Pio Martino, Giuseppina Bitti, Alberto Tedeschi, Simona De Ponti, Adriana Agostinone, Giustino Parruti, Augusta Consorte, Antonella Frattari, Amelia Filippelli, Pasquale Pagliano, Alfonso Masullo, Carmine Sellitto, Massimo Reta, Nicolò Rossi, Luigi Raumer, Silvia Andreassi, Paolo Brancaleoni, Antonina Carai, Anna Maria Salerno, Franco Marinangeli, Roberta Mariani, Antonello Ciccone, Carlo Meschini, Gianluca Santoboni, Claudio Angrisani, David Micarelli, Giovanna Tarquini, Vittorio Fregoni, Carlo Alberto Volta, Antonio Cherubini, Maria Simona Del Prete, Erika Ciarrochi, Francesca Tasca, Andrea Ballarin, Andrea Bianchin, Romeo Flocco, Vincenzo Cuzzone, Maurilio Carpinteri, Pietro Gallotti, Federica Torre, Pio Zannetti, Massimo Crapis, Sergio Venturini, Massimo Barattini, Gianluca Gori, Antonio Mastroianni, Giulio De Stefano, Michele Gilio, Giuseppe Rapisarda, Leonardo Gulisano, Maria Luisa Granata, Sebastiana Saglimbene, Maria Teresa Montalto, Ilaria Grasso, Silvana De Luca, Gaetano Magro, Florinda Messina, Bruno Scapino, Paolo Abrate, Chiara Francisco, Laura Pesce, Mauro Navarra, Michele Agosti, Silvia Pagani, Martina Piluso, Aristodemo Ricioppo, Silvia Tognella, Pierangelo Rovere, Marcello Vincenzi, Leonardo Ghirardi, Daniele Generali, Marco Ingrosso, Emilia Desiderio, Raffaele Molaro, Silvio Vitiello, Alessandro Mastroianni, Luca Lancione, Tonia Celeste Paone, Alessandro Meli, Stefano Mainardi, Valentina Rastellino, Antonia Ursillo, Paola di Grigoli, Elena Bovetto, Ivana Marina Stefanetto, Francesca Mazzola, Antonio Daniele, Claudia Bisio, Pietro Delnero, Giovanni Morando, Antonella Nava, Lemut Francesco, Fabio Fiammengo, Monica Regis, Dario Roccatello, Eugenio Sabato, Marco Maria Liccardi, Cristina Bretto, Lorenzo Lutri, Enzo Castenetto, Giuseppe Roberti, Maria Francesca Guidi, Francesco Bini, Maria Crisitna Zappa, Tiziana Trequattrini, Rosario Rivitti, Rossana Vigliarolo, Angela Succu, Marianna Lilli, Mattia Serao, Giuseppina Giogré, Annamaria Ruggieri, Kristoffer Flores, Giuseppe Vairo, Roberto Satira, Anna Lingua, Rosario Spina, Emanuele Nicastri, Gaetano Maffongelli, Filippo Barreca, Sabino Scollet, Federico Franchi, Camilla Fabbri, Pietro Minuz, Andrea Dalbeni, Paolo Zanatta, Domenico Gelormini, Anna Mandelli, Feliciano Galderisi, Elena Zoia, Maria Rita Marchi, Naile De Almeida Neves, Giorgio Carbone, Emilio Di Caterino, Anna Petrone, Carlo Andrea Usai, Francesco Bandiera, Roberto Monti, Alex Hofer, Giacomo Castiglione, Chiara Angeletti, Paolo Tarsia, Lorenzo Veronese, Paola Daniela Artoni, Dora Larussa, Roberto Fumagalli, Paolo Brioschi, Alessandro Cerutti, Paola Pasquino, Fiore Gilberto, Luca Cantadori, Gabriele Tomasoni, Lina Rachele Tomasoni, Nicola Coppola, Stefano Spolveri, Costanza Pollastri, Lorenzo Fico, Tiziana Principi, Silvia Pierantozzi, Costantino Fontana, Giuseppe Lubrano, Laura Martinelli, Stefano Bravi, Paolo Navalesi, Eugenio Serra, Enrico Cogi, Andrea Manzi, Ermenegildo Furino, Nicola Dasseni, Claudio Gentilini, Elisa Benatti, Andrea Pignatti, Giuseppe Aiello, Mario Milia, Maria Grazia Covesnon, Annalisa Brianti, Claudio Francesco, Blangetti Ilaria, Fiammetta Pagnozzi, Sabrina Mietta, Alberto Rossi, Lorenzo Maroni, Vittorio Borroni, Claudio Bellintani, Camilla Sgarabotto, Giada Bizzotto, Lucio Bucci, Giovanni Spagnuolo, Moreno Agostini, Federico Carlo Caria, Filippo Testa, Raffaele De Palma, Giuseppe Murdaca, Gabriele Zanolini, Nadia Sala, Erminio Righini, Roberto Pontremoli, Gianmarco Aondio, Ferdinando Riccardi, Maria Giovanna De Cristoforo, Fausto De Michele, Angelo Storti, Roberto Perra, Silvia Deidda, Caviglia Enrica, Federico Valastro, Matteo Giorgi Pierfranceschi, Fabio De Gennaro, Anna Laura Nardecchia, Mariateresa Castellini, Giovanni Buetto, Giovanbattista Ippoliti, Domenico Sicheri, Maria Grazia Bottoli, Blanca Martinez Lopez De Arroyabe, Alessandra Versaci, Casa Di Cura Villa Giada Pallotti, Marina Civita, Michele Grio, Nicola Liuzzi, Paola Molino, Mauro Pastorelli, Alberto Ricchiardi, Ferdinando Varbella, Angela Daniela Zeme, Cinzia Sighieri, Grazia Portale, Alessandro Olivetti, Carlo Pagnoni, Greta Moschini, Sabrina Boni, Alberto Guerra, Roberta Scudellari, Sabrina Vella, Sandro Inchiostro, Ornella Piazza, Salvatore Guarino, Giorgio Aldegheri, Giovanna Napoli, Alessandro Morettini, Eleonora Caldini, Lorenzo Menicacci, Filippo Pieralli, Monica Torrini, Loredana Poggesi, Enrico Maria Visetti, Carmelo Mangano, Stefano Visconti, Pasquale Maietta, Elisa Banfi, Stefania Cartella, Bruna Venturi, Antonia Nuceri, Elena Chiesa, Enrico Pacentra, Gianluigi Panzolato, Michella Giannotti, Cristina Bianchi, Antonello Pietrangelo, Ombretta Para, Maria Serena Rutili, Roberto Russo, Maurizio Lanfranco, Elisa Scalabrino, Agostino Tafuri, Elisa Perfetti, Tosca Chiarello, Luca Cancanelli, Manuela Otero, Greta Pannella, Francesco Bellucci, Giovanna Ferrero, Carmen Vico, Maria Serafina Stillante, Giovanna D’Andrea, Filippo Amoroso, Antonio Arcidiacono, Anna Maria Bella, Agata Belsito, Ylenia Berté, Giulia Carubia, Maria Grazia Caruso, Orazio Casella, Francesco Chiereleson, Chiara Costa, Daniela De Franco, Giuseppe Germanà, Antonio Messina, Diana Musumeci, Concetta Noto, Marco Valenti, Carlo Sorrentino, Rosanna Panico, Giuseppe Schettino, Jolanda Piccoli, Antonio Pepe, Francesco De Rosa, Mario Ottaviano, Gerarda Marrazzo, Gianna Raponi, Stefania Diberardino, Simona Bausi, Alessandro Ferrari, Sara Francesca Marini, Elena Giubellino, Giorgio Innocenti, Gaspare Gugliemi, Daniela Maccari, Izabela Baciu, and
Journal of Translational Medicine, 2020
Sleeping Beauty–engineered CAR T cells achieve antileukemic activity without severe toxicities
Chiara F. Magnani, Giuseppe Gaipa, Federico Lussana, Daniela Belotti, Giuseppe Gritti, Sara Napolitano, Giada Matera, Benedetta Cabiati, Chiara Buracchi, Gianmaria Borleri, Grazia Fazio, Silvia Zaninelli, Sarah Tettamanti, Stefania Cesana, Valentina Colombo, Michele Quaroni, Giovanni Cazzaniga, Attilio Rovelli, Ettore Biagi, Stefania Galimberti, Andrea Calabria, Fabrizio Benedicenti, Eugenio Montini, Silvia Ferrari, Martino Introna, Adriana Balduzzi, Maria Grazia Valsecchi, Giuseppe Dastoli, Alessandro Rambaldi, Andrea Biondi
Journal of Clinical Investigation, 2020
Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab
Alessandro Rambaldi, Giuseppe Gritti, Maria Caterina Micò, Marco Frigeni, Gianmaria Borleri, Anna Salvi, Francesco Landi, Chiara Pavoni, Aurelio Sonzogni, Andrea Gianatti, Francesca Binda, Stefano Fagiuoli, Fabiano Di Marco, Luca Lorini, Giuseppe Remuzzi, Steve Whitaker, Gregory Demopulos
Immunobiology, 2020
Phase I Study of TAK-659, an Investigational, Dual SYK/FLT3 Inhibitor, in Patients with B-Cell Lymphoma A C
Leo I. Gordon, Jason B. Kaplan, Rakesh Popat, Howard A. Burris, Silvia Ferrari, Sumit Madan, Manish R. Patel, Giuseppe Gritti, Dima El-Sharkawi, Ian Chau, John A. Radford, Jaime Pérez de Oteyza, Pier Luigi Zinzani, Swaminathan Iyer, William Townsend, Reem Karmali, Harry Miao, Igor Proscurshim, Shining Wang, Yujun Wu, Kate Stumpo, Yaping Shou, Cecilia Carpio, Francesc Bosch
Clinical Cancer Research, 2020
Erratum: SAKK38/07 study: Integration of baseline metabolic heterogeneity and metabolic tumor volume in DLBCL prognostic model (Blood Advances (2020) 4:6 (1082-1092) DOI: 10.1182/bloodadvances.2019001201)
Blood Advances, 2020
SAKK38/07 study: Integration of baseline metabolic heterogeneity and metabolic tumor volume in DLBCL prognostic model
Luca Ceriani, Giuseppe Gritti, Luciano Cascione, Maria Cristina Pirosa, Angela Polino, Teresa Ruberto, Anastasios Stathis, Andrea Bruno, Alden A. Moccia, Luca Giovanella, Stefanie Hayoz, Sämi Schär, Stefan Dirnhofer, Alessandro Rambaldi, Giovanni Martinelli, Christoph Mamot, Emanuele Zucca
Blood Advances, 2020
Copanlisib synergizes with conventional and targeted agents including venetoclax in B- And T-cell lymphoma models
Chiara Tarantelli, Martin Lange, Eugenio Gaudio, Luciano Cascione, Filippo Spriano, Ivo Kwee, Alberto J. Arribas, Andrea Rinaldi, Thibaud Jourdan, Melanie Berthold, Andrea Sturz, Carolyn Sperl, Francesco Margheriti, Lorenzo Scalise, Giuseppe Gritti, Davide Rossi, Anastasios Stathis, Ningshu Liu, Emanuele Zucca, Oliver Politz, Francesco Bertoni
Blood Advances, 2020
Outcome in patients with diffuse large B-cell lymphoma who relapse after autologous stem cell transplantation and receive active therapy. A retrospective analysis of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation (EBMT)
E. González-Barca, A. Boumendil, D. Blaise, M. Trněný, T. Masszi, H. Finel, M. G. Michieli, J. T. Bittenbring, G. Gritti, J. A. Snowden, M. Bishton, B. Bruno, S. González de Villambrosia, A. Janikova, X. Leleu, A. Anagnostopoulos, X. Poiré, M. Crysandt, Z. N. Özkurt, E. Vandenberghe, M. Itälä-Remes, J. Y. Cahn, E. Jantunen, W. Schroyens, J. Maertens, A. Esquirol, P. Dreger, S. Montoto, A. Sureda
Bone Marrow Transplantation, 2020
Durability of complete response after blinatumomab therapy for relapsed/refractory diffuse large B-cell lymphoma
Andreas Viardot, Georg Hess, Ralf C. Bargou, Nicholas J. Morley, Giuseppe Gritti, Maria-Elisabeth Goebeler, Karim Iskander, David Cohan, Alicia Zhang, Janet Franklin, Luke Coyle
Leukemia and Lymphoma, 2020
Nivolumab combined with brentuximab vedotin for relapsed/refractory primary mediastinal large B-cell lymphoma: Efficacy and safety from the phase II checkmate 436 study
Pier Luigi Zinzani, Armando Santoro, Giuseppe Gritti, Pauline Brice, Paul M. Barr, John Kuruvilla, David Cunningham, Justin Kline, Nathalie A. Johnson, Neha Mehta-Shah, Thomas Manley, Stephen Francis, Manish Sharma, Alison J. Moskowitz
Journal of Clinical Oncology, 2019
Correction: Evaluation of tenascin-C by tenatumomab in T-cell non-Hodgkin lymphomas identifies a new target for radioimmunotherapy [Oncotarget. 9 (2018) (9766-9775)] doi: 10.18632/oncotarget.23919
Giuseppe Gritt, Andrea Gianatt, Fiorella Petronzeii, Rita De Santis, Chiara Pavoni, Riccardo Lorenzo Rossi, Laura Cattaneo, Luigi Giusto Spagnoli, Silvia Ferrar, Andrea Ross, Anna Maria Barbu, Alessandro Rambald
Oncotarget, 2018
FarmaREL: An Italian pharmacovigilance project to monitor and evaluate adverse drug reactions in haematologic patients
Nicola S. Fracchiolla, Silvia Artuso, Agostino Cortelezzi, Anna M. Pelizzari, Paola Tozzi, Maurizio Bonfichi, Federica Bocchio, Livio Gargantini, Elisa De Rosa, Giuseppe D. Vighi, Lucia Prestini, Simona Sammassimo, Niccolò Frungillo, Maria C. Pasquini, Alessandra Ragazzi, Daniele Boghi, Alessia Pastore, Eraldo Lanzi, Giuseppe Gritti, Giulia Quaresmini, Simone Voltolini, Roberta Gaiardoni, Consuelo Corti, Maria C. Vilardo, Maria L. La Targia, Giacomo Berini, Massimo Magagnoli, Claudia Bacci, Dario Consonni, Alma L. Rivolta, Giuliana Muti
Hematological Oncology, 2018
Evaluation of tenascin-C by tenatumomab in T-cell non-Hodgkin lymphomas identifies a new target for radioimmunotherapy
Giuseppe Gritti, Andrea Gianatti, Fiorella Petronzelli, Rita De Santis, Chiara Pavoni, Riccardo Lorenzo Rossi, Laura Cattaneo, Luigi Giusto Spagnoli, Silvia Ferrari, Andrea Rossi, Anna Maria Barbui, Alessandro Rambaldi
Oncotarget, 2018
Italian real-life experience with brentuximab vedotin: Results of a large observational study of 40 cases of relapsed/refractory systemic anaplastic large cell lymphoma
Alessandro Broccoli, Cinzia Pellegrini, Alice Di Rocco, Benedetta Puccini, Caterina Patti, Guido Gini, Donato Mannina, Monica Tani, Chiara Rusconi, Alessandra Romano, Anna Vanazzi, Barbara Botto, Carmelo Carlo-Stella, Stefan Hohaus, Pellegrino Musto, Patrizio Mazza, Stefano Molica, Paolo Corradini, Angelo Fama, Francesco Gaudio, Michele Merli, Angela Gravetti, Giuseppe Gritti, Annalisa Arcari, Patrizia Tosi, Anna Marina Liberati, Antonello Pinto, Vincenzo Pavone, Filippo Gherlinzoni, Virginia Naso, Stefano Volpetti, Livio Trentin, Maria Cecilia Goldaniga, Maurizio Bonfichi, Amalia De Renzo, Corrado Schiavotto, Michele Spina, Sergio Storti, Angelo Michele Carella, Vittorio Stefoni, Lisa Argnani, Pier Luigi Zinzani
Haematologica, 2017
Is there a role for minimal residual disease monitoring in follicular lymphoma in the chemo-immunotherapy era?
Giuseppe Gritti, Chiara Pavoni, Alessandro Rambaldi
Mediterranean Journal of Hematology and Infectious Diseases, 2017
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies
Paul M Maciocia, Patrycja A Wawrzyniecka, Brian Philip, Ida Ricciardelli, Ayse U Akarca, Shimobi C Onuoha, Mateusz Legut, David K Cole, Andrew K Sewell, Giuseppe Gritti, Joan Somja, Miguel A Piris, Karl S Peggs, David C Linch, Teresa Marafioti, Martin A Pule
Nature Medicine, 2017
Italian real life experience with brentuximab vedotin: Results of a large observational study on 234 relapsed/refractory Hodgkin's lymphoma
Cinzia Pellegrini, Alessandro Broccoli, Alessandro Pulsoni, Luigi Rigacci, Caterina Patti, Guido Gini, Donato Mannina, Monica Tani, Chiara Rusconi, Alessandra Romano, Anna Vanazzi, Barbara Botto, Armando Santoro, Stefan Hoaus, Gian Matteo Rigolin, Pellegrino Musto, Patrizio Mazza, Stefano Molica, Paolo Corradini, Angelo Fama, Francesco Gaudio, Michele Merli, Fioravante Ronconi, Giuseppe Gritti, Daniele Vallisa, Patrizia Tosi, Anna Marina Liberati, Antonello Pinto, Vincenzo Pavone, Filippo Gherlinzoni, Maria Paola Bianchi, Stefano Volpetti, Livio Trentin, Maria Cecilia Goldaniga, Maurizio Bonfichi, Amalia De Renzo, Corrado Schiavotto, Michele Spina, Angelo Michele Carella, Vittorio Stefoni, Lisa Argnani, Pier Luigi Zinzani
Oncotarget, 2017
Randomized trial comparing R-CHOP versus high-dose sequential chemotherapy in high-risk patients with diffuse large B-cell lymphomas
Sergio Cortelazzo, Corrado Tarella, Alessandro Massimo Gianni, Marco Ladetto, Anna Maria Barbui, Andrea Rossi, Giuseppe Gritti, Paolo Corradini, Massimo Di Nicola, Caterina Patti, Antonino Mulé, Manuela Zanni, Valerio Zoli, Atto Billio, Andrea Piccin, Giovanni Negri, Claudia Castellino, Francesco Di Raimondo, Andrés J.M. Ferreri, Fabio Benedetti, Giorgio La Nasa, Guido Gini, Livio Trentin, Maurizio Frezzato, Leonardo Flenghi, Simona Falorio, Marco Chilosi, Riccardo Bruna, Valentina Tabanelli, Stefano Pileri, Arianna Masciulli, Federica Delaini, Cristina Boschini, Alessandro Rambaldi
Journal of Clinical Oncology, 2016
A data-driven network model of primary myelofibrosis: Transcriptional and post-transcriptional alterations in CD34+ cells
E Calura, S Pizzini, A Bisognin, A Coppe, G Sales, E Gaffo, T Fanelli, C Mannarelli, R Zini, R Norfo, V Pennucci, R Manfredini, C Romualdi, P Guglielmelli, A M Vannucchi, S Bortoluzzi, on behalf of the Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators
Blood Cancer Journal, 2016
Primary treatment response rather than front line stem cell transplantation is crucial for long term outcome of peripheral T-cell lymphomas
Giuseppe Gritti, Cristina Boschini, Andrea Rossi, Federica Delaini, Anna Grassi, Alessandra Algarotti, Caterina Micò, Rosangela Trezzi, Andrea Gianatti, Anna Maria Barbui, Alessandro Rambaldi
Plos One, 2015
Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: Implications for combination therapy
F. D. Roit, P. J. Engelberts, R. P. Taylor, E. C. W. Breij, G. Gritti, A. Rambaldi, M. Introna, P. W. H. I. Parren, F. J. Beurskens, J. Golay
Haematologica, 2015
Rate of primary refractory disease in B and T-Cell non-Hodgkin's Lymphoma: Correlation with long-term survival
Corrado Tarella, Angela Gueli, Federica Delaini, Andrea Rossi, Anna Maria Barbui, Giuseppe Gritti, Cristina Boschini, Daniele Caracciolo, Riccardo Bruna, Marco Ruella, Daniela Gottardi, Roberto Passera, Alessandro Rambaldi
Plos One, 2014
Bendamustine in combination with Ofatumumab in relapsed or refractory chronic lymphocytic leukemia: A GIMEMA Multicenter Phase II Trial
A Cortelezzi, M Sciumè, A M Liberati, D Vincenti, A Cuneo, G Reda, L Laurenti, F Zaja, R Marasca, A Chiarenza, G Gritti, L Orsucci, S Storti, E Angelucci, N Cascavilla, M Gobbi, F R Mauro, F Morabito, S Fabris, A Piciocchi, M Vignetti, A Neri, D Rossi, D Giannarelli, A Guarini, R Foà, on behalf of the GIMEMA Chronic Lymphoproliferative Disorders Working Party
Leukemia, 2014
The lymphocyte to monocyte ratio improves the IPI-risk definition of diffuse large B-cell lymphoma when rituximab is added to chemotherapy
Alessandro Rambaldi, Cristina Boschini, Giuseppe Gritti, Federica Delaini, Elena Oldani, Andrea Rossi, Anna Maria Barbui, Daniele Caracciolo, Marco Ladetto, Angela Gueli, Alberto De Crescenzo, Roberto Passera, Liliana Devizzi, Caterina Patti, Alessandro Massimo Gianni, Corrado Tarella
American Journal of Hematology, 2013
Low-dose alemtuzumab-associated immune thrombocytopenia in chronic lymphocytic leukemia
Gianluigi Reda, Francesco Maura, Giuseppe Gritti, Anna Gregorini, Francesca Binda, Francesca Guidotti, Alfonso Piciocchi, Carlo Visco, Francesco Rodeghiero, Agostino Cortelezzi
American Journal of Hematology, 2012
Successful management with intravenous immunoglobulins in alemtuzumab-induced acute inflammatory demyelinating neuropathy: Clinical report of three patients
Roberto Castelli, Giuseppe Gritti, Antonino Cannavò, Guido Moreo, Giancarlo Conti, Gianluigi Reda, Agostino Cortelezzi
Immunopharmacology and Immunotoxicology, 2012
Low dose alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia
Giuseppe Gritti, Gianluigi Reda, Francesco Maura, Alfonso Piciocchi, Luca Baldini, Stefano Molica, Antonino Neri, Agostino Cortelezzi
Leukemia and Lymphoma, 2012
An Italian retrospective study on the routine clinical use of low-dose alemtuzumab in relapsed/refractory chronic lymphocytic leukaemia patients
Agostino Cortelezzi, Giuseppe Gritti, Luca Laurenti, Antonio Cuneo, Stefania Ciolli, Nicola Di Renzo, Pellegrino Musto, Francesca R. Mauro, Nicola Cascavilla, Lorenzo Falchi, Francesco Zallio, Vincenzo Callea, Francesco Maura, Sara Martinelli, Alfonso Piciocchi, Gianluigi Reda, Robin Foà, on behalf of the GIMEMA Chronic Lymphoproliferative Disorders Working Party
British Journal of Haematology, 2012
Circulating and progenitor endothelial cells are abnormal in patients with different types of von Willebrand disease and correlate with markers of angiogenesis
Giuseppe Gritti, Agostino Cortelezzi, Paolo Bucciarelli, Francesca Rezzonico, Silvia Lonati, Silvia La Marca, Ilaria Silvestris, Augusto B. Federici
American Journal of Hematology, 2011
Pulmonary arterial hypertension in primary myelofibrosis is common and associated with an altered angiogenic status [7]
A Cortelezzi, G Gritti, N Del Papa, M C Pasquini, R Calori, U Gianelli, M Cortiana, G Parati, F Onida, F Sozzi, C Vener, P Bianchi, G L Deliliers
Leukemia, 2008

Giuseppe Gritti

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