Antidiabetic efficacy of sea fish oil in ameliorating hyper-glycaemia by enhancing FFAR1, GLP-1 and inhibiting DPP-4 signalling in the pancreatic tissues of high lipid diet and streptozotocin-induced type 2 diabetic rats Shrabanti Pyne, Meghamala Mandal, Sanjay Das, Supriya Bhowmick, Koushik Das, J. Sreenavasa Rao, Jayasree Laha Acta Biologica Szegediensis, 2023 Eicosapentaenoic acid and docosahexaenoic acid are n-3 fatty acids that are highly available in sea-fishes. Many studies have revealed that n-3 fatty acids play antidiabetic activity. In this study antidiabetic activity of the three sea fishes oils, ‘volavetki’ (Panna microdon, Bleeker 1849), ‘ruli’ (Coilia dussumieri, Valenciennes 1848), and ‘tapra’ (Opisthopterus tardoore, Cuvier 1829), as well as three fresh-water fishes oils, ‘bata’ (Labeo bata, Hamilton 1822), ‘folui’ (Opisthopterus tardoore, Cuvier 1829), and ‘mourala’ (Amblypharyngodon mola, Hamilton 1822) evaluated high lipid diet (HLD) and STZ-induced type 2 diabetes mellitus (T2DM) rats. The GC-MS analysis revealed high n-3 fatty acid content in volavetki oil. Supplementation of sea-fish oils and antidiabetic effect was monitored by fasting plasma blood glucose and HbA1c. Also, insulin, c-peptide, glucagon-like peptide-1, dipeptidyl peptidase-4, free fatty acid receptor 1, glucokinase, glucose-6 phosphatase, superoxide dismutase, glutathione peroxidase, catalase, malondialdehyde, plasma total cholesterol, low density lipoprotein, triglycerides, high density lipoprotein, c-reactive protein, total protein, alkaline phosphatase, and histopathology of pancreatic tissues were evaluated. Out of six fish oils, oral supplementation with volavetki oil resulted in significant reduction of plasma blood glucose, HbA1c of T2DM rat. All other parameters in T2DM rats were returned to near normally by treatment of volavetki oil. These findings strongly indicate that volavetki oil possess antidiabetic activity.
Anti-cancer potentiality of linoelaidic acid isolated from marine Tapra fish oil (Ophisthopterus tardoore) via ROS generation and caspase activation on MCF-7 cell line Ananya Dutta, Titli Panchali, Amina Khatun, Sreenivasa Rao Jarapala, Koushik Das, Kuntal Ghosh, Sudipta Chakrabarti, Shrabani Pradhan Scientific Reports, 2023 The implication of inflammation in the pathophysiology of several types of cancers has been under intense investigation. Conjugated fatty acids can modulate inflammation and present anticancer effects, promoting cancer cell death. In this paper, we evaluated the efficacy of new conjugated fatty acids isolated from marine Opisthopterus tardoore (Tapra fish) in human breast cancer cell lines MCF-7. Linoelaidic acid, a marine fish (O. tardoore) derived unsaturated fatty acids, showed effective anticancer activity against MCF-7. Cell viability (MTT) assay revealed a dose-dependent decline in cancer cell viability. It was noteworthy that 5 µM linoelaidic acid decreased the MCF-7 cell viability by 81.82%. Besides that, linoelaidic acid significantly (P< 0.05) increased the level of tumor necrosis factor-α (TNF-α) and interleukin-1 receptor antagonist (IL-1ra) studied by ELISA. Not only that, linoelaidic acid significantly decreased the reduced glutathione level and increased the oxidized glutathione level in MCF-7 cells indicating the oxidative stress inside the cell. Two different cell staining methods with acridine orange-ethidium bromide and DAPI confirmed that the linoelaidic acid rendered their detrimental effect on cancer cells. To decipher the mode of apoptosis Western blotting was performed in which the expression pattern of several proteins (p53, IL-10, and IL-1ra) established the apoptosis in the studied cell lines after linoelaidic acid exposure. Hence it may be conferred that linoelaidic acid has prompt anticancer activity. Therefore this drug can be used further for the treatment of cancer.
Anti-hyperlipidemic effect of oils from Sesamum indicum L. and Vicia faba L. on male Wistar rats Holima Khatun, Koushik Das, Dilip Kumar Nandi, Jayasree Laha, J. Sreenivasa Rao, Atiskumar Chattopadhyay Future Foods, 2021 This work evaluates the physicochemical properties and fatty acids profile of Sesamum indicum (SSiO) and Vicia faba (SVfO) seed oils, and studies the anti-hyperlipidemic activity of the composite oil (CO) of the seed oils in high lipid diet (HLD) induced male Wistar rats. To investigate the anti-hyperlipidemic activity of the CO, the rats were randomly assigned into six groups: group-I (control), group-II (HLD), group-III (HLD+CO-100 mg/kg), group-IV (HLD+CO-200 mg/kg), group-V (HLD+CO-400 mg/kg), and group-VI (HLD+atorvastatin-10 mg/kg). We found that the SSiO contained highest proportion of total polyunsaturated fatty acid (42.18%) and lowest proportion of total saturated fatty acid (16.21%), while the SVfO reflected highest total monounsaturated fatty acid (49.48%). In addition, the SSiO contained a high amount of oleic (41.30%) and linoleic acid (41.92%), whereas the SVfO contained a high amount of eicosenoic acid (44.26%). The administration of all the CO doses demonstrated a significant decrease in triglyceride, total cholesterol, low-density lipoprotein cholesterol, apolipoprotein-B, and malondialdehyde, and a significant increase in high-density lipoprotein cholesterol, apolipoprotein-A1, superoxide dismutase, and catalase levels. The CO was also effective in histopathological changes in adipose tissue. The promising findings indicate that the CO has potential utility as a natural supplement and functional food to prevent hyperlipidemia.
Reduction of oxidative stress and apoptosis in hyperlipidemic rats by composite oil (CO) of Sesamum indicum L. And Vicia faba L. Holima Khatun, Mousumi Mitra, Koushik Das, Atiskumar Chattopadhyay, Dilip Kumar Nandi Mediterranean Journal of Nutrition and Metabolism, 2021 BACKGROUND: Hyperlipidemia associated with cardiovascular diseases (CVDs) is a global health issue that can be alleviated by functional foods. OBJECTIVES: The present study aimed to investigate the effect of composite oil (CO) of sesame seed oil (SSiO) and Vicia faba seed oil (SVfO) on inflammatory factors, ROS generation level, and cell apoptosis level on high lipid diet (HLD) induced hyperlipidemic rat model. METHODS: Hyperlipidemic rat model was developed by feeding HLD to the experimental rats for eight weeks. Male albino rats weighing around 200–210 g were randomly divided into three equal groups: group I: control, received a normal diet; group II: received HLD for eight weeks, and group III: received the HLD with CO orally. After 60 days of treatment, the levels of C-reactive protein (CRP), interleukin (IL)-10; tumor necrosis factor (TNF)-α, IL-18, reactive oxygen species (ROS), and cell apoptosis were serially assessed. RESULTS: After eight weeks of CO treatment, TNF- α, IL-18, CRP, and oxidative ROS generation significantly decreased in CO treated group (group III) compared to group II. On the other hand, IL-10 levels significantly increased in CO treated group compared to group II animals. It was also observed that the percentage of the late apoptotic cell reduced considerably in the CO treated group (group III) compared to HLD-fed animals (group II). CONCLUSION: The results indicate that the CO could prevent CVDs via suppressing oxidative stress, and ameliorating inflammation and apoptosis in hyperlipidemic rats.
Supplementation of seed dust of vicia faba and sesame ameliorates high lipid diet-induced dyslipidemia in rats HOLIMA KHATUN, KOUSHIK DAS, DILIP KUMAR NANDI, ATISKUMAR CHATTOPADHYAY Current Research in Nutrition and Food Science, 2019 Dyslipidaemia is a life style disorder characterized by increased levels of total cholesterol, LDL cholesterol and triglycerides and also decreased HDL cholesterol levels which is turned into cardiovascular disease, a first leading cause of death in Worldwide. Lifestyle changes mainly healthy diet should be introduced to reduce the cardiovascular risk. Recent research on functional foods consumption for lipid-lowering effects has been well established. Seeds of Vicia faba (SVf) and sesame seeds (SSi) is one of the most popular foods due to high content of dietary fiber, proteins, vitamins, minerals, phytosterol, omega 3 fatty acids and other functional compounds. The study aimed to establish SVf and SSi as a powerful functional food for prevention and management of dyslipidemia. We formulated a normal diet (ND) and high lipid diet (HLD) for rats. HLD was formulated by increasing the 10.48%energy, 60.07% lipid, 100% cholesterol and 50% sucrose than ND. Rats were randomly divided into five groups fed ND, HLD, HLD+10%SVf dust,HLD+10%SSi dust and HLD + 5% SVf + 5% SSi of total food for 60 days. After 60 days of treatment, it was observed that there was a significant (p < 0.05) increase in plasma triglyceride, total cholesterol, LDL-C, malondialdehyde (MDA) and IL-18 levels but a significant (p < 0.05) decrease in HDL-C, superoxide dismutase (SOD) & catalase activity in HLD in compared with ND and other treated groups. HLD induced dyslipidemia while SVf and SSi produced antidyslipidemic activity decreasing plasma triglyceride, total cholesterol, LDL-C, MDA, IL-18 level and increasing HDL-C, SOD, and catalase. SVf and SSi combined feeding was potential synergistic effect and results suggest that this functional food consumption can prevent and management of dyslipidemia.
Consortia of bioactives in supercritical carbon dioxide extracts of mustard and small cardamom seeds lower serum cholesterol levels in rats: new leads for hypocholesterolaemic supplements from spices Soumi Chakraborty, Kaninika Paul, Priyanka Mallick, Shrabani Pradhan, Koushik Das, Saikat Chakrabarti, Dilip Kumar Nandi, Paramita Bhattacharjee Journal of Nutritional Science, 2019 Melatonin-rich and 1,8-cineole-rich extracts have been successfully obtained from yellow mustard (YM) and small cardamom (SC) seeds, respectively, employing green technology of supercritical CO2(SC-CO2) extraction. Chemical profiling confirmed the presence of melatonin and 1,8-cineole and co-extractants in the respective extracts. Electron paramagnetic resonance spectroscopy attested strong antioxidant activities of the extracts foregoing pan-assay interference compounds involved in spectroscopic analysis. These extracts also exhibited synergistic efficacies greater than unity confirming antioxidant synergy among the co-extracted bioactives therein. To ascertain hypocholesterolaemic efficacies, these extracts were co-administered orally with Triton X (at the pre-optimised dose of 175 mg/kg body weight (BW)) to Wistar albino rats at doses of 550, 175 and 55 mg/kg BW. Serum total cholesterol levels in the rats were monitored on days 3, 7, 15 and 21. On day 21, total cholesterol level reduced appreciably by 49·44 % in rats treated with YM seed extract and by 48·95 % in rats treated with SC seed extract, comparable with atorvastatin-administered rats (51·09 %). Either extract demonstrated inhibitory effects on hepatic 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase activity. A molecular docking exercise identified specific compounds in the extracts which possessed binding affinities comparable with therapeutically used HMG-CoA reductase inhibitors.In silicoandin vivostudies concertedly concluded that the consortium of bioactive components in the extracts cannot be considered as invalid metabolic panaceas and therefore these ‘green’ extracts could be safely subjected to clinical studies as preventive biotherapeutics for hypercholesterolaemia. These extracts could be consumedper seas hypocholesterolaemic supplements or could be ingredients of new spice-based therapeutic foods.
Hypoxia: A cause of acute renal failure and alteration of gastrointestinal microbial ecology DilipKumar Nandi, Animesh Samanta, Arpita Patra, Shreya Mandal, Suchismita Roy, Koushik Das, Sanjay Kar Saudi Journal of Kidney Diseases and Transplantation an Official Publication of the Saudi Center for Organ Transplantation Saudi Arabia, 2018 Oxygen is very important to the existence of life. Oxygen deficiency, defined as hypoxia, elicits adaptive responses in cells and tissues. Lower oxygen concentration can cause the alteration of renal function, affects the maintenance of a balance of the body fluids, electrolytes, pH, and blood pressure homeostasis. Impaired fluid regulation could, in addition, contribute to the precipitation of pulmonary edema and exacerbate hypoxemia which may accelerate the progression of chronic kidney disease. In this context, the present study attempted to evaluate the association of renal injury and oxidative stress at different atmospheric pressures (1829, 3657, and 5486 m). Limited fecal analysis of experimental animals was also done to evaluate the impact of hypobaric hypoxia on the composition of dominant gastrointestinal microbiota. The study was performed on 24 male Wister strain rats and divided into four groups (C, HA-I, HA-II, and HA-III), and exposure was carried out for seven days period. In hypoxic exposure rats, plasma urea, creatinine, electrolytes and malonaldehyde level elevated and catalase and superoxide dismutase level diminished significantly compared to the controls. Increase in blood uremia profile, toxicity markers, and lipid peroxidation marker enzymes indicated that hypoxia causes renal failure. Histological structures of the kidney of group HA-II and HA-III animals showed severe disorganization of glomerulus and dilation of renal tubules. These results indicate nephrotoxicity or acute renal failure can occur at hypobaric hypoxia and it also affected the gut microbial population. This alteration was observed significantly above 3000 m.
Physiological indications and gut-microbial community in army personnel in high- altitude and base-line environments: A comparative study Jordan Journal of Biological Sciences, 2018
Nephroprotective efficacy of Asparagus racemosus root extract on acetaminophen-induced renal injury in rats Suchismita Roy, Shrabani Pradhan, Shreya Mandal, Koushik Das, Dilip Kumar Nandi Acta Biologica Szegediensis, 2018 Acetaminophen-induced renal necrosis and insufficiency occurs in patients with acetaminophen overdose. Renal failure is rapidly assuming epidemic proportions globally. In absence of reliable and effective nephroprotective drugs, strategies towards exploring alternative therapies for treatment of kidney diseases are essential. Asparagus racemosus is a medicinal plant used for treatment of various ailments. This research was undertaken to investigate the protective effect of ethanol fraction of A. racemosus roots extract in acetaminophen-induced uraemia and renal failure in rats. Rats were co-administered with acetaminophen injection and oral administration of A. racemosus roots extract in an attempt of protection against renal failure. Uremic biomarkers significantly decreased, and elevated levels of antioxidant enzymes were found, in the animals treated with ethanol fraction of A. racemosus when compared with acetaminophen treated uremic animals. Also, histology of kidneys showed control like structure in animals treated with this extract but severe damage in the uremic animals. HPLC analysis of the ethanol fraction of A. racemosus roots extract revealed eight compounds out of which one had a retention time near to the quercetin standard. It may be concluded that this extract of A. racemosus has therapeutically useful nephroprotective potential.
Effect of phytosterol extract from sesame seed on experimentally induced hyperlipidemic rats: Dose dependent study International Journal of Pharma and Bio Sciences, 2016
Alpha-lipoic acid a cholesterol reducer for targeting acetaminophen induced uremic male albino rat models International Journal of Pharmaceutical Sciences Review and Research, 2014
Phytochemical analysis, Antimicrobial activity and assessment of potential compounds by thin layer chromatography of ethanol fraction of asparagus racemosus roots International Journal of Pharmacy and Pharmaceutical Sciences, 2014
Protective effect of aqueous extract of terminalia arjuna against dehydrating induced oxidative stress and uremia in male rat Iranian Journal of Pharmaceutical Research, 2010
Effect of extract of Withania Somnifera on dehydration-induced oxidative stress-related uremia in male rats. Saudi Journal of Kidney Diseases and Transplantation an Official Publication of the Saudi Center for Organ Transplantation Saudi Arabia, 2010
New experimental design: Dehydration induced uremia and oxidative stress on male albino rats, innovative approach to researchers for further study on kidney disease Pharmacologyonline, 2009
RECENT SCHOLAR PUBLICATIONS
A Comprehensive Review on DPP-4 Inhibitory Small Bioactive Peptides in Type-2 Diabetes Mellitus Management S Panda, S Bhowmick, M Pal, S Das, S Pyne, A Banerjee, K Das Food Nutrition, 100062 , 2026 2026
Modelling type 2 diabetes in rats via high-lipid diet and streptozotocin-induced insulin resistance and β-cell dysfunction assessed by C-peptide K Das 2026
Antidiabetic potential of volavetki sea fish protein hydrolysates in high lipid diet and streptozotocin-induced diabetic rats S Bhowmick, S Panda, M Pal, S Das, M Mandal, S Pyne, D Giri, K Das The Journal of Basic and Applied Zoology 87 (1), 7 , 2026 2026
Antidiabetic potential of sea fish mass by inhibiting di-peptidyl peptidase-IV and augmenting glucagon-like peptide-1 on high lipid diet and streptozotocin induced diabetic rats S Das, S Pyne, MK Paira, D Giri, B Das, S Bhowmik, S Pradhan, K Das Pharmacological Research-Natural Products 4, 100082 , 2024 2024 Citations: 4
Antidiabetic efficacy of sea fish oil in ameliorating hyperglycaemia by enhancing FFAR1, GLP-1 and inhibiting DPP-4 signalling in the pancreatic tissues of high lipid diet and … JL Shrabanti Pyne, Meghamala Mandal, Sanjay Das, Supriya Bhowmick, Koushik ... Acta Biologica Szegediensis 67 (1) , 2023 2023 Citations: 4
TO STUDY THE ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF OIL FROM LEAVES OF CAMELLIA SINENSIS L. IN EXPERIMENTAL ANIMAL MODELS KDJL Meghamala Mandal, Shrabanti Pyne , Supriya Bhowmik , Deblina Giri International Journal of Pharmaceutical Sciences and Research 14 (1), 1000-1017 , 2023 2023 Citations: 1
Protective Effect of Arjunakwatha and Arjunasheeta in Paracetamol-induced Kidney Injury in Rat Model KD Supriya Bhowmick , Deblina Giri , Meghamala Mandal , Shrabanti Pyne ... Int. J. Pharm. Investigation 13 (1), 53-61 , 2022 2022 Citations: 5
Anti-hyperlipidemic effect of oils from Sesamum indicum L. and Vicia faba L. on male Wistar rats H Khatun, K Das, DK Nandi, J Laha, JS Rao, A Chattopadhyay Future Foods 4, 100060 , 2021 2021 Citations: 7
Reduction of oxidative stress and apoptosis in hyperlipidemic rats by composite oil (CO) of Sesamum indicum L. and Vicia faba L. H Khatun, M Mitra, K Das, A Chattopadhyay, DK Nandi Mediterranean Journal of Nutrition and Metabolism 14 (1), 79-89 , 2021 2021 Citations: 3
Sea fish consumption is associated with lower risk of diabetes mellitus: A cross-sectional study S Pyne, S Bhowmik, P Pal, J Bhattacharya, S Giri, JK Laha, K Das Int J Nutri Sci 6 (4), 1060 , 2021 2021 Citations: 4
Consortia of bioactives in supercritical carbon dioxide extracts of mustard and small cardamom seeds lower serum cholesterol levels in rats: new leads for hypocholesterolaemic … S Chakraborty, K Paul, P Mallick, S Pradhan, K Das, S Chakrabarti, ... Journal of nutritional science 8, e32 , 2019 2019 Citations: 26
Supplementation of seed dust of Vicia faba and sesame ameliorates high lipid diet-induced dyslipidemia in rats K Das Current Research in Nutrition and Food Science Journal , 2019 2019 Citations: 10
Analysis of fatty acids from oil of green tea (Camellia sinensis L.) by gas chromatography coupled with flame ionization detector and its anticancer and antibacterial activity … M Mandal, K Das, DK Nandi, B Das, RJ Sreenivas Int J Pharm Pharmaceut Sci 11 (3), 104-111 , 2019 2019 Citations: 4
Establishment of novel urinary kidney disease new biomarkers and therapeutic effect of methanol fraction of Terminalia arjuna on acetaminophen induced kidney disease in rats D Giri, K Das, DK Nandi Asian J Pharm Clin Res 12 (3), 117-124 , 2019 2019 Citations: 8
Nephroprotective efficacy of Asparagus racemosus root extract on acetaminophen-induced renal injury in rats S Roy, S Pradhan, S Mandal, K Das, DK Nandi Acta Biologica Szegediensis 62 (1), 17-23 , 2018 2018 Citations: 9
Hypoxia: A cause of acute renal failure and alteration of gastrointestinal microbial ecology A Samanta, A Patra, S Mandal, S Roy, K Das, S Kar, DK Nandi Saudi Journal of Kidney Diseases and Transplantation 29 (4), 879-888 , 2018 2018 Citations: 19
Physiological indications and gut-microbial community in army personnel in high-altitude and base-line environments: A comparative study A Samanta, A Patra, A Mandal, S Roy, S Mandal, K Das, B Sinha, S Kar, ... Jordan Journal of Biological Sciences (JJBS) 11 (2), 2141 , 2018 2018 Citations: 6
Nephro-protective activity of isolated methanol fractions phyto-compound from bark of Terminalia arjuna S Mandal, A Patra, S Pradhan, S Roy, A Samanta, K Das, ... Int J Pharm Pharm Sci 9, 175-80 , 2017 2017 Citations: 5
To investigate which solvent extract (aqueous, methanol, acetone and hexane) of Apple banana is more potent content of phytocompound S Maity, K Das, N Mandal International Journal of Physiology, Nutrition and Physical Education 1 (1 … , 2016 2016 Citations: 3
Effect of phytosterol extract from sesame seed on experimentally Induced hyperlipidemic rats: dose dependent study S Mallick, M Mandal, S Roy, S Pradhan, S Mandal, RK Maiti, DK Nandi, ... Int J Pharma Bio Sci 7, 370-377 , 2016 2016 Citations: 18
MOST CITED SCHOLAR PUBLICATIONS
Analysis of phytochemical profile of Terminalia arjuna bark extract with antioxidative and antimicrobial properties S Mandal, A Patra, A Samanta, S Roy, A Mandal, TD Mahapatra, ... Asian Pacific journal of tropical biomedicine 3 (12), 960-966 , 2013 2013 Citations: 264
Acetaminophen induced kidney failure in rats: A dose response study S Roy, S Pradhan, K Das, A Mandal, S Mandal, A Patra, A Samanta, ... Journal of Biological Sciences 15 (4), 187 , 2015 2015 Citations: 54
Protective effect of aqueous extract of Terminalia arjuna against dehydrating induced oxidative stress and uremia in male rat K Das, PP Chakraborty, D Ghosh, DK Nandi Iranian Journal of Pharmaceutical Research: IJPR 9 (2), 153 , 2010 2010 Citations: 51
Attenuation of uremia by orally feeding alpha-lipoic acid on acetaminophen induced uremic rats S Pradhan, S Mandal, S Roy, A Mandal, K Das, DK Nandi Saudi Pharmaceutical Journal 21 (2), 187-192 , 2013 2013 Citations: 41
Effect of extract of Withania Somnifera on dehydration-induced oxidative stress-related uremia in male rats K Das, TT Samanta, P Samanta, DK Nandi Saudi Journal of Kidney Diseases and Transplantation 21 (1), 75-80 , 2010 2010 Citations: 34
In vivo assessment of bacteriotherapy on acetaminophen-induced uremic rats A Mandal, K Das, S Roy, KC Mondal, DK Nandi Journal of Nephrology 26 (1), 228-236 , 2013 2013 Citations: 33
Protective effect of composite extract of Withania somnifera, Ocimum sanctum and Zingiber officinale on swimming-induced reproductive Endocrine dysfunctions in male rat DS Misra, R Maiti, S Bera, K Das, D Ghosh IRANIAN JOURNAL OF PHARMACOLOGY AND THERAPEUTICS (IJPT) 4 (2), 110-117 , 2005 2005 Citations: 27
Consortia of bioactives in supercritical carbon dioxide extracts of mustard and small cardamom seeds lower serum cholesterol levels in rats: new leads for hypocholesterolaemic … S Chakraborty, K Paul, P Mallick, S Pradhan, K Das, S Chakrabarti, ... Journal of nutritional science 8, e32 , 2019 2019 Citations: 26
Therapeutic potential of different commercially available synbiotic on acetaminophen-induced uremic rats A Mandal, A Patra, S Mandal, S Roy, S Das Mahapatra, T Das Mahapatra, ... Clinical and Experimental Nephrology 19 (2), 168-177 , 2015 2015 Citations: 22
Hypoxia: A cause of acute renal failure and alteration of gastrointestinal microbial ecology A Samanta, A Patra, S Mandal, S Roy, K Das, S Kar, DK Nandi Saudi Journal of Kidney Diseases and Transplantation 29 (4), 879-888 , 2018 2018 Citations: 19
Effect of phytosterol extract from sesame seed on experimentally Induced hyperlipidemic rats: dose dependent study S Mallick, M Mandal, S Roy, S Pradhan, S Mandal, RK Maiti, DK Nandi, ... Int J Pharma Bio Sci 7, 370-377 , 2016 2016 Citations: 18
Phytochemical analysis, antimicrobial activity and assessment of potential compounds by thin layer chromatography of ethanol fraction of Asparagus racemosus roots S Roy, S Pradhan, S Mandal, K Das, A Patra, A Samanta, B Sinha, S Kar, ... Int J Pharm Pharm Sci 6, 367-370 , 2014 2014 Citations: 14
Asparagus racemosus roots ameliorates acetaminophen induced hepatotoxicity in rats: an experimental, biochemical and histological study S Roy, K Das, S Mandal, S Pradhan, A Patra, A Samanta, A Mandal, S Kar, ... Int J Recent Sci Res 5 (6), 1192-7 , 2014 2014 Citations: 13
Supplementation of seed dust of Vicia faba and sesame ameliorates high lipid diet-induced dyslipidemia in rats K Das Current Research in Nutrition and Food Science Journal , 2019 2019 Citations: 10
Crude root extract of Asparagus racemosus ameliorates acetaminophen induced uremic rats S Roy, K Das, S Mandal, S Pradhan, A Patra, DK Nandi Int J Pharm Sci Res 4, 3004-12 , 2013 2013 Citations: 10
Nephroprotective efficacy of Asparagus racemosus root extract on acetaminophen-induced renal injury in rats S Roy, S Pradhan, S Mandal, K Das, DK Nandi Acta Biologica Szegediensis 62 (1), 17-23 , 2018 2018 Citations: 9
Establishment of novel urinary kidney disease new biomarkers and therapeutic effect of methanol fraction of Terminalia arjuna on acetaminophen induced kidney disease in rats D Giri, K Das, DK Nandi Asian J Pharm Clin Res 12 (3), 117-124 , 2019 2019 Citations: 8
Therapeutic potential of Lactobacillus ingluviei ADK10, a newly established probiotic organism against acetaminophen induced uremic rats A Mandal, T Paul, S Roy, S Mandal, S Pradhan, K Das, KC Mondal, ... Biologia 68 (6), 1072-1078 , 2013 2013 Citations: 8
Anti-hyperlipidemic effect of oils from Sesamum indicum L. and Vicia faba L. on male Wistar rats H Khatun, K Das, DK Nandi, J Laha, JS Rao, A Chattopadhyay Future Foods 4, 100060 , 2021 2021 Citations: 7
Protective effect of alpha-lipoic acid on hepato renal toxicity on acetaminophen induced uremic male albino rat S Pradhan, S Roy, S Mandal, K Das, S Das, DK Nandi European Journal of Biomedical 3 (5), 668-674 , 2016 2016 Citations: 7
