Sahebrao Boraste

@msgpharma.org

Associate Professor, Department of Pharmaceutics, Sir Dr MS Gosavi College of Pharmaceutical Education and Research.
Associate Professor

Sahebrao Boraste


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https://researchid.co/saheb2410

EDUCATION

M.Pharm (Pharmaceutics)

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science, Pharmacology, Toxicology and Pharmaceutics, Pharmacy, Polymers and Plastics
16

Scopus Publications

146

Scholar Citations

6

Scholar h-index

5

Scholar i10-index

Scopus Publications

  • Bioanalytical Method Development and its Validation by Using RP-HPLC for Determination of Trimetazidine Dihydrochloride in Human Plasma
    Sahebrao S. Boraste Boraste, Deelip V. Derle
    Research Journal of Pharmacy and Technology, 2025
    Trimetazidine dihydrochloride is used in the treatment of chest pain in angina condition. The study was performed to determine the bioavailability/bioequivalence of Trimetazidine in human plasma by utilising caffeine as an internal standard. Percent recoveries were obtained as 95.80 % w/v. for trimetazidine. The Liquid-Liquid extraction (LLE) technique was established for the optimal extraction of Trimetazidine and caffeine from biological matrix. The method involved chromatographic separation on Nucleosil C18 (150×4.6mm, 5µm) with mobile phase water, methanol, acetonitrile, and SHS buffer (60:40:10:03 v/v/v/v) at flow rate of 1.3 mL/min with 250C as ambient temperature and injection volume of 5µL. Quantitation was obtained using UV detection at 210 nm with retention times of 3.97 and 13.07 minutes for caffeine and Trimetazidine in plasma respectively. By applying statistics and performing recovery studies the method was validated showing a linearity concentration range of 5.04 - 201.60 ng/mL and a lower limit of quantification of 0.5 ng/mL. The method proved to be rapid, accurate, simple and precise, providing useful data for therapeutic drug monitoring in clinical laboratories and pharmacokinetics study.
  • Transforming clinical trials with AI integration in TNBC research
    Sahebrao Boraste, Sakshi Wani, Deelip Derle
    Artificial Intelligence Driven Precision Medicine for Triple Negative Breast Cancer Innovations and Insights in Tnbc Management, 2025
  • PEGylated Pharmaceutical Nanocarriers
    Prashant Pingale, Sakshi Wani, Sahebrao Boraste, Amarjitsing Rajput
    Pegylated Nanocarriers in Medicine and Pharmacy, 2025
  • Development of In Situ Nasal Gel of Moxifloxacin HCl for Brain Targeting: Design, Optimization and In-vitro Evaluation
    Khadija Akhlaque Siddiqui, Prashant Lakshaman Pingale, Sahebrao Sampat Boraste, Sunil Vishvnath Amrutkar, Dattatraya Manohar Shinkar
    Research Journal of Pharmacy and Technology, 2025
    Bacterial meningitis is a life-threatening infection of the meninges, often caused by Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae type b. Symptoms include high fever, headache, neck stiffness, photophobia, nausea, vomiting, and altered mental status. Diagnosis is confirmed via cerebrospinal fluid analysis, and treatment requires broad-spectrum intravenous antibiotics and corticosteroids. This study aimed to develop a thermoreversible in-situ nasal gel for Moxifloxacin HCl to enhance brain targeting and CNS absorption, reducing enzymatic breakdown and side effects. Using polymers like Xanthan gum, HPMC K4M, and Carbopol-940, the optimized gel demonstrated quick gelling, strong bioadhesion, and high ex-vivo absorption. Stability tests confirmed long-term efficacy. Further in-vivo research is needed to validate these results for meningitis treatment.
  • Formulation and Evaluation of Transdermal Patches of Clopidogrel Bisulfate
    Manisha Devram Gangurde, Dattatraya Manohar Shinkar, Sahebrao Sampat Boraste, Prashant Lakshaman Pingale, Sunil Vishvnath Amrutkar
    Research Journal of Pharmacy and Technology, 2025
    Transdermal medication delivery (TDDS) is a viable alternative to oral drug administration, offering benefits such as longer therapeutic efficacy, decreased side effects, enhanced bioavailability, improved patient compliance, and ease of drug therapy termination. A study using solvent casting method prepared nine formulations of transdermal patches using Eudragit L-100 and HPMC K4M as film forming polymers. The patches' weight, thickness, folding endurance, homogeneity of drug content, and moisture content were assessed, along with their organoleptic qualities.in-vitro release, and steady state flux. The optimized transdermal patch (F5) showed the highest drug content of 98.78%, with the highest drug release of 75.91%. The F5 batch showed the highest steady state flux of 2.922 𝝁g/cm² 12hr for clopidogrel bisulfate. The F5 batch completed three months of stability testing, showing no significant alterations to drug content, in vitro drug release, or steady state flux. The findings suggest that patches provide adequate outcomes for longer periods of time, and more clinical research is needed to establish an appropriate transdermal system for hypertension treatment.
  • Nutrition in skin health
    Dattatraya Shinkar, Anuradha Malode, Sahebrao Boraste, Sunil Amrutkar, Satish Rojekar
    Nutrition and Women S Health Functional Foods Nutraceuticals and Integrative Strategies, 2025
  • Formulation, Development, and Optimization of Cefpodoxime Proxetil Nanosuspension by using 23 Factorial Design
    Rakesh Sanjay Nath, Sahebrao Sampat Boraste, Dattatraya Manohar Shinkar, Sunil Vishvanath Amrutkar, Prashant Lakshaman Pingale
    Research Journal of Pharmacy and Technology, 2025
    The two main problems with most biologically active compounds are their slow rate of breakdown and their difficulty in dissolving in water. As a member of BCS class IV, cefpodoxime proxetil has limited permeability and solubility. To increase the drug's solubility and rate of dissolution, the current study set out to create Cefpodoxime proxetil nanosuspension utilizing a solvent evaporation technique. Zeta potential, particle size, total drug content, and entrapment efficiency were assessed for the created nanosuspension formulation. Various polymers were used to create stable nanosuspension over various trial batches. Following the findings of trial batches, the polyvinylpyrrolidone k30 was selected using a 23 factorial design for the production of cefpodoxime proxetil nanosuspension. With a %Entrapment efficiency of 96.16±0.55%, batch F4 exhibited the highest percentage among the analyzed formulation batches. Among the batches, the F4 batch has the highest total drug concentration, measuring 95.61±0.32%. Every batch of nanosuspension was assessed for several characteristics; batch F4 exhibited the lowest values for the maximum zeta potential (35.4 mV), polydispersity index (0.042 ± 0.01), and particle size (160.6 ± 1.2nm), in that order. For optimization, a linear model was mostly employed. The results of the ANOVA showed that the F4 batch was the most productive. Polyvinylpyrrolidone K30 and tween 80 were used to create a stable nanosuspension that improved the solubility and subsequent release of pure Cefpodoxime proxetil medication.
  • Nutraceuticals and Psoriasis: Recent Scientific Evidence in Clinical Trials
    Nutraceuticals in Arthritis and Psoriasis Management and Prevention of Diseases, 2025
  • Formulation, Optimization, and Evaluation of Transdermal Patches of Clotrimazole and Betamethasone Dipropionate for Candidiasis
    Shivani A. Wable, Prashant Pingale, D. M. Shinkar, Sahebrao Sampat Boraste, Sunil V. Amrutkar
    Research Journal of Pharmacy and Technology, 2024
    The most effective way to minimize the undesirable side effects of an overdose and to maximize both therapeutic benefits and patient compliance is through TDDS. Due to first-pass metabolism, clotrimazole possesses antifungal action and a half-life of two hours. It has to be dosed frequently. Betamethasone Dipropionate gives anti-inflammatory effect to reduce symptoms of candidiasis. To prolong the release, increase the drug's bioavailability, and increase patient compliance, a transdermal patch containing Clotrimazole and Betamethasone Dipropionate was developed. By adjusting the polymer concentrations through the solvent casting process, various formulations were created. The generated formulations conducted evaluations for several factors, including drug excipient compatibility, drug content, thickness, weight variation, folding durability, moisture uptake, moisture loss, and in vitro drug release. A 32 complete factorial design was used to examine the impact of various polymer concentrations on the reactions of clotrimazole and betamethasone dipropionate, including moisture uptake and percentage of medication released in 12 hours. To determine the kinetics of drug release, in vitro release data were fitted to various models. Batch F5 was considered optimum batch which contained HPMC K4M and Eudragit L-100 in concentrations of 350 and 250 mg respectively. For clotrimazole and betamethasone dipropionate, formulation F5 was shown to have the maximum drug release 75.91% and 67.09%, respectively. The created F5 had the highest drug content, with clotrimazole and betamethasone dipropionate concentrations of 98.78% and 98.82%, respectively.
  • Nanocarriers in ulcerative colitis
    Sachin Kothawade, Vishal Pande, Dattatraya Shinkar, Prashant Pingale, Sahebrao Boraste
    Nanocarrier Drug Delivery Systems Therapeutic and Diagnostic Medicine, 2024
    This chapter explores the promising role of nanocarriers in the management of ulcerative colitis (UC), a chronic inflammatory bowel disease. UC presents a significant clinical challenge due to its complex pathophysiology and the limitations of conventional treatment strategies. Nanocarriers, including lipid-based, polymeric, and inorganic nanoparticles (NPs), offer a novel approach to UC therapy by improving drug bioavailability, enabling targeted delivery, reducing systemic side effects, and providing controlled drug release. Nanocarriers are tiny structures that can encapsulate therapeutic drugs and protect them from degradation, enabling their precise delivery to specific target locations in the body. Preclinical and clinical studies have demonstrated the potential of nanocarriers to improve the efficacy and safety of UC treatment. Nanocarriers have also been used to deliver other therapeutic agents for UC, such as corticosteroids, immunomodulators, and biologics. Despite the promising results, there are still some challenges that need to be addressed before nanocarriers can be widely used in the clinic for UC treatment. These challenges include optimizing the design and delivery of nanocarriers, ensuring their safety and efficacy in the long term, and developing cost-effective manufacturing processes. Nanocarriers are a promising new therapeutic modality for UC. They have the potential to overcome the limitations of conventional treatment strategies and provide more effective and safer care for patients with this chronic disease.
  • Nanocarriers for treatment of parkinson's disease
    Dattatraya Shinkar, Prashant Pingale, Sahebrao Boraste, Raosaheb Ghegade, Sunil Amrutkar
    Nanocarrier Drug Delivery Systems Therapeutic and Diagnostic Medicine, 2024
  • Polymers Used in Personalized Medicines
    Sahebrao Boraste, Kartiki Bhandari, Deeliprao Derle, Prashant Pingale
    Polymers in Modern Medicine Part 2, 2024
  • Advancement and Authentication of Spectrophotometric Method for Detection of Losartan Potassium
    Y. S. Chavan, D. M. Shinkar, S. S. Jadhav, S. S. Boraste, P. L. Pingale, S. V. Amrutkar
    Chemistry Africa, 2022
  • Formulation, Evaluation and Characterization of Mouth Dissolving Film of Cisapride
    Current Trends in Biotechnology and Pharmacy, 2022
  • In-silico trials alternative in-vivo animal studies: Potentiality, predictive modelling, and realism
    Pingale, Prashant
    Journal of Current Science and Technology, 2021
  • Formulation and evaluation of pravastatin fast disintegrating tablets using natural superdisintegrant
    and Prashant L Pingale
    Journal of Medical Pharmaceutical and Allied Sciences, 2021

RECENT SCHOLAR PUBLICATIONS

  • Current Perspectives on Novel Drug Delivery System for Prostate Cancer
    DVD Dattatraya M. Shinkar, Sahebrao S. Boraste, Sakshi P. Wani, Prashant L ...
    Apple Academic Press , 2026
    2026
  • . Renal Kidney-Targeted Drug Delivery System: Future Aspects
    DVD Dattatraya M. Shinkar, Sahebrao S. Boraste, Sakshi P. Wani, Prashant L ...
    Apple Academic Press , 2026
    2026
  • Tumor-Targeted Drug Delivery in Gastric Cancer
    DVD Sahebrao S. Boraste, Dattatraya M. Shinkar, Sakshi P. Wani, Raosaheb Y ...
    Apple Academic Press , 2026
    2026
  • Silybum marianum Extract Composed Medicated Bath Bomb Formulation for Topical Use
    SVA Raosaheb Y. Ghegade,Vinitee M. Mahale,Aditya K. Patil,Sahebrao S. Boraste
    IN Patent App. 202521093242 A , 2026
    2026
  • Nutrition in skin health
    D Shinkar, A Malode, S Boraste, S Amrutkar, S Rojekar
    Nutrition and Women's Health, 275-287 , 2026
    2026
  • Nutrition in skin health
    SA Dattatraya Shinkar1 , Anuradha Malode1 , Sahebrao Boraste1
    Nutrition and Women’s Health , 2026
    2026
  • Transforming clinical trials with AI integration in TNBC research
    S Boraste, S Wani, D Derle
    Artificial Intelligence-Driven Precision Medicine for Triple Negative Breast … , 2026
    2026
  • Formulation, Development, and Optimization of Cefpodoxime Proxetil Nanosuspension by using 23 Factorial Design
    PLP Rakesh Sanjay Nath, Sahebrao Sampat Boraste, Dattatraya Manohar Shinkar ...
    Research Journal of Pharmacy and Technology 18 (6), 2774 , 2025
    2025
  • Formulation and Evaluation of Transdermal Patches of Clopidogrel Bisulfate
    SVA Manisha Devram Gangurde1, Dattatraya Manohar Shinkar1*, Sahebrao Sampat ...
    Research Journal of Pharmacy and Technology 18 (12), 5626-5632 , 2025
    2025
  • Formulation Strategies for Controlled Drug Release Using MUPS Tablets: Advances and Challenges
    SSBDV Derle
    Biosciences Biotechnology Research Asia 22 (3) , 2025
    2025
    Citations: 1
  • Development of In Situ Nasal Gel of Moxifloxacin HCl for Brain Targeting: Design, Optimization and In-vitro Evaluation
    KA Siddiqui, PL Pingale, SS Boraste, SV Amrutkar, DM Shinkar
    Research Journal of Pharmacy and Technology 18 (10), 5003-5010 , 2025
    2025
  • Development of In Situ Nasal Gel of Moxifloxacin HCl for Brain Targeting: Design, Optimization and In-vitro Evaluation
    DMS Khadija Akhlaque Siddiqui, Prashant Lakshaman Pingale, Sahebrao Sampat ...
    Research Journal of Pharmacy and Technology 18 (10), 5002-5010 , 2025
    2025
  • Bioanalytical Method Development and its Validation by Using RP-HPLC for Determination of Trimetazidine Dihydrochloride in Human Plasma
    DVD Sahebrao S. Boraste
    Research Journal of Pharmacy and Technology 18 (10), 4790-4. , 2025
    2025
  • Topical Film-Forming Spray Formulation of Clobetasol Propionate for Enhanced Transdermal Delivery
    MPGTMSS Boraste
    IN Patent App. 202521077058 A , 2025
    2025
  • Nutraceuticals and Psoriasis: Recent Scientific Evidence in Clinical Trials
    A Jadhav, M Bele, S Boraste, R Ahire, ED Ahire, M Jaiswal, RK Keservani, ...
    Nutraceuticals in Arthritis and Psoriasis, 227-244 , 2025
    2025
  • : A bioactive film composition for incorporation into sanitary pads
    MSS Boraste
    IN Patent App. 202521057239 A , 2025
    2025
  • PEGylated pharmaceutical nanocarriers
    P Pingale, S Wani, S Boraste, A Rajput
    PEGylated Nanocarriers in Medicine and Pharmacy, 1-28 , 2025
    2025
    Citations: 2
  • Nutraceuticals and Psoriasis: Recent Scientific Evidence in Clinical Trials
    SGT JAbhish Jadhav, Mrudula Bele, Sahebrao Boraste, Rohan Ahire, Eknath D ...
    Taylor and Francis , 2025
    2025
  • Polymers Used in Personalized Medicines
    S Boraste, K Bhandari, D Derle, P Pingale
    Polymers in Modern Medicine-Part 2, 1-25 , 2024
    2024
  • Development and validation of Dissolution method for Trimetazidine HCl in Modified Release formulation by RP-HPLC
    DVD Sahebrao S. Boraste
    International Journal of Pharmaceutical Quality Assurance 15 (4), 2682-2690 , 2024
    2024

MOST CITED SCHOLAR PUBLICATIONS

  • Solanum nigrum Linn: A phytopharmacological review
    SE Potawale, SD Sinha, KK Shroff, HJ Dhalawat, SS Boraste, SP Gandhi, ...
    Pharmacologyonline 3, 140-63 , 2008
    2008
    Citations: 42
  • Spectrophotometric method development and validation of itopride hydrochloride in bulk and dosage form
    SU Zate, PI Kothawade, JW Gajbe, AS Pramod, SS Boraste
    International Journal of Drug Delivery 2 (4) , 2010
    2010
    Citations: 17
  • Bioanalysis-method development, validation, sample preparation, its detection techniques and its application
    SR Nikam, AS Jagdale, SS Boraste, SB Patil
    Asian Journal of Pharmaceutical Analysis 11 (4) , 2021
    2021
    Citations: 14
  • Preliminary evaluation of Bauhinia racemosa Lam caesalpinaceae seed mucilage as tablet binder
    AB Gangurde, SS Boraste
    Int J Pharm 2 (1), 80-83 , 2012
    2012
    Citations: 14
  • Formulation, Evaluation, and Optimization of Glimepiride Nanosuspension by Using Antisolvent Evaporation Technique
    PLP Dattatraya M. Shinkar, Sonal Sanjay Jadhav,Sahebrao Sampat Boraste
    Pharmacophore 13 (4) , 2022
    2022
    Citations: 11
  • A simple glance at the transdermal drug delivery system
    YS Chavan, DM Shinkar, SS Jadhav, PL Pingale, SS Boraste, ...
    Pharmacophore 13 (3-2022), 72-80 , 2022
    2022
    Citations: 8
  • Ethosomes—Newer Trend in Transdermal Drug Delivery: A Review
    P Pingale
    Int. J. Pharma Res. Health Sci 6, 2586-2590 , 2018
    2018
    Citations: 6
  • MICROSPONGES: AN EMERGING FORMULATION TOOL FOR TOPICAL DRUG DELIVERY
    SSB Sakshi Pravin Wani , Dattatraya Manohar Shinkar, Prashant Laxman Pingale
    Pharmacophore 13 (6), 14 , 2022
    2022
    Citations: 5
  • Solid lipid nanoparticles a potential approach for delivery of lipophilic drugs: A review
    AT Nair, SS Deshkar, SS Boraste, RM Sharma
    J. Pharm. Pharm. Sci 5, 2238-2253 , 2016
    2016
    Citations: 5
  • Formulation, Evaluation and Characterization of Mouth Dissolving Film of Cisapride
    PL Pingale, DM Shinkar, SS Boraste, SV Amrutkar
    Current Trends in Biotechnology and Pharmacy 16 (4), 490-499 , 2022
    2022
    Citations: 4
  • Formulation and evaluation of pravastatin fast disintegrating tablets using natural superdisintegrant
    PL Pingale, SS Boraste, SV Amrutkar
    J med Pharm Allied Sci 10 (3), 2977-81 , 2021
    2021
    Citations: 4
  • Advancement and Authentication of Spectrophotometric Method for Detection of Losartan Potassium
    PLPSVA Y. S. Chavan, D. M. Shinkar, S. S. Jadhav, S. S. Boraste
    Chemistry Africa springer, 1-6 , 2022
    2022
    Citations: 3
  • Gene-Specific Drug Delivery System: An Art of War
    PLPSVA Neetu R. Saudagar, Sahebrao S. Boraste, Dattatray M. Shinkar
    BIOSCIENCES BIOTECHNOLOGY RESEARCH ASIA 19 (2), 459-471 , 2022
    2022
    Citations: 3
  • A Systematic Review on Hair Care and Herbs Used in Hair Fall Treatment
    SVA PL Pingale, SS Boraste
    nternational Journal of Ayurveda and Pharmaceutical Chemistry 5 (1), 26-42 , 2016
    2016
    Citations: 3
  • PEGylated pharmaceutical nanocarriers
    P Pingale, S Wani, S Boraste, A Rajput
    PEGylated Nanocarriers in Medicine and Pharmacy, 1-28 , 2025
    2025
    Citations: 2
  • Formulation Strategies for Controlled Drug Release Using MUPS Tablets: Advances and Challenges
    SSBDV Derle
    Biosciences Biotechnology Research Asia 22 (3) , 2025
    2025
    Citations: 1
  • Formulation, Optimization, and Evaluation of Transdermal Patches of Clotrimazole and Betamethasone Dipropionate for Candidiasis
    SVAF hivani A. Wable, Prashant L. Pingale, Dattatray M. Shinkar, Sahebrao S ...
    Research Journal of Pharmacy and Technology 17 (9), 4267-4 , 2024
    2024
    Citations: 1
  • A systematic review on micronutrients in memory: feeding the brain.
    A Bhoir, R Patil, S Boraste, P Pingale, S Amrutkar
    2022
    Citations: 1
  • Nanofibers in Drug Delivery System
    SR Dawange, SS Boraste, PL Pingale, SV Amrutkar
    Asian Journal of Pharmaceutical Research and Development 9 (4), 151-157 , 2021
    2021
    Citations: 1
  • Bioanalytical method development and validation of azilsartan medoxomil potassium in human plasma by reversed-phase high-performance liquid chromatography with solid-phase …
    SR Nikam, AS Jagdale, SS Boraste
    Int J Med Sci 5 (2), 32 , 2021
    2021
    Citations: 1