A Review on Structurally Diversified Synthesized Molecules as Monoacyl-glycerol Lipase Inhibitors and their Therapeutic uses Abhishek Kashyap, Suresh Kumar, Rohit Dutt Current Drug Research Reviews, 2022 Monoacylglycerol is a metabolic key serine hydrolase engaged in the regulation of the signalling network system of endocannabinoids, which is associated with various physiological processes like pain, inflammation, feeding cognition, and neurodegenerative diseases like Alzheimer’s and Parkinson’s disease. The monoacylglycerol was also found to act as a regulator and the free fatty acid provider in the proliferation of cancer cells as well as numerous aggressive tumours such as colorectal cancer, neuroblastoma, and nasopharyngeal carcinoma. It also played an important role in increasing the concentration of specific lipids derived from free fatty acids like phosphatidic acid, lysophosphatidic acid, sphingosine-1-phosphate, and prostaglandin E2. These signalling lipids are associated with cell proliferation, survival, tumour cell migration, contribution to tumour development, maturation, and metastases. In this study, we present a review on structurally diverse MAGL inhibitors, their development, and their evaluation for different pharmacological activities.
RECENT SCHOLAR PUBLICATIONS
DESIGN AND COMPUTATIONAL EVALUATION OF NEW CARBAMATE DERIVATIVES FOR THE INHIBITION OF MONOACYLGLYCEROL LIPASE ENZYME BY USING DOCKING A Kashyap, D Rani, S Kumar, S Bhatt 2023
A Review on Structurally Diversified Synthesized Molecules as Monoacylglycerol Lipase Inhibitors and their Therapeutic uses A Kashyap, S Kumar, R Dutt Current Drug Research Reviews Formerly: Current Drug Abuse Reviews 14 (2 … , 2022 2022 Citations: 8
Studies of effects of changes of different features in ligand Scaffold and screening of newly designed carbamate derivatives for the treatment of carcinomas A Kashyap, D Rani, S Kumar, R Dutt NeuroQuantology 20 (15), 147 , 2022 2022
IDENTIFICATION OF POTENTIAL MAGL INHIBITORS USING MOLECULAR DOCKING SCREENING AS ANTI-CANCER AGENTS A Kashyap, D Rani, S Kumar, R Dutt NeuroQuantology 20 (12), 3469 , 2022 2022
MOST CITED SCHOLAR PUBLICATIONS
A Review on Structurally Diversified Synthesized Molecules as Monoacylglycerol Lipase Inhibitors and their Therapeutic uses A Kashyap, S Kumar, R Dutt Current Drug Research Reviews Formerly: Current Drug Abuse Reviews 14 (2 … , 2022 2022 Citations: 8
DESIGN AND COMPUTATIONAL EVALUATION OF NEW CARBAMATE DERIVATIVES FOR THE INHIBITION OF MONOACYLGLYCEROL LIPASE ENZYME BY USING DOCKING A Kashyap, D Rani, S Kumar, S Bhatt 2023
Studies of effects of changes of different features in ligand Scaffold and screening of newly designed carbamate derivatives for the treatment of carcinomas A Kashyap, D Rani, S Kumar, R Dutt NeuroQuantology 20 (15), 147 , 2022 2022
IDENTIFICATION OF POTENTIAL MAGL INHIBITORS USING MOLECULAR DOCKING SCREENING AS ANTI-CANCER AGENTS A Kashyap, D Rani, S Kumar, R Dutt NeuroQuantology 20 (12), 3469 , 2022 2022
