Dr NARKHEDE HEMANT P.

@pkkotecha.org

Associate Professor Chemistry Department
SSVPMS SMT.P.K.KOTECHA MAHILA MAHAVIDYALAYA BHUSAWAL MAHARASHTRA INDIA

Dr NARKHEDE HEMANT P.


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https://researchid.co/narkhedehemant68

EDUCATION

Ph.D M. M.

RESEARCH, TEACHING, or OTHER INTERESTS

Chemistry, Organic Chemistry, Agricultural and Biological Sciences, Analytical Chemistry
19

Scopus Publications

155

Scholar Citations

6

Scholar h-index

6

Scholar i10-index

Scopus Publications

  • ACCELERATED DISCOVERY OF BIOACTIVE 3-CHLORO-2-HYDRAZINYLPYRIDINE DERIVATIVES VIA CONTINUOUS FLOW SYNTHESIS IN A ROTOR-STATOR SPINNING DISC REACTOR
    M. J Pimpale, H. P Narkhede
    Rasayan Journal of Chemistry, 2026
    Creating heterocyclic compounds that can be used for medicine is an important area of study in medicinal chemistry. This study shows how to create new 3-chloro-2-hydrazinylpyridine compounds in a special machine called a rotor- stator spinning disc reactor (RS-SDR). The special design of the RS-SDR allows for better mixing, efficient heat transfer, and accurate control of reaction conditions, making it easier and quicker to produce hydrazinylpyridinecompounds in larger amounts. By carefully designing molecules and adjusting the process conditions, we were ableto produce a lot of high-quality products in a safe and eco-friendly way. Our method is much faster and works better than traditional batch processes, even when solid materials are involved. Testing of certain compounds showedthat they have good abilities to fight germs and reduce inflammation. This suggests they could be important startingpoints for creating new medicines. These results show how combining continuous flow chemistry with designingring-shaped chemical structures can create useful molecules more sustainably and efficiently. This work shows howthe RS-SDR is a useful tool for speeding up the process of finding new drugs by allowing for environmentallyfriendly and larger-scale production.
  • Design and Synthesis of Novel 2-Chloro-5-(chloromethyl)pyridine Bioactive Derivatives by Rapid and Efficient Continuous Flow Reaction Module
    Milind J. Pimpale, Suvidha R. Phalak, Hemant P. Narkhede
    Asian Journal of Chemistry, 2025
    This study explores the synthesis of new bioactive compounds from the key intermediate 2-chloro-5-(hydrazinylmethyl)pyridine by reacting with various aromatic aldehydes. The process started with 2-chloro-5-(chloromethyl)pyridine, which was used in a flow reactor for a continuous and efficient reaction. The key intermediate, 2-chloro-5-(hydrazinylmethyl)pyridine, was synthesized via a straightforward method and then reacted with aromatic aldehydes under mild conditions to form hydrazone compounds. The compounds were characterized with FTIR, NMR and mass spectroscopic techniques. Preliminary testing showed the promising biological activities, including potential antimicrobial and anti-malarial effects, suggesting their utility in the drug development.
  • A validated eco-friendly, operation-safe, and cost-effective RP-HPLC method for the determination of dodine in their pesticide dosage forms using ethanol:water as mobile phase
    Vilas Patil, Dipak Dalal, Kishor Phatangare, Suresh Bagul, Hemant Narkhede
    International Journal of Environmental Analytical Chemistry, 2024
    A validated simple reverse-phase high-performance liquid chromatographic – diode array detection (HPLC–DAD) method was optimised for the analysis of dodine in their pesticide dosage forms by replacing more hazardous acetonitrile and methanol with safe ethanol. The chromatographic analysis was achieved on the Waters, Symmetry C8 column (150 mm × 4.6 mm; 5 µm) using an eco-friendly isocratic eluent; ethanol: water (containing 0.1% v/v trifluoroacetic acid) (50:50, v/v) as the mobile phase with the flow rate of 1.0 mL/minute. The detector wavelength was set at 205 nm. The method was validated as per the SANCO (Directorate-General Health and Consumer Protection) and ICH (International conference on harmonisation) guidelines. The calibration curve showed a good correlation coefficient (0.9998) over the concentration range of 20.04 to 180.34 mg/L. The method was highly precise and robust with a relative standard deviation value of less than 2%. The limit of detection (LOD) and limit of quantification (LOQ) was between 0.80 and 2.40 mg/L, respectively. The extraction recovery of the analyte ranged from 99.38% to 102.00%. Assessment results proved that our analytical method is considered an eco-friendly alternative to conventionally reported methods regarding usage of safe solvents and chemicals, a minimal amount of waste production, and a short time of analysis. Accordingly, the proposed method could be readily applied for quality control purposes as an eco-friendly, simple, and efficient analytical tool.
  • A simple and rapid reverse-phase high-performance liquid chromatographic method for the determination of propineb and tricyclazole pesticides from the wettable powder formulation
    Vilas K. Patil, Jayant G. Chandorkar, Devender T. Seshadri, Jitendra G. Patil, Narendra H. Petha, Tanaji S. Bhagat, Hemant P. Narkhede
    Journal of the Iranian Chemical Society, 2023
  • Determination of Acephate, Dinotefuran, and Emamectin Benzoate in a Pesticide Formulation: A Single-Laboratory Validation
    Vilas K Patil, Jayant G Chandorkar, Yogesh B Wagh, Yogesh B More, Hemant P Narkhede
    Journal of AOAC International, 2023
    Background The advantage of simultaneous separation and quantification is the reduction of analysis time and consumption of solvents and reagents. Objective The objective of the present investigation was to optimize and validate a novel, rapid, and simple reverse-phase high-performance liquid chromatographic method for the simultaneous determination of acephate, dinotefuran, and emamectin benzoate in a pesticide formulation. Method The chromatographic separation and quantification were accomplished by using Kromasil CN column (250 mm × 4.6 mm; 5 μm) with a mobile phase consisting of acetonitrile and water [0.1% (v/v) triethylamine, pH 2.7 with 10% (v/v) orthophosphoric acid] in the ratio of 50:50 (v/v) with a flow rate of 1.0 mL/min and diode array detection at the wavelength of (215 nm and 245 nm). Results The HPLC method was able to separate and quantify all the actives in the formulation by isocratic elution within 10 min. The method was fully validated in accordance with the SANCO and Collaborative International Pesticide Analytical Council guidelines concerning system suitability, specificity, linearity, precision, accuracy, and robustness. All the analytical parameters are within the range of acceptable limits in the guidelines. Conclusions The validated method was successfully applied to a pesticide formulation. Highlights The novelty of the current research work lies in the development of the simple and rapid HPLC method for simultaneous determination of acephate, dinotefuran, and emamectin benzoate in wettable granular formulation.
  • An Exploration of ChCl/Glycerol-Based Deep Eutectic Solvent as a Sustainable Reaction Medium for the Synthesis of Biologically Important Aminopyrazole and Aminopyrazolone Compounds
    Jayashri D. Bhirud, Gaurav R. Gupta, Hemant P. Narkhede
    Current Bioactive Compounds, 2022
    Objectives: the synthesis of 4-((1-phenyl-3-(substitutedphenyl)-1h-pyrazol-4-yl) methylene)- 4h-pyrazol-3,5-diamine and 3-amino-4-((1-phenyl-3-(substitutedphenyl)-1h-pyrazol-4-yl) methylene)-1h-pyrazol-5(4h)-one was designed and performed very aptly in deep eutectic solvent system. Methods: the utilization of deep eutectic solvent (des) system chcl/gly (1:2) in the absence of hazardous organic co-solvents, an efficient multicomponent one-pot synthetic strategy has been advanced. In addition to that, from the perspectives of sustainable developments in organic synthesis, the deep eutectic solvent system was recovered and very efficiently reused up to four cycles. Results: it has been observed that the efficacy of the deep eutectic solvent was decreased after the second cycle, which has a measurable impact on the yield of the reaction. Conclusion: furthermore, the synthesized aminopyrazole and aminopyrazolone compounds were screened as antibacterial and antifungal agents.
  • A novel validated simple derivatization liquid chromatographic method with diode array detection for the simultaneous determination of mancozeb, azoxystrobin and difenoconazole in pesticide dosage form
    Vilas K. Patil, Ujwala B. Wagh, Raju P. Phalak, Jayashri D. Bhirud, Hemant P. Narkhede
    Analytical Methods, 2022
    A novel, rapid and simple reverse-phase high performance liquid chromatography (RP-HPLC) method for the simultaneous determination of three pesticides – mancozeb, azoxystrobin and difenoconazole by derivatization with ethyl iodide is presented.
  • A simple derivatization RP-HPLC method for the simultaneous determination of zineb and hexaconazole in pesticide formulation using a PDA detector
    Vilas K. Patil, Nilesh D. Dhande, Narendra H. Petha, Hemant P. Narkhede
    Analytical Methods, 2021
    A simple derivatization reverse-phase high performance liquid chromatographic method for the simultaneous analysis (separation and quantification) of zineb and hexaconazole has been optimized and validated.
  • Synthesis and biological activity of 7-(2-(1H-1,2,4-triazol-1-yl)ethoxy)-4-(styryl/4-substituted styryl)-2H-chromen-2-one
    Indian Journal of Chemistry Section B Organic and Medicinal Chemistry, 2021
  • Sulfamic acid catalyzed synthesis of new 3,5-[(sub)phenyl]-1H-pyrazole bearing N1-isonicotinoyl: And their pharmacological activity evaluation
    Jayashri D. Bhirud, Rajendra D. Patil, Hemant P. Narkhede
    Bioorganic and Medicinal Chemistry Letters, 2020
  • Oxidative Cyclization of Chalcones in the Presence of Sulfamic Acid as Catalyst. Synthesis, Biological Activity, and Thermal Properties of 1,3,5-Trisubstituted Pyrazoles
    J. D. Bhirud, G. R. Gupta, H. P. Narkhede
    Russian Journal of Organic Chemistry, 2020
  • An Expeditious and Facile Synthesis of Isoxazole Derivatives in Deep Eutectic Solvent
    Indian Journal of Heterocyclic Chemistry, 2020
  • Solid supported synthesis of bio-active dimeric alkylene and diketoalkylene 9H-carbazole compounds via greener methodology
    International Journal of Chemical Sciences, 2014
  • Polymer supported synthesis of bioactive heterocyclic compounds
    Indian Journal of Heterocyclic Chemistry, 2009
  • Synthesis of new dimeric carvacrol compounds
    Organic Communications, 2008
  • Solid supported synthesis of 2-mercaptobenzimidazole derivatives using microwaves
    Journal of Scientific and Industrial Research, 2008
  • Solid-supported synthesis of bio-active carvacrol compounds using microwaves
    H. P. Narkhede, U. B. More, D. S. Dalal, P. P. Mahulikar
    Synthetic Communications, 2008
  • Synthesis of biologically active carvacrol compounds using different solvents and supports
    U. B. More, H. P. Narkhede, D. S. Dalal, P. P. Mahulikar
    Synthetic Communications, 2007
  • Fly-ash-supported synthesis of 2-mercaptobenzothiazole derivatives under microwave irradiation
    Hemant P. Narkhede, Uttam B. More, Dipak S. Dalal, Nilesh S. Pawar, Dhananjay H. More, Pramod P. Mahulikar
    Synthetic Communications, 2007

RECENT SCHOLAR PUBLICATIONS

  • Efficient synthesis of azoxystrobin and its key intermediate using a newer DABCO-based catalyst
    ND Dhande, TT Pansare, UV Baviskar, HP Narkhede
    European Journal of Chemistry 17 (1), 19-25 , 2026
    2026
  • A validated eco-friendly, operation-safe, and cost-effective RP-HPLC method for the determination of dodine in their pesticide dosage forms using ethanol: water as mobile phase
    V Patil, D Dalal, K Phatangare, S Bagul, H Narkhede
    International Journal of Environmental Analytical Chemistry 104 (18), 6358-6369 , 2024
    2024
    Citations: 2
  • A simple and rapid reverse-phase high-performance liquid chromatographic method for the determination of Propineb and Tricyclazole pesticides from the wettable powder formulation
    VK Patil, JG Chandorkar, DT Seshadri, JG Patil, NH Petha, TS Bhagat, ...
    Journal of the Iranian Chemical Society 20 (10), 2587-2594 , 2023
    2023
    Citations: 2
  • Determination of Acephate, Dinotefuran, and Emamectin benzoate in a pesticide formulation: a single-laboratory validation
    VK Patil, JG Chandorkar, YB Wagh, YB More, HP Narkhede
    Journal of AOAC International 106 (3), 523-533 , 2023
    2023
    Citations: 3
  • An Exploration of ChCl/Glycerol-Based Deep Eutectic Solvent as a Sustainable Reaction Medium for the Synthesis of Biologically Important Aminopyrazole and Aminopyrazolone Compounds
    JD Bhirud, GR Gupta, HP Narkhede
    Current Bioactive Compounds 18 (9), 50-60 , 2022
    2022
    Citations: 2
  • A novel validated simple derivatization liquid chromatographic method with diode array detection for the simultaneous determination of mancozeb, azoxystrobin and difenoconazole …
    VK Patil, UB Wagh, RP Phalak, JD Bhirud, HP Narkhede
    Analytical Methods 14 (9), 907-920 , 2022
    2022
    Citations: 3
  • A simple derivatization RP-HPLC method for the simultaneous determination of zineb and hexaconazole in pesticide formulation using a PDA detector
    VK Patil, ND Dhande, NH Petha, HP Narkhede
    Analytical Methods 13 (35), 3930-3939 , 2021
    2021
    Citations: 11
  • Synthesis and biological activity of 7-(2-(1H-1, 2, 4-triazol-1-yl) ethoxy)-4-(styryl/4-substituted styryl)-2H-chromen-2-one
    JD Bhirud, YB More, PD Baviskar, HP Narkhede
    Indian J. Chem. B 60, 1097-1102 , 2021
    2021
    Citations: 2
  • Sulfamic acid catalyzed synthesis of new 3, 5-[(sub) phenyl]-1H-pyrazole bearing N1-isonicotinoyl: and their pharmacological activity evaluation
    JD Bhirud, RD Patil, HP Narkhede
    Bioorganic & Medicinal Chemistry Letters 30 (23), 127558 , 2020
    2020
    Citations: 11
  • Oxidative cyclization of chalcones in the presence of sulfamic acid as catalyst. synthesis, biological activity, and thermal properties of 1, 3, 5-trisubstituted pyrazoles
    JD Bhirud, GR Gupta, HP Narkhede
    Russian Journal of Organic Chemistry 56 (10), 1815-1822 , 2020
    2020
    Citations: 6
  • An Expeditious and Facile Synthesis of Isoxazole Derivatives in Deep Eutectic Solvent
    JD Bhirud, HP Narkhede
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 30 (3), 421-424 , 2020
    2020
    Citations: 1
  • Antibacterial activity of copper nanoparticles
    YB More, HP Narkhede
    BIOINFOLET-A Quarterly Journal of Life Sciences 17 (1b), 144-144 , 2020
    2020
  • ANTIBACTERIALACTIVITYOF COPPER NANOPARTICLES
    YBMHP Narkhede
    BIOINFOLET 17 17 ((1B)), 144 , 2020
    2020
  • Synthesis of (thiazol-2-yl) diazenyl) derivatives from 2-amino thiazole and their solvatochromism study
    JD Bhirud, HP Narkhede
    2019
  • SYNTHESIS AND CHARACTERIZATION OF OPTIMIZED NANO-EMULGEL MICELLES AS A VEHICLE OF PLANT EXTRACTED CURCUMIN: DRUG RELEASE AND IN VITRO STUDY
    PD Baviskar, HP Narkhede
    2019
  • Synthesis of 4-(2-(substituted phenyl) diazenyl)-1-phenylpyrazolidine-3, 5-dione catalyzed by L-proline and their biological activity
    JD Bhiruda, PP Mahulikarb, HP Narkhede
    Indian Journal of Chemistry 57, 1208-1212 , 2018
    2018
    Citations: 2
  • Potassium Dihydrogen Phosphate: An Inexpensive Catalyst for the Synthesis of 2, 4, 5-TrisubstitutedImidazoles under Solvent Free Condition, J
    JD Bhirud, HP Narkhede
    Applicable Chem 5 (5), 1075-1079 , 2016
    2016
    Citations: 6
  • Solid supported synthesis of bio-active dimeric alkylene and diketoalkylene 9H-carbazole compounds via greener methodology
    HP Narkhede
    International Journal 12, 551-556 , 2014
    2014
    Citations: 2
  • Polymer supported synthesis of bioactive heterocyclic compounds
    UB More, HP Narkhede, CN Raut, PP Mahulikar
    Indian Journal of Heterocyclic Chemistry 19 (1), 43-46 , 2009
    2009
  • Synthesis of new dimeric carvacrol compounds.
    UB More, HP Narkhede, PP Mahulikar
    Organic Communications 1 (4) , 2008
    2008
    Citations: 2

MOST CITED SCHOLAR PUBLICATIONS

  • Fly‐Ash‐Supported Synthesis of 2‐Mercaptobenzothiazole Derivatives under Microwave Irradiation
    HP Narkhede, UB More, DS Dalal, NS Pawar, DH More, PP Mahulikar
    Synthetic communications 37 (4), 573-577 , 2007
    2007
    Citations: 41
  • Solid supported synthesis of 2-mercaptobenzimidazole derivatives using microwaves
    HP Narkhede, UB More, DS Dalal, PP Mahulikar
    Journal of Scientific and Industrial Research 67 (5), 374 , 2008
    2008
    Citations: 25
  • Solid-supported synthesis of bio-active carvacrol compounds using microwaves
    HP Narkhede, UB More, DS Dalal, PP Mahulikar
    Synthetic Communications® 38 (14), 2413-2418 , 2008
    2008
    Citations: 17
  • Synthesis of biologically active carvacrol compounds using different solvents and supports
    UB More, HP Narkhede, DS Dalal, PP Mahulikar
    Synthetic Communications 37 (12), 1957-1964 , 2007
    2007
    Citations: 17
  • A simple derivatization RP-HPLC method for the simultaneous determination of zineb and hexaconazole in pesticide formulation using a PDA detector
    VK Patil, ND Dhande, NH Petha, HP Narkhede
    Analytical Methods 13 (35), 3930-3939 , 2021
    2021
    Citations: 11
  • Sulfamic acid catalyzed synthesis of new 3, 5-[(sub) phenyl]-1H-pyrazole bearing N1-isonicotinoyl: and their pharmacological activity evaluation
    JD Bhirud, RD Patil, HP Narkhede
    Bioorganic & Medicinal Chemistry Letters 30 (23), 127558 , 2020
    2020
    Citations: 11
  • Oxidative cyclization of chalcones in the presence of sulfamic acid as catalyst. synthesis, biological activity, and thermal properties of 1, 3, 5-trisubstituted pyrazoles
    JD Bhirud, GR Gupta, HP Narkhede
    Russian Journal of Organic Chemistry 56 (10), 1815-1822 , 2020
    2020
    Citations: 6
  • Potassium Dihydrogen Phosphate: An Inexpensive Catalyst for the Synthesis of 2, 4, 5-TrisubstitutedImidazoles under Solvent Free Condition, J
    JD Bhirud, HP Narkhede
    Applicable Chem 5 (5), 1075-1079 , 2016
    2016
    Citations: 6
  • Determination of Acephate, Dinotefuran, and Emamectin benzoate in a pesticide formulation: a single-laboratory validation
    VK Patil, JG Chandorkar, YB Wagh, YB More, HP Narkhede
    Journal of AOAC International 106 (3), 523-533 , 2023
    2023
    Citations: 3
  • A novel validated simple derivatization liquid chromatographic method with diode array detection for the simultaneous determination of mancozeb, azoxystrobin and difenoconazole …
    VK Patil, UB Wagh, RP Phalak, JD Bhirud, HP Narkhede
    Analytical Methods 14 (9), 907-920 , 2022
    2022
    Citations: 3
  • A validated eco-friendly, operation-safe, and cost-effective RP-HPLC method for the determination of dodine in their pesticide dosage forms using ethanol: water as mobile phase
    V Patil, D Dalal, K Phatangare, S Bagul, H Narkhede
    International Journal of Environmental Analytical Chemistry 104 (18), 6358-6369 , 2024
    2024
    Citations: 2
  • A simple and rapid reverse-phase high-performance liquid chromatographic method for the determination of Propineb and Tricyclazole pesticides from the wettable powder formulation
    VK Patil, JG Chandorkar, DT Seshadri, JG Patil, NH Petha, TS Bhagat, ...
    Journal of the Iranian Chemical Society 20 (10), 2587-2594 , 2023
    2023
    Citations: 2
  • An Exploration of ChCl/Glycerol-Based Deep Eutectic Solvent as a Sustainable Reaction Medium for the Synthesis of Biologically Important Aminopyrazole and Aminopyrazolone Compounds
    JD Bhirud, GR Gupta, HP Narkhede
    Current Bioactive Compounds 18 (9), 50-60 , 2022
    2022
    Citations: 2
  • Synthesis and biological activity of 7-(2-(1H-1, 2, 4-triazol-1-yl) ethoxy)-4-(styryl/4-substituted styryl)-2H-chromen-2-one
    JD Bhirud, YB More, PD Baviskar, HP Narkhede
    Indian J. Chem. B 60, 1097-1102 , 2021
    2021
    Citations: 2
  • Synthesis of 4-(2-(substituted phenyl) diazenyl)-1-phenylpyrazolidine-3, 5-dione catalyzed by L-proline and their biological activity
    JD Bhiruda, PP Mahulikarb, HP Narkhede
    Indian Journal of Chemistry 57, 1208-1212 , 2018
    2018
    Citations: 2
  • Solid supported synthesis of bio-active dimeric alkylene and diketoalkylene 9H-carbazole compounds via greener methodology
    HP Narkhede
    International Journal 12, 551-556 , 2014
    2014
    Citations: 2
  • Synthesis of new dimeric carvacrol compounds.
    UB More, HP Narkhede, PP Mahulikar
    Organic Communications 1 (4) , 2008
    2008
    Citations: 2
  • An Expeditious and Facile Synthesis of Isoxazole Derivatives in Deep Eutectic Solvent
    JD Bhirud, HP Narkhede
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 30 (3), 421-424 , 2020
    2020
    Citations: 1
  • Efficient synthesis of azoxystrobin and its key intermediate using a newer DABCO-based catalyst
    ND Dhande, TT Pansare, UV Baviskar, HP Narkhede
    European Journal of Chemistry 17 (1), 19-25 , 2026
    2026
  • Antibacterial activity of copper nanoparticles
    YB More, HP Narkhede
    BIOINFOLET-A Quarterly Journal of Life Sciences 17 (1b), 144-144 , 2020
    2020