Recent Advancement in the Development of Benzothiazole as Anticancer Agents Anshu Rupesh Dudhe, Rupesh Dudhe, Mohammad Hashim Mansoori, Chandrayani N. Rokde Current Bioactive Compounds, 2026 Benzothiazole is an aromatic heterocyclic compound with the chemical formula C<sub>7</sub>H<sub>5</sub>NS. It is a colorless, slightly viscous liquid and has various applications in dyes, drugs, food additives, etc. Benzothiazole derivatives represent a diverse class of compounds with significant biological and pharmacological activities. The benzothiazole scaffold, characterized by its aromatic thiazole ring fused to a benzene ring, offers versatility in functionalization, enabling the development of compounds with tailored properties. Benzothiazole derivatives have shown potential in pharmaceutical applications, including antimicrobial, antifungal, and anticancer agents. Some compounds are also being explored for their potential use in treating neurodegenerative diseases. Traditional methods for benzothiazole synthesis typically involve the cyclization of 2- aminothiophenol with carboxylic acids, aldehydes, or nitriles under acidic or oxidative conditions. These classical approaches have been extensively studied and optimized, allowing for the efficient production of benzothiazole derivatives with high yields. Recent advancements in green chemistry have led to the development of more sustainable and environmentally friendly synthesis methods. For example, microwave-assisted synthesis and solvent-free reactions have gained attention for their ability to reduce reaction times, lower energy consumption, and minimize the use of hazardous solvents. Its derivatives continue to be the focus of extensive research, promising further innovations and applications in the future. This review highlights key synthetic strategies employed for their preparation and explores their anticancer activity. The abstract concludes with a discussion on future perspectives and challenges in the further exploration and development of benzothiazole derivatives for novel therapeutic applications. This abstract provides an overview of their chemical structure, synthesis methods, and diverse applications in medicinal chemistry.
Future Trends of Social Media in Healthcare Promotion Manisha Kawadkar, Deepika Devnani, Rupesh Dudhe, Anshu R. Dudhe, Omji Porwal Intelligent Data Analytics in Media Communication to Improve Public Health Care, 2025 One of the trickiest parts of health promotion programs is coming up with ways to change people’s habits for the better. There is hope that social media, as an innovative and widely used platform for communication and education, might influence people to adopt healthier lifestyle habits. Although there is an upsurge in studies investigating the potential of social media for health promotion, it is important to evaluate the strategies used to impact health behavior change rather than only increase awareness. Because of its ability to remove real-world barriers to healthcare, social media is finding more and more applications in public health education. To optimize consumer health outcomes in both online and offline settings, health education professionals need to become more skilled in computermediated environments, which are becoming more important in health promotion due to the increasing reliance on Internet-based programming. Health education professionals are always weighing the pros and cons of social media use in the field, so it is important for them to have a better understanding of both sides of the coin.
Challenges to Social Media for Improving Health Care Deepika Devnani, Manisha Kawadkar, Rupesh Dudhe, Anshu R. Dudhe, Omji Porwal Intelligent Data Analytics in Media Communication to Improve Public Health Care, 2025 The use of social media is quickly becoming an integral part of healthcare data management strategies. Nevertheless, there has been little attempt to review previous work in this area, despite the massive growth of research in this area. Health advice, social support, managing or living with chronic conditions, and making day-to-day health decisions may all be greatly improved with the use of social media technologies that connect patients, caregivers, and health practitioners. While these systems have been widely used, they do not always meet the expectations of designers and users when it comes to accomplishing their goals. Concerns like as accessibility, personalization in social contexts, dependability of policy information, and balancing sharing and privacy are examples of such issues. Applying Ackerman’s CSCW paradigm to this work may help those who study, create, deploy, and use social media platforms to promote health goals. The study’s goal was to shed light on the pros and cons of using social media for health information management. In particular, we need to recognize that technological systems can’t solve all of our social problems on their own.
Molecular Docking: An Essential Step in Computer-Aided Drug Design Lata Potey, Suchita Waghmare, Anshu Chaudhary Dudhe, Rupesh Dudhe, Prafulla Sabale Drug Delivery Systems Using Quantum Computing, 2024 Medicinal chemistry is concerned with the discovery, creation, interpretation of physiologically active chemical mode of action, and identification at the molecular level. Medicinal plants have historically proven their value as a source of molecules with therapeutic potential, and nowadays still represent an important pool for the identification of novel drug leads. Many potent compounds found in plants can be employed for the design, synthesis, and semi-synthesis of novel medications for the treatment of diseases. Finding and creating new medications are a laborious process that entails hunting for promising hits, turning those hits into leads, and then finally, validating those leads into therapeutic candidates in clinical trials. Drug discovery is a process that involves the identification of candidates, synthesis, characterization, validation, optimization, screening, and assays for therapeutic efficacy. Once a compound has shown its significance in these investigations, it will initiate the process of drug development earlier to clinical trials. The new drug development process must continue through several stages to make medicine that is safe, effective, and meets all regulatory requirements. Introducing a new drug to the market is a complex and time-consuming process that can cost pharmaceutical companies an average of $ 1 trillion by 2030 and 10 years of research and development. Against this complex background, this chapter examines the role of the computer-aided drug design potential of the remarkable developments in the basic biomedical sciences for global health care.
Wide-ranging Study on Synthesis and Biological Evaluation of 1, 2, 3-triazole Anshu Dudhe, Rupesh Dudhe, Renuka Mahajan, Neha Pathak, Vaibhav Uplanchiwar, Mohammad Hashim Mansoori Current Bioactive Compounds, 2024 1, 2, 3-Traizole is five-membered heterocyclic compounds having three nitrogen at 1, 2 and 3 positions. 1, 2, 3-Triazoles are important five-membered heterocyclic scaffolds due to their widespread biological activities. 1, 2, 3-Triazole derivative can be readily obtained in good to excellent yields through click chemistry, 1, 3-dipolar cycloaddition, Metal Catalysed azide-alyne cycloaddition method. 1, 2, 3-Triazoles showed various biological activities, such as antiinflammatory, anticonvulsant, antineoplastic, antimicrobial, analgesic, antimalarial, antiviral, antiproliferative, and anticancer activities. The objective of this review is to synthesize pharmacological activity of 1,2,3-triazole derivatives documented in recent literature.
Development and validation of RP-HPLC method for estimation of Cefotaxime sodium in bulk and formulation Esra Tariq Anwer, O. Porwal, R. Dudhe Research Journal of Pharmacy and Technology, 2022 To develop a novel, accurate, precise and linear reverse phase high performance liquid chromatographic (RP-HPLC) methods for quantitative determination of cefotaxime sodium (CFT) in bulk drug and CFT loaded nanoparticles. Different analytical performance parameters such as linearity, precision, accuracy, specificity, limit of detection (LOD) and limit of quantification (LOQ) were determined according to International Conference on Harmonization ICH Q2B guidelines. The RP-HPLC method was developed by the isocratic technique on a reversed-phase Zorbax C18 (250 × 4.6 mm, 5µm) column with mobile phase consisting of phosphate buffer (pH7.4): acetonitrile (80:20v/v) at flow rate of 1.2 ml/min. Detection was carried out using a UV detector at 254nm. The retention time for CFT was 6.580+0.5min. The standard curve was linear over the concentration range of 10-50μg/ml with r2 close to one (0.999). The limit of detection (LOD) and limit of quantitation (LOQ) obtained for CET were 0.100μg/ml and 0.314μg/ml respectively. The developed and validated method was successfully applied for the quantitative analysis of nanoparticle. The high recovery and low relative standard deviation confirm the suitability of the proposed method for determining the assay and in vitro dissolution of a marketed formulation.
Significance of Inorganic Nitrate Supplement in Cardiovascular Health Rupesh Dudhe, Anshu C. Dudhe, Shravan D. Raut Cardiovascular and Hematological Agents in Medicinal Chemistry, 2022 Background & Objectives: Nitric Oxide (NO) is frequently produced by the enzyme nitric oxide synthase (NOS) and is crucial for the control and effectiveness of the cardiovascular system. However, there is a substantial reduction in NOS activity with aging that can lead to the development of hypertension and other cardiovascular obstacles. Fortunately, NO can also be produced by sequential reduction of inorganic nitrates supplementation. This proves that NO from inorganic nitrate supplements can compensate for inadequate NOS activity, thus providing cardio protective benefits. Discussion: This review focuses on the general information about nitrous oxide, its types and mechanism of action and the fact that overview of inadequate NOS activity for cardio protective benefits was often studied for cardiovascular treatments. Conclusion: We concluded that the natural plant NO is essential for cardiovascular activity to target site with desired concentration. Moreover, the researchers focused on evidence that suggested that nitrate supplementation could help regulate blood pressure, limit progression of atherosclerosis, and improve myocardial contractility in both healthy individuals and those with cardiovascular diseases.
An Overview of Synthesis and Biological Activity of Dihydropyrimidine Derivatives Anshu Chaudhary Dudhe, Rupesh Dudhe, Omji Porwal, Gayatri katole Mini Reviews in Medicinal Chemistry, 2022 Dihydropyrimidine derivatives are the most important scaffolds due to structural similarities with natural products; it is a heterocyclic compound. The chemistry of Dihydropyrimidine is a growing field. Various reaction schemes for the preparation of Dihydropyrimidines produce different biological effects and offer vast scope in the field of medicinal chemistry. This article's goal is to analyze the work that reported the recent chemistry and pharmacological activities of dihydropyrimidine derivatives.
The Concept of Repurposing in COVID-19 Infection Lata Potey, Anshu Chaudhary Dudhe, Dhanashri Tumme, Rupesh Dudhea, Prafulla Sable Coronaviruses, 2022 The strategy of drug repurposing has been proved successful in response to the current coronavirus pandemic, with remdesivir becoming the first drug of choice, an antiviral drug approved for the treatment of COVID-19. In parallel to this, several drugs, such as antimalarial, corticosteroids, and antibiotics, like azithromycin, are used to treat the severe condition of hospitalized COVID-19 patients, while clinical testing of additional therapeutic drugs, including vaccines, is going on. It is reasonably expected that this review article will deliver optimized and specific curative tools that will increase the attentiveness of health systems to the probable outlook of epidemics in the future. This review focuses on the application of repurposed drugs by studying their structure, pharmacokinetic study, different mechanisms of action, and Covid-19 guidelines, which can potentially influence SARS-CoV-2. For most of the drugs, direct clinical evidence regarding their effectiveness in the treatment of COVID-19 is missing. Future clinical trial studies may conclude that one of these can be more potential to inhibit the progression of COVID-19.
Discovery of substituted hydroxylphenyl pyrimidine-2(1H) thione as a new series of antioxidant using AAU and AAI method Walailak Journal of Science and Technology, 2015
Antioxidant and anti-inflammatory activity of ethanolic extract of Parthenium hysterophorus Linn Asian Journal of Pharmaceutical and Clinical Research, 2012
Recent advancements in the synthesis and pharmacological evaluation of substituted 1, 3, 4-thiadiazole derivatives International Journal of Pharmtech Research, 2010
Synthesis and biological evaluation of N3-(4-Substituted phenyl)-N5-Phenyl-4H-1,2,4-Triazole-3,5-diamine derivatives Oriental Journal of Chemistry, 2009
