Rômulo Farias Carneiro

Scopus Publications

Rational Engineering of a Floral Nectar Peptide Generates Enhanced Antimicrobial Analogs with Different Modes of Action
Dário R. A. L. Mourão, João M. Matos‐Neto, Queilane L. S. Chaves, Mariana F. Oliveira, Viviane O. Silva, et al.
Chemmedchem, 2026
Antibiotic resistance is a critical challenge for global public health, stimulating the search for effective therapeutic alternatives. In this context, antimicrobial peptides (AMPs) stand out as promising candidates due to their structural diversity and multiple mechanisms of action. In this study, AMPs present in the floral nectar of Nicotiana sp. were evaluated for antibacterial activity against Staphylococcus epidermidis , S. aureus , Klebsiella pneumoniae , and Pseudomonas aeruginosa . Nicotianin‐I (NI) was identified as the most active natural peptide, although with limited efficacy. Therefore, it was selected as a model for rational engineering. From its sequence, two bioinspired analogs, NI‐A and NI‐B, were developed and showed significantly increased antibacterial activity in a strain‐dependent manner, as demonstrated by planktonic growth inhibition and cell viability assays. Mechanistic analyses indicated that NI‐A acts predominantly by destabilizing bacterial membranes, while NI‐B induces oxidative stress. Structural characterization revealed improved amphipathicity and environment‐dependent folding behavior. Hemolysis assays demonstrated that only NI‐B maintains low toxicity against human erythrocytes. Overall, these results highlight rational peptide engineering as a powerful strategy to transform low‐activity natural AMPs into optimized antimicrobial candidates with defined mechanisms and therapeutic potential.
Sponge Galectins: Structure, Evolution, and Function
Andressa Rocha de Oliveira Sousa, Jessica de Assis Duarte Ferreira da Ponte, Alexandre Holanda Sampaio, Celso Shiniti Nagano, Rômulo Farias Carneiro
ACS Omega, 2026
Biophysical Characterization of a Carotenoprotein from Marine Sponge Tedania ignis Reveals Pigment-Dependent Stability and Antibiotic Interactions
Philippe Lima Duarte, Paulo Anderson Paiva Martins, Jéssica de Assis Duarte, Manoel Ferreira da Costa Filho, Ellen Araújo Malveira, et al.
Marine Drugs, 2026
Carotenoproteins from marine sponges represent an underexplored class of pigment–protein complexes with distinctive structural and functional properties. Here, we report the isolation and biophysical characterization of a blue carotenoprotein from the sponge Tedania ignis, termed Ti-CP. The protein was purified and shown to consist of two closely related isoforms with molecular masses of approximately 27–29 kDa. Reverse-phase chromatography enabled separation of the apoprotein (ApoTi-CP) and its associated carotenoids, which were identified as oxygenated carotenoids consistent with astaxanthin and mytiloxanthin. Circular dichroism analysis revealed that both Ti-CP and ApoTi-CP are dominated by β-sheet secondary structure and display highly similar conformational profiles. In contrast, dynamic light scattering demonstrated that carotenoid binding is critical for protein stability, as the native form exhibited a compact and monodisperse organization, whereas ApoTi-CP showed pronounced aggregation. Isothermal titration calorimetry revealed that Ti-CP, but not ApoTi-CP, interacts with tetracycline, oxacillin, and streptomycin, indicating that pigment-mediated stabilization modulates ligand binding. Both Ti-CP and ApoTi-CP reduced bacterial viability and biofilm formation in a strain-dependent manner and enhanced antibiotic activity, including synergistic effects against resistant bacteria. Together, these results provide a comprehensive description of a previously uncharacterized sponge carotenoprotein and highlight the dual role of carotenoids in structural stabilization and antimicrobial modulation, reinforcing the biotechnological relevance of marine pigment–protein complexes.
Antihyperglycemic and antioxidant potential of a lectin from Alsidium triquetrum in streptozotocin-induced diabetic rats
Mayron Alves de Vasconcelos, Mayara Freire de Alencar Alves, Luiz Gonzaga do Nascimento Neto, Francisco Vassiliepe Sousa Arruda, Maria do Perpétuo Socorro Saldanha da Cunha, et al.
Natural Product Research, 2026
This study aimed to evaluate the antihyperglycemic and antioxidant activities of the lectin isolated from Alsidium triquetrum (BTL). Diabetes was induced in Wistar rats through low-dose streptozotocin injections. Following the confirmation of hyperglycaemia, the animals were treated with 150 mM NaCl, glibenclamide, or BTL at 600 or 900 mg/kg. The efficacy of BTL treatment was assessed by measuring serum glucose, total cholesterol, triglycerides, glutathione peroxidase, catalase, and superoxide dismutase levels on days 7, 14, and 21 post-induction. On day 21, pancreas and liver tissues were excised for histopathological analysis. BTL significantly reduced serum glucose, total cholesterol, and triglyceride levels while increasing all antioxidant enzyme levels. Moreover, the histopathological analysis suggests that BTL exerts a protective effect against diabetes-induced damage in hepatic and pancreatic tissues, indicating its potential as a therapeutic agent in managing diabetes.
Structural characterization and bacterial agglutination of a new OAAH-type lectin from the marine red alga Amansia multifida J.V. Lamouroux
Renata Pinheiro Chaves, Gloria Steffanne Damasio da Silva, Suzete Roberta da Silva, Vinícius Paulino Pinto Menezes, Andressa Rocha de Oliveira Sousa, et al.
Journal of Applied Phycology, 2026
Lectins are carbohydrate-binding proteins involved in diverse biological processes and with increasing relevance in biotechnological applications. In this study we report the structural characterization of a lectin from the marine red alga Amansia multifida (AML). Mass spectrometry analysis revealed two major isoforms with molecular masses of 28,388 Da and 28,661 Da. The primary structure of a lectin with a molecular weight of 28,661 Da was determined by combination of N-terminal Edman degradation, tandem mass spectrometry, and RACE-PCR, revealing four tandemly repeated domains and high sequence identity with members of the OAAH ( Oscillatoria agardhii agglutinin homologous) lectin family. Notably, A. multifida belongs to the order Ceramiales, suggesting a broader taxonomic distribution for this lectin family, previously restricted to species from the order Gigartinales. Secondary and tertiary structure analyses suggested a predominantly β-sheet conformation and a β-barrel fold, characteristic of OAAH lectins. Molecular docking showed conserved recognition of mannosylated glycans, supported by the presence of the QWGGREGPI motif in all carbohydrate recognition domains. Although AML did not exhibit direct antibacterial or antibiofilm activity, it was able to agglutinate Escherichia coli and Staphylococcus aureus strains, indicating potential interactions with mannoside-rich surface glycans. These findings enhance our understanding of marine lectin diversity and highlight AML as a new lectin of OAAH family.
Targeting Non-albicans Candida Strains and Phytopathogenic Fusarium Species with Chitooligosaccharides: Insights into the Antifungal Mechanism
Mayara I. G. Azevedo, Nadine M. S. Araujo, Filipe A. Vieira, Milena B. Cherene, Bruno R. S. Queiroz, et al.
ACS Omega, 2025
DVL, a Lectin from Dioclea violacea Seeds, Disturbs the Proteomic Profile of Candida krusei, Leading to Cell Death
Romério R. S. Silva, Rayara J. P. Carvalho, Maria H. C. Santos, Ana L. E. Santos, Rômulo F. Carneiro, et al.
Antibiotics, 2025
Background/Objectives Plant lectins have emerged as potential antifungal molecules, where the carbohydrate recognition domain (CRD) is possibly the main mode of action of these proteins. Previously, we saw that the lectin extracted from the seeds of Dioclea violacea (DVL) has anti-candida activity against Candida krusei cells by acting to inhibit ergosterol biosynthesis, cell wall deformation, and deregulation of the redox system. Methods We have now confirmed this anti-candida activity by proteomic analysis, with the expression of proteins that show us how C. krusei cells respond to this treatment. Results A total of 395 proteins were identified: 142 proteins exclusively found in untreated C. krusei cells and 245 proteins exclusive to DVL-treated cells. Eight proteins were detected in both conditions. Six displayed positive accumulation (fold change > 1.5), one exhibited negative accumulation (fold change < 0.5). We observed the expression of proteins related to cell wall remodeling; alteration of energy metabolism, suggesting a metabolic adaptation to stress; oxidative stress was responded to through the expression of proteins with antioxidant action, in addition to identifying multidrug transport proteins that are often involved in the process of antifungal resistance and sterol transport to the membrane. Conclusions Our results show the complexity of adaptive responses of C. krusei cells to treatment with DVL, elucidating new mechanisms of resistance and paving the way for the development of more effective and innovative antifungal therapies.
Lectins of algal origin: 25 years of progress in structural insights and biotechnological applications
Manoel Ferreira da Costa Filho, Ellen Maria Lima Gonçalves, Renata Pinheiro Chaves, Rômulo Farias Carneiro, Alexandre Holanda Sampaio, et al.
Journal of Applied Phycology, 2025
Proteomic Analysis Revealed that DVL, a Lectin Purified from Dioclea violacea Seeds, Induced a Change in the Protein Profile of Candida albicans
Romério R. S. Silva, Maria H. C. Santos, Ana L. E. Santos, Cleverson D. T. Freitas, Rômulo F. Carneiro, et al.
ACS Omega, 2025
Afil, a Lectin from Aplysina fistularis, Exhibits Antibiofilm and Synergistic Antibacterial Activity Against Resistant Bacteria
Francisco Regivanio Nascimento Andrade, João Marcelo de Sousa Silva, Jéssica de Assis Duarte, Philippe Lima Duarte, Pedro Arthur Sousa Tabosa, et al.
Microorganisms, 2025
Lectins from marine sponges have emerged as promising candidates for antimicrobial strategies, particularly against biofilm-forming pathogens. In this study, we report the purification, biochemical characterization, and antibiofilm properties of a new lectin (AfiL) isolated from Aplysina fistularis. AfiL exhibited typical features of sponge lectins, including a β-sheet-rich secondary structure and a predominant oligomeric state in solution. Dynamic light scattering (DLS) analyses confirmed that AfiL predominantly exists as a well-defined oligomer at acidic and neutral pH. Sequence analysis revealed similarity to a putative collectin-like protein from sponge Desydea avara. AfiL selectively agglutinated Staphylococcus aureus strains, correlating with its preferential binding to lipoteichoic acid (LTA). The lectin demonstrated significant antibiofilm activity against S. aureus, S. epidermidis, and Escherichia coli strains, and exhibited synergistic or additive effects when combined with conventional antibiotics against a Methicillin-resistant S. aureus. Isothermal titration calorimetry (ITC) revealed a strong interaction between AfiL and porcine stomach mucin (Kd = 1.71 × 10−6 M), consistent with multivalent carbohydrate recognition. Overall, our findings highlight the potential of AfiL as a novel antibiofilm agent with species-specific modulatory effects on antibiotic activity and provide new insights into the functional versatility of sponge-derived lectins in microbial control strategies.
Nicotianin-I: A Tobacco Floral Nectar Peptide with Anticandidal Activity
João M. M. Neto, Tawanny K. B. Aguiar, Mariana F. Oliveira, Queilane L. S. G. Chaves, Dário R. A. L. Mourão, et al.
ACS Omega, 2025
A novel galectin with triple carbohydrate recognition domain in the parotoid secretion of Rhinella diptycha
Cássia Ferreira Rodrigues, Bruno Lopes de Sousa, João Hermínio Martins da Silva, Leonardo Abreu Andrade Amorim, Celso Shiniti Nagano, et al.
International Journal of Biological Macromolecules, 2025
Bioprospecting of Marine Organisms: Exploring Antibacterial Activities in Aqueous and Organic Extracts
Vinícius Paulino Pinto Menezes, Aldeni Moreira da Silva Filho, Aline Jeferson Costa, Elielton Nascimento, Ulisses Santos Pinheiro, et al.
Microorganisms, 2025
Structural insights and antimicrobial synergy of a proto-galectin from the marine sponge Aiolochroia crassa
Renato Cezar Farias Torres, Israel Ferreira Barbosa Júnior, Victoria Régia Pinto de Souza, Jéssica de Assis Duarte, Renata Pinheiro Chaves, et al.
Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology, 2025
Kinetics characterization of a low immunogenic recombinant L-asparaginase from Phaseolus vulgaris with cytotoxic activity against leukemia cells
José Gabriel da Silva Gomes, Larisse Cadeira Brandão, Daniel Pascoalino Pinheiro, Larissa Queiroz Pontes, Rômulo Farias Carneiro, et al.
International Journal of Biological Macromolecules, 2024
Glucose-Binding Dioclea bicolor Lectin (DBL): Purification, Characterization, Structural Analysis, and Antibacterial Properties
Willian F. Reis, Marcos E. S. Silva, Ana C. S. Gondim, Renato C. F. Torres, Rômulo F. Carneiro, et al.
Protein Journal, 2024
Toward Enhanced Antibiotic Efficacy: Exploring the Synergistic Potential of Marine-Derived Lectins Against Human Pathogenic Bacteria
RÔMULO F. CARNEIRO, PEDRO ARTHUR S. TABOSA, JOSÉ GABRIEL S. CÂNDIDO, VINÍCIUS PAULINO P. MENEZES, PEDRO ABILIO V. ROCHA JÚNIOR, et al.
Anais Da Academia Brasileira De Ciencias, 2024
Purification, Characterization and Evaluation of the Anticoagulant Effect of an Uncompetitive Trypsin Inhibitor obtained from Bauhinia pulchella (Benth) Seeds
Renato R. Roma, Lucas P. Dias, Ana L.E. Santos, Romério R.S. Silva, Maria H.C. Santos, et al.
Current Protein and Peptide Science, 2024
Structural characterization of a galectin from the marine sponge Aplysina lactuca (ALL) with synergistic effects when associated with antibiotics against bacteria
Jéssica de Assis Duarte, José Eduardo de Oliveira Neto, Renato Cézar Farias Torres, Andressa Rocha de Oliveira Sousa, Alexandre Lopes Andrade, et al.
Biochimie, 2023
Structural study and antimicrobial and wound healing effects of lectin from Solieria filiformis (Kützing) P.W.Gabrielson
Renata Pinheiro Chaves, Ana Kátia Barbosa dos Santos, Alexandre Lopes Andrade, Aryane de Azevedo Pinheiro, Juliana Meneses de Sena Silva, et al.
Biochimie, 2023
No Chance to Survive: Mo-CBP3-PepII Synthetic Peptide Acts on Cryptococcus neoformans by Multiple Mechanisms of Action
Tawanny K. B. Aguiar, Felipe P. Mesquita, Nilton A. S. Neto, Francisco Í. R. Gomes, Cleverson D. T. Freitas, et al.
Antibiotics, 2023
Purification, biochemical characterization of a lectin from marine sponge Ircinia strobilina and its effect on the inhibition of bacterial biofilms
ALEXANDRA S. DE ALMEIDA, DAYARA N.M. MENDONÇA, RÔMULO F. CARNEIRO, ULISSES PINHEIRO, ELIELTON FRANCISCO DO NASCIMENTO, et al.
Anais Da Academia Brasileira De Ciencias, 2023
United we stand, divided we fall: in-depth proteomic evaluation of the synergistic effect of Mo-CBP3-PepI and Ciprofloxacin against Staphylococcus aureus biofilms
Nilton A. S. Neto, Tawanny K. B. Aguiar, Rayara J. P. Costa, Felipe P. Mesquita, Lais L. B. de Oliveira, et al.
Biofouling, 2023
New lectin isolated from the tropical sponge Haliclona (Reniera) implexiformis (Hechtel, 1965) shows antibiofilm effect
FRANCISCO R.N. ANDRADE, PEDRO A.S. TABOSA, RENATO C.F. TORRES, RÔMULO F. CARNEIRO, MAYRON A. VASCONCELOS, et al.
Anais Da Academia Brasileira De Ciencias, 2023
A fibrinogen-related Lectin from Echinometra lucunter represents a new FReP family in Echinodermata phylum
Philippe Lima Duarte, Francisco Regivânio Nascimento Andrade, Andressa Rocha de Oliveira Sousa, Alexandre Lopes Andrade, Mayron Alves de Vasconcelos, et al.
Fish and Shellfish Immunology, 2022
New Insights into the Mechanism of Antibacterial Action of Synthetic Peptide Mo-CBP3-PepI against Klebsiella pneumoniae
Levi A. C. Branco, Pedro F. N. Souza, Nilton A. S. Neto, Tawanny K. B. Aguiar, Ayrles F. B. Silva, et al.
Antibiotics, 2022
Luffa operculata seed proteins: Identification by LC-ESI-MS/MS and biotechnological potential against Candida albicans and C. krusei
André L. Silva, Leandro P. Bezerra, Cleverson D.T. Freitas, Ayrles F.B. Silva, Felipe P. Mesquita, et al.
Analytical Biochemistry, 2022
Insights into the structure and mechanism of action of the anti-candidal lectin Mo-CBP2 and evaluation of its synergistic effect and antibiofilm activity
João Xavier da Silva Neto, Lucas Pinheiro Dias, Larissa Alves Lopes de Souza, Helen Paula Silva da Costa, Ilka Maria Vasconcelos, et al.
Process Biochemistry, 2022
JcTI-PepI, a synthetic peptide bioinspired in the trypsin inhibitor from Jatropha curcas, presents potent inhibitory activity against C. krusei, a neglected pathogen
Larissa A.L. Souza, Lucas P. Dias, Nadine M.S. Araújo, Rômulo F. Carneiro, Celso S. Nagano, et al.
Biochimie, 2022
Codium isthmocladum lectin 1 (CiL-1): Interaction with N-glycans explains antinociceptive and anti-inflammatory activities in adult zebrafish (Danio rerio)
Antônio Willame da Silva Alves, Bruno Lopes Sousa, Luiz Francisco Wemmenson Gonçalves Moura, Emanuela de Lima Rebouças, Marnielle Rodrigues Coutinho, et al.
International Journal of Biological Macromolecules, 2022
Structural characterization of a galectin isolated from the marine sponge Chondrilla caribensis with leishmanicidal potential
Andressa Rocha de Oliveira Sousa, Francisco Regivânio Nascimento Andrade, Renata Pinheiro Chaves, Bruno Lopes de Sousa, Dimas Batista de Lima, et al.
Biochimica Et Biophysica Acta General Subjects, 2021
Elucidation of the primary structure and molecular modeling of Parkia pendula lectin and in vitro evaluation of the leishmanicidal activity
Romulo F. Carneiro, Evelyn S. Aguiar, Valdenice F. Santos, Ana L.E. Santos, Maria H.C. Santos, et al.
Process Biochemistry, 2021
Secretory production in Escherichia coli of a GH46 chitosanase from Chromobacterium violaceum, suitable to generate antifungal chitooligosaccharides
Mayara I.G. Azevedo, Simone T. Oliveira, Christiana F.B. Silva, Rômulo F. Carneiro, Celso S. Nagano, et al.
International Journal of Biological Macromolecules, 2020
Structural and functional features of a class VI chitinase from cashew (Anacardium occidentale L.) with antifungal properties
Simone T. Oliveira, Mayara I.G. Azevedo, Rodrigo M.S. Cunha, Christiana F.B. Silva, Celli R. Muniz, et al.
Phytochemistry, 2020
New lectins from Codium isthmocladum Vickers show unique amino acid sequence and antibiofilm effect on pathogenic bacteria
Rômulo Farias Carneiro, Philippe Lima Duarte, Renata Pinheiro Chaves, Suzete Roberta da Silva, Ramon Rodrigues Feitosa, et al.
Journal of Applied Phycology, 2020
Antihyperglycemic and antioxidant activities of a lectin from the marine red algae, Bryothamnion seaforthii, in rats with streptozotocin-induced diabetes
Mayara Freire de Alencar Alves, Francisca Kalline de Almeida Barreto, Mayron Alves de Vasconcelos, Luiz Gonzaga do Nascimento Neto, Rômulo Farias Carneiro, et al.
International Journal of Biological Macromolecules, 2020
RcAlb-PepII, a synthetic small peptide bioinspired in the 2S albumin from the seed cake of Ricinus communis, is a potent antimicrobial agent against Klebsiella pneumoniae and Candida parapsilosis
Lucas P. Dias, Pedro F.N. Souza, Jose T.A. Oliveira, Ilka M. Vasconcelos, Nadine M.S. Araújo, et al.
Biochimica Et Biophysica Acta Biomembranes, 2020
ClCPI, a cysteine protease inhibitor purified from Cassia leiandra seeds has antifungal activity against Candida tropicalis by inducing disruption of the cell surface
Ivna R.S. Melo, Lucas P. Dias, Nadine M.S. Araújo, Ilka M. Vasconcelos, Thiago F. Martins, et al.
International Journal of Biological Macromolecules, 2019
Purification and biophysical characterization of a mannose/N-acetyl-D-glucosamine-specific lectin from Machaerium acutifolium and its effect on inhibition of orofacial pain via TRPV1 receptor
Ana L.E. Santos, Gerlânia O. Leite, Romulo F. Carneiro, Renato R. Roma, Valdenice F. Santos, et al.
Archives of Biochemistry and Biophysics, 2019
A new mucin-binding lectin from the marine sponge Aplysina fulva (AFL) exhibits antibiofilm effects
Rômulo Farias Carneiro, Jhonatas Teixeira Viana, Renato Cézar Farias Torres, Lídia Torquato da Silva, Alexandre Lopes Andrade, et al.
Archives of Biochemistry and Biophysics, 2019
Structural aspects and physiological implications of the hemoglobin of green iguana (Iguana iguana)
Claudener S. Teixeira, Mario E.S. Cabral, Rômulo F. Carneiro, Samuel V. Brito, Celso S. Nagano, et al.
International Journal of Biological Macromolecules, 2018
Cloning of cDNA sequences encoding cowpea (Vigna unguiculata) vicilins: Computational simulations suggest a binding mode of cowpea vicilins to chitin oligomers
Antônio J. Rocha, Bruno L. Sousa, Matheus S. Girão, Ito L. Barroso-Neto, José E. Monteiro-Júnior, et al.
International Journal of Biological Macromolecules, 2018
Meristiella echinocarpa lectin (MEL): a new member of the OAAH-lectin family
Renata Pinheiro Chaves, Suzete Roberta da Silva, João Pedro Freire Alves da Silva, Rômulo Farias Carneiro, Bruno Lopes de Sousa, et al.
Journal of Applied Phycology, 2018
Antibacterial activity of a new lectin isolated from the marine sponge Chondrilla caribensis
Dayara Normando Marques, Alexandra Sampaio de Almeida, Andressa Rocha de Oliveira Sousa, Rafael Pereira, Alexandre Lopes Andrade, et al.
International Journal of Biological Macromolecules, 2018
Structural characterization of two isolectins from the marine red alga Solieria filiformis (Kützing) P.W. Gabrielson and their anticancer effect on MCF-7 breast cancer cells
Renata Pinheiro Chaves, Suzete Roberta da Silva, Luiz Gonzaga Nascimento Neto, Romulo Farias Carneiro, André Luis Coelho da Silva, et al.
International Journal of Biological Macromolecules, 2018
Halilectin-3, a lectin from the marine sponge Haliclona caerulea, induces apoptosis and autophagy in human breast cancer MCF7 cells through caspase-9 pathway and LC3-II protein expression
Luiz G. do Nascimento-Neto, Maria G. Cabral, Romulo F. Carneiro, Zelia Silva, Francisco V.S. Arruda, et al.
Anti Cancer Agents in Medicinal Chemistry, 2018
Isolation, biochemical characterization and antibiofilm effect of a lectin from the marine sponge Aplysina lactuca
Rômulo Farias Carneiro, Paulo Henrique Pinheiro de Lima Jr., Renata Pinheiro Chaves, Rafael Pereira, Anna Luísa Pereira, et al.
International Journal of Biological Macromolecules, 2017
Purification, Biochemical Characterization, and Amino Acid Sequence of a Novel Type of Lectin from Aplysia dactylomela Eggs with Antibacterial/Antibiofilm Potential
Rômulo Farias Carneiro, Renato Cézar Farias Torres, Renata Pinheiro Chaves, Mayron Alves de Vasconcelos, Bruno Lopes de Sousa, et al.
Marine Biotechnology, 2017
Purification and primary structure of a novel mannose-specific lectin from Centrolobium microchaete Mart seeds
Mayron Alves de Vasconcelos, Ana Cecília Alves, Rômulo Farias Carneiro, Artur Hermano Sampaio Dias, Francisco William Viana Martins, et al.
International Journal of Biological Macromolecules, 2015
Hemagglutinating/Hemolytic activities in extracts of marine invertebrates from the Brazilian coast and isolation of two lectins from the marine sponge Cliona varians and the sea cucumber Holothuria grisea
Raniere M. Moura, Arthur A. Melo, Rômulo F. Carneiro, Cícera R.f. Rodrigues, Plínio Delatorre, et al.
Anais Da Academia Brasileira De Ciencias, 2015
Antioxidant, hemolytic, antimicrobial, and cytotoxic activities of the tropical Atlantic marine zoanthid Palythoa caribaeorum
DANIEL B. ALENCAR, ARTHUR A. MELO, GISELLE C. SILVA, REBECA L. LIMA, KELMA M.S. PIRES-CAVALCANTE, et al.
Anais Da Academia Brasileira De Ciencias, 2015
L-rhamnose-binding lectin from eggs of the Echinometra lucunter: Amino acid sequence and molecular modeling
Rômulo Farias Carneiro, Claudener Souza Teixeira, Arthur Alves de Melo, Alexandra Sampaio de Almeida, Benildo Sousa Cavada, et al.
International Journal of Biological Macromolecules, 2015
A chromophore-containing agglutinin from Haliclona manglaris: Purification and biochemical characterization
Rômulo Farias Carneiro, Alexandra Sampaio de Almeida, Arthur Alves de Melo, Daniel Barroso de Alencar, Oscarina Viana de Sousa, et al.
International Journal of Biological Macromolecules, 2015
HGA-2, a novel galactoside-binding lectin from the sea cucumber holothuria grisea binds to bacterial cells
Arthur Alves de Melo, Rômulo Farias Carneiro, Winnie de Melo Silva, Raniere da Mata Moura, Giselle Cristina Silva, et al.
International Journal of Biological Macromolecules, 2014
Purification, partial characterization, and CNBr-Sepharose immobilization of a vasorelaxant glucose/mannose lectin from Canavalia virosa seeds
Vinicius J. S. Osterne, Mayara Q. Santiago, Vanir R. Pinto-Junior, João B. Cajazeiras, Jorge L. A. Correia, et al.
Applied Biochemistry and Biotechnology, 2014
Holothuria grisea agglutinin (HGA): The first invertebrate lectin with anti-inflammatory effects
Raniere da M. Moura, Karoline S. Aragão, Arthur A. de Melo, Rômulo F. Carneiro, César B. H. Osório, et al.
Fundamental and Clinical Pharmacology, 2013
Toxicity and binding profile of lectins from the genus canavalia on brine shrimp
Francisco Vassiliepe Sousa Arruda, Arthur Alves Melo, Mayron Alves Vasconcelos, Romulo Farias Carneiro, Ito Liberato Barroso-Neto, et al.
Biomed Research International, 2013
H-3, a new lectin from the marine sponge Haliclona caerulea: Purification and mass spectrometric characterization
Rômulo Farias Carneiro, Arthur Alves de Melo, Alexandra Sampaio de Almeida, Raniere da Mata Moura, Renata Pinheiro Chaves, et al.
International Journal of Biochemistry and Cell Biology, 2013
Halilectin 1 (H-1) and Halilectin 2 (H-2): Two new lectins isolated from the marine sponge Haliclona caerulea
Rômulo Farias Carneiro, Arthur Alves de Melo, Fernando Edson Pessoa do Nascimento, Clareane Avelino Simplicio, Kyria Santiago do Nascimento, et al.
Journal of Molecular Recognition, 2013
Characterization of isoforms of the lectin isolated from the red algae Bryothamnion seaforthii and its pro-healing effect
Luiz Gonzaga do Nascimento-Neto, Romulo Farias Carneiro, Suzete Roberta Da Silva, Bruno Rocha Da Silva, Francisco Vassiliepe Sousa Arruda, et al.
Marine Drugs, 2012

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