Dr. Bikash Ranjan Jena, M.Pharm., Ph.D

@cutm.irins.org

ASSOCIATE PROFESSOR IN PHARMACEUTICAL ANALYSIS RESEARCH DIVISION
Centurion University of Technology and Management, Bhubaneswar, Odisha, INDIA

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https://researchid.co/bikysims2020

Introduction: Dr. Bikash R Jena rurrently working at the Department of Pharmaceutical Analysis & Research Division at Centurion University (UGC, NAAC A+ accredited multi-sector skill university), Bhubaneswar Campus, Odisha, India. He has earned his Ph.D in Pharmaceutical Analysis at KL Deemed to be University (KLEF), UGC, NAAC A++ accredited, NIRF Rank 22, Category 1 University, Vadeswaram, Vijayawada, A.P., India.
Currently pursuing ADDRA from Jamia Hamdard, Deemed to be University, New Delhi (A Govt. Aided Deemed University, NIRF 1st 2025, UGC, NAAC A+ accredited), India.
So far I have 14+ years of academic & research experience in pharmaceutical analysis, chemometrics (AQbD), and bioanalytical development. I have published more than 88+ papers (research/review), Edited 5 international textbooks. Published 3 books as editor/co-editor & published 45+ book chapters in UGC-recognized, peer-reviewed impact journals (indexed in Scopus/Web of Sci/SCIE/PubMed) of reputed publishers

EDUCATION

Ph.D Awarded, at KL Deemed to be University, (UGC, NAAC A++, NIRF 22, Category 1 University), Vijayawada, A.P, India, Having 14 Yrs of academic and research experience. Published more than 50+ research Publications
Working as a Ph.D. research scholar and actively involved in Analytical Development. Assay, RS, Method Development, Method Validations, stability studies of novel compounds, using some sophisticated analytical instruments.
Persuing ADDRA at renowned Jamia Hamdard, Deemed to be University, New Delhi (A Govt. Aided Deemed University, NIRF 40, UGC, NAAC A+ accredited), India.

RESEARCH INTERESTS

Biotechnology, Chemistry, Medical Microbiology, Oncology, Statistics

Additional Specialties: I am very much interested for scientific writing, DoE avenue by using AQBD approach, Medical Writing, Publishing scientific manuscripts related to pharmaceutical (Analytical Research) fields with high indexing national and international journals.

58

Scopus Publications

469

Scholar Citations

12

Scholar h-index

13

Scholar i10-index

Scopus Publications

Physiologically Based Pharmacokinetic Modeling of Regorafenib Monohydrate-Loaded PEGylated PLGA Nanoparticles Employing GastroPlus™ Software
Dhananjay Panigrahi, Surya Kanta Swain, Bikash Ranjan Jena, Pratap Kumar Sahu
International Journal of Advancement in Life Sciences Research, 2026
Nanoparticles (NPs) have transformed drug delivery by altering the pharmacokinetics of small-molecule therapeutics by dramatically enhancing solubility, bioavailability and tumour specificity. By leveraging the enhanced permeability and retention EPR effect characteristics of tumour vasculature, nanoparticles exhibit preferential localisation within neoplastic tissues, enabling deep intratumoral penetration and the targeted delivery of therapeutic agents with high spatial precision. When wrapped in hydrophilic polymers like polyethylene glycol (PEG), these smart carriers evade immune detection, extending systemic circulation and amplifying drug accumulation at the disease site. Yet the very properties that make NPs so effective, such as their tunable size, shape, surface charge, and chemistry, also render their in vivo behaviour highly complex and difficult to predict from traditional in vitro assays. To bridge this gap, advanced modelling methodologiessuch as physiologically based pharmacokinetic modelling offer robust avenues for predicting the outcome, efficacy, and safety of these nanoengineered therapies. In these research findings, a robust rabbit physiologically based pharmacokinetic model or toxicokinetic model.
Quality by Design Optimization of Telmisartan-loaded Self-nanoemulsifying Drug Delivery Systems
Rajib Lochan Maharana, Suryakanta Swain, Santosh Kumar Mahapatra, Bikash Ranjan Jena
Current Nanomedicine, 2026
Aim: This study aimed to develop a QbD-based SNEDDS for Telmisartan to enhance its biopharmaceutical performance. Background: Quality by Design (QbD) was incorporated by selecting the Critical Process Pa-rameters (CPPs) as influential variables upon the desired responses. Using Design of Experiments (DoE) software, oil, and S/CoS were tested for pre-isotropic compatibility and formulation im-provement. A heating-cooling cycle and phase separation were used to determine the formula-tions' dispersibility, self-emulsifying time, mean globule size, and stability. Objective: Using Design of Experiments (DoE) software, oil (Capmul MCM C-10) and surfactant (Labrasol)/co-surfactant (Tween-20, and PEG-600) (S/CoS) ratios were optimized for pre-isotropic compatibility and formulation improvement. Methods: Aerosil-200, Sylysia-350, 550, and 730 were used as porous carriers, and Neusilin US2 as an adsorbing agent resulted in free-flowing granules of self-nano emulsifying drug delivery systems. The SNEDDS was further formulated into tablets using a direct compression technique with enhanced disintegration properties. Results: The prepared SNEDDS tablets exhibited a 71% increase in drug dissolution as compared to the pure drug and marketed formulation after the in vitro dissolution studies. Conclusion: This QbD approach offers a promising strategy for developing SNEDDS formula-tions for poorly soluble drugs like Telmisartan.
Topical nanoparticles for the treatment of skin cancer: Present concerns and challenges
Pritipragatika Nayak, Surya Kanta Swain, Itishree Jogamaya Das, Sushree Sambita Swain, Bikash Ranjan Jena, Himansu Bhusan Samal
Journal of Drug Delivery Science and Technology, 2025
Quality By Design Enabled Carvedilol Self-Nanoemulsifying Drug Delivery System: In Vitro and In Vivo Characterization for Improved Management of Hypertension
, Rajib Lochan Maharana, Surya Kanta Swain, , Santosh Kumar Mahapatra, , Debashish Ghose, , Bikash Ranjan Jena, and
Biomedical Sciences and Clinical Medicine, 2025
OBJECTIVE Due to poor absorption and substantial hepatic first-pass metabolism, carvedilol, a commonly used cardiovascular drug for hypertension and congestive heart failure, has a low and variable bioavailability. In order to enhance carvedilol solubility and prevent the first-pass impact, the current research work intends to produce SNEDDS of the drug using systematic DoE. This will ultimately increase its bioavailability. METHODS: By choosing the critical process parameters as factors that influenced the intended responses, quality by design was made possible. Oil and S/CoS were examined for pre-isotropic compatibility and formu-lation enhancement using Design of Experiment software. The cumulative percentage of drug release (QT30) in minutes, emulsification time (ET) in minutes, and emulsion globule size (nm) of the nano formulations were measured using a heating-cooling cycle and phase separation. To enhance carvedilol biopharmaceutical efficacy and oral bioavailability for the therapeutic management of cardiovascular disease. The carvedilol loaded self-nano emulsifying drug delivery system has been prepared by admixture method with selected oil, surfactant, and co-surfactant based on higher mean saturation solubility of drug. QbD approach presents an effective method to develop SNEDDS formulations of carvedilol with enhanced Using Design of experiments software, oil (Lauroglycol FCC), surfactant (Tween 20), and co-surfactant (Propylene glycol) were optimized for pre-isotropic compatibility and formulation development. RESULTS: The prepared SNEDDS exhibited non-Fickian mechanism of drug release, according to in vitro drug release kinetic data. The optimised formulation had uniform shape and nanosize with no physical incompatibilities between the selected excipients and the pure drug based on SEM, DSC and FT-IR. After six months of storage, remains stable, according to accelerated stability tests. CONCLUSIONS: In order to improve the therapeutic treatment of cardiovascular disease, the QbD approach presents an effective method to develop SNEDDS formulations of carvedilol with enhanced oral bioavailability and biopharmaceutical performance. KEYWORDS Pseudo-ternary phase diagram, Quality by design, SNEDDS, Hypertension, In vitro drug release, bioavailability, stability
Exploring application & recent advances of response surface methodology driven approach in drug design and nanotechnology
Bikash Ranjan Jena, Aradhana Panigrahi, Surya Kanta Swain, Himansu Bhusan Samal, Pratap Kumar Patra
Indian Journal of Microbiology Research, 2025
Exploring application & recent advances of response surface methodology driven approach in drug design and nanotechnology - IJMR- Print ISSN No: - 2394-546X Online ISSN No:- 2394-5478 Article DOI No:- 10.18231/j.ijmr.2025.022, Indian Journal of Microbiology Research-Indian J Microbiol Res
Biopolymers, hydrogel and their effect on drug development
Smart Ways of Biomaterial Designing Synthesis and Characterization Prospects of Enhanced Application from Labs to Clinics, 2025
Polymeric nanoparticles used in biosensors
Bikash Ranjan Jena, Rasmita Dash, Haragouri Mishra
Materials and Components of Biosensors in Healthcare Volume 2, 2025
Recent Developments and Applications of 3D-Printing Technology in Pharmaceutical Drug Delivery Systems: A New Research Direction and Future Trends
Surya Kanta Swain, Bikash Ranjan Jena, Rabinarayan Parhi
Current Pharmaceutical Design, 2025
The advent of 3D printing technology has emerged as a key technical revolution in recent years, enabling the development and production of innovative medication delivery methods in the pharmaceutical sector. The designs, concepts, techniques, key challenges, and potential benefits during 3D-printing technology are the key points discussed in this review. This technology primarily enables rapid, safe, and low-cost development of pharmaceutical formulations during the conventional and additive manufacturing processes. This phenomenon has wide-ranging implications in current as well as future medicinal developments. Advanced technologies such as Ink-Jet printing, drop-on-demand printing, Zip dose, Electrohydrodynamic Printing (Ejet) etc., are the current focus of the drug delivery systems for enhancing patient convenience and improving medication compliance. The current and future applications of various software, such as CAD software, and regulatory aspects in 3D and 4D printing technology are discussed briefly in this article. With respect to the prospective trajectory of 3D and 4D printing, it is probable that the newly developed methods will be predominantly utilized in pharmacies and hospitals to accommodate the unique requirements of individuals or niche groups. As a result, it is imperative that these technologies continue to advance and be improved in comparison to 2D printing in order to surmount the aforementioned regulatory and technical obstacles, render them applicable to a vast array of drug delivery systems, and increase their acceptability among patients of every generation.
Electrospun chitosan as a drug delivery system
Rabinarayan Parhi, Bikash Ranjan Jena, Bhisma Narayan Ratha, Suryakanta Swain
Electrospun Biomaterials for Tissue Engineering and Drug Delivery Applications, 2025
Self-emulsifying Drug Delivery Systems: Concept to Applications, Regulatory Issues, Recent Patents, Current Challenges and Future Directions
Rajib Lochan Maharana, Suryakanta Swain, Santosh Kumar Mahapatra, Bikash Ranjan Jena
Current Pharmaceutical Biotechnology, 2025
Self-emulsifying drug delivery systems (SEDDS) can increase the solubility and bioavailability of poorly soluble drugs. The inability of 35% to 40% of new pharmaceuticals to dissolve in water presents a serious challenge for the pharmaceutical industry. As a result, there must be dosage proportionality, considerable intra- and inter-subject variability, poor solubility, and limited lung bioavailability. As a result, it is critical that drugs intended for oral administration be highly soluble. This can be improved through a variety of means, including salt generation and the facilitation of solid and complicated dispersion. Surfactants, co-surfactants, and cosolvents may occasionally be found in SEDDS or isotropic blends. Lipophilic drugs, whose absorption is limited by their dissolution rate, have been used to demonstrate the effectiveness of various formulations and techniques. These particles can form microemulsions and suitable oilin- water emulsions with minimal agitation and dilution by the water phase as they pass through the gastrointestinal tract. This study summarises the numerous advances, biopharmaceutical components, variations, production techniques, characterisation approaches, limitations, and opportunities for SEDDS. With this context in mind, this review compiles a current account of biopharmaceutical advancements, such as the application of quality by design (QbD) methodologies to optimise drug formulations in different excipients with controllable ratios, the presence of regulatory roadblocks to progress, and the future consequences of SEDDS, encompassing composition, evaluation, diverse dosage forms, and innovative techniques for in-vitro converting liquid SEDDS to solid forms.
Emerging Applications of Medical Nanorobots in Health Care: Current Trends and Future Prospects
Surya Kanta Swain, Prafulla Kumar Sahu, Bikash Ranjan Jena, Biswajeet Acharya
Current Molecular Medicine, 2025
Nanomedicines for the management of atherosclerosis
Rabinarayan Parhi, Bikash Ranjan Jena, Aradhana Panigrahi, Suryakanta Swain
Nanobiomaterials and Nanomedicines for Metabolic Disorders, 2025
Computational Modelling of Pharmaceutical Die Filling Processes
Naseeb Basha Shaik, Roja Rani Budha, Bikash Rajan Jena, Rajasekhar Reddy Alavala, S. N. Koteswara Rao G.
Applications of Computational Tools in Drug Design and Development, 2025
Central composite design enabled formulation development, optimization, and characterization of bosutinib monohydrate loaded lipid nanoparticles: Cytotoxicity studies
Dhananjay Panigrahi, Surya Kanta Swain, Bikash Ranjan Jena, Prasanna Parida, Pratap Kumar Sahu
Journal of Applied Pharmaceutical Science, 2025
Liquisolid Technique for Solubility Enhancement of Poorly Soluble Drug - A Brief Review
Amaresh Prusty, Bikash Ranjan Jena, Vivek Barik, Piyali Khamkat, Bhakti Bhusan Barik
Current Drug Discovery Technologies, 2025
Biodegradable Polymer-based Nanoparticles: A Breakthrough in Oral Protein Drug Delivery
Prasanna Parida, Amiya Kumar Prusty, Bikash Ranjan Jena, Diptimayee Jena, Chinmaya Sahoo
Nanoscience and Nanotechnology Asia, 2025
Ionic gelation technique using biodegradable polymer for stabilized and sustained oral delivery of nano protein
Prasanna Parida, Amiya Kumar Prusty, Chinmaya Sahoo, Sujit Dash, Bikash Ranjan Jena, Kirtimaya Mishra
Advancement in Animal Handling and Generative AI for Pre Clinical Studies Animal Handling and Generative AI for Pre Clinical Studies, 2025
Envisioning Clinical Management of Breast Cancer: a Comprehensive Review
Shubhashree Das, Gurudutta Pattnaik, Sovan Pattanaik, Bikash Ranjan Jena, Bhabani Sankar Satapathy, Ayushi Pradhan
Current Drug Discovery Technologies, 2025
Overcoming hurdles in oral protein and peptide drug delivery: Strategies for future prospective
Prasanna Parida, Amiya Kumar Prusty, Rajat Kumar Prusty, Bikash Ranjan Jena, Debabrata Panda, Sanjoy Das
Advancement in Animal Handling and Generative AI for Pre Clinical Studies Animal Handling and Generative AI for Pre Clinical Studies, 2025
Development of in-situ ocular gel containing topiramate to understand its effect in intraocular pressure
Biswajeet Puhan, Aradhana Panigrahi, Guptanjali Sahu, Yashwant Giri, Bikash Ranjan Jena, Gurudutta Pattnaik
Advancement in Animal Handling and Generative AI for Pre Clinical Studies Animal Handling and Generative AI for Pre Clinical Studies, 2025
IONPs as strategic nanotools for cancer therapy: Concise updates on facile synthetic methods and stabilization
Jnanranjan Panda, Sagar Rout, Gurudutta Pattnaik, Himansu Bhusan Samal, Bikash Ranjan Jena, Bhabani Sankar Satapathy
Advancement in Animal Handling and Generative AI for Pre Clinical Studies Animal Handling and Generative AI for Pre Clinical Studies, 2025
COVID-19: Immergence, molecular mechanism of transmission and pathogenesis
Chinmaya Chidananda Behera, Sagar Mishra, Biswajit Mishra, Gurudutta Pattnaik, Bikash Ranjan Jena, Suman K Mekap
Advancement in Animal Handling and Generative AI for Pre Clinical Studies Animal Handling and Generative AI for Pre Clinical Studies, 2025
Autonomous Robots: A Disruptive Technology in the Health Sector
Creating Smart Healthcare with Blockchain and Advanced Digital Technology, 2025
Controlled Drug Delivery Systems: Advancements and Recent Patents
Suryakanta Swain, Sambamoorthy Unnam, Bikash Ranjan Jena, Nagadeepthi Naidu, Akhila Tejaswini Pilla, Haripriya Chunduru, Bindu Bhargavi Vennavalli
International Journal of Pharmaceutical Sciences and Nanotechnology, 2025
Development of sophisticated RP-HPLC approach for quantifying lornoxicam in API and pharmaceutical formulation
Biswa Mohan Sahoo, Chandan Kumar Brahma, Bikash Ranjan Jena, Kirtimaya Mishra, Debabrata Panda, Satya Narayan Tripathy, Dipika Rani Sahu
Advancement in Animal Handling and Generative AI for Pre Clinical Studies Animal Handling and Generative AI for Pre Clinical Studies, 2025
Inhalation Aerosol Based Targeted Drug Delivery to Upper Airways: Computational Fluid Dynamics (CFD) Approach
Bikash Rajan Jena, Soumyashree Tripathy, Surya Kanta Swain, Roja Rani Budha, Naseeb Basha Shaik, Rajasekhar Reddy Alavala, S. N. Koteswara Rao G., Amiya Prusty, Prasanna Parida
Applications of Computational Tools in Drug Design and Development, 2025
Synthesis of Ozone-Friendly Nanomaterials
Ayushi Pradhan, Bikash Ranjan Jena, Gurudutta Pattnaik, Ch. Niranjan Patra
Green Nanobiotechnology, 2024
Quality by design enabled formulation development of regorafenib monohydrate loaded PEGylated PLGA polymeric nanoparticles: Enhanced oral bioavailability and biopharmaceutical attributes
Dhananjay Panigrahi, Suryakanta Swain, Pratap Sahu, Debashish Ghose, Bikash Ranjan Jena
Nanomedicine Journal, 2024
Pandemic Corona Virus vs. Epidemic, and Endemic Virus Diseases: Present, Past, and Future Directions
Dr. Suryakanta Swain, Mr. Bikash Ranjan Jena, Mr. Debashis Ghose
Pandemic Corona Virus Vs Epidemic and Endemic Virus Diseases Present Past and Future Directions, 2024
World Health Organization and International Council for Harmonization guidelines for “Good Manufacturing Practices”
Rudra Narayan Sahoo, Niharika Pedamallu, Bikash Ranjan Jena
Physico Chemical Aspects of Dosage Forms and Biopharmaceutics Recent and Future Trends in Pharmaceutics Volume 2, 2024
Enzyme-Responsive Micro/Nano Drug Delivery
Bikash Ranjan Jena, Gurudutta Pattnaik, Himansu Bhusan Samal
Smart Micro and Nanomaterials for Drug Delivery, 2024
Current Advancements on Oral Protein and Peptide Drug Delivery Approaches to Bioavailability: Extensive Review on Patents
Prasanna Parida, Amiya Kumar Prusty, Saroj Kumar Patro, Bikash Ranjan Jena
Recent Advances in Drug Delivery and Formulation, 2024
Nanotechnology in Drug Delivery: An Overview of Developing the Blood Brain Barrier
Rasmita Dash, Subhankar Samanta, Bikash Ranjan Jena, Soumyaranjan Pradhan
Current Neurovascular Research, 2024
Genotoxic Impurities in Critical Analysis of Product Development: Recent Advancements, Patents, and Current Challenges
Suryakanta Swain, Bikash Ranjan Jena, Areti Anka Rao, Narender Malothu, Naga Jogayya Kothakota, Satya Narayan Tripathy
Current Pharmaceutical Biotechnology, 2024
The Prospective Applications of Arising Nanostructured Dielectric Materials in Storage of Energy: A Comprehensive Review
Suryakanta Swain, Himansu Bhusan Samal, Santosh Satpathy, Bikash Ranjan Jena, Gurudutta Pattnaik, Sheerin Bashar, Sonu Barad
Micro and Nanosystems, 2024
Advancements in Biomaterials for Envisioning Healing and Function Restoration in Modern Medicine – A Review
Suryakanta Swain, Ashirbaad Nanda, Rudra Narayan Sahu, Bikash Ranjan Jena, Rabisankar Dash, et al.
Journal of Angiotherapy, 2024
Biomedical applications of nanozymes
Emerging Environmental Applications of Nanozymes, 2023
Advancement and Applications of Platelet-inspired Nanoparticles: A Paradigm for Cancer Targeting
Suryakanta Swain, Debashish Ghose, Chinam Niranjan Patra, Bikash Ranjan Jena, Muddana Eswara Bhanoji Rao
Current Pharmaceutical Biotechnology, 2023
RP-UFLC based Bioanalytical Method Development, Optimization, and Validation for the Estimation of Isradipine in Rabbit Serum
Suryakanta Swain, Debashish Ghose, Chinam Niranjan Patra, Bikash Ranjan Jena
Current Analytical Chemistry, 2023
Quality by Design Driven Formulation Development, Optimization of Rosuvastatin Calcium Loaded Floating Microballoons: In Vitro and In Vivo Characterization
Suryakanta Swain, Sasikanth Kothamasu, Muddana Eswara Bhanoji Rao, Bikash Ranjan Jena
Drug Delivery Letters, 2023
Modern Advancements, Patents and Applications of Futuristic Nanozymes: A Comprehensive Review
Suryakanta Swain, Debashish Ghose, Bikash Ranjan Jena, GSN Koteswara Rao, Abhisek Sahu
Nanoscience and Nanotechnology Asia, 2023
Inhibitory effects of mixed flavonoid supplements on unraveled DSS-induced ulcerative colitis and arthritis
Siva Prasad Panda, Mahamat Sami Adam Mahamat, Malikyahia Abdul Rasool, DSNBK Prasanth, Idris Adam Ismail, Moyed Abasher Ahmed Abasher, Bikash Ranjan Jena
Bioimpacts, 2023
Formulation development, optimization and characterization of mucoadhesive minitablets of cefuroxime axetil: in vitro, ex vivo and in vivo pharmacokinetic evaluation
Jayanti Panda, Muddana Eswara Bhanoji Rao, Suryakanta Swain, Chinam Niranjan Patra, Bikash Ranjan Jena
Beni Suef University Journal of Basic and Applied Sciences, 2022
AQbD Driven Development of an RP-HPLC Method for the Quantitation of Abiraterone Acetate for its Pharmaceutical Formulations in the Presence of Degradants
Bikash Ranjan JENA, Siva Prasad PANDA, Umasankar KULANDAIVELU, Rajasekhar Reddy ALAVALA, G.S.N Koteswara RAO, Suryakanta SWAIN, Gurudutta PATTNAIK, Debashish GHOSE
Turkish Journal of Pharmaceutical Sciences, 2021
Analytical quality by design based systematic development and optimization of a sensitive bioanalytical method for estimation cinacalcet HCl in rabbit serum
ChinamNiranjan Patra, SudhanshuBhusan Routray, Suryakanta Swain, BikashRanjan Jena
Journal of Pharmacy and Bioallied Sciences, 2021
Design of Experiments for the Development of Solid Oral Dosage Forms
Sarwar Beg, Suryakanta Swain, Bikash Ranjan Jena
Design of Experiments for Pharmaceutical Product Development Volume II Applications and Practical Case Studies, 2021
Design of Experiments for the Development of Biotechnology Products
Suryakanta Swain, Bikash Ranjan Jena, Sarwar Beg
Design of Experiments for Pharmaceutical Product Development Volume II Applications and Practical Case Studies, 2021
QbD-based formulation optimization and characterization of polymeric nanoparticles of cinacalcet hydrochloride with improved biopharmaceutical attributes
Debashish GHOSE, Chinam Niranjan PATRA, Bera Varaha Venkata RAVI KUMAR, Suryakanta SWAIN, Bikash Ranjan JENA, Punam CHOUDHURY, Dipthi SHREE
Turkish Journal of Pharmaceutical Sciences, 2021
Applications of QBD-based software’s in analytical research and development
Bikash Ranjan Jena, Siva Prasad Panda, Kulandaivelu Umasankar, Suryakanta Swain, G.S.N Koteswara Rao, D. Damayanthi, Debashish Ghose, Debi Prasad Pradhan
Current Pharmaceutical Analysis, 2021
Analytical qbd based systematic development of a novel rp-uhplc method for the quantification of albuterol sulphate in its metered dose inhaler formulations
Bikash Ranjan JENA, Siva Prasad PANDA, Umasankar KULANDAIVELU, Rajasekhar Reddy ALAVALA
Journal of Research in Pharmacy, 2021
A trimethoxy flavonoid isolated from stem extract of Tabebuia chrysantha suppresses angiogenesis in angiosarcoma
Siva Prasad Panda, Uttam Prasad Panigrahy, DSNBK Prasanth, Uma Sankar Gorla, Chakravarthi Guntupalli, Deba Prasad Panda, Bikash Ranjan Jena
Journal of Pharmacy and Pharmacology, 2020
A QBD based study in development, optimization and forced degradation behaviour of epinastine hydrochloride in metered dose inhaler by RP-HPLC
International Journal of Pharmaceutical Research, 2020
Stem extract of Tabebuia chrysantha induces apoptosis by targeting sEGFR in Ehrlich Ascites Carcinoma
Siva Prasad Panda, Uttam Prasad Panigrahy, Subhranshu Panda, Bikash R. Jena
Journal of Ethnopharmacology, 2019
Quality by design: Concept to applications
Suryakanta Swain, Rabinarayan Parhi, Bikash Ranjan Jena, Sitty Manohar Babu
Current Drug Discovery Technologies, 2019
Application of Quality by Design Paradigms for Development of Solid Dosage Forms
Suryakanta Swain, Bikash Ranjan Jena, Dayaratnam Madugula, Sarwar Beg
Pharmaceutical Quality by Design Principles and Applications, 2019
Formulation development, statistical optimization and characterization of the self-microemulsifying drug delivery system (SMEDDS) of irbesartan
Suryakanta Swain, Sarwar Beg, Prafulla K. Sahu, Bikash R. Jena, Sitty M. Babu
Nanoscience and Nanotechnology Asia, 2019
Mucoadhesive multiparticulate drug delivery systems: An extensive review of patents
Someshwar Komati, Suryakanta Swain, Muddana Eswara Bhanoji Rao, Bikash Ranjan Jena, Vishali Dasi
Advanced Pharmaceutical Bulletin, 2019
Overexpressed CYP450 mediated apoptosis evaluates cytotoxicity and teratotoxicity of Cucumis callosus
Siva Prasad Panda, Bikash Ranjan Jena, Gade Kalyani, Uttam Prasad Panigrahy
Oriental Pharmacy and Experimental Medicine, 2018

RECENT SCHOLAR PUBLICATIONS

Nanomedicines for the management of atherosclerosis
R Parhi, BR Jena, A Panigrahi, S Swain
Nanobiomaterials and Nanomedicines for Metabolic Disorders, 515-551 , 2026
2026
Quality by Design Optimization of Telmisartan-loaded Self-nanoemulsifying Drug Delivery Systems
RL Maharana, S Swain, SK Mahapatra, BR Jena
Current Nanomedicine 16 (1), 95-114 , 2026
2026
Topical nanoparticles for the treatment of skin cancer: Present Concerns and Challenges
P Nayak, SK Swain, IJ Das, SS Swain, BR Jena, HB Samal
Journal of Drug Delivery Science and Technology, 107566 , 2025
2025
Citations: 2
Overcoming hurdles in oral protein and peptide drug delivery: Strategies for future prospective
P Parida, AK Prusty, RK Prusty, BR Jena, D Panda, S Das
Advancement in Animal Handling and Generative AI for Pre-clinical Studies, 28-41 , 2025
2025
Citations: 1
Development of in-situ ocular gel containing topiramate to understand its effect in intraocular pressure
B Puhan, A Panigrahi, G Sahu, Y Giri, BR Jena, G Pattnaik
Advancement in Animal Handling and Generative AI for Pre-clinical Studies … , 2025
2025
Development of sophisticated RP-HPLC approach for quantifying lornoxicam in API and pharmaceutical formulation
BM Sahoo, CK Brahma, BR Jena, K Mishra, D Panda, SN Tripathy, ...
Advancement in Animal Handling and Generative AI for Pre-clinical Studies … , 2025
2025
IONPs as strategic nanotools for cancer therapy: Concise updates on facile synthetic methods and stabilization
J Panda, S Rout, G Pattnaik, HB Samal, BR Jena, BS Satapathy
Advancement in Animal Handling and Generative AI for Pre-clinical Studies … , 2025
2025
Ionic gelation technique using biodegradable polymer for stabilized and sustained oral delivery of nano protein
P Parida, AK Prusty, C Sahoo, S Dash, BR Jena, K Mishra
Advancement in Animal Handling and Generative AI for Pre-clinical Studies, 22-27 , 2025
2025
Citations: 1
COVID-19: Immergence, molecular mechanism of transmission and pathogenesis
CC Behera, S Mishra, B Mishra, G Pattnaik, BR Jena, SK Mekap
Advancement in Animal Handling and Generative AI for Pre-clinical Studies … , 2025
2025
Exploring the In-Vitro Antibacterial and Anti Tubercular Activity of Lamotrigine through Repurposing Approach
N Pedamallu, MB Sitty, BL Raghunandhan, V Ramya, B Tripura, BR Jena
International symposium on Sustainable Drug Design and Nanoparticle … , 2025
2025
Biodegradable Polymer-based Nanoparticles: A Breakthrough in Oral Protein Drug Delivery
P Parida, AK Prusty, BR Jena, D Jena, C Sahoo
Nanoscience & Nanotechnology-Asia 15 (4), E22106812388555 , 2025
2025
Citations: 2
Liquisolid technique for solubility enhancement of poorly soluble drug-A brief review
A Prusty, BR Jena, V Barik, P Khamkat, BB Barik
Current Drug Discovery Technologies 22 (4), E15701638318659 , 2025
2025
Citations: 3
Development and Characterization of Ketoconazole-Loaded Nail Lacquer for the Topical Treatment of Onychomycosis.
PT Pradhan, A Panigrahi, J Ray, RS Dash, G Pattnaik, A Sahu, BR Jena, ...
Journal of Young Pharmacists 17 (3) , 2025
2025
Central composite design enabled formulation development, optimization, and characterization of bosutinib monohydrate loaded lipid nanoparticles: Cytotoxicity studies
D Panigrahi, SK Swain, BR Jena, P Parida, PK Sahu
Journal of Applied Pharmaceutical Science 15 (6), 137-155 , 2025
2025
Citations: 1
Biopolymers, Hydrogel and Their Effect on Drug Development
BR Jena, BN Ratha, G Pattnaik, NJ Kothakota, B Puhan, SS Islam, ...
Smart Ways of Biomaterial Designing Synthesis and Characterization, 152-170 , 2025
2025
Envisioning Clinical Management of Breast Cancer: a Comprehensive Review
S Das, G Pattnaik, S Pattanaik, BR Jena, BS Satapathy, A Pradhan
Current Drug Discovery Technologies 22 (2), E290424229495 , 2025
2025
Citations: 2
Controlled Drug Delivery Systems: Advancements and Recent Patents
S Swain, S Unnam, BR Jena, N Naidu, AT Pilla, H Chunduru, ...
International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN … , 2025
2025
Citations: 1
Autonomous Robots: A Disruptive Technology in the Health Sector
BR Jena, GSNK Rao, NJ Kothakota, RR Budha, L Srinivas, J Rajkumar, ...
Creating Smart Healthcare with Blockchain and Advanced Digital Technology … , 2025
2025
Citations: 4
Self-emulsifying Drug Delivery Systems: Concept to Applications, Regulatory Issues, Recent Patents, Current Challenges and Future Directions
RL Maharana, S Swain, SK Mahapatra, BR Jena
Current Pharmaceutical Biotechnology 26 (3), 341-364 , 2025
2025
Citations: 7
Exploring application & recent advances of response surface methodology driven approach in drug design and nanotechnology
A Panigrahi, BR Jena, SK Swain, HB Samal, PK Patra
2025

MOST CITED SCHOLAR PUBLICATIONS

Mucoadhesive Multiparticulate Drug Delivery Systems: An ExtensiveReview of Patents
S Komati, S Swain, ME Bhanoji Rao, BR Jena, V Dasi
Advanced Pharmaceutical Bulletin 9 (4), 521-538 , 2019
2019
Citations: 58
Quality by design: concept to applications
S Swain, R Parhi, BR Jena, SM Babu
Current drug discovery technologies 16 (3), 240-250 , 2019
2019
Citations: 55
QbD-based design and characterization of mucoadhesive microspheres of quetiapine fumarate with improved oral bioavailability and brain biodistribution potential
S Komati, S Swain, MEB Rao, BR Jena, S Unnam, V Dasi
Bulletin of Faculty of Pharmacy, Cairo University 56 (2), 129-145 , 2018
2018
Citations: 36
Qbd-Based Formulation Optimization and Characterization Of Polymeric Nanoparticles of Cinacalcet Hydrochloride with Improved Biopharmaceutical Attributes
D Ghose, CN Patro, BVVR Kumar, S Swain, BR Jena, D Punam Swain
Turkish Journal of Pharmaceutical Sciences, DOI:10.4274/tjps.galenos.2020.08522 , 2020
2020
Citations: 33
Stem extract of Tabebuia chrysantha induces apoptosis by targeting sEGFR in Ehrlich Ascites Carcinoma
SP Panda, UP Panigrahy, S Panda, BR Jena
Journal of ethnopharmacology 235, 219-226 , 2019
2019
Citations: 28
A trimethoxy flavonoid isolated from stem extract of Tabebuia chrysantha suppresses angiogenesis in angiosarcoma
SP Panda, UP Panigrahy, D Prasanth, US Gorla, C Guntupalli, DP Panda, ...
Journal of Pharmacy and Pharmacology 72 (7), 990-999 , 2020
2020
Citations: 23
Applications of QbD-based software’s in Analytical Research and Development
Bikash Ranjan Jena*, Siva Prasad Panda, Kulandaivelu Umasankar, Suryakanta ...
Current Pharmaceutical Analysis 16 (1) , 2020
2020
Citations: 18
Application of Quality by Design Paradigms for Development of Solid Dosage Forms
S Swain, BR Jena, D Madugula, S Beg
Pharmaceutical Quality by Design, 109-130 , 2019
2019
Citations: 18
AQbD Driven Development of a RP-HPLC Method for the Quantitation of Abiraterone acetate for Its Pharmaceutical Formulations in presence of Degradants
BR Jena, S Panda, U Kulandaivelu, AR Reddy, K Rao G.S.N, S Swain, ...
Turkish Journal of Pharmaceutical Sciences, DOI:0.4274/tjps.galenos.2021.74150 , 2021
2021
Citations: 16
Recent Developments and Applications of 3D-Printing Technology in Pharmaceutical Drug Delivery Systems: A New Research Direction and Future Trends
SK Swain, BR Jena, R Parhi
Current Pharmaceutical Design 31 (1), 2-25 , 2025
2025
Citations: 13
Formulation development, optimization and characterization of mucoadhesive minitablets of cefuroxime axetil: in vitro, ex vivo and in vivo pharmacokinetic evaluation
J Panda, MEB Rao, S Swain, CN Patra, BR Jena
Beni-Suef University Journal of Basic and Applied Sciences 11 (1), 123 , 2022
2022
Citations: 13
UPLC Analytical Method Development and Validation for the Simultaneous Estimation of Paracetamol and Caffeine Capsules Dosages Form
BR Jena, SM Babu, DP Pradhan, S Swain
Pharm Regul Aff 6 (186), 2-9 , 2017
2017
Citations: 12
Overexpressed CYP450 mediated apoptosis evaluates cytotoxicity and teratotoxicity of Cucumis callosus
SP Panda, BR Jena, G Kalyani, UP Panigrahy
Oriental Pharmacy and Experimental Medicine, 1-11 , 2018
2018
Citations: 10
Advancement and Applications of Platelet-inspired Nanoparticles: A Paradigm for Cancer Targeting
D Ghose, S Swain, CN Patra, BR Jena, MEB Rao
Current Pharmaceutical Biotechnology 24 (2), 213-237 , 2023
2023
Citations: 9
Current Advancements on Oral Protein and Peptide Drug Delivery Approaches to Bioavailability: Extensive Review on Patents
P Parida, AK Prusty, SK Patro, BR Jena
Recent Advances in Drug Delivery and Formulation 18 (4), 227-246 , 2024
2024
Citations: 8
Formulation Development, Statistical Optimization and Charac-terization of the Self-Microemulsifying Drug Delivery System (SMEDDS) of Irbesartan
Swain S, Beg S,Sahu P K,Jena BR, SM Babu
Nanoscience & Nanotechnology-Asia 8 , 2018
2018
Citations: 8
Self-emulsifying Drug Delivery Systems: Concept to Applications, Regulatory Issues, Recent Patents, Current Challenges and Future Directions
RL Maharana, S Swain, SK Mahapatra, BR Jena
Current Pharmaceutical Biotechnology 26 (3), 341-364 , 2025
2025
Citations: 7
New Validated UV Spectrophotometric Method for the Quantification of Bisoprolol Fumarate in its Pharmaceutical Dosage Form
SN Tripathy, S Swain, BR Jena, A Sahu
Acta Scientific Pharmaceutical Sciences (ISSN: 2581-5423) 7 (2) , 2023
2023
Citations: 7
Cleaning validation in analytical development: Current challenges and future prospectives
BR Jena, S Swain, DP Pradhan, D Ghose
Int J Pharm Chem Anal 7 (3), 113-118 , 2020
2020
Citations: 7
Emerging Applications of Medical Nanorobots in Health Care: Current Trends and Future Prospects
SK Swain, PK Sahu, BR Jena, B Acharya
Current Molecular Medicine , 2024
2024
Citations: 6

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

Expertise in Analytical Research and Development and Method Validations using statistical Multivariate analysis and Design of Experiments paradigim.
Expertise in QbD based softwares like Design Expert, Minitab, MatLab etc.
Sound knowledge of Analytical Quality by Design, Chemometrics, Various Statistical softwares and its immplementation
Handling of HPLC Instrumental softwares like Waters Empower 2, Shimadzu LC solution, n2000,
UV softwares like Win 5 and 6.2 etc.

Industry, Institute, or Organisation Collaboration

Worked at Analytical Research and Development, at Medreich Limited, Bengaluru, Karnataka.

INDUSTRY EXPERIENCE

Worked at Analytical Research and Development (A R & D), at Medreich Limited, Bengaluru, Karnataka during Dec 2011- Sept 2012.
I have worked in Celogen Pharma Pvt Ltd, Corporate Head office Navi Mumbai as Regulatory Affairs Executive from december 2012 to Dec 2013