Dr Mukesh Chandra SHarma

Scopus Publications

Streptomyces koyangensis L-asparaginase: computational prediction of dual-mechanism BCL-2 interaction in acute lymphoblastic leukemia
Gayatri Solanki, Chirag Prajapati, Rekha Gadhvi, Laxmikant Kamble, Mukesh Chandra Sharma, Sunil Tulshiram Hajare
Scientific Reports, 2026
The present research uses integrative computational analysis to assess Streptomyces koyangensis L-asparaginase as a therapeutic against acute lymphoblastic leukemia (ALL), overcoming immunogenicity and cross-reactivity issues with E. coli and Erwinia carotovora enzymes. We characterized enzyme-oncoprotein interactions using six in silico methods: homology modeling (SWISS-MODEL, AlphaFold2), molecular docking (ClusPro, HADDOCK, AutoDock Vina), 100 ns molecular dynamics (MD) (GROMACS), and pharmacophore modeling (LigandScout). Exceptional stability of the S. koyangensis-BCL-2 complex was revealed: binding energy − 13.8 kcal/mol; RMSD < 2.5 Å; Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBSA) -68.4 ± 5.2 kcal/mol, forming a 2,145 Å² interface with 80 interacting residues. Pharmacophore modeling identified eight features targeting Asp42, Glu78, and Arg156 for rational engineering. This suggests a potential dual mechanism involving asparagine depletion and predicted BCL-2 binding interactions that may enhance leukemic apoptosis, pending experimental validation. Comparative analysis confirmed S. koyangensis demonstrated statistically significant superior binding affinity compared to alternatives (P < 0.01), offering a computational framework for identifying potential anti-cancer biotherapeutic candidates requiring experimental validation.
Neuroprotective effects of Gynostemma pentaphyllum (Jiaogulan): Mechanisms, active compounds, and therapeutic potential
Ritesh Sharma, Kuldeep Singh, Deepak Sharma, Abhishek Sharma, Divya Jain, Subbulakshmi Packirisamy, Mukesh Chandra Sharma, Amitabh Shad
Pharmacological Research Modern Chinese Medicine, 2026
Neurodegenerative diseases such as Alzheimer’s and Parkinson’s involve oxidative stress, inflammation, and neuronal loss, with limited therapeutic options. Gynostemma pentaphyllum (Jiaogulan), a traditional Chinese medicinal herb rich in gypenosides, has demonstrated neuroprotective potential through antioxidant, anti-inflammatory, and neurogenic activities. This review synthesizes data from phytochemical, in vitro, in vivo , and limited clinical studies investigating the neuroprotective effects of Jiaogulan. Sources were selected from experimental models of oxidative stress, neuroinflammation, and neurodegeneration, focusing on mechanistic pathways, active compounds, and therapeutic relevance. Evidence indicates that Jiaogulan mitigates neuronal injury via multiple mechanisms, including activation of Nrf2/ARE signaling, inhibition of NF-κB/MAPK pathways, modulation of BDNF and PI3K/Akt signaling, protection against mitochondrial dysfunction, and acetylcholinesterase inhibition. Most available human studies evaluate the systemic antioxidant, anti-inflammatory, and metabolic effects of G. pentaphyllum . While these outcomes are not direct neurological endpoints, they are biologically relevant to neuroprotection, given the established links between systemic inflammation, oxidative stress, and neurodegenerative processes. Limited clinical data suggest improvements in oxidative stress, inflammation, and cognitive outcomes, with favorable safety profiles. The multi-target pharmacological profile of Jiaogulan aligns with the complex pathophysiology of neurodegenerative disorders. However, gaps remain regarding compound-specific mechanisms, pharmacokinetics, bioavailability, and large-scale clinical validation. Standardization of extracts and advanced delivery approaches may enhance translational potential. Gynostemma pentaphyllum represents a promising natural neuroprotective agent. With further mechanistic studies and well-designed clinical trials, Jiaogulan could emerge as a novel therapeutic candidate for the prevention and management of neurodegenerative diseases. Neuroprotective Effect of Gynostemma pentaphyllum (Jiaogulan): Mechanism, active compounds, and therapeutic use
Quantitative Structure–Activity Relationship in Drug Design
Satyamshyam Vishwakarma, Prashant Sahu, Pragyanshu Khare, Mukesh Chandra Sharma
Bioinformatics Computational Chemistry and AI in Drug Innovation Advances and Applications, 2026
3D-QSAR modeling is a computational technique that helps design bioactive compounds by establishing quantitative relationships between molecular features and observed biological activities. It builds upon classical QSAR, which uses 2D descriptors and topological indices, and incorporates spatial information, specifically steric and electrostatic fields. The core premise of 3D-QSAR is that biological activity is highly dependent on the spatial arrangement of atoms within a molecule, governing its ability to interact with a biological target. Key methodologies under 3D-QSAR include Comparative Molecular Field Analysis (CoMFA), Comparative Molecular Similarity Indices Analysis (CoMSIA), and Molecular Shape Analysis (MSA). The workflow involves selecting a dataset with known biological activity, molecular modeling and conformational analysis, alignment of molecules based on common structural features, computation of 3D descriptors, statistical modeling, and validation and interpretation of the model. 3D-QSAR has been widely applied in the pharmaceutical and agrochemical industries for hit-to-lead optimization, virtual screening, and lead refinement. This book chapter offers a critical analysis of 3D-QSAR’s ideas, methods, uses, and future directions. Among the fundamental methods covered are field-based QSAR models, MSA, CoMFA, and CoMSIA. With CoMFA concentrating on steric and electrostatic fields, CoMSIA expanding to hydrophobic and hydrogen bonding potentials, and MSA stressing the geometric alignment and spatial overlays of molecular forms, each approach presents particular benefits in simulating molecular interactions.
Psychological Interventions for the Management of Irritable Bowel Syndrome: Understanding the Mind-gut Connection
Neha Verma, Anchal Arora, Ankita Wal, Charan Singh, KS Rajesh, Bhupendra Singh, Mukesh Chandra Sharma
Current Psychiatry Research and Reviews, 2026
Objective: This review examines the efficacy of psychological interventions in the management of Irritable Bowel Syndrome (IBS). Methods: In the current study, a comprehensive analysis of the existing literature, covering case studies and clinical trials, compiled from Google Scholar, Sci-Hub, and PubMed, was performed. The research focused on the complex interplay between psychological factors and irritable bowel syndrome (IBS), particularly the ways in which mental and emotional states can impact IBS symptoms and the effects of behavioral therapy on IBS management. Results: The efficacy of psychological therapies in addressing irritable bowel syndrome (IBS) has proven effective. Cognitive Behavioral Therapy (CBT) treats pain perception and gastrointestinal symptoms, whereas gut-directed hypnotherapy is known for lowering symptoms and enhancing quality of life. Mindfulness- based stress reduction and relaxation practices are effective for stress management, but their availability is restricted. Personalized treatment strategies tailored to individual requirements are vital for enhancing the advantages of these therapies in IBS management. Conclusion: Psychological interventions provide a valuable and effective approach to managing IBS. CBT, gut-directed hypnotherapy, and MBSR have been shown to significantly improve symptoms and quality of life. Future research should focus on improving these therapies to better address individual symptoms and brain-gut connections. Incorporating neurological and neurophysiological approaches may improve understanding and lead to more tailored treatments. Expanding accessibility and encouraging collaboration between healthcare providers and mental health specialists will be vital for optimizing IBS management and improving patient outcomes.
Mechanistic and AI-assisted evaluation of paclitaxel-loaded HSPC liposomes for targeted breast cancer therapy
Vikram Subraya Shenoy, Prashant Nayak, Ramkumar Pillappan, Shrinivas R. Zanwar, Yogesh H. Bhosale, Devendra L. Bhuyar, Mukesh Chandra Sharma, Sunil Tulshiram Hajare
Naunyn Schmiedeberg S Archives of Pharmacology, 2026
Molecular Mechanisms of Neurodegeneration: A Focus on Cholinergic Dysfunction and the Therapeutic Potential of Rivastigmine Derivatives
Kuldeep Singh, Pranshul Sethi, Divya Jain, Jeetendra Kumar Gupta, Zaid Waqar, Bhupendra Singh, Rukhsar Syed, Mohammad Tabish, Mukesh Chandra Sharma
Current Topics in Medicinal Chemistry, 2026
Neurodegenerative diseases progressively impair neuronal structure and function, leading to cognitive decline, motor dysfunction, and paralysis. Among the underlying mechanisms, cholinergic dysfunction—characterized by degeneration of cholinergic neurons and reduced acetylcholine (ACh) levels—plays a central role in disease progression, particularly in Alzheimer’s disease (AD) and Parkinson’s disease (PD). According to the cholinergic hypothesis, memory loss and cognitive impairment are directly linked to disrupted ACh-mediated neurotransmission. Rivastigmine, a dual acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitor, enhances synaptic ACh levels but is limited by a short half-life, modest efficacy, and gastrointestinal side effects. This review highlights the molecular mechanisms underlying cholinergic dysfunction, including oxidative stress, mitochondrial impairment, protein aggregation, neuroinflammation, and synaptic dysregulation, while emphasizing rivastigmine and its derivatives as emerging therapeutic candidates. Structural modifications of rivastigmine have yielded multifunctional derivatives with improved selectivity, blood–brain barrier penetration, and neuroprotective properties, including antioxidant, anti-amyloid, and anti-inflammatory activities. These advances suggest that rivastigmine derivatives could serve as promising multi-targeted agents for neurodegenerative disorders. Future directions include integrating these compounds with nanotechnology-based delivery systems and precision medicine approaches to overcome pharmacokinetic limitations and optimize patient outcomes.
Insights into the Molecular Mechanisms of Neurodegenerative Diseases: Exploring Molecular Pathways and the Therapeutic Potential of Rivastigmine
Kuldeep Singh, Pranshul Sethi, Mamta Kumari, Jeetendra Kumar Gupta, Zaid Waqar, Divya Jain, Aakansha Verma, Alok Bhatt, Mukesh Chandra Sharma
CNS and Neurological Disorders Drug Targets, 2026
Neurodegenerative diseases are characterized by the progressive loss of neuronal function and structure, often leading to motor and cognitive impairments. The intricate molecular mechanisms underlying these diseases involve key pathways such as cholinergic signaling, oxidative stress, amyloid-beta aggregation, tau protein hyperphosphorylation, mitochondrial dysfunction, and neuroinflammation. Rivastigmine, a potent cholinesterase inhibitor, has emerged as a promising therapeutic agent due to its dual inhibitory effects on acetylcholinesterase and butyrylcholinesterase, enhancing cholinergic neurotransmission. This review provides a comprehensive overview of the molecular pathways implicated in neurodegenerative diseases and critically examines the therapeutic potential of Rivastigmine. Emphasis is placed on its mechanism of action, clinical efficacy, and limitations in addressing neurodegeneration. Current advancements, clinical trial outcomes, and potential future directions are discussed to highlight the utility of this approach in the treatment of neurodegenerative disorders.
The RhoA/ROCK pathway in vascular dysfunction and inflammation: Mechanisms and therapeutic targeting
Kuldeep Singh, Divya Jain, Arpan Kumar Tripathi, Touseef Begum, Mohammad Muztaba, Shamim Shamim Khan, Jeetendra Kumar Gupta, Abdullah Al Noman, Mukesh Chandra Sharma, Pranab Dev Sharma
European Journal of Inflammation, 2026
Cardiovascular diseases (CVDs) remain the foremost global cause of mortality, largely driven by endothelial dysfunction and vascular remodelling. The RhoA/Rho-associated coiled-coil containing protein kinase (ROCK) signalling pathway is central to vascular homeostasis, regulating vascular smooth muscle cell (VSMC) phenotypic plasticity, contraction, nitric oxide (NO) bioavailability, and cytoskeletal organization. Aberrant RhoA/ROCK activation contributes to hypertension, atherosclerosis, heart failure, and vascular stiffness through impaired endothelial function, oxidative stress, and maladaptive remodelling. This narrative review summarises current evidence on molecular mechanisms linking RhoA/ROCK activity with endothelial dysfunction and vascular pathology, highlighting its crosstalk with phosphoinositide-3-kinase–protein kinase B/Akt (PI3K-PKB/Akt), reactive oxygen species (ROS), and inflammatory mediators. Therapeutic insights focus on ROCK inhibitors, particularly fasudil, their limitations in isoform selectivity, and recent advances in structure-based drug design and targeted delivery systems. Isoform-specific and next-generation inhibitors represent a new frontier in therapy, with the potential to precisely suppress pathogenic RhoA/ROCK-driven inflammation, restore endothelial function, and markedly diminish cardiovascular disease burden.
Calcium alginate medicated dressing for enhanced absorption in diabetic foot ulcer management
Goswami Kaushal Puri, Rupalben Kaushalkumar Jania, Vijay Upadhye, Mukesh Chandra Sharma, Salah M. S. Hassan, Omar Awad Alsaidan, Sunil Tulshiram Hajare
Scientific Reports, 2025
Diabetic foot problems pose a substantial global health challenge as a major complication of diabetes mellitus. These issues encompass a spectrum of conditions affecting the feet of individuals with diabetes, including neuropathy (nerve damage), peripheral artery disease (impaired blood circulation), foot ulcers, infections, and, in critical situations, amputation. To mitigate the burden of lower extremity amputations, the development of innovative wound dressings and drug delivery systems is crucial. One such advancement is the "lyophilized wafer formulation," a recently developed medicated dressing material known for its rapid healing properties and high exudate absorption capacity in chronic wounds. Following successful completion of assessment tests for lymphatic fluid retention, viscosity, in vitro drug release, FTIR, DSC, and XRD, the exudate absorption capacity of calcium alginate was evaluated in the current study. Notably, the wafer formulation composed of 2% calcium alginate, 1% gelatin (bloom 150), and water as the solvent demonstrated excellent performance across exudate management properties, as well as in FTIR, DSC, XRD, and in vitro drug release assays using a dialysis membrane. This optimal formulation achieved a significant drug release of 96.9 ± 0.1% after 24 h. The Linezolid-loaded calcium alginate wafer formulation exhibited promising outcomes concerning antimicrobial properties, exudate handling, and drug release. Furthermore, the animal study indicated the absence of adverse effects, underscoring the formulation's potential as a safe and effective treatment for diabetic foot ulcers without inducing skin irritation. To fully realize its therapeutic value, comprehensive investigations into its stability profile and detailed pharmacological effects are strongly recommended.
Pro-oxidative effects of green tea polyphenols in Brugia malayi microfilariae: A mechanistic study
Sneha V. Hande, Suraj Wagh, Priyanka S. Bhoj, Kalyan Goswami, Vijay J. Upadhye, Mukesh Chandra Sharma, Sunil Tulshiram Hajare
Pharmacological Research Natural Products, 2025
Incretin Hormones: Mechanisms, Therapeutic Implications, and Future Directions in Glucose Regulation and Diabetes Management
Abrar Ahmad Zargar, Vipasha Mehta, Vitthal Huddar, Rishikesh Gupta, Kishwor Bhandari, Mahesh Kumar Posa, T. Sri Ramya, D. Snigdha, Vijayakumar B, Mukesh Chandra Sharma, P. Balaji, Sudhanshu Kumar Jha
Current Proteomics, 2025
Quality-by-Design (QbD) Assisted Synthesis of Nanoparticle for Efficient Loading, Stabilization, and Intracellular Delivery of Bioactive for the Treatment of Arthritis
Muktika Tekade, Mukesh Chandra Sharma
Indian Journal of Microbiology, 2025
Ginger (Zingiber officinale) in traditional Chinese medicine: A comprehensive review of its anti-inflammatory properties and clinical applications
Jitendra Gupta, Bhawna Sharma, Rahul Sorout, Ram Gopal Singh, Ittishree, Mukesh Chandra Sharma
Pharmacological Research Modern Chinese Medicine, 2025
Exploring synergistic benefits and clinical efficacy of turmeric in management of inflammatory and chronic diseases: A traditional Chinese medicine based review
Divya Jain, Kuldeep Singh, Paras Gupta, Jeetendra Kumar Gupta, Pankaj Kumar Sahu, Sumeet Dwivedi, Mukesh Chandra Sharma, Shivendra Kumar
Pharmacological Research Modern Chinese Medicine, 2025
Formulation and Development of Posaconazole Loaded Controlled Release Nanosponge Topical Gel for the Treatment of Fungal Infection
Rupal K. Jani, Zeel M. Patel, Kaushal J. Jani, Nidhi N. Patel, G. S. Chakraborthy, Vijay J. Upadhyay, Mukesh Chandra Sharma, Shailesh Wadher, Sunil Tulshiram Hajare
Journal of Pharmaceutical Innovation, 2025
Azoles, A Potential Anti Diabetic Agents as α- Glucosidase Inhibitors: Past, Current & Future Prospects
Deepanshu Sharma, Ganesh Prasad Mishra, Mukesh Chandra Sharma
Journal of Neonatal Surgery, 2025
Innovative Approaches in Molecular Docking for the Discovery of Novel Inhibitors Against Alzheimer's Disease
Bhoopendra Singh, Kuldeep Singh, Jeetendra Kumar Gupta, Bhupesh Chander Semwal, Divya Jain, Mukesh Chandra Sharma
Current Alzheimer Research, 2025
Advancements in Precision Oncology: Harnessing High-Throughput Screening and Computational Strategies for Targeted Cancer Therapies
Akshay Thakur, Kaunava Roy Chowdhury, Vir Vikram Sharma, Kuldeep Singh, Jeetendra Kumar Gupta, Divya Jain, Mukesh Chandra Sharma
Combinatorial Chemistry and High Throughput Screening, 2025
An Updated Review on the Complex Association of Cardiovascular Disease (CVD) and Depression
Namra Aziz, Tanya Tripathi, Anurag Rawat, Uttam Prasad Panigrahy, Darshan Jogi Chandrashekhar, Mukesh Chandra Sharma, Pranay Wal
Current Cardiology Reviews, 2025
A Delve into the Chemical Diversity, Pharmacological Targets, and Biological Mechanisms of Ichnocarpous frutescens Linn R. Br.: A Review on the Current Status of Knowledge
Jyotsana Dwivedi, Pranay Wal, Arunima Gupta, GunoSindhu Chakraborthy, Amulya Srivastava, Mukesh Chandra Sharma, Sachinkumar Dnyaneshwar Gunjal
Current Organic Chemistry, 2025
AI in Clinical Trials and Drug Development: Challenges and Potential Advancements
Divyanshi Gupta, Pranay Wal, Ankita Wal, Sribhavani K.R, Mudit kumar, Krishna Chandra Panda, Mukesh Chandra Sharma
Current Drug Discovery Technologies, 2025
Clinical Evidence of Traditional Medicines in Modulating the Immune Response and Diabetic Wound Healing
Jyotsana Dwivedi, Pranjal Sachan, Pranay Wal, Ankita Wal, Shanmugam Vippamakula, Rajesh K S, Mukesh Chandra Sharma
Current Topics in Medicinal Chemistry, 2025
Pandemic and Pregnancy: A Systematic Review on the Effect of the COVID-19 Drugs on Pregnant Women’s
Jyotsana Dwivedi, Amrita Verma Pargaien, Bhawana Chilwal, Arpita Bhakuni, Shubhi Kaushal, Richa Dayaramani, Mukesh Chandra Sharma
Coronaviruses, 2025
Comprehensive Review on Cervical Cancer: Global Health Burden
Namra Aziz, Vikrant Abbot, Aishwarya Bajpai, Pranay Wal, Ankita Wal, Rakesh Verma, Mukesh Chandra Sharma
Current Cancer Therapy Reviews, 2025
Advances in Artemisinin-based Therapies: Innovations in Synthesis, Drug Delivery, and Expanding Therapeutic Applications
Akshay Thakur, Gaurav Thakur, Vir Vikram Sharma, Kuldeep Singh, Jeetendra Kumar Gupta, Divya Jain, Mukesh Chandra Sharma
Recent Patents on Anti Cancer Drug Discovery, 2025
Pharmacological Activity of Scopoletin: Deciphering the Potential of  Coumarins in Cognitive Dysfunction
Pranay Wal, Shaili Vadera, Namra Aziz, Prashant -, Rajesh K S, Chennu MM Prasada Rao, Mukesh Chandra Sharma
Current Drug Research Reviews, 2025
Emulgel-Based Formulations of Clobetasol Propionate: Formulation Development, Characterization, and Pharmacological Evaluation
Kuldeep Singh, Jeetendra Kumar Gupta, Divya Jain, Mukesh Chandra Sharma, Shivendra Kumar, Ramkumar Chaudhary, Sakshi Mishra
Pharmaceutical Nanotechnology, 2025
Emerging Applications and Innovations in Emulgel Technology for Enhanced Topical Drug Delivery
Kuldeep Singh, Jeetendra Kumar Gupta, Shamim -, Mohammad Muztaba, Shaheena Sohi, Jailani. S, Mukesh Chandra Sharma, Divya Jain
Drug Delivery Letters, 2025
Endometriosis: A Comprehensive and Concise Review of Potential Biomarkers and Treatment Therapies
Namra Aziz, Pranay Wal, Chandana Pyne, Shweta Singh, Sudarshan N. Borkar, Swarnima Pandey, Mukesh Chandra Sharma
Current Drug Therapy, 2025
Advance Nanotechnology-Based Drug Delivery Systems for Alzheimer's Disease: Advancements and Future Perspectives
Kuldeep Singh, Jeetendra Kumar Gupta, Gaurav Lakhchora, Divya Jain, Alok Bhatt, Mukesh Chandra Sharma, MVNL Chaitanya, Mohammad Tabish
Current Alzheimer Research, 2025
Research on Alzheimer's Disease (AD) Involving the Use of In Vivo and In Vitro Models and Mechanisms
Sweta Sinha, Pranay Wal, Prakash Goudanavar, Surisetti Divya, Vishwadeepak Kimothi, Divya Jyothi, Mukesh Chandra Sharma, Ankita Wal
Central Nervous System Agents in Medicinal Chemistry, 2025
Phytochemistry, Pharmacological Targets, Biological Mechanisms and Patented Formulations of Salacia reticulata Wight (Celastaceae): An Appraisal of its Potential
Pranay Wal, Jyotsana Dwivedi, Shubhi Kaushal, Tatapudi Naga Aparna, Pulagurtha Bhaskararao, Devendra Kumar Sahu, Onkar Bedi, Mukesh Chandra Sharma
Current Organic Chemistry, 2025
Exploring the Dual Roles of Neural Stem Cells in Glioblastoma: Therapeutic Implications and Opportunities
Kuldeep Singh, Pranshul Sethi, Jeetendra Kumar Gupta, Anubhav Dubey, Mukesh Chandra Sharma, Divya Jain, Alok Bhatt, Shivendra Kumar
Current Stem Cell Research and Therapy, 2025
Biomarkers and Novel Therapies of Diabetic Neuropathy: An Updated Review
Namra Aziz, Shital Vijay Nehere, Rishika Sinha, Rajeev Satyarthy, Harshit Prajapati, Uttam Prasad Panigrahy, Mukesh Chandra Sharma, Pankaj Kumar, Pranay Wal
Current Pharmaceutical Biotechnology, 2025
Immune Modulation Strategies in Gene Therapy: Overcoming Immune Barriers and Enhancing Efficacy
Sivaprakasam S. Amsaveni, Radha Mahendran, Vidhya C. S., Dilip Kumar Chanchal, Sojomon Mathew, Mukesh Chandra Sharma, Jailani S., Syed Salman Ali
Current Gene Therapy, 2025
Molecular Mechanisms and Pathways of Mesenchymal Stem Cell-mediated Therapy in Brain Cancer
Kuldeep Singh, Geetanjali Singh, Jeetendra Kumar Gupta, Alka N Choudhary, Arun Kumar, Divya Jain, Mukesh Chandra Sharma, Shivendra Kumar
Current Stem Cell Research and Therapy, 2025
Herbal Antibiotics: A Review of Traditional Medicinal Plants with Antibacterial Properties and Their Potential for Future Treatment
Shirode Prashant Ramesh, Santosh Karajgi, Riya Singh, Pravin Naik, Ujjwal Sahoo, Mukesh Chandra Sharma, Pankaj Nainwal, Ankita Wal
Anti Infective Agents, 2025
Comorbidity of Depression and Diabetes: A Literature Review on Systemic Flaws in Healthcare and the Benefits of Collaborative Diagnosis and Treatment in Primary Care Settings
Pranay Wal, Pankaj Kumar, Harsh Bhardwaj, Komal Sharma, Arpan Kumar Tripathi, Arpit Gupta, Ankita Wal, Mukesh Chandra Sharma
Current Diabetes Reviews, 2025
Advances in Molecular Docking Techniques for Targeting Protein Misfolding in Neurodegenerative Diseases
Kuldeep Singh, Jeetendra Kumar Gupta, Shiv Narayan, Ketki Rani, Divya Jain, Prateek Porwal, Mukesh Chandra Sharma, Shivendra Kumar
Current Pharmaceutical Biotechnology, 2025
Precision Medicine in Neurodegenerative Diseases: Genomic Approaches to Target Amyloid-β, Tau, and Alpha-Synuclein Pathways
Zaid Waqar, Pranshul Sethi, Divya Jain, Kuldeep Singh, Omar Awad Alsaidan, Sami I. Alzarea, Jeetendra Kumar Gupta, Swati Saxena, Mukesh Chandra Sharma
Current Genomics, 2025
Unveiling the therapeutic potential of traditional Chinese medicine Rhizome Coptidis: A comprehensive review
Kuldeep Singh, Jeetendra Kumar Gupta, Divya Jain, Alka N Chaudhary, Shivendra Kumar, Mukesh Chandra Sharma, Bhupendra Singh
Pharmacological Research Modern Chinese Medicine, 2024
Detailed review on phytosomal formulation attenuating new pharmacological therapies
Jyotsana Dwivedi, Pranjal Sachan, Pranay Wal, Sumeet Dwivedi, Mukesh Chandra Sharma, Surada Prakash Rao
Advances in Traditional Medicine, 2024
Polymer mediated light responsive therapeutics delivery system to treat cancer
Devesh Kapoor, Neha Maheshwari, Anindita Bag, Mukesh C. Sharma, Bhupendra Prajapati, Rahul Maheshwari
European Polymer Journal, 2024
Rapid, Simple and Low-Cost Reverse-Phase High-Performance Liquid Chromatography Tool for Estimation of Methotrexate: Testing Application in Standard Laboratory Bulk, Marketed Dosage Form, and Release kinetics in Nanoformulation
Muktika Tekade, Mukesh Chandra Sharma
Indian Journal of Pharmaceutical Education and Research, 2024
Metallic nanoparticles in cancer: Types, green synthesis, applications, tumor microenvironment and toxicity considerations
Devesh Kapoor, Neha Maheshwari, Namrita Soni, Nidhi Jain Singhai, Mukesh C. Sharma, Bhupendra Prajapati, Santosh Yele, Rahul Maheshwari
Journal of Drug Delivery Science and Technology, 2024
Photoresponsive 'chemo-free' phytotherapy: formulation development for the treatment of triple-negative breast cancer
Neha Maheshwari, Mukesh C Sharma
Nanomedicine, 2024
A Comprehensive Review on the Significance of Cysteine in Various Metabolic Disorders; Particularly CVD, Diabetes, Renal Dysfunction, and Ischemic Stroke
Namra Aziz, Pranay Wal, Rishika Sinha, Prashant Ramesh Shirode, GunoSindhu Chakraborthy, Mukesh Chandra Sharma, Pankaj Kumar
Current Protein and Peptide Science, 2024
Recent Advances in the Synthesis of Antioxidant Derivatives: Pharmacological Insights for Neurological Disorders
Kuldeep Singh, Jeetendra Kumar Gupta, Pranshul Sethi, Sojomon Mathew, Alok Bhatt, Mukesh Chandra Sharma, Sunam Saha, Shamim, Shivendra Kumar
Current Topics in Medicinal Chemistry, 2024
Anticancer Properties of Some Selected Plant Phenolic Compounds: Future Leads for Therapeutic Development
N. Maheshwari, M.C. Sharma
Journal of Herbal Medicine, 2023
32 Factorial Design of O/W Nanoemulsions of Cholecalciferol Using Box–Behnken Model for Plaque Psoriasis
Mukesh Chandra Sharma, Mukul Sharma
Indian Journal of Pharmaceutical Education and Research, 2023
Novel applications of Cold Atmospheric Plasma for the treatment of Plaque Psoriasis
Mukesh Chandra Sharma, Mukul Sharma
Research Journal of Pharmacy and Technology, 2023
Recent Advances in Polymer-Based Nanomaterials for Non-Invasive Photothermal Therapy of Arthritis
Muktika Tekade, Prashant Pingale, Rachna Gupta, Bhakti Pawar, Rakesh Kumar Tekade, Mukesh Chandra Sharma
Pharmaceutics, 2023
Clinical detoxification of the body from chemical toxicants
Muktika Tekade, Prashant L. Pingale, Sakshi P. Wani, Kuldeep Rajpoot, Nagaraja Sreeharsha, Mrudul Deshpande, Rakesh Kumar Tekade, Mukesh C. Sharma
Essentials of Pharmatoxicology in Drug Research Toxicity and Toxicodynamics Volume 1, 2023
Designing of novel nanoemulsions of retinol using box Behnken design for psoriasis
Mukul Sharma, Mukesh Chandra Sharma, Rakhi Khabiya, Akanksha Dwivedi, Alankar Shrivastava, G.P. Choudhary, Shivani Dubey, Sanjay Jain
Materials Today Proceedings, 2023
Laser empowered ‘chemo-free’ phytotherapy: Newer approach in anticancer therapeutics delivery
Neha Maheshwari, Mukesh C. Sharma
Journal of Drug Delivery Science and Technology, 2022
2D QSAR STUDIES OF NOVEL TRIAZOLINONE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS USING TOPOLOGICAL DESCRIPTORS
Mukesh C. Sharma,, D. V. Kohli
Indian Drugs, 2022
Food-drug interactions and their implications on oral drug bioavailability
Suryanarayana Polaka, Kuldeep Rajpoot, Muktika Tekade, Mukesh Chandra Sharma, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Impact of ageing on the pharmacokinetics and pharmacodynamics of the drugs
Suryanarayana Polaka, Jai Divya Tella, Muktika Tekade, Mukesh Chandra Sharma, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Methods and models for in vitro toxicity
Rachna Gupta, Kuldeep Rajpoot, Muktika Tekade, Mukesh Chandra Sharma, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Principles and concepts in toxicokinetic
Kuldeep Rajpoot, Muktika Tekade, Mukesh Chandra Sharma, Basel Arafat, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Organ-on-chip for assessing environmental toxicants
Suryanarayana Polaka, Priyanka Pulugu, Muktika Tekade, Mukesh Chandra Sharma, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Zebrafish models for toxicological screening
Suryanarayana Polaka, HariPriya Koppisetti, Shreya Pande, Muktika Tekade, Mukesh Chandra Sharma, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Excipient toxicity and safety
Vikas Pandey, Suryanarayana Polaka, Lakshmi Vineela Nalla, Muktika Tekade, Mukesh Chandra Sharma, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Factors influencing drug toxicity
Rachna Gupta, Kuldeep Rajpoot, Muktika Tekade, Mukesh Chandra Sharma, Maliheh Safavi, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Importance of toxicity testing in drug discovery and research
Rachna Gupta, Suryanarayana Polaka, Kuldeep Rajpoot, Muktika Tekade, Mukesh Chandra Sharma, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Drug-drug interactions and their implications on the pharmacokinetics of the drugs
Suryanarayana Polaka, Hari Priya Koppisetti, Muktika Tekade, Mukesh Chandra Sharma, Pinaki Sengupta, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Clinical importance of herb-drug interaction
Suryanarayana Polaka, Sayali Chaudhari, Muktika Tekade, Mukesh Chandra Sharma, Neelesh Malviya, Sapna Malviya, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Molecular biology of apoptotic, necrotic, and necroptotic cell death
Suryanarayana Polaka, Hari Priya Koppisetti, Rutuja Satvase, Aparna Lakshmi Manchikalapudi, Muktika Tekade, Mukesh Chandra Sharma, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
In silico methods for the prediction of drug toxicity
Kuldeep Rajpoot, Nimeet Desai, HariPriya Koppisetti, Muktika Tekade, Mukesh Chandra Sharma, Santosh Kumar Behera, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Toxicokinetic and toxicodynamic considerations in drug research
Kuldeep Rajpoot, Pratik Katare, Muktika Tekade, Mukesh Chandra Sharma, Suryanarayana Polaka, Pinaki Sengupta, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Understanding the concept of signal toxicity and its implications on human health
Muktika Tekade, HariPriya Koppisetti, Mukesh Chandra Sharma, Kuldeep Rajpoot, Pinaki Sengupta, Manoj Kumar, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Pharmaceutical excipients: Special focus on adverse interactions
Suryanarayana Polaka, Shyam Sudhakar Gomte, Vikas Pandey, Jai Divya Tella, Muktika Tekade, Mukesh Chandra Sharma, Nagashekhara Molugulu, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Toxicity and toxicokinetic considerations in product development and drug research
Saket Asati, Vikas Pandey, Vishal Gour, Rahul Tiwari, Vandana Soni, Kuldeep Rajpoot, Muktika Tekade, Mukesh Chandra Sharma, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Emerging role of novel excipients in drug product development and their safety concerns
Suryanarayana Polaka, Bhakti Pawar, Muktika Tekade, Rutuja Satvase, Aparna Lakshmi Manchikalapudi, Mukesh Chandra Sharma, Vikas Pandey, Aditya Narayan Jhariya, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Toxicogenomics in drug safety assessment
Suryanarayana Polaka, Nupur Vasdev, Sivaroopa Raji, Vaishali Makwana, Amarjitsing Rajput, Madhur Kulkarni, Muktika Tekade, Prashant Pingale, Mukesh Chandra Sharma, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
New emerging technologies for genetic toxicity testing
Nupur Vasdev, Mrudul Deshpande, Pratik Katare, Vaishali Makwana, Suryanarayana Polaka, Muktika Tekade, Pinaki Sengupta, Mukesh Chandra Sharma, Dinesh Kumar Mishra, Rakesh Kumar Tekade
Pharmacokinetics and Toxicokinetic Considerations Vol II, 2022
Structural feature study of quinolines derivatives with thermodynamic and other descriptors: A qsar approach
Mukesh C. Sharma, Dharm V. Kohli, Department of Pharmaceutical Chemistry, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore - 452 001,Madhya Pradesh, India
Indian Drugs, 2021
Development and validation of RP-HPLC method for simultaneous estimation of clidinium bromide, chlordiazepoxide and dicyclomine hydrochloride in tablet dosage form
Rajesh Sharma, Mukesh C. Sharma, Gaurav Vijaywargiya, School of Pharmacy, Devi Ahilya Vishwavidyalaya Takshashila Campus, Khandwa Road, Indore - 452 001, Madhya Pradesh, India
Indian Drugs, 2021
Simultaneous determination of paracetamol, aceclofenac and tramadol hydrochloride in pharmaceutical dosage form by RP-HPLC method
Indian Drugs, 2021
Pharmacokinetics and biopharmaceutics: “a leader or attendant”
Kuldeep Rajpoot, Rakesh Kumar Tekade, Mukesh Chandra Sharma, Muktika Tekade
Biopharmaceutics and Pharmacokinetics Considerations Volume 1 in Advances in Pharmaceutical Product Development and Research, 2021
Pharmacokinetics modeling in drug delivery
Kuldeep Rajpoot, Rakesh Kumar Tekade, Mukesh Chandra Sharma, Maliheh Safavi, Muktika Tekade
Biopharmaceutics and Pharmacokinetics Considerations Volume 1 in Advances in Pharmaceutical Product Development and Research, 2021
Biopharmaceutical considerations in the pediatric and geriatric formulation development
Kuldeep Rajpoot, Rakesh Kumar Tekade, Bappaditya Chatterjee, Mukesh Chandra Sharma, Muktika Tekade
Biopharmaceutics and Pharmacokinetics Considerations Volume 1 in Advances in Pharmaceutical Product Development and Research, 2021
Influence of fever on pharmacokinetics of drugs
Nimeet Desai, HariPriya Koppisetti, Kuldeep Rajpoot, Muktika Tekade, Mukesh Chandra Sharma, Rakesh Kumar Tekade
Biopharmaceutics and Pharmacokinetics Considerations Volume 1 in Advances in Pharmaceutical Product Development and Research, 2021
Structural requirements of some Triazolone derivatives using topological and physicochemical descriptors: QSAR approach
Indian Drugs, 2020
New advances in insulin products
Kuldeep Rajpoot, Muktika Tekade, Mukesh Chandra Sharma, Nagashekhara Molugulu, Rakesh K. Tekade
Future of Pharmaceutical Product Development and Research, 2020
Recent advancements in solubilization of hydrophobic drugs
Kuldeep Rajpoot, Muktika Tekade, Nagaraja Sreeharsha, Mukesh C. Sharma, Rakesh K. Tekade
Future of Pharmaceutical Product Development and Research, 2020
3D printing as an emerging tool in pharmaceutical product development
Kuldeep Rajpoot, Muktika Tekade, Mukesh Chandra Sharma, Nagaraja Sreeharsha, Basel Arafat, Rakesh K. Tekade
Future of Pharmaceutical Product Development and Research, 2020
Recombinant blood products and therapeutic enzymes: An update
Kuldeep Rajpoot, Muktika Tekade, Mukesh Chandra Sharma, Nagaraja Sreeharsha, Anita Sharma, Rakesh K. Tekade
Future of Pharmaceutical Product Development and Research, 2020
Resealed erythrocytes (RBCs) and their biomedical application
Satish Shilpi, Kuldeep Rajpoot, Muktika Tekade, Mukesh C. Sharma, Susanne R. Youngren-Ortiz, Pran Kishore Deb, Abhay S. Chauhan, Rakesh K. Tekade
Future of Pharmaceutical Product Development and Research, 2020
Molecular modeling study of uracil-based hydroxamic acids-containing histone deacetylase inhibitors
Mukesh C. Sharma, Smita Sharma
Arabian Journal of Chemistry, 2019
Design and prediction of favorable substitution site in trifluorophenyl-substituted homopiperazine, pyrazoline, triazepane derivatives as dipeptidyl peptidase IV Inhibitors: HQSAR and docking studies
M. C. Sharma, S. Jain
Network Modeling Analysis in Health Informatics and Bioinformatics, 2019
Approaches to the Development of Implantable Therapeutic Systems
Ankita Mane, Neha Maheshwari, Piyush Ghode, Mukesh Chandra Sharma, Rakesh K. Tekade
Biomaterials and Bionanotechnology, 2019
Nanotechnology in Tissue Engineering
Neha Maheshwari, Muktika Tekade, Yashu Chourasiya, Mukesh Chandra Sharma, Pran Kishore Deb, Rakesh K. Tekade
Biomaterials and Bionanotechnology, 2019
Guiding Factors and Surface Modification Strategies for Biomaterials in Pharmaceutical Product Development
Neha Maheshwari, Umesh Kumar Atneriya, Muktika Tekade, Mukesh Chandra Sharma, Abdelbary Elhissi, Rakesh K. Tekade
Biomaterials and Bionanotechnology, 2019
Up-to-Date Implications of Nanomaterials in Dental Science
Muktika Tekade, Neha Maheshwari, Hira Choudhury, Bapi Gorain, Pran Kishore Deb, Rakesh K. Tekade, Mukesh Chandra Sharma
Biomaterials and Bionanotechnology, 2019
Functionalized Carbon Nanotubes for Protein, Peptide, and Gene Delivery
Neha Maheshwari, Muktika Tekade, Namrata Soni, Piyush Ghode, Mukesh Chandra Sharma, Pran Kishore Deb, Rakesh K. Tekade
Biomaterials and Bionanotechnology, 2019
Thiolated-Chitosan: A Novel Mucoadhesive Polymer for Better-Targeted Drug Delivery
Muktika Tekade, Neha Maheshwari, Susanne R. Youngren-Ortiz, Vikas Pandey, Yashu Chourasiya, Vandana Soni, Pran Kishore Deb, Mukesh Chandra Sharma
Biomaterials and Bionanotechnology, 2019
Insight into the structural requirements of sulfonyl derivatives based on Two and Three-dimensional descriptors: QSAR Studies
Indian Drugs, 2019
Three-dimensional QSAR modeling benzimidazole Analogues using the k-nearest neighbor method
Indian Drugs, 2019
Graphene-based hybrid nanoparticle of doxorubicin for cancer chemotherapy
Nagaraja SreeHarsha, Rahul Maheshwari, Bandar E Al-Dhubiab, Muktika Tekade, Mukesh Chandra Sharma, Katharigatta N Venugopala, Rakesh Kumar Tekade, Abdullah M Alzahrani
International Journal of Nanomedicine, 2019
Probing the structural requirements for angiotensin II receptor: molecular modeling studies
M. C. Sharma, Dharm V. Kohli
Network Modeling Analysis in Health Informatics and Bioinformatics, 2018
Trifluorophenyl-based inhibitors of dipeptidyl peptidase-IV as antidiabetic agents: 3D-QSAR COMFA, CoMSIA methodologies
M. C. Sharma, S. Jain, R. Sharma
Network Modeling Analysis in Health Informatics and Bioinformatics, 2018
Synthesis and characterization of some isoxazole derivatives for antimicrobial activity
Umakant, D. Sharma, D. Pathak, G. Sharma, M. C. Sharma, Rajiv Academy for Pharmacy, Chhattikara, Mathura - 281 001, Uttar Pradesh, India
Indian Drugs, 2018
Development of a credible QSAR and K Nearest Neighbor models for imidazolyl derivatives
Indian Drugs, 2018
Prediction of biological activity of substituted 2,5-dibutyl-2,4-dihydro derivatives by 3D-quantitative structure activity relationship (QSAR) results
Journal of the Balkan Tribological Association, 2018
Predicting potent antihypertensive compounds of pyridine derivatives by Molecular modeling approach
Indian Drugs, 2018
Prediction of structural requirements of AT1 receptor through application of pharmacophore-based 3D-QSAR studies
M. C. Sharma, D. V. Kohli
Network Modeling Analysis in Health Informatics and Bioinformatics, 2017
Exploration of new scaffolds pyrazole derivatives containing thiourea skeleton as anticancer activity using QSAR approach
M. C. Sharma, S. Sharma
Network Modeling Analysis in Health Informatics and Bioinformatics, 2017
Quantitative structure-activity relationship studies of some benzimidazole analogues basing on partial least squares method
Indian Drugs, 2017
Quantitative structure activity relationship modeling for prediction of pyridine substituted analogues with k-Nearest Neighbor studies
Indian Drugs, 2017
Predictive QSAR modeling of pyridazinyl derivatives using k-nearest neighbor and pharmacophore approach
Indian Drugs, 2017
Development of a robust QSAR model of angiotensin receptor reveals a k nearest neighbor applicable to diverse scaffolds
Indian Drugs, 2017
SYNTHESIS AND EVALUATION OF ANTIBACTERIAL, ANTHELMINTIC ACTIVITIES OF SUBSTITUTED BENZIMIDAZOLE DERIVATIVES
D Sharma, G. K Sharma, D. Pathak, M. C. Sharma, Aligarh College of Pharmacy, Aligarh - 202 001, Uttar Pradesh, India.
Indian Drugs, 2017
A QSAR study of substituted pyrazoline derivatives as potential anti-tuberculosis agents
Indian Drugs, 2017
QSAR approach to the study of the EGFR tyrosine kinase inhibitors: Thiazolyl-pyrazoline derivatives
Indian Drugs, 2017
Development and validation of new analytical methods for simultaneous estimation of Drotaverine hydrochloride in combination with Omeprazole in a pharmaceutical dosage form
Smita Sharma, Mukesh C. Sharma
Arabian Journal of Chemistry, 2017
Simultaneous determination of Nitazoxanide and Ofloxacin in pharmaceutical preparations using UV-spectrophotometric and high performance thin layer chromatography methods
Smita Sharma, Mukesh C. Sharma, Nitendra K. Sahu
Arabian Journal of Chemistry, 2017
Structural insights into mode of actions of dipeptidyl peptidase IV inhibitors as anti-diabetic agents: Computational analyses
Journal of the Balkan Tribological Association, 2017
Development of a credible QSAR studies for a series of sulphonamides derivatives
Journal of the Balkan Tribological Association, 2017
Exploration of important sites of angiotensin II AT1 receptor of Pyrido [2, 3-d] pyrimidine analogues for structural modification using computational approach
M. C. Sharma, S. Sharma
Network Modeling Analysis in Health Informatics and Bioinformatics, 2017
Rationalization of physicochemical characters and structural determinants of benzimidazole analogues as casein kinase 2 inhibitors: computational approach
Mukesh C. Sharma
Network Modeling Analysis in Health Informatics and Bioinformatics, 2016
Computational design of novel renin inhibitors of indole-3-carboxamide derivatives through QSAR studies
Mukesh C. Sharma
Network Modeling Analysis in Health Informatics and Bioinformatics, 2016
Investigation on Quantitative Structure Activity Relationships of a Series of Inducible Nitric Oxide
Mukesh C. Sharma, S. Sharma
Interdisciplinary Sciences Computational Life Sciences, 2016
Computational study of diarylcyclopentene derivatives as selective prostaglandin EP1 receptor antagonist: QSAR approach
Mukesh C. Sharma, Smita Sharma, Shivangi Sharma
Network Modeling Analysis in Health Informatics and Bioinformatics, 2016
QSAR studies on pyrazolo [1, 5-a] pyrimidine-based Pim-1 kinase inhibitors
Indian Drugs, 2016
Development and validation of Spectrophotometric method and TLC Densitometric Determination of Irinotecan HCl in pharmaceutical dosage forms
Smita Sharma, Mukesh C. Sharma
Arabian Journal of Chemistry, 2016
Molecular modeling studies of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4-one derivatives as phosphatase SerB653 inhibitors
Mukesh C. Sharma, Smita Sharma
Medicinal Chemistry Research, 2016
Structural feature study of furoxan derivatives as potent anti-trypanosomatid agents: QSAR approach
Indian Drugs, 2016
Optimization of antiproliferative activity of synthetic uredio-substituted sulfamate derivatives: QSAR approach
Indian Drugs, 2016
Identification of 3-Nitro-2,4,6-trihydroxybenzamide Derivatives as Photosynthetic Electron Transport Inhibitors by QSAR and Pharmacophore Studies
Mukesh C. Sharma
Interdisciplinary Sciences Computational Life Sciences, 2016
Structural Requirements of Some 2-(1-Propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide Derivatives as Poly (ADP-Ribose) Polymerase (PARP) for the Treatment of Cancer: QSAR Approach
Mukesh C. Sharma
Interdisciplinary Sciences Computational Life Sciences, 2016
A structure–activity relationship study of imidazole-5-carboxylic acid derivatives as angiotensin II receptor antagonists combining 2D and 3D QSAR methods
Mukesh C. Sharma
Interdisciplinary Sciences Computational Life Sciences, 2016
2D QSAR studies of the inhibitory activity of a series of substituted purine derivatives against c-Src tyrosine kinase
Mukesh C. Sharma
Journal of Taibah University for Science, 2016
QSAR studies of novel 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives and their precursors as antileukaemic agents
Mukesh C. Sharma
Journal of Taibah University for Science, 2016
Validated RP-HPLC method for determining the levels of bromhexine HCl, chlorpheniramine maleate, dextromethorphan HBr and guaiphenesin in their pharmaceutical dosage forms
Vishal Jain, Mukesh C. Sharma
Journal of Taibah University for Science, 2016
QSAR studies on pyrazole-4-carboxamide derivatives as Aurora A kinase inhibitors
Mukesh C. Sharma, Smita Sharma, K.S. Bhadoriya
Journal of Taibah University for Science, 2016
RP-HPLC-PDAAnalyses of Tapentadol: Application of Experimental Design
Dinesh M. Dhumal, Saurabh B. Ganorkar, Mrunal U. Patil, Digvijay Singh, Mukesh C. Sharma, Kamlendra Singh Bhadoriya
Analytical Chemistry Letters, 2016
A Structure–Activity Relationship Study of Naphthoquinone Derivatives as Antitubercular Agents Using Molecular Modeling Techniques
Mukesh C. Sharma
Interdisciplinary Sciences Computational Life Sciences, 2015
A comparative QSAR analysis of substituted imidazolones derivatives as angiotensin II AT1 receptor antagonists
Mukesh C. Sharma
Network Modeling Analysis in Health Informatics and Bioinformatics, 2015
Prospective QSAR-Based Prediction Models with Pharmacophore Studies of Oxadiazole-Substituted α-Isopropoxy Phenylpropanoic Acids with Dual Activators of PPAR α and PPAR γ
Mukesh C. Sharma
Interdisciplinary Sciences Computational Life Sciences, 2015
Predictive QSAR modeling of substituted Phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists: computational approach
Mukesh C. Sharma
Network Modeling Analysis in Health Informatics and Bioinformatics, 2015
Structural features of substituted triazole-linked chalcone derivatives as antimalarial activities against D10 strains of Plasmodium falciparum: A QSAR approach
Mukesh C. Sharma
Journal of Central South University, 2015
Discovery of Potent Antihypertensive Ligands Substituted Imidazolyl Biphenyl Sulfonylureas Analogs as Angiotensin II AT1 Receptor Antagonists by Molecular Modelling Studies
Mukesh C. Sharma
Interdisciplinary Sciences Computational Life Sciences, 2015
Comparative Pharmacophore Modeling and QSAR Studies for Structural Requirements of some Substituted 2-Aminopyridine Derivatives as Inhibitors of Nitric Oxide Synthases
Mukesh C. Sharma
Interdisciplinary Sciences Computational Life Sciences, 2015
QSAR studies on 3-(4-biphenylmethyl) 4, 5-dihydro-4-oxo-3H-imidazo [4, 5-c] Pyridine derivatives as angiotensin II (AT1) receptor antagonist
Mukesh C. Sharma
Interdisciplinary Sciences Computational Life Sciences, 2015
A click chemistry strategy to synthesize geraniol-coupled 1,4-disubstituted 1,2,3-triazoles and exploration of their microbicidal and antioxidant potential with molecular docking profile
Nitin Dubey, Mukesh C. Sharma, Ashok Kumar, Pratibha Sharma
Medicinal Chemistry Research, 2015
Pharmacophore modeling and atom-based 3D-QSAR studies on amino derivatives of indole as potent isoprenylcysteine carboxyl methyltransferase (Icmt) inhibitors
Kamlendra Singh Bhadoriya, Mukesh C. Sharma, Shailesh V. Jain
Journal of Molecular Structure, 2015
Structural insights into mode of actions of novel substituted 4- and 6-azaindole-3-carboxamides analogs as renin inhibitors: Molecular modeling studies
Mukesh C. Sharma
Medicinal Chemistry Research, 2015
2,4-Dihydropyrano[2,3-c]pyrazole: Discovery of new lead as through pharmacophore modelling, atom-based 3D-QSAR, virtual screening and docking strategies for improved anti-HIV-1 chemotherapy
Kamlendra Singh Bhadoriya, Mukesh C. Sharma, Shailesh V. Jain
Journal of Taibah University for Science, 2015
Molecular modeling studies on substituted aminopyrimidines derivatives as potential antimalarial compounds
Mukesh C. Sharma, Smita Sharma, K. S. Bhadoriya
Medicinal Chemistry Research, 2015
Molecular modeling studies of thiophenyl C-aryl glucoside sglt2 inhibitors as potential antidiabetic agents
Mukesh C. Sharma, Smita Sharma
International Journal of Medicinal Chemistry, 2014
An approach to design potent anti-Alzheimer's agents by 3D-QSAR studies on fused 5,6-bicyclic heterocycles as γ-secretase modulators using kNN-MFA methodology
Kamlendra Singh Bhadoriya, Mukesh C. Sharma, Smita Sharma, Shailesh V. Jain, Mandar H. Avchar
Arabian Journal of Chemistry, 2014
QSAR studies of some side chain modified 7-chloro-4-aminoquinolines as antimalarial agents
Nitendra K. Sahu, Mukesh C. Sharma, Vishnukanth Mourya, D.V. Kohli
Arabian Journal of Chemistry, 2014
Molecular modelling studies for the discovery of new substituted pyridines derivatives with angiotensin II AT1 receptor antagonists
Mukesh C. Sharma
Interdisciplinary Sciences Computational Life Sciences, 2014
QSAR and pharmacophore approach on substituted imidazole derivatives as angiotensin II receptor antagonists
Mukesh C. Sharma, Smita Sharma, Pratibha Sharma, Ashok Kumar, Kamlendra Singh Bhadoriya
Medicinal Chemistry Research, 2014
Structural requirements of N-aryl-oxazolidinone-5-carboxamide derivatives for anti-HIV protease activity using molecular modelling techniques
Mukesh C. Sharma
Journal of Taibah University for Science, 2014
Discovery of new lead pyrimidines derivatives as potential cannabinoid CB1 receptor antagonistic through molecular modeling and pharmacophore approach
Mukesh C. Sharma
Medicinal Chemistry Research, 2014
Molecular modeling studies of substituted 3,4-dihydroxychalcone derivatives as 5-lipoxygenase and cyclooxygenase inhibitors
Mukesh C. Sharma
Medicinal Chemistry Research, 2014
Densitometric method for the quantification of Melitracen Hydrochloride and Flupentixol Dihydrochloride in pharmaceutical dosage form
World Applied Sciences Journal, 2014
Insight into the structural requirement of substituted quinazolinone biphenyl acylsulfonamides derivatives as Angiotensin II AT1 receptor antagonist: 2D and 3D QSAR approach
Mukesh C. Sharma, D.V. Kohli
Journal of Saudi Chemical Society, 2014
Prediction of potent therapeutic anticonvulsant ligands to N-methyl-d-aspartate receptors among substituted 4,6-dichloroindole-2-carboxylic acids: Molecular modeling approach
Mukesh C. Sharma, Smita Sharma
Journal of Taibah University for Science, 2014
Comparative QSAR and pharmacophore analysis for a series of 2,4-dihydro-3H-1,2,4-triazol-3-ones derivatives as angiotensin II AT1 receptor antagonists
Mukesh C. Sharma, Smita Sharma, Pratibha Sharma, Ashok Kumar, Kamlendra Singh Bhadoriya
Medicinal Chemistry Research, 2014
Pharmacophore and QSAR modeling of some structurally diverse azaaurones derivatives as anti-malarial activity
Mukesh C. Sharma, Smita Sharma, Pratibha Sharma, Ashok Kumar
Medicinal Chemistry Research, 2014
Structural insights for substituted acyl sulfonamides and acyl sulfamides derivatives of imidazole as angiotensin II receptor antagonists using molecular modeling approach
Mukesh C. Sharma, Smita Sharma, Pratibha Sharma, Ashok Kumar, K.S. Bhadoriya
Journal of the Taiwan Institute of Chemical Engineers, 2014
Simultaneous estimation and validation of Alfuzosin hydrochloride in pharmaceutical dosage form by hydrotropic solubilization phenomenon
World Applied Sciences Journal, 2013
Simultaneous estimation and validation of mefenamic acid and drotaverine hydrochloride in tablet dosage form
World Applied Sciences Journal, 2013
Extractive spectrophotometric and liquid chromatographic methods for the determination of rizatriptan in pharmaceutical formulations
Oxidation Communications, 2013
Validated densitometric method for the quantification of mesalamine in pharmaceutical dosage form
World Applied Sciences Journal, 2013
Sensitive spectrophotometric methods for determination of oseltamivir phosphate in pharmaceutical formulation. Comparison with HPLC method
Oxidation Communications, 2013
Development and validation of simplifeid new analytical methods for simultaneous estimation of esomeprazole and domperidone in tablet dosage form
Oxidation Communications, 2013
Simultaneous estimation of nitazoxanide and ofloxacin in dosage form by extractive spectrophotometric method and comparison with liquid chromatographic method
Oxidation Communications, 2013
Comparative QSAR and pharmacophore modeling of substituted 2-[2′-(dimethylamino) ethyl]-1, 2-dihydro-3H-dibenz[de,h]isoquinoline-1,3- diones derivatives as anti-tumor activity
Mukesh C. Sharma, Smita Sharma, Pratibha Sharma, Ashok Kumar
Medicinal Chemistry Research, 2013
Molecular modeling and pharmacophore approach for structural requirements of some 2-substituted-1-naphthols derivatives as potent 5-lipoxygenase inhibitors
Mukesh C. Sharma, Smita Sharma, Pratibha Sharma, Ashok Kumar
Medicinal Chemistry Research, 2013
UV-spectrophotometric method for simultaneous estimation of tenofovir disoproxil fumerate and emtricitabine and its comparison with RP-HPLC and TLC densitometric determination
Oxidation Communications, 2013
UV-spectrophotometric, RP-HPLC and TLC densitometric determination of pseudoephidrine sulphate and desloratidine in pharmaceutical dosage forms
Oxidation Communications, 2013
Application of RP-HPLC and extractive spectrophotometric methods for the determination of lumefantrine in pharmaceutical dosage form
Oxidation Communications, 2013
Extractive spectrophotometric analytical methods for the determination of pioglitazone hydrochloride in pharmaceutical dosage form and its comparison with RP-HPLC and TLC densitometric methods
Oxidation Communications, 2013
Synthesis, docking studies and antioxidant activity of some chalcone and aurone derivatives
Tamanna Narsinghani, Mukesh C. Sharma, Sakshi Bhargav
Medicinal Chemistry Research, 2013
Comprehensive structure-activity relationship analysis of substituted 5-(biphenyl-4-ylmethyl) pyrazoles derivatives as AT1 selective angiotensin II receptor antagonists: 2D and kNNMFA QSAR approach
Mukesh C. Sharma, D. V. Kohli
Medicinal Chemistry Research, 2013
Three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis and molecular docking-based combined in silico rational approach to design potent and novel TRPV1 antagonists
Kamlendra Singh Bhadoriya, Mukesh C. Sharma, Shailesh V. Jain, Ganesh S. Raut, Jyotsna R. Rananaware
Medicinal Chemistry Research, 2013
Quantitative structure-activity relationship analysis of series of substituted piperidin-2-one biphenyl Tetrazoles analogues as novel Angiotensin ii receptor antagonists
Oxidation Communications, 2013
Rationalisation of 2-alkylbenzimidazoles bearing N-Phenylpyrrole moiety as novel angiotensin II at 1 receptor antagonists -A QSAR approach
Oxidation Communications, 2013
3D QSAR kNN-MFA studies on 6-substituted benzimidazoles derivatives as Nonpeptide Angiotensin II Receptor Antagonists: A rational approach to antihypertensive agents
Mukesh C. Sharma, Smita Sharma, Nitendra K. Sahu, D.V. Kohli
Journal of Saudi Chemical Society, 2013
QSAR studies of some substituted imidazolinones angiotensin II receptor antagonists using Partial Least Squares Regression (PLSR) method based feature selection
Mukesh C. Sharma, Smita Sharma, Nitendra K. Sahu, D.V. Kohli
Journal of Saudi Chemical Society, 2013
Comprehensive two and three-dimensional QSAR studies of 3-substituted 6-butyl-1,2dihydropyridin-2-ones derivatives as angiotensin II receptor antagonists
Mukesh C. Sharma, D. V. Kohli
Medicinal Chemistry Research, 2013
Molecular modeling studies of substituted 2,4,5-trisubstituted triazolinones aryl and nonaryl derivatives as angiotensin II ATreceptor antagonists
Mukesh C. Sharma, D. V. Kohli, Smita Sharma
Journal of Chemistry, 2013
A comprehensive structure-activity analysis 2,3,5-trisubstituted 4,5-dihydro-4-oxo-3H-imidazo [4,5-c] pyridine derivatives as angiotensin II receptor antagonists: Using 2D- and 3D-QSAR approach
Mukesh C. Sharma, D. V. Kohli
Medicinal Chemistry Research, 2013
QSAR study of some substituted 4-quinolinyl and 9-acridinyl hydrazones as antimalarial agents
Acta Poloniae Pharmaceutica Drug Research, 2012
QSAR analysis of 2-alkyl-4-(biphenylmethoxy) quinolines as angiotensin II receptor antagonists
Oxidation Communications, 2012
Predicting 2,3-Dihydroquinazolinonesderivatives as angiotensin II receptor antagonists: 2D QSAR approach
Oxidation Communications, 2012
Qsar studies of 2-alkylbenzimidazole derivatives as angiotensin ii receptor antagonists
Oxidation Communications, 2012
Qsar approach insight the structural requirement of substituted quinazolinones derivatives as angiotensin ii receptor antagonists
Oxidation Communications, 2012
Insight into the structural requirement of aryltriazolinone derivatives as angiotensin II AT1 receptor: 2D and 3D-QSAR k-Nearest Neighbor Molecular Field Analysis approach
Mukesh C. Sharma, D. V. Kohli
Medicinal Chemistry Research, 2012
Development and validation of densitometric method for metronidazole and tetracyclinehydrochloride in capsule dosage form
International Journal of Pharmtech Research, 2011
Validated densitometric method for the quantification of lamotrigine in dosage form
International Journal of Pharmtech Research, 2011
Development and validation of TLC densitometric method for gatifloxacin in pharmaceutical formulations
International Journal of Pharmtech Research, 2011
3D QSAR studies of some substituted imidazolinones derivatives angiotensin II receptor antagonists
World Applied Sciences Journal, 2011
Exploration of quantitative structure activity relationship studies on a series of substituted quinazolinones as angiotensin II AT1 receptor antagonists
World Applied Sciences Journal, 2011
Stability and reverse phase HPLC assay method for determination of diacerein and aceclofenac in tablet dosage form - application to dissolution studies
Asian Journal of Pharmaceutical and Clinical Research, 2011
QSAR studies on imidazopyridazine derivatives as PfPK7 inhibitors
Nitendra K. Sahu, Sadhana Shahi, Mukesh C. Sharma, D. V. Kohli
Molecular Simulation, 2011
Spectrophotometric determination of Lamivudine in its bulk and pharmaceutical formulation by hydrotropic solubilization phenomenon
International Journal of Pharmtech Research, 2011
2D QSAR study of 7-methyljuglone derivatives: An approach to design anti tubercular agents
M.C. Sharma, Smita Sharma
Journal of Pharmacology and Toxicology, 2011
Dissolution studies and RP-HPLC method for the simultaneous determination of satranidazole and ofloxacin in pharmaceutical dosage form
International Journal of Chemtech Research, 2011
Spectrophotometric determination of lamivudine in bulk and pharmaceutical formulation using hydrotropic solubilization
International Journal of Chemtech Research, 2011
Isocratic RP-HPLC method for simultaneous estimation of paracetamol and lornoxicam in combined tablet dosage form and its dissolution assessment
International Journal of Chemtech Research, 2011
A facile and isocratic RP-HPLC method and spectroscopy for simultaneous estimation of ramipril in formulation: Dissolution method
International Journal of Chemtech Research, 2011
Stability indicating RP-HPLC method for determination and validation of repaglinide in pharmaceutical dosage form
International Journal of Chemtech Research, 2011
Determination and validation of UV-spectrophotometric method for estimation of paracetamol and diclofenac sodium in tablet dosage forms using hydrotropic solubilizing agents
International Journal of Pharmtech Research, 2011
Spectrophotometric determination and application of hydrotropic solubilization in the quantitative analysis of ranitidine hydrochloride in pharmaceutical dosage form
International Journal of Pharmtech Research, 2011
Reparation, physicochemical characterization, dissolution, formulation and spectroscopic studies of β-cyclodextrins inclusion complex
International Journal of Chemtech Research, 2011
A novel application of simultaneous estimation and validation of nelfinavir mesylate formulations using paracetamol as hydrotropic solubilizing agent in tablet dosage form
International Journal of Chemtech Research, 2011
Micellar liquid chromatographic method development for determination and stability indicating of Nelfinavir Mesylate in pharmaceutical formulation
International Journal of Pharmtech Research, 2011
Forced degradation studies and micellar liquid chromatographic method development for determination of ranitidine hydrochloride in tablet dosage form
International Journal of Chemtech Research, 2011
Enhanced dissolution and spectroscopic analysis studies of the inclusion compound of Nevirapine in β-Cyclodextrin
International Journal of Pharmtech Research, 2011
Design; Synthesis and Antihypertensive activity of 4'-(2-{2-[(2-chloro-benzylidene)-amino]-phenyl}-5-nitro-benzoimidazol-1-ylmethyl)] biphenyl-2-carboxylic acid
International Journal of Advances in Pharmaceutical Sciences, 2010
Synthesis and Biological Evaluation Of Potent Antihypertensive Activity: 2-[(Substituted-phenyl amino)-phenyl-methyl]-1-[2'-(1H-tetrazol-5-Yl) biphenyl-3-ylmethyl]-1H-benzoimidazol-5-ylamine Derivatives
International Journal of Advances in Pharmaceutical Sciences, 2010
A quantitative estimation and validation of Atorvastatin Calcium and Pioglitazone in tablet dosage Form by hydrotropic solubilization phenomenon
International Journal of Pharmtech Research, 2010
Synthesis and Pharmacological evaluation of 4'-[2-(Phenyl-substituted amino-methyl)- benzoimidazol-1-ylmethyl] with Biphenyl Carboxylic acid derivatives as potent antihypertensive agents
International Journal of Pharmtech Research, 2010
Design, Synthesis, and Biological Evaluation of AT1 Angiotensin II Receptor 2 Substituted phenyl- (phenyl-{1- [2-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]- 1H-benzoimidazol-5-ylamine
International Journal of Chemtech Research, 2010
Quantitative structure activity relationship studies of a novel class of dual PPAR γ/δ agonists
International Journal of Pharmtech Research, 2010
Development and validation of an HPTLC method for determination of oseltamivir phosphate in pharmaceutical dosage form
Indian Drugs, 2010
Quantitative structural-activity relationship (QSAR) study for antimycobacterial activities of pyrazine containing thiazoline and thiazolidinone derivatives
Optoelectronics and Advanced Materials Rapid Communications, 2010
Studies on the preparation, characterization, solubility and stability of cefadroxil - β-cyclodextrin inclusion complexes
Journal of Optoelectronics and Advanced Materials, 2010
3D- quantitative structure-activity relationship analysis of some 2-substituted halogenbenzimidazoles analogues with antimycobacterial activity
International Journal of Chemtech Research, 2010
Determination of atorvastatin calcium and pioglitazone HCl in pharmaceutical formulations form by using atomic absorption spectrometry
Optoelectronics and Advanced Materials Rapid Communications, 2010
Development and validation of isocratic reversed-phase HPLC method for simultaneous estimation of torsemide and spironolactone in bulk and pharmaceutical combined tablet dosage form
Optoelectronics and Advanced Materials Rapid Communications, 2010
Formulation and evaluation of analgesic activity, anti-inflammatory and anti-anxiety activity of using plant extracts
Digest Journal of Nanomaterials and Biostructures, 2010
Simultaneous spectroscopic estimation and validation of atorvastatin calcium and pioglitazone in a tablet dosage form
Optoelectronics and Advanced Materials Rapid Communications, 2010
Synthesis and biological activity of 4'-(5-Amino-6-chloro-2-substituted-benzoimidazol-1-ylmethyl)]-biphenyl-2 -carboxylic acid as antihypertensive agents
Digest Journal of Nanomaterials and Biostructures, 2010
In vitro studies of the use of some medicinal herbals leaves against antidepressant, analgesic activity, and anti-inflammatory activity
Digest Journal of Nanomaterials and Biostructures, 2010
Wound healing activity of the Ether-Chloroform extract of momordica charantia fruits s in rats
Digest Journal of Nanomaterials and Biostructures, 2010
Some plant extracts used in pharmacologically activity of anxiolytics, antidepressant, analgesic, and anti-inflammatory activity
Digest Journal of Nanomaterials and Biostructures, 2010
Pharmacological screening effect of ethanolic and methanolic extract of fruits of medicinally leaves
Digest Journal of Nanomaterials and Biostructures, 2010
Simultaneous estimation of rosuvastatin calcium and ezetimibe in tablet dosage form by reverse phase high performance liquid chromatography
Optoelectronics and Advanced Materials Rapid Communications, 2010
Isocratic reverse phase HPLC estimation method of torsemide and spironolactone in pharmaceutical combined dosage form
Optoelectronics and Advanced Materials Rapid Communications, 2010
Combinatorial effect and evaluations of pharmacological, phytochemical studies of combination in three herbal drugs in 95% absolute ethanolic extract
Digest Journal of Nanomaterials and Biostructures, 2010
Pharmacological studies and evaluations of combination in herbal drug leaves and rhizome extracts
Digest Journal of Nanomaterials and Biostructures, 2010
Molecular modelling studies of some substitued 2-butylbenzimidazoles angiotensin II receptor antagonists as antihypertensive agents
Digest Journal of Nanomaterials and Biostructures, 2009
3D- QSAR studies, biological evaluation studies on some substituted 3-Chloro-1-[5-(5-chloro-2-phenyl-benzimidazole-1-ylmethyl)-[1, 3, 4] thiadiazole-2-yl]-azetidin-2-one as potential antimicrobial activity
Digest Journal of Nanomaterials and Biostructures, 2009
Two dimensional-quantitative structure activity relationships -2, 3 diarylthiophenes as selective cox-1/-2 inhibitors
Digest Journal of Nanomaterials and Biostructures, 2009
2D-QSAR studies of some 1, 3, 4-thidiazole-2yl azetidine 2-one as antimicrobial activity
Digest Journal of Nanomaterials and Biostructures, 2009
QSAR, synthesis and biological activity studies of some thiazolidinones derivatives
Digest Journal of Nanomaterials and Biostructures, 2009
Synthesis, characterization and biological activities of some 1-(nicotinylamino) -2 substituted azetidine-4 -ones as potential antibacterial agents
Digest Journal of Nanomaterials and Biostructures, 2009

Dr Mukesh Chandra SHarma

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Scopus Publications