Maheep Kumar

@gpgc.obra.ac.in

Assistant Professor Department of Botany, Government Post Graduate College Obra Sonebhadra
Government Post Graduate College Obra Sonebhadra

Maheep Kumar


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https://researchid.co/maheep.bot

EDUCATION

Botany) 2013 from Banaras Hindu University, Varanasi

RESEARCH, TEACHING, or OTHER INTERESTS

Microbiology, Nature and Landscape Conservation, Drug Discovery, Molecular Biology
4

Scopus Publications

Scopus Publications

  • Lyngbya sp.: A suitable cyanobacterium for harvesting antimicrobial compounds
    Asian Journal of Pharmaceutical and Clinical Research, 2014
  • Harvesting of valuable eno- and exo-metabolites form cyanobacteria: A potential source
    Asian Journal of Pharmaceutical and Clinical Research, 2014
  • Identification and structure elucidation of antimicrobial compounds from Lyngbya aestuarii and Aphanothece bullosa
    Cellular and Molecular Biology, 2014
  • Cyanobacteria, Lyngbya aestuarii and Aphanothece bullosa as antifungal and antileishmanial drug resources
    Maheep Kumar, Manoj Kumar Tripathi, Akanksha Srivastava, Jalaj Kumar Gour, Rakesh Kumar Singh, Ragini Tilak, Ravi Kumar Asthana
    Asian Pacific Journal of Tropical Biomedicine, 2013
    OBJECTIVE: To investigate two cyanobacteria isolated from different origins i.e. Lyngbya aestuarii (L. aestuarii) from brackish water and Aphanothece bullosa (A. bullosa) from fresh water paddy fields for antifungal and antileishmanila activity taking Candida albicans and Leishmania donovain as targets. METHODS: Biomass of L. aestuarii and A. bullosa were harvested after 40 and 60 d respectively and lyophilized twice in methanol (100%) and redissolved in methanol (5%) for bioassay. Antifungal bioassay was done by agar well diffusion method while antileishmanial, by counting cell numbers and flageller motility observation of promastigotes and amastigotes from L. donovani. Fluconazole and 5% methanol were used as control. RESULTS: Both the cyanobacteria were found to be potent source of antifungal activity keeping fluconazole as positive control, however, methanolic crude extract (15 mg/mL) of A. bullosa was found more potent (larger inhibition zone) over that of methanolic crude extract of L. aestuarii. Similarly antileishmanial activity of crude extract (24.0 mg/mL) of A. bullosa was superior over that of methanolic crude extract of L. aestuarii (25.6 mg/mL). CONCLUSIONS: Antifungal and antileishmanial drugs are still limited in the market. Screening of microbes possessing antifungal and antileishmanial activity drug is of prime importance. Cyanobacteria are little explored in this context because most of the drugs in human therapy are derived from microorganisms, mainly bacterial, fungal and actinomycetes. Thus in the present study two cyanobacterial strains from different origins showed potent source of antifungal and antileishmanial biomolecules.