Luana dos Santos Ortolan

@seattlechildrens.org

Research Scientist III at Center for Global and Infectious Disease
Seattle Children's Research Institute

Luana dos Santos Ortolan


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https://researchid.co/luanaortolan

RESEARCH, TEACHING, or OTHER INTERESTS

Infectious Diseases, Immunology and Microbiology, Neuroscience
417

Scholar Citations

10

Scholar h-index

11

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • T H 1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata
    SJ Connell, S Crotts, R Reis, MM Lensing, P Kahl, N Henderson, O Ayush, ...
    Science advances 11 (44), eadz2257 , 2025
    2025
    Citations: 1
  • Nilotinib attenuates vascular pathology in experimental cerebral malaria
    LS Ortolan, P Bansal, VI Primavera, RJRX Freitas, L Wei, S Epiphanio, ...
    Blood Advances 9 (10), 2473-2488 , 2025
    2025
    Citations: 3
  • Single-cell analysis of Sézary syndrome reveals novel markers and shifting gene profiles associated with treatment
    N Borcherding, KJ Severson, N Henderson, LS Ortolan, AC Rosenthal, ...
    Blood advances 7 (3), 321-335 , 2023
    2023
    Citations: 32
  • Blockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mice
    MK Sercundes, LS Ortolan, V da Silva Julio, LM Bella, T de Castro Quirino, ...
    Cell Death & Disease 13 (2), 144 , 2022
    2022
    Citations: 11
  • Plasmodium falciparum Parasite Lines Expressing DC8 and Group A PfEMP1 Bind to Brain, Intestinal, and Kidney Endothelial Cells
    LS Ortolan, M Avril, J Xue, KB Seydel, Y Zheng, JD Smith
    Frontiers in Cellular and Infection Microbiology 12, 813011 , 2022
    2022
    Citations: 17
  • CD4 T cell-mediated induction of alopecia areata is dose dependent and requires CD8 T cells
    SJ Connell, S Crotts, P Christy, L Ortolan, N Henderson, A Jabbari
    The Journal of Immunology 206 (1_Supplement), 21.14-21.14 , 2021
    2021
    Citations: 2
  • 020 Induction of hair loss by expanded CD4 T cells from previously affected AA mice
    SJ Connell, S Crotts, P Christy, L Ortolan, N Henderson, A Jabbari
    Journal of Investigative Dermatology 141 (5), S4 , 2021
    2021
  • 070 Comprehensive single-cell analysis of Sézary syndrome reveals novel expression and therapeutic biomarkers
    N Borcherding, N Henderson, L Ortolan, V Liu, B Link, A Mangold, ...
    Journal of Investigative Dermatology 141 (5), S12 , 2021
    2021
  • Perillyl alcohol reduces parasite sequestration and cerebrovascular dysfunction during experimental cerebral malaria
    AA Marin, O Murillo, RA Sussmann, LS Ortolan, DS Battagello, ...
    Antimicrobial Agents and Chemotherapy 65 (5), 10.1128/aac. 00004-21 , 2021
    2021
    Citations: 9
  • Comprehensive Single-Cell Analysis of Peripheral Blood in Sezary Syndrome Reveals Novel Expression Markers and Shifting Gene Profiles Associated with Treatment
    N Borcherding, N Henderson, L Ortolan, V Liu, B Link, A Mangold, ...
    LABORATORY INVESTIGATION 101 (SUPPL 1), 287-287 , 2021
    2021
  • Perillyl alcohol reduces parasite sequestration and cerebrovascular dysfunction during experimental cerebral malaria
    AAM Rodriguez, O Murillo, RAC Sussmann, LS Ortolan, DS Battagello, ...
    Antimicrobial Agents and Chemotherapy 65 (5), 1-14 , 2021
    2021
  • Single-Cell mRNA Sequencing of Murine and Human Alopecia Areata Identifies Immune Cell Profiles Predictive of Human Disease State
    N Borcherding, S Crotts, L Ortolan, N Bormann, A Jabbari
    American Journal of Clinical Pathology 154, S5 , 2020
    2020
  • A transcriptomic map of murine and human alopecia areata
    N Borcherding, SB Crotts, LS Ortolan, N Henderson, NL Bormann, ...
    JCI insight 5 (13), e137424 , 2020
    2020
    Citations: 40
  • Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis
    TC Quirino, LS Ortolan, MK Sercundes, CRF Marinho, WM Turato, ...
    Plos one 15 (5), e0233864 , 2020
    2020
    Citations: 5
  • Endothelial protein C receptor contributes to experimental malaria-associated acute respiratory distress syndrome
    L Ortolan, M Sercundes, G Moura, T Quirino, D Debone, D Costa, ...
    EUROPEAN JOURNAL OF IMMUNOLOGY 49, 1204-1204 , 2019
    2019
  • IL-12/IL-23 neutralization is ineffective for alopecia areata in mice and humans
    LS Ortolan, SR Kim, S Crotts, LY Liu, BG Craiglow, C Wambier, ...
    The Journal of allergy and clinical immunology 144 (6), 1731 , 2019
    2019
    Citations: 34
  • 105 Neutralization of IL-12 and IL-23 does not prevent experimental alopecia areata
    L Ortolan, S Crotts, A Jabbari
    Journal of investigative dermatology 139 (5), S18 , 2019
    2019
  • 099 CD4 T cells require CD8 T cells to induce disease in murine alopecia areata
    S Crotts, L Ortolan, A Jabbari
    Journal of investigative dermatology 139 (5), S17 , 2019
    2019
  • Research Article Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome
    L dos Santos Ortolan, MK Sercundes, GC Moura, T de Castro Quirino, ...
    2019
  • Endothelial Protein C Receptor Could Contribute to Experimental Malaria‐Associated Acute Respiratory Distress Syndrome
    L dos Santos Ortolan, MK Sercundes, GC Moura, T de Castro Quirino, ...
    Journal of Immunology Research 2019 (1), 3105817 , 2019
    2019
    Citations: 11

MOST CITED SCHOLAR PUBLICATIONS

  • Targeting neutrophils to prevent malaria-associated acute lung injury/acute respiratory distress syndrome in mice
    MK Sercundes, LS Ortolan, D Debone, PV Soeiro-Pereira, E Gomes, ...
    PLoS pathogens 12 (12), e1006054 , 2016
    2016
    Citations: 131
  • Association of heme oxygenase 1 with lung protection in malaria‐associated ALI/ARDS
    MLM Pereira, LS Ortolan, MK Sercundes, D Debone, O Murillo, FA Lima, ...
    Mediators of Inflammation 2016 (1), 4158698 , 2016
    2016
    Citations: 43
  • A transcriptomic map of murine and human alopecia areata
    N Borcherding, SB Crotts, LS Ortolan, N Henderson, NL Bormann, ...
    JCI insight 5 (13), e137424 , 2020
    2020
    Citations: 40
  • Predictive Criteria to Study the Pathogenesis of Malaria‐Associated ALI/ARDS in Mice
    LS Ortolan, MK Sercundes, R Barboza, D Debone, O Murillo, SCF Hagen, ...
    Mediators of Inflammation 2014 (1), 872464 , 2014
    2014
    Citations: 38
  • IL-12/IL-23 neutralization is ineffective for alopecia areata in mice and humans
    LS Ortolan, SR Kim, S Crotts, LY Liu, BG Craiglow, C Wambier, ...
    The Journal of allergy and clinical immunology 144 (6), 1731 , 2019
    2019
    Citations: 34
  • Single-cell analysis of Sézary syndrome reveals novel markers and shifting gene profiles associated with treatment
    N Borcherding, KJ Severson, N Henderson, LS Ortolan, AC Rosenthal, ...
    Blood advances 7 (3), 321-335 , 2023
    2023
    Citations: 32
  • Plasmodium falciparum Parasite Lines Expressing DC8 and Group A PfEMP1 Bind to Brain, Intestinal, and Kidney Endothelial Cells
    LS Ortolan, M Avril, J Xue, KB Seydel, Y Zheng, JD Smith
    Frontiers in Cellular and Infection Microbiology 12, 813011 , 2022
    2022
    Citations: 17
  • Blockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mice
    MK Sercundes, LS Ortolan, V da Silva Julio, LM Bella, T de Castro Quirino, ...
    Cell Death & Disease 13 (2), 144 , 2022
    2022
    Citations: 11
  • Endothelial Protein C Receptor Could Contribute to Experimental Malaria‐Associated Acute Respiratory Distress Syndrome
    L dos Santos Ortolan, MK Sercundes, GC Moura, T de Castro Quirino, ...
    Journal of Immunology Research 2019 (1), 3105817 , 2019
    2019
    Citations: 11
  • Inhibition of hypoxia‐associated response and kynurenine production in response to hyperbaric oxygen as mechanisms involved in protection against experimental cerebral malaria
    MF Bastos, ACAV Kayano, JL Silva‐Filho, JCK Dos‐Santos, C Judice, ...
    The FASEB Journal 32 (8), 4470-4481 , 2018
    2018
    Citations: 11
  • Survey of Plasmodium in the golden-headed lion tamarin ( Leontopithecus chrysomelas ) living in urban Atlantic forest in Rio de Janeiro, Brazil
    EH Aitken, MG Bueno, L dos Santos Ortolan, JM Alvaréz, A Pissinatti, ...
    Malaria Journal 15 (1), 93 , 2016
    2016
    Citations: 10
  • Perillyl alcohol reduces parasite sequestration and cerebrovascular dysfunction during experimental cerebral malaria
    AA Marin, O Murillo, RA Sussmann, LS Ortolan, DS Battagello, ...
    Antimicrobial Agents and Chemotherapy 65 (5), 10.1128/aac. 00004-21 , 2021
    2021
    Citations: 9
  • Physiopathology of malaria-associated acute respiratory distress syndrome
    G Candido Moura, D Barcelos, S Epiphanio, LD Santos Ortolan
    J Infect Dis Preve Med 5 (171), 2 , 2017
    2017
    Citations: 9
  • Correction: targeting neutrophils to prevent malaria-associated acute lung injury/acute respiratory distress syndrome in mice
    MK Sercundes, LS Ortolan, D Debone, PV Soeiro-Pereira, E Gomes, ...
    PLoS pathogens 13 (11), e1006730 , 2017
    2017
    Citations: 7
  • Lung aeration in experimental malaria-associated acute respiratory distress syndrome by SPECT/CT analysis
    TC Quirino, LS Ortolan, MK Sercundes, CRF Marinho, WM Turato, ...
    Plos one 15 (5), e0233864 , 2020
    2020
    Citations: 5
  • Nilotinib attenuates vascular pathology in experimental cerebral malaria
    LS Ortolan, P Bansal, VI Primavera, RJRX Freitas, L Wei, S Epiphanio, ...
    Blood Advances 9 (10), 2473-2488 , 2025
    2025
    Citations: 3
  • CD4 T cell-mediated induction of alopecia areata is dose dependent and requires CD8 T cells
    SJ Connell, S Crotts, P Christy, L Ortolan, N Henderson, A Jabbari
    The Journal of Immunology 206 (1_Supplement), 21.14-21.14 , 2021
    2021
    Citations: 2
  • Inflammatory factors and leucocytes are involved in the pathogenesis of malaria associated acute lung injury/acute respiratory distress syndrome in murine model
    MK Sercundes, LD Ortolan, D Debone, EH Aitken, JM Alvarez, M Russo, ...
    Front Immunol 4 , 2013
    2013
    Citations: 2
  • T H 1 effector CD4 T cells rely on IFN-γ production to induce alopecia areata
    SJ Connell, S Crotts, R Reis, MM Lensing, P Kahl, N Henderson, O Ayush, ...
    Science advances 11 (44), eadz2257 , 2025
    2025
    Citations: 1
  • Citoadesão na imunopatogênese da síndrome do desconforto respiratório agudo associado à malária.
    LS Ortolan
    Universidade de São Paulo , 2017
    2017
    Citations: 1