Cancer Research, Organic Chemistry, Drug Discovery, Pharmaceutical Science
206
Scopus Publications
11073
Scholar Citations
53
Scholar h-index
147
Scholar i10-index
Scopus Publications
Triazines as Versatile Scaffolds in Drug Discovery: A Comprehensive Review on Recent Advances and Emerging Therapeutic Applications Mohd Shafeeque, Shaikh Yahya, Akram Choudhary, Nisha Vats, Kashif Haider, S. Salahuddin, M. Shahar Yar Current Organic Chemistry, 2026 Triazine is a heterocyclic aromatic ring that is divided into three isomers by nitrogen atom positions. 2-Aza-2-desamino-5,8-dideazafolic acid and 2-azaadenosine are 1,2,3-triazine derivatives, whereas azaribine, tirapazamine, lamotrigine, and 6-azacytosine are 1,2,4-triazine derivatives. Natural antibiotics like fervenulin, reumycin, and toxoflavin have a triazine ring structure. Ammeline, aceto-guanide, acetoguanamine, cyanuric acid, and melamine all include 1,3,5-triazine isomer or s-triazine as a lead structure. Hexamethylmelamine (altretamine), atrazine, cycloguanil, and almitrine are examples of s-triazine-containing medications. Triazines are important in pharmaceutical chemistry because they exhibit a wide range of pharmacological actions, making them valuable for drug design and development. Some triazine analogs have recently been tested in clinical trials, which might lead to more powerful medications and have fewer adverse effects than currently available pharmaceuticals. This article discusses the biological significance and synthesis of several triazine derivatives derived from heterocyclic and Triazine-containing medicines.
Advances in the Synthesis and Therapeutic Exploration of Pyrazole/Pyrazoline- Bearing Benzimidazoles: Searching for New Lead Compounds Sapna Rani, Salahuddin, Avijit Mazumder, Rajnish Kumar, Saloni Mangal, Vimal Datt, Mohamed Jawed Ahsan, Mohammad Shahar Yar Current Organic Chemistry, 2026 This comprehensive review outlines the multifaceted applications of pyrazolines and benzimidazoles, encompassing their discovery, synthetic methodologies, patent landscape, and clinical trial outcomes, with a focus on pyrazoline-benzimidazole or pyrazole-benzimidazole derivatives. This review highlights the synthesis and biological evaluation of pyrazoline-bearing benzimidazoles obtained through the reaction of benzimidazoles with substituted pyrazolines/pyrazoles. The synthesized compounds demonstrated a broad spectrum of pharmacological activities, including antimicrobial, antibacterial, antitubercular, antimalarial, anthelmintic, antiproliferative, anticancer, antinociceptive, antihistaminic, antiulcer, etc. Research on pyrazoline and benzimidazole derivatives constitutes a dynamic field, expanding the research domain within pharmaceutical chemistry and offering potential therapeutic solutions for various diseases.
An Insight Into Commercially Available SGLT2 Inhibitors and Their Structure–Activity Relationship Studies Asiya Parveen, Shazia Parveen, Nisha Vats, Mohd. Shafeeque, Akram Choudhary, Syed Ali Hasnain Zaidi, M. Shahar Yar Archiv Der Pharmazie, 2025 A serious, rapidly growing global health issue is diabetes mellitus (Type 2) caused by insulin deficiency or insulin resistance. This is a chronic condition that demands ongoing care and management. Although a variety of anti‐hyperglycaemic medications are available, the need for safer, more effective, and affordable antidiabetic treatments remains crucial due to the undesirable side effects associated with existing options. This review primarily highlights the innovative sodium‐glucose co‐transporter 2 (SGLT‐2) inhibitors and explores their various characteristics. Gliflozins represent an important class of medications used to manage type II diabetes by targeting the SGLT2. By inhibiting SGLT2, they effectively reduce blood glucose levels by preventing the kidneys from reabsorbing glucose. This review offers a comprehensive overview of gliflozins approved by leading regulatory authorities such as the Food and Drug Administration (FDA), European Medicines Agency (EMA), and Pharmaceuticals and Medical Devices Agency (PMDA). It explores the design and development of sodium‐glucose co‐transporter (SGLT) inhibitors, their mechanisms of action, structure–activity relationships, and additional therapeutic applications.
Exploration of Glitazone/Thiazolidinedione Derivatives: Molecular Design and Therapeutic Potential Salahuddin, Avijit Mazumder, Mohamed Jawed Ahsan, Rajnish Kumar, Zabih Ullah, Mohammad Shahar Yar, Km Shabana Bioengineering, 2025 This review of thiazolidinedione or glitazone, which have a five-membered heterocyclic ring C3NS, shows their versatile properties in terms of pharmacological actions such as antimicrobial, antifungal, insecticidal, pesticidal, antidiabetic, anti-inflammatory, anti-proliferative, anti-neurotoxicity, anticonvulsant, anti-thyroidal, and anti-tubercular uses. While having a wide range of biological activities, the TZDs mainly act via binding to the peroxisome proliferator-activated receptor (PPAR) members. PPAR-γ are ligand-activated transcription factors, which are members of the nuclear hormone receptors group. Activations of PPAR-γ regulate cell proliferation and differentiation, glucose homeostasis, apoptosis, lipid metabolism, and inflammatory responses. This review explores the synthesis of a thiazolidinedione and its derivatives, focusing on their pharmacological profiles and antidiabetic activity. It highlights the benefits of synthesis, reaction profiles, and catalyst recovery, which may encourage further investigation into these scaffolds by researchers. Based on synthesized derivatives, some glimpses of the structure–activity relationships of some compounds have been compiled. All the synthesized derivatives have been reviewed concerning their standard drugs already available and concluded with the highly or moderately active synthesized derivatives of thiazolidinedione. The data for this review was collected by an extensive review of current scientific literature, including on the synthesis, biological evaluation, SAR, and patents (2015–25).
Synthetic Strategies and SAR Studies of Triazine-Based Antiepileptic Agents: A Bench to Bedside Approach Nisha Vats, Asiya Parveen, Mohd Shafeeque, Akram Choudhary, Shaikh Yahya, M. Shahar Yar Archiv Der Pharmazie, 2025 Due to their strong biological activity, heterocyclic compounds containing triazine scaffolds are now of interest to a large number of organic chemists. It has been discovered that the triazine ring possesses antiepileptic properties. The article's goal is to highlight these particular ring diversities of study using triazine moieties that include medications and patent numbers. A variety of antiepileptic medications are being developed and will soon be available in the market to treat aberrant neuronal excitability. Among the key objectives to deal with a number of disorders affecting the central nervous system, such as epilepsy, chronic pain, mental illnesses, and spasticity, are voltage‐gated sodium channel blockers. By blocking intricate voltage and frequency‐dependent ionic currents via sodium channels, they prevent seizures. Although the sodium channel has been arguably the most extensively researched target for seizure control or treatment over the last 10 years, no ground‐breaking findings have been made as of yet. Despite the fact that several medications are licensed to treat epilepsy, they are linked to a range of acute and long‐term adverse effects. To treat epileptic seizures, multiple teams of researchers have been working nonstop to develop improved therapeutic medications for this well‐liked target. The evolution of authorized sodium channel blockers as anticonvulsant medications is briefly noted in the study. To reduce the toxicity, medicinal chemists have attempted to create several stronger anticonvulsant medications, which are covered below. Their potential mechanism and structure–activity relationship (SAR) is highlighted.
A Comprehensive Review of Lavandula stoechas L. (Ustukhuddus) Plant: Phytochemistry, Pharmacology, and In Silico Studies Rizwan Ahamad, Satendra Kumar, Mohd. Akhtar, Mohd. Aqil, Mohammad Shahar Yar, Mohd. Akram, Mohd. Vaseem Ismail, Mohd. Mujeeb Chemistry and Biodiversity, 2025 Lavandula stoechas L., also referred to as French lavender or Spanish lavender, is a well‐known medicinal plant with a strong presence in traditional medicine systems. This review provides an overview of the existing research progress on L. stoechas, encompassing its traditional uses, medicinal phytochemistry, pharmacological activity as well as clinical applications, and in silico studies. Literature searches on the traditional, medicinal phytochemistry and biological activities of L. stoechas were conducted using online databases that included Web of Science, Google Scholar, Scopus, ScienceDirect, and PubMed as well as pre‐electronic literature sources obtained from the library of the university. Recent scientific studies have explored the phytochemicals of L. stoechas, revealing a diverse collection of bioactive substances, including flavonoids, terpenes, and phenolic acids. Pharmacological studies have provided additional clarity on the therapeutic benefits of extracts and isolated components from L. stoechas. Studies confirm its antibacterial, anti‐inflammatory, antioxidant, and neuroprotective effects and its potential for anxiety, insomnia, and dermatological disorders. Computational approaches revealed ligand interactions between L. stoechas constituents and targets, enhancing understanding through in silico analysis. In summary, the combined study underscores L. stoechas’s diverse therapeutic potential, validating its traditional uses while providing scientific insights into its chemical composition, its formulations, its molecular mechanisms, and its pharmacological activities.
Development, Characterization, and Anti-Aging Potential of Fish Collagen Peptide-Based Beverages with Bovine Colostrum Fawze Alnadari, Ge Cheng, Rongchang Wang, Chao Chen, Mustapha Nasiru, et al. Iranian Journal of Chemistry and Chemical Engineering, 2025 This study aims to formulate, evaluate, develop, and characterize Fish Collagen Peptide-Based Beverages (FCPB) supplemented with bioactive compounds, including Transforming Growth Factor-beta (TGF-β), from Bovine Colostrum (BC) in varying concentrations (0-4%) to enhance health benefits. Incorporating BC into FCPB beverages (FCPB- BC) improved their physicochemical properties, characteristics, and antioxidant levels. The resulting FCPB-BC beverages exhibited desirable physicochemical properties, antioxidant activity, and stability. The physicochemical, microbiological, and sensory properties of pasteurized FCPB-BC were evaluated over a storage period of 28 days at elevated temperatures (37°C). Remarkably, the shelf-life of these beverages extended to one year, ensuring prolonged preservation of their enhanced properties. Notably, the conversion ratio of 0.16 g BC into FCPB beverages (FCPB-BC2) demonstrated superior stability and benefits compared to the higher concentrations of 0.24 g (FCPB-BC3) and 0.32 g (FCPB-BC4), where protein precipitation was observed. Specifically, FCPB-BC2 showed consistent sensor readings with the E-Nose, maintaining stable values over time, such as 1.075 (week 1), 0.983 (week 2), and 0.973 (week 4) for W1C, and 0.828 (week 1) to 1.468 (week 4) for W5S, indicating superior sensory consistency. In contrast, FCPB-BC3 and FCPB-BC4 exhibited greater fluctuations in sensor responses, such as 0.887 (week 1) to 1.164 (week 4) for W1S in FCPB-BC3 and 1.164 (week 1) to 1.288 (week 3) for W1S in FCPB-BC4. These findings support the conclusion that FCPB-BC2 is the optimal formulation, offering the best stability and promising health benefits for future development. Additionally, efficacy assessment demonstrated significant improvements in skin characteristics, including elasticity and hydration of the stratum corneum, after 28 days of application. Wrinkle characteristics, such as surface roughness and volume, were markedly reduced, with improved skin appearance, elasticity, firmness, and hydration. The FCPB-BC beverages offer a natural and safe alternative for those searching for non-invasive anti-aging remedies.
Synthesis and Evaluation of Antidiabetic Potential of Gliptin-based Hybrid Scaffolds Shaikh Yahya, Vivek Kumar Gour, Jaiprakash Sangshetti, Prathamesh Deshpande, Mohd Shafeeque, Nisha Sharma, Akram Choudhary, M Shahar Yar Chemistry and Biodiversity, 2025 Dipeptidyl peptidase‐4 (DPP4) inhibitors are promising therapeutic targets for the treatment of a catastrophic disease, especially diabetes mellitus (DM), which contributed to a massive rate of mortality. This research work succinctly covers the significance and vital role of gliptins in diabetes management and in the potential areas of further antidiabetic research, making it a strong drug candidate for antidiabetic drug development. We illustrated herein molecular docking, synthesis, and biological evaluation of selected potent synthesized molecules. Additionally, all the potent compounds were characterized by means of MASS and NMR spectral analysis, whereas the purity of these molecules were assessed by HPLC method. In order to determine the efficacy and cytotoxicity of synthesized gliptin‐based scaffolds, in‐vitro anti‐oxidant and MTT assays with the implantation of DPPH and THP‐1 cell lines, respectively, were performed. The results data disclose the anti‐oxidant and biosafety potential of the newly schemed compounds. Based on in‐vitro screening outcomes, only a derivative that exhibited potent efficacy was selected and subjected to an in‐vivo study. Among them, compounds 6 and 12 are the most potent ones, which exhibited % radical scavenge of 89.38 % and 91.58 % related to standard ascorbic acid (91.58 %). Surprisingly, these compounds also exhibited excellent anti‐diabetic efficacy at a dose of 4 mg/kg in an in‐vivo animal model. In conclusion, all studies suggested that the titled molecules could be promising lead compounds for the treatment of patients with type 2 diabetes mellitus.
Synthesis, Anticonvulsant, and Molecular Docking Studies of 2-(2-Benzyl-1Hbenzo[ d]imidazol-1-yl)-1-(3,5-disubstituted phenyl)-4,5-dihydro-1H-pyrazol-1-yl) ethan-1-ones Indian Journal of Heterocyclic Chemistry, 2022
Synthesis and Pharmacological Evaluation of Some New (1H-Benzimidazol-2-yl)-substituted Methyl-1-(6-substituted-2-chloroquinolin-3-yl)Methanimines Indian Journal of Heterocyclic Chemistry, 2022
Synthesis, Characterization, and Antidiabetic Evaluation of Substituted 5-(2-Chloro-Quinolin-3-Ylmethylene)-Thiazolidine-2,4-Dione Indian Journal of Heterocyclic Chemistry, 2021
Synthesis, antimicrobial, and molecular docking studies of 1,3-Thiazolidin-4-one analogs bearing benzothiazole Indian Journal of Heterocyclic Chemistry, 2020
Synthesis and anticonvulsant activity of a combined pharmacophore of 2-oxo-1,2-dihydroquinoline containing 1,3,4-oxadiazole derivatives Indian Journal of Heterocyclic Chemistry, 2017
Synthesis, characterization and biological evaluation of novel 1,2,4-triazole derivatives as potent antibacterial and anti-inflammatory agents Der Pharma Chemica, 2014
Triazole as pharmaceuticals potentials International Journal of Pharmtech Research, 2013
Microwave assisted one pot synthesis of some pyrazole derivatives as a safer anti-inflammatory and analgesic agents Acta Poloniae Pharmaceutica Drug Research, 2013
Synthesis and antihyperglycemic activity of 2-(substituted phenyl)-3-{[4-(1-naphthyl)-1,3-thiazol-2-yl] amino}-4-oxo-1, 3- thiazolidin-5-ylacetic acid derivatives Acta Poloniae Pharmaceutica Drug Research, 2009
Synthesis, characterization and antimicrobial evaluation of novel imines and thiazolidinones Acta Poloniae Pharmaceutica Drug Research, 2009
2(3H)-furanones AND 2(3H)-pyrrolones: Synthesis and antimycobacterial evaluation Acta Poloniae Pharmaceutica Drug Research, 2009
Design, synthesis and biological evaluation of 1,3,4-oxadiazole derivatives Asian Journal of Chemistry, 2009
Microwave assisted synthesis, characterization and pharmacological evaluation of pyridazinone derivatives Asian Journal of Chemistry, 2009
Synthesis, characterization and biological studies of novel imines and azetidinones derivatives of haloaryloxy moiety Asian Journal of Chemistry, 2008
Synthesis, characterization and biological studies of new Schiff bases and azetidinones derived from propionic acid derivatives Asian Journal of Chemistry, 2008
Synthesis of novel substituted pyrazolyl-2-toluidinomethanethione and pyrazolyl-2-methoxyanilinomethanethione as potential antitubercular agents Acta Poloniae Pharmaceutica Drug Research, 2007
Synthesis and in-vitro antimycobacterial activity of amino-5-[(substituted) phenyl]-3-(4-hydroxy-3-methylphenyl)-4,5-dihydro-1H-1-pyrazolylmethanethione Acta Poloniae Pharmaceutica Drug Research, 2007
Synthesis and anti-HIV activity of N1-nicotinoyl - 3-(4′-hydroxy-3′-methylphenyl)-5-[substituted phenyl] - 2-pyrazolines Acta Poloniae Pharmaceutica Drug Research, 2007
An overview of patents Biosciences Biotechnology Research Asia, 2006
Synthesis and antimicrobial activity of 3-(4′-hydroxy-3′- methylphenyl)-5-[(substuted) phenyl]-4,5-dihydro-1H-1-pyrazolyl-4- pyridylmethanone derivatives Acta Poloniae Pharmaceutica Drug Research, 2006
Clinical trial: The most critical step in the process of drug development Biosciences Biotechnology Research Asia, 2006
Synthesis and antibacterial activity of epoxides derived from chalcones Asian Journal of Chemistry, 2005
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Recent Trends in the Synthesis of Benzimidazoles and Use of the Phillips Modification. A Review S Rani, Salahuddin, A Mazumder, R Kumar, S Mangal, R Sharma, ... Organic Preparations and Procedures International, 1-30 , 2026 2026
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Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities J Akhtar, AA Khan, Z Ali, R Haider, MS Yar European journal of medicinal chemistry 125, 143-189 , 2017 2017 Citations: 581
Ciprofloxacin: review on developments in synthetic, analytical, and medicinal aspects PC Sharma, A Jain, S Jain, R Pahwa, MS Yar Journal of enzyme inhibition and medicinal chemistry 25 (4), 577-589 , 2010 2010 Citations: 451
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