Dr. Hem Ch. Joshi serves as an Assistant Professor in the Department of Botany at D.S.B. Campus, Kumaun University, situated in Nainital, Uttarakhand, India. He holds a Ph.D. in Plant Physiology, which he earned from the prestigious G.B. Pant University of Agriculture and Technology in Pantnagar, Uttarakhand. For the past 8 years, Dr. Joshi has been actively engaged in research, focusing on several fascinating areas such as Environmental Nanotechnology, Bio-Nanotechnology, Plant Physiology, Mineral Nutrition, and Biosensors. His research work has earned him a noteworthy h-index of 7, signifying the impact of his scholarly contributions. Throughout his career, Dr. Joshi's dedication to advancing scientific knowledge is evident through his 30 peer-reviewed research articles published in reputed international journals. He also shares his findings with the academic community by presenting his research in over 20 international and national conferences.
EDUCATION
B.Sc. Kumaun University Zoology, Botany, Chemistry 2010
M.Sc. G.B.P.U.A. & T. Pantnagar Biophysics, Molecular Biology, Biochemistry, Cell Biology 2013
M.Sc. Uttarakhand Open University Botany 2021
Ph.D. G.B.P.U.A. & T. Pantnagar Plant Physiology 2019
RESEARCH, TEACHING, or OTHER INTERESTS
Agricultural and Biological Sciences, Plant Science, Agronomy and Crop Science, Biophysics
12
Scopus Publications
618
Scholar Citations
9
Scholar h-index
8
Scholar i10-index
Scopus Publications
Green Nanotechnology for the Management of Lung Cancer Swati Joshi, Hem C. Joshi, Saurabh Gangola Nanotechnology and Drug Delivery Innovations in Lung Cancer Treatment, 2026 Lung cancer is one of the leading causes of cancer deaths across the globe, thus demanding new techniques for effective diagnosis and management of this disease. In this context, green nanotechnology has emerged as a promising approach capable of utilizing the principles of sustainability to produce nanomaterials for potential application in lung cancer management. Green nanotechnology has the potential to revolutionize conventional cancer therapy practices with its environment friendly and biocompatible properties. Green nanoparticles have unique properties, including high surface area, tunable size, and multifunctionality, which render them suitable for targeted drug delivery, imaging, and therapeutic interventions into lung cancer. The chapter examines the working mechanism by which green nanoparticles enhance drug bioavailability, reduce systemic toxicity, and combat multi drug resistance. In addition, the discussion of green nanotechnology is extended to its incorporation with advanced treatment methods such as photothermal therapy and immunotherapy to show its synergistic effect. In this regard case studies and the recent results obtained in the field of preclinical and clinical application are considered to present the practical advantages and obstacles of these environmentally friendly nanostructures. This chapter also explains the environmental and regulatory measures of green nanotechnology and its significance in the pursuit of sustainable development goals while fostering the advancement of medicine and also addressing the intersection of green chemistry and oncology.
Revolutionizing drug discovery: Cutting-edge innovations in mass spectrometry Hem Ch. Joshi, Prabha Pant, Harsh Kumar Chauhan, Anil Verma Modern Spectroscopic Techniques for Drug Discovery and Environmental Sustainability, 2025 Mass spectrometry (MS) has revolutionized drug discovery, offering unparalleled accuracy in identifying and quantifying biomolecules. Recent advancements, such as high-resolution MS, have enhanced sensitivity and resolution, enabling precise molecular characterization. Techniques like liquid chromatography-MS (LC-MS) and quantitative MS, including multiple reaction monitoring (MRM), have improved drug metabolism and pharmacokinetics studies. Imaging mass spectrometry (IMS) allows for the spatial visualization of drug distribution in tissues, providing insights into drug efficacy and safety. These innovations accelerate the identification of drug candidates and their mechanisms, transforming pharmaceutical research and personalized medicine development.
Nanotheranostics for Chronic Obstructive Pulmonary Disease (COPD): Status and Implications Richa Joshi, Hem C. Joshi Advanced Drug Delivery Systems in Management of Chronic Obstructive Pulmonary Disease, 2025 Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disorder characterized by progressive airflow limitation and inflammation. Despite advancements in therapeutic strategies, COPD remains a significant global health burden. Nanotheranostics, an innovative approach integrating diagnostic and therapeutic functionalities within nanoscale platforms, has emerged as a promising avenue in COPD management. This chapter delves into the current status and implications of nanotheranostics in COPD. The multifunctionality of nanomedicine enables simultaneous diagnosis, targeted drug delivery, and monitoring of therapeutic responses, thereby addressing the complex pathophysiology of COPD. Various nanocarriers, including liposomes, polymeric nanoparticles, and dendrimers, offer advantages such as prolonged drug retention, enhanced cellular uptake, and reduced systemic toxicity. Additionally, nanomaterial-based imaging agents facilitate precise disease detection and monitoring. Moreover, nanotheranostics enable personalized treatment strategies through the integration of biomarkers and imaging modalities for disease profiling and response prediction. Real-time monitoring of therapeutic efficacy allows for timely adjustments, optimizing patient outcomes and minimizing adverse effects. Furthermore, the potential of nanotechnology in modulating inflammatory pathways, promoting tissue repair, and overcoming drug resistance underscores its utility in COPD management. However, challenges such as biocompatibility, scalability, and regulatory concerns necessitate further research and development efforts for clinical translation. Collaborative endeavors between clinicians, scientists, and regulatory agencies are imperative to streamline the translation of nanotheranostics into clinical practice. Ethical considerations regarding safety, accessibility, and cost-effectiveness should also be addressed to ensure equitable healthcare delivery.
Development of a quartz crystal microbalance-based immunosensor for the early detection of mesothelin in cancer Hem C. Joshi, Himanshu Kharkwal, Ajay Kumar, Piyush Kumar Gupta Sensors International, 2023 A robust real-time flow injection assay using Quartz Crystal Microbalance (QCM) biosensor has been developed for the detection of mesothelin, an antigen expressed on various malignant tumors including mesothelioma and ovarian cancers. A QCM sensor chip functionalized with self-assembled monolayer of cysteamine used to fabricate a sensitive immunosensor. Mesothelin specific antibody was immobilized on cysteamine modified gold surface of quartz crystal using N-ethyl-N’-(3-dimethylaminopropyl) carbodiimide and N-hydroxy succinimide coupling. Further, ethanolamine was used as a blocking reagent to prevent the non-specific adsorption on antibody functionalized gold surface. Various concentrations of mesothelin was tested and the resonant frequency variation of the crystal was observed by a quartz crystal microbalance until a stable response is obtained. A good correlation between the frequency changes and concentration of mesothelin tested was observed and the QCM biosensor detects mesothelin in the linear range of 100pg/mLto 50 ng/mL. Thus, QCM assay could be a promising technique for early diagnosis of mesothelioma, ovarian and pancreatic adenocarcinoma.
Effects of varied nutrient regimes on soil health and long-term productivity in a rice–wheat system: insights from a 29-year study in the mollisols of the Himalayan Tarai region Manoj Kumar Bhatt, D. K. Singh, K. P. Raverkar, Ramesh Chandra, Navneet Pareek, Prithwiraj Dey, Biswajit Pramanick, Hem Chandra Joshi, Mukesh Kumar, Ahmed Gaber, Amnah Mohammed Alsuhaibani, Akbar Hossain Frontiers in Sustainable Food Systems, 2023 The maintenance of sustainability and quantification of soil health in the rice–wheat system in the Himalayan tarai region is of utmost importance, and a long-term study can properly demonstrate what needs to be done to achieve this. The current study was conducted after the completion of a 29-year crop cycle in the rice–wheat system in 2015 at Pantnagar. Since the beginning of the experiment in 1984, various NPK combinations with or without Zn and farmyard manure (FYM) applications were maintained in a fixed layout along with an absolute control plot without any external nutrition. FYM at 5 mg ha−1 and Zn at 5 kg ha−1 were applied in only rice, and NPK-chemical fertilizers were applied both in rice and wheat. The results revealed that the application of N at 120 kg ha−1 + P at 40 kg ha−1 + K at 40 kg ha−1 + FYM at 5 mg ha−1 + Zn at 5 kg ha−1 (NPK + FYM + Zn) resulted in the maximum attainment of long-term system productivity and the sustainable yield index (SYI), which were 22% higher than those with NPK application. NPK + FYM + Zn and NPK + FYM also improved the soil's overall physical, chemical, and biological parameters. Soil organic carbon, dehydrogenase activity, soil available P and K, phosphate solubilizing bacteria, and actinomycetes were found to be the most important soil quality parameters in Mollisols. From this study, it can be concluded that the application of the recommended NPK along with FYM and Zn can improve soil health and sustain the system productivity of the rice–wheat system in Mollisols of the Himalayan tarai region.
Recent advances in the application of biochar in microbial electrochemical cells Sanchita Bipin Patwardhan, Soumya Pandit, Piyush Kumar Gupta, Niraj Kumar Jha, Jyoti Rawat, Hem C. Joshi, Kanu Priya, Meenal Gupta, Dibyajit Lahiri, Moupriya Nag, Vijay Kumar Thakur, Kavindra Kumar Kesari Fuel, 2022 The International Biochar Initiative classifies biochar as “a solid material derived from the carbonization of biomass.” Biochar is a solid substance produced during the thermochemical degradation of biomass. This paper describes several examinations that have been conducted to investigate novel utilization of biomass since biochar is affordable, environmentally beneficial, and can be utilized for diverse purposes, such as soil stabilization, wastewater treatment, greenhouse gas management and power generation. Biochar has also been applied in fuel cells and supercapacitors, according to the latest reports. Biochar has the potential to be new and tenable material for microbial fuel cell electrodes. Biochar MFCs made through pyrolysis and gasification, exhibited significant performance as compared to activated carbon and graphite granule. This paper emphasizes the use of biochar as electrodes in MFCs to facilitate the simultaneous treatment of wastewater and electricity generation while also providing additional commercial advantages. Applications of biochar in microbial fuel cells as separator membrane and cathode catalysts are also mentioned. Brief information on the future prospects of the use of biochar in microbial fuel cells is further summarized.
Spectroscopy and Its Advancements for Environmental Sustainability Om Prakash, Abhishek Pathak, Ajay Kumar, Vijay Kumar Juyal, Hem C. Joshi, Saurabh Gangola, Kiran Patni, Geeta Bhandari, Deep Chandra Suyal, Viveka Nand Bioremediation of Environmental Pollutants Emerging Trends and Strategies, 2021
Challenges and Prospects in Bioremediation Strategies for Groundwater Cleanup HC Joshi Bioremediation for Environmental Sustainability Hard ISBN: 9781779645777 E … , 2026 2026
Role of Nanotechnology in Plant Growth and Development HC Joshi, R Joshi, P Pant, B Patni Phyto Nanotoxicology : Mechanisms and Analytical Methodologies of Plant … , 2026 2026
Challenges and Opportunities in Bio-Click Chemistry HC Joshi, R Joshi, A Sikdar Bio-Click Chemistry: Expanding Horizons Beyond the Click. 1, 300 , 2026 2026
Climate-Responsive Plant Biology HC Joshi, S Gangola, M Rafatullah, D Udayanga Springer, Singapore 1, XXI, 305 , 2026 2026
Microbial Contributions to Greenhouse Gas Emissions P Pant Upadhyay, H Karki, HC Joshi Microbial Resilience - Adapting to the Challenges of Climate Change 1 , 2026 2026
Microbial Ecology of Extreme Weather Events H Karki, P Pant Upadhyay, HC Joshi Microbial Resilience - Adapting to the Challenges of Climate Change 1 , 2026 2026
Climate Change and Plant Physiology HC Joshi, N Joshi, SK Guru, S Gangola, NS Bhandari Climate Responsive Plant Biology 1, 25-39 , 2026 2026 Citations: 1
Symbiotic Relationships: Microbes and Plants in a Changing Climate HC Joshi, P Pant, H Karki, B Patni, D Udayanga Microbial Resilience – Adapting to the Challenges of Climate Change 1 , 2026 2026
Microbial adaptation under pH fluctuation: Response and molecular strategies HC Joshi, P Pant, H Karki, HK Chauhan, S Joshi Microbial Stress Biology :Development in Microbiology 1, 61-74 , 2026 2026
Challenges and Opportunities in Microbial and Sustainable Agriculture: A Brief Summary HC Joshi, R Joshi, S Gangola Microbiome and Its Contribution in Sustainable Agriculture and Food … , 2026 2026
Green Nanotechnology for the Management of Lung Cancer S Joshi, HC Joshi, S Gangola Nanotechnology and Drug Delivery Innovations in Lung Cancer Treatment 1 (1), 20 , 2026 2026
Physiological Characterization under the Influence of Drought Stress and Salicylic Acid in Valeriana wallichii DC S Ansari, B Patni, D Jangpangi, HC Joshi, MK Bhatt, V Purohit biorxiv, 698547 , 2026 2026 Citations: 1
Electron Microscopy: Sample preparation, visualization and data interpretation HC Joshi, R Joshi, H Kharkwal, S Gangola Agricultural Microbiology -Basic and Advanced Laboratory Techniques 1 , 2026 2026
Applications of Biosensors in the Bioremediation of Pollutants HC Joshi, R Joshi, O Prakash, S Gangola Environmental Microbiomics: Multi-Omics Tools for Pollution Remediation and … , 2026 2026
Improvement in Orchard Nutrient Status and Productivity Through Integrated Nutrient Management in Mango (Mangifera indica L.) Under Medium-Density Planting Kuldeep, AK Singh, A Bhatnagar, O Singh, SP Pachauri, SC Shankhdhar, ... bioRxiv, 697138 , 2025 2025
Comparative Evaluation of Conventional Inorganic Fertilization and Sesbania rostrata Green Manuring on Soil Properties and the Growth and Development of Oryza sativa L. ‘Pant … HC Joshi, B Patni, SK Guru, MK Bhatt, M Singh bioRxiv, 696455 , 2025 2025
Revolutionizing Drug Discovery: Cutting-Edge Innovations in Mass Spectrometry HC Joshi, P Pant, HK Chauhan, A Verma Modern Spectroscopic Techniques for Drug Discovery and Environmental … , 2025 2025
Nanotheranostics for Chronic Obstructive Pulmonary Disease (COPD): Status and Implications R Joshi, HC Joshi Advanced Drug Delivery Systems in Management of Chronic Obstructive … , 2025 2025
Rehabilitation services in India: Addressing diverse needs HC Joshi ENVIS Newsletter 20 (4), 11-12 , 2024 2024
Influence of Establishment Techniques and Foliar Nutrient Spray Timing on Growth, Yield Parameters, Crop Productivity, Quality, and Economic Viability of Soybean (Glycine max L … A Rawat, DK Singh, S Chandra, HC Joshi, MK Bhatt ENVIS Bulletin Himalayan Ecology 31, 157-165 , 2024 2024
MOST CITED SCHOLAR PUBLICATIONS
Influence of Long-term Chemical fertilizers and Organic Manures on Soil Fertility - A Review MK Bhatt, R Labanya, HC Joshi Universal Journal of Agricultural Research 7 (5), 177-188 , 2019 2019 Citations: 322
Recent advances in the application of biochar in microbial electrochemical cells SB Patwardhan, S Pandit, PK Gupta, NK Jha, J Rawat, HC Joshi, K Priya, ... Fuel 311, 122501 , 2022 2022 Citations: 119
Long-term effects of inorganic fertilizers and FYM on soil chemical properties and yield of wheat under rice-wheat cropping system MK Bhatt, R Labanya, HC Joshi, N Pareek, R Chandra, KP Raverkar HIMALAYAN ECOLOGY 25, 28 , 2017 2017 Citations: 40
Detection of Rota Virus with the Help of Nanomaterial Based Field Effect Transistor (BIO-FET) M Pant, H Kharkwal, KP Singh, HC Joshi Biosensors journal 6 (2), 149 , 2017 2017 Citations: 20
Effect of long-term inorganic and organic manure on physical and biological properties of soil in Uttarakhand-A review MK Bhatt, R Labanya, HC Joshi, M Nand ENVIS Bulletin Himalayan Ecology 27, 49-54 , 2020 2020 Citations: 14
Soil Health and System Productivity in a 29-year Long-Term Rice-Wheat System are Influenced by Varied Nutrient Regimes in Mollisols of Himalayan tarai Region M Bhatt, B Pramanick, KP Raverkar, R Chandra, N Pareek, P Dey, ... Frontiers in Sustainable Food Systems 7, 1206878 , 2023 2023 Citations: 13
Consequences of integrated use of organic and inorganic fertilizers on yield and yield elements of rice HC Joshi, B Joshi, SK Guru, SC Shankdhar, A Kumar, BS Mahapatra, ... International Journal of Agricultural Science and Research 7 (5), 163-166 , 2017 2017 Citations: 11
Fabrication and Characterization of Layered Graphene Oxide Biocompatible Nano-Film by Various Methods H Kharkwal, HC Joshi, KP Singh International Journal of Biochemistry and Biophysics 6 (1), 1-19 , 2018 2018 Citations: 10
A Comparison between the Grain Quality Parameters of Rice Grown under Organic and Inorganic Production System HC Joshi, O Prakash, MK Nautiyal, BS Mahapatra, SK Guru Universal Journal of Plant Science 7 (2), 19-27 , 2019 2019 Citations: 9
Spectroscopy and Its Advancements for Environmental Sustainability O Prakash, A Pathak, A Kumar, VK Juyal, HC Joshi, S Gangola, K Patni, ... Bioremediation of Environmental Pollutants: Emerging Trends and Strategies … , 2021 2021 Citations: 8
Development of a quartz crystal microbalance-based immunosensor for the early detection of mesothelin in cancer HC Joshi, H Kharkwal, A Kumar, PK Gupta Sensors International 4, 100248 , 2023 2023 Citations: 6
Challenges and Opportunities in Scaling Up Plant Functional Trait-Based Approaches HC Joshi, P Pant, HK Chauhan Plant functional traits for improving productivity 1, 301-327 , 2024 2024 Citations: 5
Evaluation of Some Rice (Oryza sativa L.) Genotypes for Drought Tolerance K Maurya, HC Joshi, SC Shankhdhar, SK Guru, AK Guar, MK Nautiyal, ... International Journal of Current Microbiology and Applied Sciences 10 (2 … , 2021 2021 Citations: 5
Soil nutrient status of Bhabhar and hill areas of Uttarakhand N Pareek, KP Raverkar, MK Bhatt, S Kaushik, S Chandra, G Singh, ... ENVIS Bulletin Himalayan Ecology 27, 89-93 , 2020 2020 Citations: 5
Biological Activities of Metal Complexes with Rutin and Bio-Conjugate of Citrus Extract O Prakash, B Belal, J Dhanik, A Verma, HC Joshi, Vivekanand Universal Journal of Chemistry 7 (1), 1-24 , 2020 2020 Citations: 5
Application of nanopore of solid membrane for recognition of fluorescent Pseudomonas HC Joshi, KP Singh, A Tomar, P Singh International Journal of Biochemistry and Biophysics 5 (3), 53-64 , 2017 2017 Citations: 5
Comparative index for water pollution by rural and urban means A Gaur, O Prakash, HC Joshi The Pharma Innovation Journal 9 (5), 359-365 , 2020 2020 Citations: 4
Management of Isoproturon-Resistant Phalaris minor in Wheat by Alternate Herbicides under Tarai Region Conditions Prinsa, HC Joshi, B Joshi, SK Guru Journal of Agricultural Science and Food Research 10 (3), 263 , 2019 2019 Citations: 4
Antimicrobial activity of different Citrus species against different pathogenic bacteria O Prakash, J Dhanik, B Belal, A Verma, HC Joshi, Vivekanand international journal of chemical studies 6 (3), 3023-3029 , 2018 2018 Citations: 3
Effects of varied nutrient regimes on soil health and long-term productivity in a rice-wheat system: insights from a 29-year study in the mollisols of the Himalayan Tarai … MK Bhatt, DK Singh, KP Raverkar, R Chandra, N Pareek, P Dey, ... FRONTIERS IN SUSTAINABLE FOOD SYSTEMS 8 , 2024 2024 Citations: 2
