Biochemistry, Genetics and Molecular Biology, Biochemistry, Genetics and Molecular Biology
35
Scopus Publications
587
Scholar Citations
14
Scholar h-index
17
Scholar i10-index
Scopus Publications
Functional and Genomic insights into probiotic Lactic Acid Bacteria isolated from the Gastrointestinal microbiota of domestic rabbits (Oryctolagus cuniculus) Oluwatosin Olubunmi Oladipo, Abimbola Olumide Adekanmbi, Opeyemi U. Lawal, Valeria R. Parreira, Bolaji Fatai Oyeyemi, Olatunji Abubakar Jimoh, Aderemi Akinyemi, Charles Ayorinde Ologunde, Ayonposi Bukola Olaoye, Olugbenga David Oloruntola, Mitra Soni, Harmanpreet Kaur, Lawrence Goodridge BMC Microbiology, 2026 Probiotics play vital roles in maintaining gut health and overall well-being of animals, and have been isolated from the guts of several animals. The caecotrophic and dynamic nature of rabbit gut make them a promising site for probiotic prospecting. This study therefore, investigated the probiotic properties and whole genome sequence profile of Lactic Acid Bacteria (LAB) isolated from the gut microflora of domestic rabbit. Gastrointestinal contents of rabbits were cultured anaerobically on de Mann Rogosa Sharpe (MRS) agar using the pour-plate method. Isolates obtained were initially identified using 16S rRNA sequencing and later using Whole genome sequencing. Probiotic properties of the LAB were determined using conventional in vitro tests such as acid and phenol tolerance, adhesion ability, susceptibility to commonly-used antibiotics and the antimicrobial activity of their cell-free supernatants against selected test microorganisms. Whole genome analysis was carried out on selected isolates to further confirm their probiotic and safety properties. Three LAB showing probiotic properties were obtained and identified: Enterococcus lactis UIADO22, E. lactis UIADO37, and Enterococcus hirae UIADO30. All isolates were non-haemolytic, DNAse-negative, tolerant to pH 2, and maintaining viability in simulated duodenal juice. They were all sensitive to the tested antibiotics and their cell-free supernatants demonstrated antibacterial activity against selected test bacteria. Whole genome sequencing revealed the absence of vancomycin resistance and virulence genes (IS16, esp, hyl) in the LAB, confirming their safety. Probiotic potential was further supported by the detection of genes encoding bacteriocins such as Enterolysin_A, Subtilosin_A, Enterocin_L50a/L50b, Lanthionine synthetase, and Enterocin_P. Biosynthetic gene clusters for antimicrobial metabolites, including cyclic-lactone autoinducers, Type III polyketide synthase, terpene precursors, sactipeptides, RIPP-like peptides, and Lanthipeptide Class II, were also detected. Genes associated with stress resistance especially bile, acid and phenol (such as dltA, dltB, ssb and dltC), DNA/protein repair (such as recA, uvrA, uvrB,and recN), adhesion and anti-pathogenic activity (such agrB, agrD, fsrA,and fbp3) were detected in the genomes of the three LAB. Overall, the rabbit-derived Enterococcus spp. from this study exhibited both in vitro and genomic characteristics of safe, functional probiotics with strong antimicrobial potential. Enterococcus hirae UIADO30 is the most promising isolate because it lacks plasmids and virulence markers thereby reducing the risk of gene transfer—while carrying markers for bile and acid resistance.
Genotoxicity and Genomic Instability Induced by Micro- and Nanoplastics: A Comprehensive Multi-Taxa Mechanistic Review Abass Toba Anifowoshe, Bolaji Fatai Oyeyemi, Olufunke Adenike Opeyemi, Sandra Teniola Adebayo, Kehinde Mofesola Bankole, Testimony Adesewa Adegbite, Emmanuel Oluwafemi Olusola, Saratu Iyabode Abdulkareem, Abodh Kumar Jha, Upendra Nongthomba Journal of Applied Toxicology, 2026 Micro‐ and nanoplastics (MNPs) are pervasive contaminants increasingly implicated in DNA damage and genomic instability across biological systems. This systematic review addresses two core questions: (1) How do MNPs induce genotoxic effects and/or genomic instability in invertebrates, vertebrates, and human cell lines? (2) Through which molecular mechanisms and cellular pathways do these particles exert genotoxic effects? To answer these questions, the review employs an analytical framework integrating mechanistic toxicology, comparative organismal evidence, and pathway‐level synthesis. Using PRISMA‐guided methods, data were compiled from studies assessing oxidative stress, DNA strand breaks, chromosomal alterations, and disruption of repair pathways. Across aquatic and terrestrial organisms, as well as human epithelial and fly model models, MNP exposure consistently activated oxidative stress pathways, impaired base‐excision and nucleotide‐excision repair, triggered inflammatory signaling (e.g., NF‐κB), and induced apoptosis or cell‐cycle arrest. The framework highlights converging mechanisms—including ROS overproduction, mitochondrial dysfunction, and direct nuclear interactions—that collectively compromise genome integrity. These` findings reveal a coherent pattern of genotoxicity across taxa and underscore the growing public‐health and ecological risks associated with rising MNP pollution. The review identifies critical knowledge gaps, particularly in chronic low‐dose exposures, polymer diversity, and environmentally aged particles, and calls for standardized mechanistic research to inform regulatory interventions.
Draft genomes of three Enterococcus species recovered from the gastrointestinal microbiota of healthy domestic rabbits (Oryctolagus cuniculus) Abimbola Olumide Adekanmbi, Oluwatosin Olubunmi Oladipo, Opeyemi U. Lawal, Valeria R. Parreira, Bolaji Fatai Oyeyemi, Olatunji Abubakar Jimoh, Aderemi Akinyemi, Charles Ayorinde Ologunde, Ayoponsi Bukola Olaoye, Olugbenga David Oloruntola, Mitra Soni, Harmanpreet Kaur, Lawrence Goodridge Microbiology Resource Announcements, 2026 We report the draft genome sequences of three Enterococcus strains isolated from the gastrointestinal tract of domestic rabbits. These genomes contribute to expanding the representation of Enterococcus diversity in non-conventional hosts and provide resources for future comparative and functional genomics of gut-adapted Enterococci.
From Gene Discovery to Clinical Applications: The Journey of Genomic Research Bolaji Fatai Oyeyemi, Muhammad Abiodun Sulaiman, Saheedat Olabisi Dauda, Habeebat Adekilekun Oyewusi, Oluwatosin Olubunmi Oladipo, Habeebulahi Ajibola Adekilekun Genomics and Precision Healthcare Innovations Applications and Challenges, 2026 Fast-moving genomic research has cut across our understanding of biology, mechanisms underlying diseases, and personalized medicine. This chapter gives a bird's-eye view of the transformational journey of genomics—from fundamental discoveries in genes to impactful clinical applications. From the basic number of critical breakthroughs regarding gene discovery and sequencing technologies, we trace the growth in genomic tools, including high-throughput sequencing, CRISPR gene editing, and bioinformatic-driven data analysis. The chapter emphasizes critical landmarks, like the Human Genome Project, and the consequences those have had for identifying genetic causes of diseases. This also includes a discussion on integrating multi-omics approaches in deciphering complex biological networks and pathways. Strong emphasis has been placed on translating these genomic insights into clinical practice, developing novel diagnostics, targeted therapies, and personalized treatments in oncology, rare genetic disorders, and infectious diseases. This chapter summarizes current issues in genomic research, including ethical issues, data privacy, and equity in access to genomic medicine. Through case stories of clinical successes, it underlines the commitment of researchers, clinicians, and policy thinkers in collaboration to bridge the gap from gene discovery to patient care. This chapter provides a wide-ranging perspective on how medically relevant research based on the study of genomes will shape the future of medicine by reflecting backwards and speculating forwards on its transformational potential.
Exposure and Bioaccumulation of Mercury Impacted the Extent of Cellular Damage and Oxidative Stress in Local Chickens Around Ilesha Gold Mining Areas of Nigeria Bolaji F. Oyeyemi, Paul Ayodeji Awonegan, Adekunle Wahab Oyeyemi, Olatunji Abubakar Jimoh, John Babatope Owabumoye, Abiodun O. Fatoye, Olugbenga Samson Onile, Abass Toba Anifowoshe, Peter Olusakin Oladoye Environmental Toxicology, 2026 Mercury (Hg) is a well‐known global pollutant of environmental concern. Uncontrolled mining activities represent an avenue for its release and possible environmental contamination. Ilesha gold mining areas are characterized by extensive artisan and small‐scale gold mining (ASGM) activities. However, it is largely unknown to what extent Hg pollution has occurred as well as the environmental and ecological deterioration in the area. Here, we studied Hg in soil, sediments, water, chicken blood, liver, muscle (chest), and kidney. Oxidative stress, hepatorenal damage, heat shock response, cellular DNA damage, and mRNA levels of apoptosis‐related genes were analyzed using qPCR. All analyses were done in chickens from gold mining (GMA) and non‐gold mining areas (NGMA). This study reported that the levels of Hg in soil (range: 1.637 ± 0.237–1.796 ± 0.104 μg/g), sediment (range: 1.424 ± 0.046–1.450 ± 0.062 μg/g), and water (range: 1.255 ± 0.071–1.378 ± 0.145 μg/mL) in GMA far exceeded Hg levels in NGMA. This might imply the extent to which ASGM activities have contributed to the Hg contamination in the areas. Chickens from GMA exhibited significantly high Hg levels, with the largest proportion bioaccumulated in the kidney (range: 0.596 ± 0.057–0.605 ± 0.028 μg/g) and lowest proportion in blood (range: 0.215 ± 0.023–0.226 ± 0.043 μg/g), suggesting the health risks dwellers in the area are prone to. Cellular damage biomarkers were significantly elevated in the tissue of Hg‐exposed chickens from GMA compared to those from NGMA, demonstrating the significant health risks associated with Hg pollution and/or uptake in the areas.
Hepato-renal toxicity of mercury bioaccumulation in cage-free chickens (Gallus gallus domesticus) from gold-producing areas of Zamfara State, Nigeria Zainab Abdulmalik, Muftau Shittu, Sani Adamu, Suleiman Folorunsho Ambali, Bolaji F. Oyeyemi Environmental Sciences Europe, 2025 Artisanal gold mining in Zamfara State involves using toxic mercury to separate gold from the ore. Information on the potential impact of mercury on the liver and kidney in cage-free chickens (Gallus domesticus) in areas where gold is extracted in Anka LG is scarce. Compared to non-gold miners, this study determined serum mercury, liver and kidney toxic biomarkers and tissue architecture changes in cage-free chickens from Anka goldfield areas (AGA). Sixty adult apparently healthy chickens were randomly selected from AGA and non-gold mining areas (NGMA) (30 from each location). Hg level was determined using atomic absorption spectrophotometer with thermal decomposition. Liver and kidney toxic biomarkers and architecture were analysed using biochemical and standard methods. Multivariate, correlation, regression and ANOVA were used to test differences. The mean serum mercury level (0.228 μg/L) in cage-free animals of the goldfield was substantially (p < 0.05) high in contrast to the undetectable mercury level in chickens from non-gold mining areas (NGMA). The mean alkaline phosphatase (41.577 U/L) of chickens in AGA was significantly higher than (28.448 U/L) that of the non-goldfield. Significantly higher alanine transaminase, aspartate aminotransferase, creatinine, bilirubin and gamma-glutamyl transferase were also observed in chickens from AGA. All significance were at p < 0.05. Liver and kidney architecture of chickens from goldfield shows varying degrees of distortion, including infiltration of inflammatory cells, hepatocyte cytoplasmic vacuolation, sinusoid dilation, renal tubular necrosis, and glomerular shrinkage. Thus, artisanal gold mining causing mercury biomagnification in cage-free chickens may be harmful, as seen by altered liver and kidney toxic biomarkers and tissue architecture.
Cellular stress and Inflammatory Responses in Mice Exposed to Aspergillus nigerus, Rhizopus oryzae, and Rhizopus delemar Latin American Journal of Pharmacy, 2023
Sexual dimorphism in ratio of second and fourth digits and its relationship with metabolic syndrome indices and cardiovascular risk factors Journal of Research in Medical Sciences, 2014
Functional and Genomic insights into probiotic Lactic Acid Bacteria isolated from the Gastrointestinal microbiota of domestic rabbits (Oryctolagus cuniculus) OO Oladipo, AO Adekanmbi, OU Lawal, VR Parreira, BF Oyeyemi, ... BMC microbiology 26, 478 , 2026 2026
Medicinal plants with antineoplastic potency and possible biomarkers for monitoring and diagnosing neoplastic disease HA Adekilekun, OD Omodamiro, NK Achi, BA Tijani, HA Oyewusi, ... Oncology and Translational Medicine 12 (2), 76-94 , 2026 2026
Antioxidants from Algae: Treasured Natural Compounds for Human Benefits HA Oyewusi, HA Adekilekun, AB Tijani, OO Oladipo, BF Oyeyemi Algae and Algal Metabolites: Emerging Applications, Trends and Prospects, 1-25 , 2026 2026
Exposure and Bioaccumulation of Mercury Impacted the Extent of Cellular Damage and Oxidative Stress in Local Chickens Around Ilesha Gold Mining Areas of Nigeria BF Oyeyemi, PA Awonegan, AW Oyeyemi, OA Jimoh, JB Owabumoye, ... Environmental Toxicology , 2026 2026
Techniques for Isolating and Culturing Algae OO Oladipo, HA Adekilekun, HA Oyewusi, BF Oyeyemi, AB Tijani Algae and Algal Metabolites: Emerging Applications, Trends and Prospects, 1-30 , 2026 2026
Draft genomes of three Enterococcus species recovered from the gastrointestinal microbiota of healthy domestic rabbits ( Oryctolagus cuniculus ) AO Adekanmbi, OO Oladipo, OU Lawal, VR Parreira, BF Oyeyemi, ... Microbiology Resource Announcements, e01162-25 , 2026 2026
Genotoxicity and Genomic Instability Induced by Micro‐and Nanoplastics: A Comprehensive Multi‐Taxa Mechanistic Review AT Anifowoshe, BF Oyeyemi, OA Opeyemi, ST Adebayo, KM Bankole, ... Journal of Applied Toxicology , 2026 2026
EVALUATION OF BIOACTIVE COMPOUNDS, IN-VITRO ANTIOXIDANT PROFILE AND ANTI-INFLAMMATORY PROPERTIES OF ETHANOLIC EXTRACTS OF ISOBERLINIA TOMENTOSA AH Adekilekun, OD Omodamiro, NK Achi, HA Oyewusi, RM Omodamiro, ... FUDMA JOURNAL OF SCIENCES 9 (12), 148-158 , 2025 2025 Citations: 1
NMR based human gut metabolomic profiling reveals altered metabolites associated with pulmonary and extra-pulmonary tuberculosis V Sharma, A Singh, S Sharma, M Gaur, AK Malaisamy, D Rawat, A Yadav, ... Metabolomics 22 (1), 1 , 2025 2025
Bacterial community structure and secondary metabolite insights from halophiles at Oniru Beach, Lagos AC Olaleye, HA Oyewusi, KA Akinyede, OO Oladipo, BF Oyeyemi Archives of Microbiology 207 (11), 299 , 2025 2025 Citations: 1
Reproductive Potential of Selenium on Aluminium Sulphate-Treated Prepubertal Male Wistar Rats AW Oyeyemi, WM Owonikoko, AO Akinola, BF Oyeyemi, OO Daramola, ... Nigerian Journal of Biochemistry and Molecular Biology 40 (1), 96-106 , 2025 2025
Hepato-renal toxicity of mercury bioaccumulation in cage-free chickens ( Gallus gallus domesticus ) from gold-producing areas of Zamfara State, Nigeria Z Abdulmalik, M Shittu, S Adamu, SF Ambali, BF Oyeyemi Environmental Sciences Europe 37 (1), 179 , 2025 2025 Citations: 2
Biochemical analyses of bio-wastes-based 45S5 bioglass-ceramics in male Wistar rats SS Owoeye, DO Folorunso, FO Aramide, BF Oyeyemi, SG Borisade, ... Sustainable Chemistry One World, 100140 , 2025 2025
Differentially regulated saliva proteome and metabolome: a way forward for risk-assessment of oral cancer among tobacco abusers BF Oyeyemi, S Dabral, A Paramaraj, S Srinivasan, GD Jhingan, D Kumar, ... Molecular Omics, https://doi.org/10.1039/D5MO00058K , 2025 2025 Citations: 1
Effect of Nigella sativa oil and organophosphate antidote, Pralidoxime-Chloride on blood pressure variables and cardiac apoptotic-related gene expression in dichlorvos-exposed … ST Shittu, FO Jibril, SA Shittu, A Imam, TA Jarikre, BF Oyeyemi, ... Journal of Applied Sciences & Environmental Management 29 (9) , 2025 2025 Citations: 1
Bacterial Diversity and Characterisation of Secondary Metabolite from Halophilic Bacterial Isolated from Popular Metropolitan Marine Oniru Beach, Lagos, Nigeria AC Olaleye, HA Oyewusi, KA Akinyede, OO Oladipo, BF Oyeyemi 2025
Emerging roles of noncoding RNA for biosynthesis of secondary metabolites in ethnomedicinal plants HA Oyewusi, OO Olubunmi, BA Tijani, BF Oyeyemi, HA Adekilekun Ethnomedicinal Plants for Drug Discovery: Current Developments, 369-383 , 2024 2024 Citations: 3
Preparation and characterization of ZnO modified solid state sintered 45S5 bioactive ceramics SS Owoeye, SM Abegunde, BF Oyeyemi, EO Isinkaye Hybrid Advances 6, 100251 , 2024 2024 Citations: 2
Urine Metabolomics Reveals Overlapping Metabolic Associations Between Preeclampsia and Gestational Diabetes NR Agarwal, G Kachhawa, BF Oyeyemi, NS Bhavesh Indian Journal of Clinical Biochemistry 39 (3), 356-364 , 2024 2024 Citations: 6
Esteroides y fertilidad de conejos alimentados con harina de hojas de Phyllanthus amarus como aditivo alimentario OA Jimoh, HO Okin-Aminu, BF Oyeyemi, UD Osayande, CU Nwachukwu, ... Archivos de zootecnia 73 (282), 72-76 , 2024 2024
MOST CITED SCHOLAR PUBLICATIONS
Gene frequencies of ABO and Rh blood groups in Nigeria: A review AT Anifowoshe, OA Owolodun, KM Akinseye, OA Iyiola, BF Oyeyemi Egyptian Journal of Medical human genetics 18 (3), 205-210 , 2017 2017 Citations: 101
Sexual dimorphism in ratio of second and fourth digits and its relationship with metabolic syndrome indices and cardiovascular risk factors BF Oyeyemi, OA Iyiola, AW Oyeyemi, KA Oricha, AT Anifowoshe, ... Journal of research in medical sciences: the official journal of Isfahan … , 2014 2014 Citations: 68
FTO gene associates and interacts with obesity risk, physical activity, energy intake, and time spent sitting: pilot study in a Nigerian population BF Oyeyemi, CA Ologunde, AB Olaoye, NA Alamukii Journal of obesity 2017 (1), 3245270 , 2017 2017 Citations: 44
Reproductive characteristics, semen quality, seminal oxidative status, steroid hormones, sperm production efficiency of rabbits fed herbal supplements AJ Olatunji, AO Wahab, OOA Hafsat, BF Oyeyemi. Theriogenology 168, 41-49 , 2021 2021 Citations: 34
Stringent response protein as a potential target to intervene persistent bacterial infection GS Kushwaha, BF Oyeyemi, NS Bhavesh Biochimie, DOI:10.1016/j.biochi.2019.07.006 , 2019 2019 Citations: 34
Development of multiepitope subunit protein vaccines against Toxoplasma gondii using an immunoinformatics approach OS Onile, GJ Ojo, BF Oyeyemi, GO Agbowuro, AI Fadahunsi NAR Genomics and Bioinformatics 2 (3), lqaa048 , 2020 2020 Citations: 28
Unravelling the anti-inflammatory mechanism of Allium cepa: an integration of network pharmacology and molecular docking approaches V Omoboyede, OS Onile, BF Oyeyemi, RT Aruleba, AI Fadahunsi, GA Oke, ... Molecular Diversity, 10.1007/s11030-023-10614-w , 2023 2023 Citations: 22
Plasma metabolomic study in perinatally HIV infected children using 1H NMR spectroscopy reveals perturbed metabolites that sustain during therapy T Kaur, S.U., Oyeyemi, B.F.,* Shet, A., Gopalan, B.P., Himanshu, D., Bhavesh ... Plos ONE 15 (8), e0238316 , 2020 2020 Citations: 22
Perfluorooctanoic acid dominates the molecular-level effects of a mixture of equal masses of perfluorooctanoic acid and perfluorooctane sulfonic acid in earthworm Z Han, BF Oyeyemi, JE Zenobio, OA Salawu, AS Adeleye Journal of Hazardous Materials 457, 131718 , 2023 2023 Citations: 21
Microbiome analysis of saliva from oral squamous cell carcinoma (OSCC) patients and tobacco abusers with potential biomarkers for oral cancer screening BF Oyeyemi, US Kaur, A Paramaraj, Chintamani, R Tandon, A Kumar, ... Heliyon, https://doi.org/10.1016/j.heliyon.2023.e , 2023 2023 Citations: 20
Histological changes, micronuclei induction and nuclear abnormalities in the peripheral erythrocytes of Clarias gariepinus (Burchell 1822) exposed to water sample from Apodu … A Anifowoshe, J Oyebanji, O Oladipo, F Oyeyemi, M Abdulrahim, ... Journal of Life and Bio Sciences Research 1 (01), 01-07 , 2020 2020 Citations: 19
Soursop juice enhanced seminal antioxidant defence and semen quality of rabbit bucks in extremely dry climatic condition of Southwestern Nigeria OA Jimoh, BF Oyeyemi, WA Oyeyemi Journal of thermal biology 100, 103034 , 2021 2021 Citations: 18
An immunoinformatics approach for the design of a multi-epitope subunit vaccine for urogenital schistosomiasis CA Olugbenga Samson Onile, Adeyinka I. Fadahunsi, Ameerah A. Adekunle ... PeerJ 8, e8795 , 2020 2020 Citations: 17
Frequency of twinning in Kwara State, North-Central Nigeria FOM Boalji F Oyeyemi, O.A Iyiola, U A Raheem Egyptian Journal of Medical Human Genetics Volume 14, Issue 1, January 2013 … , 2013 2013 Citations: 17
Physiochemical analyses and molecular characterization of heavy metal-resistant bacteria from Ilesha gold mining sites in Nigeria GJ Ojo, OS Onile, AO Momoh, BF Oyeyemi, V Omoboyede, AI Fadahunsi, ... Journal of Genetic Engineering and Biotechnology 21 (1), 172 , 2023 2023 Citations: 14
Potential of watermelon (Citrullus lanatus) to maintain oxidative stability of Rooster semen for Artificial Insemination A Jimoh, M Akinola, B Oyeyemi, W Oyeyemi, S Ayodele, I Omoniyi, ... Journal of Animal Science and Technology , 2020 2020 Citations: 11
Relationship between ratio of second and fourth digit and obesity traits among different ethnic groups in Ilorin, North Central Nigeria BF OYEYEMI, JO ADEBAYO, AT ANIFOWOSHE, OA IYIOLA Notulae Scientia Biologicae 8 (4), 396-400 , 2016 2016 Citations: 10
Assessment of blood mercury, immune response, heat shock and oxidative stress marker in free-ranging chicken (Gallus Gallus domesticus) from gold mining areas in Zamfara State … Z Abdulmalik, M Shittu, S Adamu, SF Ambali, BF Oyeyemi Journal of Hazardous Materials Advances 8, 100176 , 2022 2022 Citations: 9
Effects of Ascorbic Acid on Reproductive Functions of Male Wistar Rats Exposed to Nicotine TK Bolaji F oyeyemi, Wahab A oyeyemi, Sheu Shittu, R. Ajah Journal of African Association of Physiological Sciences 2 (2): 110-116 … , 2014 2014 Citations: 9
Metabolic profiling of serum and urine in preeclampsia and gestational diabetes in early pregnancy NR Agarwal, G Kachhawa, BF Oyeyemi, NS Bhavesh Medicine in Drug Discovery 16, 100143 , 2022 2022 Citations: 7